CN103599359A - Immune preparation for preventing infectious bronchitis of chicken - Google Patents
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Abstract
The invention provides an immune preparation for preventing the infectious bronchitis of chicken. Raw drugs of the immune preparation comprise Glabrous Sarcandra Herb, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Polygonatum sibiricum, Radix Pseudostellariae, Caulis Polygoni Multiflori, wolfberry fruit, Fritillaria thunbergii Miq., Chinese magnoliavine, Climbing Groundsel Herb, Gynostemma pentaphylla, Sappanwood, Chinese date, Vietnamese Sophora Root, Adenophora stricta, Prsimmon Calyx, hawthorn fruit, radish seed, Euphorbia hirta, Semen Euryales, Manyprickle Acathopanax Root, Radix Fici Simplicissimae and Cryptotaenia japonica Hassk.. The traditional Chinese medicinal immune preparation has a substantial effect on the prevention of the infectious bronchitis of chicken, and has the advantages of non-toxicity, drug resistance and no drug residual.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of for preventing the immune formulation of infectious bronchitis of chicken.
Background technology
Infectious bronchitis of chicken (Infectious Bronchitis, IB) be by infectious bronchitis virus (Infectious Bronchitis Virus, IBV) a kind of acute height contagious disease causing, infected chicken is because of growth retardation, feed consumption increases, lays eggs and egg matter declines, death rate increases, and to poultry husbandry, causes tremendous economic loss.In order effectively to prevent and control the generation of this disease, existing vaccine immunity and the western medicines of adopting, because IBV strain has the feature of highly easily variation and many serotypes, and make immunity inoculation complicated more, are difficult to control.At present, China mainly prevents and treats infectious bronchitis of chicken with Western medicine, but because Western medicine mainly excretes via renal metabolism, and the kidney damage being caused by this disease is put aside medicine in vivo in a large number, the unsatisfactory curative effect sick to this not only, but also easily produce a toxic reaction to a drug.
Chinese medicine has distinctive feature at aspects such as animal organism physiological function being carried out to comprehensively regulating, raising body immunity, premunition and antiviral, effectively prevention and control and this disease for the treatment of.Chinese veterinarian thinks that infectious bronchitis is mainly to accumulate in pyretic toxicity, noxious dampness, epidemic disease poison, causes that sputum blocks trachea, causes cough with asthma, stream nose liquid, cough with asthma injures healthy energy, causes failure of the kidney in receiving QI, and Wei Yang does not fill, and on dificiency in lower-JIAO, contains, suffer from a deficiency of the kidney and can not normally evaporate water liquid, therefore coldness of the body with chills, feces is abnormal.
The dirty pathology and disease mechanism of the Clinical symptoms of infectious bronchitis of chicken and traditional Chinese veterinary medicine lung, spleen, kidney three is closely related, theoretical according to Chinese veterinarian, infectious bronchitis of chicken is the evil lung of violating of epidemic disease poison, expectorant is turbid to be jammed, cause impaired depurative descending of lung QI, qi stagnation hemagglutination, body fluid to lose due to the spreading, its disease at all at lung, Syndrome Differentiation of Traditional Chinese Medicine is in the majority with affection due to external wind and heat, minority is syndrome of superficies cold and interior heat, all belongs to heat and is defending minute or simultaneous occurrence of syndromes of both QI and WEI systems.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing the Chinese medicine immune formulation of infectious bronchitis of chicken, and it has significant effect in prevention aspect infectious bronchitis of chicken, and have nontoxic, the advantage of drug resistance, drug residue free.
For solving the problems of the technologies described above, the invention provides a kind ofly for preventing the Chinese medicine immune formulation of infectious bronchitis of chicken, its crude drug comprises Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.
Wherein, in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively: Herba Sarcandrae 25 weight portion～35 weight portions, Radix Scutellariae 45 weight portion～55 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portions, Fructus Gardeniae 45 weight portion～55 weight portions, Radix Ophiopogonis 55 weight portion～65 weight portion, Rhizoma Polygonati 45 weight portion～55 weight portions, Radix Pseudostellariae 75 weight portion～85 weight portions, Caulis Polygoni Multiflori 35 weight portion～45 weight portions, Fructus Lycii 55 weight portion～65 weight portions, Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portions, Fructus Schisandrae Chinensis 25 weight portion～35 weight portions, Herba Senecionis Scandentis 20 weight portion～30 weight portions, Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portions, Lignum Sappan 20 weight portion～30 weight portions, Fructus Jujubae 35 weight portion～45 weight portions, Radix Sophorae Tonkinensis 25 weight portion～35 weight portions, Radix Adenophorae 45 weight portion～55 weight portions, Calyx Kaki 20 weight portion～30 weight portions, Fructus Crataegi 25 weight portion～35 weight portions, Semen Raphani 20 weight portion～30 weight portions, Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portions, Semen Euryales 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portions, Herba Fici Simplicissimae 30 weight portion～40 weight portions and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portions.
Wherein, in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 28 weight portion～32 weight portions, Radix Scutellariae 48 weight portion～52 weight portions, Fructus Arctii 28 weight portion～32 weight portions, Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portions, Fructus Gardeniae 48 weight portion～52 weight portions, Radix Ophiopogonis 58 weight portion～62 weight portion, Rhizoma Polygonati 48 weight portion～52 weight portions, Radix Pseudostellariae 78 weight portion～82 weight portions, Caulis Polygoni Multiflori 38 weight portion～42 weight portions, Fructus Lycii 58 weight portion～62 weight portions, Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portions, Fructus Schisandrae Chinensis 28 weight portion～32 weight portions, Herba Senecionis Scandentis 23 weight portion～27 weight portions, Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portions, Lignum Sappan 23 weight portion～27 weight portions, Fructus Jujubae 38 weight portion～42 weight portions, Radix Sophorae Tonkinensis 28 weight portion～32 weight portions, Radix Adenophorae 48 weight portion～52 weight portions, Calyx Kaki 23 weight portion～27 weight portions, Fructus Crataegi 28 weight portion～32 weight portions, Semen Raphani 23 weight portion～27 weight portions, Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portions, Semen Euryales 38 weight portion～42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portions, Herba Fici Simplicissimae 33 weight portion～37 weight portions and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portions.
Wherein, in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 30 weight portions, Radix Scutellariae 50 weight portions, Fructus Arctii 30 weight portions, Pseudobulbus Cremastrae Seu Pleiones 40 weight portions, Fructus Gardeniae 50 weight portions, Radix Ophiopogonis 60 weight portion, Rhizoma Polygonati 50 weight portions, Radix Pseudostellariae 80 weight portions, Caulis Polygoni Multiflori 40 weight portions, Fructus Lycii 60 weight portions, Bulbus Fritillariae Thunbergii 25 weight portions, Fructus Schisandrae Chinensis 30 weight portions, Herba Senecionis Scandentis 25 weight portions, Herb Gynostemmae Pentaphylli 50 weight portions, Lignum Sappan 25 weight portions, Fructus Jujubae 40 weight portions, Radix Sophorae Tonkinensis 30 weight portions, Radix Adenophorae 50 weight portions, Calyx Kaki 25 weight portions, Fructus Crataegi 30 weight portions, Semen Raphani 25 weight portions, Ramulus et Folium Bauhiniae Faberi 30 weight portions, Semen Euryales 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portions, Herba Fici Simplicissimae 35 weight portions and Caulis et folium cryptotaeniae japonicae 25 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine immune formulation, is specially:
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder;
Second step, is mixed in proportion remaining component, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder;
The 3rd step, mixes the first dried powder and the second dried powder, obtains Chinese medicine immune formulation powder.
It is a kind of for preventing the feedstuff of infectious bronchitis of chicken that the present invention also provides, and its raw material comprises Semen Maydis, bean cake, Sal, fish flour, bone meal, trace mineral supplement, amino acid additive, vitamin(e) supplement and for preventing the Chinese medicine immune formulation powder feed additive of infectious bronchitis of chicken.
Wherein, in described feedstuff, the weight portion of each material composition is respectively Semen Maydis 90 weight portion～110 weight portions, bean cake 30 weight portion～50 weight portions, Sal 2 weight portion～4 weight portions, fish flour 8 weight portion～12 weight portions, bone meal 3 weight portion～5 weight portions, trace mineral supplement 2 weight portion～4 weight portions, amino acid additive 2 weight portion～4 weight portions, vitamin(e) supplement 2 weight portion～4 weight portions and Chinese medicine immune formulation powder feed additive 15 weight portion～20 weight portions.
Wherein, in described feedstuff, the weight portion of each material composition is respectively Semen Maydis 100 weight portions, bean cake 40 weight portions, Sal 3 weight portions, fish flour 10 weight portions, bone meal 4 weight portions, trace mineral supplement 3 weight portions, amino acid additive 3 weight portions, vitamin(e) supplement 3 weight portions and Chinese medicine immune formulation powder feed additive 18 weight portions.
The present invention also provides the preparation method of above-mentioned feedstuff, is specially:
The first step, prepares described Chinese medicine immune formulation powder feed additive according to the method described above;
Second step, puts into fodder mixing machine together with the described Chinese medicine immune formulation powder feed additive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feedstuff.
Beneficial effect of the present invention:
Chinese medicine immune formulation provided by the invention has significant effect in prevention aspect infectious bronchitis of chicken, and have nontoxic, the advantage of drug resistance, drug residue free.
The specific embodiment
Chinese veterinarian treats infectious bronchitis and adheres to the eliminating evil and large principle of righting two, and eliminating evil is the heresy of dispelling the harmful cause of disease-epidemic disease poison, suppresses or eliminates virulence factor, gets rid of pathological product.Righting is the premunition by enhancing body, improve immunologic function, righting is widely used in various infectious disease all the time, basic principle is yin nourishing Bao Jin, can directly the degrade toxin of pathogen of medicinal herb components, immunologic function that can also enhancing body, by heat-clearing and toxic substances removing, suppress virus, be aided with removing heat-phlegm, antiasthmatic-antitussive reaches eliminating evil object, and the common enhancing human body immunity power of collaborative tonification class Chinese medicine, reaches the object of righting.
Theoretical according to traditional Chinese veterinary medicine, infectious bronchitis of chicken be in epidemic disease poison, invade due to, belong to epidemic febrile disease category, the clinical syndrome in QI system marquis with accumulation of heat in the lung is the most common, accumulation of heat in the lung clearly should mistake department, the heap soil or fertilizer over and around the roots of QI rising in reverse order expectorant, therefore be shown in the diseases such as cough, asthma.Because its characteristic of disease belongs to heat, sick position is at lung, and controlling should heat-clearing and toxic substances removing, should lung relieving asthma, relieving cough and resolving phlegm.
Based on above-mentioned theory of Chinese medical science, the present invention proposes with invigorating the spleen and replenishing QI, and yin nourishing Bao Jin is main, is aided with heat-clearing and toxic substances removing, should lung relievings asthma, relieving cough and resolving phlegm, realizes the prevention to infectious bronchitis of chicken.
The invention provides a kind ofly for preventing the Chinese medicine immune formulation of infectious bronchitis of chicken, its crude drug comprises Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.
Further, described Chinese medicine immune formulation only consists of above-mentioned raw materials medicine.
In side, Herba Sarcandrae anti-inflammation, containing isofraxidin, Fumaric acid, succinic acid, lignum-vitae base lignan, can improve energy metabolism, broad-spectrum antiseptic, virus replication, immunologic function is had to dual regulation, Radix Scutellariae heat-clearing and toxic substances removing has the effect of the bronchospasm of releasing, Fructus Arctii preventing phlegm from forming and stopping coughing, clearing throat, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, Fructus Gardeniae dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, Radix Ophiopogonis nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, Rhizoma Polygonati, Radix Pseudostellariae, the contained saponin of Radix Et Caulis Acanthopanacis Senticosi, polysaccharide, flavonoid, organic acid and vitamin isoreactivity composition, there is strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promote the production of body fluid, the effect of calming the nerves, can significantly improve body's immunity and anti-stress ability, there is antiviral activity, Caulis Polygoni Multiflori can promote hemopoietic function, there is tonic effect, the cough-relieving of Fructus Lycii nourishing YIN and moistening the lung, Bulbus Fritillariae Thunbergii nourishing the lung to arrest cough reduces phlegm, Fructus Schisandrae Chinensis relieving cough and asthma, Herba Senecionis Scandentis heat-clearing and toxic substances removing, Herb Gynostemmae Pentaphylli has facilitation to humoral immunization, Lignum Sappan blood circulation promoting and blood stasis dispelling, Fructus Jujubae air making-up and spleen enlivening, nourishing blood to tranquillize the mind, Radix Sophorae Tonkinensis resolving toxin and disinhibiting the throat, Radix Adenophorae nourishing the lung to arrest cough, nourishing the stomach to promote the production of body fluid, Calyx Kaki lowering the adverse flow of QI, Fructus Crataegi, Semen Raphani invigorating the stomach and promoting digestion, Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing, dampness removing is antipruritic, Semen Euryales supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, Herba Fici Simplicissimae invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, Caulis et folium cryptotaeniae japonicae dispelling wind stopping cough, eliminating damp, detoxifying.
Herba Sarcandrae: latin name Sarcandrae Herba, slightly warm in nature, bitter in the mouth, pungent, has anti-inflammation, dispelling wind and removing obstruction in the collateral, the effect of blood circulation promoting and dispersing pathogen accumulation, cures mainly the cards such as pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature, enters the heart, lung, stomach, gallbladder, large intestine channel, has heat clearing and damp drying, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Fructus Arctii: acrid in the mouth, hardship; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, the lung qi dispersing sore-throat relieving swollen effect of faling apart, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.
Pseudobulbus Cremastrae Seu Pleiones: sweet in the mouth, micro-pungent, cool in nature, return liver, spleen channel, there is heat-clearing and toxic substances removing, the effect of dissipating phlegm and resolving masses, for carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, the cards such as snake bite and insect sting.
Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three warmers, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in epidemic febrile disease heat stagnation breast gastral cavity vexed uneasiness, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The symptoms such as the abdominal distention of qi depression to blood stasis.
Radix Ophiopogonis: latin name Ophiopogonis Radix, sweet in the mouth, micro-hardship, cold nature, enter the heart, lung, stomach warp, have the effect that nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away nourish heart, curing mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat glutinous, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, dry mouth and throat due to thermal burn stomach-Yin or deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and the dry card that waits.
Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and enters spleen, lung meridian, has air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, energy strengthening the spleen gas, nourishing stomach-YIN, the deficiency of the lung cough caused by dryness of hindering for deficiency of vital energy Tianjin and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis, energy supplementing QI for promoting the production of body fluid, controls deficiency of vital energy xeropulmonary cough, the cards such as the cardiopalmus sleeplessness of deficiency of both QI and YIN, hyperhidrosis.
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is flat; GUIXIN, Liver Channel, having can tranquilizing by nourishing the heart, the effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, enter lung, heart channel, there is removing heat-phlegm, the effect of powder detoxifcation, cures mainly cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, the cards such as sore swollen toxin.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, returns lung, the heart, kidney channel, has convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming, cure mainly chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, the card such as interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth, returns lung, Liver Channel, has the effect of heat-clearing and toxic substances removing, improving eyesight dampness removing, have the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema, Herba Senecionis Scandentis has antibacterial activity to staphylococcus aureus, colon bacillus, dysentery bacterium.
Herb Gynostemmae Pentaphylli: cold in nature, sweet in the mouth, return lung, spleen, kidney channel, there is QI invigorating, calm the nerves, the effect of blood pressure lowering, for deficiency of vital energy and physically weak, weak breath is weak; Vexed insomnia; Hypertension, Light-headedness; Viral hepatitis; Digestive tract tumor; Chronic bronchitis, the polysaccharide that Herb Gynostemmae Pentaphylli is rich in can improve serum hemolysin content, and humoral immunization is had to facilitation, and the total saponins that Herb Gynostemmae Pentaphylli is rich in can promote lymphocyte transformation, improves the activity of DNA polysaccharide, promotes the synthetic of lymphocyte DNA.
Lignum Sappan: sweet in the mouth, one-tenth, property is flat, and GUIXIN, liver, spleen channel, have blood circulation promoting and blood stasis dispelling, and the effect of reducing swelling and alleviating pain, cures mainly traumatic injury, fracture muscle and tendon injury, stasis swells and ache, amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine waits card bitterly.
Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp, there is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, the card such as insufficiency of vital energy and blood, has a headache and fever, sweating hot blast.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, enter the heart, lung, large intestine channel, there is resolving toxin and disinhibiting the throat, clearing away heat-damp and promoting diuresis, the effect that parasite killing is anticancer, for laryngopharynx swelling and pain, swelling of the gum toothache, cough due to lung-heat, dysentery, jaundice, the cards such as the swollen tinea alba of heat.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, has nourishing the lung to arrest cough, and the effect of nourishing the stomach to promote the production of body fluid is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, chronic cough expectorant blood, the cards such as deficiency of stomach-Yin, mouthfeel parched throat, constipation, the few tongue of red tongue.
Calyx Kaki: bitter in the mouth, flat, return stomach warp, there is the effect of lowering the adverse flow of QI, cure mainly singultus; Eructation; The cards such as regurgitation.
Sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, and for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. are had to obvious inhibitory action.
Semen Raphani: property is flat, and acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling of helping digestion, the effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant and stops up the card such as breath with cough.
Ramulus et Folium Bauhiniae Faberi: mildly bitter flavor, micro-acid, cool in nature, there is heat-clearing and toxic substances removing, the effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.
Semen Euryales: sweet in the mouth, puckery, property is flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, is with inferior card.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizomaseu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.
Herba Fici Simplicissimae: sweet, tepor, has invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, cures mainly pulmonary tuberculosis cough, chronic bronchitis, rheumatic arthritis, lumbago and skelalgia, insufficiency of the spleen edema, the after being ill card such as night sweat.
Caulis et folium cryptotaeniae japonicae: acrid in the mouth, hardship; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; The effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, and gonorrhea, hernia, acute toothache, carbuncle furuncle is swollen, herpes zoster, the cards such as skin pruritus.
In described Chinese medicine immune formulation, the weight portion of each crude drug is respectively: Herba Sarcandrae 25 weight portion～35 weight portions, Radix Scutellariae 45 weight portion～55 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portions, Fructus Gardeniae 45 weight portion～55 weight portions, Radix Ophiopogonis 55 weight portion～65 weight portion, Rhizoma Polygonati 45 weight portion～55 weight portions, Radix Pseudostellariae 75 weight portion～85 weight portions, Caulis Polygoni Multiflori 35 weight portion～45 weight portions, Fructus Lycii 55 weight portion～65 weight portions, Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portions, Fructus Schisandrae Chinensis 25 weight portion～35 weight portions, Herba Senecionis Scandentis 20 weight portion～30 weight portions, Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portions, Lignum Sappan 20 weight portion～30 weight portions, Fructus Jujubae 35 weight portion～45 weight portions, Radix Sophorae Tonkinensis 25 weight portion～35 weight portions, Radix Adenophorae 45 weight portion～55 weight portions, Calyx Kaki 20 weight portion～30 weight portions, Fructus Crataegi 25 weight portion～35 weight portions, Semen Raphani 20 weight portion～30 weight portions, Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portions, Semen Euryales 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portions, Herba Fici Simplicissimae 30 weight portion～40 weight portions and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portions.
Further preferably, in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 28 weight portion～32 weight portions, Radix Scutellariae 48 weight portion～52 weight portions, Fructus Arctii 28 weight portion～32 weight portions, Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portions, Fructus Gardeniae 48 weight portion～52 weight portions, Radix Ophiopogonis 58 weight portion～62 weight portion, Rhizoma Polygonati 48 weight portion～52 weight portions, Radix Pseudostellariae 78 weight portion～82 weight portions, Caulis Polygoni Multiflori 38 weight portion～42 weight portions, Fructus Lycii 58 weight portion～62 weight portions, Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portions, Fructus Schisandrae Chinensis 28 weight portion～32 weight portions, Herba Senecionis Scandentis 23 weight portion～27 weight portions, Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portions, Lignum Sappan 23 weight portion～27 weight portions, Fructus Jujubae 38 weight portion～42 weight portions, Radix Sophorae Tonkinensis 28 weight portion～32 weight portions, Radix Adenophorae 48 weight portion～52 weight portions, Calyx Kaki 23 weight portion～27 weight portions, Fructus Crataegi 28 weight portion～32 weight portions, Semen Raphani 23 weight portion～27 weight portions, Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portions, Semen Euryales 38 weight portion～42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portions, Herba Fici Simplicissimae 33 weight portion～37 weight portions and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portions.
Further preferred, in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 30 weight portions, Radix Scutellariae 50 weight portions, Fructus Arctii 30 weight portions, Pseudobulbus Cremastrae Seu Pleiones 40 weight portions, Fructus Gardeniae 50 weight portions, Radix Ophiopogonis 60 weight portion, Rhizoma Polygonati 50 weight portions, Radix Pseudostellariae 80 weight portions, Caulis Polygoni Multiflori 40 weight portions, Fructus Lycii 60 weight portions, Bulbus Fritillariae Thunbergii 25 weight portions, Fructus Schisandrae Chinensis 30 weight portions, Herba Senecionis Scandentis 25 weight portions, Herb Gynostemmae Pentaphylli 50 weight portions, Lignum Sappan 25 weight portions, Fructus Jujubae 40 weight portions, Radix Sophorae Tonkinensis 30 weight portions, Radix Adenophorae 50 weight portions, Calyx Kaki 25 weight portions, Fructus Crataegi 30 weight portions, Semen Raphani 25 weight portions, Ramulus et Folium Bauhiniae Faberi 30 weight portions, Semen Euryales 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portions, Herba Fici Simplicissimae 35 weight portions and Caulis et folium cryptotaeniae japonicae 25 weight portions.
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder;
Second step, is mixed in proportion remaining component, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder;
The 3rd step, mixes the first dried powder and the second dried powder, obtains Chinese medicine immune formulation powder.
Chinese medicine immune formulation provided by the invention can be admixed in feedstuff for chicken and take, or is dissolved in water and gavages to chicken.
It is a kind of for preventing the feedstuff of infectious bronchitis of chicken that the present invention also provides, and its raw material comprises Semen Maydis, bean cake, Sal, fish flour, bone meal, trace mineral supplement, amino acid additive, vitamin(e) supplement and for preventing the Chinese medicine immune formulation powder feed additive of infectious bronchitis of chicken.
Further, described feedstuff only consists of above-mentioned raw materials.
Wherein, in described feedstuff, the weight portion of each material composition is respectively Semen Maydis 90 weight portion～110 weight portions, bean cake 30 weight portion～50 weight portions, Sal 2 weight portion～4 weight portions, fish flour 8 weight portion～12 weight portions, bone meal 3 weight portion～5 weight portions, trace mineral supplement 2 weight portion～4 weight portions, amino acid additive 2 weight portion～4 weight portions, vitamin(e) supplement 2 weight portion～4 weight portions and Chinese medicine immune formulation powder feed additive 15 weight portion～20 weight portions.
Further preferably, in described feedstuff, the weight portion of each material composition is respectively Semen Maydis 100 weight portions, bean cake 40 weight portions, Sal 3 weight portions, fish flour 10 weight portions, bone meal 4 weight portions, trace mineral supplement 3 weight portions, amino acid additive 3 weight portions, vitamin(e) supplement 3 weight portions and Chinese medicine immune formulation powder feed additive 18 weight portions.
Trace mineral supplement can be the trace mineral supplement of various routines, can use simple acylate, as ferric citrate, also can use trace element and amino-acid chelate, as aminoacid ferrum, the trace element adding mainly contains ferrum, zinc, copper, manganese, iodine, cobalt, selenium, molybdenum, also can use composite trace element premix, Great Britain and America's that sharp keeping normal life activities thing science and technology limited Company as excellent in Beijing provides.
Amino acid additive comprises the various conventional aminoacid such as serine, glutamic acid, glycine, isoleucine, leucine, alanine, proline, also can adopt aminoacid premix material, the Aminoacids complex powder that as above sea cowry energy Chemical Co., Ltd. produces.
Vitamin(e) supplement comprises the various conventional vitamin such as riboflavin, vitamin C, vitamin E, vitamin A, vitamin B, also can adopt vitamin premix, as plain in the excellent dimension that Beijing You Libao Bioisystech Co., Ltd produces.
The present invention also provides the preparation method of above-mentioned feedstuff, is specially:
The first step, prepares described Chinese medicine immune formulation powder feed additive according to the method described above;
Second step, puts into fodder mixing machine together with the described Chinese medicine immune formulation powder feed additive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feedstuff.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine immune formulation 1
By 60g Radix Ophiopogonis, Rhizoma Polygonati 50g, Radix Pseudostellariae 80g, Caulis Polygoni Multiflori 40g, Fructus Lycii 60g, Herb Gynostemmae Pentaphylli 50g, Fructus Jujubae 40g, Radix Adenophorae 50g, Semen Euryales 40g and Radix Et Caulis Acanthopanacis Senticosi 35g are mixed in proportion, and get mixture 100g and pack in percolator, add the Chinese liquor 700g of 50 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 800mL, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder, by Herba Sarcandrae 30g, Radix Scutellariae 50g, Fructus Arctii 30g, Pseudobulbus Cremastrae Seu Pleiones 40g, Fructus Gardeniae 50g, Bulbus Fritillariae Thunbergii 25g, Fructus Schisandrae Chinensis 30g, Herba Senecionis Scandentis 25g, Lignum Sappan 25g, Radix Sophorae Tonkinensis 30g, Calyx Kaki 25g, Fructus Crataegi 30g, Semen Raphani 25g, Ramulus et Folium Bauhiniae Faberi 30g, Herba Fici Simplicissimae 35g and Caulis et folium cryptotaeniae japonicae 25g mix, and get 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder, the first dried powder and the second dried powder are mixed, obtain Chinese medicine immune formulation 1.
Embodiment 2 Chinese medicine immune formulations 2
By 58g Radix Ophiopogonis, Rhizoma Polygonati 48g, Radix Pseudostellariae 78g, Caulis Polygoni Multiflori 38g, Fructus Lycii 58g, Herb Gynostemmae Pentaphylli 48g, Fructus Jujubae 38g, Radix Adenophorae 48g, Semen Euryales 38g and Radix Et Caulis Acanthopanacis Senticosi 33g are mixed in proportion, and get mixture 100g and pack in percolator, add the Chinese liquor 700g of 50 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 800mL, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder, by Herba Sarcandrae 28g, Radix Scutellariae 48g, Fructus Arctii 28g, Pseudobulbus Cremastrae Seu Pleiones 38g, Fructus Gardeniae 48g, Bulbus Fritillariae Thunbergii 23g, Fructus Schisandrae Chinensis 28g, Herba Senecionis Scandentis 23g, Lignum Sappan 23g, Radix Sophorae Tonkinensis 28g, Calyx Kaki 23g, Fructus Crataegi 28g, Semen Raphani 23g, Ramulus et Folium Bauhiniae Faberi 28g, Herba Fici Simplicissimae 33g and Caulis et folium cryptotaeniae japonicae 23g mix, and get 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder, the first dried powder and the second dried powder are mixed, obtain Chinese medicine immune formulation 2.
Embodiment 3 Chinese medicine immune formulations 3
By 62g Radix Ophiopogonis, Rhizoma Polygonati 52g, Radix Pseudostellariae 82g, Caulis Polygoni Multiflori 42g, Fructus Lycii 62g, Herb Gynostemmae Pentaphylli 52g, Fructus Jujubae 42g, Radix Adenophorae 52g, Semen Euryales 42g and Radix Et Caulis Acanthopanacis Senticosi 37g are mixed in proportion, and get mixture 100g and pack in percolator, add the Chinese liquor 700g of 50 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 800mL, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder, by Herba Sarcandrae 32g, Radix Scutellariae 52g, Fructus Arctii 32g, Pseudobulbus Cremastrae Seu Pleiones 42g, Fructus Gardeniae 52g, Bulbus Fritillariae Thunbergii 27g, Fructus Schisandrae Chinensis 32g, Herba Senecionis Scandentis 27g, Lignum Sappan 27g, Radix Sophorae Tonkinensis 32g, Calyx Kaki 27g, Fructus Crataegi 32g, Semen Raphani 27g, Ramulus et Folium Bauhiniae Faberi 32g, Herba Fici Simplicissimae 37g and Caulis et folium cryptotaeniae japonicae 27g mix, and get 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder, the first dried powder and the second dried powder are mixed, obtain Chinese medicine immune formulation 3.
Embodiment 4 toxicological experiments
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, by Qingdao City's Experimental Animal Center, provided, the Chinese medicine immune formulation of embodiment 1 preparation is dissolved in water, obtain the solution that crude drug concentration is 1g/ml, gavage mice, through preliminary experiment, fail to detect the LD of oral administration
50, therefore survey its maximum tolerated dose, administration volume with 1.4ml/10g body weight, gavage 2 times/d, interval 6h, give observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, all animals is processed, dissect, each main organs lesion tissue situation of perusal, gavage for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, observe 7d animal dead, gross necropsy has no the obviously abnormal of main organs tissue, therefore, the maximum dosage-feeding of Chinese medicine granules is >140g crude drug/kg, this dosage is equivalent to 70 times of maximum oral dose 2g crude drug/kg clinical adult (by 60kg) every day.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, by Qingdao City's Experimental Animal Center, provided, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, the Chinese medicine immune formulation of embodiment 1 preparation is dissolved in water, obtain the solution that crude drug concentration is 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, observe rat general state every day before administration and during administration, sign, food ration, drinking-water and feces situation.During administration 90d, after last administration 24h, each group extracts 6, male and female half and half; During 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, each group of 30d extracts 6, male and female half and half, with urethane, anaesthetize, from abdominal aortic, get blood, each group is all killed and is got animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, it is dead that animal has no, naked eyes have no obvious pathological changes, each organizes the inspection of rat peripheral hemogram all in normal range, and physiochemical indice is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is compared and be there is no significant difference with blank group.
Embodiment 5 feedstuffs 1
Together with Chinese medicine immune formulation 1.8kg prepared by Semen Maydis 10kg, bean cake 4kg, Sal 0.3kg, fish flour 0.1kg, bone meal 0.4kg, trace mineral supplement Great Britain and America that (the excellent sharp keeping normal life activities thing science and technology limited Company in Beijing provides) 0.3kg, amino acid additive Aminoacids complex powder (above sea cowry energy Chemical Co., Ltd. produces) 0.3kg, excellent dimension element (production of Beijing You Libao Bioisystech Co., Ltd) 0.3kg of vitamin(e) supplement and embodiment 1, put into fodder mixing machine, continuous uniform stirred after 3 hours, put into pulverizer and pulverize, obtain feedstuff 1.
Comparative example 1 feedstuff 2
Semen Maydis 10kg, bean cake 4kg, Sal 0.3kg, fish flour 0.1kg, bone meal 0.4kg, trace mineral supplement Great Britain and America that (the excellent sharp keeping normal life activities thing science and technology limited Company in Beijing provides) 0.3kg, amino acid additive Aminoacids complex powder (above sea cowry energy Chemical Co., Ltd. produces) 0.3kg, the excellent dimension element of vitamin(e) supplement (production of Beijing You Libao Bioisystech Co., Ltd) 0.3kg are put into fodder mixing machine together, continuous uniform stirred after 3 hours, put into pulverizer and pulverize, obtain feedstuff 2.
Embodiment 6 zooperies
Laboratory animal
Select 400 of the healthy SPF chickens of 7 ages in days, by Qingdao, Nanjing brocade laboratory animal company limited provides, and without infectious bronchitis vaccine epidemic prevention, is divided at random 4 groups, 100 every group.
Normal healthy controls group: counteracting toxic substances not, do not feed any medicine, isolated rearing, feeding corn feed.
Counteracting toxic substances matched group: after counteracting toxic substances, do not feed any medicine, isolated rearing, feeding corn feed.
Prevent 1 group: counteracting toxic substances starts the feedstuff 1 of feeding embodiment 5 preparations for first 3 days.
Prevent 2 groups: counteracting toxic substances starts the feedstuff 2 of feeding comparative example 1 preparation for first 3 days.
Experimental drug
The feedstuff 2 of the feedstuff 1 of embodiment 5 preparations and comparative example 1 preparation.
Infectious bronchitis virus
Counteracting toxic substances provides with IBV M41 virulent strain ，You China Veterinary Drugs Supervisory Inst., during use, viral 1:10 by trachea inoculation test chicken 0.2ml/ is only diluted.
Symptom classification and curative effect judging standard
Through trial test, determine that the infective dose of IBV-M41 strain kind poison is that every plumage 0.2mL carries out collunarium inoculation.When the most chickens morbidity of counteracting toxic substances matched group, each group chicken is carried out to clinical symptoms and score, and test chicken is cutd open to inspection, cut open and examine symptom and score, calculate each group result of scoring, according to curative effect judging standard, conclude.Clinical symptoms classification, cut open inspection symptom classification and curative effect determinate standard specific as follows:
Clinical symptoms classification
One-level (0 minute): the chicken mental status is good, diet is wanted, activity is all normal.
Secondary (1 minute): be discontinuity cough, accidental nasal cavity has mucus, gets rid of head, and food effect is little, and walking is normal.
Three grades (2 minutes): dyspnea, trachea has rale, and spirit is depressed, and feather is contrary vertical, peels off slow-witted vertical, and appetite declines or does not eat.
Level Four (3 minutes): dyspnea, death by suffocation.
Cut open the classification of inspection symptom
One-level (0 minute): without obviously pathological change.
Secondary (1 minute): nasal cavity has mucus secretions, has thin mucus secretions in trachea and bronchus.The micro-muddiness of air bag.
Three grades (2 minutes): in trachea hypomere and bronchus, have the secretions of more thickness, have no hemorrhage, air bag thickens.
Level Four (3 minutes): have yellow cheesy exudate in trachea hypomere and bronchus.Some trachea hypomeres and bronchus place have ring-type hemorrhage.Air bag thickens.
Curative effect determinate standard
Effective: refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, main clinic symptoms, the pathological change of morbidity chicken obviously improve, i.e. 60%< therapeutic index <100%.
Effective: refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, main clinic symptoms, the pathological change of morbidity chicken make moderate progress, i.e. 30%< therapeutic index <60%.
Invalid: refer to 48h after counteracting toxic substances, prevention group is compared with counteracting toxic substances matched group, main clinic symptoms, the pathological change of morbidity chicken is not improved or adds to some extent severe one, i.e. therapeutic index <30%.
To note: therapeutic index=(score-prevention of counteracting toxic substances matched group group is scored) ÷ counteracting toxic substances matched group scores * and 100%.
Date processing and analysis
Each is organized data and all uses mean soil standard deviation
represent, each is organized mean and does test of normality and repeated measure homogeneity test of variance, younger check between organizing with one factor analysis of variance), P<0.05 is for differing significantly, and P<0.01 is for differing highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Result
There is significantly cough in counteracting toxic substances matched group most of chicken after counteracting toxic substances 48h, the symptoms such as rale, dyspnea appear in part chicken, and sick chicken spirit is depressed, poor appetite, dead chicken is cutd open to inspection, occur infectious bronchitis of chicken typical case pathological change, counteracting toxic substances success is described.
Chinese medicine immune formulation of the present invention to the preventive effect of infectious bronchitis of chicken in Table 1.
The preventive effect of table 1 Chinese medicine immune formulation to infectious bronchitis of chicken
As can be seen from Table 1, the prevention group that adopts the prevention group sickness rate of Chinese medicine immune formulation of the present invention to be significantly less than counteracting toxic substances matched group and not add Chinese medicine immune formulation of the present invention, illustrates that the preventive effect of this Chinese medicine immune formulation is remarkable.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. for preventing a Chinese medicine immune formulation for infectious bronchitis of chicken, it is characterized in that: crude drug comprises Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae.
2. Chinese medicine immune formulation as claimed in claim 1, is characterized in that: in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 25 weight portion～35 weight portions, Radix Scutellariae 45 weight portion～55 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portions, Fructus Gardeniae 45 weight portion～55 weight portions, Radix Ophiopogonis 55 weight portion～65 weight portion, Rhizoma Polygonati 45 weight portion～55 weight portions, Radix Pseudostellariae 75 weight portion～85 weight portions, Caulis Polygoni Multiflori 35 weight portion～45 weight portions, Fructus Lycii 55 weight portion～65 weight portions, Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portions, Fructus Schisandrae Chinensis 25 weight portion～35 weight portions, Herba Senecionis Scandentis 20 weight portion～30 weight portions, Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portions, Lignum Sappan 20 weight portion～30 weight portions, Fructus Jujubae 35 weight portion～45 weight portions, Radix Sophorae Tonkinensis 25 weight portion～35 weight portions, Radix Adenophorae 45 weight portion～55 weight portions, Calyx Kaki 20 weight portion～30 weight portions, Fructus Crataegi 25 weight portion～35 weight portions, Semen Raphani 20 weight portion～30 weight portions, Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portions, Semen Euryales 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portions, Herba Fici Simplicissimae 30 weight portion～40 weight portions and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portions.
3. Chinese medicine immune formulation as claimed in claim 1 or 2, is characterized in that: in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 28 weight portion～32 weight portions, Radix Scutellariae 48 weight portion～52 weight portions, Fructus Arctii 28 weight portion～32 weight portions, Pseudobulbus Cremastrae Seu Pleiones 38 weight portion～42 weight portions, Fructus Gardeniae 48 weight portion～52 weight portions, Radix Ophiopogonis 58 weight portion～62 weight portion, Rhizoma Polygonati 48 weight portion～52 weight portions, Radix Pseudostellariae 78 weight portion～82 weight portions, Caulis Polygoni Multiflori 38 weight portion～42 weight portions, Fructus Lycii 58 weight portion～62 weight portions, Bulbus Fritillariae Thunbergii 23 weight portion～27 weight portions, Fructus Schisandrae Chinensis 28 weight portion～32 weight portions, Herba Senecionis Scandentis 23 weight portion～27 weight portions, Herb Gynostemmae Pentaphylli 48 weight portion～52 weight portions, Lignum Sappan 23 weight portion～27 weight portions, Fructus Jujubae 38 weight portion～42 weight portions, Radix Sophorae Tonkinensis 28 weight portion～32 weight portions, Radix Adenophorae 48 weight portion～52 weight portions, Calyx Kaki 23 weight portion～27 weight portions, Fructus Crataegi 28 weight portion～32 weight portions, Semen Raphani 23 weight portion～27 weight portions, Ramulus et Folium Bauhiniae Faberi 28 weight portion～32 weight portions, Semen Euryales 38 weight portion～42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 33 weight portion～37 weight portions, Herba Fici Simplicissimae 33 weight portion～37 weight portions and Caulis et folium cryptotaeniae japonicae 23 weight portion～27 weight portions.
4. the Chinese medicine immune formulation as described in claims 1 to 3, it is characterized in that: in described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 30 weight portions, Radix Scutellariae 50 weight portions, Fructus Arctii 30 weight portions, Pseudobulbus Cremastrae Seu Pleiones 40 weight portions, Fructus Gardeniae 50 weight portions, Radix Ophiopogonis 60 weight portion, Rhizoma Polygonati 50 weight portions, Radix Pseudostellariae 80 weight portions, Caulis Polygoni Multiflori 40 weight portions, Fructus Lycii 60 weight portions, Bulbus Fritillariae Thunbergii 25 weight portions, Fructus Schisandrae Chinensis 30 weight portions, Herba Senecionis Scandentis 25 weight portions, Herb Gynostemmae Pentaphylli 50 weight portions, Lignum Sappan 25 weight portions, Fructus Jujubae 40 weight portions, Radix Sophorae Tonkinensis 30 weight portions, Radix Adenophorae 50 weight portions, Calyx Kaki 25 weight portions, Fructus Crataegi 30 weight portions, Semen Raphani 25 weight portions, Ramulus et Folium Bauhiniae Faberi 30 weight portions, Semen Euryales 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portions, Herba Fici Simplicissimae 35 weight portions and Caulis et folium cryptotaeniae japonicae 25 weight portions.
5. the preparation method of Chinese medicine immune formulation described in claim 1 to 4, is characterized in that, comprising:
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder;
Second step, is mixed in proportion remaining component, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder;
The 3rd step, mixes the first dried powder and the second dried powder, obtains Chinese medicine immune formulation.
6. for preventing a Chinese medicine immune formulation powder for infectious bronchitis of chicken, it is characterized in that: crude drug comprises Herba Sarcandrae, Radix Scutellariae, Fructus Arctii, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gardeniae, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Bulbus Fritillariae Thunbergii, Fructus Schisandrae Chinensis, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, Lignum Sappan, Fructus Jujubae, Radix Sophorae Tonkinensis, Radix Adenophorae, Calyx Kaki, Fructus Crataegi, Semen Raphani, Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Radix Et Caulis Acanthopanacis Senticosi, Herba Fici Simplicissimae and Caulis et folium cryptotaeniae japonicae;
The preparation method of described Chinese medicine immune formulation is specially,
The first step, Radix Ophiopogonis, Rhizoma Polygonati, Radix Pseudostellariae, Caulis Polygoni Multiflori, Fructus Lycii, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Adenophorae, Semen Euryales and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dried powder;
Second step, is mixed in proportion remaining component, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second dried powder;
The 3rd step, mixes the first dried powder and the second dried powder, obtains Chinese medicine immune formulation powder.
7. Chinese medicine immune formulation powder as claimed in claim 6, is characterized in that:
In described Chinese medicine immune formulation, the weight portion of each crude drug is respectively Herba Sarcandrae 25 weight portion～35 weight portions, Radix Scutellariae 45 weight portion～55 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Pseudobulbus Cremastrae Seu Pleiones 35 weight portion～45 weight portions, Fructus Gardeniae 45 weight portion～55 weight portions, Radix Ophiopogonis 55 weight portion～65 weight portion, Rhizoma Polygonati 45 weight portion～55 weight portions, Radix Pseudostellariae 75 weight portion～85 weight portions, Caulis Polygoni Multiflori 35 weight portion～45 weight portions, Fructus Lycii 55 weight portion～65 weight portions, Bulbus Fritillariae Thunbergii 20 weight portion～30 weight portions, Fructus Schisandrae Chinensis 25 weight portion～35 weight portions, Herba Senecionis Scandentis 20 weight portion～30 weight portions, Herb Gynostemmae Pentaphylli 45 weight portion～55 weight portions, Lignum Sappan 20 weight portion～30 weight portions, Fructus Jujubae 35 weight portion～45 weight portions, Radix Sophorae Tonkinensis 25 weight portion～35 weight portions, Radix Adenophorae 45 weight portion～55 weight portions, Calyx Kaki 20 weight portion～30 weight portions, Fructus Crataegi 25 weight portion～35 weight portions, Semen Raphani 20 weight portion～30 weight portions, Ramulus et Folium Bauhiniae Faberi 25 weight portion～35 weight portions, Semen Euryales 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 30 weight portion～40 weight portions, Herba Fici Simplicissimae 30 weight portion～40 weight portions and Caulis et folium cryptotaeniae japonicae 20 weight portion～30 weight portions.
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| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicament for preventing and controlling infectious bronchitis |
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| CN101647968A (en) * | 2009-08-31 | 2010-02-17 | 李敬云 | Traditional Chinese medicine composition for treating chicken infectious bronchitis |
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| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicament for preventing and controlling infectious bronchitis |
| CN101524479A (en) * | 2009-04-15 | 2009-09-09 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for curing avian infectious bronchitis |
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