CN103356803B - Medicament for treating urticaria, and preparation method thereof - Google Patents

Medicament for treating urticaria, and preparation method thereof Download PDF

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CN103356803B
CN103356803B CN201310317488.6A CN201310317488A CN103356803B CN 103356803 B CN103356803 B CN 103356803B CN 201310317488 A CN201310317488 A CN 201310317488A CN 103356803 B CN103356803 B CN 103356803B
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radix
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张佳奇
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张佳奇
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Abstract

The invention discloses a medicament for treating urticaria, and a preparation method thereof. The medicament is prepared mainly by saposhnikovia divaricata, tree peony bark, bighead atractylodes rhizome, raw rehmannia root, arctium fruit, poria cocos, mint and honeysuckle flower according to a certain weight ratio. The medicament has the functions of clearing heat, detoxifying, activating blood circulation, cooling blood, sterilizing and relieving itching; and the medicament is fast in effectiveness, good in curative effect and high in cure rate when used to treat urticaria.

Description

A kind of medicine for the treatment of urticaria and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of urticaria and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Urticaria is a kind of common dermatosis.It is the mucocutaneous vascular reactivity disease of one caused by multiple different reason.Show as flickering, well-defined, red or white pruritic welt, the traditional Chinese medical science claims " urticaria ", is commonly called as " rubella wheal ".Urticaria drastically influence daily life and the work of patient, and at present, because Western medicine cannot rapid, effective treatment urticaria, therefore, the Chinese medicine of people to rapid, effective treatment urticaria exists great demand.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment urticaria, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating urticaria.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Saposhnikoviae, Cortex Moutan, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Fructus Arctii, Poria, Herba Menthae, Flos Lonicerae, Fructus Aurantii, Bombyx Batryticatus, Fructus Jujubae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Radix Saposhnikoviae, Radix Glycyrrhizae, Folium Mori, Fructus Forsythiae medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating urticaria.Wherein select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle , Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Select Fructus Arctii to be that cool, enter lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the function of subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain because its nature and flavor are worked hard, macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Bombyx Batryticatus is selected to be because its nature and flavor are pungent, salty, flat, return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea , mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Saposhnikoviae 10-20 grams of Cortex Moutans 10-20 grams of Rhizoma Atractylodis Macrocephalaes 8-15 grams
10-20 grams, Radix Rehmanniae 8-15 grams of Fructus Arctiis 10-20 grams of Poria
Herba Menthae 10-20 grams of Flos Loniceraes 8-15 grams of Fructus Aurantiis 10-20 grams
Bombyx Batryticatus 8-15 grams of Fructus Jujubaes 15-25 grams of Rhizoma Chuanxiongs 8-15 grams
Radix Angelicae Sinensis 10-20 grams of Flos Carthamis 8-15 grams of Radix Saposhnikoviaes 8-15 grams
Radix Glycyrrhizae 13-19 grams of Folium Mori 8-15 grams of Fructus Forsythiaes 8-15 grams
Preferable amount is
Radix Saposhnikoviae 15 grams of Cortex Moutans 15 grams of Rhizoma Atractylodis Macrocephalaes 10 grams
15 grams, Radix Rehmanniae 10 grams of Fructus Arctiis 15 grams of Poria
Herba Menthae 15 grams of Flos Loniceraes 10 grams of Fructus Aurantiis 15 grams
Bombyx Batryticatus 10 grams of Fructus Jujubaes 20 grams of Rhizoma Chuanxiongs 10 grams
Radix Angelicae Sinensis 15 grams of Flos Carthamis 10 grams of Radix Saposhnikoviaes 10 grams
Radix Glycyrrhizae 16 grams of Folium Mori 10 grams of Fructus Forsythiaes 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
2, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
3, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
4, Radix Rehmanniae: removing impurity, cleans, slightly moistens, cut sheet, and dry, sieve removes chip;
5, Fructus Arctii: pick decontamination, sieve removes spare;
6, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
7, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;
8, Flos Lonicerae: sieve removes silt, picks clean impurity;
9, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
10, Bombyx Batryticatus: get crude drug, removes residual silk, impurity;
11, Fructus Jujubae: pick clean impurity, dry;
12, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
13, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
14, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
15, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
16, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
17, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
18, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk.
Two, prepare
1, the Radix Saposhnikoviae of described weight, Cortex Moutan, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Fructus Arctii, Poria, Herba Menthae, Flos Lonicerae, Fructus Aurantii, Bombyx Batryticatus, Fructus Jujubae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Radix Saposhnikoviae, Radix Glycyrrhizae, Folium Mori, Fructus Forsythiae medicine are added 6 times of water gagings and soak, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, twice decoction liquor is merged, then within 10 minutes, obtain medicinal liquid with slow fire boiling, be divided into by medicinal liquid 3 doses to take.
Medicine of the present invention has heat clearing away, removing toxic substances, removing heat from blood, and blood, and sterilization is antipruritic, effect of blood circulation promoting and blood stasis dispelling, and treatment urticaria instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 180 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
One, erythra is paroxysmal skin mucosa flushing or welt, and welt shape differs, differs in size, and color is pale or scarlet, and time disappears when rising, and single welt often continues to be no more than 24 ~ 36 hours, leaves no trace after disappearing.
Two, conscious acute pruritus, minority occurs together heat, arthralgia, headache, Nausea and vomiting, stomachache, diarrhoea, uncomfortable in chest, the General Symptoms such as suffocated breathing, dyspnea, cardiopalmus.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: urticaria is eliminated, without recurring after observing half a year;
Take a turn for the better: urticaria symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy urticaria patient 180 example of the present invention, effective 170 examples of result, obvious effective rate is 94.45%, and take a turn for the better 8 examples, and improvement rate is 4.44%, and invalid 2 examples, total effective rate is 98.89%.

Claims (3)

1. treat a medicine for urticaria, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Saposhnikoviae 10-20 grams of Cortex Moutans 10-20 grams of Rhizoma Atractylodis Macrocephalaes 8-15 grams
10-20 grams, Radix Rehmanniae 8-15 grams of Fructus Arctiis 10-20 grams of Poria
Herba Menthae 10-20 grams of Flos Loniceraes 8-15 grams of Fructus Aurantiis 10-20 grams
Bombyx Batryticatus 8-15 grams of Fructus Jujubaes 15-25 grams of Rhizoma Chuanxiongs 8-15 grams
Radix Angelicae Sinensis 10-20 grams of Flos Carthamis 8-15 grams of Radix Saposhnikoviaes 8-15 grams
Radix Glycyrrhizae 13-19 grams of Folium Mori 8-15 grams of Fructus Forsythiaes 8-15 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Saposhnikoviae 15 grams of Cortex Moutans 15 grams of Rhizoma Atractylodis Macrocephalaes 10 grams
15 grams, Radix Rehmanniae 10 grams of Fructus Arctiis 15 grams of Poria
Herba Menthae 15 grams of Flos Loniceraes 10 grams of Fructus Aurantiis 15 grams
Bombyx Batryticatus 10 grams of Fructus Jujubaes 20 grams of Rhizoma Chuanxiongs 10 grams
Radix Angelicae Sinensis 15 grams of Flos Carthamis 10 grams of Radix Saposhnikoviaes 10 grams
Radix Glycyrrhizae 16 grams of Folium Mori 10 grams of Fructus Forsythiaes 10 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(2) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
(3) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(4) Radix Rehmanniae: removing impurity, cleans, slightly moistens, cut sheet, and dry, sieve removes chip;
(5) Fructus Arctii: pick decontamination, sieve removes spare;
(6) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(7) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;
(8) Flos Lonicerae: sieve removes silt, picks clean impurity;
(9) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
(10) Bombyx Batryticatus: get crude drug, removes residual silk, impurity;
(11) Fructus Jujubae: pick clean impurity, dry;
(12) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(13) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(14) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(15) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(16) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(17) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
(18) Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;
(2) prepare
(1) Radix Saposhnikoviae of described weight, Cortex Moutan, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Fructus Arctii, Poria, Herba Menthae, Flos Lonicerae, Fructus Aurantii, Bombyx Batryticatus, Fructus Jujubae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Radix Saposhnikoviae, Radix Glycyrrhizae, Folium Mori, Fructus Forsythiae medicine are added 6 times of water gagings and soak, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;
(2) add water the medicinal residues of filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) twice decoction liquor is merged, then within 10 minutes, obtain medicinal liquid with slow fire boiling, be divided into by medicinal liquid 3 doses to take.
CN201310317488.6A 2013-07-26 2013-07-26 Medicament for treating urticaria, and preparation method thereof Expired - Fee Related CN103356803B (en)

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CN104547908B (en) * 2014-12-26 2018-01-05 江苏苏南药业实业有限公司 A kind of Chinese medicine composition for treating nettle rash and preparation method thereof

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CN101167867A (en) * 2007-09-24 2008-04-30 徐大洋 Traditional Chinese medicine for treating urticaria and cooling blood and reducing damp
CN101757307A (en) * 2008-11-20 2010-06-30 周继红 Traditional Chinese medicine preparation for treating acute urticaria
CN101757239A (en) * 2008-11-17 2010-06-30 贾国民 Traditional Chinese medicine formula for treating urticaria
CN101985009A (en) * 2010-07-02 2011-03-16 荣成市科学技术情报研究所 Chinese medicinal composition for treating chronic urticaria
CN102225118A (en) * 2011-06-08 2011-10-26 马增旺 Blood-activating wind-dispelling liquid
CN102488873A (en) * 2011-12-02 2012-06-13 韩玉红 Chinese medicinal preparation for treating urticaria
CN103083457A (en) * 2012-12-11 2013-05-08 宋协勘 Traditional Chinese medicine for treating chronic urticaria

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1528416A (en) * 2003-10-17 2004-09-15 陕西康惠制药有限公司 Granuless for treating psoriasis and preparing process thereof
CN101167867A (en) * 2007-09-24 2008-04-30 徐大洋 Traditional Chinese medicine for treating urticaria and cooling blood and reducing damp
CN101757239A (en) * 2008-11-17 2010-06-30 贾国民 Traditional Chinese medicine formula for treating urticaria
CN101757307A (en) * 2008-11-20 2010-06-30 周继红 Traditional Chinese medicine preparation for treating acute urticaria
CN101985009A (en) * 2010-07-02 2011-03-16 荣成市科学技术情报研究所 Chinese medicinal composition for treating chronic urticaria
CN102225118A (en) * 2011-06-08 2011-10-26 马增旺 Blood-activating wind-dispelling liquid
CN102488873A (en) * 2011-12-02 2012-06-13 韩玉红 Chinese medicinal preparation for treating urticaria
CN103083457A (en) * 2012-12-11 2013-05-08 宋协勘 Traditional Chinese medicine for treating chronic urticaria

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