CN103705856B - For preventing the Chinese medicine composition of chemicotherapy acute radio-reaction - Google Patents

Abstract

The invention provides a kind of for preventing the Chinese medicine composition of chemicotherapy acute radio-reaction, its crude drug comprises Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae.This Chinese medicine composition curative effect is good, have no side effect, can as the adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemicotherapy, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for the Comprehensive Treatment of malignant tumor presents good prospect.

Description

For preventing the Chinese medicine composition of chemicotherapy acute radio-reaction

Technical field

The present invention relates to technical field of Chinese medicine, particularly relating to a kind of for preventing the Chinese medicine composition of chemicotherapy acute radio-reaction.

Background technology

The tumor of head and neck occurred frequently of nasopharyngeal carcinoma system south China and Asia Chinese ethnic group.The cause of disease is relevant with factors such as ebv infection, heredity and environmental pollutions, radiotherapy is current effective first-selected Therapeutic Method, single radiotherapy means treatment Advanced Nasopharyngeal Carcinoma case 5 ~ 10 years survival rates only have about 40%, and chemicals synchronous therapeutic III/IV phase nasopharyngeal carcinoma has become the standard method improving curative effect, many employing platinum classes are main treated with combined medication at present, and chemoradiotherapy plus treatment can improve survival rate, reduces local recurrence and reduce metastasis incidence rate.

Although chemo-radiotherapy concomitant therapy curative effect is certain, but relevantization, the increase of radiotherapy toxicity are also affirmatives, because acute toxic reaction increases its radiotherapy unplanned property therapy discontinued, often affect the treatment, drug toxicity summation action also have impact on life in patients simultaneously, although particularly adopt accurate radiotherapy can reduce the damage of high-risk organ at present, radiotherapy mucosa injury then increases because of dose relationship, particularly adds and by chemotherapy, the operability of putting of III/IV phase nasopharyngeal carcinoma synchronous therapeutic is affected.Therefore, how to improve side reaction and to improve the operability of scheme, and making life quality improve the important directions having become nasopharyngeal carcinoma research.

The side reaction of nasopharyngeal carcinoma not only affects the continuity of patients ' life quality, treatment, even jeopardizes patient vitals time serious.The idea of current therapy of combining Chinese and Western medicine tumor has been universally accepted and has achieved the effect of affirmative, Chinese medicine is coordinated to improve patients symptomatic in nasopharyngeal carcinoma process, alleviate Radiotherapy chemotherapy side reaction, improve patients ' life quality, strengthen the confidence of patient's continual cure.

Nasopharyngeal carcinoma belongs to Chinese medicine " cervical carcinoma with cachexia ", " glanders ", " nasal sinusitis ", categories such as " carbuncle on the left mastoid region ", lonizing radiation are as the hot kill agent of one, damage oral cavity, throat mucosa and salivary gland, be equivalent to the so-called pathogenic heat invasion of the traditional Chinese medical science, inside and outside pyretic toxicity, beset by troubles combination, fire-transformation burns Tianjin, first there is the symptom of body fluid being damaged, along with the increase of exit dose, the pyretic toxicity stasis of blood is amassed, " pathogenic heat easily causes skin infection ", oral mucosa local or skin mucosa ulcer are suppurated, hurt like hell, with the passing of time pathogenic heat damages healthy energy, thus cause people's bromhidrosis deficiency of YIN, local deficiency of body fluid, often show as xerostomia clinically, dry laryngopharynx pain, resembling of one yin asthenia generating intrinsic heat such as dysphagia." gathering of heresy, its gas must empty ", therefore the basic pathogenesis " deficiency of YIN be this, and pathogenic dryness is mark " after Radiotherapy for Nasopharyngeal Carcinoma, the cohesion of the pyretic toxicity expectorant stasis of blood, healthy energy is impaired, vital QI being weakened and pathogen being violent run through disease all the time, pathological changes can relate to lung, spleen, stomach three are dirty.

Chinese medicine thinks that nasopharyngeal carcinoma polyphyly expectorant, poison, heat are pented up, and radiotherapy is high strong method of attacking heresy, the many genus of the side reaction after radiotherapy " pyretic toxicity pents up " category, and clinical is principle for the treatment of mainly with nourishing YIN and clearing away heat.But have the tongue of some patients not red or red deep red, and see greasy and thin fur, Ye Hui main suit's xerostomia, this is that prolonged illness injures taste, failure of the spleen to transport and transform because patient's ferritic is weak, body fluid can not cause by normal defeated cloth.Therefore in treatment can not simply with nourishing YIN and clearing away heat removing toxic substances for method, and should according to patients with clinical manifestations, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Spleen is the source of vital function day after tomorrow, therefore invigorating the spleen and benefiting QI, nourishing the stomach to promote the production of body fluid occupy critical role equally.

The present invention with nourishing YIN and clearing away heat removing toxic substances, invigorating the spleen and benefiting QI nourishing the stomach is for Therapeutic Principle, there is provided a kind of for preventing the Chinese medicine composition of chemicotherapy acute radio-reaction, its curative effect is good, have no side effect, can as the adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemicotherapy, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for the Comprehensive Treatment of malignant tumor presents good prospect.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of for preventing the Chinese medicine composition of chemicotherapy acute radio-reaction, its curative effect is good, have no side effect, can as the adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemicotherapy, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for the Comprehensive Treatment of malignant tumor presents good prospect.

For solving the problems of the technologies described above, the invention provides a kind of for preventing the Chinese medicine composition of chemicotherapy acute radio-reaction, its crude drug comprises Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae.

Wherein, in described Chinese medicine composition, the weight of each crude drug is respectively Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Radix Codonopsis 70g ~ 80g, Fructus Ligustri Lucidi 45g ~ 55g, Rhizoma Belamcandae 30g ~ 40g, Semen Coicis 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Rhizoma Coptidis 55g ~ 65g, Herba Houttuyniae 25g ~ 35g, Rhizoma Anemarrhenae 30g ~ 40g, Radix Rubiae 30g ~ 40g, Caulis Bambusae In Taenia 25g ~ 35g, Herba Agrimoniae 35g ~ 45g, Radix Angelicae Sinensis 20g ~ 30g, Radix Paeoniae Rubra 30g ~ 40g, Flos Chrysanthemi 35g ~ 45g, Rhizoma Curcumae 25g ~ 35g, Herba Selaginellae 30g ~ 40g, Radix Pseudostellariae 35g ~ 45g, Ramulus Uncariae Cum Uncis 30g ~ 40g, Rhizoma Dioscoreae 20g ~ 30g, Chimonanthusn itens Oliv. 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 35g, Isodon ternifolius 30g ~ 40g, Herba Eleusines Indicae 25g ~ 35g, Conyza japonica 30g ~ 40g, Herba Hyperici Sampsonii 15g ~ 25g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Fructus Jujubae 20g ~ 30g and Semen Cuscutae 30g ~ 40g.

Wherein, in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g ~ 65g, Radix Codonopsis 75g ~ 80g, Fructus Ligustri Lucidi 50g ~ 55g, Rhizoma Belamcandae 35g ~ 40g, Semen Coicis 30g ~ 35g, Herba Dendrobii 35g ~ 40g, Rhizoma Coptidis 60g ~ 65g, Herba Houttuyniae 30g ~ 35g, Rhizoma Anemarrhenae 35g ~ 40g, Radix Rubiae 35g ~ 40g, Caulis Bambusae In Taenia 30g ~ 35g, Herba Agrimoniae 40g ~ 45g, Radix Angelicae Sinensis 20g ~ 25g, Radix Paeoniae Rubra 30g ~ 35g, Flos Chrysanthemi 35g ~ 40g, Rhizoma Curcumae 25g ~ 30g, Herba Selaginellae 30g ~ 35g, Radix Pseudostellariae 35g ~ 40g, Ramulus Uncariae Cum Uncis 30g ~ 35g, Rhizoma Dioscoreae 20g ~ 25g, Chimonanthusn itens Oliv. 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 30g, Isodon ternifolius 30g ~ 35g, Herba Eleusines Indicae 25g ~ 30g, Conyza japonica 30g ~ 35g, Herba Hyperici Sampsonii 15g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 25g, Fructus Jujubae 20g ~ 25g and Semen Cuscutae 30g ~ 35g.

Wherein, in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Rhizoma Belamcandae 35g, Semen Coicis 30g, Herba Dendrobii 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Radix Rubiae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Flos Chrysanthemi 40g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g.

Wherein, described Chinese medicine composition can be prepared into capsule and oral liquid.

Present invention also offers above-mentioned for preventing the preparation method of the Chinese medicinal composition capsules agent of chemicotherapy acute radio-reaction, being specially:

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak after 3-5 hour and distill 3-5 hours, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, add the ethanol extraction 3-5 hour that determining alcohol is 70%-80%, the amount of alcohol added is 3-5 times of described Chinese medicine composition each crude drug quality sum, and extracting solution filters, filtrate is concentrated into the mastic that relative density is 1.25 ~ 1.30 (65 DEG C), lets cool;

3rd step, gets the above-mentioned mastic of 500g, and the excipient starch adding 1kg-2kg is mixed into soft material, sieves and granulates and in 55-65 DEG C of drying, obtain granule after granulate, then adds the volatile oil of first step acquisition, encapsulated.

Present invention also offers above-mentioned for preventing the preparation method of the Chinese medicine composition oral liquid of chemicotherapy acute radio-reaction, being specially:

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, extracting in water 3-5 hours, the water yield added is 6-8 times of described Chinese medicine composition each crude drug quality sum, extracting solution filters, be concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours, get supernatant reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds volatile oil prepared by the first step, tween 80 and appropriate correctives, adjustment volume is to 1000ml, filter, subpackage, sterilizing, obtain described oral liquid.

Present invention also offers a kind of for preventing the Chinese medicinal composition capsules agent of chemicotherapy acute radio-reaction, its crude drug comprises Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae;

The preparation method of described capsule is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, add the ethanol extraction 3-5 hour that determining alcohol is 70%-80%, the amount of alcohol added is 3-5 times of described Chinese medicine composition each crude drug quality sum, and extracting solution filters, filtrate is concentrated into the mastic that relative density is 1.25 ~ 1.30 (65 DEG C), lets cool;

3rd step, gets the above-mentioned mastic of 500g, and the excipient starch adding 1kg-2kg is mixed into soft material, sieves and granulates and in 55-65 DEG C of drying, obtain granule after granulate, then adds the volatile oil of first step acquisition, encapsulated.

Present invention also offers a kind of for preventing the Chinese medicine composition oral liquid of chemicotherapy acute radio-reaction, its crude drug comprises Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae;

The preparation method of described Chinese medicine composition oral liquid is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, extracting in water 3-5 hour, the water yield added is 6-8 times of described Chinese medicine composition each crude drug quality sum, extracting solution filters, be concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours, get supernatant reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds volatile oil prepared by the first step, tween 80 and appropriate correctives, adjustment volume is to 1000ml, filter, subpackage, sterilizing, obtain described oral liquid.

Beneficial effect of the present invention:

Chinese medicine composition curative effect provided by the invention is good, have no side effect, can as the adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemicotherapy, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for the Comprehensive Treatment of malignant tumor presents good prospect.

Detailed description of the invention

The invention provides a kind of week in the Chinese medicine composition of prevention chemicotherapy acute radio-reaction, its crude drug comprises Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae.

Further, described Chinese medicine composition is only made up of above-mentioned raw materials medicine.

In described Chinese medicine composition, the weight of each crude drug is respectively Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Radix Codonopsis 70g ~ 80g, Fructus Ligustri Lucidi 45g ~ 55g, Rhizoma Belamcandae 30g ~ 40g, Semen Coicis 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Rhizoma Coptidis 55g ~ 65g, Herba Houttuyniae 25g ~ 35g, Rhizoma Anemarrhenae 30g ~ 40g, Radix Rubiae 30g ~ 40g, Caulis Bambusae In Taenia 25g ~ 35g, Herba Agrimoniae 35g ~ 45g, Radix Angelicae Sinensis 20g ~ 30g, Radix Paeoniae Rubra 30g ~ 40g, Flos Chrysanthemi 35g ~ 45g, Rhizoma Curcumae 25g ~ 35g, Herba Selaginellae 30g ~ 40g, Radix Pseudostellariae 35g ~ 45g, Ramulus Uncariae Cum Uncis 30g ~ 40g, Rhizoma Dioscoreae 20g ~ 30g, Chimonanthusn itens Oliv. 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 35g, Isodon ternifolius 30g ~ 40g, Herba Eleusines Indicae 25g ~ 35g, Conyza japonica 30g ~ 40g, Herba Hyperici Sampsonii 15g ~ 25g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Fructus Jujubae 20g ~ 30g and Semen Cuscutae 30g ~ 40g.

Further preferably, in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g ~ 65g, Radix Codonopsis 75g ~ 80g, Fructus Ligustri Lucidi 50g ~ 55g, Rhizoma Belamcandae 35g ~ 40g, Semen Coicis 30g ~ 35g, Herba Dendrobii 35g ~ 40g, Rhizoma Coptidis 60g ~ 65g, Herba Houttuyniae 30g ~ 35g, Rhizoma Anemarrhenae 35g ~ 40g, Radix Rubiae 35g ~ 40g, Caulis Bambusae In Taenia 30g ~ 35g, Herba Agrimoniae 40g ~ 45g, Radix Angelicae Sinensis 20g ~ 25g, Radix Paeoniae Rubra 30g ~ 35g, Flos Chrysanthemi 35g ~ 40g, Rhizoma Curcumae 25g ~ 30g, Herba Selaginellae 30g ~ 35g, Radix Pseudostellariae 35g ~ 40g, Ramulus Uncariae Cum Uncis 30g ~ 35g, Rhizoma Dioscoreae 20g ~ 25g, Chimonanthusn itens Oliv. 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 30g, Isodon ternifolius 30g ~ 35g, Herba Eleusines Indicae 25g ~ 30g, Conyza japonica 30g ~ 35g, Herba Hyperici Sampsonii 15g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 25g, Fructus Jujubae 20g ~ 25g and Semen Cuscutae 30g ~ 35g.

Most preferably, in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Rhizoma Belamcandae 35g, Semen Coicis 30g, Herba Dendrobii 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Radix Rubiae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Flos Chrysanthemi 40g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g.

The pharmacology of each crude drug is as follows:

Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name AcanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

Radix Codonopsis: sweet in the mouth, property is put down, and returns lung, spleen channel, has QI invigorating strengthening the spleen, the symptoms such as effect of nourishing blood to promote the production of body fluid, cures mainly the fatigue and weakness of deficiency of both the splenic and pulmonary QI or QI and blood deficiency, breathes hard, cough spontaneous perspiration, spleen reinforcing nourishing the stomach is longer than by Radix Codonopsis, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property put down, spleen invigorating fortune and not dry; Flavour is cloudy and do not wet, and can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes that intestinal is to the absorption of nutrient substance.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, be mainly used in treat hepatic and renal YIN deficiency, the head lose foster dizzy ear toot, the symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.

Rhizoma Belamcandae: bitter in the mouth, cold in nature, return lung, Liver Channel, there is heat-clearing and toxic substances removing, the effect of clearing away phlegm sore-throat relieving, for the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, the cards such as cough and asthma.

Semen Coicis: sweet in the mouth, property are light, return spleen, stomach, lung meridian, have effect of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, cure mainly dysuria, edema, beriberi, lung abscess, acute appendicitis, rheumatic arthralgia, the cards such as muscle arteries and veins contraction urgency and damp-warm diseases.

Herba Dendrobii: cold nature, sweet in the mouth, enters stomach, kidney channel, has reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat, and for consumption of body fluid by heat, low grade fever excessive thirst, the few tongue of red tongue, deficiency of stomach-Yin, thirsty and dry pharynx, vomiting is eaten less, vague epigastralgia, the few tongue of tongue light, deficiency of kidney yin, the cards such as blurring of vision.

Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, lung, gallbladder, stomach, large intestine channel, have effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, is longer than the fire of removing pathogen in the heart warp, cures mainly the prosperous caused dysphoria and insomnia of heart-fire, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for damp and hot caused dysentery, tenesmus; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis.

Herba Houttuyniae: latin name houttuybiae adds rba, acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, and for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, and snakeworm wants first-class card.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.

Radix Rubiae: cold in nature, bitter in the mouth, has cooling blood for hemostasis, an effect that blood stasis dispelling stimulates the menstrual flow, especially suitable for the hemorrhage of bleeding due to blood-heat, the congestion person that holds concurrently, for stasis of blood stagnate-closed warp, the cards such as postpartum stagnation stomachache, treating swelling and pain by traumatic injury, rheumatic arthralgia.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth, attaches to the lung and stomach meridians, and has removing heat-phlegm, the effect relieved restlessness and prevented vomiting, and holds the card such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.

Herba Agrimoniae: latin name AgrimoniaeHerba, bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, there is astringing to arrest bleeding, effect of dysentery relieving parasite killing, cure mainly various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.

Radix Angelicae Sinensis: latin name angelicaesinensisradix, sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel, having enriches blood invigorates blood circulation, and regulating menstruation relieves the pain, effect of loosening bowel to relieve constipation, and the head curing mainly deficiency of heart-blood is giddy, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood.The sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, measures the cards such as phase that spread out less.

Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, returns Liver Channel, has removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain of high liver fire, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, and macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Various pain caused by blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.

Flos Chrysanthemi: latin name ChrysanthemiFlos, acrid in the mouth, sweet, bitter, cold nature, returns lung, Liver Channel, there is effect of dispelling wind liver heat removing, suppressing the hyperactive liver improving eyesight, removing toxic substances and promoting subsidence of swelling, cure mainly affection due to external wind and heat and epidemic febrile disease from the beginning of, have a dizzy spell, blurring of vision, conjunctival congestion and swelling pain, the cards such as pyretic toxicity carbuncle.

Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, enter liver, spleen channel, have removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving, for the lump in the abdomen mass in the abdomen of caused by energy stagnation and blood stasis, breast abdomen stasis of blood pain, amenorrhea, dysmenorrhea, abdominal distention, traumatic injury, blood stasis such as to swell and ache at the card.

Herba Selaginellae: latin name SelaginellaeHerba is the dry herb of Spikemoss plant Herba Selaginellae or Selaginella pulvinata: acrid in the mouth, property is put down, and returns liver, heart channel, has effect of promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea.WEIJIA mass in the abdomen, injury from falling down, spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and return spleen, lung meridian, have effect of air making-up and spleen enlivening, the lung moistening and production of body fluid promoting, cure mainly the inappetence caused by deficiency-weakness of spleen-QI, fatigue and weakness, deficiency of the lung cough caused by dryness, dyspnea with rapid and short breath is breathed hard, the convalescent stage of febrile disease, and gas Tianjin two is hindered, and interior-heat is thirsty waits card.

Ramulus Uncariae Cum Uncis: sweet in the mouth, slightly warm in nature, enters Liver Channel, has the effect of heat clearing away, suppressing the hyperactive liver and subsiding YANG, relieving spasm by subduing liver-wind, and be mainly used in the anxious raw wind of heat or the caused spasm of liver-wind stirring up internally, twitch, restlessness, excessive rising of liver-YANG or Liver Channel have the headache of heat dizzy, the symptoms such as conjunctival congestion and swelling pain.

Rhizoma Dioscoreae: latin name dioscoreaerhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Chimonanthusn itens Oliv.: be the leaf of Calycanthaceae wax-cakes bait plant Chimonanthusn itens Oliv., acrid in the mouth, micro-hardship, warm in nature, have expelling pathogenic wind from the body surface, removing dampness by means of aromatics, cure mainly influenza, heatstroke, chronic bronchitis, wet tired uncomfortable in chest, mosquito ant fourth such as to sting at the card.

Folium et Caulis Indigoferae Tinctoriae: be the stem and leaf of pulse family anil Folium et Caulis Indigoferae Tinctoriae, mildly bitter flavor, cold in nature, have heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, cures mainly encephalitis B, parotitis, acute pharyngolaryngitis, lymphadenitis, conjunctival congestion, aphtha, erysipelas, worm venom, the cards such as haematemesis.

Dioscorea subcalva Prain et Burhll: acrid in the mouth, warm in nature, there is invigorating the spleen and benefiting QI, effect of invigorating the lung and the kidney, cure mainly insufficiency of the spleen lack of appetite, have loose bowels, emission due to deficiency of the kidney, quench one's thirst, lung impairment and cough, the cards such as traumatic injury.

Herba Eleusines Indicae: sweet in the mouth, light, cool in nature, has heat-clearing and toxic substances removing, dampness removing, effect of cool the blood dissipate blood stasis, and cure mainly Sunstroke heating, infantile convulsion, encephalitis b, epidemic encephalitis, jaundice, stranguria, dysuria, dysentery, has blood in stool, the cards such as traumatic injury.

Conyza japonica: bitter in the mouth, pungent, cold in nature, have clearing away heat to alleviate pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis, pneumonia, laryngopharynx swelling and pain, the cards such as tonsillitis.

Radix et Rhizoma Rhei Franzenbachii: latin name RadixetRhizomeRheiFranzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.

Herba Hyperici Sampsonii: be the herb of Guttiferae hypericum Herba Hyperici Sampsonii, bitter in the mouth, pungent, cold in nature, return liver, spleen channel, there is removing pathogenic heat from blood and toxic substance from the body, promoting blood flow to regulate menstruation, effect of dispelling wind and removing obstruction in the collateral, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, carbuncle furunculosis, scalds, venom, menoxenia, dysmenorrhea, leucorrhea, traumatic injury, rheumatic arthralgia, the cards such as aphtha.

Fructus Jujubae: latin name jujubaefructus, sweet in the mouth, warm in nature, return spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, separate effect of poison of drug, cure mainly insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, and married woman's stolen goods are hot-tempered waits card.

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizzy ear toot; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the cards such as aqueous-grainy diarrhea.

All medicine compatibilities, reinforcement and elimination in combination, with Miles' operation, decoction being taken warmly is taken in small doses at short intervals, and avoids gastrointestinal reaction; Slowly swallow, make medicine juice fully be infiltrated the impaired mucosa of oropharynx, promote that it heals.Found that: in (1) chemicotherapy, the acute radio-reaction of oropharyngeal mucosae and gastronintestinal system obviously alleviates, to reduce patient suffering, ensure that radiotherapy is enough according to plan and complete smoothly; (2) the blood system side reaction caused by chemicotherapy significantly alleviates; (3) certain protective role is had to hepatic and renal function; (4) interrupt natural law because of side reaction in Patients During Radiotherapy obviously to reduce.

Chinese medicine composition provided by the invention can be prepared into capsule and oral liquid.

Present invention also offers above-mentioned for preventing the preparation method of the Chinese medicinal composition capsules agent of chemicotherapy acute radio-reaction, being specially:

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak after 3-5 hour and distill 3-5 hours, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, add the ethanol extraction 3-5 hour that determining alcohol is 70%-80%, the amount of alcohol added is 3-5 times of described Chinese medicine composition each crude drug quality sum, and extracting solution filters, filtrate is concentrated into the mastic that relative density is 1.25 ~ 1.30 (65 DEG C), lets cool;

3rd step, gets the above-mentioned mastic of 500g, and the excipient starch adding 1kg-2kg is mixed into soft material, sieves and granulates and in 55-65 DEG C of dryings, obtain granule after granulate, then adds the volatile oil of first step acquisition, encapsulated.

Present invention also offers above-mentioned for preventing the preparation method of the Chinese medicine composition oral liquid of chemicotherapy acute radio-reaction, being specially:

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak after 3-5 hour and distill 3-5 hours, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, extracting in water 3-5 hour, the water yield added is 6-8 times of described Chinese medicine composition each crude drug quality sum, extracting solution filters, be concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours, get supernatant reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds volatile oil prepared by the first step, tween 80 and appropriate correctives, adjustment volume is to 1000ml, filter, subpackage, sterilizing, obtain described oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 oral liquid 1

By Rhizoma Belamcandae 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Flos Chrysanthemi 40g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g pulverizes respectively, mixing, obtains mixture, adds the water of 3.6kg, and soak after 5 hours and distill 5 hours, collect volatile oil, medicinal residues are for subsequent use, by Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Semen Coicis 30g, Herba Dendrobii 35g, Radix Rubiae 35g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g pulverizes respectively, put into extract continuously and fill with, add the medicinal residues obtained again above, add 4kg water extraction 5 hours, extracting solution filters, be concentrated into relative density 1.10 (60 DEG C), static 24 hours, get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds the volatile oil obtained above, tween 80 and appropriate correctives, adjustment volume is to 1000ml, and filter, subpackage, sterilizing, obtains described oral liquid 1.

Embodiment 2 oral liquid 2

By Rhizoma Belamcandae 40g, Rhizoma Coptidis 65g, Herba Houttuyniae 35g, Rhizoma Anemarrhenae 40g, Caulis Bambusae In Taenia 35g, Herba Agrimoniae 45g, Flos Chrysanthemi 40g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g pulverizes respectively, mixing, obtains mixture, adds the water of 4kg, and soak after 5 hours and distill 5 hours, collect volatile oil, medicinal residues are for subsequent use, by Radix Et Caulis Acanthopanacis Senticosi 65g, Radix Codonopsis 80g, Fructus Ligustri Lucidi 55g, Semen Coicis 35g, Herba Dendrobii 40g, Radix Rubiae 40g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g pulverizes respectively, put into extract continuously and fill with, add the medicinal residues obtained again above, add 4kg water extraction 5 hours, extracting solution filters, be concentrated into relative density 1.10 (60 DEG C), static 24 hours, get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds the volatile oil obtained above, tween 80 and appropriate correctives, adjustment volume is to 1000ml, and filter, subpackage, sterilizing, obtains described oral liquid 2.

Embodiment 3 oral liquid 3

By Rhizoma Belamcandae 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Flos Chrysanthemi 35g, Chimonanthusn itens Oliv. 25g, Folium et Caulis Indigoferae Tinctoriae 25g, Isodon ternifolius 30g, Herba Eleusines Indicae 25g, Conyza japonica 30g, Herba Hyperici Sampsonii 15g pulverizes respectively, mixing, obtains mixture, adds the water of 3.6kg, and soak after 5 hours and distill 5 hours, collect volatile oil, medicinal residues are for subsequent use, by Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Semen Coicis 30g, Herba Dendrobii 35g, Radix Rubiae 35g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 30g, Rhizoma Curcumae 25g, Herba Selaginellae 30g, Radix Pseudostellariae 35g, Ramulus Uncariae Cum Uncis 30g, Rhizoma Dioscoreae 20g, Radix et Rhizoma Rhei Franzenbachii 20g, Fructus Jujubae 20g and Semen Cuscutae 30g pulverizes respectively, put into extract continuously and fill with, add the medicinal residues obtained again above, add 4kg water extraction 5 hours, extracting solution filters, be concentrated into relative density 1.10 (60 DEG C), static 24 hours, get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant to filter, filtrate adds the volatile oil obtained above, tween 80 and appropriate correctives, adjustment volume is to 1000ml, and filter, subpackage, sterilizing, obtains described oral liquid 3.

Embodiment 4 capsule

By Rhizoma Belamcandae 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Flos Chrysanthemi 40g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g pulverizes respectively, mixing, obtains mixture, adds the water of 3.6kg, and soak after 5 hours and distill 5 hours, collect volatile oil, medicinal residues are for subsequent use, by Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Semen Coicis 30g, Herba Dendrobii 35g, Radix Rubiae 35g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g pulverizes respectively, puts into extract continuously and fills with, then add the medicinal residues obtained above, add the ethanol extraction 5 hours that 2.5kg determining alcohol is 80%, extracting solution filters, and filtrate is concentrated into the mastic that relative density is 1.30 (65 DEG C), lets cool, get the above-mentioned mastic of 500g, the excipient starch adding 1kg is mixed into soft material, sieves and granulates and in 55 DEG C of dryings, obtain granule after granulate, add the volatile oil obtained again above, encapsulated.

Toxicological experiment

Acute toxicity test:

Choose NIH kind mice 20, male and female half and half, body weight is 21.33 ± 1.97g by the dosage gastric infusion of 40ml/kg, one day twice, observe seven, phenomenon without exception, without dead, body weight increases to 28.19 ± 2.33g comparatively weightening finish 32.16% before administration.

The oral liquid clinical medicine dose of Chinese medicine composition of the present invention is 10ml × 2=20ml every day, adult's body weight is by 60kg, the oral dose of being then grown up is 20ml/60kg=0.334ml/kg, and it is 40 × 2=80ml/kg that mice is daily measured, and the 80/0.334=240 of suitable people's consumption doubly.

The oral liquid formulations of Chinese medicine composition of the present invention is oral ampulla, selects NIH kind mice 10, and with the every dosage tail vein injection only of 0.5mL, 8-10 at the uniform velocity injects second, observes 72 hours, phenomenon without exception, without dead.

Result of the test shows: the oral liquid toxicity of Chinese medicine composition of the present invention is less.

Long term toxicity test:

The Wistar rat 60 of experimental animal: 7-8 health in age in week, male and female half and half.Observe one week before test, adopt randomized blocks that rat is divided into three groups, often organize 20, male and female half and half, sub-cage rearing.Periodic logging rats eating amount, freely drinks water.Claim a body weight weekly.

Tested material and dosage: oral liquid 1 prepared by embodiment 1

Dosage group is the requirement by acute toxicity testing result and new Chinese medicine toxicologic study guide, if height two dosage groups and a matched group.High dose is 1200g/kg, and be equivalent to 70 times of clinical application amount, low dose group is 500g/kg, is equivalent to 30 times of clinical application amount.Route of administration and method: adopt administration by gavage.Every day 1 time, 6 days weekly, amount to 8 weeks.Body weight change adjustment dosage is pressed weekly during administration.

Observation index:

Ordinary circumstance: observe outward appearance sign every day, behavioral activity, urine excrement situation, food-intake.Weigh weekly and observe change.

Hematological examination: often organize and get 10 rats (male and female half and half) at random, before administration, after administration the 4th week and the 8th week, at tail venous blood sampling, the indexs such as erythrocyte, leukocyte classification, platelet, reticulocyte and content of hemoglobin are tested by " national Clinical Laboratory rule of operation " requirement.

Rat is dissected and histopathologic examination: experiment terminates, often organize and get 10 rats (male and female half and half), thigh blood vessel sacrificed by exsanguination, conventional dissection, observe the mode of appearance of each internal organs, color etc., and the internal organs such as the heart, liver, spleen, lung, kidney, brain are weighed, calculate the percentage ratio of itself and body weight, i.e. organ coefficient.Then pathology method process routinely, does the histopathologic examination of the heart, liver, spleen, lung, kidney, brain and femur.

Result:

General state and body weight change: during administration, each treated animal general state, movable normal, no abnormality seen reacts.Administration group is substantially close with matched group food-intake.Administration group and matched group body weight growth trend basically identical, illustrate that long term administration has no significant effect growth of animal.Male Mus or female Mus each administration group weight gain value compared with matched group, no significant difference (P>0.05).

Hematological indices: height, end dosage group erythrocyte, platelet, platelet and content of hemoglobin before administration, after administration 4 weeks and 8 weeks, compared with matched group, P>0.05, illustrates that medicine has no significant effect above-mentioned each index.

Histopathologic examination: off-test, rat is dissected, and does not find the obvious change of the organs such as the heart, liver, spleen, lung, kidney, brain.Histopathologic examination does not also find that there is pathological change, shows long term administration to each organs and tissues without obvious damage.

Brief summary:

Within continuous 8 weeks, pour into the oral liquid 1 of embodiment 1 preparation to rat oral, dosage is 70 times and 30 times of quantity, and rat general state is good, performance without exception, and each group bodyweight difference, without significance, has no significant effect rat normal growth.

Administration in continuous 8 weeks, blood index is not remarkable, illustrates that oral liquid 1 long term toxicity test result prepared by embodiment 1 shows, finds no pathological change.

Above result of the test shows, oral liquid 1 life-time service provided by the invention, without overt toxicity, is safer Chinese medicine preparation.

Clinical data

Physical data

In March, 2008 ~ 2012 accept advanced NPC patient 101 example for medical treatment year October altogether, and selected patients is first visit and makes a definite diagnosis through histopathology, without former Nasopharyngeal Carcinoma Patients of metastasis, clinical stages III, IVa phase, at 20 ~ 75 years old age, without serious cardiac disorder, hepatic and renal function is normal.Random number method is adopted 101 routine patients to be divided into experimental group 52 example, patient age 20 ~ 70 years old, 45 years old mean age; Matched group 49 example, patient age 22 ~ 71 years old, 46 years old mean age.Two groups of case physical data differences nonsignificance (P<0.05), have comparability.

Method

Radiation therapy method

All patients all accepts radiotherapy, and radioactive source is linear accelerator 6 ~ 8MV photon line and 8 ~ 12Mev electron ray, adopts the method that conventional fractionation irradiates, each 2Gy, every day 1 time, 5 times weekly, center, nasopharynx target area dosage 68 ~ 72Gy; Cervical region radical cure dosage 60 ~ 66Gy, preventive dose 50 ~ 52Gy.

Embolic chemotherapy

All patients all adopts cisplatin (DDP) to carry out the chemotherapy same period.DDP dosage and usage: 30mg/m ², add 3% sodium chloride solution 500ml intravenous drip, from radiotherapy the 1st week, 1 time weekly, totally 6 times.

Medication

Matched group Dobell's sol rinsing the mouth, every day 5 ~ 8 times, terminates to radiotherapy from radiotherapy.Experimental group takes oral liquid 1 prepared by the embodiment of the present invention 1, and every day, 20ml, took at twice, terminates to radiotherapy from radiotherapy.

Oropharynx reaction diagnostic criteria

0 degree: oral mucosa is normal; I degree: erythema, pain appear in oral mucosa; II degree: erythema, ulcer appear in oral mucosa, can enter general diet; III degree: stomatocace, can only eat by influent stream; IV degree: occur ulcer, patient can not take food.

Statistical method

Adopt SPSS10.0 statistical software, enumeration data rate relatively use χ ²inspection, ranked data non parametric tests rank test.

Result

Two groups of oropharynx acute toxicities compare, and the results are shown in Table 1.

A situation arises compares n (%) for two groups of oropharynx acute toxicities

Group	n	0 grade	I level	II level	III level	IV level
							Experimental group	52	0	29(55.77)	18(34.62)	5(9.62)	0(0)
Matched group	49	0	2(4.08)	17(34.69)	22(44.89)	8(16.33)

As can be seen from Table 1, experimental group is obviously little compared with matched group oropharynx acute toxicity incidence rate.

More than two groups of III degree oropharynx acute reaction time of origin compares, and the results are shown in Table 2.

It is more than table 2 liang group III degree that oropharynx acute reaction time of origin compares n (%)

Group	n	In radiotherapy 14d	After radiotherapy 14d
				Experimental group	5	1(20)	4(80)
Matched group	30	12(40)	18(60)

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. for preventing a Chinese medicine composition for chemicotherapy acute radio-reaction, it is characterized in that: crude drug is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae;

The weight of each crude drug is respectively Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Radix Codonopsis 70g ~ 80g, Fructus Ligustri Lucidi 45g ~ 55g, Rhizoma Belamcandae 30g ~ 40g, Semen Coicis 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Rhizoma Coptidis 55g ~ 65g, Herba Houttuyniae 25g ~ 35g, Rhizoma Anemarrhenae 30g ~ 40g, Radix Rubiae 30g ~ 40g, Caulis Bambusae In Taenia 25g ~ 35g, Herba Agrimoniae 35g ~ 45g, Radix Angelicae Sinensis 20g ~ 30g, Radix Paeoniae Rubra 30g ~ 40g, Flos Chrysanthemi 35g ~ 45g, Rhizoma Curcumae 25g ~ 35g, Herba Selaginellae 30g ~ 40g, Radix Pseudostellariae 35g ~ 45g, Ramulus Uncariae Cum Uncis 30g ~ 40g, Rhizoma Dioscoreae 20g ~ 30g, Chimonanthusn itens Oliv. 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 35g, Isodon ternifolius 30g ~ 40g, Herba Eleusines Indicae 25g ~ 35g, Conyza japonica 30g ~ 40g, Herba Hyperici Sampsonii 15g ~ 25g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Fructus Jujubae 20g ~ 30g and Semen Cuscutae 30g ~ 40g.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g ~ 65g, Radix Codonopsis 75g ~ 80g, Fructus Ligustri Lucidi 50g ~ 55g, Rhizoma Belamcandae 35g ~ 40g, Semen Coicis 30g ~ 35g, Herba Dendrobii 35g ~ 40g, Rhizoma Coptidis 60g ~ 65g, Herba Houttuyniae 30g ~ 35g, Rhizoma Anemarrhenae 35g ~ 40g, Radix Rubiae 35g ~ 40g, Caulis Bambusae In Taenia 30g ~ 35g, Herba Agrimoniae 40g ~ 45g, Radix Angelicae Sinensis 20g ~ 25g, Radix Paeoniae Rubra 30g ~ 35g, Flos Chrysanthemi 35g ~ 40g, Rhizoma Curcumae 25g ~ 30g, Herba Selaginellae 30g ~ 35g, Radix Pseudostellariae 35g ~ 40g, Ramulus Uncariae Cum Uncis 30g ~ 35g, Rhizoma Dioscoreae 20g ~ 25g, Chimonanthusn itens Oliv. 25g ~ 30g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 30g, Isodon ternifolius 30g ~ 35g, Herba Eleusines Indicae 25g ~ 30g, Conyza japonica 30g ~ 35g, Herba Hyperici Sampsonii 15g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 25g, Fructus Jujubae 20g ~ 25g and Semen Cuscutae 30g ~ 35g.

3. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described Chinese medicine composition, the weight of each component is respectively Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Codonopsis 75g, Fructus Ligustri Lucidi 50g, Rhizoma Belamcandae 35g, Semen Coicis 30g, Herba Dendrobii 35g, Rhizoma Coptidis 60g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 35g, Radix Rubiae 35g, Caulis Bambusae In Taenia 30g, Herba Agrimoniae 40g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 35g, Flos Chrysanthemi 40g, Rhizoma Curcumae 30g, Herba Selaginellae 35g, Radix Pseudostellariae 40g, Ramulus Uncariae Cum Uncis 35g, Rhizoma Dioscoreae 25g, Chimonanthusn itens Oliv. 30g, Folium et Caulis Indigoferae Tinctoriae 30g, Isodon ternifolius 35g, Herba Eleusines Indicae 30g, Conyza japonica 35g, Herba Hyperici Sampsonii 20g, Radix et Rhizoma Rhei Franzenbachii 25g, Fructus Jujubae 25g and Semen Cuscutae 35g.

4. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition is prepared into capsule and oral liquid.

5. described in claim 1 or 2 for preventing the preparation method of the Chinese medicine composition of chemicotherapy acute radio-reaction, it is characterized in that: the dosage form of described Chinese medicine composition is capsule, and preparation method is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, add the ethanol extraction 3-5 hour that determining alcohol is 70%-80%, the amount of alcohol added is 3-5 times of described Chinese medicine composition each crude drug quality sum, and extracting solution filters, when filtrate is concentrated into 65 DEG C, relative density is the mastic of 1.25 ~ 1.3, lets cool;

3rd step, gets the above-mentioned mastic of 500g, and the excipient starch adding 1kg-2kg is mixed into soft material, sieves and granulates and in 55-65 DEG C of drying, obtain granule after granulate, then adds the volatile oil of first step acquisition, encapsulated.

6. described in claim 1 or 2 for preventing the preparation method of the Chinese medicine composition of chemicotherapy acute radio-reaction, it is characterized in that: the dosage form of described Chinese medicine composition is oral liquid, and preparation method is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, extracting in water 3-5 hour, the water yield added is 6-8 times of described Chinese medicine composition each crude drug quality sum, extracting solution filters, relative density 1.10-1.12 when being concentrated into 60 DEG C, static 24 hours, get relative density 1.04 when supernatant reclaims ethanol and is concentrated into 20 DEG C, leave standstill 48 hours, get supernatant to filter, filtrate adds volatile oil prepared by the first step, tween 80 and appropriate correctives, adjustment volume is to 1000ml, filter, subpackage, sterilizing, obtain described oral liquid.

7., for preventing a Chinese medicinal composition capsules agent for chemicotherapy acute radio-reaction, it is characterized in that: crude drug is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae;

The weight of each crude drug is respectively Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Radix Codonopsis 70g ~ 80g, Fructus Ligustri Lucidi 45g ~ 55g, Rhizoma Belamcandae 30g ~ 40g, Semen Coicis 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Rhizoma Coptidis 55g ~ 65g, Herba Houttuyniae 25g ~ 35g, Rhizoma Anemarrhenae 30g ~ 40g, Radix Rubiae 30g ~ 40g, Caulis Bambusae In Taenia 25g ~ 35g, Herba Agrimoniae 35g ~ 45g, Radix Angelicae Sinensis 20g ~ 30g, Radix Paeoniae Rubra 30g ~ 40g, Flos Chrysanthemi 35g ~ 45g, Rhizoma Curcumae 25g ~ 35g, Herba Selaginellae 30g ~ 40g, Radix Pseudostellariae 35g ~ 45g, Ramulus Uncariae Cum Uncis 30g ~ 40g, Rhizoma Dioscoreae 20g ~ 30g, Chimonanthusn itens Oliv. 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 35g, Isodon ternifolius 30g ~ 40g, Herba Eleusines Indicae 25g ~ 35g, Conyza japonica 30g ~ 40g, Herba Hyperici Sampsonii 15g ~ 25g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Fructus Jujubae 20g ~ 30g and Semen Cuscutae 30g ~ 40g,

The preparation method of described capsule is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, add the ethanol extraction 3-5 hour that determining alcohol is 70%-80%, the amount of alcohol added is 3-5 times of described Chinese medicine composition each crude drug quality sum, and extracting solution filters, when filtrate is concentrated into 65 DEG C, relative density is the mastic of 1.25 ~ 1.30, lets cool;

3rd step, gets the above-mentioned mastic of 500g, and the excipient starch adding 1kg-2kg is mixed into soft material, sieves and granulates and in 55-65 DEG C of drying, obtain granule after granulate, then adds the volatile oil of first step acquisition, encapsulated.

8., for preventing a Chinese medicine composition oral liquid for chemicotherapy acute radio-reaction, it is characterized in that: crude drug is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Fructus Ligustri Lucidi, Rhizoma Belamcandae, Semen Coicis, Herba Dendrobii, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Radix Rubiae, Caulis Bambusae In Taenia, Herba Agrimoniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Chrysanthemi, Rhizoma Curcumae, Herba Selaginellae, Radix Pseudostellariae, Ramulus Uncariae Cum Uncis, Rhizoma Dioscoreae, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica, Herba Hyperici Sampsonii, Radix et Rhizoma Rhei Franzenbachii, Fructus Jujubae and Semen Cuscutae;

The weight of each crude drug is respectively Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Radix Codonopsis 70g ~ 80g, Fructus Ligustri Lucidi 45g ~ 55g, Rhizoma Belamcandae 30g ~ 40g, Semen Coicis 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Rhizoma Coptidis 55g ~ 65g, Herba Houttuyniae 25g ~ 35g, Rhizoma Anemarrhenae 30g ~ 40g, Radix Rubiae 30g ~ 40g, Caulis Bambusae In Taenia 25g ~ 35g, Herba Agrimoniae 35g ~ 45g, Radix Angelicae Sinensis 20g ~ 30g, Radix Paeoniae Rubra 30g ~ 40g, Flos Chrysanthemi 35g ~ 45g, Rhizoma Curcumae 25g ~ 35g, Herba Selaginellae 30g ~ 40g, Radix Pseudostellariae 35g ~ 45g, Ramulus Uncariae Cum Uncis 30g ~ 40g, Rhizoma Dioscoreae 20g ~ 30g, Chimonanthusn itens Oliv. 25g ~ 35g, Folium et Caulis Indigoferae Tinctoriae 25g ~ 35g, Isodon ternifolius 30g ~ 40g, Herba Eleusines Indicae 25g ~ 35g, Conyza japonica 30g ~ 40g, Herba Hyperici Sampsonii 15g ~ 25g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Fructus Jujubae 20g ~ 30g and Semen Cuscutae 30g ~ 40g,

The preparation method of described Chinese medicine composition oral liquid is specially,

The first step, Rhizoma Belamcandae, Rhizoma Coptidis, Herba Houttuyniae, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Herba Agrimoniae, Flos Chrysanthemi, Chimonanthusn itens Oliv., Folium et Caulis Indigoferae Tinctoriae, Isodon ternifolius, Herba Eleusines Indicae, Conyza japonica and Herba Hyperici Sampsonii are pulverized respectively, be mixed in proportion, obtain mixture, add relative to mixture quality 7-9 water doubly, soak and distill 3-5 hour after 3-5 hour, collect volatile oil, medicinal residues are for subsequent use;

Second step, remaining components is pulverized respectively, put into extract continuously and fill with, add the medicinal residues that the first step obtains again, extracting in water 3-5 hour, the water yield added is 6-8 times of described Chinese medicine composition each crude drug quality sum, extracting solution filters, relative density 1.10-1.12 when being concentrated into 60 DEG C, static 24 hours, get relative density 1.04 when supernatant reclaims ethanol and is concentrated into 20 DEG C, leave standstill 48 hours, get supernatant to filter, filtrate adds volatile oil prepared by the first step, tween 80 and appropriate correctives, adjustment volume is to 1000ml, filter, subpackage, sterilizing, obtain described oral liquid.