CN102805825A - Drug for curing cutaneous pruritus and preparation method thereof - Google Patents
Drug for curing cutaneous pruritus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug for curing cutaneous pruritus and a preparation method thereof. The drug is mainly prepared by adopting polygonum multiflorum, flower of Chinese scholartree, manyleaf paris rhizome, fried fructus aurantii, salvia miltiorrhiza, prepared rehmannia roots, zaocys dhumnade, gentiana macrophylla and black sesame according to a certain weight ratio. The drug performs the functions of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, diminishing inflammation and relieving itching, is used for curing the cutaneous pruritus and has the advantages of quick effectiveness, short treatment course, no relapse and high cure rate.
Description
Technical field
The present invention relates to a kind of medicine of treating skin pruritus and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Skin pruritus is meant no former breakout, but a kind of dermatosis of pruritus is arranged, and the traditional Chinese medical science is referred to as pruritus caused by wind pathogen.Skin pruritus belongs to neural spirituality dermatosis, is a kind of skin neurosis illness.To have only skin pruritus clinically and not have the primary cutaneous impairer and be referred to as pruritus.The category that belongs to the traditional Chinese medical science " pruritus ".At present, western medicine skin pruritus poor effect, and more side effect is arranged, therefore, there is great demand in people to the Chinese medicine of effective treatment skin pruritus.
Summary of the invention
The inventor has found the medicine of effective treatment skin pruritus finally, thereby has accomplished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
The object of the invention just provides a kind of composition of medicine that can treat skin pruritus.
Another object of the present invention has just provided the method for preparing of this composition of medicine.
Medicine of the present invention selects Radix Polygoni Multiflori, Flos Sophorae, Rhizoma Paridis, Fructus Aurantii (parched), Pericarpium Citri Reticulatae, Rhizoma Imperatae, Semen Ziziphi Spinosae (parched), Periostracum Cicadae, Cortex Cinnamomi, Radix Ophiopogonis, Fructus Mori, Radix Gentianae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, Poria cum Radix Pini, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Zaocys, Radix Gentianae Macrophyllae and Semen Sesami Nigrum to make up; With these drug regimens; Make each efficacy of drugs produce synergism, thereby can effectively treat the recurrence of skin pruritus.Wherein select for use Radix Polygoni Multiflori to be because its nature and flavor are bitter, sweet, puckery, warm, return liver, the heart, kidney channel, invigorating the liver and kidney is arranged, benefiting essence-blood, black beard and hair, the function of bone and muscle strengthening is controlled blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, the chronic malaria body is empty.Select for use Flos Sophorae to be because its nature and flavor are bitter, liver, large intestine channel are gone in cold, and heat clearing away is arranged, removing heat from blood, and the hemostatic function is controlled discharging fresh blood stool, hemorrhoidal bleeding, hematuria, stranguria with blood, metrorrhagia, epistaxis, under the dysentery with red and white feces, the wind heat conjunctival congestion, skin sore, and be used for prevention of stroke.Select for use Rhizoma Paridis to be because its nature and flavor toil is cold, poisonous, go into the heart, Liver Channel, heat-clearing and toxic substances removing is arranged, antiasthmatic-antitussive, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is controlled carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting.Selecting Fructus Aurantii for use is that lung, spleen, large intestine channel are gone in cold, and dispelling the stagnated QI is arranged because of its nature and flavor toil, row expectorant, and the function of removing food stagnancy is controlled chest and diaphragm expectorant and is stagnated, the feeling of stuffiness in chest, the side of body expands, food stagnation, eructation, vomiting weighs proctoptosis, uterine prolapse behind the dysentery.Select for use Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.It is sweet because of its nature and flavor, cold selecting Rhizoma Imperatae for use, goes into lung, stomach, small intestine meridian, and removing heat from blood is arranged, hemostasis, and heat clearing away, the diuretic function is controlled the calentura excessive thirst, spits blood epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select for use Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, go into the heart, spleen, liver, gallbladder meridian, nourishing the liver is arranged, mind calming is calmed the nerves, and the function of arresting sweating is controlled restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Selecting Periostracum Cicadae for use is because its property sweet-salty, and lung, Liver Channel are gone in cold, and diffusing wind heat is arranged, and lung qi dispersing decide the function of convulsion, controls affection due to external wind and heat, the cough hoarseness, and it is smooth that measles is passed through, the rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Selecting Cortex Cinnamomi for use is that heat is gone into kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, the complement sun is arranged, warming the spleen and stomach, removing accumulated cold; The function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass; Chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select for use be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, go into lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, hinder in calentura Tianjin, dry mouth and throat, constipation.Select for use Fructus Mori to be because its nature and flavor are sweet, cold, go into liver, kidney channel has tonifying liver, and kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows the function of liquid, and the treating the liver kidney yin is lost, quenches one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select for use Radix Gentianae to be because its nature and flavor are bitter, cold, go into liver, gallbladder meridian, the eliminating pathogen in the liver excess-fire is arranged, remove the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat , Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the carbuncle skin infection, scrotum swells and ache, the pudendum pruritus due to damp pathogen.Select for use Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, go into liver, kidney channel, invigorating the liver and kidney is arranged, strong waist knee joint function is controlled interior-heat caused by deficiency of YIN, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor; Control menoxenia, amenorrhea stomachache , mass in the abdomen knot gathers, metrorrhagia, and headache due to deficiency of blood, dizzy; Flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select for use Poria cum Radix Pini to be because its property slightly sweet flavor is flat, go into the heart, spleen channel, mind calming is arranged, calm the nerves, the function of diuretic is controlled the palpitation with fear of having a guilty conscience, and is forgetful, insomnia, frightened Epilepsy, dysuria.Select for use Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor is gone into the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the analgesic function is controlled angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia , mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Select for use Zaocys to be because its nature and flavor are sweet, flat, return Liver Channel, dispelling, collateral-activating is arranged, spasmolytic, dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, tic spasm, skin pruritus, leprosy.Select for use Radix Gentianae Macrophyllae to be because its nature and flavor toil is flat, go into liver, stomach, gallbladder meridian, expelling wind and removing dampness and blood Shujin are arranged, the function of clearing away heat and promoting diuresis, the dispelling the wind and dampness pathogens arthralgia pain, the muscles and bones contracture, jaundice is had blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select Semen Sesami Nigrum for use, the different name Semen Lini, its nature and flavor are sweet, and are flat, return liver, kidney, large intestine channel, and invigorating the liver and kidney is arranged, benefiting essence-blood, the function that intestine moistening is dry is controlled and is felt dizzy, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range
Radix Polygoni Multiflori 15-25 gram Flos Sophorae 10-20 gram Rhizoma Paridis 10-20 gram
Fructus Aurantii (parched) 15-25 gram Pericarpium Citri Reticulatae 10-20 gram Rhizoma Imperatae 10-20 gram
Semen Ziziphi Spinosae (parched) 20-30 gram Periostracum Cicadae 8-12 gram Cortex Cinnamomi 10-20 gram
Radix Ophiopogonis, 10-20 gram Fructus Mori 8-12 cron Radix Gentianae 15-25 restrained
Fructus Ligustri Lucidi 10-20 gram Radix Angelicae Sinensis 10-20 gram Poria cum Radix Pini 20-30 gram
Radix Salviae Miltiorrhizae 8-12 gram Radix Rehmanniae Preparata 10-20 gram Zaocys 10-20 gram
Radix Gentianae Macrophyllae 8-12 gram Semen Sesami Nigrum 10-20 gram
Wherein, be preferably
Radix Polygoni Multiflori 20 gram Flos Sophoraes 15 gram Rhizoma Paridis 15 grams
Fructus Aurantii (parched) 15 gram Pericarpium Citri Reticulataes 15 gram Rhizoma Imperataes 15 grams
Semen Ziziphi Spinosae (parched) 25 gram Periostracum Cicadaes 10 gram Cortex Cinnamomis 15 grams
Radix Ophiopogonis, 15 gram Fructus Mori, 10 cron Radix Gentianae 20 restrained
Fructus Ligustri Lucidi 15 gram Radix Angelicae Sinensis 12 gram Poria cum Radix Pinis 25 grams
Radix Salviae Miltiorrhizae 10 gram Radix Rehmanniae Preparata 15 gram Zaocyss 10 grams
Radix Gentianae Macrophyllae 10 gram Semen Sesami Nigrums 15 grams
The method for preparing of medicine of the present invention is following
One, gets the raw materials ready
1, Radix Polygoni Multiflori: choose decontamination, clean, pass through with blister to eighty per cant, pull out, profit to inside and outside humidity is even, and section or dice dry;
2, Flos Sophorae: get crude drug, remove destemming, leaf and impurity, sieve dedust bits;
3, Rhizoma Paridis: get crude drug, remove impurity, soak slightly, clean, run through, cut sheet, drying, sieve removes chip;
4, Fructus Aurantii (parched): get wheat bran and be spread in the heat pot, when the yellow skin of waiting is smoldered, add the Fructus Aurantii sheet, fry to faint yellow, take out, sieve removes wheat bran, cools, and 100 jin of every Fructus Aurantii sheets are with 10 jin in wheat bran;
5, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
6, Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
7, Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in the pot to fry to crust and heave and be little yellow, take out, cool with slow fire;
8, Periostracum Cicadae: choose decontamination, clean and dry;
9, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;
10, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
11, Fructus Mori: wash, choose decontamination, extract long handle, dry;
12, Radix Gentianae: choose decontamination, remove residual stem, clean, run through the back cutting, dry;
13, Fructus Ligustri Lucidi: choose decontamination, clean, dry;
14, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening dries in the air to inside and outside humidity when suitable slightly, and section is dried;
15, Poria cum Radix Pini: get crude drug, remove impurity, section is dried in the shade;
16, Herba Portulacae: choose clean impurity, remove undesirable root, moisten slightly with water, cutting is dried;
17, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry;
18, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;
19, Zaocys: get crude drug, brush away ash bits, the time spent decaptitates, squama, cutting;
20, Radix Gentianae Macrophyllae: choose decontamination, remove removing LU, soak slightly, run through section, dry;
21, Semen Sesami Nigrum: get crude drug, remove impurity, sieve removes chip.
Two, preparation
Radix Polygoni Multiflori, Flos Sophorae, Rhizoma Paridis, Fructus Aurantii (parched), Pericarpium Citri Reticulatae, Rhizoma Imperatae, Semen Ziziphi Spinosae (parched), Periostracum Cicadae, Cortex Cinnamomi, Radix Ophiopogonis, Fructus Mori, Radix Gentianae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, Poria cum Radix Pini, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Zaocys, Radix Gentianae Macrophyllae, the Semen Sesami Nigrum of said weight are added 1500 ml waters immersion 60 minutes; Intense fire decocts boiling 30 minutes; Reuse slow fire boiling to 500 milliliter gets final product, and decoction liquor is equally divided into 3 doses.
Medicine of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and the effect of anti-inflammatory anti-itch is used to treat the skin pruritus instant effect, and short treating period does not recur.
Below come further to set forth the beneficial effect of medicine of the present invention, these tests to comprise that the animal toxicity test of medicine of the present invention and clinical observation test through Test Example.
The animal toxicity test report of [Test Example 1] medicine of the present invention
Get 20 of rabbit, the male and female dual-purpose, body weight 2kg divides two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [Test Example 2] medicine of the present invention
1, physical data
Accept out-patient's 185 examples for medical treatment, wherein light-duty type of 110 examples, heavy type 75 examples.
2, diagnostic criteria
Skin pruritus has the branch of limitation and general property; General the initial skin pruritus of property skin pruritus patient only is confined to a place, is light-duty pruritus card, and then extends to big of health or whole body gradually; Develop into heavy pruritus card; Skin pruritus often for paroxysmal especially attaching most importance to night owing to constantly scratch, secondary lesions such as scratch, blood crusts, pigmentation and lichenificationization appear.The limitation skin pruritus betides a certain position of health, and common have pruritus ani, scrotal pruritus, vulval pruritus, a capital pruritus disease etc.
3, Therapeutic Method
Select above-mentioned medicament for use, take for light-duty type of patient, take 1 dose at every turn, every day early, respectively obey 1 time evening, 10 days is a course of treatment, takes two courses of treatment continuously.Take for a heavy type patient, take 1 dose at every turn, every day is early, middle and late respectively obeys 1 time, and 10 days is a course of treatment, takes three courses of treatment continuously.
4, efficacy assessment standard
Produce effects: treatment back clinical symptom disappearance, it is normal that skin recovers, and observes and do not have the recidivist half a year;
Take a turn for the better: clinical symptoms is obviously improved, and skin progressively recovers;
Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy skin pruritus patient 185 examples of the present invention, wherein light-duty type 110 examples, produce effects 105 examples as a result, obvious effective rate is 95.45%, 4 examples that take a turn for the better, improvement rate is 3.64%, invalid 1 example, total effective rate is 99.09%; Heavy type 75 examples of treatment, produce effects 65 examples, obvious effective rate is 86.67%, 8 examples that take a turn for the better, improvement rate is 10.67%, invalid 2 examples, total effective rate is 97.34%.
Claims (3)
1. medicine of treating skin pruritus, it is characterized in that: it is to be processed by the crude drug in the following weight scope:
Radix Polygoni Multiflori 15-25 gram Flos Sophorae 10-20 gram Rhizoma Paridis 10-20 gram
Fructus Aurantii (parched) 15-25 gram Pericarpium Citri Reticulatae 10-20 gram Rhizoma Imperatae 10-20 gram
Semen Ziziphi Spinosae (parched) 20-30 gram Periostracum Cicadae 8-12 gram Cortex Cinnamomi 10-20 gram
Radix Ophiopogonis, 10-20 gram Fructus Mori 8-12 cron Radix Gentianae 15-25 restrained
Fructus Ligustri Lucidi 10-20 gram Radix Angelicae Sinensis 10-20 gram Poria cum Radix Pini 20-30 gram
Radix Salviae Miltiorrhizae 8-12 gram Radix Rehmanniae Preparata 10-20 gram Zaocys 10-20 gram
Radix Gentianae Macrophyllae 8-12 gram Semen Sesami Nigrum 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Polygoni Multiflori 20 gram Flos Sophoraes 15 gram Rhizoma Paridis 15 grams
Fructus Aurantii (parched) 15 gram Pericarpium Citri Reticulataes 15 gram Rhizoma Imperataes 15 grams
Semen Ziziphi Spinosae (parched) 25 gram Periostracum Cicadaes 10 gram Cortex Cinnamomis 15 grams
Radix Ophiopogonis, 15 gram Fructus Mori, 10 cron Radix Gentianae 20 restrained
Fructus Ligustri Lucidi 15 gram Radix Angelicae Sinensis 12 gram Poria cum Radix Pinis 25 grams
Radix Salviae Miltiorrhizae 10 gram Radix Rehmanniae Preparata 15 gram Zaocyss 10 grams
Radix Gentianae Macrophyllae 10 gram Semen Sesami Nigrums 15 grams.
3. according to the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Radix Polygoni Multiflori: choose decontamination, clean, pass through with blister to eighty per cant, pull out, profit to inside and outside humidity is even, and section or dice dry;
(2) Flos Sophorae: get crude drug, remove destemming, leaf and impurity, sieve dedust bits;
(3) Rhizoma Paridis: get crude drug, remove impurity, soak slightly, clean, run through, cut sheet, drying, sieve removes chip;
(4) Fructus Aurantii (parched): get wheat bran and be spread in the heat pot, when the yellow skin of waiting is smoldered, add the Fructus Aurantii sheet, fry to faint yellow, take out, sieve removes wheat bran, cools, and 100 jin of every Fructus Aurantii sheets are with 10 jin in wheat bran;
(5) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
(6) Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
(7) Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in the pot to fry to crust and heave and be little yellow, take out, cool with slow fire;
(8) Periostracum Cicadae: choose decontamination, clean and dry;
(9) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;
(10) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(11) Fructus Mori: wash, choose decontamination, extract long handle, dry;
(12) Radix Gentianae: choose decontamination, remove residual stem, clean, run through the back cutting, dry;
(13) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(14) Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening dries in the air to inside and outside humidity when suitable slightly, and section is dried;
(15) Poria cum Radix Pini: get crude drug, remove impurity, section is dried in the shade;
(16) Herba Portulacae: choose clean impurity, remove undesirable root, moisten slightly with water, cutting is dried;
(17) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry;
(18) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;
(19) Zaocys: get crude drug, brush away ash bits, the time spent decaptitates, squama, cutting;
(20) Radix Gentianae Macrophyllae: choose decontamination, remove removing LU, soak slightly, run through section, dry;
(21) Semen Sesami Nigrum: get crude drug, remove impurity, sieve removes chip;
(2) preparation
Radix Polygoni Multiflori, Flos Sophorae, Rhizoma Paridis, Fructus Aurantii (parched), Pericarpium Citri Reticulatae, Rhizoma Imperatae, Semen Ziziphi Spinosae (parched), Periostracum Cicadae, Cortex Cinnamomi, Radix Ophiopogonis, Fructus Mori, Radix Gentianae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, Poria cum Radix Pini, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Zaocys, Radix Gentianae Macrophyllae, the Semen Sesami Nigrum of said weight are added 1500 ml waters immersion 60 minutes; Intense fire decocts boiling 30 minutes; Reuse slow fire boiling to 500 milliliter gets final product, and decoction liquor is equally divided into 3 doses.
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