CN103599359B - For preventing the immune formulation of infectious bronchitis of chicken - Google Patents
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Abstract
The invention provides a kind of immune formulation for preventing infectious bronchitis of chicken, its crude drug includes Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.This Traditional Chinese medicine immune preparation has significant effect in prevention infectious bronchitis of chicken, and has nontoxic, drug resistance, drug residue free advantage.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of immune formulation for preventing infectious bronchitis of chicken.
Background technology
Infectious bronchitis of chicken (InfectiousBronchitis, IB) it is by infectious bronchitis virus (InfectiousBronchitisVirus, IBV) the acute high degree in contact sexually transmitted disease of one caused, infected chicken is because of growth retardation, feed consumption increases, lays eggs and the decline of egg matter, death rate increase, causes tremendous economic to lose to poultry husbandry.In order to effectively prevent and control the generation of this disease, now many employing vaccine immunities and western medicine, because IBV strain has the feature of highly variable different and many serotype, and make immunity inoculation complicate, it is difficult to preventing and treating.At present, China mainly prevents and treats infectious bronchitis of chicken with Western medicine, but owing to Western medicine excretes mainly through by renal metabolism, and the kidney damage caused by this disease makes medicine put aside in a large number in vivo, the not only unsatisfactory curative effect to this disease, but also easily caused by drug intoxication.
Chinese medicine has distinctive feature in animal organism physiological function carrying out comprehensively regulating, improves body immunity, premunition and antiviral etc., can effectively prevention and control and this disease for the treatment of.Chinese veterinarian thinks that infectious bronchitis is mainly in pyretic toxicity, noxious dampness, epidemic disease poison and accumulates, and causes sputum to block trachea, causes cough with asthma, flows nose liquid, cough with asthma injures healthy energy, causes failure of the kidney in receiving QI, and Wei Yang does not fill, and dificiency in lower-JIAO is contained, suffer from a deficiency of the kidney and water liquid can not normally be evaporated, therefore coldness of the body with chills, feces is abnormal.
The dirty pathology and disease mechanism of the Clinical symptoms of infectious bronchitis of chicken and traditional Chinese veterinary medicine lung, spleen, kidney three is closely related, theoretical according to Chinese veterinarian, infectious bronchitis of chicken is that epidemic disease poison heresy violates lung, expectorant is turbid to be jammed, cause that impaired depurative descending of lung QI, qi stagnation hemagglutination, body fluid lose in caused by spreading, its disease basic at lung, Syndrome Differentiation of Traditional Chinese Medicine is in the majority with affection due to external wind and heat, minority is syndrome of superficies cold and interior heat, all belongs to heat and is defending point or simultaneous occurrence of syndromes of both QI and WEI systems.
Summary of the invention
The technical problem to be solved is to provide a kind of Traditional Chinese medicine immune preparation for preventing infectious bronchitis of chicken, and it has significant effect in prevention infectious bronchitis of chicken, and has nontoxic, drug resistance, drug residue free advantage.
For solving above-mentioned technical problem, the invention provides a kind of Traditional Chinese medicine immune preparation for preventing infectious bronchitis of chicken, its crude drug includes Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.
nullWherein，In described Traditional Chinese medicine immune preparation, the weight portion of each crude drug is respectively as follows: Herba Sarcandrae 25 weight portion～35 weight portion、Radix Scutellariae 45 weight portion～55 weight portion、Fructus Arctii 25 weight portion～35 weight portion、Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portion、Fructus Gardeniae 45 weight portion～55 weight portion、Radix Ophiopogonis 55 weight portion～65 weight portion、Rhizoma Polygonati 45 weight portion～55 weight portion、Radix Pseudostellariae 75 weight portion～85 weight portion、Caulis Polygoni Multiflori 35 weight portion～45 weight portion、Fructus Lycii 55 weight portion～65 weight portion、Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portion、Fructus Schisandrae Chinensis 25 weight portion～35 weight portion、Herba Senecionis Scandentis 20 weight portion～30 weight portion、Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portion、Lignum Sappan 20 weight portion～30 weight portion、Fructus Jujubae 35 weight portion～45 weight portion、Radix Sophorae Tonkinensis 25 weight portion～35 weight portion、Radix Adenophorae 45 weight portion～55 weight portion、Calyx Kaki 20 weight portion～30 weight portion、Fructus Crataegi 25 weight portion～35 weight portion、Semen Raphani 20 weight portion～30 weight portion、Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portion、Semen Euryales 35 weight portion～45 weight portion、Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portion、Herba Fici Simplicissimae 30 weight portion～40 weight portion and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portion.
nullWherein，The weight portion of each crude drug respectively Herba Sarcandrae 28 weight portion～32 weight portion in described Traditional Chinese medicine immune preparation、Radix Scutellariae 48 weight portion～52 weight portion、Fructus Arctii 28 weight portion～32 weight portion、Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portion、Fructus Gardeniae 48 weight portion～52 weight portion、Radix Ophiopogonis 58 weight portion～62 weight portion、Rhizoma Polygonati 48 weight portion～52 weight portion、Radix Pseudostellariae 78 weight portion～82 weight portion、Caulis Polygoni Multiflori 38 weight portion～42 weight portion、Fructus Lycii 58 weight portion～62 weight portion、Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portion、Fructus Schisandrae Chinensis 28 weight portion～32 weight portion、Herba Senecionis Scandentis 23 weight portion～27 weight portion、Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portion、Lignum Sappan 23 weight portion～27 weight portion、Fructus Jujubae 38 weight portion～42 weight portion、Radix Sophorae Tonkinensis 28 weight portion～32 weight portion、Radix Adenophorae 48 weight portion～52 weight portion、Calyx Kaki 23 weight portion～27 weight portion、Fructus Crataegi 28 weight portion～32 weight portion、Semen Raphani 23 weight portion～27 weight portion、Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portion、Semen Euryales 38 weight portion～42 weight portion、Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portion、Herba Fici Simplicissimae 33 weight portion～37 weight portion and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portion.
Wherein, the weight portion of each crude drug respectively Herba Sarcandrae 30 weight portion in described Traditional Chinese medicine immune preparation, Radix Scutellariae 50 weight portion, Fructus Arctii 30 weight portion, Pseudobulbus Cremastrae Seu Pleiones 40 weight portion, Fructus Gardeniae 50 weight portion, Radix Ophiopogonis 60 weight portion, Rhizoma Polygonati 50 weight portion, Radix Pseudostellariae 80 weight portion, Caulis Polygoni Multiflori 40 weight portion, Fructus Lycii 60 weight portion, Bulbus Fritillariae Thunbergii 25 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Herba Senecionis Scandentis 25 weight portion, Herb Gynostemmae Pentaphylli 50 weight portion, Lignum Sappan 25 weight portion, Fructus Jujubae 40 weight portion, Radix Sophorae Tonkinensis 30 weight portion, Radix Adenophorae 50 weight portion, Calyx Kaki 25 weight portion, Fructus Crataegi 30 weight portion, Semen Raphani 25 weight portion, Ramulus et Folium Bauhiniae Faberi 30 weight portion, Semen Euryales 40 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Herba Fici Simplicissimae 35 weight portion and Caulis et folium cryptotaeniae japonicae 25 weight portion.
The preparation method that present invention also offers above-mentioned Traditional Chinese medicine immune preparation, particularly as follows:
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, take mixture 100g and load in percolator, add the Chinese liquor 600g～800g of 50 DEG C～55 DEG C, soak 20 hours～30 hours when 25 DEG C～35 DEG C, regulate percolator valve, making Chinese liquor medicinal liquid slowly ooze, oozing speed is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentration, removes Chinese liquor, dry, pulverize, it is thus achieved that the first dried powder；
Second step, is mixed in proportion remaining components, takes 100g mixture, add the water of 500g～800g, boil 3～4 hours, filter, obtaining the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, it is thus achieved that the second filtrate, the first filtrate and the second filtrate are mixed, concentration, removes water, dry, pulverize, it is thus achieved that the second dried powder；
3rd step, mixes the first dried powder and the second dried powder, it is thus achieved that Traditional Chinese medicine immune preparation powder.
Present invention also offers a kind of feedstuff for preventing infectious bronchitis of chicken, its raw material includes Semen Maydis, bean cake, Sal, fish flour, bone meal, trace mineral supplement, amino acid additive, vitamine supplement and for preventing the Traditional Chinese medicine immune preparation powder feed additive of infectious bronchitis of chicken.
Wherein, in described feedstuff, the weight portion of each material composition respectively Semen Maydis 90 weight portion～110 weight portion, bean cake 30 weight portion～50 weight portion, Sal 2 weight portion～4 weight portion, fish flour 8 weight portion～12 weight portion, bone meal 3 weight portion～5 weight portion, trace mineral supplement 2 weight portion～4 weight portion, amino acid additive 2 weight portion～4 weight portion, vitamine supplement 2 weight portion～4 weight portion and Traditional Chinese medicine immune preparation powder feed additive 15 weight portion～20 weight portion.
Wherein, in described feedstuff, the weight portion of each material composition respectively Semen Maydis 100 weight portion, bean cake 40 weight portion, Sal 3 weight portion, fish flour 10 weight portion, bone meal 4 weight portion, trace mineral supplement 3 weight portion, amino acid additive 3 weight portion, vitamine supplement 3 weight portion and Traditional Chinese medicine immune preparation powder feed additive 18 weight portion.
The preparation method that present invention also offers above-mentioned feedstuff, particularly as follows:
The first step, prepares described Traditional Chinese medicine immune preparation powder feed additive according to the method described above；
Second step, puts in fodder mixing machine together with the described Traditional Chinese medicine immune preparation powder feed additive obtained with the first step by other raw material components in feedstuff, and continuous uniform is put in pulverizer and pulverized, it is thus achieved that feedstuff after stirring 1～3 hour.
Beneficial effects of the present invention:
Traditional Chinese medicine immune preparation provided by the invention has significant effect in prevention infectious bronchitis of chicken, and has nontoxic, drug resistance, drug residue free advantage.
Detailed description of the invention
Chinese veterinarian treats infectious bronchitis and adheres to eliminating evil principle big with righting two, the eliminating evil heresy being to dispel harmful cause of disease-epidemic disease poison, namely suppresses or eliminates virulence factor, getting rid of pathological product.Hold up the premunition being exactly based on enhancing body, improve immunologic function, righting is widely used in various infectious disease all the time, basic principle is yin nourishing Bao Jin, and medicinal herb components can directly be degraded the toxin of pathogen, moreover it is possible to the immunologic function of enhancing body, virus is suppressed by heat-clearing and toxic substances removing, be aided with removing heat-phlegm, antiasthmatic-antitussive reaches eliminating evil purpose, and the collaborative common enhancing human body immunity power of tonification class Chinese medicine, reaches the purpose of righting.
Theoretical according to traditional Chinese veterinary medicine, caused by invading in infectious bronchitis of chicken system epidemic disease poison, belong to epidemic febrile disease category, clinical most commonly seen with the syndrome in QI system marquis of accumulation of heat in the lung, accumulation of heat in the lung, department should be lost clearly, QI rising in reverse order expectorant is stopped up, therefore sees the diseases such as cough, asthma.Because its characteristic of disease belongs to heat, sick position at lung, control should heat-clearing and toxic substances removing, should lung relieving asthma, relieving cough and resolving phlegm.
Based on above-mentioned theory of Chinese medical science, the present invention proposes with invigorating the spleen and replenishing QI, and yin nourishing Bao Jin is main, be aided with heat-clearing and toxic substances removing, should lung relieving asthma, relieving cough and resolving phlegm, it is achieved the prevention to infectious bronchitis of chicken.
The invention provides a kind of Traditional Chinese medicine immune preparation for preventing infectious bronchitis of chicken, its crude drug includes Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.
Further, described Traditional Chinese medicine immune preparation is only made up of above-mentioned raw materials medicine.
nullFang Zhong，Herba Sarcandrae anti-inflammation，Containing isofraxidin、Fumaric acid、Succinic acid、Lignum-vitae base lignan，Energy metabolism can be improved，Broad-spectrum antiseptic，Virus replication，Immunologic function had dual regulation，Radix Scutellariae heat-clearing and toxic substances removing has releasing bronchospasm effect，Fructus Arctii preventing phlegm from forming and stopping coughing、Clearing throat，Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing，Dissipating phlegm and resolving masses，Fructus Gardeniae dispersing the stagnated live-QI to relieve the stagnation of QI、Clearing away heat-damp and promoting diuresis，Radix Ophiopogonis nourishing YIN and moistening the lung、Preventing phlegm from forming and stopping coughing，Rhizoma Polygonati、Radix Pseudostellariae、Saponin contained by Radix Et Caulis Acanthopanacis Senticosi、Polysaccharide、Flavonoid、Organic acid and vitamin isoreactivity composition，There is strongly invigorating primordial QI，Multiple arteries and veins takes off admittedly，Invigorating the spleen to benefit the lung，Promote the production of body fluid，Calm the nerves effect，Body's immunity and anti-stress ability can be significantly improved，There is antiviral activity，Caulis Polygoni Multiflori can promote hemopoietic function，There is tonic effect，Fructus Lycii nourishing YIN and moistening the lung cough-relieving，Bulbus Fritillariae Thunbergii nourishing the lung to arrest cough reduces phlegm，Fructus Schisandrae Chinensis relieving cough and asthma，Herba Senecionis Scandentis heat-clearing and toxic substances removing，Humoral immunization is had facilitation by Herb Gynostemmae Pentaphylli，Lignum Sappan blood circulation promoting and blood stasis dispelling，Fructus Jujubae air making-up and spleen enlivening、Nourishing blood to tranquillize the mind，Radix Sophorae Tonkinensis resolving toxin and disinhibiting the throat，Radix Adenophorae nourishing the lung to arrest cough，Nourishing the stomach to promote the production of body fluid，Calyx Kaki lowering the adverse flow of QI，Fructus Crataegi、Semen Raphani invigorating the stomach and promoting digestion，Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing，Dampness removing is antipruritic，Semen Euryales supplementing the kidney to control the nocturnal，Tonifying spleen and stopping diarrhea，Herba Fici Simplicissimae invigorating the spleen for eliminating dampness，Promoting the circulation of QI and reducing phlegm，Caulis et folium cryptotaeniae japonicae dispelling wind stopping cough，Eliminating damp, detoxifying.
Herba Sarcandrae: latin name SarcandraeHerba, slightly warm in nature, bitter in the mouth, pungent, there is anti-inflammation, dispelling wind and removing obstruction in the collateral, effect of blood circulation promoting and dispersing pathogen accumulation, cure mainly the cards such as pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.
Radix Scutellariae: latin name ScutellariaeRadix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have a heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, it is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria；Cough due to lung-heat, thirsty pharyngalgia, it may also be used for excessive fetal movement due to heat in pregnancy, pyretic toxicity pathogenic fire invades the card that the carbuncle sore poison of excessive skin swells.
Fructus Arctii: acrid in the mouth is bitter；Cold in nature, return lung, stomach warp, there is dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, lung qi dispersing sore-throat relieving dissipates swollen effect, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of；Wind heat or cough due to lung-heat, cough up phlegm not smooth；Laryngopharynx swelling and pain；Macule is not saturating；At the measles initial stage, rash goes out not smooth and rubella pruritus；Sore swollen toxin and mumps etc. are demonstrate,proved.
Pseudobulbus Cremastrae Seu Pleiones: sweet in the mouth, micro-pungent, cool in nature, to return liver, spleen channel, there is heat-clearing and toxic substances removing, effect of dissipating phlegm and resolving masses, for cards such as carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, snake bite and insect stings.
Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in epidemic febrile disease heat stagnation breast gastral cavity vexed uneasiness, bother not peaceful；Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx；Jaundice due to damp-heat；The symptoms such as the abdominal distention of qi depression to blood stasis.
Radix Ophiopogonis: latin name OphiopogonisRadix, sweet in the mouth, micro-hardship, cold nature, enter the heart, lung, stomach warp, there is nourishing YIN and moistening the lung, effect that preventing phlegm from forming and stopping coughing, heat clearing away are nourished heart, cure mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, dry mouth and throat caused by thermal burn stomach-Yin or deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dry wait card.
Rhizoma Polygonati: sweet in the mouth, the cards such as property is put down, and enters lung, spleen, kidney channel, has nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, and for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and enters spleen, lung meridian, has air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, energy strengthening the spleen gas, nourishing stomach-YIN, deficiency of the lung cough caused by dryness and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis for deficiency of vital energy Tianjin wound, energy supplementing QI for promoting the production of body fluid, controls deficiency of vital energy xeropulmonary cough, and the cardiopalmus sleeplessness of deficiency of both QI and YIN, hyperhidrosis etc. are demonstrate,proved.
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down；GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, and wind skin ulcer scabies etc. is demonstrate,proved.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in liver and kidney deficiency, the soreness of the waist and knees of asthenia of essence and blood, dizziness and tinnitus, seminal emission tinnitus, unconsciously sweat and tire；The sexual impotence of insufficiency of kidney-YANG, sterile；Deficiency of YIN-essence, deficiency of liver-blood eyes is dim-sighted and the card such as deficiency of YIN chronic cough.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, enter lung, heart channel, there is removing heat-phlegm, effect of powder detoxifcation, cure mainly the cards such as cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, cure mainly chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, the cards such as Tianjin wound is thirsty, deficient pulse of losing heart, and interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth, returns lung, Liver Channel, has effect of heat-clearing and toxic substances removing, improving eyesight dampness removing, having the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema, staphylococcus aureus, colon bacillus, dysentery bacterium are had antibacterial activity by Herba Senecionis Scandentis.
Herb Gynostemmae Pentaphylli: cold in nature, sweet in the mouth, returns lung, spleen, kidney channel, has QI invigorating, calm the nerves, effect of blood pressure lowering, and for deficiency of vital energy and physically weak, few gas is weak；Vexed insomnia；Hypertension, Light-headedness；Viral hepatitis；Digestive tract tumor；Chronic bronchitis, Herb Gynostemmae Pentaphylli rich in polysaccharide can improve serum hemolysis cellulose content, humoral immunization is had facilitation, Herb Gynostemmae Pentaphylli rich in total saponins can promote lymphocyte transformation, improve the activity of DNA polysaccharide, promote the synthesis of lymphocyte DNA.
Lignum Sappan: sweet in the mouth, one-tenth, property is put down, and GUIXIN, liver, spleen channel have blood circulation promoting and blood stasis dispelling, effect of reducing swelling and alleviating pain, cures mainly traumatic injury, muscle and tendon injury of fracturing, the cards such as stasis swells and ache, amenorrhea dysmenorrhea, postpartum stagnation, chest and abdomen twinge.
Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp, there is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood, have a headache and fever, sweating hot blast etc. is demonstrate,proved.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, enter the heart, lung, large intestine channel, there is resolving toxin and disinhibiting the throat, clearing away heat-damp and promoting diuresis, effect that parasite killing is anticancer, for laryngopharynx swelling and pain, swelling of the gum toothache, cough due to lung-heat, dysentery, jaundice, the swollen tinea alba of heat etc. is demonstrate,proved.
The cards such as Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, have nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, is mainly used in lung-dryness syndrome due to deficiency of YIN, dry cough few expectorant, chronic cough expectorant blood, the few tongue of deficiency of stomach-Yin, mouthfeel parched throat, constipation, red tongue.
Calyx Kaki: bitter in the mouth, flat, return stomach warp, there is effect of lowering the adverse flow of QI, cure mainly singultus；Eructation；Regurgitation etc. are demonstrate,proved.
Sour in the mouth, sweet, slightly warm in nature, to return spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi is the regular supplies for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion；Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. had obvious inhibitory action.
Semen Raphani: property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stop up cards such as breathing with cough.
Ramulus et Folium Bauhiniae Faberi: mildly bitter flavor, micro-acid, cool in nature, there is heat-clearing and toxic substances removing, effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis；The cards such as eczema, dermatitis, skin pruritus are controlled in external.
Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, the function of damp eliminating leukorrhagia stopping, cure mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, be with inferior card.
Radix Et Caulis Acanthopanacis Senticosi: latin name AcanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, demonstrate,prove for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity is soft, be slow in action, body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched etc..
Herba Fici Simplicissimae: sweet, tepor, there is invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cure mainly pulmonary tuberculosis cough, chronic bronchitis, rheumatic arthritis, lumbago and skelalgia, insufficiency of the spleen edema, the after being ill card such as night sweat.
Caulis et folium cryptotaeniae japonicae: acrid in the mouth is bitter；Property is put down, and has dispelling wind stopping cough；Eliminating damp, detoxifying；Effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, gonorrhea, hernia, acute toothache, the cards such as carbuncle furuncle swells, herpes zoster, skin pruritus.
nullIn described Traditional Chinese medicine immune preparation, the weight portion of each crude drug is respectively as follows: Herba Sarcandrae 25 weight portion～35 weight portion、Radix Scutellariae 45 weight portion～55 weight portion、Fructus Arctii 25 weight portion～35 weight portion、Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portion、Fructus Gardeniae 45 weight portion～55 weight portion、Radix Ophiopogonis 55 weight portion～65 weight portion、Rhizoma Polygonati 45 weight portion～55 weight portion、Radix Pseudostellariae 75 weight portion～85 weight portion、Caulis Polygoni Multiflori 35 weight portion～45 weight portion、Fructus Lycii 55 weight portion～65 weight portion、Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portion、Fructus Schisandrae Chinensis 25 weight portion～35 weight portion、Herba Senecionis Scandentis 20 weight portion～30 weight portion、Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portion、Lignum Sappan 20 weight portion～30 weight portion、Fructus Jujubae 35 weight portion～45 weight portion、Radix Sophorae Tonkinensis 25 weight portion～35 weight portion、Radix Adenophorae 45 weight portion～55 weight portion、Calyx Kaki 20 weight portion～30 weight portion、Fructus Crataegi 25 weight portion～35 weight portion、Semen Raphani 20 weight portion～30 weight portion、Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portion、Semen Euryales 35 weight portion～45 weight portion、Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portion、Herba Fici Simplicissimae 30 weight portion～40 weight portion and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portion.
nullIt is preferred that，The weight portion of each crude drug respectively Herba Sarcandrae 28 weight portion～32 weight portion in described Traditional Chinese medicine immune preparation、Radix Scutellariae 48 weight portion～52 weight portion、Fructus Arctii 28 weight portion～32 weight portion、Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portion、Fructus Gardeniae 48 weight portion～52 weight portion、Radix Ophiopogonis 58 weight portion～62 weight portion、Rhizoma Polygonati 48 weight portion～52 weight portion、Radix Pseudostellariae 78 weight portion～82 weight portion、Caulis Polygoni Multiflori 38 weight portion～42 weight portion、Fructus Lycii 58 weight portion～62 weight portion、Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portion、Fructus Schisandrae Chinensis 28 weight portion～32 weight portion、Herba Senecionis Scandentis 23 weight portion～27 weight portion、Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portion、Lignum Sappan 23 weight portion～27 weight portion、Fructus Jujubae 38 weight portion～42 weight portion、Radix Sophorae Tonkinensis 28 weight portion～32 weight portion、Radix Adenophorae 48 weight portion～52 weight portion、Calyx Kaki 23 weight portion～27 weight portion、Fructus Crataegi 28 weight portion～32 weight portion、Semen Raphani 23 weight portion～27 weight portion、Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portion、Semen Euryales 38 weight portion～42 weight portion、Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portion、Herba Fici Simplicissimae 33 weight portion～37 weight portion and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portion.
Further preferred, the weight portion of each crude drug respectively Herba Sarcandrae 30 weight portion in described Traditional Chinese medicine immune preparation, Radix Scutellariae 50 weight portion, Fructus Arctii 30 weight portion, Pseudobulbus Cremastrae Seu Pleiones 40 weight portion, Fructus Gardeniae 50 weight portion, Radix Ophiopogonis 60 weight portion, Rhizoma Polygonati 50 weight portion, Radix Pseudostellariae 80 weight portion, Caulis Polygoni Multiflori 40 weight portion, Fructus Lycii 60 weight portion, Bulbus Fritillariae Thunbergii 25 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Herba Senecionis Scandentis 25 weight portion, Herb Gynostemmae Pentaphylli 50 weight portion, Lignum Sappan 25 weight portion, Fructus Jujubae 40 weight portion, Radix Sophorae Tonkinensis 30 weight portion, Radix Adenophorae 50 weight portion, Calyx Kaki 25 weight portion, Fructus Crataegi 30 weight portion, Semen Raphani 25 weight portion, Ramulus et Folium Bauhiniae Faberi 30 weight portion, Semen Euryales 40 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Herba Fici Simplicissimae 35 weight portion and Caulis et folium cryptotaeniae japonicae 25 weight portion.
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, take mixture 100g and load in percolator, add the Chinese liquor 600g～800g of 50 DEG C～55 DEG C, soak 20 hours～30 hours when 25 DEG C～35 DEG C, regulate percolator valve, making Chinese liquor medicinal liquid slowly ooze, oozing speed is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentration, removes Chinese liquor, dry, pulverize, it is thus achieved that the first dried powder；
Second step, is mixed in proportion remaining components, takes 100g mixture, add the water of 500g～800g, boil 3～4 hours, filter, obtaining the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, it is thus achieved that the second filtrate, the first filtrate and the second filtrate are mixed, concentration, removes water, dry, pulverize, it is thus achieved that the second dried powder；
3rd step, mixes the first dried powder and the second dried powder, it is thus achieved that Traditional Chinese medicine immune preparation powder.
Traditional Chinese medicine immune preparation provided by the invention can be admixed in feedstuff and take for chicken, or is dissolved in water and gavages to chicken.
Present invention also offers a kind of feedstuff for preventing infectious bronchitis of chicken, its raw material includes Semen Maydis, bean cake, Sal, fish flour, bone meal, trace mineral supplement, amino acid additive, vitamine supplement and for preventing the Traditional Chinese medicine immune preparation powder feed additive of infectious bronchitis of chicken.
Further, described feedstuff is only made up of above-mentioned raw materials.
Wherein, in described feedstuff, the weight portion of each material composition respectively Semen Maydis 90 weight portion～110 weight portion, bean cake 30 weight portion～50 weight portion, Sal 2 weight portion～4 weight portion, fish flour 8 weight portion～12 weight portion, bone meal 3 weight portion～5 weight portion, trace mineral supplement 2 weight portion～4 weight portion, amino acid additive 2 weight portion～4 weight portion, vitamine supplement 2 weight portion～4 weight portion and Traditional Chinese medicine immune preparation powder feed additive 15 weight portion～20 weight portion.
It is preferred that, in described feedstuff, the weight portion of each material composition respectively Semen Maydis 100 weight portion, bean cake 40 weight portion, Sal 3 weight portion, fish flour 10 weight portion, bone meal 4 weight portion, trace mineral supplement 3 weight portion, amino acid additive 3 weight portion, vitamine supplement 3 weight portion and Traditional Chinese medicine immune preparation powder feed additive 18 weight portion.
Trace mineral supplement can be the trace mineral supplement of various routine, simple acylate can be used, such as ferric citrate, trace element and amino-acid chelate can also be used, such as aminoacid ferrum, the trace element added mainly has ferrum, zinc, copper, manganese, iodine, cobalt, selenium, molybdenum, it is possible to use composite trace element premix, Great Britain and America's that profit keeping normal life activities thing science and technology limited Company as excellent in Beijing provides.
Amino acid additive includes the various conventional amino acid such as serine, glutamic acid, glycine, isoleucine, leucine, alanine, proline, it would however also be possible to employ aminoacid premix material, the Aminoacids complex powder that as above sea cowry energy Chemical Co., Ltd. produces.
Vitamine supplement includes the various conventional vitamin such as riboflavin, vitamin C, vitamin E, vitamin A, vitamin B, it would however also be possible to employ vitamin premix, such as the excellent dimension element that Beijing You Libao Bioisystech Co., Ltd produces.
The preparation method that present invention also offers above-mentioned feedstuff, particularly as follows:
The first step, prepares described Traditional Chinese medicine immune preparation powder feed additive according to the method described above；
Second step, puts in fodder mixing machine together with the described Traditional Chinese medicine immune preparation powder feed additive obtained with the first step by other raw material components in feedstuff, and continuous uniform is put in pulverizer and pulverized, it is thus achieved that feedstuff after stirring 1～3 hour.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 Traditional Chinese medicine immune preparation 1
nullBy 60g Radix Ophiopogonis、Rhizoma Polygonati 50g、Radix Pseudostellariae 80g、Caulis Polygoni Multiflori 40g、Fructus Lycii 60g、Herb Gynostemmae Pentaphylli 50g、Fructus Jujubae 40g、Radix Adenophorae 50g、Semen Euryales 40g and Radix Et Caulis Acanthopanacis Senticosi 35g is mixed in proportion，Take mixture 100g to load in percolator，Add the Chinese liquor 700g of 50 DEG C，Soak 25 hours when 30 DEG C，Regulate percolator valve，Chinese liquor medicinal liquid is made slowly to ooze，Oozing speed is 3mL per minute，Collect drip，Obtain the percolate of 800mL，Concentration，Remove Chinese liquor，Dry，Pulverize，Obtain the first dried powder，By Herba Sarcandrae 30g、Radix Scutellariae 50g、Fructus Arctii 30g、Pseudobulbus Cremastrae Seu Pleiones 40g、Fructus Gardeniae 50g、Bulbus Fritillariae Thunbergii 25g、Fructus Schisandrae Chinensis 30g、Herba Senecionis Scandentis 25g、Lignum Sappan 25g、Radix Sophorae Tonkinensis 30g、Calyx Kaki 25g、Fructus Crataegi 30g、Semen Raphani 25g、Ramulus et Folium Bauhiniae Faberi 30g、Herba Fici Simplicissimae 35g and Caulis et folium cryptotaeniae japonicae 25g mixing，Take 100g mixture，Add the water of 600g，Boil 4 hours，Filter，Obtain the first filtrate，Filtering residue adds the water of 300g again，Again boil 2 hours，Filter，Obtain the second filtrate，First filtrate and the second filtrate are mixed，Concentration，Remove water，Dry，Pulverize，Obtain the second dried powder，First dried powder and the second dried powder are mixed，Obtain Traditional Chinese medicine immune preparation 1.
Embodiment 2 Traditional Chinese medicine immune preparation 2
nullBy 58g Radix Ophiopogonis、Rhizoma Polygonati 48g、Radix Pseudostellariae 78g、Caulis Polygoni Multiflori 38g、Fructus Lycii 58g、Herb Gynostemmae Pentaphylli 48g、Fructus Jujubae 38g、Radix Adenophorae 48g、Semen Euryales 38g and Radix Et Caulis Acanthopanacis Senticosi 33g is mixed in proportion，Take mixture 100g to load in percolator，Add the Chinese liquor 700g of 50 DEG C，Soak 25 hours when 30 DEG C，Regulate percolator valve，Chinese liquor medicinal liquid is made slowly to ooze，Oozing speed is 3mL per minute，Collect drip，Obtain the percolate of 800mL，Concentration，Remove Chinese liquor，Dry，Pulverize，Obtain the first dried powder，By Herba Sarcandrae 28g、Radix Scutellariae 48g、Fructus Arctii 28g、Pseudobulbus Cremastrae Seu Pleiones 38g、Fructus Gardeniae 48g、Bulbus Fritillariae Thunbergii 23g、Fructus Schisandrae Chinensis 28g、Herba Senecionis Scandentis 23g、Lignum Sappan 23g、Radix Sophorae Tonkinensis 28g、Calyx Kaki 23g、Fructus Crataegi 28g、Semen Raphani 23g、Ramulus et Folium Bauhiniae Faberi 28g、Herba Fici Simplicissimae 33g and Caulis et folium cryptotaeniae japonicae 23g mixing，Take 100g mixture，Add the water of 600g，Boil 4 hours，Filter，Obtain the first filtrate，Filtering residue adds the water of 300g again，Again boil 2 hours，Filter，Obtain the second filtrate，First filtrate and the second filtrate are mixed，Concentration，Remove water，Dry，Pulverize，Obtain the second dried powder，First dried powder and the second dried powder are mixed，Obtain Traditional Chinese medicine immune preparation 2.
Embodiment 3 Traditional Chinese medicine immune preparation 3
nullBy 62g Radix Ophiopogonis、Rhizoma Polygonati 52g、Radix Pseudostellariae 82g、Caulis Polygoni Multiflori 42g、Fructus Lycii 62g、Herb Gynostemmae Pentaphylli 52g、Fructus Jujubae 42g、Radix Adenophorae 52g、Semen Euryales 42g and Radix Et Caulis Acanthopanacis Senticosi 37g is mixed in proportion，Take mixture 100g to load in percolator，Add the Chinese liquor 700g of 50 DEG C，Soak 25 hours when 30 DEG C，Regulate percolator valve，Chinese liquor medicinal liquid is made slowly to ooze，Oozing speed is 3mL per minute，Collect drip，Obtain the percolate of 800mL，Concentration，Remove Chinese liquor，Dry，Pulverize，Obtain the first dried powder，By Herba Sarcandrae 32g、Radix Scutellariae 52g、Fructus Arctii 32g、Pseudobulbus Cremastrae Seu Pleiones 42g、Fructus Gardeniae 52g、Bulbus Fritillariae Thunbergii 27g、Fructus Schisandrae Chinensis 32g、Herba Senecionis Scandentis 27g、Lignum Sappan 27g、Radix Sophorae Tonkinensis 32g、Calyx Kaki 27g、Fructus Crataegi 32g、Semen Raphani 27g、Ramulus et Folium Bauhiniae Faberi 32g、Herba Fici Simplicissimae 37g and Caulis et folium cryptotaeniae japonicae 27g mixing，Take 100g mixture，Add the water of 600g，Boil 4 hours，Filter，Obtain the first filtrate，Filtering residue adds the water of 300g again，Again boil 2 hours，Filter，Obtain the second filtrate，First filtrate and the second filtrate are mixed，Concentration，Remove water，Dry，Pulverize，Obtain the second dried powder，First dried powder and the second dried powder are mixed，Obtain Traditional Chinese medicine immune preparation 3.
Embodiment 4 toxicological experiment
Acute toxicity testing
Select Kunming mouse 20, female half and half, body weight (20+2) g, thered is provided by Qingdao City's Experimental Animal Center, Traditional Chinese medicine immune preparation prepared by embodiment 1 is dissolved in water, it is thus achieved that crude drug concentration is the solution of 1g/ml, gavages mice, through preliminary experiment, fail to detect the LD of oral administration50, therefore survey its maximum tolerated dose, administration volume with 1.4ml/10g body weight, gavage 2 times/d, interval 6h, to observation post administration 7d, record animal dead and toxicity symptom, when experiment terminates, all animals is processed, dissect, the each main organs lesion tissue situation of perusal, after gavaging 140g crude drug/kg for 2 times, animal activity, feed water inlet does not show any abnormalities, observe 7d animal dead, gross necropsy has no the obvious abnormal of main organs tissue, therefore, the maximum dosage-feeding of Chinese medicine granules is > 140g crude drug/kg, this dosage is equivalent to 70 times of maximum oral dose 2g crude drug/kg clinical adult's (by 60kg) every day.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, thered is provided by Qingdao City's Experimental Animal Center, it is randomly divided into 2 groups, blank group and Chinese drug-treated group, often group 20, blank group gives distilled water, Traditional Chinese medicine immune preparation prepared by embodiment 1 is dissolved in water, obtaining crude drug concentration is the solution of 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, during being administered front and administration, every day observes rat general state, sign, food ration, drinking-water and feces situation.During administration 90d after last is administered 24h, each group extracts 6, male and female half and half；During 180d after last administration 24h, each group extracts 6, male and female half and half；After drug withdrawal, 30d respectively organizes extraction 6, male and female half and half, anaesthetize with urethane, blood is taken from abdominal aortic, each group is all killed and takes animal, checks hematology and blood parameters, after taking blood, amass wealth by heavy taxation at once core, liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, the internal organs such as prostate are weighed, according to weight calculator official's weight coefficient and make pathological examination.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, animal has no dead, naked eyes have no obvious pathological changes, each group rat peripheral hemogram checking is all in normal range, and physiochemical indice is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is not significantly different from compared with blank group.
Embodiment 5 feedstuff 1
Are put in fodder mixing machine together with the Traditional Chinese medicine immune preparation 1.8kg that Semen Maydis 10kg, bean cake 4kg, Sal 0.3kg, fish flour 0.1kg, bone meal 0.4kg, your (Beijing excellent profit keeping normal life activities thing science and technology limited Company provide) 0.3kg of trace mineral supplement Great Britain and America, amino acid additive Aminoacids complex powder (upper sea cowry energy Chemical Co., Ltd. produce) 0.3kg, excellent dimension element (production of Beijing You Libao Bioisystech Co., Ltd) 0.3kg of vitamine supplement are prepared with embodiment 1, after continuous uniform stirs 3 hours, put in pulverizer and pulverize, it is thus achieved that feedstuff 1.
Comparative example 1 feedstuff 2
Semen Maydis 10kg, bean cake 4kg, Sal 0.3kg, fish flour 0.1kg, bone meal 0.4kg, trace mineral supplement Great Britain and America that (Beijing excellent profit keeping normal life activities thing science and technology limited Company provides) 0.3kg, amino acid additive Aminoacids complex powder (above sea cowry energy Chemical Co., Ltd. produces) 0.3kg, excellent element (production of Beijing You Libao Bioisystech Co., Ltd) 0.3kg that ties up of vitamine supplement are put in fodder mixing machine together, after continuous uniform stirs 3 hours, put in pulverizer and pulverize, it is thus achieved that feedstuff 2.
Embodiment 6 zoopery
Laboratory animal
Select 7 age in days health SPF chicken 400, Qingdao Nanjing brocade laboratory animal company limited provide, prevent epidemic without infectious bronchitis vaccine, be randomly divided into 4 groups, often group 100.
Normal healthy controls group: not counteracting toxic substances, does not feed any medicine, isolated rearing, feeding corn feed.
Counteracting toxic substances matched group: after counteracting toxic substances, does not feed any medicine, isolated rearing, feeding corn feed.
Prevent 1 group: counteracting toxic substances starts the feedstuff 1 of feeding embodiment 5 preparation for first 3 days.
Prevent 2 groups: counteracting toxic substances starts the feedstuff 2 of feeding comparative example 1 preparation for first 3 days.
Experimental drug
The feedstuff 1 of embodiment 5 preparation and the feedstuff 2 of comparative example 1 preparation.
Infectious bronchitis virus
Counteracting toxic substances IBVM41 virulent strain, is provided by China Veterinary Drugs Supervisory Inst., after being diluted by virus 1:10 during use through trachea inoculation test chicken 0.2ml/ only.
Syndrome Scale and curative effect judging standard
Through trial test determine IBV-M41 strain kind poison infective dose be that every plumage 0.2mL carries out collunarium inoculation.When counteracting toxic substances matched group majority chicken falls ill, each group of chicken is carried out clinical symptoms and scores, and test chicken is cutd open inspection, cut open inspection symptom score, calculate each group of result of scoring, conclude according to curative effect judging standard.Clinical symptoms classification, cut open inspection Syndrome Scale and curative effect determinate standard specific as follows:
Clinical symptoms classification
One-level (0 point): the chicken mental status is good, diet is intended to, activity is all normal.
Two grades (1 point): coughing in discontinuity, accidental nasal cavity has mucus, gets rid of head, food effect is little, and walking is normal.
Three grades (2 points): dyspnea, trachea has rale, and spirit is depressed, and feather is inverse vertical, peels off slow-witted vertical, and appetite declines or do not eat.
Level Four (3 points): dyspnea, death by suffocation.
Cut open inspection Syndrome Scale
One-level (0 point): without obvious pathological change.
Two grades (1 point): nasal cavity has mucus secretions, trachea and have thin mucus secretions in bronchus.The micro-muddiness of air bag.
Three grades (2 points): having the secretions of more thickness in trachea hypomere and bronchus, have no hemorrhage, air bag thickens.
Level Four (3 points): have the cheesy exudate of yellow in trachea hypomere and bronchus.Some trachea hypomeres and bronchus place have ring-type hemorrhage.Air bag thickens.
Curative effect determinate standard
Effective: to refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, and the morbidity main clinic symptoms of chicken, pathological change are obviously improved, i.e. 60% < therapeutic index < 100%.
Effective: to refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, and the morbidity main clinic symptoms of chicken, pathological change make moderate progress, i.e. 30% < therapeutic index < 60%.
Invalid: to refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, and the morbidity main clinic symptoms of chicken, pathological change are not improved or add severe one to some extent, i.e. therapeutic index < 30%.
Note: therapeutic index=(counteracting toxic substances matched group score-prevention group score) ÷ counteracting toxic substances matched group scores × 100%.
Data process&analysis
Each group data are used that mean soil standard deviationRepresenting, each group mean does test of normality and repeated measure homogeneity test of variance, with relatively young inspection between one factor analysis of variance group), P < 0.05 is notable for difference, and P < 0.01 is difference highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Result
There is significantly cough in counteracting toxic substances matched group major part chicken after counteracting toxic substances 48h, and the symptom such as rale, dyspnea occurs in part chicken, and sick chicken spirit is depressed, poor appetite, dead chicken is cutd open inspection, occurs that infectious bronchitis of chicken typical pathologic changes, counteracting toxic substances success is described.
Traditional Chinese medicine immune preparation of the present invention to the preventive effect of infectious bronchitis of chicken in Table 1.
Table 1 Traditional Chinese medicine immune preparation preventive effect to infectious bronchitis of chicken
As it can be seen from table 1 adopt the prevention group sickness rate of Traditional Chinese medicine immune preparation of the present invention to be significantly less than counteracting toxic substances matched group and the prevention group without Traditional Chinese medicine immune preparation of the present invention, illustrate that the preventive effect of this Traditional Chinese medicine immune preparation is notable.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement and/or the new method that limit other forms.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.
Claims (5)
1. the Traditional Chinese medicine immune preparation being used for preventing infectious bronchitis of chicken, it is characterised in that: crude drug is made up of Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae；
nullThe weight portion of each crude drug respectively Herba Sarcandrae 25 weight portion～35 weight portion in described Traditional Chinese medicine immune preparation、Radix Scutellariae 45 weight portion～55 weight portion、Fructus Arctii 25 weight portion～35 weight portion、Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portion、Fructus Gardeniae 45 weight portion～55 weight portion、Radix Ophiopogonis 55 weight portion～65 weight portion、Rhizoma Polygonati 45 weight portion～55 weight portion、Radix Pseudostellariae 75 weight portion～85 weight portion、Caulis Polygoni Multiflori 35 weight portion～45 weight portion、Fructus Lycii 55 weight portion～65 weight portion、Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portion、Fructus Schisandrae Chinensis 25 weight portion～35 weight portion、Herba Senecionis Scandentis 20 weight portion～30 weight portion、Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portion、Lignum Sappan 20 weight portion～30 weight portion、Fructus Jujubae 35 weight portion～45 weight portion、Radix Sophorae Tonkinensis 25 weight portion～35 weight portion、Radix Adenophorae 45 weight portion～55 weight portion、Calyx Kaki 20 weight portion～30 weight portion、Fructus Crataegi 25 weight portion～35 weight portion、Semen Raphani 20 weight portion～30 weight portion、Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portion、Semen Euryales 35 weight portion～45 weight portion、Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portion、Herba Fici Simplicissimae 30 weight portion～40 weight portion and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portion.
null2. Traditional Chinese medicine immune preparation as claimed in claim 1，It is characterized in that: the weight portion of each crude drug respectively Herba Sarcandrae 28 weight portion～32 weight portion in described Traditional Chinese medicine immune preparation、Radix Scutellariae 48 weight portion～52 weight portion、Fructus Arctii 28 weight portion～32 weight portion、Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portion、Fructus Gardeniae 48 weight portion～52 weight portion、Radix Ophiopogonis 58 weight portion～62 weight portion、Rhizoma Polygonati 48 weight portion～52 weight portion、Radix Pseudostellariae 78 weight portion～82 weight portion、Caulis Polygoni Multiflori 38 weight portion～42 weight portion、Fructus Lycii 58 weight portion～62 weight portion、Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portion、Fructus Schisandrae Chinensis 28 weight portion～32 weight portion、Herba Senecionis Scandentis 23 weight portion～27 weight portion、Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portion、Lignum Sappan 23 weight portion～27 weight portion、Fructus Jujubae 38 weight portion～42 weight portion、Radix Sophorae Tonkinensis 28 weight portion～32 weight portion、Radix Adenophorae 48 weight portion～52 weight portion、Calyx Kaki 23 weight portion～27 weight portion、Fructus Crataegi 28 weight portion～32 weight portion、Semen Raphani 23 weight portion～27 weight portion、Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portion、Semen Euryales 38 weight portion～42 weight portion、Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portion、Herba Fici Simplicissimae 33 weight portion～37 weight portion and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portion.
null3. Traditional Chinese medicine immune preparation as claimed in claim 1 or 2，It is characterized in that: the weight portion of each crude drug respectively Herba Sarcandrae 30 weight portion in described Traditional Chinese medicine immune preparation、Radix Scutellariae 50 weight portion、Fructus Arctii 30 weight portion、Pseudobulbus Cremastrae Seu Pleiones 40 weight portion、Fructus Gardeniae 50 weight portion、Radix Ophiopogonis 60 weight portion、Rhizoma Polygonati 50 weight portion、Radix Pseudostellariae 80 weight portion、Caulis Polygoni Multiflori 40 weight portion、Fructus Lycii 60 weight portion、Bulbus Fritillariae Thunbergii 25 weight portion、Fructus Schisandrae Chinensis 30 weight portion、Herba Senecionis Scandentis 25 weight portion、Herb Gynostemmae Pentaphylli 50 weight portion、Lignum Sappan 25 weight portion、Fructus Jujubae 40 weight portion、Radix Sophorae Tonkinensis 30 weight portion、Radix Adenophorae 50 weight portion、Calyx Kaki 25 weight portion、Fructus Crataegi 30 weight portion、Semen Raphani 25 weight portion、Ramulus et Folium Bauhiniae Faberi 30 weight portion、Semen Euryales 40 weight portion、Radix Et Caulis Acanthopanacis Senticosi 35 weight portion、Herba Fici Simplicissimae 35 weight portion and Caulis et folium cryptotaeniae japonicae 25 weight portion.
4. the preparation method of Traditional Chinese medicine immune preparation described in claim 1 or 2, it is characterised in that including:
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, take mixture 100g and load in percolator, add the Chinese liquor 600g～800g of 50 DEG C～55 DEG C, soak 20 hours～30 hours when 25 DEG C～35 DEG C, regulate percolator valve, making Chinese liquor medicinal liquid slowly ooze, oozing speed is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentration, removes Chinese liquor, dry, pulverize, it is thus achieved that the first dried powder；
Second step, is mixed in proportion remaining components, takes 100g mixture, add the water of 500g～800g, boil 3～4 hours, filter, obtaining the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, it is thus achieved that the second filtrate, the first filtrate and the second filtrate are mixed, concentration, removes water, dry, pulverize, it is thus achieved that the second dried powder；
3rd step, mixes the first dried powder and the second dried powder, it is thus achieved that Traditional Chinese medicine immune preparation.
5. the Traditional Chinese medicine immune preparation powder being used for preventing infectious bronchitis of chicken, it is characterised in that: crude drug is made up of Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae；
nullThe weight portion of each crude drug respectively Herba Sarcandrae 25 weight portion～35 weight portion in described Traditional Chinese medicine immune preparation powder、Radix Scutellariae 45 weight portion～55 weight portion、Fructus Arctii 25 weight portion～35 weight portion、Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portion、Fructus Gardeniae 45 weight portion～55 weight portion、Radix Ophiopogonis 55 weight portion～65 weight portion、Rhizoma Polygonati 45 weight portion～55 weight portion、Radix Pseudostellariae 75 weight portion～85 weight portion、Caulis Polygoni Multiflori 35 weight portion～45 weight portion、Fructus Lycii 55 weight portion～65 weight portion、Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portion、Fructus Schisandrae Chinensis 25 weight portion～35 weight portion、Herba Senecionis Scandentis 20 weight portion～30 weight portion、Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portion、Lignum Sappan 20 weight portion～30 weight portion、Fructus Jujubae 35 weight portion～45 weight portion、Radix Sophorae Tonkinensis 25 weight portion～35 weight portion、Radix Adenophorae 45 weight portion～55 weight portion、Calyx Kaki 20 weight portion～30 weight portion、Fructus Crataegi 25 weight portion～35 weight portion、Semen Raphani 20 weight portion～30 weight portion、Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portion、Semen Euryales 35 weight portion～45 weight portion、Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portion、Herba Fici Simplicissimae 30 weight portion～40 weight portion and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portion；
The preparation method of described Traditional Chinese medicine immune preparation powder specifically,
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, take mixture 100g and load in percolator, add the Chinese liquor 600g～800g of 50 DEG C～55 DEG C, soak 20 hours～30 hours when 25 DEG C～35 DEG C, regulate percolator valve, making Chinese liquor medicinal liquid slowly ooze, oozing speed is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentration, removes Chinese liquor, dry, pulverize, it is thus achieved that the first dried powder；
Second step, is mixed in proportion remaining components, takes 100g mixture, add the water of 500g～800g, boil 3～4 hours, filter, obtaining the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, it is thus achieved that the second filtrate, the first filtrate and the second filtrate are mixed, concentration, removes water, dry, pulverize, it is thus achieved that the second dried powder；
3rd step, mixes the first dried powder and the second dried powder, it is thus achieved that Traditional Chinese medicine immune preparation powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicament for preventing and controlling infectious bronchitis |
| CN101524479A (en) * | 2009-04-15 | 2009-09-09 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for curing avian infectious bronchitis |
| CN101647968A (en) * | 2009-08-31 | 2010-02-17 | 李敬云 | Traditional Chinese medicine composition for treating chicken infectious bronchitis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicament for preventing and controlling infectious bronchitis |
| CN101524479A (en) * | 2009-04-15 | 2009-09-09 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for curing avian infectious bronchitis |
| CN101647968A (en) * | 2009-08-31 | 2010-02-17 | 李敬云 | Traditional Chinese medicine composition for treating chicken infectious bronchitis |
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