CN103690919A - Medicine for treating piglet iron-deficiency anemia and preparation method of medicine - Google Patents

Medicine for treating piglet iron-deficiency anemia and preparation method of medicine Download PDF

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CN103690919A
CN103690919A CN201310718911.3A CN201310718911A CN103690919A CN 103690919 A CN103690919 A CN 103690919A CN 201310718911 A CN201310718911 A CN 201310718911A CN 103690919 A CN103690919 A CN 103690919A
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CN103690919B (en
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王艳
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Chongqing new hope feed Co., Ltd.
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Shandong New Hope Liuhe Group Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a medicine for treating piglet iron-deficiency anemia and a preparation method of the medicine. The medicine comprises the following raw material medicines: poria cocos, bighead atractylodes rhizome, Chinese angelica, ligusticum wallichii, scutellaria baicalensis, polygonum multiflorum, oriental wormwood, rhizoma atractylodis, astragalus, radix gentianae, liquorice, combretum indicum, polygala tenuifolia, codonopsis pilosula, radix ophiopogonis, fructus amomi, platycodon grandiflorum, elecampane, spina date seed and ginger. The medicine for treating piglet iron-deficiency anemia has the beneficial effects that the medicine has the treatment principle of supplementing iron, tonifying spleen, tonifying qi and promoting hematogenesis and has the advantages of high efficiency, small toxic and side effects, no residue, zero drug resistance, environment friendliness, capacity of increasing the immunity of human body, short course of treatment and no disease reoccurrence in the treatment of pigments suffering from the iron-deficiency anemia.

Description

Be used for the treatment of medicine of piglet iron deficiency anemia and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of piglet iron deficiency anemia and preparation method thereof.
Background technology
Piglet iron deficiency anemia, refers to a kind of nutritional anemia due to the suckling pig iron deficiency of 5～21 ages in days, is mainly in the autumn, winter, early spring, serious to the growth promoter harm of pig.Primary disease has mass-sending in some areas, due to iron deficiency or demand large and under-supply, affect the generation of hemoglobin in piglet body, erythrocytic quantity reduces, and iron deficiency anemia occurs.In addition, in sow and pig starter feed, lack cobalt, copper, protein etc. and also anemia can occur.The difference that lacks copper and ferrum is, during iron deficiency, content of hemoglobin reduces, and RBC number reduces while lacking copper.
Suckling pig anemia is commonly encountered diseases.Raw latter about 10 days of piglet, if do not obtain supplementing of ferrum from the external world, will there is iron deficiency anemia in time one length.Especially the piglet of cement or the stable breeding of masonry floor, few because contacting fresh soil chance, sickness rate is higher, can reach 40% left and right.
General ill piglet falls ill at 5～21 ages in days, and spirit is depressed, and peel off and lie prostrate, loss of appetite, malnutrition, skeletonize, ear vein does not appear.Visual mucosa is pale, slight xanthochromia.Contrary vertical by hair, accelerated breathing, palpitates quickly, and body temperature is not high.Because blood is thin and vascular wall degeneration, often occur that lower abdomen, lower jaw edema and Celom liquid loading increase.When gastrointestinal wall undernutrition causes dyssecretosis, there is again the gastricisms such as hyperchlorhydria or achlorhydria, dysentery, growth promoter is stagnated, and periodically there is dysentery and constipation in the piglet becoming thin.The piglet of another type loses and becomes thin, in appearance may be fatter, and growth promoter is very fast, during 2～4 week age, can although this disease mortality rate of sudden death is not high at the volley, but the dysplasia of affected pig long term growth, feed conversion rate is low, to pig industry, has brought serious economic loss.
Modern veterinary's theory is thought, suffer from iron deficiency anemia piglet skin and visual mucosa pale, muscle color is thin out, heart diffusion, liver enlargement and have steatosis, muscle pale red, blood is thinner, in splanchnocoel, may have liquid, pulmonary edema or generation inflammatory lesion, kidney parenchymatous degeneration, mortality rate is 15%～20%.
Although the feeding and management of in-pig and nursing sow, the daily ration of the rich in proteins of feeding, inorganic salt (ferrum, copper) and vitamin are strengthened in prevention.Antenatal 2 days of in-pig, to 1 month puerperal, daily iron supplement ferrous sulfate, made the feces that piglet can be rich in ferrum by the sow that searches for food supplement ferrum matter; Or in each 1 month, supplement the generation that hydrolyzed soybean protein chelated iron can effectively prevent piglet iron deficiency anemia before and after the sows farrowing, if of a specified duration but ferrous sulfate was placed in air, airborne oxygen can be oxidized to low price ferrum high price ferrum, after piglet takes, there will be the phenomenons such as diarrhoea, vomiting.
Chinese herbal medicine is the powerful mean of motherland's medical science disease preventing and treating, traditional Chinese veterinary medicine is cured the disease, from " organic conception " and " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", according to the viewpoint of " treatment must aim at the pathogenesis of disease ", the base therapy principles such as " vigorate qi and replenish the blood ", " blood-supplementing blood-nourishing " have been proposed, overcome Western medicine and too mechanically, solely acted on some links, and the more shortcoming of untoward reaction.
Chinese medicine contains a large amount of active skull cap components, can improve the hemopoietic function of body, strengthen premunition, compare with Western medicine, have that toxicity is low, side effect is little, residual low and body does not produce drug resistance and without unique advantages such as teratogenesis degeneration, aspect treatment piglet iron deficiency anemia, playing good curative effect.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of medicine that is used for the treatment of piglet iron deficiency anemia and preparation method thereof, adopt this medicine to piglet therapeutics of iron deficiency anemia have advantages of efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period and the state of an illness not repeatedly.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of piglet iron deficiency anemia, it is characterized in that, described medicine comprises following raw medicinal material: Poria, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Scutellariae, Radix Polygoni Multiflori, Herba Artemisiae Scopariae, Rhizoma Atractylodis, the Radix Astragali, Radix Gentianae, Radix Glycyrrhizae, Fructus Quisqualis, Radix Polygalae, Radix Codonopsis, Radix Ophiopogonis, Fructus Amomi, Radix Platycodonis, the Radix Aucklandiae, Semen Ziziphi Spinosae and Rhizoma Zingiberis Recens.
Described medicine is comprised of following raw medicinal material: Poria 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 15-25 weight portion, Radix Angelicae Sinensis 15-25 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Radix Scutellariae 10-30 weight portion, Radix Polygoni Multiflori 15-25 weight portion, Herba Artemisiae Scopariae 13-20 weight portion, Rhizoma Atractylodis 15-20 weight portion, Radix Astragali 10-30 weight portion, Radix Gentianae 15-30 weight portion, Radix Glycyrrhizae 15-20 weight portion, Fructus Quisqualis 12-28 weight portion, Radix Polygalae 15-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Ophiopogonis 15-30 weight portion, Fructus Amomi 10-20 weight portion, Radix Platycodonis 14-26 weight portion, Radix Aucklandiae 15-25 weight portion, Semen Ziziphi Spinosae 15-25 weight portion and Rhizoma Zingiberis Recens 10-20 weight portion.
Described medicine is comprised of following raw medicinal material: Poria 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 18-23 weight portion, Radix Angelicae Sinensis 18-20 weight portion, Rhizoma Chuanxiong 14-17 weight portion, Radix Scutellariae 15-20 weight portion, Radix Polygoni Multiflori 18-23 weight portion, Herba Artemisiae Scopariae 16-20 weight portion, Rhizoma Atractylodis 15-18 weight portion, Radix Astragali 15-25 weight portion, Radix Gentianae 20-25 weight portion, Radix Glycyrrhizae 15-18 weight portion, Fructus Quisqualis 18-23 weight portion, Radix Polygalae 17-20 weight portion, Radix Codonopsis 13-15 weight portion, Radix Ophiopogonis 18-24 weight portion, Fructus Amomi 13-16 weight portion, Radix Platycodonis 18-22 weight portion, Radix Aucklandiae 20-24 weight portion, Semen Ziziphi Spinosae 19-23 weight portion and Rhizoma Zingiberis Recens 13-17 weight portion.
Described medicine also comprises: Semen Nelumbinis, Rhizomadioscoreae, Radix Dipsaci, Pericarpium Citri Reticulatae and Fructus Crataegi.
Described medicine is comprised of the raw medicinal material of following parts by weight: Poria 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 15-25 weight portion, Radix Angelicae Sinensis 15-25 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Radix Scutellariae 10-30 weight portion, Radix Polygoni Multiflori 15-25 weight portion, Herba Artemisiae Scopariae 13-20 weight portion, Rhizoma Atractylodis 15-20 weight portion, Radix Astragali 10-30 weight portion, Radix Gentianae 15-30 weight portion, Radix Glycyrrhizae 15-20 weight portion, Fructus Quisqualis 12-28 weight portion, Radix Polygalae 15-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Ophiopogonis 15-30 weight portion, Fructus Amomi 10-20 weight portion, Radix Platycodonis 14-26 weight portion, Radix Aucklandiae 15-25 weight portion, Semen Ziziphi Spinosae 15-25 weight portion, Rhizoma Zingiberis Recens 10-20 weight portion, Semen Nelumbinis 10-20 weight portion, Rhizomadioscoreae 10-20 weight portion, Radix Dipsaci 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Poria 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 18-23 weight portion, Radix Angelicae Sinensis 18-20 weight portion, Rhizoma Chuanxiong 14-17 weight portion, Radix Scutellariae 15-20 weight portion, Radix Polygoni Multiflori 18-23 weight portion, Herba Artemisiae Scopariae 16-20 weight portion, Rhizoma Atractylodis 15-18 weight portion, Radix Astragali 15-25 weight portion, Radix Gentianae 20-25 weight portion, Radix Glycyrrhizae 15-18 weight portion, Fructus Quisqualis 18-23 weight portion, Radix Polygalae 17-20 weight portion, Radix Codonopsis 13-15 weight portion, Radix Ophiopogonis 18-24 weight portion, Fructus Amomi 13-16 weight portion, Radix Platycodonis 18-22 weight portion, Radix Aucklandiae 20-24 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Rhizoma Zingiberis Recens 13-17 weight portion, Semen Nelumbinis 15-20 weight portion, Rhizomadioscoreae 10-16 weight portion, Radix Dipsaci 10-15 weight portion, Pericarpium Citri Reticulatae 13-17 weight portion and Fructus Crataegi 13-18 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Poria 21 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Angelicae Sinensis 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Scutellariae 17 weight portions, Radix Polygoni Multiflori 21 weight portions, Herba Artemisiae Scopariae 18 weight portions, Rhizoma Atractylodis 17 weight portions, the Radix Astragali 20 weight portions, Radix Gentianae 23 weight portions, Radix Glycyrrhizae 17 weight portions, Fructus Quisqualis 20 weight portions, Radix Polygalae 18 weight portions, Radix Codonopsis 14 weight portions, Radix Ophiopogonis 21 weight portion, Fructus Amomi 15 weight portions, Radix Platycodonis 20 weight portions, the Radix Aucklandiae 22 weight portions, Semen Ziziphi Spinosae 21 weight portions, Rhizoma Zingiberis Recens 15 weight portions, Semen Nelumbinis 17 weight portions, Rhizomadioscoreae 13 weight portions, Radix Dipsaci 13 weight portions, Pericarpium Citri Reticulatae 15 weight portions and Fructus Crataegi 15 weight portions.
In order better to realize above-mentioned purpose, the invention provides the preparation method of the medicine that is used for the treatment of piglet iron deficiency anemia, described preparation method comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects by the raw material fine powder of 120 mesh sieves, and particulate matter remaining after sieving is standby;
B, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 5～7 times of amounts is 85%, each 1～2 hour, extracted twice liquid is merged standing, obtain extracting solution 1, medicinal residues are standby;
C, the medicinal residues that in step b, ethanol extraction is crossed are added to 5～7 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing, obtain extracting solution 2;
D, extracting solution 1 and extracting solution 2 merged, filter 1.38 filtrate when concentrating under reduced pressure relative density is 50 ℃～60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicated powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: it is Therapeutic Principle that iron supplement invigorating the spleen and benefiting QI hemopoietic is take in the present invention, to suffering from the treatment of the piglet of iron deficiency anemia, have advantages of efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period and the state of an illness not repeatedly.
The specific embodiment
The major lesions of piglet iron deficiency anemia at taste, kidney, relate to the heart, liver, ferrum is one of necessary trace element of newborn piglet growth promoter, is also the key component of hemoglobin in body, Myoglobin and institute's iron content enzyme.Although body iron-holder seldom, it plays vital effect in life, and iron deficiency can cause the generation of piglet iron deficiency anemia.Pig house structure and environmental factors: current pig house ground great majority be take cement and slabstone as main, add environmental condition restriction, and the space for activities of piglet is not enough, makes piglet be difficult to contact soil and obtain supplementing of exogenous ferrum; Feedstuff aspect: comprehensive sow gestation phase of feed nutrition or age of sucking, not comprehensive nutrition in feedstuff, lacks the trace element such as ferrum, copper, cobalt, makes iron content deficiency in breast milk; Feed formulation is fed for a long time containing calcareous too much feedstuff (as conch meal, bone meal, Paris white) or contains the absorption of tanning superacid feedstuff (Sorghum vulgare Pers., Testa Tritici etc.) and having affected ferrum unreasonable age of sucking, thereby has reduced the contents level of ferrum in breast milk; Piglet opens and ate late induction piglet to open food excessively slow, has greatly delayed piglet digestive organ's growth promoter and the raising of digesting and assimilating function, even by oral iron supplement, absorbtivity is also limited; Piglet oneself factor: to store ferrum amount during fetal development in liver few due to piglet, causes the reserves of ferrum in newborn piglet body less (general every kg body weight is iron content 28mg left and right only).Piglet maintains normal growth need consume ferrum 6 ~ 12mg every day, and after general piglet birth, can obtain 1mg ferrum at most every day from breast milk.Therefore, if newborn piglet iron supplement not in time, 3 ~ 4 days after birth will be by the 40 ~ 50mg iron loss in body to the greatest extent, thus there is iron deficiency anemia.
Chinese veterinarian is dialectical thinks that piglet iron deficiency anemia position is at taste kidney.Blood, blood, is the liquid that follows the polytrophic redness of row in arteries and veins, is form human body and maintain one of base substance of human life activity.Blood master, in the heart, is hidden in liver, unites in spleen, is distributed in lung, and root, in kidney, follows among row vascular regularly, in arteries and veins, operates and does not stop, and gives full play to and irrigates physiological effect all over the body.The most basic material of blood, therefore saying is meaning blood " (< < Ling Shu Miraculous Pivot or Divine Axis determine gas > >): " blood person essence-QI from water and grain is also ... though therefore the main blood spleen of heart stomach function regulating, blood is spontaneous " (< < married woman good recipe regulating menstruation door > >)." middle Jiao extracting juice of being bullied, changes and red blood stored in the liver is also all had under one's command in spleen, mend because the raw essence of water and grain of tasteization is the base substance that blood generates, so there are taste, be the saying of " source of generating QI and blood ".The quality of dietetic nutrition, the power of transformation and transportation of the spleen and stomach, directly shadow 9 is raw towards the change of blood." many self energys of lid diet hemopoietic, diet at least blood is not raw " (< < Principle and Prohibition for Medical profession asthenia opinion > >).Therefore, people's deficiency is taken the photograph in chronic dietary nutrition, or the transportation capabilities long-run disturbance of taste, and the generation that all can cause blood is not enough and form the pathological change of blood deficiency.The kidney being a water ZANG-organ, main store essential substances and change blood " (< < companion mountain hall class is distinguished blood > >)." institute of blood becomes also for kidney storing essence, smart person " (> > under < < General Treatise on the Cause and Symptoms of Diseases spleen fatiguing disease duke or princess under an emperor).By upper sight it, marrow is the base substance of being hemopoietic liquid also.In sum, essence of water and grain, ying-qi, body fluid, marrow are the material base that generates blood.But body fluid and ying-qi all come from the essence of water and grain that ingesta generates through digesting and assimilating of spleen stomach function regulating.So with regard to Material Source, essence of water and grain and marrow are the main matter bases that blood generates.The spleen being the foundation of acquired constitution, source of generating QI and blood.Taste are changed the base substance of raw being of essence of water and grain hemopoietic liquid." blood person foodstuff essence also.Come in a continuous stream, and growing directly from seeds is in spleen " (< < Jing Yue's complete work passes loyal record state of internal organs another matter > >)." clearing heat in QI system of water paddy in stomach, borrows the transporting of spleen to become blood, therefore say biochemical in spleen " (< < doctor rock blood > >).If middle burnt weakness of the spleen and stomach, inability of food and drink to be digested and transported is precise and tiny, and change source is not enough, often causes blood deficiency.Visible, Chinese medicine has recognized that the relation of blood and nutrient substance, also has recognized that spleen is a hemopoietic organ.Kidney storing essence, the raw marrow of essence.Marrow is the base substance of being hemopoietic liquid also, therefore there is the source of blood to be saying of kidney.The traditional Chinese medical science not only recognizes that bone marrow is hemopoietic organ, and kidney has regulating action to the generation of blood, and recognizes that kidney essense is that effect by liver generates blood, thus: " blood with gas; different name is similar, though have cereal essence and air minute, always by essence of water and grain instituteization.Its yet Hun Ran mono-district of beginning, does not divide pure and impurely, obtains the drum fortune of temper, as steamed in lung on mist, is gas; Gas does not consume, return be skillful in kidney and be essence; Essence is not let out, return be skillful in liver and change purify the blood " (< < Zhang Shi doctor logical all blood door > >).
In sum, blood is that to take essence of water and grain and marrow be main matter basis, under the combined effect of the internal organs such as taste, kidney and generate.Therefore conventional, nourish the blood of the heart, the method such as invigorating the heart and spleen, nourishing liver blood and kidney tonifying marrow facilitating to be to control the time of blood deficiency.
The mechanism of Chinese herb prevention piglet iron deficiency anemia is: the ability of the absorption ferrum of enhancing body, increase Abwehrkraft des Koepers, specificity and nonspecific immunity comprise the generation that increases antibody and complement, increase the generation of cytokine; Antibacterial, elimination complication; Protect the liver and protect kidney, thereby guarantee normal physiological function and the resistance against diseases of eliminating paathogenic factor.It is primary treatment principle that iron supplement spleen invigorating, QI invigorating and blood producing are take in the present invention, a kind of medicine that is used for the treatment of piglet iron deficiency anemia is provided, has comprised following raw medicinal material: Poria, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Scutellariae, Radix Polygoni Multiflori, Herba Artemisiae Scopariae, Rhizoma Atractylodis, the Radix Astragali, Radix Gentianae, Radix Glycyrrhizae, Fructus Quisqualis, Radix Polygalae, Radix Codonopsis, Radix Ophiopogonis, Fructus Amomi, Radix Platycodonis, the Radix Aucklandiae, Semen Ziziphi Spinosae and Rhizoma Zingiberis Recens.
Wherein, the pharmacological property of each raw medicinal material is:
Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
The Rhizoma Atractylodis Macrocephalae: can strengthen significantly shrinkage amplitude, the contraction frequency of intestinal smooth muscle, extend intestinal smooth muscle contraction time under anaerobic conditions, adjust gastrointestinal motility function, there is antiulcer, protect the liver the effect with enhancing human body immunity function.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.< < property of medicine opinion > > carries it: monarch, and sweet in the mouth, pungent, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.
Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Rhizoma Chuanxiong: pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.< < herbal classic > > carries it: main apoplexy enters brain headache, arthralgia due to cold, and clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity.< < does not record > > and carries it: " except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle; before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors; soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.
Radix Polygoni Multiflori: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.1. effect for reducing blood fat: give rabbit feed Radix Polygoni Multiflori and cholesterol simultaneously, the matched group that its formed tremulous pulse medicated porridge sample pathological changes is more singly fed cholesterol is light, serum ornitrol level is also lower, and in vitro tests Radix Polygoni Multiflori can be combined with cholesterol, at rabbit intestinal, can reduce cholesteric absorption; Have and think that the lecithin containing in Radix Polygoni Multiflori is relevant with treatment atherosclerosis.But have report with Radix Polygoni Multiflori feed Experimental Atherosclerotic Rabbits, though it is slower to make cholesterol increase, pathological changes is slightly light, is not showing, and its curative effect is unsure.No matter the Columba livia of Shouwuyishoudan to experimental atherosclerosis, be that medicine and cholesterol are applied simultaneously, or with administration after cholesterol formation hypercholesterolemia, all can show reduction serum ornitrol, but endarterium pathological changes is had no significant effect.Shouwuyishoudan has to formation and the lipidosis of the aortic tunica intima speckle of Experimental Atherosclerotic Rabbits the effect of alleviating, but also has report not make significant difference to Lipid and the variation of aorta pathology.There are research Shouwuyishoudan and wherein 4 impacts that single medicinal material Flos Lonicerae, the Cortex Eucommiae, Fructus Rosae Laevigatae, Fructus Mori cream absorb rat intestinal cholesterol, prove that front two medicines are like reducing the cholesteric absorption of intestine in rats, but full side does not show sure effect, may be because the content of the Cortex Eucommiae and Flos Lonicerae in full side be than the little cause of dosage of application separately.2. the effect to blood glucose: rise to after the oral decoct of rabbit in 30～60 minutes blood glucose amount and reach topnotch, then reduce gradually, after 6 hours, blood glucose amount is lower by 0.03% than normal.Antibacterial action: Radix Polygoni Multiflori has inhibitory action to mycobacterium hominis, the experiment of bacterium flexneri test tube.4. other effects: the chrysophanol proposing in Radix Polygoni Multiflori, can promote the motion of intestinal tube, and the neural duration of die-offing, impel neural excitation, increase muscle duration, make muscular paralysis.Radix Polygoni Multiflori has excitation to isolated frog heart, and to tired heart, cardiotonic is more remarkable especially.The fresh milk of Radix Polygoni Multiflori stem is applied in to the outside of belly of mouse ear, smears after medicine, the outside of belly and the back side of ear all sees and thickens, and its variation on histology is to similar by the result of phospholipid gained; Can be used to treat scrofula.
Herba Artemisiae Scopariae: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Rhizoma Atractylodis have drying damp and strengthening spleen, the effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia.< < pearl sac > > day: " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove." < < Compendium of Materia Medica > > says: " control damp-phlegm prolonged fluid-retention ... and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down." < < Newly Revised Canon of Materia Medica > > claims that it can " diuresis ".
The Radix Astragali: take tonify deficiency as main, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and immunologic function that can enhancing body, therefore can also be for preventing the generation of some infectious disease.< < book on Chinese herbal medicine meets former > > to carry: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly sends out, and has antiperspirant to stop." be the good medicine of promoting resistance and defence disease.
Radix Gentianae: hardship; Cold in nature.Return: liver; Gallbladder meridian.Function cures mainly: heat clearing and damp drying; Eliminating pathogen in the liver arresting convulsion.Main jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; Hypochondriac pain bitter taste; Calentura convulsion with spasms.1. on gastral, affect Radix Gentianae or gentiopicrin can promote gastric juice and gastric acid secretion, with gentiopicrin, cause the Canis familiaris L. of gastric fistula pipe oral, can promote gastric secretion, and can make free hydrochloric acid increase, appetite is promoted.Sublingual smear or intravenous injection invalid, therefore think that gentiopicrin can directly promote gastric secretion and free acid is increased.2. function of gallbladder promoting and hepatoprotective effect are got health and liver injury white mice, and duodenum gives 50g/kg Radix Gentianae injection or healthy dogs intravenous injection 4.5g/kg, all can show increase bile flow.From the bile secretion flow curve of dog, there are as seen two peaks when administration 5 minutes and 20 minutes.The mouse liver acute injury model that gentiopicrin causes carbon tetrachloride and D-Gal (Galn) has protective effect, can alleviate administration treated animal hepatic necrosis and liver cell lesion degree, the hepatocyte glyconeogenesis obstacle due to antagonism carbon tetrachloride.Radix Gentianae injection 25g/kg subcutaneous injection, to the experimental Jaundice Model of α-naphthalene isothiocyanic acid induced mice (hyperbilirubinemia and cholestasis), can reduce serum bilirubin level significantly.3. diuresis Radix Gentianae injection 10g/kg, ear vein injection, can make 5 rabbit by administration before every 30 minutes isuria amount 0.76ml be increased to 2.64ml (p<0.1), prompting Radix Gentianae has obvious diuresis.4. 14 kinds of agueweeds of antibacterial action examination, 7 pairs of root nodule bacterias wherein, escherichia coli, bacillus subtilis, Agrobacterium tumefaciens etc. have effect.Radix Gentianae water logging agent has inhibitory action in various degree to dermatophytess such as trichophyton gypseum star nocardias in vitro.Test tube method proves that Radix Gentianae decoct is to bacillus pyocyaneus, Bacillus proteus, and Bacillus typhi, dysentery bacterium, staphylococcus aureuses etc. have inhibitory action in various degree.5. couple central nervous system's effect erythricine is excitation to central nervous system of mice, but occurs anesthetic action during larger dose.Separately have report, erythricine 25-200mg/kg lumbar injection or gavage, have central inhibitory action, can reduce spontaneous activity in mice and orienting reflex, extend the length of one's sleep of pentobarbital sodium and chloral hydrate, reduce body temperature, relaxed muscle, and the toxicity of reduction strychnine etc.; 200-400mg/kg has sedation to mice, can reduce the mobility of mice.Swertiamarin can suppress central nervous system, has analgesia and sedation.Intestinal and uterine smooth muscle are had to spasmolysis; 6. other effects are when take in a large number, can overslaugh digestion, time have headache, Blushing, sinks into giddy.Once with the cancer eliminating pill containing Radix Gentianae (kind is unreceipted), tried out in the little cancer of mice Emhorn ascites, proved antineoplastic action.Tinctura gentianae heavy dose has hypotensive effect to anesthetized animal, and can suppress heart, makes decreased heart rate.The gentiopicrin proposing from G.lutea has higher toxicity for malaria heating and the effect such as antibiotics formaldehyde experimental arthritis is swollen with plasmodium.Erythricine has hypotensive effect to cat, and rat formaldehyde experimental arthritis is swollen and has antiinflammatory action.To chloropicrin induced mice, delayed allergy has inhibitory action to Radix Gentianae water extract.
Radix Glycyrrhizae: property is flat, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Fructus Quisqualis: sweet, temperature.Return spleen, stomach warp.Function cures mainly: killing insect and eliminating accumulation.For ascarid, enterobiasis, abdominal pain due to worm stagnation, infantile malnutrition.
Radix Polygalae: bitter, pungent, warm.GUIXIN, kidney, lung meridian.Function cures mainly: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, and detumescence.The insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Radix Codonopsis: there is invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition leukopenia chemotherapy radiotherapy being caused has castering action.< < Bencao Congxin > > records: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than middle feeble QI, in order to adjust, mend, very smooth and proper.”
Radix Ophiopogonis: sweet in the mouth, micro-hardship, be slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.< < Mingyi Bielu > > records: treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst, preventing or arresting vomiting is told, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protect god, determine lung qi, settling five organs, makes us fertile strong.The newly organized > > of < < book on Chinese herbal medicine records: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often use less and can not be successfully for unfortunately also.Do not know that Radix Ophiopogonis is necessary multiplex, strength begins large, and Gai Huofu, in lung, sparkles dry interior liquid, and more than Radix Ophiopogonis, fire can not be made; Heat is vehement in stomach, endures its moon to the greatest extent, and more than Radix Ophiopogonis, fire can not cease.The fire that more has bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to the heat of bladder also, with the medicine of water flowing, do not imitate, with the agent of pathogenic fire reducing, do not imitate, how does this use again? the gas of lid bladder, must the clear respectful order of the part of the body cavity above the diaphragm housing the heart and lungs go, and fire is to decline, and water is lower logical.The clear respectful order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, heat of the lung, and making that lung is respectful is clearly not all right, and bladder fire closes, water also closes.Therefore wish is led to bladder person, gas that must lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpfully, if do not have benefit in clear Radix Ophiopogonis eventually, can rush down the fire of bladder, and don't damage the gas of bladder, yet use less it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and begin have Ji also.
Fructus Amomi: acrid in the mouth, warm in nature, Fructus Amomi Main Function is in stomach, kidney and the spleen of human body, can circulation of qi promoting seasoning, stomach function regulating is amusing, removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive, < < book on Chinese herbal medicine converges in speech > > to be described: Fructus Amomi, the gentle medicine of warming middle-JIAO also.If the gas of part of the body cavity above the diaphragm housing the heart and lungs stalk is contrary, not, the gas of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is curbed and is not gone up, and middle Jiao's airsetting is poly-and not easypro, with Fructus Amomi, controls it, proves effective the most prompt.So ancient prescription multiplex with antiabortive what also? cover depressed pain, QI rising in reverse order is frequent fetal movement, the pungent perfume (or spice) of this medicine and altering, temperature and not strong, profit and not cutting, and and out of question, unobstructed three warmers, warm row six internal organs, warm lung is amusing, kidney is supported in nourishing the stomach, the Shu Da liver and gall gas of injustice that has some setbacks, so be apt to also antiabortive.Shen Ze executes and says: Fructus Amomi Wen Xinxiang is loose, and preventing or arresting vomiting leads to diaphragm, reaches gas also; Antiabortive relieving distension, reaches middle gas also; Antidiarrheal dysentery, determine renal mass, reach the therapeutic method to keep the adverse QI flowing downwards also.With the same use of the Radix Aucklandiae, control disorder of QI speed especially.
Radix Platycodonis: be the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.The direct stimulation of contained platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflexive ground increases bronchial mucosa hypersecretion, is easy to discharge; Radix Platycodonis has antitussive effect, has the antiinflammatory of enhancing and immunization, and its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer is had to preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, and relaxing smooth muscle.Platycodin has very strong haemolysis, but destroy and lose haemolysis oral can decomposition in digestive tract.
The Radix Aucklandiae: pungent acrid in the mouth; Bitter; Warm in nature.Cure mainly: born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.< < medicineization justice > >: the Radix Aucklandiae, fragrant can ventilation, and close the five internal organs, for adjusting all gas key medicines.With this, control the vexed belch of painful abdominal mass, edema abdominal distention, dysentery beriberi, all adjusts the merit of stagnant loose gas.But the pungent fragrant sun that belongs to, sun rises floating, as stagnant in middle Jiao, lower close-burning, row under must assistant Semen Arecae falling; Dry because of property perfume (or spice), same Rhizoma Coptidis, Radix Scutellariae are controlled dysentery, and same Cortex Phellodendri, Radix Stephaniae Tetrandrae are controlled beriberi, and all the cold medicine of mat and make it is dry, uses this god.If anger is gone against, attack punching, all overly have a pain, with this, lung qi is adjusted, lung qi, from volt, if hepatic depression causes pain between side of body rib lower abdomen, is dredged it with Pericarpium Citri Reticulatae Viride, makes irritability row, and blood along pain only.The newly organized > > of < < book on Chinese herbal medicine: Radix Aucklandiae (Radix Vladimiriae), only can use less for assistant makes, make that gas is capable stops, and be not its can QI invigorating and reuse also.Approximately, with Radix Aucklandiae (Radix Vladimiriae), by one minute, two minutes, to a money, stop, break and do not float on outside a money, too much instead without effect, the benefit of assistant and not mending, rushing down of assistant and also not rushing down also.
Semen Ziziphi Spinosae: sweet, sour, flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, and mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Rhizoma Zingiberis Recens: warm in nature, its distinctive " gingerol " can stimulating gastrointestinal mucosa, make gastrointestinal tract congested, digestion power strengthens, and can effectively treat the abdominal distention of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after Rhizoma Zingiberis Recens, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the pathogenic bacteria in body, cold is together taken out of simultaneously.When health, eaten cold and cool thing, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because of the cold various discomforts that remake of human body.For the pungent stomachic of armaticity, there are the effects such as warm, excited, diaphoresis, preventing or arresting vomiting, removing toxic substances, warming the lung to relieve cough, for fish Eriocheir sinensis poison, the drug intoxication such as the Rhizoma Pinelliae, Rhizoma Arisaematis have Detoxication especially.Be applicable to affection of exogenous wind-cold, headache, phlegm retention, cough, gastrofrigid vomiting; After suffering ice and snow, wet, the cold invasion and attack of water, suddenly with ginger decoction, drink it, can promote blood, disperse cold-evil.
Medicine of the present invention also comprises: Semen Nelumbinis, Rhizomadioscoreae, Radix Dipsaci, Pericarpium Citri Reticulatae and Fructus Crataegi.
Semen Nelumbinis: sweet, puckery, flat.Return spleen, kidney, heart channel.Function cures mainly: spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia.
Rhizomadioscoreae: sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Function with cure mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.The < < book on Chinese herbal medicine > > that looks for the truth: " enter in drugs for nourishing yin and should give birth to use, entering spleen reinforcing lung medicine should use by parching to brown." " this genus food, though gas is warm and flat, is the moon of spleen reinforcing lung.Can moisten fur, longue meat, sweet in the mouth is held concurrently salty, again can kidney tonifying reinforcing YIN-essence." invigorating the spleen and replenishing QI: Rhizoma Dioscoreae is planted trace element because being rich in 18 seed amino acids and more than 10; and other mineral; so have strengthening the spleen and stomach, tonifying the lung kidney, invigorating the spleen and replenishing QI, spleen invigorating tonify deficiency; the effects such as beneficial essence, beneficial heart and tranquilizing mind of reinforcing the kidney; there be saying of " all kinds of diseases and ailments are reinforced the kidney, controlled to spleen invigorating tonification, taste essence, treats five kinds of strain and seven kinds of impairment " in Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > >.Quench one's thirst and promote the production of body fluid: this Rhizoma Dioscoreae has the effect of the life of quenching one's thirst: Chinese traditional treatment asthenia is quenched one's thirst in (diabetes) prescription often has Rhizoma Dioscoreae single to use, or share with other medicines, and effect is better.Health care: because fresh Rhizoma dioscoreae is rich in multivitamin, aminoacid and mineral, can prevent and treat Human Lipid Metabolism abnormal, and arteriosclerosis, to safeguarding that insulin normal function also has certain effect, there is enhancing body immunity, beneficial heart and tranquilizing mind, rather cough the health-care effects such as Dingchuan, slow down aging.Skin care: Yuan Dynasty taste expert Li Gao says: " control xerosis cutis and moisten it with this thing." Li Shizhen (1518-1593 A.D.) writes: " Rhizoma Dioscoreae can be moistened fur." Rhizoma Dioscoreae is to nourishes rough skin, vigorous and graceful skin care has unique curative effect.Rhizoma Dioscoreae special pharmacological function: the copper ion in Rhizoma Dioscoreae and connective tissue have very big help to human development, vascular system disease is had to obvious curative effects, calcium in Rhizoma Dioscoreae, muscle and tendon injury is damaged to bone, osteoporosis, loss of tooth has high curative effect, chilblain, diabetes, hepatitis, children's's diarrhea, enuresis, baby's dyspepsia, ulcerative stomatitis, pulmonary tuberculosis, the inferior patient of woman in menstrual period band are also had to good curative effect, and using for a long time can be clear-headed and clear-sighted, life lengthening.Control feed desire: in Rhizoma Dioscoreae, be rich in a large amount of protein, vitamin B group, vitamin C, vitamin E, glucose, crude protein aminoacid, bile alkaline, allantoin etc.; Wherein important nutritional labeling Rhizoma Dioscoreae soap is the precursor materials of synthetic estrogen, nourishing YIN and invigorating YANG, strengthens metabolic effect; And phlegmatic temperament of the GL-PP composition containing in fresh tuber, zymigen etc. can be prevented cadiovascular lipidosis, contribute to digestion and the absorption of gastrointestinal.
Radix Dipsaci: bitter in the mouth, pungent, slightly warm in nature; Return liver, kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Only metrorrhagia.< < herbal classic > > records: the main typhoid fever of Radix Dipsaci, and tonifying for the deficiency, incised wound, carbuncle and ulcer, folding falls, reuniting the fractured tendons and bones, married woman's breast is difficult, takes for a long time physical strength profiting.< < does not record > > and records: main metrorrhagia is leaked blood, incised wound blood internal hemorrhage due to trauma, pain relieving, granulation promoting Rou ， Wan wound, stagnant blood, lumbago, joint emergency.< < property of medicine opinion > > records: main wound absolutely, remove all temperature poison, and can declare qualcomm meridian.< < Japan hanako materia medica > > records: help gas, blood circulation regulating, mends five kinds of strain and seven kinds of impairment, broken crux blood stasis, detumescence poison, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, acute mastitis, scrofula, flutter damage, all diseases after married woman is antenatal, yellowish complexion edema due to deficiency, urine reducing, stopping leak essence, hematuria, vaginal bleeding during pregnancy, uterus is cold.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > > records: tonifying liver, and bone and muscle strengthening, determines meridians, and only in warp, (muscles and bones) ached, antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, the stillborn fetus that falls, the cough-relieving hemoptysis of coughing, controls red white turbid urine.This sketch of < < the southern regions of the Yunnan Province says that > > records: control all innominate toxic swellings, Fructus Myricae rubrae, day all skin ulcers of bubble.< < book on Chinese herbal medicine converges says that > > records: Radix Dipsaci, mend the medicine of continuous blood vessels also.On the whole the blood vessels that broken are non-, and this is continuous, and non-this of muscles and bones of being hindered is not supported, and non-this unfavorable, to be damaged pregnant non-this uneasiness of tire in joint that institute is stagnant, takes informal dress for a long time, can physical strength profiting, there is the effect of mending the blood of being injurious to life, and tonify without causing stagnation, row and not letting out, how also Gu Nvke, surgery take perseverance.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at again drying dampness to eliminate phlegm, for controlling damp-phlegm, stop up the conventional key medicine of lung, abundant expectoration cough, for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea, the fit applications such as normal and Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Can spleen invigorating because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, Pericarpium Citri tangerinae again can with in, can control stomach-QI being unable to descend normally, nausea and vomiting.
Fructus Crataegi: section is dried, putting uses force in pot fries to outer wrinkly face brown, inner yellowish-brown as degree greatly, spray clear water, and taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, the effect of promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, Fructus Crataegi has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increase myocardial contraction, to arrhythmia.Therefore, be conducive to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine that is used for the treatment of iron deficiency anemia, medicine is comprised of following raw medicinal material: Poria 31 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Angelicae Sinensis 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Scutellariae 17 weight portions, Radix Polygoni Multiflori 21 weight portions, Herba Artemisiae Scopariae 18 weight portions, Rhizoma Atractylodis 16 weight portions, the Radix Astragali 20 weight portions, Radix Gentianae 23 weight portions, Radix Glycyrrhizae 16 weight portions, Fructus Quisqualis 21 weight portions, Radix Polygalae 18 weight portions, Radix Codonopsis 14 weight portions, Radix Ophiopogonis 18-21 weight portion, Fructus Amomi 15 weight portions, Radix Platycodonis 20 weight portions, the Radix Aucklandiae 22 weight portions, Semen Ziziphi Spinosae 21 weight portions and Rhizoma Zingiberis Recens 15 weight portions.
The preparation method of said medicine comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 40%, collects by the raw material fine powder of 120 mesh sieves, and particulate matter remaining after sieving is standby;
B, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 7 times of amounts is 85%, each 2 hours, extracted twice liquid is merged standing, obtain extracting solution 1, medicinal residues are standby;
C, the medicinal residues that in step b, ethanol extraction is crossed are added to 5 times of water gaging heating and refluxing extraction 2 times, each 2 hours, 2 extracting solution are merged standing, obtain extracting solution 2;
D, extracting solution 1 and extracting solution 2 merged, filter 1.38 filtrate when concentrating under reduced pressure relative density is 60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicated powder.
Embodiment 2 medicines 2
The embodiment of the present invention provides a kind of medicine that is used for the treatment of piglet iron deficiency anemia, raw material by following parts by weight forms: Poria 21 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Angelicae Sinensis 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Scutellariae 17 weight portions, Radix Polygoni Multiflori 21 weight portions, Herba Artemisiae Scopariae 18 weight portions, Rhizoma Atractylodis 17 weight portions, the Radix Astragali 20 weight portions, Radix Gentianae 23 weight portions, Radix Glycyrrhizae 17 weight portions, Fructus Quisqualis 20 weight portions, Radix Polygalae 18 weight portions, Radix Codonopsis 14 weight portions, Radix Ophiopogonis 21 weight portion, Fructus Amomi 15 weight portions, Radix Platycodonis 20 weight portions, the Radix Aucklandiae 22 weight portions, Semen Ziziphi Spinosae 21 weight portions, Rhizoma Zingiberis Recens 15 weight portions, Semen Nelumbinis 17 weight portions, Rhizomadioscoreae 13 weight portions, Radix Dipsaci 13 weight portions, Pericarpium Citri Reticulatae 15 weight portions and Fructus Crataegi 15 weight portions.
In order better to realize above-mentioned purpose, the invention provides the preparation method of the medicine that is used for the treatment of piglet iron deficiency anemia, described preparation method comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves, and particulate matter remaining after sieving is standby;
B, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 6 times of amounts is 85%, each 2 hours, extracted twice liquid is merged standing, obtain extracting solution 1, medicinal residues are standby;
C, the medicinal residues that in step b, ethanol extraction is crossed are added to 6 times of water gaging heating and refluxing extraction 2 times, each 2 hours, 2 extracting solution are merged standing, obtain extracting solution 2;
D, extracting solution 1 and extracting solution 2 merged, filter 1.38 filtrate when concentrating under reduced pressure relative density is 50 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicated powder.
Toxicity test
Select SD rat, the molten water of medicine giving in the embodiment of the present invention 1 of variable concentrations (18.0,6.0,2.0g crude drug/kg) gavages, every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: medicine of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test medicine of the present invention, in the administration in continuous 90 days of high, medium and low three dosage, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dosage safety of the clinical drug application of prompting embodiments of the invention 1 is higher.The medicine 2 of the embodiment of the present invention 2 of take is experimental subject, takes above-mentioned same counteracting toxic substances mode, and result and embodiment 1 come to the same thing, and the dosage safety of clinical practice is higher.
Clinical trial
(1) laboratory animal
300 bull piglets of different pigsties are found on pig farm, Weifang City, Shandong in JIUYUE, 2012, occur that spirit is depressed, peel off lie prostrate, loss of appetite, ear vein do not appear, visual mucosal pallor, slight xanthochromia, contrary vertical by hair, accelerated breathing, palpitate quickly, body temperature is not high, occurs indivedual piglet phenomena of mortality, through cuing open inspection, find that dead piglet muscle color is thin out, heart diffusion, liver enlargement and have steatosis, blood is thinner, occurs liquid, pulmonary edema in pleural space.Blood examination hemoglobin content is 30-40mg/ml.Be diagnosed as piglet iron deficiency anemia disease, choose 300 ill piglets as experiment pig.
(2) test method
300 ill piglets are divided into three experimental grouies at random, and 100 every group, three experimental grouies are used respectively the medicine (embodiment group 1) of the embodiment of the present invention 1, medicine (embodiment group 2) and the conventional medicament (matched group) of embodiment 2 are treated.Embodiment group 1 and embodiment group 2 are sneaked into medicine 1 and medicine 2 in water and are gavaged according to the part by weight of 1:5 respectively, every day twice, use continuously 5-10 days; Above-mentioned conventional medicament is iron dextran inj, and the precious pharmaceutcal corporation, Ltd in the Holy Land, Shandong produces, lot number 20120512, and inject 1-2 every day, treats continuously 12 days.
(3) criterion of therapeutical effect
Effective: spirit, appetite, breathing etc. all recover normally, by hair, without disorderly thick, skin and visual mucosa are without pale phenomenon;
Effective: spirit, appetite, breathing etc. are basic recovers normal, skin and visual mucosa be without pale phenomenon, and two ear vein blood vessels can see but be not obvious, and acupuncture amount of bleeding is less;
Invalid: symptom does not disappear or sb.'s illness took a turn for the worse even death sentence.
Wherein, effective and effective quantity percentage ratio sum is effective percentage.
(4) therapeutic effect
Result is as shown in table 1, and from therapeutic effect, adopting medicine of the present invention is more than 94% to the treated effect of piglet iron deficiency anemia disease, higher than matched group.
Table 1 therapeutic effect synopsis
Figure 2013107189113100002DEST_PATH_IMAGE001
Data from table 1: compare with matched group, use the Drug therapy piglet iron deficiency anemia disease of the embodiment of the present invention 1 and embodiment 2, have advantages of evident in efficacy, cure rate is high; In long-term observation subsequently, find, the effective ill pig of embodiment group 1 and embodiment group 2 treatments again sickness rate is starkly lower than the pig of matched group.
Concrete case
Case 1
Pig grandson raiser in August, 2012 find 13 20 age in days piglets all spirit in various degree depressed, peel off lie prostrate, loss of appetite, ear vein do not appear, visual mucosal pallor, slight xanthochromia, contrary vertical by hair, accelerated breathing, accelerated symptom, sampling blood examination hemoglobin content average out to 37mg/ml, be diagnosed as piglet iron deficiency anemia, use medicine 1 treatment of the embodiment of the present invention 1, medicine 1 is sneaked in water and gavaged according to the part by weight of 1:5, twice of every day, use 8 days continuously, it is normal that piglet all recovers.
Case 2
Pig Liu raiser during the 6-7 month in 2012, find 27 piglets all spirit in various degree depressed, peel off lie prostrate, loss of appetite, ear vein do not appear, visual mucosal pallor, slight xanthochromia, contrary vertical by hair, accelerated breathing, accelerated symptom, also there is a dead piglet, through cuing open inspection, find that dead piglet muscle color is thin out, heart diffusion, liver enlargement and have steatosis, blood is thinner, in pleural space, there is liquid, pulmonary edema.Be diagnosed as piglet iron deficiency anemia, use medicine 2 treatments of the embodiment of the present invention 2, medicine 2 is sneaked in water and gavaged according to the part by weight of 1:5, every day twice, use continuously 5 days, 26 piglets all recover normal.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (8)

1. the medicine that is used for the treatment of piglet iron deficiency anemia, it is characterized in that, described medicine comprises following raw medicinal material: Poria, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Scutellariae, Radix Polygoni Multiflori, Herba Artemisiae Scopariae, Rhizoma Atractylodis, the Radix Astragali, Radix Gentianae, Radix Glycyrrhizae, Fructus Quisqualis, Radix Polygalae, Radix Codonopsis, Radix Ophiopogonis, Fructus Amomi, Radix Platycodonis, the Radix Aucklandiae, Semen Ziziphi Spinosae and Rhizoma Zingiberis Recens.
2. the medicine that is used for the treatment of piglet iron deficiency anemia according to claim 1, it is characterized in that, described medicine is comprised of following raw medicinal material: Poria 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 15-25 weight portion, Radix Angelicae Sinensis 15-25 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Radix Scutellariae 10-30 weight portion, Radix Polygoni Multiflori 15-25 weight portion, Herba Artemisiae Scopariae 13-20 weight portion, Rhizoma Atractylodis 15-20 weight portion, Radix Astragali 10-30 weight portion, Radix Gentianae 15-30 weight portion, Radix Glycyrrhizae 15-20 weight portion, Fructus Quisqualis 12-28 weight portion, Radix Polygalae 15-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Ophiopogonis 15-30 weight portion, Fructus Amomi 10-20 weight portion, Radix Platycodonis 14-26 weight portion, Radix Aucklandiae 15-25 weight portion, Semen Ziziphi Spinosae 15-25 weight portion and Rhizoma Zingiberis Recens 10-20 weight portion.
3. the medicine that is used for the treatment of piglet iron deficiency anemia according to claim 1 and 2, it is characterized in that, described medicine is comprised of following raw medicinal material: Poria 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 18-23 weight portion, Radix Angelicae Sinensis 18-20 weight portion, Rhizoma Chuanxiong 14-17 weight portion, Radix Scutellariae 15-20 weight portion, Radix Polygoni Multiflori 18-23 weight portion, Herba Artemisiae Scopariae 16-20 weight portion, Rhizoma Atractylodis 15-18 weight portion, Radix Astragali 15-25 weight portion, Radix Gentianae 20-25 weight portion, Radix Glycyrrhizae 15-18 weight portion, Fructus Quisqualis 18-23 weight portion, Radix Polygalae 17-20 weight portion, Radix Codonopsis 13-15 weight portion, Radix Ophiopogonis 18-24 weight portion, Fructus Amomi 13-16 weight portion, Radix Platycodonis 18-22 weight portion, Radix Aucklandiae 20-24 weight portion, Semen Ziziphi Spinosae 19-23 weight portion and Rhizoma Zingiberis Recens 13-17 weight portion.
4. according to the medicine that is used for the treatment of piglet iron deficiency anemia described in claim 1-3 any one, it is characterized in that, described medicine also comprises: Semen Nelumbinis, Rhizomadioscoreae, Radix Dipsaci, Pericarpium Citri Reticulatae and Fructus Crataegi.
5. according to the medicine that is used for the treatment of piglet iron deficiency anemia described in claim 1-4 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Poria 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 15-25 weight portion, Radix Angelicae Sinensis 15-25 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Radix Scutellariae 10-30 weight portion, Radix Polygoni Multiflori 15-25 weight portion, Herba Artemisiae Scopariae 13-20 weight portion, Rhizoma Atractylodis 15-20 weight portion, Radix Astragali 10-30 weight portion, Radix Gentianae 15-30 weight portion, Radix Glycyrrhizae 15-20 weight portion, Fructus Quisqualis 12-28 weight portion, Radix Polygalae 15-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Ophiopogonis 15-30 weight portion, Fructus Amomi 10-20 weight portion, Radix Platycodonis 14-26 weight portion, Radix Aucklandiae 15-25 weight portion, Semen Ziziphi Spinosae 15-25 weight portion, Rhizoma Zingiberis Recens 10-20 weight portion, Semen Nelumbinis 10-20 weight portion, Rhizomadioscoreae 10-20 weight portion, Radix Dipsaci 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
6. according to the medicine that is used for the treatment of piglet iron deficiency anemia described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Poria 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 18-23 weight portion, Radix Angelicae Sinensis 18-20 weight portion, Rhizoma Chuanxiong 14-17 weight portion, Radix Scutellariae 15-20 weight portion, Radix Polygoni Multiflori 18-23 weight portion, Herba Artemisiae Scopariae 16-20 weight portion, Rhizoma Atractylodis 15-18 weight portion, Radix Astragali 15-25 weight portion, Radix Gentianae 20-25 weight portion, Radix Glycyrrhizae 15-18 weight portion, Fructus Quisqualis 18-23 weight portion, Radix Polygalae 17-20 weight portion, Radix Codonopsis 13-15 weight portion, Radix Ophiopogonis 18-24 weight portion, Fructus Amomi 13-16 weight portion, Radix Platycodonis 18-22 weight portion, Radix Aucklandiae 20-24 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Rhizoma Zingiberis Recens 13-17 weight portion, Semen Nelumbinis 15-20 weight portion, Rhizomadioscoreae 10-16 weight portion, Radix Dipsaci 10-15 weight portion, Pericarpium Citri Reticulatae 13-17 weight portion and Fructus Crataegi 13-18 weight portion.
7. according to the medicine that is used for the treatment of piglet iron deficiency anemia described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Poria 21 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions, Radix Angelicae Sinensis 19 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Scutellariae 17 weight portions, Radix Polygoni Multiflori 21 weight portions, Herba Artemisiae Scopariae 18 weight portions, Rhizoma Atractylodis 17 weight portions, the Radix Astragali 20 weight portions, Radix Gentianae 23 weight portions, Radix Glycyrrhizae 17 weight portions, Fructus Quisqualis 20 weight portions, Radix Polygalae 18 weight portions, Radix Codonopsis 14 weight portions, Radix Ophiopogonis 21 weight portion, Fructus Amomi 15 weight portions, Radix Platycodonis 20 weight portions, the Radix Aucklandiae 22 weight portions, Semen Ziziphi Spinosae 21 weight portions, Rhizoma Zingiberis Recens 15 weight portions, Semen Nelumbinis 17 weight portions, Rhizomadioscoreae 13 weight portions, Radix Dipsaci 13 weight portions, Pericarpium Citri Reticulatae 15 weight portions and Fructus Crataegi 15 weight portions.
8. a preparation method for the medicine that is used for the treatment of piglet iron deficiency anemia as described in claim 1-7 any one, is characterized in that, described preparation method comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects by the raw material fine powder of 120 mesh sieves, and particulate matter remaining after sieving is standby;
B, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 5～7 times of amounts is 85%, each 1～2 hour, extracted twice liquid is merged standing, obtain extracting solution 1, medicinal residues are standby;
C, the medicinal residues that in step b, ethanol extraction is crossed are added to 5～7 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing, obtain extracting solution 2;
D, extracting solution 1 and extracting solution 2 merged, filter 1.38 filtrate when concentrating under reduced pressure relative density is 50 ℃～60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicated powder.
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103892131A (en) * 2014-04-14 2014-07-02 中国科学院东北地理与农业生态研究所 Vegetable feed additive for enhancing immunity of piglets
CN104381687A (en) * 2014-11-24 2015-03-04 柳州华晟科技有限公司 Pig feed additive
CN104398789A (en) * 2014-12-09 2015-03-11 袁国防 Traditional Chinese medicine decoction for treating iron-deficiency anemia
CN104474440A (en) * 2014-11-27 2015-04-01 山东新希望六和集团有限公司 Pharmaceutical composition for treatment of nutritional anemia of piglets and preparation method thereof
CN104758781A (en) * 2015-03-18 2015-07-08 兰晓光 Traditional Chinese medicine composition for treating iron-deficiency anemia in the type of deficiency of spleen qi
CN105055744A (en) * 2015-07-29 2015-11-18 尹华江 Traditional Chinese medicine for treating stomach heat and dyspepsia in domestic animals and preparation method of traditional Chinese medicine
CN106421607A (en) * 2016-11-07 2017-02-22 四会市恒星智能科技有限公司 Traditional Chinese veterinary medicine capable of improving piglet immunity and preparation method thereof
CN116392544A (en) * 2023-03-20 2023-07-07 湖北希普生物科技有限公司 Traditional Chinese medicine composition for pigs and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102198151A (en) * 2011-05-18 2011-09-28 天津中敖生物科技有限公司 Bulk pharmaceutical of swine astragalus polyferose and preparation method thereof
CN103142751A (en) * 2012-04-19 2013-06-12 烟台海研制药有限公司 Traditional Chinese medicine composition for treating piglet iron-deficiency anemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102198151A (en) * 2011-05-18 2011-09-28 天津中敖生物科技有限公司 Bulk pharmaceutical of swine astragalus polyferose and preparation method thereof
CN103142751A (en) * 2012-04-19 2013-06-12 烟台海研制药有限公司 Traditional Chinese medicine composition for treating piglet iron-deficiency anemia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨正民: "应用中药治疗仔猪缺铁性贫血", 《养殖技术顾问》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103892131A (en) * 2014-04-14 2014-07-02 中国科学院东北地理与农业生态研究所 Vegetable feed additive for enhancing immunity of piglets
CN103892131B (en) * 2014-04-14 2015-10-28 中国科学院东北地理与农业生态研究所 A kind of plant feed addictive strengthening pigling immunity
CN104381687A (en) * 2014-11-24 2015-03-04 柳州华晟科技有限公司 Pig feed additive
CN104474440A (en) * 2014-11-27 2015-04-01 山东新希望六和集团有限公司 Pharmaceutical composition for treatment of nutritional anemia of piglets and preparation method thereof
CN104398789A (en) * 2014-12-09 2015-03-11 袁国防 Traditional Chinese medicine decoction for treating iron-deficiency anemia
CN104758781A (en) * 2015-03-18 2015-07-08 兰晓光 Traditional Chinese medicine composition for treating iron-deficiency anemia in the type of deficiency of spleen qi
CN105055744A (en) * 2015-07-29 2015-11-18 尹华江 Traditional Chinese medicine for treating stomach heat and dyspepsia in domestic animals and preparation method of traditional Chinese medicine
CN106421607A (en) * 2016-11-07 2017-02-22 四会市恒星智能科技有限公司 Traditional Chinese veterinary medicine capable of improving piglet immunity and preparation method thereof
CN116392544A (en) * 2023-03-20 2023-07-07 湖北希普生物科技有限公司 Traditional Chinese medicine composition for pigs and preparation method and application thereof

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