CN104068284B - For mixed feed treating gosling plague and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of for mixed feed treating gosling plague and preparation method thereof, wherein feedstuff includes following raw material: Semen Maydis, Semen Tritici aestivi, Semen setariae, Oryza glutinosa, DDGS, Testa Tritici, rapeseed cake, Semen phaseoli radiati powder, Amylum Nelumbinis Rhizomatis, Radix Dauci Sativae, Rhizoma Dioscoreae powder, Bombyx Batryticatus powder, Semen Maydis oil, Sal, vitamin premix and microelement pre-mix material；Its preparation method comprises the following steps: destruction step, batching step, granulation step.The invention has the beneficial effects as follows: the feedstuff of the present invention contains the Chinese medicine additive of the effect with invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal, can strengthening vital QI to eliminate pathogenic factors, there is the course for the treatment of shorter, curative effect is preferable, drug residue free, the advantages such as cost price is cheap, Chinese medicine additive cooperates with other feedstuffs, interact, gosling plague can not only be treated, can also meet the nutritional need of young goose, be particularly well-suited to the nutritional need suffering from gosling plague young bird goose, body also can be played certain health-care effect after eating this type of Carnis Anseris domestica by consumer.

Description

For mixed feed treating gosling plague and preparation method thereof

Technical field

The present invention relates to bird feed, particularly to a kind of for mixed feed treating gosling plague and preparation method thereof.

Background technology

Gosling plague is the acute or subacute septic infectious disease of the one by the young goose caused by Goose Parvovirus.Clinical Tired with spirit, peel off the most even, serosity nose liquid is flowed out in nostril, suffers from goose and again and again shakes the head, draws lark or yellow green loose stool, neural Disorder, the mucosa necrosis of small intestinal posterior segment comes off and fibrinous exudate solidification forms embolus, and shape such as sausage shape is characterized.Chang Cheng Deteriorated blood process, M & M is the highest, produces very harmful to foster goose industry.

Incidence: primary disease all has generation a whole year, but multiple it is born at the beginning of last month of spring in winter, the main young goose encroaching on 3-20 age in days. Gaggle falls ill in outbreak of epidemic, and morbidity suddenly, is propagated rapidly, has infectiousness and the mortality rate of height.Feeding and management level is low, Brooding temperature is low, and E She ground is moist, and hygienic conditions are poor, and goose age in days is little, and its sickness rate is higher.Protein content mistake in feedstuff Low, lack multivitamin and trace element, the existence of intercurrent disease etc. all can induce and aggravate generation and the death of primary disease.Ill Gaggle, if having mixed infection or secondary infection, its M & M is apparently higher than the Simple infection of primary disease.In recent years, Being found to have the ill gaggle morbidity age in days of indivedual goose field continuing to 33 day age at the latest, but mortality rate is extremely low.More than 40 ages in days Goose only, has no generation primary disease.

Clinical symptom: primary disease incubation period is 3-5 days, upsets as main performance with digestive system and central nervous system, Sick goose generally occurs that dysentery, mouth tell the symptom such as mucus, feed intake minimizing, and the situation of neck, tic occur turning in indivedual geese.Age in days is bigger Typically no there is nervous symptoms, and morbidity goose shows as dysentery, feed intake reduces.

Length according to the course of disease is different, can be faced and examine type and be divided into acute, acute and three kinds of subacute type.? , there is septicemia and sudden death in the multiple young goose being born in 3-10 age in days of acute, it is common that lose and have any prodrome, or After there is dull mind, a few hours i.e. present weak, fall down to the ground and draw lower limb, struggle several lower the most dead, and patient's condition is propagated rapidly, in a few days Can propagate can group.The multiple young goose being born in about 15 ages in days of acute, ill young goose performance spirit is depressed, loss of appetite or useless Absolutely, disorderly, head and neck shrinks feather pine, closes one's eyes slow-witted vertical, peels off and stay alone, be reluctant to walk about, slow in action；Search for food though can do as everybody else does, but adopted The grass obtained is not swallowed, with adopting with losing；Serosity nose liquid is flowed out in sick young goose nostril, stains nares, and sick goose shakes the head again and again；Enter And amount of drinking water increases, engender and have loose bowels that ash discharge white or the water sample loose stool of lark be often Rice & peanut milk sample muddiness and with bubble Or having fibrous fragment, perianal tomentum stains；Beak end and web subduing (cyanosis)；Indivedual ill young goose is had the most before to go out The nervous symptoms such as existing cervical region torsion or tic, paralysis.According to clinical findings, most of young geese betide acute, and the course of disease is generally 2-3 days, increasing with ill young goose age in days, the course of disease gradually transfers subacute type to.The subacute type of type typically occurs in popular latter stage Or the young goose that 20 is more than age in days, its symptom is slight, mainly to be slow in action, walks about and waves, has loose bowels, and feed intake reduces, spirit shape State is the poorest to be characterized.General 4-7 days of the course of disease, or have longer, have the only a few disease goose can be with spontaneous recovery, but young goose material feeding is abnormal, Growth promoter is seriously hampered, becomes " stiff goose ".

Pathological change: acute case, cuts open rarely seen Duodenal Mucosa swelling during inspection congested, sometimes visible hemorrhage, Substantial amounts of faint yellow mucus it is coated with above it；Liver enlargement hyperemia is hemorrhage, and matter is crisp frangible；Gallbladder swells, is full of bile, other The pathological changes of internal organs is inconspicuous.

Acute case, liver enlargement seen from when dissected, congested hemorrhage, matter is crisp；Gallbladder swells, and is full of dirty-green bile； Spleen enlargement, in kermesinus；Kidney slightly enlargement, in kermesinus, matter is crisp frangible.Intestinal has obvious characteristic pathological to change； The case that the course of disease is slightly grown, the stage casing of small intestinal and back segment, especially at the intestinal segment of yolk suspensor Yu ileocecus, outward appearance is expanded, intestinal Mucosa hyperemia is hemorrhage, and inflammation necrosis comes off, with the embolus that fibrinous exudate solidification forms (2-5 centimetre) different in size, body Long-pending increase, shape such as sausage shape, it is solid that hands touches quality at sausage shape, and after cutting off intestinal, visible intestinal wall is thinning, is full of greyish white in enteric cavity Color or flaxen embolus shape thing (being commonly called as the change into sausage excrement above, be a characteristic pathological change of gosling plague).Also There is part disease goose small intestinal posterior segment to have no substantially to expand, but visible intestinal mucosa hyperemia is hemorrhage, has substantial amounts of cellulose in enteric cavity Property grumeleuse and fragment, do not form solid embolus.

At present, treatment gosling plague mainly injection goose plague vaccine and antibiotic, such as gosling plague's serum, penicillin, streptomycin Deng.Therapeutic scheme, medicine are the most limited, do not reach preferable therapeutic effect, and treatment cost is higher.But Chinese medicine is little The goose plague initial stage not only has the effects such as the antiviral of western modern medicine, also has invigorating the spleen and benefiting QI, the effect of removing toxic substances antidiarrheal, can righting dispel Heresy, improves the immunity of organisms of ill goose, selected natural Chinese medicines material, makes drug effect directly arrive focus, and the course for the treatment of is shorter, and curative effect is relatively Good, prolonged application has no drug resistance, drug residue free, and cost price is cheap, is possible not only to effective symptom management, and consumer eats Also body can be played the advantages such as certain health-care effect after this type of Carnis Anseris domestica.

Summary of the invention

The technical problem to be solved is to be to provide raising of a kind of Chinese medicine additive for treating gosling plague Material, uses the Feed Energy containing this Chinese medicine additive to overcome the various defects of Chinese medicine of the prior art and Western medicine, has strong Spleen QI invigorating, the effect of removing toxic substances antidiarrheal, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill goose, the course for the treatment of is shorter, and curative effect is preferable, long Phase application has no drug resistance, drug residue free, and cost price is cheap, is possible not only to effective symptom management, and consumer eats this type of Also body can be played the advantages such as certain health-care effect after Carnis Anseris domestica.

In order to realize foregoing invention purpose, the invention provides a kind of feedstuff for treating gosling plague, be used for treating little The mixed feed of goose plague, it is characterised in that described feedstuff includes following raw material: Semen Maydis, Semen Tritici aestivi, Semen setariae, Oryza glutinosa, DDGS, Testa Tritici, Rapeseed cake, Semen phaseoli radiati powder, Amylum Nelumbinis Rhizomatis, Radix Dauci Sativae, Rhizoma Dioscoreae powder, Bombyx Batryticatus powder, Semen Maydis oil, Sal, vitamin premix and trace element premix Material.

In described feedstuff, the parts by weight of each raw material are: Semen Maydis 30-60 weight portion, Semen Tritici aestivi 20-40 weight portion, Semen setariae 15- 20 weight portions, Oryza glutinosa 15-30 weight portion, DDGS 10-15 weight portion, Testa Tritici 20-30 weight portion, rapeseed cake 15-25 weight portion, green Semen Glycines powder 10-15 weight portion, Amylum Nelumbinis Rhizomatis 10-30 weight portion, Radix Dauci Sativae 10-20 weight portion, Rhizoma Dioscoreae powder 10-20 weight portion, Bombyx Batryticatus powder 10- 30 weight portions, Semen Maydis oil 3-7 weight portion, Sal 2-5 weight portion, vitamin premix 0.1-0.5 weight portion and trace element are pre- Batch mixing 0.1-0.5 weight portion.

Described feedstuff also includes Chinese medicine additive, and in described feedstuff, the parts by weight of each raw material are: Semen Maydis 30-60 weight Part, Semen Tritici aestivi 20-40 weight portion, Semen setariae 15-20 weight portion, Oryza glutinosa 15-30 weight portion, DDGS 10-15 weight portion, Testa Tritici 20-30 Weight portion, rapeseed cake 15-25 weight portion, Semen phaseoli radiati powder 10-15 weight portion, Amylum Nelumbinis Rhizomatis 10-30 weight portion, Radix Dauci Sativae 10-20 weight portion, mountain Medicated powder 10-20 weight portion, Bombyx Batryticatus powder 10-30 weight portion, Semen Maydis oil 3-7 weight portion, Sal 2-5 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-5 weight portion.

In described feedstuff, the parts by weight of each raw material are preferably: Semen Maydis 46 weight portion, Semen Tritici aestivi 31 weight portion, Semen setariae 18 weight Amount part, Oryza glutinosa 23 weight portion, DDGS 12 weight portion, Testa Tritici 25 weight portion, rapeseed cake 21 weight portion, Semen phaseoli radiati powder 12 weight portion, Amylum Nelumbinis Rhizomatis 21 weight portions, Radix Dauci Sativae 15 weight portion, Rhizoma Dioscoreae powder 14 weight portion, Bombyx Batryticatus powder 19 weight portion, Semen Maydis oil 5 weight portion, Sal 4 weight Part, vitamin premix 0.2 weight portion, microelement pre-mix material 0.2 weight portion and Chinese medicine additive 3 weight portion.

Described Chinese medicine additive includes following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Raphani, fevervine, Fructus elaeagni glabrae, Semen Euryales, Radix Puerariae, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, Fructus Jujubae, Rhizoma Imperatae, the Radix Aucklandiae, Herba Agrimoniae, Folium Callicarpae Formosanae, wood, Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, sand Core, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus Mume, Galla Chinensis, Herba Euphorbiae Humifusae and Pericarpium Granati.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Radix Astragali 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight Part, Ganoderma 15-25 weight portion, Semen Raphani 12-20 weight portion, fevervine 12-22 weight portion, Fructus elaeagni glabrae 10-18 weight portion, Gorgon euryale Real 15-28 weight portion, Radix Puerariae 12-18 weight portion, Herb Gynostemmae Pentaphylli 9-18 weight portion, Radix Rhodiolae 10-17 weight portion, Fructus Jujubae 14-25 weight Amount part, Rhizoma Imperatae 12-21 weight portion, Radix Aucklandiae 10-19 weight portion, Herba Agrimoniae 12-19 weight portion, Folium Callicarpae Formosanae 10-18 weight portion, wood 10-15 weight portion, Radix Scutellariae 15-25 weight portion, Cortex Fraxini 10-18 weight portion, Herba Sophorae alopecuroidis 8-15 weight portion, Fructus Amomi 10-14 weight portion, Fructus Amomi Rotundus 12-19 weight portion, Fructus Tsaoko 8-15 weight portion, Radix et Rhizoma Thalictri 9-15 weight portion, Fructus Mume 12-20 weight portion, Galla Chinensis 12-19 weight Amount part, Herba Euphorbiae Humifusae 12-19 weight portion and Pericarpium Granati 10-18 weight portion.

In described Chinese medicine additive the parts by weight of each raw medicinal material be preferably: the Radix Astragali 18 weight portion, the Rhizoma Atractylodis Macrocephalae 13 weight portion, Ganoderma 21 weight portion, Semen Raphani 16 weight portion, fevervine 17 weight portion, Fructus elaeagni glabrae 14 weight portion, Semen Euryales 21 weight portion, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portion, Radix Rhodiolae 13 weight portion, Fructus Jujubae 18 weight portion, Rhizoma Imperatae 17 weight portion, the Radix Aucklandiae 15 weight Part, Herba Agrimoniae 15 weight portion, Folium Callicarpae Formosanae 14 weight portion, wooden 12 weight portions, Radix Scutellariae 21 weight portion, Cortex Fraxini 14 weight portion, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 12 weight portion, Fructus Amomi Rotundus 16 weight portion, Fructus Tsaoko 11 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Fructus Mume 16 weight portion, Galla Chinensis 16 weight portion, Herba Euphorbiae Humifusae 16 weight portion and Pericarpium Granati 14 weight portion.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the determining alcohol of 4 times It is the ethanol of 85～95%, is heated to reflux 1～3 hour, extract, filter and obtain the first extracting solution；Filter the medicinal residues obtained to add Relative to described medicinal residues quality 1～the ethanol that determining alcohol is 85～95% of 2 times, being heated to reflux 1～3 hour, extract, filtration obtains Obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, obtain Obtain 300 mesh～the micropowders of 400 mesh, it is thus achieved that Chinese medicine additive powder.

In order to preferably realize foregoing invention purpose, the invention provides a kind of mixed feed for treating gosling plague Preparation method, described preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, Semen Tritici aestivi, Oryza glutinosa, DDGS, Testa Tritici and rapeseed cake by ratio of weight and the number of copies, puts into pulverizer Carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve；

(2) batching step: according to ratio of weight and number weigh Semen phaseoli radiati powder, Amylum Nelumbinis Rhizomatis, Radix Dauci Sativae, Rhizoma Dioscoreae powder, Bombyx Batryticatus powder, Semen Maydis oil, Sal, vitamin premix, microelement pre-mix material and Chinese medicine additive, pulverize, with step (1), the fine powder obtained and mix, put into Mixer, mix homogeneously, incorporation time is 30-60s；

(3) granulation step: putting into granulator and pelletize, pelleting temperature is 85 DEG C so that it is gelatinization degree reaches more than 90%.

The invention has the beneficial effects as follows: the feedstuff of the present invention contains the Chinese medicine of the effect with invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal Additive, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill goose, there is the course for the treatment of shorter, curative effect is preferable, and prolonged application is without drug resistance Property, drug residue free, the advantages such as cost price is cheap, Chinese medicine additive and other feedstuffs cooperate, and interact, no It is only capable for the treatment of gosling plague, additionally it is possible to meet the nutritional need of young goose, be particularly well-suited to the nutritional need suffering from gosling plague young bird goose, Body also can be played certain health-care effect after eating this type of Carnis Anseris domestica by consumer.

Detailed description of the invention

Chinese medicine additive refer to China to the physical property of the Nature Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (acid, Sweet, bitter, peppery, salty) and the traditional theory of material relation is taken as the leading factor and to raise and the subjects theory such as feed industry and technology are for depending on Torr, the single and compound Chinese herbal medicine additive developed or intermixture.From modern pharmacology analysis, effectively become with Chinese herbal medicine Being divided into the feed additive of main body, have immunologic function and the non-specific antimicrobial effect of regulation body, Chinese herbal medicine contains anti- The bioactive substances such as the alkaloid of antibacterial composition, polysaccharide, two class volatile oil, organic acid flavone and bioflavonoids, exchange Joint human body immune function, good effect of improving health conditions.It is reported, ward off more have promotion thymus reaction, stimulate netted Endotheliocyte improves specific antigen respond；Alkaloid can strengthen body fluid and cellular immune function, and stimulates huge biting carefully The phagocytic function of born of the same parents, two classes can strengthen the phagocytic function of reticuloendothelial system, and can promote antibody tormation, promote that antigen-antibody is anti- Should can regulate enteral and prevent the breeding of noxious bacteria and improve the activity of enzyme with lymphocyte transformation organic acid, making animal body Intracellular metabolic can be normally carried out.Folding Chinese medicine feed additive is divided not contain only a number of battalion from the theory of modern nutriology Support material, but also containing a number of unknown growth regulator and pigment, have and activate body directly or indirectly Biochemical reaction, strengthens biosynthesis effect, thus promotes the production performance of animal.

Chinese medicine additive of the present invention is mainly theoretical according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, theory of Chinese medical science think righting and eliminating evil be mutual Two aspects of contact, hold up precisely in order to eliminating evil, by the method strengthening healthy energy, get rid of evils and go out, thus get well, i.e. so-called " just containing evil from dispelling ".Eliminating evil is for righting, eliminates the infringement of paathogenic factor and reaches to protect healthy energy, restorative purpose, I.e. so-called " heresy is gone just from peace ".Righting with eliminating evil be complementary two aspects.When therefore using the rule for the treatment of of strengthening vital QI to eliminate pathogenic factors, Conscientiously carefully analyze the contrast situation of good and evil strength, know the secondary from the primary, determine righting or eliminating evil, or determine the priority of strengthening vital QI to eliminate pathogenic factors. Generally, righting is used for deficiency syndrome；Eliminating evil for excess syndrome；If belonging to deficiency syndrome mingling with excess syndrome card, then answer strengthening vital QI to eliminate pathogenic factors use, but this double Gu is not righting and eliminating evil half and half, is the primary and secondary emergency of deficiency and excess to be distinguished, to determine the primary and secondary, successively of strengthening vital QI to eliminate pathogenic factors.Always It, should be with " righting will not stay heresy, eliminating evil just do not causing injury " for degree.

Chinese medicine additive of the present invention follows the ultimate principle of " strengthening vital QI to eliminate pathogenic factors ", it then follows invigorating the spleen and benefiting QI, the principle of removing toxic substances antidiarrheal, Providing a kind of feedstuff for treating gosling plague, it includes that Chinese medicine additive, Chinese medicine additive include following raw medicinal material: yellow Stilbene, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Raphani, fevervine, Fructus elaeagni glabrae, Semen Euryales, Radix Puerariae, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, Fructus Jujubae, Rhizoma Imperatae, the Radix Aucklandiae, Herba Agrimoniae, Folium Callicarpae Formosanae, wood, Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus Mume, Galla Chinensis, Herba Euphorbiae Humifusae and Pericarpium Granati.Wherein, Semen Raphani, fevervine, Radix Aucklandiae strengthening the spleen to promote digestion；The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Euryales, Herb Gynostemmae Pentaphylli, Fructus Jujubae, red scape My god, Herba Euphorbiae Humifusae removing toxic substances, invigorating the spleen and benefiting QI；Rhizoma Imperatae, Herba Agrimoniae, Folium Callicarpae Formosanae, wood removing toxic substances hemostasis；Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus elaeagni glabrae, Radix Puerariae heat clearing and damp drying, antidiarrheal of detoxifying；Fructus Mume, Galla Chinensis, Pericarpium Granati relieving diarrhea with astringents.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

The Radix Astragali: sweet, tepor；Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " lossless energy is sent out, and has antiperspirant for the Radix Astragali, life consolidating superficial resistance Can be only；Process with invigorating middle warmer, benefit vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rises, and yang deficiency is suitable without hot person It." " book on Chinese herbal medicine justice ": " all middle gas is depressed, and spleen soil is weak, and the clearing heat in QI system person of sinking is the most suitable for the Radix Astragali, soil, replenishing vital QI with drugs of warm nature taste in tonification.Its Skin goes directly the skin table muscle of people, and solid protection defends sun, and substantial table divides, and is its speciality, so all diseases of exterior deficiency, god's agent the most." function consolidating superficial resistance Arresting sweating, inducing diuresis to remove edema, holds in the palm skin ulcer evacuation of pus, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, Can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous；The nonspecific immunity of body can be improved Power, protects the liver and drops hypoglycemic effect, and staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had suppression Effect.The Radix Astragali can appreciable impact splenocyte Information Conduction, it is achieved immunoregulation effect.Can be used for hypertension, ischemic Heart disease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the merit that activating the spleen is moisturized Effect, cures mainly the feeling of fullness diarrhoea caused by dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema；The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, Proctoptosis with chronic dysentery；The card such as solid, sweating due to debility spontaneous perspiration in the playing of deficiency of the spleen causing weakness of QI, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, and the absorption strengthening small intestinal is made With, gastrointestinal function is had regulation effect.There is obvious and lasting diuresis, various animals such as rat, rabbit, Canis familiaris L. are had work With.To not anaesthetizing Canis familiaris L. intravenous injection decoct 0.05-0.25g/kg, urine volume increases up to more than 9 times, and after medication 5 hours still Higher than normal.The Rhizoma Atractylodis Macrocephalae has obvious inhibitory action to platelet aggregation, in Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg gavage l-4 week, can significantly extend The time of rat prothrombing.The Rhizoma Atractylodis Macrocephalae has vasorelaxation action.It is inhibitory action to heart, can cause when dosage is excessive to stop winning, fiber crops Liquor-saturated dog intravenous injection decoct 0.1g/kg, when blood pressure slightly declines 0.25g/kg, blood pressure drastically declines, and has no extensive in 3-4 hour Multiple.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, pant, have a sleepless night, dyspepsia, pernicious Tumor etc..Animal pharmacology shows experiment: nervous system is had inhibitory action, blood circulation have blood pressure lowering and strengthen heart receipts by Ganoderma The effect of contracting power, has phlegm-dispelling functions to respiratory system, additionally, also hepatoprotective, raising immunologic function, antibacterial grade acts on.

Semen Raphani: property is put down, acrid in the mouth, sweet；Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, gastral cavity abdomen Distension, belch, weight, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest after dysentery.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, Expectorant heap soil or fertilizer over and around the roots is breathed with cough.Entering spleen, stomach, lung meridian, can help digestion de-swelling, and effect is notable, has the title of " rush wall fall wall ".Clinic is commonly used in treatment real (food, wet, stagnant) is demonstrate,proved.But, these product the most only help digestion de-swelling, to deficiency syndrome with it, obtain effect the best, because of its property peace, its Abnormal smells from the patient is the highest, the fraud of unbiased victory, and can not be limited to " rush wall fall wall " says there is the suspicion (being having a surplus of flat gas actually) of dispelling the stagnated QI, and Give it up.Semen Raphani water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water extract has significantly Hypotensive effect, for anesthetized rabbit, cat and dog, all can cause animal blood pressure to decline during intravenous injection.

Fevervine: property is put down, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head controls new internal injury, pot meat, qi-restoratives kidney tonifying, removes Fire is enriched blood；Washing skin ulcer pain relieving, the heat that disappears dissipates poison.Its leaf beats rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " for wash, removing toxic substances, go Wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens Pain, dysentery of suffering from diarrhoea, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury damages Wound.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain Sedation.Fevervine total alkaloids can suppress myenteron to shrink, and the myenteron contracture that energy is caused by antagonism acetylcholine.Fevervine is decocted Agent has inhibitory action to S. aureus in vitro and Shigella flexneri, and extractum is to staphylococcus aureus and pneumonia streptococcus Bacterium also has bacteriostasis.

Fructus elaeagni glabrae: acid；Flat.Return large intestine channel.Function cures mainly: astringing to arrest diarrhea；Dysentery relieving.Main enteritis；Diarrhoea；Dysentery.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, the function of damp eliminating leukorrhagia stopping, cure mainly Emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, carry inferior card.

Radix Puerariae: sweet, pungent is cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For diseases caused by exogenous pathogenic factor Fever and headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；Hypertension neck pain.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature；Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, only Cough and eliminate the phlegm.After small number of patients is taken medicine, the symptoms such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus occur.Clothes strand After stock basket, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time hungered and thirst, and not only treats constipation but also control loose stool.Excited to cerebral cortex and The reaction of suppression can keep suitable balance, and nervus centralis is had dual regulation.There is excellent analgesia, sleeping, anti-tight The effect opened.On the basis of reducing myocardial wall anxiety, relaxing cerebrovascular and peripheral vascular resistance, heart and brain vigor can be strengthened, add Big coronary flow, relaxes arteriosclerosis, promotes overall circulation more vigorous and smooth.It is demonstrated experimentally that not diet rich and Taking Herb Gynostemmae Pentaphylli group, refuse to obey Herb Gynostemmae Pentaphylli group with avoiding meat, make regular check on and compare, internal gallbladder is solid close with neutral fat content.Thus may be used See that Herb Gynostemmae Pentaphylli has benign transformed regulation effect to body fat mass in human body.Taking Herb Gynostemmae Pentaphylli to compare with the mouse of disobedience, its swimming time is about Long 31-57%, and antisecosis is the most faster, after people takes Herb Gynostemmae Pentaphylli, muscle power energy is more abundant, indefatigability, though tired It is also easy to recover, thus work efficiency increases.Human body part function is weak, Cucumber can be produced allergy, and be formed The diseases such as bronchus is panted, skin rashes, arthralgia, Herb Gynostemmae Pentaphylli is rather good to these sick effects.

Radix Rhodiolae: sweet, bitter, flat；Return lung, heart channel.Radix Rhodiolae is dry root and the root of crassulaceae plants Radix Rhodiolae Stem, effect of Radix Rhodiolae and effect be can the kidney invigorating, regulate the flow of vital energy and nourish blood, have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the merit under leukorrhagia stopping Effect, the side effect of Radix Rhodiolae does not the most find.Radix Rhodiolae can improve sleep, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, invigorate blood circulation Hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyretic bring down a fever, nourish the effects such as vigour；It is used for outward treating traumatic injury and burn and scald.Grind Study carefully and point out that Oxidation, in a lot of advancing of disease processes, plays highly important role, such as cancer, cardiovascular diseases, sugar Urine disease, nerve degeneration and rheumatoid arthritis etc..In traditional medicine, Radix Rhodiolae is also for treating diabetes.Relevant experiment Utilizing mouse to make object, test Radix Rhodiolae is movable to controlling the glycemic index of type-II diabetes, ferment and some antioxidative.

Fructus Jujubae: have immunosuppressive action, the ethanol extract of Fructus Jujubae to rat oral gavage, shows Fructus Jujubae and sulfur with 100mg every day Azoles purine has same immunosuppressant；Atopic diseases can be suppressed the generation of antibody.Fructus Jujubae ethanol extract may be to greatly Mus reactive antibody has inhibitory action, and non-reacted antibody does not produce other effects of inhibitory action: the flavone in Fructus Jujubae Double glucoside A, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has increases the effect of cAMP in leukocyte. Fructus Jujubae decoct can reduce the CCl4 damage to Rabbit Liver.The swimming time of mice can be extended.Report Fructus Jujubae has suppression cancer recently The proliferation function of cell.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, bladder warp." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, cloth Ground such as pin, between custom, the thatch pin of meaning, also can eat, very benefit children's.Xia Sheng spends in vain, fine so, withered to the autumn, its root is to pure the whitest, the most very Sweet and refreshing, adopt root June and use." Compendium of Material Medica: " the emesis all blood of nosebleed, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." Having the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has the haematemesis of accumulated heat, hemoptysis, and damp invasion of lower energizer pents up the urine of bladder Blood, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, jaundice due to damp-heat etc. is demonstrate,proved.Rhizoma Imperatae decoct and water logging agent gavage, and normal rabbits is had diuresis Effect, is administered 5-10 days, and diuresis is the most obvious.Fu Shi and sonne bacillus are in vitro had bright by Rhizoma Imperatae decoct Aobvious inhibitory action, but to will Hayes and the nothing effect of easypro Shigella flexneri.The Coixol contained by the Rhizoma Imperatae receipts to skeletal muscle Contracting and metabolism have inhibitory action.

The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For Breast gastral cavity distending pain, weight after dysentery, food stagnation does not disappears, anorexia.Radix Aucklandiae (roasted) reality intestinal antidiarrheal.For stomachache of having loose bowels.

Herba Agrimoniae: bitter in the mouth, puckery, property puts down, GUIXIN, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or front or rear, red and white leukorrhea Under, the cold stomachache in face, the most red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, and manages all kinds of diseases and ailments, dissipates feeling of fullness；Traumatic injury is spitted blood, metrorrhagia, dysentery, Discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.It is widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, cough up Blood, epistaxis, dysentery, impairment caused by overstrain takes off the cards such as power, carbuncle, traumatic injury, wound hemorrhage.

Folium Callicarpae Formosanae: pungent, bitter, flat.Return liver, spleen, stomach warp.Dissipating blood stasis stops blooding, reducing swelling and alleviating pain.Leaf: be used for spitting blood, spitting of blood, epistaxis, Have blood in stool；External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.Supplement to the Herbal: " solve all poisonous substances, carbuncle, sore throat, poison Swollen, lower flaccidity, Serpentis a poisonous snake mentioned in ancient books bugbites, mad dog poison, and liquor clothes;Also liquor wash skin ulcer swell, except the long skin of blood." " illustrated handbook planted by middle traditional Chinese medicines ": " to food Road venous hemorrhage, intestine gastric ulcer is hemorrhage, epistaxis, and wound hinders, pneumorrhagia and have tooth pulled out and hemorrhage all have good effect." Folium Callicarpae Formosanae has Promote the effect of blood coagulation, intestinal blood vessel is had direct contraction and rises indirectly by intestinal tube contracture compressing stifled resistance blood vessel Anastalsis.Folium Callicarpae Formosanae all has difference to escherichia coli, shigella flexneri, staphylococcus aureus, Hemolytic streptococcus etc. The inhibitory action of degree.Folium Callicarpae Formosanae can make bleeding time and reduced clotting time, its hemostasis principle be probably its make vasoconstriction and Platelet count is made to increase.

Wood: bitter, puckery is flat.Return liver, stomach, large intestine channel.Astringing to arrest bleeding, heat-clearing and toxic substances removing, antidiarrheal.Root, leaf, flower, fruit are used as medicine, Can antipyretic, hemostasis, dredge the meridian passage；Timber is solid durable；Core and leaf, containing tannin, can carry mimosa extract.This product is puckery to be restrained, and has preferably Astringing to arrest bleeding effect, can be used for multiple hemorrhagic condition.This product can hemostasia and promoting granulation, again can heat-clearing and toxic substances removing, available harness the river burning hot Wound.This product is pained, function astringing to arrest diarrhea, cure mainly have loose bowels, dysentery.Mixture and the cured leaf powder of leaf all have anastalsis；Contained yellow Ketone can strengthen coronary flow, and has heart tonifying, expansion peripheral blood vessel effect；Experiment in vitro shows, this product is to streptococcus, Fructus Vitis viniferae ball Bacterium, typhoid fever and escherichia coli all have inhibitory action.

Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri is optimal, so Table can not be reached by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can drop, and so house Radix Scutellariae can not go up refresh oneself.So Fang Mai section with clear flesh Bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section with antiabortive reason warp, this Gai Zhu section half table is partly First of in, agent is also." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot painful abdominal mass Full, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae has antipyretic, calm, fall The effects such as blood pressure, diuresis, reduction capillary permeability, suppression intestinal motility, to staphylococcus, blood dissolubility streptococcus, pneumonia Diplococcus, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus have certain inhibitory action, to upper respiratory tract infection, slowly Property bronchitis, bacillary dysentery etc. have preferable curative effect.

Cortex Fraxini: bitter in the mouth, cold；Return Liver Channel, gallbladder meridian, large intestine channel." book on Chinese herbal medicine converges and says ": " Cortex Fraxini, bitter in the mouth is puckery and hard, can restrain The vital essence wandered away.Therefore Zhong Jing Radix Pulsatillae Decoction, control the inferior burnt deficiency-heat and profit person with this, take hardship with puckery meaning also." " book on Chinese herbal medicine guiding principle Mesh ": " skin, color clearing heat in QI system is cold, and bitter in the mouth is puckery, is to faint cloudy liver, few sun gallbladder meridian medicine also.Therefore control mesh disease, infantile convulsion, take its flat wood also； Control the inferior dysentery, metrorrhagia and leukorrhagia, take its astringent therapy also；The few essence smart, beneficial of man can be controlled again and have son, all take it puckery and have benefit also." " legendary god of farming's book on Chinese herbal medicine Warp ": " heat extraction, blue or green nebula tunica albuginea in mesh." function heat clearing and damp drying, liver heat removing and eyesight improving, astringent therapy dysentery relieving, leukorrhagia stopping.For pyretic toxicity dysentery, leukorrhagia Pudendal pruritus, liver-heat conjunctival congestion and swelling pain, the raw cataracta of mesh.

Herba Sophorae alopecuroidis: nature and flavor are bitter, cold, poisonous.Heat clearing and damp drying, pain relieving, parasite killing.Cure mainly damp and hot dysentery of letting out, leukorrhagia, ulcer Deng.The total alkaloid of sophora alopecuroide extracted from herb has antiinflammatory, anticancer, antiallergic action, anti-arrhythmia, antiulcer, rising Leukocyte, relieving asthma, antipyretic, parasite killing, calmness, analgesia, the effect such as antiviral.The pharmacological action of Alkaloids From Sophora Alopecuroides L: 1. to maincenter Neural effect, is embodied in tranquilizing soporific, eases pain and lower the temperature；2. the effect to cardiovascular system, is embodied in the anti-rhythm of the heart and loses Often, positive inotropic action, blood pressure lowering and reduce heart rate function, to myocardial ischemia and the protective effect of infraction, effect for reducing blood fat；3. resist Virus, antiinflammatory and immunosuppressive action, Radix Sophorae Flavescentis total alkaloids can suppress multiple virus breeding. strengthen immunoloregulation function and immunological enhancement Effect；4. antitumor action, obvious to hepatoma carcinoma cell inhibitory action, cervical cancer, lymphosarcoma, pulmonary carcinoma also there are is inhibitory action； 5. the effect to smooth muscle, total alkali and some monosomic alkali all can resist the Contraction of The Ileum From A White induced by inflammatory mediator, right Bronchial smooth muscle has relexation, also has effect to block mold.

Fructus Amomi: acrid in the mouth, warm in nature；Return spleen channel, stomach warp, kidney channel.Materia Medica of Decoction: " contracting sand, with Symplocoris Paniculatae, Fructus Amomi Rotundus for making, enters Lung, with Radix Ginseng, Fructus Alpiniae Oxyphyllae for making, enters spleen, with Cortex Phellodendri, Poria for making, enters kidney, with red, Kaolin for making, enters large and small intestinal.” " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For wet Turbid middle resistance, gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.The pungent scattered temperature of these product is led to, fragrant, its Removing dampness is amusing, and the effect of circulation of qi promoting warming middle-JIAO is the best, and ancients say it: " for tune stomach key medicine of being amusing." therefore the caused gastral cavity abdomen of all dampness or the stagnation of QI The all cards of the incoordination between the spleen and stomach such as distending pain are commonly used, and especially cold-damp stagnation of QI person is most widely suited.

Fructus Amomi Rotundus: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is warming middle-JIAO astringing intestine to stop diarrhea, effect that circulation of qi promoting helps digestion, for void Rush down, cold-dysentery, abdominal distention, lack of appetite are vomitted, dyspepsia does not disappear etc. is demonstrate,proved.Methyleugenol in this product volatile oil and elemicine are to little Mus, rabbit, cat and Canis familiaris L., iv has anesthetic action after being administered.Mouse Uterus cancer that MCA and DMBA is induced by Semen Myristicae and dermal papilla shape Tumor has inhibitory action.Volatile oil contained by these product has stimulation to gastrointestinal tract, and has the effect of dispeling the wind.Myristicin is to normal person There is hallucinogenic action, the brain of people is had moderate excitation.Semen Myristicae and myristicin all can strengthen the effect of tryptamines.

Fructus Tsaoko: acrid in the mouth, warm in nature, nontoxic；Enter spleen channel, stomach warp.Compendium of Material Medica: " Fructus Tsaoko, use same with the Rhizoma Anemarrhenae are controlled subtertian malaria and trembled with fear Heat, takes the evil of its monoyin and monoyang unbiased victory, and it is cold that lid Fructus Tsaoko controls lunar only victory, and the fire that Rhizoma Anemarrhenae Zhi Yangming solely wins is also." " herbal classic is met Former ": " except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on profit diaphragm, solve wheaten food, fish, all poison of meat." dampness is except cold, eliminate the phlegm preventing the attack (or recurrence) of malaria, digestion-promoting Food.Cure mainly malaria, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.Join the Rhizoma Anemarrhenae, there are tune cold and heat, and the exterior and the interior it Merit, kind treating malaria card.

Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Controlling damp-heat dysentery, jaundice, calentura is irritated, cough due to lung-heat, Ulcerative carbuncle toxic swelling, conjunctival congestion and swelling pain.Now it is applied to enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.Non-for fixed Alkali has hypotensive effect, and its crude preparation by using can control hypertension.Magnoflorine, berberine, jateorhizine etc. see Radix Aristolochiae, Rhizoma Coptidis bar.With Platymiscium Radix thalictri petaloidei Thalictrumpetaloideum or T.simplex T.simplex contains thalcimine (Thalsimine), animal is had antiinflammatory, analgesia, cooling effect. purple meadowrue (Thalictrum dasycarpum) T.Dasycarpum card product alkali Han Thalictrum aquilegifolium L. var. sibiricum Regel (Thalicarpine), purple meadowrue (Thalictrum dasycarpum) alkali (Thalidasine), thalfetidine, to rat watt g cancer 1 and Mice Bearing Lewis Pulmonary carcinoma is effective.Thalictrum aquilegifolium L. var. sibiricum Regel card product alkali also has weak hypotensive effect.

Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, enter liver, lung, spleen, large intestine channel, supplement to the Herbal: " going expectorant, main malaria miasma, quench the thirst tune In, except cold and hot dysentery, emesis is inverse." " Japan hanako materia medica ": " except labor, controlling hectic fever due to YIN-deficiency, remove unhappiness, relieving dysentery with astringents, disappear alcoholism, controls hemiplegia skin Skin is benumbed, and removes stain, makes us sleeping.Enter to build again tea, Rhizoma Zingiberis is ball, only chronic dysentery with frequent relapse." have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, promote the production of body fluid Effect, is used for treating chronic dysentery more than, damp-heat dysentery, has blood in stool, hematuria, the card such as snowslide.Fructus Mume has the function of sterilization, is also prevented from food Degenerate in the intestines and stomach.Malic acid in Fructus Mume directs into large intestine appropriate moisture, forms feces and excretes.When blood is clean During change, metabolism just strengthens, and health can recover energy naturally.Citric acid in Fructus Mume helps to absorb vitamin and ferment, Also can prevent disease and allaying tiredness.

Galla Chinensis: sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, Compendium of Material Medica: " pathogenic fire reducing of astringing the lung, reduce phlegm drink, cough-relieving Cough, quench one's thirst, night sweat, vomiting, lose blood, chronic dysentery, jaundice, cardiac and abdominal pain, the nocturnal fretfulness in infants, control eye red wet rotten, detumescence poison, sore throat, hold back routed Skin ulcer, incised wound, receive under proctoptosis, sub-intestinal pendant." there is hidroschesis of astringing the lung, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, effect of hemostasis removing toxic substances, cure mainly chronic cough of deficiency lung, from Antiperspirant night sweat, chronic dysentery chronic diarrhea, proctoptosis, seminal emission, nebulousurine, various hemorrhage, carbuncle furuncle etc. are demonstrate,proved.Owing to tannic acid contained therein is to albumen Matter has Galla Chinensis (figure seven) precipitation, and after skin, mucosa, ulcer contact tannic acid, its tissue protein is i.e. solidified, and causes one Layer tunicle and in astriction, the most oppressed contraction of thin vessels simultaneously, blood clotting and play hemostasia effect.In vitro tests is to golden yellow Color staphylococcus, streptococcus, streptococcus pneumoniae and typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, bacillus pyocyaneus etc. all have significantly Antibacterial or bactericidal action.Tannic acid can form insoluble complex with a lot of heavy metal ion, alkaloid and glycoside, therefore can be used as Chemical antidote.

Herba Euphorbiae Humifusae: pungent, flat.Return liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, cough Blood, hematuria, have blood in stool, metrorrhagia, furuncle carbuncle.

Pericarpium Granati: sour in the mouth, puckery, warm in nature；Enter large intestine, kidney channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control with the passing of time watery diarrhea, simmer clothes with frying Saccharum Sinensis Roxb., Control again dysentery pus and blood, large intestine hematochezia.Decoct with Fructus Aristolochiae and control children's infantile malnutrition worm.And wash bladder." " detailed outline ": " and antidiarrheal dysentery, hematochezia, proctoptosis, Metrorrhagia leukorrhagia." there is relieving diarrhea with astringents, effect of hemostasis parasite killing, for chronic diarrhea chronic dysentery, discharging fresh blood stool, bleeding not during menses, abdominal pain due to worm stagnation Deng card, Pericarpium Granati has stronger inhibitory action to escherichia coli.Pericarpium Granati containing many containing mixing matter, when them and mucosa, wound surface etc. After contact, can precipitate or solidify the protein of local, make to be formed on surface comparatively dense protective layer, contribute to local woanded surface more Close or protection local is from stimulation.Matter of mixing is the effective ingredient of Pericarpium Granati anti-genitals herpus vivus, and its feature can not only press down System virus is in intracellular propagation, and what is more important shows stronger directly killing virus and stop and the work of adherent cell With.

Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese medicine additive

Take the Radix Astragali 18 weight portion, the Rhizoma Atractylodis Macrocephalae 13 weight portion, Ganoderma 21 weight portion, Semen Raphani 16 weight portion, fevervine 17 weight Part, Fructus elaeagni glabrae 14 weight portion, Semen Euryales 21 weight portion, Radix Puerariae 15 weight portion, Herb Gynostemmae Pentaphylli 14 weight portion, Radix Rhodiolae 13 weight portion, Fructus Jujubae 18 weight portion, Rhizoma Imperatae 17 weight portion, the Radix Aucklandiae 15 weight portion, Herba Agrimoniae 15 weight portion, Folium Callicarpae Formosanae 14 weight portion, wooden 12 weights Amount part, Radix Scutellariae 21 weight portion, Cortex Fraxini 14 weight portion, Herba Sophorae alopecuroidis 11 weight portion, Fructus Amomi 12 weight portion, Fructus Amomi Rotundus 16 weight portion, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 12 weight portion, Fructus Mume 16 weight portion, Galla Chinensis 16 weight portion, Herba Euphorbiae Humifusae 16 weight portion and Pericarpium Granati 14 Weight portion.

Preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, and addition relative to the determining alcohol of mixture quality 3 times is The ethanol of 90%, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained to add relative to institute State the ethanol that determining alcohol is 90% of medicinal residues quality 1.5 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；By One extracting solution and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；

Second step, is placed in super micron mill pulverizing 1.5 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that The micropowders of 350 mesh, it is thus achieved that Chinese medicine additive powder.

Embodiment 2 feedstuff

Embodiments provide a kind of feedstuff for treating gosling plague, the parts by weight of each raw material in feedstuff For: Semen Maydis 46 weight portion, Semen Tritici aestivi 31 weight portion, Semen setariae 18 weight portion, Oryza glutinosa 23 weight portion, DDGS 12 weight portion, Testa Tritici 25 weight Amount part, rapeseed cake 21 weight portion, Semen phaseoli radiati powder 12 weight portion, Amylum Nelumbinis Rhizomatis 21 weight portion, Radix Dauci Sativae 15 weight portion, Rhizoma Dioscoreae powder 14 weight portion, deadlock Silkworm powder 19 weight portion, Semen Maydis oil 5 weight portion, Sal 4 weight portion, vitamin premix 0.2 weight portion, microelement pre-mix material 0.2 weight portion and Chinese medicine additive 3 weight portion；Wherein Chinese medicine additive is the Chinese medicine additive powder of embodiment 1.

Its preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, Semen Tritici aestivi, Oryza glutinosa, DDGS, Testa Tritici and rapeseed cake by ratio of weight and the number of copies, puts into pulverizer Carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve；

(2) batching step: according to ratio of weight and number weigh Semen phaseoli radiati powder, Amylum Nelumbinis Rhizomatis, Radix Dauci Sativae, Rhizoma Dioscoreae powder, Bombyx Batryticatus powder, Semen Maydis oil, Sal, vitamin premix, microelement pre-mix material and Chinese medicine additive, pulverize, with step (1), the fine powder obtained and mix, put into Mixer, mix homogeneously, incorporation time is 30-60s；

(3) granulation step: putting into granulator and pelletize, pelleting temperature is 85 DEG C so that it is gelatinization degree reaches more than 90%.

The toxicity test of Chinese medicine additive:

1, trial drug

Choose Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 13g, Ganoderma 21g, Semen Raphani 16g, fevervine 17g, Fructus elaeagni glabrae 14g, Semen Euryales 21g, Radix Puerariae 15g, Herb Gynostemmae Pentaphylli 14g, Radix Rhodiolae 13g, Fructus Jujubae 18g, Rhizoma Imperatae 17g, Radix Aucklandiae 15g, Herba Agrimoniae 15g, Folium Callicarpae Formosanae 14g, wood 12g, Radix Scutellariae 21g, Cortex Fraxini 14g, Herba Sophorae alopecuroidis 11g, Fructus Amomi 12g, Fructus Amomi Rotundus 16g, Fructus Tsaoko 11g, Radix et Rhizoma Thalictri 12g, Fructus Mume 16g, five times Sub-16g, Herba Euphorbiae Humifusae 16g and Pericarpium Granati 14g mixing, be ground into powder；Immersion 25 in powder addition 1400g cold water will be obtained little Time, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue；Filtration is obtained Filtering residue again add in 1400g cold water, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the Two filtrates；Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, gives in the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg) The decoction of medicine additive, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female are each Half), remaining 1/2 animal lives after continuing to observe 2 weeks and kills.The outward appearance of animal, general behavior, food ration, body weight is observed during test Change, is administered latter 90 days and drug withdrawal carries out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood for 2 weeks Biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, pathological tissue Etc. index checking.Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, Outward appearance sign, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups and matched group hematological examination, Blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination Show no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively clinical medicine dose 180,60,20 times, according to the Chinese medicine preparation of the result of the test present invention high, medium and low three dosage (18.0,6.0,2.0g raw Medicine/kg) within continuous 90 days, it is administered rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes also Having no retardance toxic reaction, the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.

Contrast test

Liaocheng of Shandong Province goose plant, in by the end of December, 2012, finds that food in various degree occur in nearly 450 young geese It is intended to depressed, down in spirits, the phenomenon of feather pine unrest, flows out serosity nose liquid with nostril, draw lark loose stool, even occur dead Die young goose, and young for death goose is dissected visible liver enlargement, and in kermesinus, matter is crisp frangible, at the small intestinal of yolk suspensor Yu ileocecus Section, outward appearance is expanded, and intestinal mucosa is congested, and inflammation necrosis comes off, with the embolus that fibrinous exudate is frozen into about 3cm.According to Above-mentioned epidemiology is diagnosed as gosling plague with analysing.

Choose the ill young goose 200 that 2 week old are made a definite diagnosis, 200 ill geese are randomly divided into two groups, respectively embodiment group And matched group, the ill goose of two groups all without significant difference, has comparability at the aspect such as body weight, the state of an illness.Embodiment group and comparison Group uses the feedstuff of the embodiment of the present invention 2 and conventional feed to feed ill goose respectively, feeds continuously 7 days, and wherein, matched group also needs Carry out conventional therapy i.e. subcutaneous injection hyper-immune serum 0.2 milliliter.Each group of ill goose body weight, period record is weighed respectively before and after experiment The recovery from illness situation of ill goose and death toll, calculate average daily gain and cure rate, and result is as shown in Table 1 and Table 2.Wherein, control More: spirit is normal, drinking-water of searching for food is normal, and feces is normal, bouncing, and the groups such as inspection liver, intestinal, fabricius bursa, pancreas are cutd open in sampling Knit organ normal；Invalid: clinical symptoms is not improved and even increased the weight of or dead.

1 liang of experimental group young bird goose average weight synopsis of table

Knowable to the data of table 1: compared with matched group, use the young goose of forage feed of the present invention, when feeding to 3 week old, Its average weight exceeds 83.5g than the young goose that conventional feed is fed, and average daily gain exceeds 11.95g/d.

The therapeutic effect synopsis of 2 liang of experimental group young bird geese of table

Knowable to the data of table 2: compared with conventional medicament, the feedstuff of the embodiment of the present invention 2 has in terms for the treatment of gosling plague Effective in cure notable, cheap, the advantage that has no side effect.

By contrast test: ill young goose average weight, the cure rate that the mixed feed of the embodiment of the present invention 2 is fed Be superior to matched group, i.e. the feedstuff of the present invention can not only treat gosling plague, additionally it is possible to meets the nutritional need of young goose, the suitableeest For suffering from the nutritional need of gosling plague young bird goose.

Model case

More than 100 young geese are gone out by the young goose of 300 14 ages in days of in January, 2014 Taian Shandong foster goose smallholder operating Existing down in spirits, be slow in action, the symptom such as loss of appetite, defecation yellow green loose stool, select a wherein seriously ill young goose to dissect, send out Existing little enteral is full of linen embolus shape thing.Take the pathological material of diseases such as the ill young heart of goose, liver, spleen and shred grinding, use sterile physiological salt Water is made 1: 5 and is diluted to suspension, after adding penicillin and streptomycin process, is inoculated in the goose embryo chorioallantoic cavity of 14 ages in days, often Goose embryonic breeding kind 0.5ml, after 3-5 days, goose embryo is dead, cuts open the dead goose embryo of inspection, finds goose idiosome villous allantoic cavity edema, whole body skin Skin is congested, hemorrhage and edema, is diagnosed as acute gosling plague.Immediately young goose symptom do not occur is isolated raising place.Choosing Taking 50 ill young geese therein, start to feed the feedstuff of the embodiment of the present invention 2, feed 7 days, within the 2nd day, ill young goose symptom is bright Aobvious improvement, within the 3rd day, 50 young geese are all fully recovered, and after continuing to feed 4 days, compared with health young bird goose, average weight is essentially identical.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (5)

1. for treating the mixed feed of gosling plague, it is characterised in that described feedstuff is made up of the raw material of following parts by weight: beautiful Rice 30-60 weight portion, Semen Tritici aestivi 20-40 weight portion, Semen setariae 15-20 weight portion, Oryza glutinosa 15-30 weight portion, DDGS 10-15 weight Part, Testa Tritici 20-30 weight portion, rapeseed cake 15-25 weight portion, Semen phaseoli radiati powder 10-15 weight portion, Amylum Nelumbinis Rhizomatis 10-30 weight portion, Radix Dauci Sativae 10- 20 weight portions, Rhizoma Dioscoreae powder 10-20 weight portion, Bombyx Batryticatus powder 10-30 weight portion, Semen Maydis oil 3-7 weight portion, Sal 2-5 weight portion, dimension Raw element premix material 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-5 weight portion；

Described Chinese medicine additive is made up of the raw medicinal material of following weight ratio: Radix Astragali 15-25, Rhizoma Atractylodis Macrocephalae 10-15, Ganoderma 15-25, Lay Fu 12-20, fevervine 12-22, Fructus elaeagni glabrae 10-18, Semen Euryales 15-28, Radix Puerariae 12-18, Herb Gynostemmae Pentaphylli 9-18, Radix Rhodiolae 10- 17, Fructus Jujubae 14-25, Rhizoma Imperatae 12-21, Radix Aucklandiae 10-19, Herba Agrimoniae 12-19, Folium Callicarpae Formosanae 10-18, wood 10-15, Radix Scutellariae 15-25, Cortex Fraxini 10-18, Herba Sophorae alopecuroidis 8-15, Fructus Amomi 10-14, Fructus Amomi Rotundus 12-19, Fructus Tsaoko 8-15, Radix et Rhizoma Thalictri 9-15, Fructus Mume 12-20, Galla Chinensis 12-19, Herba Euphorbiae Humifusae 12-19 and Pericarpium Granati 10-18.

Mixed feed for treating gosling plague the most according to claim 1, it is characterised in that each raw material in described feedstuff Parts by weight be: Semen Maydis 46 weight portion, Semen Tritici aestivi 31 weight portion, Semen setariae 18 weight portion, Oryza glutinosa 23 weight portion, DDGS 12 weight Part, Testa Tritici 25 weight portion, rapeseed cake 21 weight portion, Semen phaseoli radiati powder 12 weight portion, Amylum Nelumbinis Rhizomatis 21 weight portion, Radix Dauci Sativae 15 weight portion, Rhizoma Dioscoreae powder 14 weight portions, Bombyx Batryticatus powder 19 weight portion, Semen Maydis oil 5 weight portion, Sal 4 weight portion, vitamin premix 0.2 weight portion, trace Element premix material 0.2 weight portion and Chinese medicine additive 3 weight portion.

Mixed feed for treating gosling plague the most according to claim 1, it is characterised in that in described Chinese medicine additive The weight ratio of each raw medicinal material is: the Radix Astragali 18, the Rhizoma Atractylodis Macrocephalae 13, Ganoderma 21, Semen Raphani 16, fevervine 17, Fructus elaeagni glabrae 14, Semen Euryales 21, Radix Puerariae 15, Herb Gynostemmae Pentaphylli 14, Radix Rhodiolae 13, Fructus Jujubae 18, Rhizoma Imperatae 17, the Radix Aucklandiae 15, Herba Agrimoniae 15, Folium Callicarpae Formosanae 14, wood 12, Huang A kind of reed mentioned in ancient books 21, Cortex Fraxini 14, Herba Sophorae alopecuroidis 11, Fructus Amomi 12, Fructus Amomi Rotundus 16, Fructus Tsaoko 11, Radix et Rhizoma Thalictri 12, Fructus Mume 16, Galla Chinensis 16, Herba Euphorbiae Humifusae 16 and Pericarpium Granati 14.

4. according to the mixed feed for treating gosling plague described in any one of claim 1-3, it is characterised in that described Chinese medicine The preparation method of additive comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2～4 times is 85 ～the ethanol of 95%, it is heated to reflux 1～3 hour, extracts, filter and obtain the first extracting solution；Filter the medicinal residues obtained to add relatively In described medicinal residues quality 1～the ethanol that determining alcohol is 85～95% of 2 times, it is heated to reflux 1～3 hour, extracts, filter acquisition the Two extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300 Mesh～the micropowders of 400 mesh, it is thus achieved that Chinese medicine additive powder.

5., according to the preparation method of the mixed feed for treating gosling plague described in any one of claim 1-4, its feature exists In, described preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, Semen Tritici aestivi, Oryza glutinosa, DDGS, Testa Tritici and rapeseed cake by ratio of weight and the number of copies, puts into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing；

(2) batching step: weigh Semen phaseoli radiati powder, Amylum Nelumbinis Rhizomatis, Radix Dauci Sativae, Rhizoma Dioscoreae powder, Bombyx Batryticatus powder, Semen Maydis oil, food according to ratio of weight and number Salt, vitamin premix, microelement pre-mix material and Chinese medicine additive, pulverize, with step (1), the fine powder obtained and mix, and puts into mixed Conjunction machine, mix homogeneously, incorporation time is 30-60s；

(3) granulation step: putting into granulator and pelletize, pelleting temperature is 85 DEG C so that it is gelatinization degree reaches more than 90%.