CN104771578A

CN104771578A - Traditional Chinese medicine for treating allergic rhinitis

Info

Publication number: CN104771578A
Application number: CN201510210049.4A
Authority: CN
Inventors: 孙霞
Original assignee: Qingdao Huaren Technology Incubator Co Ltd
Current assignee: Qingdao Huaren Technology Incubator Co Ltd
Priority date: 2015-04-28
Filing date: 2015-04-28
Publication date: 2015-07-15

Abstract

The invention provides traditional Chinese medicine for treating allergic rhinitis. The traditional Chinese medicine for treating the allergic rhinitis is characterized by including orally-taken medicine and external application medicine. The raw materials of the orally-taken medicine include companumoea root, sealwort, remote lemongrass herb, Chinese ephedra, rhizoma bolbostemmae, cocklebur fruit, acanthopanax root, acorus tatarinowii, selaginella tamariscina, safflower carthamus, platycodon grandiflorum, epimedium herb, fructus psoraleae, angelica root, centipeda herb, costus root, capitate knotweed herb and herba lycopi. The raw materials of the external application medicine include reed rhizome, Chinese ephedra, selaginella tamariscina, safflower carthamus, magnolia flower, centipeda herb, Chinese atractylode rhizome, smilax riparia, mint, Chinese pulsatilla root, schizonepeta, white paeony root, poria cocos, dalbergia wood, scutellaria baicalensis and liquorice. By the adoption of the internal and external matched treatment, the main and collateral channels of a patient can be dredged, yang energy of the patient is supplemented, functions of internal organs can be conditioned, the immunity of the patient can be improved, the living quality of the patient can be improved, accordingly perennial allergic rhinitis can be well treated, and the treatment effect is better than pure internal treatment effect.

Description

Be used for the treatment of the Chinese medicine of allergic rhinitis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine being used for the treatment of perennial allergic rhinitis.

Background technology

Allergic rhinitis are global commonly encountered diseases, frequently-occurring disease.According to foreign statistic, sickness rate is about 10% ~ 40%, and in rising trend, and China about has 2,000 ten thousand people ill every year.Along with industrialized development and atmospheric pollution increase the weight of, and global warming, the plant pollen phase shifts to an earlier date, prolongation, and primary disease sickness rate has obvious ascendant trend.What allergic rhinitis patients was the most worried not only has the problem such as sleep, sniffle, also has daily routines and social communication to limit and emotional problem, so allergic rhinitis are not only a medical problem, and Shi Ge social problem.Must be regarded it as serious global health problem.In recent years, although the studying and combating of nasal allergy has had incremental advances, allergic rhinitis have been effectively controlled not yet.Along with improving constantly of allergic rhinitis sickness rate in recent years, have a strong impact on the Health and Living of the mankind, the research of allergic rhinitis and treatment are problems anxious to be resolved at present.

The treatment of current allergic rhinitis is mainly divided into following 4 classes: avoid that contact allergy is former, Drug therapy, immunization therapy (desensitization treatment) and operative treatment.Certainly, optimal treatment is that patient avoids contact allergy former, as the people to animal skin allergy, should avoid raising the house pet such as cat, Canis familiaris L.; In the season that pollen waves, reduce the contact with pollen; Often cleaning and duty shine bedding thoroughly, reduce dirt dragonfly within doors.Although to reduce and the method for avoiding contact allergy former is highly effective, but to avoid contact allergy former be completely impossible; Due to unstability and easy some complication of generation of immune formulation purification, by the expert of ARIA, immunization therapy is not thought that being recommended in developing country uses, and desensitization treatment is very loaded down with trivial details, and the general treatment cycle, a lot of patient was difficult to adhere at about 3 years; Some scholars think when above-mentioned therapeutic effect is undesirable, can consider to apply operative treatment, but late result needs to observe further.Therefore, Most patients needs to use medicine effectively to control allergic rhinitis.At present large class medicine is mainly contained, as antihistaminic, Decongestant, anticholinergic agent, mast cell stabilizers and corticosteroid medication to the class of medications of allergic rhinitis.At present, these medicines be, curative effect relatively long in the clinical practice time certainly and the medicine more deep to Drug side reaction understanding, although there is clinical efficacy in various degree, or side reaction is obvious; Or it is not long to enter the clinical practice time, lack the heightened awareness to toxic and side effects; Or curative effect is unstable.

Allergic rhinitis belong to the category such as " allergic rhinitis " in motherland's medical science, " allergic rhinitis with sneezing ", " water of having a stuffy nose ", clinical with the rhinocnesmus of unexpected or recurrent exerbation, sneeze again and again, the thin nasal discharge cacorhinia that is main manifestations as the disease such as water, nasal obstruction.The Basic disease cause that allergic rhinitis occurs, comprises endogenous cause of ill and exopathogenic factor two aspects: exopathogenic factor is mainly wind, cold, heat criminal nose, foreign body people nose; Endogenous cause of ill is mainly visceral dysfunction, and lung, spleen, kidney three deficiency of five ZANG-organs damage, and are attacked outward by the heresy of wind and cold unusual pathogen.It shows lung, and pathological change and spleen kidney have certain relation.Insufficiency of lung-QI, instability of surface, striae of the skin and muscles being loose, the heresy of wind and cold is outer attacks, and violate and nose key, pathogen conflicting with vital QI, lung qi must not lead to tune, and body fluid stops gathering, and nose key is jammed, and then causes sneeze snivel.Enriching again because of lung qi, depend on the defeated cloth of temper, deficiency of spleen-QI is insufficiency of lung-QI then.And the root of gas is at kidney, suffer from a deficiency of the kidney, take the photograph to receive and have no right, gas does not return unit, and yang-energy is easy to dissipate, and invades pathogenic within ailment said due to cold or exposure obtains.Treatment primary disease is worked as based on treatment by oral administration of medicines replenishing QI to invigorate the spleen; Assistant with tonifying YANG consolidating superficial resistance, the method that cold expelling is sensible, external treatment expelling pathogenic wind and restoring the functions of orifices in face, pungent dispersing wind and cold then.The applicant of the application has developed according to treatment by oral administration of medicines principle the endo-medicine being used for the treatment of perennial allergic rhinitis, and the comparatively conventional Western medicine of clinical manifestation is better.In order to improve the curative effect adopting tcm methods treatment primary disease further, the therapeutic modality combined inside and outside the application adopts, treating both the principal and secondary aspects of a disease, the slight illness of reduction of patient faster while treatment, improve the quality of life of patient, a kind of Chinese medicine being used for the treatment of perennial allergic rhinitis proposed, by for oral administration and external application, with the use of, the meridians of patient can be dredged, supplement the yang-energy of patient, improve the immunity of patient, improve the quality of life of patient, thus better treat perennial allergic rhinitis, more simple treatment by oral administration of medicines better effects if.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of the oral medicinal herb medicine and the liniment that are used for the treatment of perennial allergic rhinitis, and treatment by oral administration of medicines replenishing QI to invigorate the spleen is main; Assistant is with tonifying YANG consolidating superficial resistance, the method that cold expelling is sensible, external treatment expelling pathogenic wind and restoring the functions of orifices in face, pungent dispersing wind and cold then, with the use of, the meridians of patient can be dredged, supplement the yang-energy of patient, conditioning viscera function, improve the immunity of patient, improve the quality of life of patient, thus better treat perennial allergic rhinitis, more simple treatment by oral administration of medicines better effects if.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine being used for the treatment of perennial allergic rhinitis, it is made up of endo-medicine and liniment;

The crude drug of described endo-medicine comprises Radix Campanumoeae, Rhizoma Polygonati, Herba Cymbopogonis, Herba Ephedrae, Rhizoma Bolbostematis, Fructus Xanthii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Selaginellae, Flos Carthami, Radix Platycodonis, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Centipedae, Radix Aucklandiae (Radix Vladimiriae), Herba Polygoni Capitati and red stalk grass;

The crude drug of described liniment comprises Rhizoma Phragmitis, Herba Ephedrae, Herba Selaginellae, Flos Carthami, Flos Magnoliae, Herba Centipedae, Rhizoma Atractylodis, Radix et Rhizoma Smilacis Ripariae, Herba Menthae, the Radix Pulsatillae, Herba Schizonepetae, the Radix Paeoniae Alba, Poria, Lignum Dalbergiae Odoriferae, Herba Parnassiae foliosae, Radix Scutellariae and Radix Glycyrrhizae.

Wherein, in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 35g ~ 45g, Rhizoma Polygonati 25g ~ 35g, Herba Cymbopogonis 5g ~ 15g, Herba Ephedrae 15g ~ 25g, Rhizoma Bolbostematis 15g ~ 25g, Fructus Xanthii 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Rhizoma Acori Graminei 10g ~ 20g, Herba Selaginellae 10g ~ 20g, Flos Carthami 15g ~ 25g, Radix Platycodonis 10g ~ 20g, Herba Epimedii 10g ~ 20g, Fructus Psoraleae 15g ~ 25g, Radix Angelicae Dahuricae 20g ~ 30g, Herba Centipedae 20g ~ 30g, Radix Aucklandiae (Radix Vladimiriae) 10g ~ 20g, Herba Polygoni Capitati 5g ~ 15g and red stalk grass 10g ~ 20g;

In described Traditional Chinese Medicine for external application medicine, the weight of each crude drug is respectively Rhizoma Phragmitis 10g ~ 20g, Herba Ephedrae 35g ~ 45g, Herba Selaginellae 10g ~ 20g, Flos Carthami 15g ~ 25g, Flos Magnoliae 35g ~ 45g, Herba Centipedae 25g ~ 35g, Rhizoma Atractylodis 10g ~ 20g, Radix et Rhizoma Smilacis Ripariae 5g ~ 15g, Herba Menthae 15g ~ 25g, Radix Pulsatillae 20g ~ 30g, Herba Schizonepetae 20g ~ 30g, Radix Paeoniae Alba 15g ~ 25g, Poria 15g ~ 25g, Lignum Dalbergiae Odoriferae 10g ~ 20g, Herba Parnassiae foliosae 5g ~ 15g, Radix Scutellariae 35g ~ 45g and Radix Glycyrrhizae 10g ~ 20g.

Wherein, in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 38g ~ 42g, Rhizoma Polygonati 28g ~ 32g, Herba Cymbopogonis 8g ~ 12g, Herba Ephedrae 18g ~ 22g, Rhizoma Bolbostematis 18g ~ 22g, Fructus Xanthii 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 28g ~ 32g, Rhizoma Acori Graminei 13g ~ 17g, Herba Selaginellae 13g ~ 17g, Flos Carthami 18g ~ 22g, Radix Platycodonis 13g ~ 17g, Herba Epimedii 13g ~ 17g, Fructus Psoraleae 18g ~ 22g, Radix Angelicae Dahuricae 23g ~ 27g, Herba Centipedae 23g ~ 27g, Radix Aucklandiae (Radix Vladimiriae) 13g ~ 17g, Herba Polygoni Capitati 8g ~ 12g and red stalk grass 13g ~ 17g;

In described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 38g ~ 42g, Rhizoma Polygonati 28g ~ 32g, Herba Cymbopogonis 8g ~ 12g, Herba Ephedrae 18g ~ 22g, Rhizoma Bolbostematis 18g ~ 22g, Fructus Xanthii 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 28g ~ 32g, Rhizoma Acori Graminei 13g ~ 17g, Herba Selaginellae 13g ~ 17g, Flos Carthami 18g ~ 22g, Radix Platycodonis 13g ~ 17g, Herba Epimedii 13g ~ 17g, Fructus Psoraleae 18g ~ 22g, Radix Angelicae Dahuricae 23g ~ 27g, Herba Centipedae 23g ~ 27g, Radix Aucklandiae (Radix Vladimiriae) 13g ~ 17g, Herba Polygoni Capitati 8g ~ 12g and red stalk grass 13g ~ 17g.

Wherein, in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 40g, Rhizoma Polygonati 30g, Herba Cymbopogonis 10g, Herba Ephedrae 20g, Rhizoma Bolbostematis 20g, Fructus Xanthii 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Rhizoma Acori Graminei 15g, Herba Selaginellae 15g, Flos Carthami 20g, Radix Platycodonis 15g, Herba Epimedii 15g, Fructus Psoraleae 20g, Radix Angelicae Dahuricae 25g, Herba Centipedae 25g, Radix Aucklandiae (Radix Vladimiriae) 15g, Herba Polygoni Capitati 10g and red stalk grass 15g;

In described Traditional Chinese Medicine for external application medicine, the weight of each crude drug is respectively Rhizoma Phragmitis 15g, Herba Ephedrae 40g, Herba Selaginellae 15g, Flos Carthami 20g, Flos Magnoliae 40g, Herba Centipedae 30g, Rhizoma Atractylodis 15g, Radix et Rhizoma Smilacis Ripariae 10g, Herba Menthae 20g, Radix Pulsatillae 25g, Herba Schizonepetae 25g, Radix Paeoniae Alba 20g, Poria 20g, Lignum Dalbergiae Odoriferae 15g, Herba Parnassiae foliosae 10g, Radix Scutellariae 40g and Radix Glycyrrhizae 15g.

Wherein, described endo-medicine is prepared into tablet, granule, capsule, honey pill agent, powder, water decoction.

Wherein, described liniment is prepared into Emulsion, ointment, tincture, distillate medicinal water, liniment, lotion, liniment or spray etc.

Present invention also offers the preparation method of above-mentioned Chinese medicine, it comprises:

The preparation method of described endo-medicine specifically comprises,

The first step, choose Radix Campanumoeae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Polygoni Capitati and red stalk grass, clean respectively, pulverize, soak with white vinegar, fried dry, is ground into powder;

Second step, cleans respectively by remaining crude drug component, pulverizes, and by water boiling and extraction, obtains extracting solution, and concentrated remove portion water, obtains extractum;

3rd step, the extractum mixing that the powder obtain the first step and second step obtain, adds corresponding adjuvant, is prepared into various regular dosage form.

Wherein, the described first step is specially further chooses Radix Campanumoeae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Polygoni Capitati and red stalk grass, cleans respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soak and endure after 24 hours, fry tack-free with slow fire to be degree, to take out and dry, grind into powder, cross 100 order fine powders, for subsequent use.

Wherein, described second step is specially further to be cleaned respectively by remaining crude drug, pulverizes, puts into container, add the distilled water relative to this step crude drug quality sum 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extracts; Again add relative to this step crude drug quality sum 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add relative to this step crude drug quality sum 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.12 ~ 1.15, for subsequent use.

The preparation method of described liniment specifically comprises,

The first step, pulverizes Herba Menthae, crosses 100 mesh sieves, for subsequent use;

Second step, cleans respectively by remaining crude drug, pulverizes, puts into container, add the distilled water relative to this step crude drug quality sum 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extracts; Again add relative to this step crude drug quality sum 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add relative to this step crude drug quality sum 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, concentrating under reduced pressure, obtain and get dry extract, pulverize, cross 100 mesh sieves;

3rd step, the powder mixing that the powder obtain the first step and second step obtain, end is placed in the water relative to its quality 3 ~ 5 times, stirring and dissolving, to be dissolved completely after add relative to this solution quality 5% surfactant polyethylene 300 quantitative separating in aerosol pressure vessel, enter 2 times of volume propellant tetrafluoroethane at the pressure of 100Kpa, make spray.

Beneficial effect of the present invention:

Oral medicinal herb medicine and the liniment being used for the treatment of perennial allergic rhinitis provided by the invention, treatment by oral administration of medicines replenishing QI to invigorate the spleen is main; Assistant is with tonifying YANG consolidating superficial resistance, the method that cold expelling is sensible, external treatment expelling pathogenic wind and restoring the functions of orifices in face, pungent dispersing wind and cold then, with the use of, the meridians of patient can be dredged, supplement the yang-energy of patient, conditioning viscera function, improve the immunity of patient, improve the quality of life of patient, thus better treat perennial allergic rhinitis, more simple treatment by oral administration of medicines better effects if.

Detailed description of the invention

Allergic rhinitis belong to the category such as " allergic rhinitis " in motherland's medical science, " allergic rhinitis with sneezing ", " water of having a stuffy nose ", this disease be with suddenly and the rhinocnesmus of recurrent exerbation, sneeze take place frequently, watery nasal discharge incessantly, have a stuffy nose as the disease of cardinal symptom.Chinese medical book is own through having had the comparatively understanding of system to its name of disease, etiology and pathogenesis and treatment, and modern doctor is on this basis many, is developed and uses, and think that the endogenous cause of ill of primary disease mostly is lung, spleen, renal dysfunction, the heresy that exopathogenic factor mostly then is wind and cold haunts.Insufficiency of lung-QI, instability of surface, wind and cold is taken advantage of a weak point, and lung qi must not lead to tune, and body fluid stops gathering, and nose key Kui Sai, causes sneeze, snivel then.And the substantial defeated cloth depending on temper of lung qi, deficiency of spleen-QI with the passing of time then must involve in lung, causes insufficiency of lung-QI; The root of gas, at kidney, is suffered from a deficiency of the kidney, and take the photograph to receive and have no right, gas does not return unit, invades pathogenic within ailment said due to cold or exposure obtains.Meanwhile, have doctor to propose battalion and defend imbalance, the invasion and attack of the heresy of wind and cold, make lung meridian be subject to heresy, or dysfunction of the spleen in transportation, clear YANG failing to ascend, and key is clearly disturbed by turbid yin, or because of insufficiency of kidney-YANG, and the mistake of lung spleen is warm and cause and sneeze.Immune function of human body and lung, spleen, kidney three deficiency of five ZANG-organs damage in close relations, and any deficiency of five ZANG-organs of the lung that a variety of causes causes, spleen, kidney damages, and all can affect immune function of human body.Body's immunity is low, is subject to exopathogen invasion and attack, and then induced allergy rhinitis.Treatment primary disease is worked as based on treatment by oral administration of medicines replenishing QI to invigorate the spleen; Assistant with tonifying YANG consolidating superficial resistance, the method that cold expelling is sensible, external treatment expelling pathogenic wind and restoring the functions of orifices in face, pungent dispersing wind and cold then.

The invention provides a kind of Chinese medicine for oral administration medicine being used for the treatment of perennial allergic rhinitis, it comprises Radix Campanumoeae, Rhizoma Polygonati, Herba Cymbopogonis, Herba Ephedrae, Rhizoma Bolbostematis, Fructus Xanthii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Selaginellae, Flos Carthami, Radix Platycodonis, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Centipedae, Radix Aucklandiae (Radix Vladimiriae), Herba Polygoni Capitati and red stalk grass.

Further preferably, described Chinese medicine for oral administration medicine is only prepared from by above-mentioned raw materials medicine.

Fang Zhong, Radix Campanumoeae strengthening the body resistance, the gas of large spleen reinforcing lung, defend consolidating superficial resistance in fact, Rhizoma Polygonati spleen invigorating lung moistening, benefiting QI for strengthening the superficies, Herba Cymbopogonis expelling pathogen from the exterior and eliminating dampness by diuresis, Herba Ephedrae sends out cold inducing sweat, depressed lung-energy dispersing, Rhizoma Bolbostematis eliminating stagnation, detumescence, removing toxic substances, Fructus Xanthii dispelling wind is sensible, Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, expelling wind and removing dampness, Rhizoma Acori Graminei waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, Herba Selaginellae, Flos Carthami blood circulation promoting and blood stasis dispelling, the enlargement for the treatment of concha nasalis, the cough-relieving of Radix Platycodonis lung qi dispersing, Herba Epimedii, Fructus Psoraleae kidney invigorating and YANG supporting, the Radix Angelicae Dahuricae the lucid yang sending up that induces sweat dispels the wind, Herba Centipedae cold-dispelling, clearing the nasal passage, can effectively blocking histamine from the release of mastocyte, the pungent temperature cold expelling of Radix Aucklandiae (Radix Vladimiriae), Herba Polygoni Capitati clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication, the careless promoting blood flow to regulate menstruation of red stalk, stasis-dispelling and pain-killing, all medicines share, play replenishing QI to invigorate the spleen altogether, tonifying YANG consolidating superficial resistance, the merit that cold expelling is sensible.

Each crude drug pharmacology is as follows:

Radix Campanumoeae: latin name radix campanumoea javanicae is the root of campanulaceae leopard platymiscium Campanumoea javanica and leopard, sweet in the mouth, property is put down, and returns lung, spleen channel, has invigorating the spleen and benefiting QI, tonifying the lung and stopping cough, effect of stimulating milk secretion, cure mainly the empty internal injury of labor, the deficiency of vital energy is weak, cardiopalmus, hyperhidrosis, diarrhea due to hypofunction of the spleen, leucorrhea, milk is rare, the cards such as insufficiency of the spleen cough.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Herba Cymbopogonis: acrid in the mouth, micro-hardship, warm in nature, have and induce sweat; Dampness removing; Effect of relieving cough and asthma, cures mainly anemofrigid cold; Sunstroke; Vomit and diarrhoea and suffer from abdominal pain; Urine leaching pain; Rheumatic arthralgia; The cards such as cough and asthma.

Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, is mainly used in the exterior excess syndromes such as the fever without perspiration of affection of exogenous wind-cold; Rheumatic arthralgia pain; Pathogenic cold attacking the lung or accumulation of heat in the lung to cough with asthma QI rising in reverse order, edema, the cards such as dysuria.

Rhizoma Bolbostematis: latin name Bolbostemmatis Rhizoma, bitter in the mouth, cold nature, returns lung, spleen channel, has eliminating stagnation, detumescence, and effect of removing toxic substances, cures mainly acute mastitis, scrofula; Mastitis, lymphoid tuberculosis, chronic lymphadenitis, the cards such as hypertrophic rhinitis.

Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, to dispel the wind the effect of sharp numbness, reducing swelling and alleviating pain, be used for the treatment of expectorant and cover clear key, coma, these product are pungent to be opened bitter dry temperature and leads to, and fragrance is walked to alter, not only there is the merit of refreshment of having one's ideas straightened out, and have removing dampness concurrently, eliminating phlegm, ward off dirty effect therefore be good at that to control the mind that the foul heresy of phlegm-damp hoodwinks key clearly caused dazed and confused; Also retention of dampness in middle-JIAO is used for the treatment of, gastral cavity abdomen feeling of fullness, feeling of distension and oppression pain.These product pungent temperature fragrance, kind removing dampness is turbid, stomach of being amusing, circulation of qi promoting is stagnant, relieving distension is full; Also be used for the treatment of forgetful, insomnia, tinnitus, deaf.

Herba Selaginellae: latin name Selaginellae Herba, be the dry herb of Spikemoss plant Herba Selaginellae or Selaginella pulvinata, acrid in the mouth, property is put down, and returns liver, heart channel, has effect of promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.

Flos Carthami: warm in nature, acrid in the mouth, enters, the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing, and for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection such as to swell and ache the disease.

Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enters lung meridian, has expelling phlegm for arresting cough, and has the effect of lung qi dispersing evacuation of pus, cures mainly the cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Herba Epimedii: acrid in the mouth, sweet, warm in nature, enters liver, kidney channel, has kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling, cold extremities with aversion to cold soft for impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity; The cards such as arthralgia due to cold-dampnes or spasm of the limbs numbness.

Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel, have kidney invigorating and YANG supporting, warming spleen and stopping diarrha effect, cures mainly decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea; Insufficiency of kidney-YANG, spleen soil loses using warming therapy stomachache limb and trembles with fear, the cards such as Diarrhoea.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Herba Centipedae: latin name Centipedae Hebra, acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.

Radix Aucklandiae (Radix Vladimiriae): arduous, warm.Return stomach, spleen, liver, large intestine channel, pungent loose temperature is led to, and can disperse pathogenic cold in abdomen, the stagnant gas in row gastrointestinal, can control the diseases such as the tenesmus of the abdominal distention of QI stagnating in middle-JIAO, inappetence and dysentery.Because being good at regulating QI, all QI stagnated by cold of breast abdomen can being controlled and have a pain, and control the jaundice of QI stagnation of the liver and galibladder, hypochondriac pain and colicky.There is effect of row irritability, reason lung qi.

Herba Polygoni Capitati: be the herb of Polygonaceae arsesmart Herba Polygoni Capitati, bitter in the mouth, pungent, cool in nature, have clearing away heat-damp and promoting diuresis, effect of promoting blood circulation and detoxication, cures mainly dysentery, pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, rheumatalgia, traumatic injury, skin infection, the cards such as eczema.

Red stalk grass: be the herb of the different leaf Herba Lycopi of Compositae feverwort, sweet in the mouth, hardship, slightly warm in nature, returns liver, kidney channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, effect of dehumidifying row water, cures mainly menoxenia, amenorrhea, stomachache, disease that postpartum lochia can't go, edema, traumatic injury, the cards such as fracture.

In described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 35g ~ 45g, Rhizoma Polygonati 25g ~ 35g, Herba Cymbopogonis 5g ~ 15g, Herba Ephedrae 15g ~ 25g, Rhizoma Bolbostematis 15g ~ 25g, Fructus Xanthii 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Rhizoma Acori Graminei 10g ~ 20g, Herba Selaginellae 10g ~ 20g, Flos Carthami 15g ~ 25g, Radix Platycodonis 10g ~ 20g, Herba Epimedii 10g ~ 20g, Fructus Psoraleae 15g ~ 25g, Radix Angelicae Dahuricae 20g ~ 30g, Herba Centipedae 20g ~ 30g, Radix Aucklandiae (Radix Vladimiriae) 10g ~ 20g, Herba Polygoni Capitati 5g ~ 15g and red stalk grass 10g ~ 20g.

Further preferably, in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 38g ~ 42g, Rhizoma Polygonati 28g ~ 32g, Herba Cymbopogonis 8g ~ 12g, Herba Ephedrae 18g ~ 22g, Rhizoma Bolbostematis 18g ~ 22g, Fructus Xanthii 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 28g ~ 32g, Rhizoma Acori Graminei 13g ~ 17g, Herba Selaginellae 13g ~ 17g, Flos Carthami 18g ~ 22g, Radix Platycodonis 13g ~ 17g, Herba Epimedii 13g ~ 17g, Fructus Psoraleae 18g ~ 22g, Radix Angelicae Dahuricae 23g ~ 27g, Herba Centipedae 23g ~ 27g, Radix Aucklandiae (Radix Vladimiriae) 13g ~ 17g, Herba Polygoni Capitati 8g ~ 12g and red stalk grass 13g ~ 17g.

Most preferably, in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 40g, Rhizoma Polygonati 30g, Herba Cymbopogonis 10g, Herba Ephedrae 20g, Rhizoma Bolbostematis 20g, Fructus Xanthii 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Rhizoma Acori Graminei 15g, Herba Selaginellae 15g, Flos Carthami 20g, Radix Platycodonis 15g, Herba Epimedii 15g, Fructus Psoraleae 20g, Radix Angelicae Dahuricae 25g, Herba Centipedae 25g, Radix Aucklandiae (Radix Vladimiriae) 15g, Herba Polygoni Capitati 10g and red stalk grass 15g.

Described Chinese medicine for oral administration medicine can be prepared into various regular dosage form according to conventional methods, as tablet, granule, capsule, honey pill agent, powder, water decoction etc., is preferably prepared into tablet and granule.

Present invention also offers the preparation method of above-mentioned Chinese medicine for oral administration medicine, be specially:

The described first step is specially further chooses Radix Campanumoeae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Polygoni Capitati and red stalk grass, clean respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soaks and endures after 24 hours, and frying tack-free with slow fire is degree, take out and dry, grind into powder, cross 100 order fine powders, for subsequent use.

Described second step is specially further to be cleaned respectively by remaining crude drug, pulverizes, puts into container, add the distilled water relative to this step crude drug quality sum 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extracts; Again add relative to this step crude drug quality sum 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add relative to this step crude drug quality sum 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.12 ~ 1.15, for subsequent use.

When prepared dosage form is tablet, described 3rd step is specially the extractum mixing of powder and the second step acquisition first step obtained further, obtain mixing extractum, take 25g mixing extractum, 30g lactose, 50g PEG6000,90g microcrystalline Cellulose, 15g cross-linked carboxymethyl cellulose, 5g magnesium stearate, granulation, tabletting, make 1000, and every sheet is containing crude drug amount 0.5g.

When prepared dosage form is granule, described 3rd step is specially the extractum mixing of powder and the second step acquisition first step obtained further, obtain mixing extractum, take 25g mixing extractum, add 160g sucrose, 110g powdered flavor, 8% starch slurry 420g granulate, dried particles, granulate, subpackage, every bag containing crude drug amount 0.5g.

Present invention also offers a kind of Traditional Chinese Medicine for external application medicine for coordinating above-mentioned endo-medicine to use treatment perennial allergic rhinitis, its crude drug comprises Rhizoma Phragmitis, Herba Ephedrae, Herba Selaginellae, Flos Carthami, Flos Magnoliae, Herba Centipedae, Rhizoma Atractylodis, Radix et Rhizoma Smilacis Ripariae, Herba Menthae, the Radix Pulsatillae, Herba Schizonepetae, the Radix Paeoniae Alba, Poria, Lignum Dalbergiae Odoriferae, Herba Parnassiae foliosae, Radix Scutellariae and Radix Glycyrrhizae.

Further preferably, described Traditional Chinese Medicine for external application medicine is only prepared from by above-mentioned raw materials medicine.

Fang Zhong, Rhizoma Phragmitis enters lung meridian, dispelling wind and ventilating the lung, eliminating dampness and diuresis, Herba Ephedrae sends out cold inducing sweat, depressed lung-energy dispersing, Herba Selaginellae, Flos Carthami, Pollen Typhae blood circulation promoting and blood stasis dispelling, the enlargement for the treatment of concha nasalis, Flos Magnoliae is apt to clearing the nasal passage, the gas drawing clear sun in stomach rises, through nose key, make nasal cavity unobstructed, Herba Centipedae cold-dispelling, clearing the nasal passage, can effectively blocking histamine from the release of mastocyte, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and dampness, Radix et Rhizoma Smilacis Ripariae dispelling wind and removing obstruction in the collateral, expelling phlegm for arresting cough, the analgesic therapy of Rhizoma Polygoni Cuspidati dissipating blood stasis, preventing phlegm from forming and stopping coughing, Herba Menthae is sensible holds back tears, wind and heat dispersing, Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, Herba Schizonepetae expelling pathogenic wind from the body surface, declare malicious rash, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, Poria promoting diuresis to eliminate damp pathogen, Lignum Dalbergiae Odoriferae promoting flow of QI and blood, analgesic hemostatic, Herba Parnassiae foliosae clearing heat and moistening lung, removing toxic substances and promoting subsidence of swelling, in Radix Scutellariae, Radix Scutellariae have infection and anti-allergic effects, anaphylaxis edema and inflammation can be suppressed, reduce capillary permeability, reduce the burst size of chemical mediator during antigen antibody reaction, thus suppress the excessive secretion of bronchia mucosal, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines play expelling pathogenic wind and restoring the functions of orifices in face altogether, the merit of pungent dispersing wind and cold.

Each crude drug pharmacology is as follows:

Rhizoma Phragmitis: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, effect of YIN nourishing and the production of body fluid promoting, cure mainly the dysphoria with smothery sensation that epidemic febrile disease joins the army point thirsty, dryness of the tongue Tianjin is few, and the rash of measles goes out not saturating, and pathogenic heat violates the cough and expectoration of lung, the cough vomiting pus of lung abscess, the damp and hot card such as vomiting singultus blocked in stomach.

Flos Magnoliae: acrid in the mouth, warm in nature, enter lung, stomach warp; there is effect of expelling wind and cold, understand things pain-stopping, cure mainly headche due to wind-cold, dizzy; nasal sinusitis, nose cold current tears, toothache; the cards such as swelling of the face, Flos Magnoliae merit is apt to lung qi dispersing gas and clearing the nasal passage, is the special medicine for the treatment of nasal sinusitis; pharmacological action shows as protection nasal mucosa, promotes that mucosal secretions absorbs, reduces inflammation; short nasal cavity is unobstructed, antiallergic, anti-dopamine.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, the effect of improving eyesight, be mainly used in the stomachache dysentery of retention of dampness in middle-JIAO, the abdominal distention pain of incoordination between the spleen and stomach, vomits indigestion and loss of appetite; The abdomen side of body distending pain, the vomiting with acid regurgitation of incoordination between the liver and stomach; And the card such as the anemofrigid-damp arthralgia of the outer strongly fragrant meridians of cold-damp.

Pollen Typhae: sweet in the mouth, property is put down, and enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.

Radix et Rhizoma Smilacis Ripariae: warm in nature, sweet in the mouth, micro-hardship, has dispelling wind and removing obstruction in the collateral, expelling phlegm for arresting cough, effect of QI invigorating, cures mainly rheumatism arthromyodynia, impairment caused by overstrain lumbago, traumatic injury, cough and asthma, the cards such as deficiency of vital energy edema.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, returns liver, gallbladder, lung meridian, has the effect of expelling wind and removing dampness, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing, for arthralgia, and jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.

Herba Menthae: acrid in the mouth, cool in nature, enters lung, Liver Channel, there is effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, dispersing the stagnated live-QI to relieve the stagnation of QI, for affection due to external wind and heat or epidemic febrile disease from the beginning of, headache due to pathogenic wind-heat, the many tear of Ramulus et Folium Bischofiae Javanicae, laryngopharynx swelling and pain, measles is sent out not smooth thoroughly, rubella is scratched where it itches, irritability stasis, and uncomfortable in chest not relaxing waits card, Herba Menthae can make blood capillary shrink, alleviate contrafluxion edema, have stronger analgesic effect, promote that inflammatory cells recovers normal.

The Radix Pulsatillae: bitter in the mouth, cold in nature, return stomach, large intestine channel, there is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites, cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, the cards such as scrofula.

Herba Schizonepetae: acrid in the mouth, slightly warm in nature, enters lung, Liver Channel, has expelling pathogenic wind from the body surface, declares malicious rash, and effect for the treatment of blood disorders relieving convulsion cures mainly flu cold and heat, headache, eye itching, pharyngalgia, cough, measles, rubella, carbuncle skin ulcer, brigadier, spit blood, clot blood, has blood in stool, metrorrhagia, the card such as postpartum apoplexy, bruise.

The Radix Paeoniae Alba: bitter in the mouth, acid, cool in nature, return liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior card.

Poria: sweet in the mouth, light, property is put down, and enters spleen, lung, bladder, heart channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, be mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the card such as anorexia and loose stool, phlegm retention stagnation, epilepsy of stagnation of dampness due to deficiency of the spleen.

Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature, return liver, spleen channel, there is promoting flow of QI and blood, effect of analgesic hemostatic.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, the cards such as traumatic hemorrhage.

Herba Parnassiae foliosae: for Saxifragaceae Parnassia plant dashes forward every the herb of Herba parnassiae or root, sweet in the mouth, cold in nature, have clearing heat and moistening lung, effect of removing toxic substances and promoting subsidence of swelling, cures mainly pulmonary tuberculosis, laryngitis, parotitis, lymphadenitis, hot carbuncle toxin, the cards such as traumatic injury.

Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire invades the swollen card of carbuncle sore poison of excessive skin.

Radix Glycyrrhizae: sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

Further preferably, in described Traditional Chinese Medicine for external application medicine, the weight of each crude drug is respectively Rhizoma Phragmitis 13g ~ 17g, Herba Ephedrae 38g ~ 42g, Herba Selaginellae 13g ~ 17g, Flos Carthami 18g ~ 22g, Flos Magnoliae 38g ~ 42g, Herba Centipedae 28g ~ 32g, Rhizoma Atractylodis 13g ~ 17g, Radix et Rhizoma Smilacis Ripariae 8g ~ 12g, Herba Menthae 18g ~ 22g, Radix Pulsatillae 23g ~ 27g, Herba Schizonepetae 23g ~ 27g, Radix Paeoniae Alba 18g ~ 22g, Poria 18g ~ 22g, Lignum Dalbergiae Odoriferae 13g ~ 17g, Herba Parnassiae foliosae 8g ~ 12g, Radix Scutellariae 38g ~ 42g and Radix Glycyrrhizae 13g ~ 17g.

Most preferably, in described Traditional Chinese Medicine for external application medicine, the weight of each crude drug is respectively Rhizoma Phragmitis 15g, Herba Ephedrae 40g, Herba Selaginellae 15g, Flos Carthami 20g, Flos Magnoliae 40g, Herba Centipedae 30g, Rhizoma Atractylodis 15g, Radix et Rhizoma Smilacis Ripariae 10g, Herba Menthae 20g, Radix Pulsatillae 25g, Herba Schizonepetae 25g, Radix Paeoniae Alba 20g, Poria 20g, Lignum Dalbergiae Odoriferae 15g, Herba Parnassiae foliosae 10g, Radix Scutellariae 40g and Radix Glycyrrhizae 15g.

Described Traditional Chinese Medicine for external application medicine can be prepared into Emulsion, ointment, tincture, distillate medicinal water, liniment, lotion, liniment or spray etc. according to customary preparation methods, is preferably prepared into spray.

Present invention also offers the preparation method of above-mentioned Traditional Chinese Medicine for external application medicine, specifically comprise:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet 1

Choose Radix Campanumoeae 40g, Rhizoma Polygonati 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Rhizoma Acori Graminei 15g, Herba Epimedii 15g, Fructus Psoraleae 20g, Radix Angelicae Dahuricae 25g, Herba Polygoni Capitati 10g and red stalk grass 15g, clean respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soak and endure after 24 hours, frying tack-free with slow fire is degree, take out and dry, grind into powder, cross 100 order fine powders, for subsequent use, by Herba Cymbopogonis 10g, Herba Ephedrae 20g, Rhizoma Bolbostematis 20g, Fructus Xanthii 30g, Herba Selaginellae 15g, Flos Carthami 20g, Radix Platycodonis 15g, Herba Centipedae 25g, Radix Aucklandiae (Radix Vladimiriae) 15g cleans respectively, pulverize, put into container, add the distilled water of 1.5kg, soak after 6 hours, boil 4 hours, extract, again add the distilled water of 1.2kg, boil 3 hours, extract, finally, add the distilled water of 800g, heated and boiled 2 hours, extract, merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.15, for subsequent use, the powder obtained and extractum are mixed, obtains mixing extractum, take 25g mixing extractum, 30g lactose, 50g PEG6000,90g microcrystalline Cellulose, 15g cross-linked carboxymethyl cellulose, 5g magnesium stearate, granulation, tabletting, make 1000, and every sheet is containing crude drug amount 0.5g.

Embodiment 2 tablet 2

Choose Radix Campanumoeae 38g, Rhizoma Polygonati 28g, Radix Et Caulis Acanthopanacis Senticosi 28g, Rhizoma Acori Graminei 13g, Herba Epimedii 13g, Fructus Psoraleae 18g, Radix Angelicae Dahuricae 23g, Herba Polygoni Capitati 8g and red stalk grass 13g, clean respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soaks and endures after 24 hours, frying tack-free with slow fire is degree, take out and dry, grind into powder, cross 100 order fine powders, for subsequent use, by Herba Cymbopogonis 8 _g, Herba Ephedrae 18g, Rhizoma Bolbostematis 18g, Fructus Xanthii 28g, Herba Selaginellae 13g, Flos Carthami 18g, Radix Platycodonis 13g, Herba Centipedae 23g, Radix Aucklandiae (Radix Vladimiriae) 13g clean respectively, pulverize, put into container, add the distilled water of 1.5kg, soaks after 6 hours, boil 4 hours, extraction; Again add the distilled water of 1.2kg, boil 3 hours, extract; Finally, add the distilled water of 800g, heated and boiled 2 hours, extract; Merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.15, for subsequent use, the powder obtained and extractum are mixed, obtains mixing extractum, take 25g mixing extractum, 30g lactose, 50g PEG6000,90g microcrystalline Cellulose, 15g cross-linked carboxymethyl cellulose, 5g magnesium stearate, granulation, tabletting, make 1000, and every sheet is containing crude drug amount 0.5g.

Embodiment 3 tablet 3

Choose Radix Campanumoeae 42g, Rhizoma Polygonati 32g, Radix Et Caulis Acanthopanacis Senticosi 32g, Rhizoma Acori Graminei 17g, Herba Epimedii 17g, Fructus Psoraleae 22g, Radix Angelicae Dahuricae 27g, Herba Polygoni Capitati 12g and red stalk grass 17g, clean respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soak and endure after 24 hours, frying tack-free with slow fire is degree, take out and dry, grind into powder, cross 100 order fine powders, for subsequent use, by Herba Cymbopogonis 12g, Herba Ephedrae 22g, Rhizoma Bolbostematis 22g, Fructus Xanthii 32g, Herba Selaginellae 17g, Flos Carthami 22g, Radix Platycodonis 17g, Herba Centipedae 27g, Radix Aucklandiae (Radix Vladimiriae) 17g cleans respectively, pulverize, put into container, add the distilled water of 1.8kg, soak after 6 hours, boil 4 hours, extract, again add the distilled water of 1.5kg, boil 3 hours, extract, finally, add the distilled water of 1kg, heated and boiled 2 hours, extract, merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.15, for subsequent use, the powder obtained and extractum are mixed, obtains mixing extractum, take 25g mixing extractum, 30g lactose, 50g PEG6000,90g microcrystalline Cellulose, 15g cross-linked carboxymethyl cellulose, 5g magnesium stearate, granulation, tabletting, make 1000, and every sheet is containing crude drug amount 0.5g.

Acute toxicity testing

Kunming mice 40 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, female half and half, body weight 18 ~ 22g, at artificial lighting 12h, breeding observing 3d in well-ventilated's situation, be divided into 40 groups at random, 10/group, wherein 1 group of white mice is blank group, three components does not gavage tablet 1 to tablet 3 prepared by the present invention in addition, tablet dissolved is focused in water and gavages, the amount of gavaging is 12000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, observe the poisoning symptom of animal, analyse, observe the change of each histoorgan and core, liver, spleen, kidney, lung and intestinal do pathological section, calculate median lethal dose(LD 50), Continuous Observation 7d, and note down.

After pouring into Chinese medicinal tablet with gastric perfusion needle is oral, individual mice is rolled up in corner, movable reduces, but 2d observes, and 30 mice activities, drinks water and searches for food all normal.After Continuous Observation 7d, 30 mices are all strong alive.The aspect such as spirit, appetite, the colour of skin, secretions, eye, breathing, muscular movement of whole mice, does not all observe ANOMALOUS VARIATIONS, catches and kills mice during off-test, and perusal internal organs change, different without obviously observing from blank group.According to toxicological evaluation standard, LD ₅₀> 10000mg/kg, belong to non-toxic substance, and this test oral dose increases 12000mg/kg, and 30 mices are still strong alive, illustrate that Chinese medicine composition tablet is to mice safety non-toxic.

Long term toxicity test

Cavia porcellus 40 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, be divided into four groups, often organize 10, wherein 1 group of white mice is blank group, and remain 3 groups of tablet 1 to tablets 3 gavaging the present invention respectively and prepare, the amount of gavaging is 400mg (crude drug) kg ^-1gavage 2 every day, successive administration 90 days, observe growth promoter, the behavioral activity of animal, feed water inlet, breathes, body temperature, hematuria is conventional, hepatic and renal function and other reactions, after last administration, blood extracting assay, gross necropsy after putting to death animal also carries out check pathological section to major organs such as the heart, liver, spleen, lung, kidneys, medication has no the every observation index of more than laboratory animal on the 90th and does not occur abnormal change, or animal dead, different without obviously observing from matched group, animal carries out dissecting and does the inspection of each organs and tissues, is showed no abnormal pathologic and changes.

Embodiment 4 granule

Choose Radix Campanumoeae 40g, Rhizoma Polygonati 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Rhizoma Acori Graminei 15g, Herba Epimedii 15g, Fructus Psoraleae 20g, Radix Angelicae Dahuricae 25g, Herba Polygoni Capitati 10g and red stalk grass 15g, clean respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soak and endure after 24 hours, frying tack-free with slow fire is degree, take out and dry, grind into powder, cross 100 order fine powders, for subsequent use, by Herba Cymbopogonis 10g, Herba Ephedrae 20g, Rhizoma Bolbostematis 20g, Fructus Xanthii 30g, Herba Selaginellae 15g, Flos Carthami 20g, Radix Platycodonis 15g, Herba Centipedae 25g, Radix Aucklandiae (Radix Vladimiriae) 15g cleans respectively, pulverize, put into container, add the distilled water of 1.5kg, soak after 6 hours, boil 4 hours, extract, again add the distilled water of 1.2kg, boil 3 hours, extract, finally, add the distilled water of 800g, heated and boiled 2 hours, extract, merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.15, for subsequent use, the powder obtained and extractum are mixed, obtains mixing extractum, take 25g mixing extractum, add 160g sucrose, 110g powdered flavor, 8% starch slurry 420g granulate, dried particles, granulate, subpackage, every bag containing crude drug amount 0.5g.

Embodiment 5 spray 1

Herba Menthae 20g is pulverized, cross 100 mesh sieves, for subsequent use, Rhizoma Phragmitis 15g, Herba Ephedrae 40g, Herba Selaginellae 15g, Flos Carthami 20g, Flos Magnoliae 40g, Herba Centipedae 30g, Rhizoma Atractylodis 15g, Radix et Rhizoma Smilacis Ripariae 10g, Radix Pulsatillae 25g, Herba Schizonepetae 25g, Radix Paeoniae Alba 20g, Poria 20g, Lignum Dalbergiae Odoriferae 15g, Herba Parnassiae foliosae 10g, Radix Scutellariae 40g and Radix Glycyrrhizae 15g are cleaned respectively, pulverizes, put into container, add the distilled water of 3.2kg, soak after 6 hours, boil 4 hours, extract; Again add the distilled water of 2.5kg, boil 3 hours, extract; Finally, add 1.8kg distilled water, heated and boiled 2 hours, extract; Merge three extracting solution, filter, obtain filtrate, concentrating under reduced pressure, obtain and get dry extract, pulverize, cross 100 mesh sieves, by the powder mixing obtained above, end is placed in the water relative to its quality 5 times, stirring and dissolving, to be dissolved completely after add relative to this solution quality 5% surfactant polyethylene 300 quantitative separating in aerosol pressure vessel, enter 2 times of volume propellant tetrafluoroethane at the pressure of 100Kpa, make spray.

Embodiment 6 spray 2

Herba Menthae 18g is pulverized, cross 100 mesh sieves, for subsequent use, Rhizoma Phragmitis 13g, Herba Ephedrae 38g, Herba Selaginellae 13g, Flos Carthami 18g, Flos Magnoliae 38g, Herba Centipedae 28g, Rhizoma Atractylodis 13g, Radix et Rhizoma Smilacis Ripariae 8g, Radix Pulsatillae 23g, Herba Schizonepetae 23g, Radix Paeoniae Alba 18g, Poria 18g, Lignum Dalbergiae Odoriferae 13g, Herba Parnassiae foliosae 8g, Radix Scutellariae 38g and Radix Glycyrrhizae 13g are cleaned respectively, pulverizes, put into container, add the distilled water of 3kg, soak after 6 hours, boil 4 hours, extract; Again add the distilled water of 2.5kg, boil 3 hours, extract; Finally, add 1.5kg distilled water, heated and boiled 2 hours, extract; Merge three extracting solution, filter, obtain filtrate, concentrating under reduced pressure, obtain and get dry extract, pulverize, cross 100 mesh sieves, by the powder mixing obtained above, end is placed in the water relative to its quality 5 times, stirring and dissolving, to be dissolved completely after add relative to this solution quality 5% surfactant polyethylene 300 quantitative separating in aerosol pressure vessel, enter 2 times of volume propellant tetrafluoroethane at the pressure of 100Kpa, make spray.

Embodiment 7 spray 3

Herba Menthae 22g is pulverized, cross 100 mesh sieves, for subsequent use, Rhizoma Phragmitis 17g, Herba Ephedrae 42g, Herba Selaginellae 17g, Flos Carthami 22g, Flos Magnoliae 42g, Herba Centipedae 32g, Rhizoma Atractylodis 17g, Radix et Rhizoma Smilacis Ripariae 12g, Radix Pulsatillae 27g, Herba Schizonepetae 27g, Radix Paeoniae Alba 22g, Poria 22g, Lignum Dalbergiae Odoriferae 17g, Herba Parnassiae foliosae 12g, Radix Scutellariae 42g and Radix Glycyrrhizae 17g are cleaned respectively, pulverizes, put into container, add the distilled water of 3.5kg, soak after 6 hours, boil 4 hours, extract; Again add the distilled water of 2.5kg, boil 3 hours, extract; Finally, add 2kg distilled water, heated and boiled 2 hours, extract; Merge three extracting solution, filter, obtain filtrate, concentrating under reduced pressure, obtain and get dry extract, pulverize, cross 100 mesh sieves, by the powder mixing obtained above, end is placed in the water relative to its quality 5 times, stirring and dissolving, to be dissolved completely after add relative to this solution quality 5% surfactant polyethylene 300 quantitative separating in aerosol pressure vessel, enter 2 times of volume propellant tetrafluoroethane at the pressure of 100Kpa, make spray.

Acute toxicity testing

Kunming mice 40 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, female half and half, body weight 18 ~ 22g, at artificial lighting 12h, breeding observing 3d in well-ventilated's situation, be divided into 40 groups at random, 10/group, wherein 1 group of white mice is blank group, three components does not gavage spray 1 to spray 3 prepared by the present invention in addition, described spray is the spray solution be not also sub-packed in embodiment 5-7 in aerosol pressure vessel, the amount of gavaging is 12000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, observe the poisoning symptom of animal, analyse, observe the change of each histoorgan and core, liver, spleen, kidney, lung and intestinal do pathological section, calculate median lethal dose(LD 50), Continuous Observation 7d, and note down.

After pouring into Traditional Chinese medicine composition-type spray with gastric perfusion needle is oral, individual mice is rolled up in corner, movable reduces, but 2d observes, and 30 mice activities, drinks water and searches for food all normal.After Continuous Observation 7d, 30 mices are all strong alive.The aspect such as spirit, appetite, the colour of skin, secretions, eye, breathing, muscular movement of whole mice, does not all observe ANOMALOUS VARIATIONS, catches and kills mice during off-test, and perusal internal organs change, different without obviously observing from blank group.According to toxicological evaluation standard, LD ₅₀> 10000mg/kg, belong to non-toxic substance, and this test oral dose increases 12000mg/kg, and 30 mices are still strong alive, illustrate that Traditional Chinese medicine composition-type spray is to mice safety non-toxic.

Long term toxicity test

Cavia porcellus 40 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, be divided into four groups, often organize 10, wherein 1 group of white mice is blank group, remains 3 groups of spray 1 to sprays 3 gavaging the present invention respectively and prepare, described spray is the spray solution be not also sub-packed in embodiment 5-7 in aerosol pressure vessel, and the amount of gavaging is 400mg (crude drug) kg ^-1gavage 2 every day, successive administration 90 days, observe growth promoter, the behavioral activity of animal, feed water inlet, breathes, body temperature, hematuria is conventional, hepatic and renal function and other reactions, after last administration, blood extracting assay, gross necropsy after putting to death animal also carries out check pathological section to major organs such as the heart, liver, spleen, lung, kidneys, medication has no the every observation index of more than laboratory animal on the 90th and does not occur abnormal change, or animal dead, different without obviously observing from matched group, animal carries out dissecting and does the inspection of each organs and tissues, is showed no abnormal pathologic and changes.

Irritant experiment

Kunming mice 20 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, female half and half, body weight 18 ~ 22g, is divided into four groups, wherein, one group as blank group, residue three components does not spray into spray 1 to spray 3 prepared by the present invention in nasal cavity, and each nasal cavity respectively sprays 5 times, makes medicinal liquid contact at least 4h with the nasal mucosa of animal, then after 24h, put to death animal, take out local mucosa tissues and observe.Result shows, the nasal mucosa of this group laboratory animal without red and swollen, congested phenomenon, compared with naive animals, no significant difference, thus prove that spray prepared by the present invention has no stimulation.

Skin allergy is tested

Cavia porcellus 30 (being provided by Qingdao City's laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, is fixed by Cavia porcellus, reject body surface 3 × 3cm by hair, spray spray 1 to spray 3 prepared by the present invention respectively, every day 3 times, under each spray 5-10, continuous use 7 days, time result shows, skin allergy experiment, for negative, proves that spray of the present invention can not produce anaphylaxis.

Embodiment 8 clinical data

Physical data

Have collected my Out-patient Department altogether from March, 2012 to 2013 year December and meet hals,Nasen und Ohrenheilkunde branch of Chinese Medical Association of Chinese Journal of Otorhinolaryngology Head And Neck Surgery editorial board " principle of diagnosis and treatment of allergic rhinitis and suggested design " (2004, Lanzhou) diagnostic criteria case totally 270 examples.Be divided into test group, contrast 1 group and contrast 2 groups, test group 90 example, wherein male 53 example, women 37 example, the age (32.3 ± 5.1) year, scope 20 ~ 50 years old, the course of disease (6.22 ± 1.03) year, scope 1 ~ 15 year.Contrast 1 group 90 example, wherein male 52 example, women 38 example, the age (33.1 ± 4.6) year, scope 20 ~ 45 years old, the course of disease (5.40 ± 0.98) year, scope 2 ~ 16 years.Contrast 2 group 90 example, wherein male 49 example, women 41 example, the age (31.2 ± 3.9) year, scope 20 ~ 47 years old, the course of disease (5.21 ± 1.17) year, scope 2 ~ 17 years.

Serum measurements

Each group of patient all extracts limosis vein blood 2mL in early morning, and the blood specimen of TIgE, sICAM-1, IL-4 to be checked is placed in without anticoagulant dry test-tube, and after leaving standstill 30min under room temperature, the centrifugal 20min of 2000r/min, separation of serum, puts in-30 DEG C of refrigerators frozen to be measured.TIgE, sICAM-1, IL-4 measure and adopt enzyme-linked immunosorbent assay (ELISA) method, and detection kit is the brilliant U.S. Products in Shenzhen, and strict by specification requires operation.

Therapeutic Method

Tablet 1 prepared by the oral embodiment of the present invention 1 of test group, each 3, every day each 1 time sooner or later, simultaneously, the spray 1 that every day prepares to nasal cavity spray embodiment 5, each every nostril, side 1 is sprayed (often spraying 128 μ g), every day 2 times, every day total amount 512 μ g, contrast tablet 1 prepared by 1 group of oral embodiment of the present invention 1, each 3, every day each 1 time sooner or later, contrast 2 groups every day oral loratadine 10mg, each 5mg, sooner or later each 1 time, simultaneously, the spray 1 that every day prepares to nasal cavity spray embodiment 5, each every nostril, side 1 is sprayed (often spraying 128 μ g), every day 2 times, every day total amount 512 μ g, an each group of equal 30 days course for the treatment of, continuous treatment 30 days.

Efficacy evaluation

Efficacy assessment standard: (with reference to hals,Nasen und Ohrenheilkunde branch of Chinese Journal of Otorhinolaryngology Head And Neck Surgery editorial board Chinese Medical Association " principle of diagnosis and treatment of allergic rhinitis and suggested design (2004, Lanzhou) " in the efficacy assessment standard recommended) according to the summation of sings and symptoms score before and after treatment, the percentage rate of improvement is by following formulae discovery determination curative effect:

Before treatment, at the end of total score-treatment, before treatment, total score >=66% is effective, and 65% ~ 26% is that effectively≤25% is invalid.

In treatment, whether close observation has the untoward reaction such as epistaxis, xeromycteria, perforation of nasal septum, hyposmia.

Statistics

Adopt SPSS 13.0 systems soft ware process data, measurement data is used ( ) represent, compare employing one factor analysis of variance between group, enumeration data adopts χ ²inspection, P < 0.05 has statistical significance for difference.

Result

Clinical efficacy comparison, the results are shown in Table 1.

Table 1 three groups of Clinical efficacy comparisons

Group	Number of cases	Effective	Effectively	Invalid	Effective percentage
						Test group	90	65	22	3	96.7％
Contrast 1 group	90	46	32	12	86.7％
						Contrast 2 groups	90	29	41	20	77.8％

As can be seen from Table 1, adopt the clinical effectiveness of endo-medicine of the present invention and liniment partner treatment patient will apparently higher than the simple curative effect using the patient of endo-medicine, P < 0.01, and be significantly higher than the clinical efficacy adopting Western medicine loratadine to coordinate the patient of liniment, P < 0.01.

Each group of observation Serum Indexes compares

Each group of TIgE (IU/ml) blood serum values compares, and the results are shown in Table 2.

Table 2 is respectively organized TIgE (IU/ml) blood serum values and is compared

Group	Number of cases	Before treatment	After treatment
				Test group	90	471.69±51.93	205.71±39.89
Contrast 1 group	90	468.25±43.15	273.22±41.86
				Contrast 2 groups	90	475.29±46.72	301.39±40.71

As can be seen from Table 2, with contrast 1 group with contrast 2 groups and compare, adopt medicine internal and external application provided by the invention, can better suppress IgE to produce, to immunoreation, there is dual regulation.

Each group of IL-4 (pg/ml) blood serum values compares, and the results are shown in Table 3.

Table 3 is respectively organized IL-4 (pg/ml) blood serum values and is compared

Group	Number of cases	Before treatment	After treatment
				Test group	90	59.21±6.15	34.16±5.83
Contrast 1 group	90	57.53±5.93	41.35±4.96
				Contrast 2 groups	90	58.37±5.06	43.29±5.06

As can be seen from Table 3, with contrast 1 group with contrast 2 groups and compare, adopt medicine internal and external application provided by the invention, better can promote the decline of IL-4.

Each group of sICAM-1 (μ g/L) blood serum values compares, and the results are shown in Table 4.

Table 4 is respectively organized sICAM-1 (μ g/L) blood serum values and is compared

Group	Number of cases	Before treatment	After treatment
				Test group	90	257.61±36.99	133.95±30.29
Contrast 1 group	90	255.23±35.17	165.29±29.85
				Contrast 2 groups	90	251.19±29.76	179.81±32.26

As can be seen from Table 4, with contrast 1 group with contrast 2 groups and compare, adopt medicine internal and external application provided by the invention, can better reduce sICAM-1 value.

Untoward reaction, the results are shown in Table 5.

Table 5 untoward reaction situation compares

Group	Mucosa is dry	Epistaxis
			Test group	0	0
Contrast 1 group	3	0
			Contrast 2 groups	2	1

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. be used for the treatment of a perennial allergic rhinitis's Chinese medicine, it is characterized in that: be made up of endo-medicine and liniment;

2. Chinese medicine as claimed in claim 1, it is characterized in that: in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 35g ~ 45g, Rhizoma Polygonati 25g ~ 35g, Herba Cymbopogonis 5g ~ 15g, Herba Ephedrae 15g ~ 25g, Rhizoma Bolbostematis 15g ~ 25g, Fructus Xanthii 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Rhizoma Acori Graminei 10g ~ 20g, Herba Selaginellae 10g ~ 20g, Flos Carthami 15g ~ 25g, Radix Platycodonis 10g ~ 20g, Herba Epimedii 10g ~ 20g, Fructus Psoraleae 15g ~ 25g, Radix Angelicae Dahuricae 20g ~ 30g, Herba Centipedae 20g ~ 30g, Radix Aucklandiae (Radix Vladimiriae) 10g ~ 20g, Herba Polygoni Capitati 5g ~ 15g and red stalk grass 10g ~ 20g,

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that: in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 38g ~ 42g, Rhizoma Polygonati 28g ~ 32g, Herba Cymbopogonis 8g ~ 12g, Herba Ephedrae 18g ~ 22g, Rhizoma Bolbostematis 18g ~ 22g, Fructus Xanthii 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 28g ~ 32g, Rhizoma Acori Graminei 13g ~ 17g, Herba Selaginellae 13g ~ 17g, Flos Carthami 18g ~ 22g, Radix Platycodonis 13g ~ 17g, Herba Epimedii 13g ~ 17g, Fructus Psoraleae 18g ~ 22g, Radix Angelicae Dahuricae 23g ~ 27g, Herba Centipedae 23g ~ 27g, Radix Aucklandiae (Radix Vladimiriae) 13g ~ 17g, Herba Polygoni Capitati 8g ~ 12g and red stalk grass 13g ~ 17g,

4. the Chinese medicine as described in claims 1 to 3, is characterized in that: in described endo-medicine, the weight of each crude drug is respectively Radix Campanumoeae 40g, Rhizoma Polygonati 30g, Herba Cymbopogonis 10g, Herba Ephedrae 20g, Rhizoma Bolbostematis 20g, Fructus Xanthii 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Rhizoma Acori Graminei 15g, Herba Selaginellae 15g, Flos Carthami 20g, Radix Platycodonis 15g, Herba Epimedii 15g, Fructus Psoraleae 20g, Radix Angelicae Dahuricae 25g, Herba Centipedae 25g, Radix Aucklandiae (Radix Vladimiriae) 15g, Herba Polygoni Capitati 10g and red stalk grass 15g;

5. the Chinese medicine as described in Claims 1-4, is characterized in that: described endo-medicine is prepared into tablet, granule, capsule, honey pill agent, powder, water decoction.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that: described liniment is prepared into Emulsion, ointment, tincture, distillate medicinal water, liniment, lotion, liniment or spray etc.

7. the preparation method of Chinese medicine described in claim 1 to 6, is characterized in that, comprising:

The preparation method of described endo-medicine specifically comprises,

8. the preparation method of Chinese medicine described in claim 7, is characterized in that: the described first step is specially further chooses Radix Campanumoeae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Herba Epimedii, Fructus Psoraleae, the Radix Angelicae Dahuricae, Herba Polygoni Capitati and red stalk grass, cleans respectively, pulverize, mix, be immersed in white vinegar, white vinegar covers mixture surface, soak and endure after 24 hours, fry tack-free with slow fire to be degree, to take out and dry, grind into powder, cross 100 order fine powders, for subsequent use.

9. the preparation method of Chinese medicine described in claim 7 or 8, it is characterized in that: described second step is specially further to be cleaned respectively by remaining crude drug, pulverize, put into container, add the distilled water relative to this step crude drug quality sum 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add relative to this step crude drug quality sum 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add relative to this step crude drug quality sum 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, under simmer down to 60 DEG C of environment, relative density is the thick paste of 1.12 ~ 1.15, for subsequent use.

10. the preparation method of Chinese medicine described in claim 7 to 9, is characterized in that:

The preparation method of described liniment specifically comprises,