CN103040975B - Traditional Chinese medicine composition for nursing and treating infantile diarrhea - Google Patents

Traditional Chinese medicine composition for nursing and treating infantile diarrhea Download PDF

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CN103040975B
CN103040975B CN201310040393.4A CN201310040393A CN103040975B CN 103040975 B CN103040975 B CN 103040975B CN 201310040393 A CN201310040393 A CN 201310040393A CN 103040975 B CN103040975 B CN 103040975B
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chinese medicine
medicine composition
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infantile diarrhea
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厉明秀
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Nantong Hongci Pharmaceutical Co Ltd
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崔合芳
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Abstract

The invention discloses a traditional Chinese medicine composition for nursing and treating infantile diarrhea, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: pomegranate bark, apple peel, endothelium corneum gigeriae galli, clove, hairyvein agrimony, purslane and white atractylodes rhizome. The traditional Chinese medicine composition for treating infantile diarrhea, disclosed by the invention, is quick in curative effect, the infantile diarrhea can be cured in one day generally, the cure rate can be more than 98%, and no recurrence is caused after curing. The traditional Chinese medicine composition disclosed by the invention is simple in prescription, herbal medicines in the prescription are less, raw materials are available, cheap and easy to obtain, and a preparation process is simple.

Description

A kind of Chinese medicine composition for the nursing for treating infantile diarrhea
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of infantile diarrhea.
Background technology
Infantile diarrhea is divided into infectious and non-infectious two classes according to the cause of disease, be by many cause of diseases, multifactor cause take the one group clinical syndrome of diarrhoea as leading.Age of onset is many below 2 years old, within 1 years old, with interior person, accounts for 50%.Every day is died from the child of diarrhoea up to 5,000,000~1,800 ten thousand in the whole world.In China, infantile diarrhea is the 2nd commonly encountered diseases, the frequently-occurring disease that is only second to respiratory tract infection.General multiple summer, autumn, take warm, stagnant and intestinal infection as main.Infantile diarrhea has many reasons to cause, but basically with wet, fills pass, moreover children's's visceral peritoneum is tender and lovely, the spleen tending to insufficiency usually, once internal damage caused by infantile dyspepsia, affection of exogenous wind-cold, makes dysfunction of spleen and stomach, can not digest breast and eat heresy of summer-heat, impairing the spleen and stomach.Make clear QI being mixed up with turbid QI, the large intestine of making a bet, and for having loose bowels.
Chinese invention patent: a kind of Chinese medicine composition (CN 100358549) for the treatment of diarrhoeal diseases discloses a kind of Chinese medicine formula: it is that raw material is made by Rhizoma Coptidis, Radix Scutellariae, the Radix Paeoniae Alba, Herba Pogostemonis, Folium Psidii Guajavae, Poria.It has the effect of heat-clearing and toxic substances removing, scorching antidiarrheal, but its course for the treatment of is long, generally needs within 3 days, cure, and cure rate is also lower.
Chinese invention patent: a kind of Chinese medicine formula (application number 200910229336.4) for the treatment of infantile diarrhea discloses a kind of Chinese medicine formula for the treatment of infantile diarrhea, and this prescription is mainly filled a prescription and is comprised of Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae, Folium Perillae, Pericarpium Citri Reticulatae, the stir-fry Radix Aucklandiae, Rhizoma Zingiberis Recens, Fructus Jujubae, Semen Coicis.This patent does not have to disclose the therapeutic effect of this invention.
Chinese invention patent: a kind of Chinese medicine for the treatment of infantile diarrhea and preparation method thereof (CN 101306177 B) discloses a kind of Chinese medicine for the treatment of infantile diarrhea and preparation method thereof, first by Poria, Semen Lablab Album, RHIIZOMA DIOSCOREAE fr0m Henan of China, Semen Coicis, Semen Nelumbinis, Radix Sanguisorbae, Semen Plantaginis, Rhizoma Coptidis is ground into fine powder after by above-mentioned weight proportion, it being concocted, again by Fructus Mume, Radix Platycodonis, Radix Glycyrrhizae, Fructus Aurantii, the Radix Paeoniae Alba, Semen Myristicae, Fructus Amomi, the Radix Aucklandiae, Radix Scutellariae is decocted it to concentrated solution by above-mentioned weight proportion, then by fine powder and its mixing and stirring pulverized, grind after lyophilization and make powder for smalls.These patent flavour of a drug are many, and complicated, and preparation technology is loaded down with trivial details.
Existing marketed drugs Chinese medicine has Medilac-Vita, treating infant diarrhea speed to stop and the French dioctahedral smectite of winning the good fortune pharmacy, Medilac-Vita contains two kinds of viable bacterias: bacillus subtilis and enterococcus, can directly supplement the normal physiological flora, suppress pathogenic bacterium, promote digestion, the absorption of nutrient substance, suppress generation and the absorption of intestinal source property toxin, reach the purpose of adjusting dysbacteriosis in intestinal, though this medication effect is good, easily repeatedly, radical rate is low for the state of an illness.Rush down speed and stop by Herba Euphorbiae Humifusae, obtain Siberian cocklebur, Radix Glycyrrhizae, catechu etc. and form, have the effects such as clearing heat and expelling damp, invigorating the spleen to arrest diarrhea, dispel emphatically pathogen, repair deficiency, recover digestive and absorptive functions, but lack the defencive function to gastrointestinal.Dioctahedral smectite mainly, by the gastrointestinal protection, stops bacterial virus in the gastrointestinal field planting, and cell is repaired as early as possible, the auxiliary reparation suffered for want of medical supplies and adjusting humoral effect.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of invigorating the spleen and regulating the stomach, promoting diuresis to eliminate damp pathogen and middle antidiarrheal, highly effective and safe, wide adaptability, to solve the existing existing deficiency of Chinese medicine preparation.
The present invention for achieving the above object, is achieved through the following technical solutions:
A kind of Chinese medicine composition for the nursing for treating infantile diarrhea of the present invention, made by the raw material of Chinese medicine of following weight portion: Pericarpium Granati 6-10 part, Pericarpium Mali pumilae 6-10 part, Endothelium Corneum Gigeriae Galli 4-6 part, Flos Caryophylli 3-6 part, Herba Agrimoniae 0.2-1.2 part, Herba Portulacae 6-9 part, Rhizoma Atractylodis Macrocephalae 3-6 part.
The present invention, for the Chinese medicine composition of nursing for treating infantile diarrhea, is preferably made by the raw material of Chinese medicine of following weight portion: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
The present invention can also comprise pharmaceutically acceptable adjuvant for the Chinese medicine composition of nursing for treating infantile diarrhea, such as glucose powder, edible or medicinal essence etc.
The present invention can make any peroral dosage form on pharmaceutics for the Chinese medicine composition of nursing for treating infantile diarrhea, as tablet, pill, powder, capsule etc., and preferred powder.
Side of the present invention separates:
Pericarpium Granati: be the peel of Punicaceae plant Punica granatum L..Sour in the mouth, puckery, warm in nature.Return large intestine channel.Function cures mainly: relieving diarrhea with astringents, killing parasites for relieving itching.Astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies." not Lu ": " treat dysentery, the leak-stopping essence." " property of medicine opinion ": " control muscles and bones wind, the waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea, stop red white dysentery.Extracting juice stops under order tear, controls Lou essence." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control with the passing of time watery diarrhea, with frying Saccharum Sinensis Roxb., simmer clothes, control again the dysentery pus and blood, the large intestine hematochezia.Decoct and control children's's infantile malnutrition worm with Fructus Aristolochiae." " detailed outline ": " antidiarrheal dysentery, hematochezia, proctoptosis, metrorrhagia leukorrhagia." the existing clinical treatment that is commonly used to: bacillary dysentery, amebic dysentery and multi-infection inflammation.
Pericarpium Mali pumilae: be the peel of rosaceous plant Fructus Mali pumilae; Nature and flavor are sweet; Cool.Gui Jing: stomach warp.Function cures mainly: normalizing the stomach by guiding QI downward.Main regurgitation." this sketch of the southern regions of the Yunnan Province is said ": control regurgitation and spit.
Endothelium Corneum Gigeriae Galli: be the dry gizzard inwall (muscular stomach) of Chordata Phasianidae animal man chicken.Nature and flavor are sweet, flat.Be included into the taste warp.The promoting digestion and invigorating the stomach activating the spleen, dissipating blood stasis fossil, arresting seminal emission." Records of Tradition Chinese and Western Medicine in Combination ": Endothelium Corneum Gigeriae Galli, the taste of chicken also, in have porcelain stone, copper, ferrum all can digest, its kindization alluvial, placed in the middle burnt with the lifting gasification, if alluvial is arranged, gasification can not lifting, is easily to cause distension, with Endothelium Corneum Gigeriae Galli, is organotherapy, if, again with the Rhizoma Atractylodis Macrocephalae etc. use, be the key medicine of digestion alluvial, the more quality goods of tonifying the spleen and stomach, the taste stalwartness, benefit can transporting the efficacy of a drug with removing food stagnancy also, not only can the diabetes with polyphagia as the prominent symptom stomach long-pending, no matter where internal organs have long-pendingly, and Endothelium Corneum Gigeriae Galli all can disappear it.
Flos Caryophylli: suffering, temperature." Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel.Materia Medica of Decoction: " lunar, bright, the shaoyin channel of foot sun of starting with." " Thunder God is concocted property of medicine solution ": " enter lung, spleen, stomach, kidney four warps." " book on Chinese herbal medicine is newly organized ": " Flos Caryophylli, have female, male dividing, and in fact cures the disease without dividing each other.Acrid in the mouth, temperature, pure sun is nontoxic.Enter kidney, stomach two warps, walk again lunar lungs." function cures mainly: warming middle-JIAO to send down the adverse QI, pain relieving cure mainly coldness and pain in the epigastrium, and vomiting, have loose bowels.Containing volatile oil, it is Oleum Caryophylli.Bacillus pestis, vibrio cholera, anthrax bacillus, dysentery bacterium, escherichia coli are had to inhibitory action.
Herba Agrimoniae: nature and flavor are bitter, hot." BAICAO mirror " carries, and " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness." " medicine mirror pick up any lost article from the road tax ": " and roll the expectorant of pharynx diaphragm, the sound of vomiting of flat regurgitation of food from the stomach, the bitter in the mouth suffering is put down into lungs, wears intestinal and wears stomach and can assault fortified position, and collects stem and leaf and smashes juice use, and the cane-juice spirit assistant makes complete, expectorant verticalization of dysphagic drink, Tianjin is swallowed and is calmed down merit at first.No matter " men and women, old and young, abdominal distention diarrhoea is had to specially good effect with it.
Herba Portulacae: another name long life dish, longevity greens/mustard green, five elements' grass, hornet dish, horse horse dish.Cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Effect: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxify treating stranguria, the rear sweating due to debility of managing property.The Herba Portulacae stem and leaf, containing nicotinic acid, Saponin, tannin, carbamide etc., has broad-spectrum antibacterial action, and dysentery, typhoid fever etc. is had to effect preferably.Experiment in vitro, Herba Portulacae has and suppresses or killing action various dysentery bacterium.Clinical report, Herba Portulacae, to various bacterial dysentery and suppurative illness, all has good result.
The Rhizoma Atractylodis Macrocephalae: another name mountain Ji, poplar Serrata Ji, art, yellor rocket, day Ji, Alpinia japonica (Thunb.) Miq., Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, QI LI JIA, the winter Rhizoma Atractylodis Macrocephalae.Perennial herb, be used as medicine with rhizome, has multinomial medicinal function.Effect: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
The present invention also provides the preparation method of the Chinese medicine composition of described treatment infantile diarrhea, comprises following steps: take each component by above-mentioned weight portion, after pulverizing, cross 120 mesh sieves, and mix homogeneously, sterilizing, be distributed into bottle, makes powder of the present invention.
The present invention compared with prior art has the following advantages for the Chinese medicine composition of nursing for treating infantile diarrhea:
1, curative effect is fast, within general one day, can cure, and more than cure rate can reach 98 ﹪, and non-relapse after healing;
2, flavour of a drug are few, and raw material is without in great shortage, cheap and easy to get, and preparation technology is simple;
3, the present invention is that pure Chinese medicinal preparation, dosage are few, is convenient to the child and takes, and has no side effect;
4, all medicine 5 use of the present invention can increase child's immunity of organisms.
For further investigating clinical efficacy and the safety of medicine of the present invention, select 100 routine infantile diarrhea patients to carry out clinical observation to the curative effect of medicine of the present invention.
60 routine cases are divided into to two groups at random, treatment group 60 examples, matched group 40 examples.Case all, according to the diagnostic criteria of " disease of tcm Standardization of diagnosis and curative effect ", is diagnosed as infantile diarrhea.
Diagnostic criteria:
1. times of defecation increases, and every day 3-5 time, nearly, more than 10 times, is faint yellow, and as egg soup sample, or color is brown and smelly, and a small amount of mucus can be arranged.Or with feeling sick, vomiting, stomachache, heating, thirstyly wait disease;
2. excess in feeding is arranged, unhygienic diet or experience the medical history of seasonal pathogen;
3. severe one is suffered from diarrhoea and the vomiting more severe case, visible oliguria, and fervescence, excessive thirst god withers, and skin is shrivelled, sunken fontanel, the order pearl is sunk, crying without tears, the lip cherry is red, breathes the diseases such as profound, abdominal distention;
4. the stool microscopy can have Oil globule, a small amount of red white corpuscle;
5. the stool pathogenic examination can have the growths such as Escherichia coli, or separates rotavirus etc.;
6. severe diarrhea has dehydration, acid base imbalance and electrolyte disturbance;
Therapeutic Method
Matched group adopts dioctahedral smectite, oral, the child: below 1 years old, 1 bag of every day, minute take for 3 times: 1-2 year: every day the 1-2 bag, minute take for 3 times, more than 2 years old: every day the 2-3 bag, minute take for 3 times.The powder agent medicine that treatment group adopts Chinese medicinal composition preparation embodiment 1 of the present invention to make is treated, below 1 years old, and every day 3 times, each 2 grams.1-2 year: every day 3 times, each 3 grams.More than 2 years old: every day 3 times, each 4 grams.It within 7 days, is a course for the treatment of.
Criterion of therapeutical effect
Formulate following the standard of curative effect evaluation according to " subproposal of diarrhoeal diseases curative effect judging standard " of the revision of the whole nation, Beijing in 1998 organizing committee of diarrhoea prevention scientific seminar:
Cure:
Treat in 2 days, the diarrhoea number of times reduces in 3 times, diarrhoea total amount<150ml, and in 3 days, feces shape and number of times recover normal, and General Symptoms disappears.
Effectively:
In medication 2 days, the diarrhoea number of times reduces in 5 times, diarrhoea total amount<250ml, and in 3 days, feces shape and number of times are clearly better, and General Symptoms obviously improves.
Invalid:
In medication 2 days, diarrhoea number of times still more than 5 times, diarrhoea total amount>300 ml, in 3 days, excrement shape, number of times and General Symptoms are without being clearly better to deterioration.
Total effective rate n(%)=recovery from illness n(%)+effective n(%)
After two groups of case treatments, the curative effect comparative result is in Table 1.
After table 1 liang group case treatment, curative effect relatively
Group Number of cases Recovery from illness n(%) Effective n(%) Invalid n(%) Total effective rate n(%)
Matched group 40 21(52.5) 10(25) 9(22.5) 31(77.5)
Treatment group 60 49(81.7) 10(16.7) 1(1.7) 59(98.3)
Statistical result showed, the treatment group curative effect obviously is better than matched group, and two group differences are remarkable, p<0.05.Through the clinical experiment checking, Chinese medicine composition group of the present invention can be fully recovered in general two days, and within two days, cure rate can reach more than 80%, and total effective rate can reach 98.3%.
The specific embodiment
Following examples are used for the present invention is described, but are not used for limiting the scope of the invention.
example of formulations 1:
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.
example of formulations 2
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 6 parts of Pericarpium Granatis, 6 parts of Pericarpium Mali pumilaes, 4 parts of Endothelium Corneum Gigeriae Galli, 3 parts of Flos Caryophyllis, 0.2 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 3 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.
example of formulations 3
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 10 parts of Pericarpium Granatis, 10 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Flos Caryophyllis, 1.2 parts of Herba Agrimoniaes, 9 parts of Herba Portulacaes, 6 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.
example of formulations 4
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 4 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.6 part of Herba Agrimoniae, 8 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.
example of formulations 5
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of glucoses.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.
example of formulations 6
The present invention is for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the preparation of raw material by following weight portion forms: 10 parts of Pericarpium Granatis, and 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, edible essence is appropriate.
Its preparation process is as follows: take each component by above-mentioned weight, after pulverizing, cross 120 mesh sieves, mix sterilizing, be distributed into bottle, make powder of the present invention.

Claims (6)

1. the Chinese medicine composition for the nursing for treating infantile diarrhea, is characterized in that being made by the raw material of Chinese medicine of following weight portion: Pericarpium Granati 6-10 part, Pericarpium Mali pumilae 6-10 part, Endothelium Corneum Gigeriae Galli 4-6 part, Flos Caryophylli 3-6 part, Herba Agrimoniae 0.2-1.2 part, Herba Portulacae 6-9 part, Rhizoma Atractylodis Macrocephalae 3-6 part.
2. the Chinese medicine composition for the nursing for treating infantile diarrhea as claimed in claim 1, is characterized in that being made by the raw material of Chinese medicine of following weight portion: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
3. the Chinese medicine composition for the nursing for treating infantile diarrhea as claimed in claim 1 or 2, it is characterized in that: the raw material of described Chinese medicine composition also comprises pharmaceutically acceptable adjuvant.
4. the Chinese medicine composition for the nursing for treating infantile diarrhea as claimed in claim 3 is characterized in that: described pharmaceutically acceptable adjuvant is glucose powder and edible or medicinal essence.
5. the Chinese medicine composition for the nursing for treating infantile diarrhea as claimed in claim 1 or 2, it is characterized in that: described Chinese medicine composition is tablet, pill, powder or capsule.
6. the Chinese medicine composition for the nursing for treating infantile diarrhea as claimed in claim 5, it is characterized in that: described Chinese medicine composition is powder.
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