CN102579818B - Traditional Tibetan medicine composition, preparation method thereof and application - Google Patents
Traditional Tibetan medicine composition, preparation method thereof and application Download PDFInfo
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Abstract
The invention discloses a traditional Tibetan medicine composition, takes examples by the experience of traditional Tibetan medicine in prevention and treatment of kidney deficiency diseases, selects traditional Tibetan medicines for reasonable matching, and provides the traditional Tibetan medicine composition with herbal medicines serving as main components. The Tibetan medicine composition adopts agama himalayana, radix pleurospermi tibetanic, rhizoma polygonati, Himalaya mirabilis jalapa, caltrop, radix asparagi, medusa maxim and milk as a basic formula, and under a preferable condition, other Tibetan medicine components including seeds of pomegranates, red flowers, cordyceps sinensis, conic gymnadenia tuber, gastrodia elata and the like can be further added. A preparation method of the Tibetan medicine composition and the application of the method in the preparation of the medicine for treating the kidney deficiency diseases are further provided. The traditional Tibetan medicine composition directly acts on a human body visceral organ, is verified by clinic experiments to be capable of being applied to treatment of deficiency of kidney yin and yang diseases, is remarkable in medicine efficiency, short in curative period and free of toxic and side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of can be for the preparation of the Tibetan medicinal composition for the treatment of kidney deficiency disease drug.
Background technology
The concept of traditional medicine said " kidney " and western medicine said " kidney " have very big-difference.The said kidney of doctor trained in Western medicine is anatomical concepts, refers to a pair of organ in urinary system.Kidney in traditional medicine is a functional concept, the functional activity of a plurality of systems in the general reference human body, and be not a certain certain organs.Kidney in traditional medicine participates in most of biological function of the vital movement, particularly regulating and controlling hormonal system of human body hormonal system, nervous system, urinary system, motor system, respiratory system, digestive system, reproductive system 7 large systems.The whole life process of the vital essence dominant force mankind's of kidney growth, growth, maturation, death, so kidney is called " the congenital foundation " by traditional medicine.
Suffering from a deficiency of the kidney is the peculiar concept of traditional medical theory, and general reference is because of the not enough a plurality of system diseases that cause of kidney essense gas negative and positive in human body.According to the yin or yang excess difference partially declined of essence in kidney, the different performances such as comprising deficiency of kidney-YIN, kidney yang virtual loss, instability of kidney QI, failure of the kidney in receiving QI, kidney yin kidney yang two void, deficiency of the kidney yin hyperactivity of fire of suffering from a deficiency of the kidney.Clinically, generally be divided into briefly two kinds of syndrome of deficiency of kidney yin and syndrome of deficiency of kidney-YANG.The main manifestations of suffering from a deficiency of the kidney is: Hiccough and deaf, loss of hairs withered worried, luxated tooth is sparse, aching pain in waist and back, shank are soft, talalgia, sexual function are not normal, CHI-pulse being weak etc.Deficiency of the kidney yin can have dysphoria with feverish sensation in the chest palms and soles, insomnia, dreaminess, night sweat, dry mouth and throat concurrently, has a dizzy spell on the symptom basis of suffering from a deficiency of the kidney, nocturnal emission, afternoon flushed cheeks, the few tongue of red tongue or the symptoms such as crackle, thready and rapid pulse are arranged.Insufficiency of kidney-YANG can have pale complexion, cold extremities concurrently, creeping chill is arranged below abdomen on the symptom basis of suffering from a deficiency of the kidney, clear urine in large amounts, watery diarrhea with indigested food, Diarrhoea, frequent micturition, emission, impotence and premature ejaculation, drown after the heeltap, leukorrhagia rare clearly, infertility, hydroderma, foot is swollen, lower limb is swollen, light red tongue is fat, white and moist fur, faint and weak pulse and the symptom such as slow.
In the Tibetanmedicine rationale, the three large factors that exist in human body, seven kinds of materials and three kinds of material bases that the common formation of Excreta sustains life.In three large factors " grand ", " red bar ", " Baconic ", grand is gas, is gathered in brains, cardiopulmonary and skeleton, and supervisor breathes, circulates, feels, moves; Red bar is fire, is dispersed in liver and blood the generation of facilitating digestion, absorption and heat energy and wisdom; Baconic is water and soil, is present in spleen, stomach, intravesical, can regulate digestion and water balance, affects people's body weight and disposition.In human body, kidney has " water ", " soil " character, has the body fluid of generation and metabolic important function.Due to grand in body, red bar, Baconic's three categories of etiologic factors procatarxis are inside and outside, and certain is former thereby occur can causing renal function unbalance when too prosperous or on the decline, and body disease occurs.Particularly human body is for a long time in wet environment or reason such as contact cold water etc., and has a liking for sweet or have a liking for raw and cold dietary habit etc., all can make the vital essence negative and positive deficiency of kidney in human body, causes the pathological changes of multiple human body physiological system, and causes the disease of suffering from a deficiency of the kidney.Tradition Tibetan medicine theory is divided into 8 large types by kidney disease, wherein the suffer from a deficiency of the kidney disease of the renal function imbalance that is mainly cold pathological changes, the different manifestations such as the described deficiency of kidney-YIN of similar Chinese medicine, kidney yang virtual loss, instability of kidney QI, failure of the kidney in receiving QI, kidney yin kidney yang two void, deficiency of the kidney yin hyperactivity of fire.The Tibetan medicine clinically, generally also will suffer from a deficiency of the kidney and briefly be divided into triumphant plan card (insufficiency of kidney-YANG) and two kinds of triumphant normal cards (deficiency of the kidney yin).
Healthwise evaluation with western medicine, the alleged disease of suffering from a deficiency of the kidney of traditional medicine not specially refers to kidney organ's pathological changes, and it belongs to the sub-health state of the multiple functional system function of the body comprehensive pathological changes of the uncomfortable body caused or the decline of animal economy function level in essence.
Tibetanmedicine in traditional medicine results from China's Qinghai-xizang Plateau Region, long-term specific aim is alleviated with control because the physical function burden that the plateau severe environmental conditions such as height above sea level, air drying are thin cause to the local resident occurs with disease, aspect the functional activity adjusting for the human body multisystem, is accumulating a large amount of experiences.
Summary of the invention
Purpose of the present invention is exactly for the deficiencies in the prior art, provide a kind of can be for the preparation of the Tibetan medicinal composition for the treatment of kidney deficiency disease drug.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of Tibetan medicinal composition is characterized in that: contain 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts, milk.
In above-mentioned Tibetan medicinal composition:
Agama himalayana, be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard number WS3-BC-0102-95, Tibetan medicine title: hide bar), is that the drying of Iguanidae animal Agama himalayana (Agama himalayana) is all.Main effect is Yang nourishing-strengthening.For the renal cold disease, sexual impotence, the diseases such as seminal emission.
Herba pleurospermi thomsonii (Tibetan medicine title: add) is the dry herb of dicotyledon medicine Umbelliferae rib apium plant Herba pleurospermi thomsonii (Pleurospermum Hoffm).Main effect is regulating QI to relieve pain, blood circulation promoting and blood stasis dispelling.
Rhizoma Polygonati (Tibetan medicine title: La Ni), be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll.et Hemsl.), Rhizoma Polygonati (P.sibiricum Red.) or Polygonatum cyrtonema Hua (P.cyrtonema Hua).Return spleen, lung, kidney channel.Main effect is spleen reinforcing, the lung moistening and production of body fluid promoting, for weakness of the spleen and stomach, deficiency of the lung cough caused by dryness, interior-heat, quenches one's thirst.
Radix Mirabilis himalaicae, be recorded in " Tibetan medicine is promulgated by the ministries or commissions of the Central Government " (standard No.: WS3-BC-0103-95, Tibetan language title: the bar Zhu), be Nyctaginaceae plant Radix Mirabilis himalaicae (Mirabilis himalaica(Edgew.) Heim.) dry root.Function is the kidney warming, granulation promoting, diuresis, calculus, yellow fluid reducing with curing mainly.For cold syndrome of the stomach, renal cold, lower coldness of the body, sexual impotence edema, vesical calculus, lumbago, arthralgia, yellow fluid pain.
Fructus Tribuli (Tibetan medicine title: Sai Ma), be the dry mature fruit of zygophyllaceae plant Fructus Tribuli (Tribulus terrestris L.).Return Liver Channel.Main effect is the suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, and improving eyesight, antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus.
Radix Asparagi is the tuber of Liliaceae asparagus plant Radix Asparagi (Asparagus cochinchinensis).Main effect is to control the consumptive lung disease lung abscess, and vomiting pus is spitted blood, phlegmatic cough dyspnea with rapid and short breath, the choke universe of quenching one's thirst.The foot burning pain, the asthenia hectic fever due to YIN-deficiency, the deficiency of YIN has the card of fire.
Saussurea medusa Maxim. (the Tibetan medicine title: just fruit Soviet Union clings to) is the herb of Compositae phoenix hair Dendranthema Saussurea medusa Maxim. (Saussurea medusa Maxim.).Main effect is to cure mainly anthrax, contracture of the limbs, and aortic arch syndrome, He Ruhu, rheumatic arthropathy, the old skin infection, the sword wound is hemorrhage, cerebral concussion, amenorrhea, placenta retention.
Milk is the medicinal herbs most in use in Tibetan medicine.According to " Jingzhubencao ", put down in writing, the flavor of milk and change flavor are all sweet, the property profit, the flourish color of effect, training unit, the benefit essence, nutrition, long fat, naughty skin, ortho sleep are provided, and property is heavy and cool, can neutralize and be dispersed in heat energy in liver and blood, there is regulate body temperature, keep complexion, give birth to wisdom, digestant effect.Wherein with cattle milk, nourish most, sharp lung disease, lung obstinate disease, treatment blood, red bar complication, with the passing of time, frequent micturition disease, gas have some setbacks pestilence, expectorant is unfavorable, tiredly cut down unable, giddy and revolve, and can support Rong Zengli.
It is basis to the pathological study of the disease of suffering from a deficiency of the kidney that above-mentioned Tibetan medicinal composition be take traditional Tibetanmedicine, for aching pain in waist and back, shank is soft, sexual function is not normal, insomnia, dreaminess, night sweat, dry mouth and throat, have a dizzy spell, frequent micturition, emission, impotence and premature ejaculation, infertility, hydroderma, foot is swollen, lower limb is swollen, light red tongue is fat, white and moist fur, faint and weak pulse and men and women's property such as slow are suffered from a deficiency of the kidney disease the temperature compensation of suiting the medicine to the illness and this Therapeutic Principle being made support essence, the combined pharmaceutical formulation of QI and blood dredging.Analysis is by the cause of disease, the focus of the various disease conditions due to the kidney essense QI-insufficiency, choose several flavors such as Rhizoma Polygonati, Herba pleurospermi thomsonii, Fructus Tribuli, Radix Mirabilis himalaicae, Radix Asparagi and be widely used in traditional Tibetan medicine material of suffering from a deficiency of the kidney and treating, selected Agama himalayana, Saussurea medusa Maxim., milk 3 flavor Tibetan medicine materials simultaneously.Wherein, though Agama himalayana records the effect of " for the renal cold disease " in Tibetan medicine standard promulgated by the ministries or commissions of the Central Government, be not disclosed at present any treatment and suffer from a deficiency of the kidney in the Tibetan medicinal composition component of disease.This Tibetan medicinal composition, according to the medical knowledge of traditional medicine " warming and recuperating the kidney-YANG nourishes kidney yin ", by the rational proportion to selected medical material, carries out many-sided body function to the disease of suffering from a deficiency of the kidney and regulates, and reaches therapeutic purposes.
The above-mentioned 8 flavor medicines of take are basic recipe, and this Tibetan medicinal composition formula can also be expanded optimization, to strengthen drug effect.Specifically also contain 30～50 parts of Semen Granati, 28～50 parts, Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts, Rhizoma Gastrodiae.
Semen Granati, be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard number WS3-BC-0026-95, Tibetan medicine title: match Zhu), be Punicaceae plant pomegranate (Punica granatum L.) dry seed.Cure mainly Baconic's sympotoms caused by cold factors, cold syndrome of the stomach disease and all gastropathy.
Flos Carthami, the another name Flos Carthami, be the tubular flower of dicotyledon medicine feverfew Flos Carthami (Carthamus tinctorius L.).Main effect be to invigorate blood circulation latus rectum, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.
Cordyceps, have another name called Cordyceps, Cordyceps, Cordyceps sinensis.That section ergot fungus cordyceps sinensis bacterium (Cordyceps sinensis) colonizes in Stroma and the larva cadaveric complex on Hepialidae insecticide Hepialus armorieanus Oberthur (Hepialus armoricanus Oberthur) Overwintering Larvae.Return lung, kidney channel.Main effect is invigorating the lung and the kidney, hemostasis and phlegm.For the chronic cough dyspnea due to deficiency, the chronic cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint, be the famousst and precious strengthening by means of tonics medicine had won fame both at home and abroad.
Rhizoma Gymnadeniae, be recorded in " Tibetan medicine is promulgated by the ministries or commissions of the Central Government " (standard No.: WS3-BC-0015-95, Tibetan language title: prosperous drawing), have another name called Rhizoma Gymnadeniae, be the dry tuber of orchid Rhizoma Gymnadeniae (Gymnadenia conopsea R.Br.), there is the effect of benefiting vital QI and blood, promoting the production of body fluid to quench thirst, to cough and asthma due to lung deficiency, asthenia become thin, the aspect such as neurasthenia has very high health preserving and is worth, mainly edible as tonic on Tibet and other places, be commonly used for and steep in wine, praise soup or boil.
Rhizoma Gastrodiae is the dry tuber of orchid Rhizoma Gastrodiae (Gastrodia elata Bl.).Rhizoma Gastrodiae embellishes but not dry, and the master enters Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, and the disease of all liver-wind stirring up internallys, the vertigo, no matter deficiency and excess is all important medications.
The present invention also provides the application of above-mentioned Tibetan medicinal composition in preparation treatment kidney deficiency disease drug.
Tibetan medicinal composition provided by the invention is verified the disease of suffering from a deficiency of the kidney that can be applied to prevent and treat multiple crowd through clinical trial, comprise insufficiency of kidney-YANG (triumphant plan disease) or the deficiency of the kidney yin (triumphant normal disease) of clinical diagnosis.Particularly take have a delicate constitution, tired, the chronic problem of spirit, urine are not normal, alopecia, forgetful, sweating due to debility, insomnia, sexual hypofunction, urine urgency-frequency, premature ejaculation etc. are sign multiple crowd's kidney deficiency disease.
The present invention also provides the preparation method of above-mentioned Tibetan medicinal composition simultaneously, and concrete scheme is as follows:
The preparation method of above-mentioned Tibetan medicinal composition is characterized in that: each medical material component is configured in proportion, according to traditional patent medicine processing method, add in case of necessity acceptable adjuvant on pharmaceutics to be prepared into different dosage form.
Concrete dosage form can be the multiple dosage form of oral administration, as capsule, powder, granule, pill, tablet, decoction, unguentum, medicated wine, syrup, butter fat medicine, You concentrating agents etc.
Compared with prior art, the invention has the beneficial effects as follows: (1) this Tibetan medicinal composition adopts tradition medical material common, commonly used in Tibetan medicine and pharmacology to be prepared from according to traditional Tibetan medicine concocting method, is that the former medicine of medical material or preparation method are all safe and reliable; (2) Tibetan medicinal composition be applied to prevent and treat multiple crowd suffer from a deficiency of the kidney the disease drug effect significantly, short treating period, have no side effect.
The accompanying drawing explanation
Fig. 1 is basic components capsule, powder preparation flow figure.
Fig. 2 is expansion optimization of C/C composites capsule, powder preparation flow figure.
Fig. 3 is basic components granule preparation flow figure.
Fig. 4 is expansion optimization of C/C composites granule preparation flow figure.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are further described.
Embodiment mono-
As shown in Figure 1, the preparation of Tibetan medicinal composition capsule formulation.
Tibetan medicinal composition component and weight proportion thereof are: 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts, milk.
The following technique preparation of concrete employing:
Step S1, get Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials and adopt the decocting cooking methods to extract, obtain extracting solution;
During decoction, amount of water is 11～13 times of medical material volume, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; Getting twice decoction extracting solution mixes standby.
Step S2, get step S1 gained extracting solution and add while hot milk to mix to boil altogether 20～40min, boil altogether liquid and be concentrated into 0.8～1.0 ° of B é of Baume degrees, more spray-dried extract powder;
Milk is preferably fresh not skim milk.88 ℃～105 ℃, extracting solution and milk boil altogether.
Step S3, get Agama himalayana and be processed as fine powder, mix with step 2 gained extract powder, obtain mixed powder.
The optimum condition of extract powder and Agama himalayana powder married operation for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilizing, capsule charge 0.4g/ grain.
Disinfecting action is selected the ozone fumigation, and operating condition is density 1.68, circulation 2hr, entirely arranges 18 ℃～26 ℃ of 2hr, temperature, humidity 45%～65%.
Embodiment bis-
As shown in Figure 2, the preparation of Tibetan medicinal composition capsule formulation.
Tibetan medicinal composition component and weight proportion thereof are: 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts, milk, 30～50 parts of Semen Granati, 28～50 parts, Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts, Rhizoma Gastrodiae.
Step S1～step S2 is with embodiment mono-.
Step S3, to get Agama himalayana, Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 6 flavor processing of crude drugs be fine powder, with step 2 gained extract powder, mixes, and obtains mixed powder.
The optimum condition of extract powder and medical material fine powder married operation for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilizing, capsule charge 0.4g/ grain.
Embodiment tri-
As shown in Figure 2, the preparation of Tibetan medicinal composition powder.
Tibetan medicinal composition component and weight proportion thereof are with embodiment bis-.
Step S1～step S3 is with embodiment bis-.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilizing, packing.
Embodiment tetra-
As shown in Figure 3, the preparation of Tibetan medicinal composition granule dosage form.
Tibetan medicinal composition component and weight proportion thereof are same embodiment mono-.
Step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim. 6 flavor Tibetan medicine materials according to formula proportion and adopt the method that decocts with water to extract, obtain extracting solution.
During decoction, amount of water is 11～13 times of medical material volume, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; Getting twice decoction extracting solution mixes standby.
Step S2, get step S1 gained extracting solution and add while hot milk to mix to boil altogether 20～40min, boil altogether liquid and be concentrated into 0.8～1.0 ° of B é of Baume degrees, more spray-dried extract powder.
Milk is preferably fresh not skim milk.88 ℃～105 ℃, extracting solution and milk boil altogether.
Step S3, get Agama himalayana and be processed as fine powder, mix with step 2 gained extract powder, obtain mixed powder.
The optimum condition of extract powder and Agama himalayana powder married operation for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step S3 gained mixed powder and cross 80 mesh sieves, according to medicated powder: water (W/W)=2:1 ratio adds water, granulate, and drying, granulate, cross 24 mesh sieves, and sterilizing, obtain granule, packing.
Water take in this step as excipient.It is 2% that dry moisture is controlled according to conventional index.
Embodiment five
As shown in Figure 4, the preparation of Tibetan medicinal composition granule dosage form.
Tibetan medicinal composition component and weight proportion thereof are same embodiment bis-.
Step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim., Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 12 flavor Tibetan medicine materials according to formula proportion and adopt the method that decocts with water to extract, obtain extracting solution.
During decoction, amount of water is 11～13 times of medical material volume, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; Getting twice decoction extracting solution mixes standby.
Step S2～step S4 is with embodiment tetra-.
Embodiment six
The process of preparing Chinese medicine of Agama himalayana.
In the preparation method of the Tibetan medicinal composition of putting down in writing in the various embodiments described above, the concocting method of Agama himalayana can be improved, to strengthen its drug effect.Concrete grammar is: first Agama himalayana is put to death, remove internal organs, head, afterbody, clear water is cleaned, and steeps into traditional highland barley wine; Add Moschus in barley wine, stir while adding, addition is for starting to smell the Moschus flavor, and container is added a cover and soaked 8～10hr; Heating barley wine to 60 ℃～70 ℃, be cooled to 25 ℃～35 ℃, takes out Agama himalayana, and cold water is cleaned, and dries in the shade standby.
This Tibetan medicinal composition can be made multiple peroral dosage form according to traditional Tibetan medicine processing method, is not limited to the technical scheme of above each embodiment record.
Test example one
Embodiment mono-, four makes Tibetan medicinal composition and makes the application of agent in disease is suffered from a deficiency of the kidney in treatment with prevention.Sufferer diagnosis and treatment record is in Table 1.
Table 1 sufferer diagnosis and treatment records (13 example)
Test example two
Embodiment bis-, three, five makes Tibetan medicinal composition and makes the application of agent in disease is suffered from a deficiency of the kidney in treatment with prevention.
Sufferer diagnosis and treatment record is in Table 2.Curative effect determinate standard is divided into reference to " new Chinese medicine guideline of clinical investigations ": clinical recovery: the symptom of suffering from a deficiency of the kidney, sign disappear, produce effects: the symptom of suffering from a deficiency of the kidney, sign are obviously improved, effectively: the symptom of suffering from a deficiency of the kidney, sign all take a favorable turn, invalid: the symptom of suffering from a deficiency of the kidney, sign are unchanged.Sufferer diagnosis and treatment curative effect statistics is in Table 3.
Table 2 sufferer diagnosis and treatment records (26 example)
Continuous upper table
Table 3 sufferer diagnosis and treatment curative effect statistics (100 example)
| ? | Clinical recovery | Produce effects | Effectively | Invalid | Amount to |
| Sufferer number (example) | 10 | 30 | 50 | 10 | 100 |
| Curative effect ratio (%) | 10 | 30 | 50 | 10 | 100 |
Test example one, two data show Tibetan medicinal composition basic recipe of the present invention all can effectively be applied to prevent and treat the preparation of kidney deficiency disease drug with the expansion optimization of C/C composites.
Test example three
The test of mixed powder measurement of water-content coefficient.
Each dosage form prepares the gained mixed powder and carries out the measurement of water-content coefficient test, and every kind of dosage form repeats 2 tests, and data record sees attached list 4.Each formulation completes the front moisture content of packing capsule<9.0%, powder moisture content<9.0%, granule moisture content<6.0%, all meets the state-promulgated pharmacopoeia standard.
Subordinate list 4 mixed powder moisture content
Annotate: W1-empty weighing botle weight; W2-empty weighing botle weight and medicated powder weight; Empty weighing botle and medicated powder weight after W3-drying.
Claims (15)
1. a Tibetan medicinal composition for the treatment of kidney deficiency, it is characterized in that: crude drug is 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts, milk.
2. the preparation method of Tibetan medicinal composition according to claim 1, is characterized in that: each medical material component is configured in proportion, according to traditional patent medicine processing method, add in case of necessity acceptable adjuvant on pharmaceutics to be prepared into different dosage form.
3. preparation method according to claim 2, it is characterized in that: described Agama himalayana concocting method is: Agama himalayana is put to death, and removes internal organs, head, afterbody, clean, steep into traditional highland barley wine, in barley wine, add Moschus, stir while adding, addition is for starting to smell the Moschus flavor, brewed 8～10hr, heating barley wine to 60 ℃～70 ℃, be cooled to 25 ℃～35 ℃, take out Agama himalayana, cold water is cleaned, and dries in the shade standby.
4. according to the described preparation method of claim 2 or 3, it is characterized in that: described dosage form comprises capsule, powder, granule, pill, tablet, decoction, unguentum, medicated wine, syrup, butter fat medicine, You concentrating agents.
5. preparation method according to claim 4 is characterized in that: according to adding as follows the preparation of one of technique:
Technique one: step S1, get Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials employing decocting cooking methods extractions according to formula proportion, obtains extracting solution; Step S2, get step S1 gained extracting solution and add milk to mix altogether to boil, and boils altogether that liquid is concentrated, spray drying obtains extract powder; Step S3, get Agama himalayana and be processed as fine powder, with step 2 gained extract powder, mixes, and obtains mixed powder; Step S4, step 3 gained mixed powder sieves, and sterilizing, make powder or filling becomes capsule;
Technique two: step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim. 6 flavor Tibetan medicine materials according to formula proportion and adopt the method that decocts with water to extract, obtain extracting solution; Step S2, get step S1 gained extracting solution and add milk to mix altogether to boil, and boils altogether that liquid is concentrated, spray drying obtains extract powder; Step S3, get Agama himalayana and be processed as fine powder, with step 2 gained extract powder, mixes, and obtains mixed powder; Step S4, step S3 gained mixed powder sieves, and adding water is excipient, granulate, drying, granulate, sieve, and sterilizing obtains granule.
6. preparation method according to claim 4, it is characterized in that: in described step S2, extracting solution adds fresh not skim milk to mix, and 88 ℃～105 ℃ are boiled 20～40min altogether, boil altogether liquid and be concentrated into 0.8～1.0 ° of B é of Baume degrees, the more spray-dried extract powder that obtains; Described step S3 extract powder is to mix 30～40min in the 85rpm grinder-mixer with medicated powder married operation condition; Described disinfecting action is the ozone fumigation, and operating condition is density 1.68, circulation 2hr, entirely arranges 18 ℃～26 ℃ of 2hr, temperature, humidity 45%～65%; Described technique two, in step S4, the excipient addition is medicated powder: water (W/W)=2:1.
7. a Tibetan medicinal composition for the treatment of kidney deficiency, it is characterized in that: crude drug is 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts, milk, 30～50 parts of Semen Granati, 28～50 parts, Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts, Rhizoma Gastrodiae.
8. the preparation method of Tibetan medicinal composition according to claim 7, is characterized in that: each medical material component is configured in proportion, according to traditional patent medicine processing method, add in case of necessity acceptable adjuvant on pharmaceutics to be prepared into different dosage form.
9. preparation method according to claim 8, it is characterized in that: described Agama himalayana concocting method is: Agama himalayana is put to death, and removes internal organs, head, afterbody, clean, steep into traditional highland barley wine, in barley wine, add Moschus, stir while adding, addition is for starting to smell the Moschus flavor, brewed 8～10hr, heating barley wine to 60 ℃～70 ℃, be cooled to 25 ℃～35 ℃, take out Agama himalayana, cold water is cleaned, and dries in the shade standby.
10. preparation method according to claim 8 or claim 9, it is characterized in that: described dosage form comprises capsule, powder, granule, pill, tablet, decoction, unguentum, medicated wine, syrup, butter fat medicine, You concentrating agents.
11. preparation method according to claim 10 is characterized in that: according to adding as follows the preparation of one of technique:
Technique one: step S1, get Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials employing decocting cooking methods extractions according to formula proportion, obtains extracting solution; Step S2, get step S1 gained extracting solution and add milk to mix altogether to boil, and boils altogether that liquid is concentrated, spray drying obtains extract powder; Step S3, getting Agama himalayana, Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 6 flavor processing of crude drugs is fine powder, with step 2 gained extract powder, mixes to obtain mixed powder; Step S4, step 3 gained mixed powder sieves, and sterilizing, make powder or filling becomes capsule;
Technique two: step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim., Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 12 flavor Tibetan medicine materials according to formula proportion and adopt the method that decocts with water to extract, obtain extracting solution; Step S2, get step S1 gained extracting solution and add milk to mix altogether to boil, and boils altogether that liquid is concentrated, spray drying obtains extract powder; Step S3, get Agama himalayana and be processed as fine powder, with step 2 gained extract powder, mixes, and obtains mixed powder; Step S4, step S3 gained mixed powder sieves, and adding water is excipient, granulate, drying, granulate, sieve, and sterilizing obtains granule.
12. method according to claim 11, it is characterized in that: in described step S2, extracting solution adds fresh not skim milk to mix, and 88 ℃～105 ℃ are boiled 20～40min altogether, boil altogether liquid and be concentrated into 0.8～1.0 ° of B é of Baume degrees, the more spray-dried extract powder that obtains; Described step S3 extract powder is to mix 30～40min in the 85rpm grinder-mixer with medicated powder married operation condition; Described disinfecting action is the ozone fumigation, and operating condition is density 1.68, circulation 2hr, entirely arranges 18 ℃～26 ℃ of 2hr, temperature, humidity 45%～65%; Described technique two, in step S4, the excipient addition is medicated powder: water (W/W)=2:1.
13. the application according to the described Tibetan medicinal composition of claim 1 or 7 in preparation treatment kidney deficiency disease drug.
14. application according to claim 13 is characterized in that: the deficiency of the kidney yin that the described disease of suffering from a deficiency of the kidney is clinical diagnosis or insufficiency of kidney-YANG disease.
15. application according to claim 14 is characterized in that: the described disease of suffering from a deficiency of the kidney be have a delicate constitution, the multiple crowd's kidney deficiency diseases for characterizing such as tired, the chronic problem of spirit, urine are not normal, alopecia, forgetful, sweating due to debility, insomnia, sexual hypofunction, urine urgency-frequency, premature ejaculation.
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| CN102366540A (en) * | 2011-09-28 | 2012-03-07 | 久美彭措 | Medicine for treating diabetes and its preparation method |
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| CN1919225A (en) * | 2006-09-18 | 2007-02-28 | 中国人民解放军军事医学科学院生物工程研究所 | Application of cultured saussurea medusa and extract thereof in preparation of medicine for treating II type diabetes and its complications |
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Effective date of registration: 20151104 Address after: Lin Qionggang road Lhasa 851400 Tibet autonomous region economic and Technological Development Zone No. 15 Patentee after: TIBET GANLU TIBETAN MEDICINE CO., LTD. Address before: 850000, 23 hot road, Lhasa, Tibet Patentee before: Ci Wang |