CN104984237A - Traditional Chinese medicine composition and preparation method - Google Patents

Traditional Chinese medicine composition and preparation method Download PDF

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CN104984237A
CN104984237A CN201510375951.1A CN201510375951A CN104984237A CN 104984237 A CN104984237 A CN 104984237A CN 201510375951 A CN201510375951 A CN 201510375951A CN 104984237 A CN104984237 A CN 104984237A
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parts
radix
rhizoma
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chinese medicine
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吴联凯
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吴联凯
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Abstract

A traditional Chinese medicine composition comprises the following raw materials: 4 to 40 parts of Chinese angelica, 5 to 50 parts of parched white peony root, 3 to 30 parts of radix bupleuri, 4 to 40 parts of nutgrass galingale rhizome, 4 to 40 parts of curcuma aromatica, 4 to 40 parts of cortex albiziae, 5 to 50 parts of radix astragali preparata, 4 to 40 parts of roasted rhizoma atractylodis macrocephalae, 3 to 30 parts of cassia twig, 3 to 30 parts of coptis chinensis, 1 to 10 parts of baked fructus evodiae, 5 to 50 parts of calcined concha arcae, 5 to 50 parts of cuttlebone, 4 to 40 parts of fritillary bulb, 5 to 50 parts of clamshell, 4 to 40 parts of immature bitter oranges, 4 to 40 parts of officinal magnolia bark, 4 to 40 parts of fried radish seeds, 3 to 30 parts of pinellia ternata, 3 to 30 parts of melia toosendan, 3 to 30 parts of corydalis tuber, and 3 to 30 parts of baked licorice.

Description

A kind of Chinese medicine composition and preparation method thereof
Technical field
The present invention relates to field of traditional Chinese, particularly a kind of Chinese medicine composition and preparation method thereof.
Background technology
Hyperchlorhydria belongs to the acid regurgitation category of Chinese medicine, and acid regurgitation refers to the symptom of general acid regurgitation water, and the lighter claims pantothenic acid; All sour waters, by upper general in stomach, if do not swallow person to be at random called acid regurgitation, are not swallowed and the person of spuing is referred to as acid regurgitation.Hyperchlorhydria has three large symptoms:
One, acid regurgitation
Acid regurgitation refers to that gastric content reaches pars oralis pharyngis through esophageal reflux, and oral sensation is to occurring acidic materials, and it and duodenum content reach pars oralis pharyngis through stomach, esophageal reflux, and oral sensation, to there is bitter substance, is referred to as reflux.Symptom caused by acid regurgitation and harm can have 1. heartburn; 2. esophagodynia; 3. odynophagia; 4. dysphagia; 5. respiratory symptom.
The difference of acid regurgitation and vomiting is, the simultaneous phenomenon that the former does not feel sick and retches.Acid regurgitation and the difference of ruminating are, the food reflux of absorption is not independently also chewed to oral cavity or is swallowed (usually occur in the half an hour after dining, see the Healthy People of hasty feed abundance of food or serious mental disease patient) again by the latter subsequently again.
Two, heartburn
Heartburn is a kind of pain of burning sample being positioned at epigastrium or pectus, simultaneously with the symptom of acid regurgitation.Heartburn be the modal symptom of digestive system one of, for majority, modal reason is too fast or too much owing to taking food, but, even if some people's exactissima diligentia diet also often has heartburn, also have some on the feed after some specific food as: there is heartburn phenomenon in wine, Fructus Capsici etc., these foods can make the lax or gastric acid secretion of Lower esophageal ephincter increase, and these two kinds of reasons above can cause heartburn.
Three, heart-burn
Gastroxia or gastric mucosa increase the sensitivity of acid and cause, and this symptom is comparatively common in functional dyspepsia, reflux esophagitis, gastric and duodenal ulcers and chronic gastritis.
Acid regurgitation is not an independent disease in Chinese medicine, has more among present gastropathy.The traditional Chinese medical science thinks that hyperchlorhydria is many by deficiency of stomach-Yin, and caused by syndrome of liver-stomach heat, consumption of body fluid caused by febrile disease, cruelly tells and rush down greatly, the pent-up of feelings will, and addicted to food, pungent savoury all easily hyperchlorhydria symptom occurs.Take to let out liver stomach function regulating in clinical, dispersing the stagnated pathogen with pungent drugs and lowering the adverse QI with bitter drugs is principle for the treatment of.
Summary of the invention
The invention provides a kind of Chinese medicine composition and preparation method thereof.This Chinese medicine composition is made up of Radix Angelicae Sinensis, Radix Paeoniae Alba (parched), Radix Bupleuri, Rhizoma Cyperi, Radix Curcumae, Cortex Albiziae, Radix Astragali Mongolici (processed), Rhizoma Atractylodis Macrocephalae (parched), Ramulus Cinnamomi, Rhizoma Coptidis, moxibustion Fructus Evodiae, Concha Arcae (calcined), Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Concha Meretricis Seu Cyclinae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Semen Raphani (parched), the Rhizoma Pinelliae, Fructus Toosendan, Rhizoma Corydalis, Radix Glycyrrhizae Preparata, there is obvious potentiation, effectively can treat hyperchlorhydria, and without obvious toxic and side effects, safety is high.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of Chinese medicine composition, with parts by weight, be made up of following raw material:
Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part.
China's TCM Culture is of long standing and well established, of extensive knowledge and profound scholarship, and the compatibility of Chinese medicine is particular about mutual reinforcement between, the mutual-assistance, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, contrary.Mutual reinforcement between, the compatibility of drugs that namely performance effects is similar uses can strengthen certain or several response to treatment, strengthens therapeutical effect; The mutual-assistance, in performance effects, namely have the medicine fit applications of certain general character, and based on a kind of medicine, another kind of medicine is auxiliary, can improve the curative effect of principal agent thing; Mutual restraint between two drugs, the mutual inhibitory action namely between medicine, drug toxicity or side effect can be cut down by another kind of medicine; The mutual-detoxication, namely a kind of medicine can alleviate or eliminate toxicity or the side effect of another kind of medicine; The mutual inhibition, i.e. two kinds of drug combinations, a kind of medicine and another medicine act on mutually and cause original effect and reduce, and even lose drug effect; On the contrary, namely refer to two kinds of drug combinations, toxicity or side effect may be produced.Owing to there is different compatibility relationships between different Chinese medicine, therefore when the above Chinese medicine of use two taste, must be allowed a choice, give full play to the compatibility relationship of the mutual reinforcement between mutual-assistance between medicine.
The present invention, by by 22 taste drug matchings, has jointly played the effect for the treatment of hyperchlorhydria, has had obvious potentiation, give full play to the compatibility effect of the mutual reinforcement between mutual-assistance, effectively can treat hyperchlorhydria between medicine.Introduce effect of each taste Chinese medicine below respectively, cure mainly disease and side's solution:
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The Radix Paeoniae Alba: nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Radix Bupleuri: evacuate and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Rhizoma Cyperi: dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
Radix Curcumae: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, distending pain of the breast, calentura coma, epilepsy is gone mad, and heat in blood tells nosebleed, jaundice dark coloured urine.
Cortex Albiziae: resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess, skin ulcer swells, and falls and flutters the pain of injury.
Radix Astragali Mongolici (processed): QI invigorating invigorating middle warmer.Weak for the deficiency of vital energy, anorexia and loose stool.
Rhizoma Atractylodis Macrocephalae (parched): invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, making the adverse-rising QI downwards.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Fructus Evodiae: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, gastral cavity abdomen hypochondriac pain, vomiting acid regurgitation, Diarrhoea.
Concha Arcae: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.Cementing for pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula , mass in the abdomen mass in the abdomen, stomachache pantothenic acid.
Endoconcha Sepiae: astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.For hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.
Bulbus Fritillariae Thunbergii: clearing heat, eliminating phlegm, relieving cough, detoxicating and resolving stagnation of pathogens eliminating carbuncle.For cough due to pathogenic wind-heat, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Concha Meretricis Seu Cyclinae: removing heat-phlegm, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, external removing dampness sore.For phlegm-fire cough, pain in chest and hypochondrium, sputum mixed with blood, scrofula goiter, stomachache acid regurgitation; External treatment eczema, scalds.
Fructus Aurantii Immaturus: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, visceroptosis.
Cortex Magnoliae Officinalis: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Semen Raphani: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Fructus Toosendan: soothing the liverly to expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing.For pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.
Rhizoma Corydalis: invigorate blood circulation, circulation of qi promoting, pain relieving.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Glycyrrhizae Preparata: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Fang Xie: we institute for symptom be heartburn, acid regurgitation, after breastbone or gastral cavilty portion pain, often shows effect because of emotional factors, epigastric distension and distress, and connect and two sides of body, sighing frequently, belch again and again, is defecated not smooth; Light red tongue, white and thin fur, stringy pulse.We's main separation Concha Arcae (calcined), Endoconcha Sepiae, Concha Meretricis Seu Cyclinae, Rhizoma Atractylodis Macrocephalae (parched) are monarch, invigorating the spleen and benefiting QI, dampness diuretic, relieving gastric hyperacidity to alleviate stomachache; With Radix Astragali Mongolici (processed), Radix Paeoniae Alba (parched), Radix Bupleuri, Rhizoma Cyperi, Rhizoma Coptidis, Fructus Toosendan dispersing the stagnated live-QI to relieve the stagnation of QI, it is ministerial drug; With Radix Angelicae Sinensis, Radix Curcumae, Cortex Albiziae, the Radix Astragali, Fructus Evodiae, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Semen Raphani (parched), the Rhizoma Pinelliae, Fructus Toosendan, Rhizoma Corydalis, Radix Glycyrrhizae Preparata for adjuvant drug, circulation of qi promoting, invigorate blood circulation, pain relieving, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Radix Glycyrrhizae is held concurrently and adjusts all medicines, also for making the use of medicine.
In order to make the compatibility of Chinese medicine composition provided by the invention play potentiation, as preferably, with parts by weight, raw material comprises Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part.
In order to make the compatibility of Chinese medicine composition provided by the invention play the best use of, in embodiments more provided by the invention, with parts by weight, raw material comprises Radix Angelicae Sinensis 12 parts; Radix Paeoniae Alba (parched) 15 parts; Radix Bupleuri 9 parts; Rhizoma Cyperi 12 parts; Radix Curcumae 12 parts; Cortex Albiziae 12 parts; Radix Astragali Mongolici (processed) 15 parts; Rhizoma Atractylodis Macrocephalae (parched) 12 parts; Ramulus Cinnamomi 9 parts; Rhizoma Coptidis 9 parts; Moxibustion Fructus Evodiae 3 parts; Concha Arcae (calcined) 15 parts; Endoconcha Sepiae 15 parts; Bulbus Fritillariae Thunbergii 12 parts; Concha Meretricis Seu Cyclinae 15 parts; Fructus Aurantii Immaturus 12 parts; Cortex Magnoliae Officinalis 12 parts; Semen Raphani (parched) 12 parts; The Rhizoma Pinelliae 9 parts; Fructus Toosendan 10 parts; Rhizoma Corydalis 10 parts; Radix Glycyrrhizae Preparata 9 parts.
Present invention also offers the application of Chinese medicine composition provided by the invention in preparation treatment hyperchlorhydria medicine.
In the application that the invention provides preparation treatment hyperchlorhydria medicine, with parts by weight, Chinese medicine composition provided by the invention is by Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part is made;
As preferably, the raw material of Chinese medicine composition provided by the invention comprises Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part;
Preferably, raw material comprises Radix Angelicae Sinensis 12 parts; Radix Paeoniae Alba (parched) 15 parts; Radix Bupleuri 9 parts; Rhizoma Cyperi 12 parts; Radix Curcumae 12 parts; Cortex Albiziae 12 parts; Radix Astragali Mongolici (processed) 15 parts; Rhizoma Atractylodis Macrocephalae (parched) 12 parts; Ramulus Cinnamomi 9 parts; Rhizoma Coptidis 9 parts; Moxibustion Fructus Evodiae 3 parts; Concha Arcae (calcined) 15 parts; Endoconcha Sepiae 15 parts; Bulbus Fritillariae Thunbergii 12 parts; Concha Meretricis Seu Cyclinae 15 parts; Fructus Aurantii Immaturus 12 parts; Cortex Magnoliae Officinalis 12 parts; Semen Raphani (parched) 12 parts; The Rhizoma Pinelliae 9 parts; Fructus Toosendan 10 parts; Rhizoma Corydalis 10 parts; Radix Glycyrrhizae Preparata 9 parts.
Present invention also offers a kind of preparation method of Chinese medicine composition, with parts by weight, raw material comprises Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part, gets raw material mixing, through water extraction, precipitate with ethanol, drying, to obtain final product.
In preparation method provided by the invention, in order to make the compatibility of Chinese medicine composition provided by the invention play potentiation, as preferably, with parts by weight, raw material comprises Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part;
In preparation method provided by the invention, in order to make the compatibility of Chinese medicine composition provided by the invention play optimum efficiency, in some embodiments provided of the present invention, with parts by weight, raw material comprises Radix Angelicae Sinensis 12 parts; Radix Paeoniae Alba (parched) 15 parts; Radix Bupleuri 9 parts; Rhizoma Cyperi 12 parts; Radix Curcumae 12 parts; Cortex Albiziae 12 parts; Radix Astragali Mongolici (processed) 15 parts; Rhizoma Atractylodis Macrocephalae (parched) 12 parts; Ramulus Cinnamomi 9 parts; Rhizoma Coptidis 9 parts; Moxibustion Fructus Evodiae 3 parts; Concha Arcae (calcined) 15 parts; Endoconcha Sepiae 15 parts; Bulbus Fritillariae Thunbergii 12 parts; Concha Meretricis Seu Cyclinae 15 parts; Fructus Aurantii Immaturus 12 parts; Cortex Magnoliae Officinalis 12 parts; Semen Raphani (parched) 12 parts; The Rhizoma Pinelliae 9 parts; Fructus Toosendan 10 parts; Rhizoma Corydalis 10 parts; Radix Glycyrrhizae Preparata 9 parts.
In preparation method provided by the invention, as preferably, water extraction is specially: decoct with water 2-4 time, and obtain Decoction, being concentrated into relative density is 1.2-1.3(65 ~ 75 DEG C), obtain extractum.
In the water extraction operation of preparation method provided by the invention, the number of times decocted with water is preferably 3 times, and the concrete operation step decocting with water 3 times is as follows:
Step one: add the first use water, first decocts 2h, isolates the first decoction liquor, remaining first medicinal residues, and the mass ratio of the first use water and raw material is (8-10): 1;
Step 2: get the first medicinal residues and mix with water with second, second decocts 1.5h, isolates the second fried liquid, remaining second medicinal residues, and the mass ratio of the second use water and raw material is (6-8): 1;
Step 3: get the second medicinal residues and mix with water with the 3rd, second decocts 1h, isolates the 3rd fried liquid, and the mass ratio of the 3rd use water and raw material is (3-5): 1;
Step 4: merge the first fried liquid, the second fried liquid and the 3rd fried liquid.
Relative density after Decoction concentrates plays key effect to the extraction of effective ingredient in Chinese medicine, if the relative density of the concentrated solution of Decoction is too small, because concentrated solution is rarer, the precipitation of formation is not easily coalescent, is difficult to sink, and waste ethanol; If relative density is excessive, Decoction, because of long-time decocting and concentrating, easily makes effective ingredient be destroyed, and causes starch gelatinization, form bulk, comprise the effective ingredient in Chinese medicine during precipitate with ethanol.Therefore in order to both ensure the magazine aggregate and precipitate in Chinese medicine, can ensure that again effective ingredient is not destroyed, the effective ingredient in Chinese medicine is fully dissolved in ethanol.In embodiments more provided by the invention, Decoction, is concentrated into relative density 1.2-1.3(65 ~ 75 DEG C)
In preparation method provided by the invention, as preferably, the Decoction that water extraction obtains is concentrated into relative density 1.25(72 DEG C)
In preparation method provided by the invention, in embodiments more provided by the invention, precipitate with ethanol is specially: add ethanol, leaves standstill, gets supernatant, removes ethanol, obtains refined liquid.
The step of precipitate with ethanol in preparation method provided by the invention, the concentration of ethanol and the mixed ethanol of extractum is vital for the impurity in effective removing extractum.In order to effectively remove the impurity in extractum, in some embodiments provided in the present invention, the mass ratio of ethanol and extractum is (5 ~ 6): 1.
The step of precipitate with ethanol in preparation method provided by the invention, the concentration of ethanol is also one of key factor for the effect of precipitate with ethanol.The concentration of ethanol is too low, and ethanol consumption is large, causes waste, reclaims inconvenient.And the precipitation formed is cotton-shaped, be difficult to sink, the effect of precipitate with ethanol is poor; The excessive concentration of ethanol, the alcohol extraction refined liquid obtained is less, and containing a large amount of active substance in precipitation, and high concentration ethanol easily causes local concentration too high, forms bulk precipitation, is wrapped up by effective ingredient, with precipitation removing, causes the loss of effective ingredient.In order to both ensure to have good precipitate with ethanol effect, ensure that again refined liquid contains effective ingredient as much as possible, in embodiments more provided by the invention, the mass percent concentration of ethanol is preferably 60% ~ 75%.
In order to guarantee to obtain good precipitate with ethanol effect, in embodiments more provided by the invention, time of repose is 14 ~ 16h.
As preferably, quiescent time is 15h.
The present invention also provides a kind of Chinese medicine composition obtained by preparation method provided by the invention.
The present invention also provides a kind of Chinese medicine preparation, is made up of Chinese medicine composition provided by the invention and medically acceptable adjuvant.
In Chinese medicine preparation provided by the invention, Chinese medicine composition provided by the invention, with parts by weight, raw material comprises Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part; As preferably, with parts by weight, raw material comprises Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part; In embodiments more provided by the invention, with parts by weight, raw material comprises Radix Angelicae Sinensis 12 parts; Radix Paeoniae Alba (parched) 15 parts; Radix Bupleuri 9 parts; Rhizoma Cyperi 12 parts; Radix Curcumae 12 parts; Cortex Albiziae 12 parts; Radix Astragali Mongolici (processed) 15 parts; Rhizoma Atractylodis Macrocephalae (parched) 12 parts; Ramulus Cinnamomi 9 parts; Rhizoma Coptidis 9 parts; Moxibustion Fructus Evodiae 3 parts; Concha Arcae (calcined) 15 parts; Endoconcha Sepiae 15 parts; Bulbus Fritillariae Thunbergii 12 parts; Concha Meretricis Seu Cyclinae 15 parts; Fructus Aurantii Immaturus 12 parts; Cortex Magnoliae Officinalis 12 parts; Semen Raphani (parched) 12 parts; The Rhizoma Pinelliae 9 parts; Fructus Toosendan 10 parts; Rhizoma Corydalis 10 parts; Radix Glycyrrhizae Preparata 9 parts; The preparation method of this Chinese medicine composition is: with parts by weight, and raw material comprises Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part, gets raw material mixing, through water extraction, precipitate with ethanol, drying, to obtain final product; As preferably, with parts by weight, raw material comprises Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part; In embodiments more provided by the invention, with parts by weight, raw material comprises Radix Angelicae Sinensis 12 parts; Radix Paeoniae Alba (parched) 15 parts; Radix Bupleuri 9 parts; Rhizoma Cyperi 12 parts; Radix Curcumae 12 parts; Cortex Albiziae 12 parts; Radix Astragali Mongolici (processed) 15 parts; Rhizoma Atractylodis Macrocephalae (parched) 12 parts; Ramulus Cinnamomi 9 parts; Rhizoma Coptidis 9 parts; Moxibustion Fructus Evodiae 3 parts; Concha Arcae (calcined) 15 parts; Endoconcha Sepiae 15 parts; Bulbus Fritillariae Thunbergii 12 parts; Concha Meretricis Seu Cyclinae 15 parts; Fructus Aurantii Immaturus 12 parts; Cortex Magnoliae Officinalis 12 parts; Semen Raphani (parched) 12 parts; The Rhizoma Pinelliae 9 parts; Fructus Toosendan 10 parts; Rhizoma Corydalis 10 parts; Radix Glycyrrhizae Preparata 9 parts; Water extraction is specially: decoct with water 2-4 time, and obtain Decoction, being concentrated into relative density is 1.2-1.3(65 ~ 75 DEG C), obtain extractum; In the water extraction operation of preparation method provided by the invention, the number of times decocted with water is preferably 3 times, the concrete operation step decocting with water 3 times is as follows: step one: add first and use water, first decocts 2h, isolate the first decoction liquor, remaining first medicinal residues, the mass ratio of the first use water and raw material is (8-10): 1; Step 2: get the first medicinal residues and mix with water with second, second decocts 1.5h, isolates the second fried liquid, remaining second medicinal residues, and the mass ratio of the second use water and raw material is (6-8): 1; Step 3: get the second medicinal residues and mix with water with the 3rd, second decocts 1h, isolates the 3rd fried liquid, and the mass ratio of the 3rd use water and raw material is (3-5): 1; Step 4: merge the first fried liquid, the second fried liquid and the 3rd fried liquid; In embodiments more provided by the invention, Decoction, is concentrated into relative density 1.2-1.3(65 ~ 75 DEG C); As preferably, the Decoction that water extraction obtains is concentrated into relative density 1.25(72 DEG C); Precipitate with ethanol is specially: add ethanol, leaves standstill, gets supernatant, removes ethanol, obtains refined liquid; The mass ratio of ethanol and extractum is (5 ~ 6): 1; The mass percent concentration of ethanol is preferably 60% ~ 75%; Time of repose is 14 ~ 16h, is preferably 15h.
As preferably, the dosage form of Chinese medicine preparation is granule, capsule, tablet, medicinal tea, oral liquid or drop pill.
In Chinese medicine preparation provided by the invention; pharmaceutically acceptable adjuvant is the customary adjuvant in pharmaceutical preparation; as disintegrating agent, lubricant, binding agent etc.; but acceptable adjuvant is not limited thereto on Chinese materia medica of the present invention; those skilled in the art think that feasible customary adjuvant is all within protection scope of the present invention, and the present invention does not limit at this.
In the present invention, the preparation method of Chinese medicine preparation is conventional preparation method.In the present invention; Chinese medicine composition provided by the invention is mixed with the pharmaceutically acceptable adjuvant needed for different dosage form; routine techniques is utilized to make conventional oral formulations; those skilled in the art think that feasible preparation method is all within protection scope of the present invention, and the present invention does not limit at this.
The invention provides a kind of Chinese medicine composition and preparation method thereof.This Chinese medicine composition, with parts by weight, by Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part is made.
Detailed description of the invention
The invention discloses a kind of Chinese medicine composition and preparation method thereof, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 Chinese medicine composition
Get Radix Angelicae Sinensis 12g, Radix Paeoniae Alba (parched) 15g, Radix Bupleuri 9g, Rhizoma Cyperi 12 g, Radix Curcumae 12 g, Cortex Albiziae 12 g, Radix Astragali Mongolici (processed) 15 g, Rhizoma Atractylodis Macrocephalae (parched) 12 g, Ramulus Cinnamomi 9 g, Rhizoma Coptidis 9 g, moxibustion Fructus Evodiae 3 g, Concha Arcae (calcined) 15 g, Endoconcha Sepiae 15 g, Bulbus Fritillariae Thunbergii 12 g, Concha Meretricis Seu Cyclinae 15 g, Fructus Aurantii Immaturus 12 g, Cortex Magnoliae Officinalis 12 g, Semen Raphani (parched) 12 g, the Rhizoma Pinelliae 9 g, Fructus Toosendan 10 g, Rhizoma Corydalis 10 g, Radix Glycyrrhizae Preparata 9 g mix homogeneously, decoct with water 3 times, first time adds 2200g water, decoct 2h, isolate fried liquid; Second time adds 1700g water, decocts 1.5h, isolates fried liquid; Third time adds 1000g water, decocts 1h, merges the fried liquid decocted for three times, obtains Decoction.Decoction is concentrated into relative density 1.25(72 DEG C), obtain extractum 500g.
Get above-mentioned extractum, add the ethanol water of 2500g 60%, mix homogeneously, under 15 ± 5 DEG C of conditions, leave standstill 15h; Remove supernatant, reclaim ethanol extremely without alcohol taste, spraying dry, to obtain final product.
The preparation of embodiment 2 Chinese medicine composition
Get Radix Angelicae Sinensis 4g, Radix Paeoniae Alba (parched) 15g, Radix Bupleuri 3g, Rhizoma Cyperi 4 g, Radix Curcumae 4g, Cortex Albiziae 4 g, Radix Astragali Mongolici (processed) 15 g, Rhizoma Atractylodis Macrocephalae (parched) 4 g, Ramulus Cinnamomi 3g, Rhizoma Coptidis 3 g, moxibustion Fructus Evodiae 1g, Concha Arcae (calcined) 15 g, Endoconcha Sepiae 15 g, Bulbus Fritillariae Thunbergii 4g, Concha Meretricis Seu Cyclinae 15 g, Fructus Aurantii Immaturus 4g, Cortex Magnoliae Officinalis 4 g, Semen Raphani (parched) 4 g, the Rhizoma Pinelliae 3 g, Fructus Toosendan 3 g, Rhizoma Corydalis 3 g, Radix Glycyrrhizae Preparata 3 g mix homogeneously, decoct with water 3 times, first time adds 1100g water, decoct 2h, isolate fried liquid; Second time adds 900g water, decocts 1.5h, isolates fried liquid; Third time adds 500g water, decocts 1h, merges the fried liquid decocted for three times, obtains Decoction.Decoction is concentrated into relative density 1.25(72 DEG C), obtain extractum 200g.
Get above-mentioned extractum, add the ethanol water of 1000g 70%, mix homogeneously, under 15 ± 5 DEG C of conditions, leave standstill 15h; Remove supernatant, reclaim ethanol extremely without alcohol taste, spraying dry, to obtain final product.
The preparation of embodiment 3 Chinese medicine composition
Get Radix Angelicae Sinensis 40g, Radix Paeoniae Alba (parched) 50g, Radix Bupleuri 30g, Rhizoma Cyperi 40g, Radix Curcumae 40g, Cortex Albiziae 40 g, Radix Astragali Mongolici (processed) 50 g, Rhizoma Atractylodis Macrocephalae (parched) 40 g, Ramulus Cinnamomi 30g, Rhizoma Coptidis 30g, moxibustion Fructus Evodiae 10g, Concha Arcae (calcined) 50g, Endoconcha Sepiae 50g, Bulbus Fritillariae Thunbergii 40g, Concha Meretricis Seu Cyclinae 50g, Fructus Aurantii Immaturus 40g, Cortex Magnoliae Officinalis 40g, Semen Raphani (parched) 40g, Rhizoma Pinelliae 30g, Fructus Toosendan 30g, Rhizoma Corydalis 30g, Radix Glycyrrhizae Preparata 30g mix homogeneously, decoct with water 3 times, first time adds 7000g water, decoct 2h, isolate fried liquid; Second time adds 5000g water, decocts 1.5h, isolates fried liquid; Third time adds 3000g water, decocts 1h, merges the fried liquid decocted for three times, obtains Decoction.Decoction is concentrated into relative density 1.25(72 DEG C), obtain extractum 1400g.
Get above-mentioned extractum, add the ethanol water of 7000g 75%, mix homogeneously, under 15 ± 5 DEG C of conditions, leave standstill 15h; Remove supernatant, reclaim ethanol extremely without alcohol taste, spraying dry, to obtain final product.
The evaluation of clinical curative effect of embodiment 4 Chinese medicine composition:
The standard of curative effect evaluation is:
1. effective: symptom all disappears, appetite is normal, without malaise symptoms;
2. effective: cardinal symptom disappears, there are the symptoms such as uncomfortable in chest, belch after overwork and anger;
3. invalid: symptom is without improvement.
By clinical trial, therapeutic outcome is: clinical treatment hyperchlorhydria patient 50 example, taking granule of the present invention, once a bag (10 grams), take three day, 7 days is a course for the treatment of.Through a course of therapy, effective 37 examples, account for 74%; Effective 12 examples, account for 24%; Invalid 1 example, accounts for 2%.Total effective rate is 98%.
For showing that this Chinese medicine composition has obvious potentiation, the Chinese medicine composition provided for embodiment 1, replaces with Concha Ostreae by Concha Arcae (calcined), Radix Bupleuri is replaced with Flos Rosae Chinensis, and the Rhizoma Pinelliae is replaced with Folium Eriobotryae, and as a control group 1; Concha Arcae (calcined) only in Example 1, Endoconcha Sepiae, Concha Meretricis Seu Cyclinae, Rhizoma Atractylodis Macrocephalae (parched), Radix Bupleuri, Fructus Evodiae, Radix Glycyrrhizae Preparata are matched group 2.By evaluating the curative effect of each group, and calculating total effective rate (total effective rate=obvious effective rate+effective percentage), obtaining result as table 1.
Table 1 Chinese Herbs evaluation result
From above-mentioned result of the test, the traditional Chinese medicine composition for treating Be very effective that embodiment 1 provides, higher than matched group 1 and matched group 2, shows that this Chinese medicine composition has obvious potentiation, effectively can treat hyperchlorhydria.
In the whole course for the treatment of, do not find that untoward reaction appears in patient, show that this Chinese medicine composition is without obvious toxic and side effects, safety is high.
The Chinese medicine composition that Example 2,3 is obtained, evaluation of clinical curative effect is carried out according to above-mentioned clinical effect trial method and standard, the curative effect of the Chinese medicine composition that result and embodiment 1 obtain is close, show that the Chinese medicine composition that embodiment 1-3 obtains has obvious potentiation equally, can effective prevention and therapy hyperchlorhydria, and without obvious toxic and side effects, safety is high.
As can be seen here, Chinese medicine composition provided by the invention has obvious potentiation, can effective prevention and therapy hyperchlorhydria, and without obvious toxic and side effects, safety is high.
The preparation of embodiment 5 Chinese medicine granules
The Chinese medicine composition that Example 1 obtains mixes with customary adjuvant, conventionally prepares Chinese medicine granules.
The preparation of embodiment 6 Chinese medicine capsules
The Chinese medicine composition that Example 2 obtains mixes with customary adjuvant, conventionally prepares Chinese medicine capsules.
The preparation of embodiment 7 Chinese medicinal tablet
The Chinese medicine composition that Example 3 obtains mixes with customary adjuvant, conventionally prepares Chinese medicinal tablet.
The preparation of embodiment 8 traditional Chinese medicine tea
The Chinese medicine composition that Example 1 obtains mixes with customary adjuvant, conventionally prepares traditional Chinese medicine tea.
The preparation of embodiment 9 Chinese medicine oral liquid
The Chinese medicine composition that Example 1 obtains mixes with customary adjuvant, conventionally prepares extract oral agent.
The preparation of embodiment 10 Traditional Chinese Medicine Dropping Pill
The Chinese medicine composition that Example 1 obtains mixes with customary adjuvant, conventionally prepares Traditional Chinese Medicine Dropping Pill.
The preparation of embodiment 11 Chinese medicine granules
The Chinese medicine composition that Example 3 obtains mixes with customary adjuvant, conventionally prepares Chinese medicine granules.
The above is only the preferred embodiment for the present invention; it should be pointed out that for this technology those of ordinary skill in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims (10)

1. a Chinese medicine composition, is characterized in that, with parts by weight, is made up of following raw material:
Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part.
2. Chinese medicine composition according to claim 1, is characterized in that, with parts by weight, is made up of following raw material:
Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part.
3. the application of Chinese medicine composition according to claim 1 and 2 in preparation treatment hyperchlorhydria medicine.
4. the preparation method of a kind of Chinese medicine composition according to claim 1 and 2, is characterized in that, with parts by weight, raw material comprises Radix Angelicae Sinensis 4-40 part; Radix Paeoniae Alba (parched) 5-50 part; Radix Bupleuri 3-30 part; Rhizoma Cyperi 4-40 part; Radix Curcumae 4-40 part; Cortex Albiziae 4-40 part; Radix Astragali Mongolici (processed) 5-50 part; Rhizoma Atractylodis Macrocephalae (parched) 4-40 part; Ramulus Cinnamomi 3-30 part; Rhizoma Coptidis 3-30 part; Moxibustion Fructus Evodiae 1-10 part; Concha Arcae (calcined) 5-50 part; Endoconcha Sepiae 5-50 part; Bulbus Fritillariae Thunbergii 4-40 part; Concha Meretricis Seu Cyclinae 5-50 part; Fructus Aurantii Immaturus 4-40 part; Cortex Magnoliae Officinalis 4-40 part; Semen Raphani (parched) 4-40 part; Rhizoma Pinelliae 3-30 part; Fructus Toosendan 3-30 part; Rhizoma Corydalis 3-30 part; Radix Glycyrrhizae Preparata 3-30 part, described in it, raw material mixing, through water extraction, precipitate with ethanol, drying, to obtain final product.
5. preparation method according to claim 4, is characterized in that, with parts by weight, is made up of following raw material: Radix Angelicae Sinensis 8-35 part; Radix Paeoniae Alba (parched) 10-45 part; Radix Bupleuri 5-25 part; Rhizoma Cyperi 8-35 part; Radix Curcumae 8-35 part; Cortex Albiziae 8-35 part; Radix Astragali Mongolici (processed) 10-45 part; Rhizoma Atractylodis Macrocephalae (parched) 8-35 part; Ramulus Cinnamomi 5-25 part; Rhizoma Coptidis 5-25 part; Moxibustion Fructus Evodiae 3-8 part; Concha Arcae (calcined) 10-45 part; Endoconcha Sepiae 10-45 part; Bulbus Fritillariae Thunbergii 8-35 part; Concha Meretricis Seu Cyclinae 10-45 part; Fructus Aurantii Immaturus 8-35 part; Cortex Magnoliae Officinalis 8-35 part; Semen Raphani (parched) 8-35 part; Rhizoma Pinelliae 5-25 part; Fructus Toosendan 5-25 part; Rhizoma Corydalis 5-25 part; Radix Glycyrrhizae Preparata 5-25 part.
6. preparation method according to claim 4, is characterized in that, described water extraction is specially: decoct with water 2-4 time, obtains Decoction, and to be concentrated into relative density be 1.2-1.3(temperature is 65 ~ 75 DEG C), obtain extractum.
7. preparation method according to claim 4, is characterized in that, described precipitate with ethanol is specially: add ethanol, leaves standstill, gets supernatant, removes ethanol, obtains refined liquid.
8. the Chinese medicine composition that the preparation method according to any one of claim 4 to 7 is obtained.
9. a Chinese medicine preparation, is characterized in that, is made up of the Chinese medicine composition as described in claim 1,2 or 8 and pharmaceutically acceptable adjuvant.
10. Chinese medicine preparation according to claim 9, is characterized in that, the dosage form of described Chinese medicine preparation is granule, capsule, tablet, medicinal tea, oral liquid or drop pill.
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CN105920112A (en) * 2016-06-07 2016-09-07 浙江省中医院 Traditional Chinese medicine composition and application thereof

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Application publication date: 20151021