CN103028060A - Traditional Chinese medicine composition for treating infant acute eczema and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating infant acute eczema and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides an externally applied traditional Chinese medicine composite for treating infant acute eczema. The externally applied traditional Chinese medicine composite comprises oriental wormwood, rhizoma anemarrhenae, rhizoma phragmitis, lithospermum erythrorhizon, burdock, gallnut, rhizoma bletillae, polygonum aviculare, phaseolus calcaratus, fructus chaenomelis, dandelion, radix peucedani, hempleaf negundo chastetree leaves, radix scutellariae, radix sophorae flavescentis, hairy euphorbia, dendrobium, Chinese holly, codonopsis pilosula, lithospermum erythrorhizon, swertia pseudochinensis, sevenlobed yam rhizome, radix saposhnikoviae and radix gentianae. The traditional Chinese medicine composite has the advantages that the traditional Chinese medicine composite is good in transdermal absorptivity and curative effect, takes effect rapidly, does not result in adverse effects or tolerance, and has no toxic or side effects, the illness is not recurrent easily compared with externally applied western medicine.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of the infant acute eczema and preparation method thereof.
Background technology
More anxious during the infant eczema outbreak, usual earlier erythema occurs in the affected part, occurs subsequently and syringe needle general big or small pimple and vesicle, has part pimple and vesicle can mutually be fused into bulla; Bleb can form rotten to the corn face after breaking, and treatment then will generate pustule or pus than easy infection if fail in time.If do not have to have treated thoroughly the minority sufferer can by acute be transformed into chronic; And the pruritus symptom often occurs very easily cause fungal infection.
Baby's acute eczema is mainly in 0～2 years old period of infant, generally after birth one, morbidity in February and two, March, the baby was also multiple, the high dermis that caused by multiple internal and external factor and the inflammation of epidermis, it is generally acknowledged relevant with allergy, its erythra has pleomorphism, symmetrical, be easy to ooze out repeatedly outbreak, conscious pruritus, easily develop into chronic, do not stay the feature of cicatrix after having more, sickness rate has the trend that increases in recent years, because the keratodermatitis of infant is thinner, capillary network is abundant and endothelium is moisture and chloride is many, responsive to various stimulating factors, be more prone to occur eczema, ill rear affected part pruritus is unbearably, often irritated, the uneasiness of crying and screaming brings many troubles for infant and the head of a family.
The oral Loratadine of the at present many employings of western medical treatment eczema, but taking baby ' is inconvenient, easily choke when taking medicine and cause into trachea and to suffocate and threat to life, and such medicine uses too much, excessively of a specified duration, cerebral nervous system is had infringement, easily recurrence after the drug withdrawal, be difficult for radical cure, therefore, be difficult for adopting oral mode to treat the acute eczema of infant.The mode that doctor trained in Western medicine also adopts external to smear is treated eczema, and the most frequently used external used medicine roughly is divided into two classes: the corticosteroid cream: such as hydrocortisone, dexamethasone; Non-corticosteroid ointment, paste: thunderous zinc paste etc., this two classes medicine is prolonged and repeated to be applied to neonate, infant all in various degree defective, the prolonged and repeated use of corticosteroid, can make the part cause the untoward reaction such as temporary adrenal cortex inhibition, and the Transdermal absorption of paste is relatively poor, curative effect is unsatisfactory.
The traditional Chinese medical science thinks, the acute stage of infant eczema is commonly considered as " skin ulcer ", and chronic phase is thought " tinea ", baby's acute eczema is called the categories such as " eczema ", " acute eczema " in motherland's medical science, the generation of primary disease is often not anti-because of the infant natural endowment, improper feeding, interior living noxious dampness; Wind, wet, thermal resistance are put to death heresy and are fought mutually in skin, and due to the contamination skin, baby's acute eczema etiology and pathogenesis be that baby's function is not yet physically well developed, the taste transfer function a little less than, or lose the day after tomorrow fosterly, eating and drinking without temperance causes dysfunction of the spleen in transportation, damp and hot interior life.
The present invention is exactly on the basis of theory of Chinese medical science, a kind of external medicine composition that is used for the treatment of the infant acute eczema has been proposed, the medicine of smearing with respect to the doctor trained in Western medicine external, it is good that this Chinese medicine composition has percutaneous absorbability, good effect, instant effect has no adverse reaction, the state of an illness is difficult for occuring repeatedly, has no drug resistance and toxic and side effects.
Summary of the invention
Technical problem to be solved by this invention is, a kind of external medicine composition that is used for the treatment of the infant acute eczema is provided, the medicine of smearing with respect to the doctor trained in Western medicine external, it is good that this Chinese medicine composition has percutaneous absorbability, good effect, instant effect has no adverse reaction, the state of an illness is difficult for occuring repeatedly, has no drug resistance and toxic and side effects.
In order to solve the problems of the technologies described above, the invention provides a kind of external medicine composition that is used for the treatment of the infant acute eczema, the crude drug of described external medicine composition comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae.
Wherein, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 30 weight portions ~ 40 weight portions in the described external medicine composition, the Rhizoma Anemarrhenae 70 weight portions ~ 80 weight portions, Rhizoma Phragmitis 60 weight portions ~ 70 weight portions, Radix Arnebiae (Radix Lithospermi) 25 weight portions ~ 35 weight portions, Fructus Arctii 20 weight portions ~ 30 weight portions, Galla Chinensis 40 weight portions ~ 50 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portion Herba Polygoni Avicularis, 25 weight portions ~ 35 weight portions, Semen Phaseoli 35 weight portions ~ 45 weight portions, Fructus Chaenomelis 15 weight portions ~ 25 weight portions, Herba Taraxaci 50 weight portions ~ 60 weight portions, Radix Peucedani 10 weight portions ~ 20 weight portions, Folium Viticis Negundo 25 weight portions ~ 35 weight portions, Radix Scutellariae 85 weight portions ~ 95 weight portions, Radix Sophorae Flavescentis 40 weight portions ~ 50 weight portions, Ramulus et Folium Bauhiniae Faberi 45 weight portions ~ 55 weight portions, Herba Dendrobii 40 weight portions ~ 50 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 30 weight portions ~ 40 weight portions, Radix Codonopsis 45 weight portions ~ 55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portions ~ 40 weight portions, when medicine 20 weight portions ~ 30 weight portion Rhizoma Dioscoreae Septemlobaes, 25 weight portions ~ 35 weight portions, Radix Saposhnikoviae 15 weight portions ~ 25 weight portions, Radix Gentianae 30 weight portions ~ 40 weight portions.
Wherein, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 33 weight portions ~ 37 weight portions in the described external medicine composition, the Rhizoma Anemarrhenae 73 weight portions ~ 77 weight portions, Rhizoma Phragmitis 63 weight portions ~ 67 weight portions, Radix Arnebiae (Radix Lithospermi) 28 weight portions ~ 32 weight portions, Fructus Arctii 23 weight portions ~ 27 weight portions, Galla Chinensis 43 weight portions ~ 47 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 33 weight portions ~ 37 weight portion Herba Polygoni Avicularis, 28 weight portions ~ 32 weight portions, Semen Phaseoli 38 weight portions ~ 42 weight portions, Fructus Chaenomelis 18 weight portions ~ 22 weight portions, Herba Taraxaci 53 weight portions ~ 57 weight portions, Radix Peucedani 13 weight portions ~ 17 weight portions, Folium Viticis Negundo 28 weight portions ~ 32 weight portions, Radix Scutellariae 88 weight portions ~ 92 weight portions, Radix Sophorae Flavescentis 43 weight portions ~ 47 weight portions, Ramulus et Folium Bauhiniae Faberi 48 weight portions ~ 52 weight portions, Herba Dendrobii 43 weight portions ~ 47 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 33 weight portions ~ 37 weight portions, Radix Codonopsis 48 weight portions ~ 52 weight portions, the Rhizoma Atractylodis Macrocephalae 33 weight portions ~ 37 weight portions, when medicine 23 weight portions ~ 27 weight portion Rhizoma Dioscoreae Septemlobaes, 28 weight portions ~ 32 weight portions, Radix Saposhnikoviae 18 weight portions ~ 22 weight portions, Radix Gentianae 33 weight portions ~ 37 weight portions.
Wherein, the dosage form of described external medicine composition is washing liquid, powder, unguentum, oil preparation, tincture, cream, gel.
The present invention also provides the preparation method of above-mentioned external medicine composition, and when the dosage form of described external medicine composition was washing liquid, it was specially:
Each crude drug component of described external medicine composition is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.3g/ml ~ 0.6g/ml, obtains washing liquid.
The present invention also provides the using method of washing liquid of the preparation method preparation of above-mentioned external medicine composition, is specially:
Select the sterile gauze pad that is of moderate size according to the skin lesion area, stick in the affected part, with syringe the Chinese medicine drop is spilt on it again, gauze pad humidity is advisable not drip, how much determine the frequency that gauze pad is changed depending on secretions, if the affected part only has a small amount of secretions, should drip at any time and spill medicinal liquid to keep the humidity of gauze pad, each 20min ~ 30min.
The present invention also provides the preparation method of above-mentioned external medicine composition, and when the dosage form of described external medicine composition was powder, it was specially:
The first step, each crude drug component of described external medicine composition is mixed in proportion, adding is soaked first 20min ~ 40min with respect to the distilled water of 6 ~ 8 times of mixture qualities, pours in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, and obtains filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor of acquisition is filtered again, obtains filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), and regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, obtain the first filtrate;
Second step, with beta-schardinger dextrin-use with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality fully after, slowly add the volatile oil of first step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 1:5, and constantly stirs 1h ~ 2h, behind the cold preservation 24h, filter, spray drying is pulverized, obtain volatile oil embedding thing
The 3rd step, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, and obtains 100 orders ~ 200 purpose powder.
The present invention also provides the using method of powder of the preparation method preparation of above-mentioned external medicine composition, is specially:
Described powder is added vaseline with respect to 1 ~ 2 times of its quality, transfer and all be applied to aseptic dried sliver, put in the container, after the high pressure steam sterilization sterilization, stick in the affected part, each 20min ~ 30min.
The present invention also provides a kind of external medicine composition washing liquid that is used for the treatment of the infant acute eczema, the crude drug of described washing liquid comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae
The preparation method of described washing liquid is specially,
Each crude drug component of described external medicine composition is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.3g/ml ~ 0.6g/ml, obtains washing liquid.
The present invention also provides a kind of external medicine composition powder that is used for the treatment of the infant acute eczema, the crude drug of described powder comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae
The preparation method of described powder is specially,
The first step, each crude drug component of described external medicine composition is mixed in proportion, adding is soaked first 20min ~ 40min with respect to the distilled water of 6 ~ 8 times of mixture qualities, pours in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, and obtains filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor of acquisition is filtered again, obtains filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), and regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, obtain the first filtrate;
Second step, with beta-schardinger dextrin-use with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality fully after, slowly add the volatile oil of first step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 1:5, and constantly stirs 1h ~ 2h, behind the cold preservation 24h, filter, spray drying is pulverized, obtain volatile oil embedding thing
The 3rd step, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, and obtains 100 orders ~ 200 purpose powder.
Beneficial effect of the present invention:
The external medicine composition that is used for the treatment of the infant acute eczema provided by the invention, with respect to the medicine that the doctor trained in Western medicine external is smeared, it is good that this Chinese medicine composition has percutaneous absorbability, good effect, instant effect has no adverse reaction, the state of an illness is difficult for occuring repeatedly, has no drug resistance and toxic and side effects.
The specific embodiment
The acute stage of infant eczema, be commonly considered as " skin ulcer ", chronic phase, thought " tinea ", baby's acute eczema is called the categories such as " eczema ", " acute eczema " in motherland's medical science, baby's acute eczema is for due to the heresy that is subjected to rheumatism outward, " Standards of Diagnosis and Treatment " cloud: " toxic fetal sore; or report fetal heat in pregnancy, or the poison of female diet of being pregnent, the fire of seven emotions." " General Treatise on the Cause and Symptoms of Diseases " cloud: " the skin ulcer disease is invaded between skin by ailment said due to cold or exposure, becomes urticaria, and gives youngster and drink breast, and milk steeps dirty youngster's face and gives birth to." as seen from upper, baby's acute eczema cause of disease comes from the natural endowment deficiency, belongs to susceptibility body constitution; Eating and drinking without temperance will lose it and will take good care of the day after tomorrow; The amblent air temperature impact, the place, residence touches thing; It is irritable easily to swash, and feelings will is hindered.Exopathogenic factor wind, wet, pathogenic heat take advantage of a favourable situation to harass, and wind raises up, the benefaction number becomes and see that heresy fights in skin, are the pleomorphism infringement, and pruritus is immoderate.The damp and hot injection flesh natural fibre line of meat sees that then the erythra redness is scorching hot, and insufficiency of the spleen leading to overabundance of dampness is seen stream Tianjin contamination; Or see delay repeatedly, and with the passing of time then injure cloudy blood, blood-deficiency and wind-dry occurs and form chronic.Because of damp deep glutinous greasy, strongly fragrant and heat-transformation, damp and hot knot, touching difficulty more, permanent current yellow fluid then.Because of wind being YANG-pathogen, easily attack the sun position again, therefore eczema is often sent out in women's head-ornaments; Wind benefaction and number becomes, therefore the eczema regular incidence is rapid, pruritus unbearably.
The traditional Chinese medical science thinks that primary disease belongs to innate deficiency more, and spleen fortune is lost strong, retention of damp-heat in the interior, or experience the wind heat damp, inside and outside two heresies are fought mutually, strongly fragrantly fall ill in the flesh natural fibre line of meat, and children's's body belongs to the young sun of young the moon, and internal organs are tender and lovely, shape gas does not fill, and loses congenital defect or the day after tomorrow and supports, and all can cause dysfunction of the spleen in transportation, endogenous damp formation, and the skin skin is fragile, and hedge is not solid, and exogenous wind is easily invasion and attack again, with the endogenous dampness knot of fighting, accumulate in the flesh table, send out and be eczema, mostly be acute eczema, wind heat is wet all contains, especially with the pathogenic heat damp for very.
In sum, this sick cause of disease is damp and hot interior life always, and he is evil for diseases caused by exogenous pathogenic factor, therefore treatment is take clearing away heat-damp and promoting diuresis, invigorating the spleen and regulating the stomach, dispelling wind for relieving itching, healing up sore and subduing swelling as principle.
The external medicine composition that the present invention proposes on the basis of this principle, it comprises following crude drug component:
Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae.
Preferably, described external medicine composition only is made of above-mentioned raw materials medicine component.
In the side, Herba Artemisiae Scopariae energy supernatant liver and gall excess-fire, under let out dampness-heat in the liver and gallbladder, the pathogenic fire purging dehumidifying, pathogenesis hits, the Rhizoma Anemarrhenae, the Rhizoma Phragmitis clearing away heat-fire, outstanding kind clearing stomach is through excess-heat, the Radix Arnebiae (Radix Lithospermi) clearing away heat and cooling blood, promoting blood circulation and detoxication, Fructus Arctii dispelling wind and heat pathogens, detoxifcation rash, the gallic acid adstringency is cold, the pathogenic fire reducing of astringing the lung, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, arresting sweating hemostasis, it is wet that extra earning is held back in external, the Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation ， Herba Polygoni Avicularis, the Semen Phaseoli clearing away heat-damp and promoting diuresis, inducing diuresis to remove edema, killing parasites for relieving itching, the Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral, the stomach function regulating removing dampness, the Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the Radix Peucedani wind heat clearing away of faling apart, the Folium Viticis Negundo expelling pathogenic wind from the body surface, removing damp to relieve itching, Radix Scutellariae, the Radix Gentianae heat clearing and damp drying, eliminating fire and detoxication, the Radix Sophorae Flavescentis heat clearing and damp drying, the parasite killing diuresis, the Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing, dampness removing is antipruritic, the Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, the Ilex purpurea Hassk.[I.chinensis Sims heat-clearing and toxic substances removing, the detumescence blood stasis dispelling, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid, when the medicine clearing away damp-heat, stomach invigorating, the Rhizoma Dioscoreae Septemlobae dampness removing dispels the wind, the Radix Saposhnikoviae expelling wind and dampness, Radix Saposhnikoviae is dispeled the wind and delivers, removing dampness to relieve pain, the Radix Gentianae heat-clearing and toxic substances removing, all medicines share, and play altogether clearing away heat-damp and promoting diuresis, invigorating the spleen and regulating the stomach, dispelling wind for relieving itching, the effect of healing up sore and subduing swelling.
The external medicine composition provided by the invention disease institute that not only can go directly, through thoroughly reaching the mechanism performance local therapeutic effects such as space between skin and muscles, happy passages through which vital energy circulates, QI and blood regulating, can also pass through flesh natural fibre line of meat hair key, go deep into the effect that internal organs play Chinese medicine, have sterilization, anti-inflammatory anti-itch, astriction.
The weight portion of each crude drug is respectively in the described external medicine composition:
Herba Artemisiae Scopariae 30 weight portions ~ 40 weight portions, the Rhizoma Anemarrhenae 70 weight portions ~ 80 weight portions, Rhizoma Phragmitis 60 weight portions ~ 70 weight portions, Radix Arnebiae (Radix Lithospermi) 25 weight portions ~ 35 weight portions, Fructus Arctii 20 weight portions ~ 30 weight portions, Galla Chinensis 40 weight portions ~ 50 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portion Herba Polygoni Avicularis, 25 weight portions ~ 35 weight portions, Semen Phaseoli 35 weight portions ~ 45 weight portions, Fructus Chaenomelis 15 weight portions ~ 25 weight portions, Herba Taraxaci 50 weight portions ~ 60 weight portions, Radix Peucedani 10 weight portions ~ 20 weight portions, Folium Viticis Negundo 25 weight portions ~ 35 weight portions, Radix Scutellariae 85 weight portions ~ 95 weight portions, Radix Sophorae Flavescentis 40 weight portions ~ 50 weight portions, Ramulus et Folium Bauhiniae Faberi 45 weight portions ~ 55 weight portions, Herba Dendrobii 40 weight portions ~ 50 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 30 weight portions ~ 40 weight portions, Radix Codonopsis 45 weight portions ~ 55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portions ~ 40 weight portions, when medicine 20 weight portions ~ 30 weight portion Rhizoma Dioscoreae Septemlobaes, 25 weight portions ~ 35 weight portions, Radix Saposhnikoviae 15 weight portions ~ 25 weight portions, Radix Gentianae 30 weight portions ~ 40 weight portions.
The weight portion of each crude drug further preferably is respectively in the described external medicine composition:
Herba Artemisiae Scopariae 33 weight portions ~ 37 weight portions, the Rhizoma Anemarrhenae 73 weight portions ~ 77 weight portions, Rhizoma Phragmitis 63 weight portions ~ 67 weight portions, Radix Arnebiae (Radix Lithospermi) 28 weight portions ~ 32 weight portions, Fructus Arctii 23 weight portions ~ 27 weight portions, Galla Chinensis 43 weight portions ~ 47 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 33 weight portions ~ 37 weight portion Herba Polygoni Avicularis, 28 weight portions ~ 32 weight portions, Semen Phaseoli 38 weight portions ~ 42 weight portions, Fructus Chaenomelis 18 weight portions ~ 22 weight portions, Herba Taraxaci 53 weight portions ~ 57 weight portions, Radix Peucedani 13 weight portions ~ 17 weight portions, Folium Viticis Negundo 28 weight portions ~ 32 weight portions, Radix Scutellariae 88 weight portions ~ 92 weight portions, Radix Sophorae Flavescentis 43 weight portions ~ 47 weight portions, Ramulus et Folium Bauhiniae Faberi 48 weight portions ~ 52 weight portions, Herba Dendrobii 43 weight portions ~ 47 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 33 weight portions ~ 37 weight portions, Radix Codonopsis 48 weight portions ~ 52 weight portions, the Rhizoma Atractylodis Macrocephalae 33 weight portions ~ 37 weight portions, when medicine 23 weight portions ~ 27 weight portion Rhizoma Dioscoreae Septemlobaes, 28 weight portions ~ 32 weight portions, Radix Saposhnikoviae 18 weight portions ~ 22 weight portions, Radix Gentianae 33 weight portions ~ 37 weight portions.
The weight portion of each crude drug most preferably is respectively in the described external medicine composition:
Herba Artemisiae Scopariae 35 weight portions, the Rhizoma Anemarrhenae 75 weight portions, Rhizoma Phragmitis 65 weight portions, Radix Arnebiae (Radix Lithospermi) 30 weight portions, Fructus Arctii 25 weight portions, Galla Chinensis 45 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 35 weight portion Herba Polygoni Avicularis 30 weight portions, Semen Phaseoli 40 weight portions, Fructus Chaenomelis 20 weight portions, Herba Taraxaci 55 weight portions, Radix Peucedani 15 weight portions, Folium Viticis Negundo 30 weight portions, Radix Scutellariae 90 weight portions, Radix Sophorae Flavescentis 45 weight portions, Ramulus et Folium Bauhiniae Faberi 50 weight portions, Herba Dendrobii 45 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 35 weight portions, Radix Codonopsis 50 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, when medicine 25 weight portion Rhizoma Dioscoreae Septemlobaes 30 weight portions, Radix Saposhnikoviae 20 weight portions, Radix Gentianae 35 weight portions.
Each crude drug pharmacology is as follows:
Herba Artemisiae Scopariae: latin name Artemisiae Scopariae Herba, bitter in the mouth, suffering, cold nature, enter spleen, stomach, liver, gallbladder meridian, have clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer, be used for jaundice, no matter damp and hot YANG jaundice or cold-damp YIN jaundice all can be used, and also can be applicable to due to fever disease in summer or the hygropyrexia cards such as oliguria with reddish urine.
The Rhizoma Anemarrhenae: latin name Anemarrhenae Rhizoma, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.
Rhizoma Phragmitis: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, has the lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting, cure mainly the dysphoria with smothery sensation that epidemic febrile disease joins the army minute thirsty, dryness of the tongue Tianjin is few, and the rash of measles goes out not saturating, and pathogenic heat is violated the cough and expectoration of lung, the cough vomiting pus of lung abscess, the damp and hot cards such as vomiting singultus that block in stomach.
Radix Arnebiae (Radix Lithospermi): latin name Arnebiae Radix, cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel have removing heat from blood and promoting blood circulation, the effect of detoxifcation rash, cure mainly that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, the cards such as constipation with heat retention, Radix Arnebiae (Radix Lithospermi) can be strengthened the effect of Cortex Phellodendri, makes the vasoconstriction of inflamed sites, inflammation is alleviated, and make the skin of destruction form fine and close protein, the effect of antiinflammatory and convergence is arranged.
Fructus Arctii: acrid in the mouth, hardship; Cold in nature, return lung, the stomach warp has dispelling wind and heat pathogens, the heat-clearing and toxic substances removing rash, the effect that the lung qi dispersing sore-throat relieving is loose swollen, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out freely not reach the rubella pruritus; The card such as sore swollen toxin and mumps.
Galla Chinensis: latin name Galla Chinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, have the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; The chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, Galla Chinensis energy enhancing body can strengthen the immunologic function of cell to the defence capability of nonspecific stimulation, and this pathogenic bacterium are had inhibitory action, and can the antiviral growth.
Pseudobulbus Bletillae (Rhizoma Bletillae): latin name Bletillac Rhizoma, bitter in the mouth, sweet, puckery, cold nature is returned lung, liver, stomach warp; have the tonifying the lung hemostasis, detumescence and promoting granulation, the effect of sore cures mainly lung and hinders hemoptysis; epistaxis, incised wound is hemorrhage, swollen ulcer drug; ulcer pain, the soup fire is burnt, the cards such as rhagadia manus et pedis; Pseudobulbus Bletillae (Rhizoma Bletillae) includes Rhizoma Bletillae gel, can make leukocyte recruitment, forms artificial thrombosis; reach the effect of rapid hemostasis, the phlegmatic temperament that Pseudobulbus Bletillae (Rhizoma Bletillae) contains can cover form thin film at wound surface and reach hemorrhage of protection and stop blooding.
Herba Polygoni Avicularis: latin name Polygoni Avicularis Herba, bitter in the mouth, cold nature enters urinary bladder channel, has relieving stranguria by diuresis, the effect of killing parasites for relieving itching is used for stranguria, especially sand Stranguria, stranguria caused by urinary stone, dysuria, jaundice due to damp-heat, dysentery is with inferior card, and Herba Polygoni Avicularis has significant diuresis
Semen Phaseoli: latin name Vignae Semen, sweet in the mouth, acid, property is flat, has diuretic kinds that disappear, and the effect of removing toxic substances and promoting pus discharge is for cards such as edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Fructus Chaenomelis: property is put down, is slightly cold, and sweet in the mouth is returned liver, spleen channel, has the suppressing the hyperactive liver Shujin, and the effect of stomach function regulating removing dampness cures mainly the arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, the convulsion of vomiting and diarrhoea, the cards such as beriberi edema.
Herba Taraxaci: latin name Taraxaci Herba, sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, have the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to the acute mastitis effect, also can be used for the cards such as conjunctival congestion and swelling pain of flaming up of liver-fire.
Radix Peucedani: latin name Peucedani Radix, bitter in the mouth, suffering, cold nature enters lung meridian, and dispelling wind-heat is arranged, and the effect of lowering the adverse-rising QI and dispelling phlegm is mainly used in wind-heat cough, and the card such as cough with asthma, chest and diaphragm due to the expectorant heat choke, lung qi poetry anthology be unfavorable.
Folium Viticis Negundo: latin name Viticis NegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has the removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Detoxifcation, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, the effect of pain relieving cures mainly Common Cold, cough, asthma; Stomachache; Stomachache; The heat-damp in summer dysentery; Beriberi swelling; The rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature enters the heart, lung, stomach, gallbladder, large intestine channel, and heat clearing and damp drying is arranged, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Radix Sophorae Flavescentis: latin name Sophorae Flavescentis Radix, bitter in the mouth, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, have the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
Ramulus et Folium Bauhiniae Faberi: latin name Euphorbiae Hirate Herba, mildly bitter flavor, little acid, cool in nature, have heat-clearing and toxic substances removing, the effect that dampness removing is antipruritic is used for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.
Herba Dendrobii: latin name Dendrobii Caulis, cold nature, sweet in the mouth is returned stomach, kidney channel, has reinforcing stomach reg fluid, and the effect of nourishing YIN and clearing away heat cures mainly cloudy impairment of body fluid and loses, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.
Ilex purpurea Hassk.[I.chinensis Sims: latin name Ilicis Chinensis Folium, bitter in the mouth, cold in nature, return lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, the effect of promoting blood circulation and hemostasis is used for chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external, ulcer of the lower limb, and leprelcosis, extra earning is hemorrhage, cold injury, mastitis, the cards such as chapped skin.
Radix Codonopsis: sweet in the mouth, property is flat, returns lung, spleen channel, has the QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, cure mainly deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, transfer regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes intestinal to the absorption of nutrient substance.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, the QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Work as medicine: latin name Swertiae Hebra, bitter in the mouth, cold in nature, return liver, stomach, large intestine channel, have clearing away damp-heat, the effect of stomach invigorating cures mainly jaundice due to damp-heat, hypochondriac pain, dysentery stomachache, the cards such as inappetence.
Rhizoma Dioscoreae Septemlobae: latin name DioscoreaeSpongiosaeRhizoma, property is flat, and bitter in the mouth is returned kidney, stomach warp, has dampness removing and goes turbidly, and the effect of the blood stasis dispelling that dispels the wind is used for the cards such as gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature enters lung, liver, spleen, urinary bladder channel, and expelling cold and relieving exterior syndrome is arranged, and removing dampness to relieve pain is expellingged wind and relieving convulsion, and antipruritic effect is mainly used in affection of exogenous wind-cold card and cold-evil's closing, the syndrome of superficies cold and interior heat of interior-heat pent-up etc.
Radix Gentianae: latin name Gentianae Radix etRhizoma, bitter in the mouth, cold in nature, return liver, gallbladder meridian, have the effect of heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire, cure mainly jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, liver-fire conjunctival congestion, Hiccough and deaf, hypochondriac pain bitter taste, persistent erection of the penis, the cards such as convulsion with spasms.
The dosage form of described external medicine composition can be washing liquid, powder, unguentum, oil preparation, tincture, cream, gel, and the acute eczema sepage is more, usually adopt washing liquid and powder, local vascular is shunk, and hyperemia alleviates, sepage reduce and reach antiinflammatory, antipruritic, suppress the purpose of oozing out.
When the dosage form of described external medicine composition was washing liquid, its preparation method was specially:
Described each crude drug component is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.3g/ml ~ 0.6g/ml, obtains washing liquid.
The present invention also provides the using method of above-mentioned external medicine composition washing liquid, is specially:
Select the sterile gauze pad that is of moderate size according to the skin lesion area, stick in the affected part, with syringe the Chinese medicine drop is spilt on it again, gauze pad humidity is advisable not drip, how much determine the frequency that gauze pad is changed depending on secretions, if the affected part only has a small amount of secretions, should drip at any time and spill medicinal liquid to keep the humidity of gauze pad, each 20min ~ 30min.
When the dosage form of described external medicine composition was powder, its preparation method was specially:
The first step, described each crude drug component is mixed in proportion, adding is soaked first 20min ~ 40min with respect to the distilled water of 6 ~ 8 times of mixture qualities, pours in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, and obtains filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor of acquisition is filtered again, obtains filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), and regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, obtain the first filtrate;
Second step, with beta-schardinger dextrin-use with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality fully after, slowly add the volatile oil of first step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 1:5, and constantly stirs 1h ~ 2h, behind the cold preservation 24h, filter, spray drying is pulverized, obtain volatile oil embedding thing
The 3rd step, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, and obtains 100 orders ~ 200 purpose powder.
The present invention also provides the using method of above-mentioned external medicine composition powder, is specially:
Described powder is added vaseline with respect to 1 ~ 2 times of its quality, transfer and all be applied to aseptic dried sliver, put in the container, after the high pressure steam sterilization sterilization, stick in the affected part, each 20min ~ 30min.
The present invention also provide above-mentioned external medicine composition for the preparation of the treatment acute eczema medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The concrete preparation of embodiment 1 washing liquid 1
With Herba Artemisiae Scopariae 35g, Rhizoma Anemarrhenae 75g, Rhizoma Phragmitis 65g, Radix Arnebiae (Radix Lithospermi) 30g, Fructus Arctii 25g, Galla Chinensis 45g, Pseudobulbus Bletillae (Rhizoma Bletillae) 35g Herba Polygoni Avicularis 30g, Semen Phaseoli 40g, Fructus Chaenomelis 20g, Herba Taraxaci 55g, Radix Peucedani 15g, Folium Viticis Negundo 30g, Radix Scutellariae 90g, Radix Sophorae Flavescentis 45g, Ramulus et Folium Bauhiniae Faberi 50g, Herba Dendrobii 45g, Ilex purpurea Hassk.[I.chinensis Sims 35g, Radix Codonopsis 50g, Rhizoma Atractylodis Macrocephalae 35g, as medicine 25g Rhizoma Dioscoreae Septemlobae 30g, Radix Saposhnikoviae 20g, Radix Gentianae 35g mixes, the distilled water that adds 6.7kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, the distilled water that in filtering residue, again adds 3kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leave standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.5g/ml, obtains washing liquid 1.
The concrete preparation of embodiment 2 washing liquids 2
With Herba Artemisiae Scopariae 33g, Rhizoma Anemarrhenae 73g, Rhizoma Phragmitis 63g, Radix Arnebiae (Radix Lithospermi) 28g, Fructus Arctii 23g, Galla Chinensis 43g, Pseudobulbus Bletillae (Rhizoma Bletillae) 33g Herba Polygoni Avicularis 28g, Semen Phaseoli 38g, Fructus Chaenomelis 18g, Herba Taraxaci 53g, Radix Peucedani 13g, Folium Viticis Negundo 28g, Radix Scutellariae 88g, Radix Sophorae Flavescentis 43g, Ramulus et Folium Bauhiniae Faberi 48g, Herba Dendrobii 43g, Ilex purpurea Hassk.[I.chinensis Sims 33g, Radix Codonopsis 48g, Rhizoma Atractylodis Macrocephalae 33g, as medicine 23g Rhizoma Dioscoreae Septemlobae 28g, Radix Saposhnikoviae 18g, Radix Gentianae 33g mixes, the distilled water that adds 6.5kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, the distilled water that in filtering residue, again adds 3kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leave standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.5g/ml, obtains washing liquid 2.
The concrete preparation of embodiment 3 washing liquids 3
With Herba Artemisiae Scopariae 37g, Rhizoma Anemarrhenae 77g, Rhizoma Phragmitis 67g, Radix Arnebiae (Radix Lithospermi) 32g, Fructus Arctii 27g, Galla Chinensis 47g, Pseudobulbus Bletillae (Rhizoma Bletillae) 37g Herba Polygoni Avicularis 32g, Semen Phaseoli 42g, Fructus Chaenomelis 22g, Herba Taraxaci 57g, Radix Peucedani 17g, Folium Viticis Negundo 32g, Radix Scutellariae 92g, Radix Sophorae Flavescentis 47g, Ramulus et Folium Bauhiniae Faberi 52g, Herba Dendrobii 47g, Ilex purpurea Hassk.[I.chinensis Sims 37g, Radix Codonopsis 52g, Rhizoma Atractylodis Macrocephalae 37g, as medicine 27g Rhizoma Dioscoreae Septemlobae 32g, Radix Saposhnikoviae 22g, Radix Gentianae 37g mixes, the distilled water that adds 7kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water of 3kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.5g/ml, obtains washing liquid 3.
The concrete preparation of embodiment 4 powders 1
With Herba Artemisiae Scopariae 35g, Rhizoma Anemarrhenae 75g, Rhizoma Phragmitis 65g, Radix Arnebiae (Radix Lithospermi) 30g, Fructus Arctii 25g, Galla Chinensis 45g, Pseudobulbus Bletillae (Rhizoma Bletillae) 35g Herba Polygoni Avicularis 30g, Semen Phaseoli 40g, Fructus Chaenomelis 20g, Herba Taraxaci 55g, Radix Peucedani 15g, Folium Viticis Negundo 30g, Radix Scutellariae 90g, Radix Sophorae Flavescentis 45g, Ramulus et Folium Bauhiniae Faberi 50g, Herba Dendrobii 45g, Ilex purpurea Hassk.[I.chinensis Sims 35g, Radix Codonopsis 50g, Rhizoma Atractylodis Macrocephalae 35g, as medicine 25g Rhizoma Dioscoreae Septemlobae 30g, Radix Saposhnikoviae 20g, Radix Gentianae 35g mixes, the distilled water that adds 6.7kg, soak first 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 6h, obtain volatile oil, remaining water extraction liquid filters, obtain filtrate, the distilled water that in filtering residue, again adds 3kg, decoct 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 80% ethanol to alcohol volume content, to account for total liquor capacity be 50% (V/V), regulating pH value is 7.0, leave standstill precipitate with ethanol, filter, obtain the first filtrate, with the beta-schardinger dextrin-of 4 times of volatile oil quality with the distilled water heating for dissolving fully after, slowly add described volatile oil, and constantly stir 2h, behind the cold preservation 24h, filter, spray drying, pulverize, obtain volatile oil embedding thing, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, obtain 150 purpose powder powder 1.
Embodiment 5 acute toxicity testings
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein 1 group of Cavia porcellus is the blank group, (smearing method of washing liquid is other four groups of washing liquids 1 of smearing respectively 0.70ml/kg embodiment 1 to embodiment 3 preparation: select the sterile gauze pad that is of moderate size according to the skin lesion area to washing liquid 3, stick in the affected part, with syringe the Chinese medicine drop is spilt on it again, each 30min), smear 0.70g/kg embodiment 4 preparation powder 1 (smearing method of powder is: with powder add with its etc. the vaseline of quality, transfer and all be applied to aseptic dried sliver, put in the container, after the high pressure steam sterilization sterilization, stick in the affected part each 30min), 24h before administration, with spinal column both sides, back unhairing (losing hair or feathers with 10% sodium sulfide after the first cropping), scope is slightly larger than 6 * 6cm.24h checks whether skin of unhairing is injured, and injured skin should not be made the toxicity test of intact skin after the unhairing, and the making of damaged skin adopts coarse sandpaper with the unhairing skin abrasion of sterilizing; take Seepage blood as degree, then smear washing liquid and powder at the unhairing place, observe the general reaction situation behind the 24h, continuously 7d.The body weight of record animal, skin and hair, the variation of eye and mucosa, the observation of poisoning manifestations is identical with the acute toxicity testing of whole body administration.To the animal of death is arranged, in time dissect, there is macroscopic pathological changes to carry out histopathologic examination, the result shows, the animal mental status, activity, breathing, diet, feces and body weight gain are all normal in the 7d, without performances such as secretions increases, without animal dead, observation period finishes to put to death the spoil perusal, and administration group group and matched group Cavia porcellus are showed no the internal organs ANOMALOUS VARIATIONS.
Embodiment 6 long term toxicity tests
50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g ~ 300g, be divided into 5 groups, every group 10, wherein smear intact skin for two groups, smear respectively washing liquid 1 and powder 1 (smearing method as described in Example 5), the applying amount of washing liquid is 0.70ml/kg, the applying amount of powder is 0.70g/kg, smear damaged skin for two groups, smear respectively washing liquid 1 and powder 1, the applying amount of washing liquid is 0.70ml/kg, the applying amount of powder is 0.70g/kg, remaining one group is matched group, and Cavia porcellus is spinal column both sides, 24h back unhairing before administration, and area is slightly larger than 6cm * 6cm.The making of damaged skin adopts coarse sandpaper scratch ， take Seepage blood as degree, and then by the group administration, be administered once every day, contacts skin 6h at every turn, successive administration 30d.Observe every day such as administration local skin and animal behavior activity, the mental status, food-intake, feces character etc.Weighed once in per 3 days, and adjust dosage by body weight.24h after the last administration puts to death 6 animals for every group and carries out hematology, blood biochemical and the inspection of pathology indices.Remaining animal is all put to death after making drug withdrawal recovery observation 15d, detects indices.Result's demonstration, abnormal change does not appear in above every observation index, or animal dead.Perusal: splanchnocoel is without oozing of blood, the organ administration group such as the heart, liver, kidney and matched group relatively, the aspects such as its color and luster, size, form are all without significant difference.Histological observation: it is normal that the heart, liver, nephridial tissue structure are respectively organized in administration, do not find obvious pathological change with matched group.
Embodiment 7 Experiments of Zoology
Animal
280 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into immediately 14 groups, every group 20, wherein 7 groups of impacts that are used for observing xylol induced mice auricle edema are respectively blank group, model control group, positive controls, treatment group 1 to treatment group 4,7 groups of impacts that are used for observing the mice delayed hypersensitivity are respectively blank group, model control group, positive controls, treatment group 5 to treatment group 8.
Reagent
Dimethylbenzene: Qingdao and nation's chemical industry company limited provide; Dinitrochlorobenzene (DNCB): Qingdao and nation's chemical industry company limited provide; Acetone: Qingdao and nation's chemical industry company limited provide; During experiment acetone is mixed with 1% and 5% DNFB (DNCB) acetone soln; Histamine phosphate: Shanghai gold fringe bio tech ltd provides; CGRP test kit: Beijing Fu Rui bio-engineering corporation.
Medicine
Treatment group 1 mice is smeared the washing liquid 1 of the embodiment of the invention 1 preparation, treatment group 2 mices are smeared the washing liquid 2 of the embodiment of the invention 2 preparations, treatment group 3 mices are smeared the washing liquid 3 of the embodiment of the invention 3 preparations, applying amount is 0.05ml/, treatment group 4 is smeared the powder 1 of the embodiment of the invention 4 preparations, applying amount is 0.05g/, the smearing method of powder and washing liquid as described in Example 5, the positive controls fluocinonide ointment, applying amount is 0.05g/, and model control group and blank group give isometric normal saline.
Statistical method
Measurement data adopts X ± s to represent, relatively adopts chi-square criterion, all data all to adopt the SPSS12.0 statistical software to process between group.
Method and result
The impact of xylol induced mice auricle edema
During experiment, each treatment group and positive controls are all smeared administration in auris dextra section, every day 1 time, continuous 7 days, the washing liquid applying amount was 0.05ml/, and the powder applying amount is 0.05g/, 30min after the last administration, with distilled water flush away medicine, clean with dry cotton ball, except the blank group, all the other each groups are all dripped dimethylbenzene 50 μ l in two sides, mouse right ear front and back and are caused inflammation, put to death mice behind the 1h, punch in mice left and right sides ears same area with card punch (8mm), and the weight of minute another name both sides auricle, take the difference of two auricle weight as swelling, calculate and respectively organize swelling, carry out statistical procedures, the results are shown in Table 1.
The impact of the acute ear swelling of table 1 medicine xylol induced mice
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 5.93+0.49 |
| Positive controls | 20 | 3.92+0.71 |
| Treatment group 1 | 20 | 1.46+0.63 |
| Treatment group 2 | 20 | 1.81 +0.54 |
| Treatment group 3 | 20 | 1.96 +0.80 |
| Treatment group 4 | 20 | 1.57 +0.62 |
| The blank group | 20 | 0.36 +0.11 |
As can be seen from Table 1, adopt the mice ear due to the Chinese medicine composition xylol of the present invention that remarkable inhibitory action is arranged.
The impact of the mice delayed hypersensitivity that DNFB (DNCB) is induced
Test the 1st day to model control group, positive controls, the treatment group 5 mouse web portion unhairing to treatment group 8, scope is 2cm * 2cm approximately, and evenly smears the abdominal part sensitized mice with 5%DNCB solution 0.1ml.Strengthened 1 time in the 2nd day.After the sensitization 7 days, excite again the modeling success with 1%DNCB acetone soln 0.1ml.
After exciting each group medicinal liquid is coated with each mouse right ear, put to death mice behind the 24h, blank group and DNCB model group normal saline gavage, every day gavage, treatment group 5 mouse right ears are smeared the washing liquid 1 of the embodiment of the invention 1 preparation, treatment group 6 mouse right ears are smeared the washing liquid 2 of the embodiment of the invention 2 preparations, treatment group 7 mouse right ears are smeared the washing liquid 3 of the embodiment of the invention 3 preparations, applying amount is 0.5ml/, and treatment group 8 mouse right ears are smeared the powder 1 of the embodiment of the invention 4 preparations, and applying amount is 0.5g/, positive controls is taken fluocinonide ointment, applying amount is 0.05g/, every day 2 times, continuous 7 days.Put to death mice and take off left and right sides auricle with card punch (diameter 8mm), the scales/electronic balance weighing amount, take the difference of two ear weight as swelling, (1) swelling is respectively organized in calculating, (2) plasma C GRP concentration: get blood 1ml through eyeball, inject the test tube of 10%EDTA and aprotinin, mixing, 40 ℃, 3000r/min, 10min separated plasma are with the concentration of putting the method for exempting from and measure CGRP.Carry out statistical procedures, the results are shown in Table 2 and table 3.
The anti-Delayed onset allergy of table 2 medicine (type Ⅳ allergy) effect
| Group | n | Ear swelling degree (mg) |
| Model control group | 20 | 6.97 +1.05 |
| Positive controls | 20 | 5.23 +0.93 |
| Treatment group 5 | 20 | 1.51 +0.60 |
| Treatment group 6 | 20 | 2.07 +0.41 |
| Treatment group 7 | 20 | 1.89 +0.37 |
| Treatment group 8 | 20 | 1.72 +0.62 |
| The blank group | 20 | 0.32 +0.09 |
Table 3 is on the impact of plasma C GRP
| Group | n | CGRP(pg/mL) |
| Model control group | 20 | 14.53 +1.86 |
| Positive controls | 20 | 23.81 +1.39 |
| Treatment group 5 | 20 | 31.29 +1.26 |
| Treatment group 6 | 20 | 27.61 +2.09 |
| Treatment group 7 | 20 | 28.39 +1.78 |
| Treatment group 8 | 20 | 30.69 +1.05 |
| The blank group | 20 | 35.27 +1.72 |
Can find out from table 2 and table 3, adopt Chinese medicine composition of the present invention can significantly suppress mice Delayed onset allergy.
Medicine is on the impact of Cavia porcellus local skin pruritus
60 of healthy guinea pigs, (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight are 250g ~ 300g, are divided at random 6 groups by body weight, 10 every group.If model control group, positive controls, treatment group 9 is to treatment group 12, model control group gives isometric normal saline, every day 1 time, continuous 7 days, after shaving hair to each group Cavia porcellus right back instep, adopt washing liquid and the powder of the present invention's preparation to smear shaving the hair place, treatment group 9 is smeared the washing liquid 1 of embodiment 1 preparation, treatment group 10 is smeared the washing liquid 2 of embodiment 2 preparations, treatment group 11 is smeared the washing liquid 3 of embodiment 3 preparations, and treatment group 12 is smeared the powder 1 of embodiment 4 preparations, and the smearing method of washing liquid and powder illustrates in embodiment 5, positive controls is smeared fluocinonide ointment, washing liquid 1 is 0.05ml/ to the applying amount of washing liquid 3, and the applying amount of powder 1 and fluocinonide ointment is 0.05g/, 1h after last administration in the 7th day, with coarse sandpaper abrade right back instep shave the hair sentence slight oozing of blood degree of being, area is 1m approximately
20.01% histamine phosphate's solution is dripped in beginning behind the 10min at the wound surface place, 0.05ml/ only, after this comply with 0.02%, 0.03%, 0.04% every 3min ... progressive concentration only is 0.05ml/ at every turn, later adds the metapedes instep until Cavia porcellus occurs, take histamine phosphate's total amount (μ g) of occurring at last being given when Cavia porcellus later licks the metapedes instep as itch-threshold, record and itch-threshold of relatively respectively organizing carry out statistical disposition, the results are shown in Table 4.
Table 4 medicine is on the impact of Cavia porcellus local skin pruritus
| Group | n | The threshold value of itching (μ g) |
| Model control group | 10 | 34.21 +1.96 |
| Positive controls | 10 | 73.66 +2.28 |
| Treatment group 9 | 10 | 126.38 +2.91 |
| Treatment group 10 | 10 | 108.12 +3.29 |
| Treatment group 11 | 10 | 112.40 +3.67 |
| Treatment group 12 | 10 | 119.65 +2.39 |
As can be seen from Table 4, adopt Chinese medicine composition of the present invention to have good itching-relieving action.
Embodiment 8 model cases
Liu, man, 4 months, medical on July 12nd, 2011, main suit: two buccal speckles, pimple 5 days, increase the weight of to accompany sepage, pruritus 2 days checks, physically well develop, slightly fat, the pimple of the visible intensive grain of rice size in two buccals, papulovesicle, erythema, the part erythra merges in flakes, and the yellow transudate of rotten to the corn companion is arranged, be diagnosed as the infant acute eczema, give immediately washing liquid 1 treatment of the embodiment of the invention 1 preparation, select the sterile gauze pad that is of moderate size according to the skin lesion area, stick in the affected part, with syringe 1 of washing liquid is spilt on it again, gauze pad humidity is advisable not drip, and how much determines the frequency that gauze pad is changed depending on secretions, if the affected part only has a small amount of secretions, drip at any time and spill medicinal liquid to keep the humidity of gauze pad, each 30min, every day 2 times, 7 days courses for the treatment of, fully recover after using 1 course for the treatment of, follow up a case by regular visits to half a year without recurrence.
Embodiment 9 model cases
The infant poplar, the man, 5 months, in first visit on November 12 in 2010.Infant is fat, body weight 10.5kg.It is rubescent that forehead, the tip of the brow, buccal appear in unknown cause before the first quarter moon, that continues pimple occurs, and yellow watery secretion is arranged, wipe away not to the utmost, skin lesion is towards periphery diffusion gradually, be diagnosed as acute eczema, give PIYANPING, urea frost is wiped before outward, the infant of at every turn applying medicinal lotion or ointment is cry and screamed, medication 10 days, the state of an illness is used washing liquid 1 treatment of the embodiment of the invention 1 preparation instead, 3 times on the 1st subsequently without improvement; Outer wiping 20% is the ginseng frost more, select the sterile gauze pad that is of moderate size according to the skin lesion area, stick in the affected part, with syringe 1 of washing liquid is spilt on it, gauze pad humidity is advisable not drip again, and how much determines the frequency that gauze pad is changed depending on secretions, if the affected part only has a small amount of secretions, drip at any time and spill medicinal liquid to keep the humidity of gauze pad, each 30min, every day 2 times, medication 2 days, skin lesion obviously disappears, and infant is quiet has a rest, and medication 7 days continues, skin lesion disappears fully, have rosy cheeks, recovery from illness is followed up a case by regular visits to 1 year without recurrence.
Embodiment 10 clinical datas
Select in March, 2010～2012 to make a definite diagnosis the acute phase eczema infant that oozes out of baby year February, symptom, the equal all cases of sign meet " skin cypridology ", and (People's Health Publisher publishes, 2002) and " traditional Chinese medical science disease Standardization of diagnosis and curative effect " issued of State Administration of Traditional Chinese Medicine (publishing in 1994) in the acute eczema diagnostic criteria, totally 192 examples, age 7d～22 month.Be divided at random treatment group and matched group, treatment group 109 examples, wherein, and male 62 examples, women 47 examples, matched group 83 examples, wherein, and male 51 examples, women 32 examples, two groups of cases are at the aspect difference not statistically significants such as sex, age, the course of disease, skin lesion position (P〉0.05).
Therapeutic Method
Treatment group adopts washing liquid 1 treatment of embodiment 1 preparation, selects the sterile gauze pad that is of moderate size according to the skin lesion area, sticks in the affected part, with syringe 1 of washing liquid is spilt on it again, and each 30min 2 times/d, 7 days 1 courses for the treatment of, treats 1 course for the treatment of;
Matched group is put Pevisone paste outward on the skin, and 3 times/d, 7 days 1 courses for the treatment of, totally 1 course for the treatment of.
Curative effect is judged
Recovery from illness: behind the treatment 7d, ooze and absorb fully night, erythema, pimple disappear fully, and subjective symptoms disappears.Produce effects: sepage absorbs fully, and erythema, pimple obviously disappear 〉=and 70%, subjective symptoms is clearly better.Effectively: the sepage basic absorption, 30%≤erythema, pimple＜80%, subjective symptoms alleviates.Invalid: still have a little sepage, erythema, pimple disappear＜and 30%, even increase the weight of.
The result
Two groups of Clinical efficacy comparisons see Table 5.
Table 5 liang group Clinical efficacy comparison
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 109 | 72 | 26 | 7 | 4 | 96.3 |
| Matched group | 83 | 34 | 29 | 8 | 12 | 85.5 |
As can be seen from Table 5, treatment group and matched group curative effect relatively have significant difference.
Cured person is followed up a case by regular visits to 6 months recurrences relatively, sees Table 6.
Table 6 cured person is followed up a case by regular visits to 6 months recurrences relatively
| Group | The recovery from illness number | The recurrence number | Relapse rate (%) |
| Treatment group | 72 | 2 | 2.78 |
| Matched group | 34 | 6 | 17.65 |
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (10)
1. external medicine composition that is used for the treatment of the infant acute eczema is characterized in that: the crude drug of described external medicine composition comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae.
2. external medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 30 weight portions ~ 40 weight portions in the described external medicine composition, the Rhizoma Anemarrhenae 70 weight portions ~ 80 weight portions, Rhizoma Phragmitis 60 weight portions ~ 70 weight portions, Radix Arnebiae (Radix Lithospermi) 25 weight portions ~ 35 weight portions, Fructus Arctii 20 weight portions ~ 30 weight portions, Galla Chinensis 40 weight portions ~ 50 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portion Herba Polygoni Avicularis, 25 weight portions ~ 35 weight portions, Semen Phaseoli 35 weight portions ~ 45 weight portions, Fructus Chaenomelis 15 weight portions ~ 25 weight portions, Herba Taraxaci 50 weight portions ~ 60 weight portions, Radix Peucedani 10 weight portions ~ 20 weight portions, Folium Viticis Negundo 25 weight portions ~ 35 weight portions, Radix Scutellariae 85 weight portions ~ 95 weight portions, Radix Sophorae Flavescentis 40 weight portions ~ 50 weight portions, Ramulus et Folium Bauhiniae Faberi 45 weight portions ~ 55 weight portions, Herba Dendrobii 40 weight portions ~ 50 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 30 weight portions ~ 40 weight portions, Radix Codonopsis 45 weight portions ~ 55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portions ~ 40 weight portions, when medicine 20 weight portions ~ 30 weight portion Rhizoma Dioscoreae Septemlobaes, 25 weight portions ~ 35 weight portions, Radix Saposhnikoviae 15 weight portions ~ 25 weight portions, Radix Gentianae 30 weight portions ~ 40 weight portions.
3. external medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 33 weight portions ~ 37 weight portions in the described external medicine composition, the Rhizoma Anemarrhenae 73 weight portions ~ 77 weight portions, Rhizoma Phragmitis 63 weight portions ~ 67 weight portions, Radix Arnebiae (Radix Lithospermi) 28 weight portions ~ 32 weight portions, Fructus Arctii 23 weight portions ~ 27 weight portions, Galla Chinensis 43 weight portions ~ 47 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 33 weight portions ~ 37 weight portion Herba Polygoni Avicularis, 28 weight portions ~ 32 weight portions, Semen Phaseoli 38 weight portions ~ 42 weight portions, Fructus Chaenomelis 18 weight portions ~ 22 weight portions, Herba Taraxaci 53 weight portions ~ 57 weight portions, Radix Peucedani 13 weight portions ~ 17 weight portions, Folium Viticis Negundo 28 weight portions ~ 32 weight portions, Radix Scutellariae 88 weight portions ~ 92 weight portions, Radix Sophorae Flavescentis 43 weight portions ~ 47 weight portions, Ramulus et Folium Bauhiniae Faberi 48 weight portions ~ 52 weight portions, Herba Dendrobii 43 weight portions ~ 47 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 33 weight portions ~ 37 weight portions, Radix Codonopsis 48 weight portions ~ 52 weight portions, the Rhizoma Atractylodis Macrocephalae 33 weight portions ~ 37 weight portions, when medicine 23 weight portions ~ 27 weight portion Rhizoma Dioscoreae Septemlobaes, 28 weight portions ~ 32 weight portions, Radix Saposhnikoviae 18 weight portions ~ 22 weight portions, Radix Gentianae 33 weight portions ~ 37 weight portions.
4. such as the described external medicine composition of claims 1 to 3, it is characterized in that: the dosage form of described external medicine composition is washing liquid, powder, unguentum, oil preparation, tincture, cream, gel.
5. the preparation method of the described external medicine composition of claim 1 to 4 is characterized in that: when the dosage form of described external medicine composition is washing liquid, is specially,
Each crude drug component of described external medicine composition is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.3g/ml ~ 0.6g/ml, obtains washing liquid.
6. the using method of the washing liquid of the preparation method of the described external medicine composition of claim 5 preparation is characterized in that, is specially:
Select the sterile gauze pad that is of moderate size according to the skin lesion area, stick in the affected part, with syringe the Chinese medicine drop is spilt on it again, gauze pad humidity is advisable not drip, how much determine the frequency that gauze pad is changed depending on secretions, if the affected part only has a small amount of secretions, should drip at any time and spill medicinal liquid to keep the humidity of gauze pad, each 20min ~ 30min.
7. the preparation method of the described external medicine composition of claim 1 to 4 is characterized in that: when the dosage form of described external medicine composition is powder, is specially,
The first step, each crude drug component in the described external medicine composition is mixed in proportion, adding is soaked first 20min ~ 40min with respect to the distilled water of 6 ~ 8 times of mixture qualities, pours in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, and obtains filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor of acquisition is filtered again, obtains filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), and regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, obtain the first filtrate;
Second step, with beta-schardinger dextrin-use with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality fully after, slowly add the volatile oil of first step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 1:5, and constantly stirs 1h ~ 2h, behind the cold preservation 24h, filter, spray drying is pulverized, obtain volatile oil embedding thing
The 3rd step, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, and obtains 100 orders ~ 200 purpose powder.
8. the using method of the powder of the preparation method of the described external medicine composition of claim 7 preparation is characterized in that, is specially:
Described powder is added vaseline with respect to 1 ~ 2 times of its quality, transfer and all be applied to aseptic dried sliver, put in the container, after the high pressure steam sterilization sterilization, stick in the affected part, each 20min ~ 30min.
9. external medicine composition washing liquid that is used for the treatment of the infant acute eczema, it is characterized in that: the crude drug of described washing liquid comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae
The preparation method of described washing liquid is specially,
Each crude drug component of described external medicine composition is mixed in proportion, adding is with respect to the distilled water of 6 ~ 8 times of mixture qualities, soak first 20min ~ 40min, pour in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtains volatile oil, remaining water extraction liquid filters, obtain filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor that obtains is filtered again, obtain filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), add the volatile oil that obtains previously, stir, regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, filtrate is concentrated into without the alcohol flavor, and adding distilled water to crude drug concentration is 0.3g/ml ~ 0.6g/ml, obtains washing liquid.
10. external medicine composition washing liquid that is used for the treatment of the infant acute eczema, it is characterized in that: the crude drug of described powder comprises Herba Artemisiae Scopariae, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Radix Arnebiae (Radix Lithospermi), Fructus Arctii, Galla Chinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Polygoni Avicularis, Semen Phaseoli, Fructus Chaenomelis, Herba Taraxaci, Radix Peucedani, Folium Viticis Negundo, Radix Scutellariae, Radix Sophorae Flavescentis, Ramulus et Folium Bauhiniae Faberi, Herba Dendrobii, Ilex purpurea Hassk.[I.chinensis Sims, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, when medicine, Rhizoma Dioscoreae Septemlobae, Radix Saposhnikoviae, Radix Gentianae
The preparation method of described powder is specially,
The first step, each crude drug component of described external medicine composition is mixed in proportion, adding is soaked first 20min ~ 40min with respect to the distilled water of 6 ~ 8 times of mixture qualities, pours in the volatile oil extractor, the way of distillation is extracted volatile oil 4 ~ 6h, obtain volatile oil, remaining water extraction liquid filters, and obtains filtrate, in filtering residue, again add the distilled water with respect to 3 ~ 5 times of its quality, decoct 2h ~ 3h, the decoction liquor of acquisition is filtered again, obtains filtrate, filtrate is merged, adding determining alcohol and be 70% ~ 80% ethanol to alcohol volume content, to account for total liquor capacity be 40% ~ 50% (V/V), and regulating pH value is 7.0 ~ 7.5, leaves standstill precipitate with ethanol, filter, obtain the first filtrate;
Second step, with beta-schardinger dextrin-use with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality fully after, slowly add the volatile oil of first step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4 ~ 1:5, and constantly stirs 1h ~ 2h, behind the cold preservation 24h, filter, spray drying is pulverized, obtain volatile oil embedding thing
The 3rd step, the first filtrate concentrating under reduced pressure is removed all water and ethanol, obtain dried cream powder, spray drying adds the volatile oil embedding thing that second step obtains again, sends in the pulverizer and pulverizes, and sieve, and obtains 100 orders ~ 200 purpose powder.
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| CN104606638A (en) * | 2015-01-30 | 2015-05-13 | 董梅 | Medicine for treating damp-heat type acute eczema and preparation method thereof |
| CN105770230A (en) * | 2016-05-13 | 2016-07-20 | 祁云 | Traditional Chinese medicine for treating acute eczema |
| CN105943795A (en) * | 2016-06-22 | 2016-09-21 | 朱明浩 | Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof |
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| CN101049447A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating acute wetness |
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| CN101049447A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating acute wetness |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104606638A (en) * | 2015-01-30 | 2015-05-13 | 董梅 | Medicine for treating damp-heat type acute eczema and preparation method thereof |
| CN105770230A (en) * | 2016-05-13 | 2016-07-20 | 祁云 | Traditional Chinese medicine for treating acute eczema |
| CN105943795A (en) * | 2016-06-22 | 2016-09-21 | 朱明浩 | Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof |
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