CN103330780B - Medicine for curing varicose vein of lower limb and preparation method thereof - Google Patents
Medicine for curing varicose vein of lower limb and preparation method thereof Download PDFInfo
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- CN103330780B CN103330780B CN201310317486.7A CN201310317486A CN103330780B CN 103330780 B CN103330780 B CN 103330780B CN 201310317486 A CN201310317486 A CN 201310317486A CN 103330780 B CN103330780 B CN 103330780B
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Abstract
The invention discloses medicine for curing varicose vein of lower limbs and a preparation method thereof. The medicine is mainly prepared from the following raw materials in a certain weight proportion: radix rehmanniae, carthamus tinctorius, fructus aurantii, radix astragali, sophora flavescens and cortex dictamni. The medicine has the functions of clearing heat to remove toxicity, promoting blood circulation to dredge collaterals, removing blood stasis to stop pain, dissipating blood to diminish swelling and removing toxin to promote tissue regeneration, is used for curing varicose vein of lower limbs, and has the advantages of instant effect, good curative effect and high curative ratio.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of varicose veins of the lower extremity and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Varicose veins of the lower extremity is a kind of common disease, is especially more common in the personnel being engaged in lasting physical work or work of standing.The symptoms such as main manifestations is the expansion of lower limb superficial vein, extends, tortuous, and the acid of generation suffering limb is swollen, weak, heavy, severe patient is often with the complication such as ulcus cruris or superficial phlebitis.At present, western medicine varicose veins of the lower extremity poor effect, and have more side effect, therefore, there is great demand to the Chinese medicine of effectively treating varicose veins of the lower extremity in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment varicose veins of the lower extremity, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating varicose veins of the lower extremity.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Rehmanniae, Flos Carthami, Fructus Aurantii, the Radix Astragali, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Portulacae, Rhizoma Atractylodis, Cortex Phellodendri, Lumbricus, Radix Paeoniae Rubra, Radix Bupleuri, Rhizoma Chuanxiong, angelica medicament to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of varicose veins of the lower extremity.Wherein select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Radix Sophorae Flavescentis is selected to be that cold, enter liver, kidney, large intestine, small intestine meridian, have heat clearing away, dampness, the function of parasite killing, controls toxic-heat and blood stasis because its nature and flavor are bitter, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, erosion of vulva pruritus due to damp pathogen, scrofula, scalds.Cortex Dictamni is selected to be because its nature and flavor are bitter, salty, cold, enter spleen, stomach warp, dispel the wind, dampness, heat clearing away, the function of removing toxic substances, control wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice.Select Herba Portulacae to be because its nature and flavor acid, cold, enter large intestine, liver, spleen channel, have heat-clearing and toxic substances removing, the function of loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Cortex Phellodendri is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Rehmanniae 25-35 grams of Flos Carthamis 10-20 grams of Fructus Aurantiis 8-15 grams
The Radix Astragali 15-25 grams of Radix Sophorae Flavescentiss 25-35 grams of Cortex Dictamni 8-15 grams
Herba Portulacae 8-15 grams of Rhizoma Atractylodis 10-20 grams of Cortex Phellodendris 10-20 grams
Lumbricus 8-15 grams of Radix Paeoniae Rubra 8-15 grams of Radix Bupleuri 5-10 grams
Rhizoma Chuanxiong 8-15 grams of Radix Angelicae Sinensis 10-20 grams
Preferable amount is
Radix Rehmanniae 30 grams of Flos Carthamis 15 grams of Fructus Aurantiis 10 grams
The Radix Astragali 20 grams of Radix Sophorae Flavescentiss 30 grams of Cortex Dictamni 10 grams
Herba Portulacae 10 grams of Rhizoma Atractylodis 15 grams of Cortex Phellodendris 15 grams
Lumbricus 10 grams of Radix Paeoniae Rubra 10 grams of Radix Bupleuri 8 grams
Rhizoma Chuanxiong 10 grams of Radix Angelicae Sinensis 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
2, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
3, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and can pinch doubling for degree with hands, section, dries;
4, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
5, Radix Sophorae Flavescentis: pick clean impurity, removes residual stem, cleans earth, is soaked in water, pulls out, run through, and section, dries;
6, Cortex Dictamni: pick clean impurity, removing rough bark, cleans, slightly moistens, and section, dries;
7, Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
8, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;
9, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
10, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
11, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
12, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
13, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
14, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried.
Two, prepare
1, the Radix Rehmanniae of described weight, Flos Carthami, Fructus Aurantii, the Radix Astragali, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Portulacae, Rhizoma Atractylodis, Cortex Phellodendri, Lumbricus, Radix Paeoniae Rubra, Radix Bupleuri, Rhizoma Chuanxiong, angelica medicament are decocted with water twice, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 25 minutes, filters to obtain second time decoction liquor.
3, twice decoction liquor is carried out mixing and stirring, then use slow fire boiling 15 minutes, be divided into by medicinal liquid 6 doses to take.
Medicine of the present invention has heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, activating QI to alleviate the depression, loose blood detumescence, and the function of promoting pus discharge and tissue regeneration strengthening, is used for the treatment of varicose veins of the lower extremity, short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 40, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 20, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy varicose veins of the lower extremity of the present invention
1, physical data
Accept out-patient's totally 120 examples for medical treatment.
2, diagnostic criteria
(1) at lower limb especially at shank, superficial vein swells, and expansion is bending, even curling agglomerating;
(2) patient often feels has shank acid swollen, weak;
(3) there is foot edema after standing for a long time;
(4) late period, shank and skin of ankle often have brown pigment calmness and eczema, and slight damage often can cause the prolonged chronic ulcer do not healed.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, body constitution recovers normal, observes half a year without recidivist;
Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy varicose veins of the lower extremity patient 120 example of the present invention, effective 115 examples of result, obvious effective rate is 95.83%, and take a turn for the better 3 examples, and improvement rate is 2.5%, and invalid 2 examples, total effective rate is 98.33%.
Claims (3)
1. treat a medicine for varicose veins of the lower extremity, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Rehmanniae 25-35 grams of Flos Carthamis 10-20 grams of Fructus Aurantiis 8-15 grams
The Radix Astragali 15-25 grams of Radix Sophorae Flavescentiss 25-35 grams of Cortex Dictamni 8-15 grams
Herba Portulacae 8-15 grams of Rhizoma Atractylodis 10-20 grams of Cortex Phellodendris 10-20 grams
Lumbricus 8-15 grams of Radix Paeoniae Rubra 8-15 grams of Radix Bupleuri 5-10 grams
Rhizoma Chuanxiong 8-15 grams of Radix Angelicae Sinensis 10-20 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Rehmanniae 30 grams of Flos Carthamis 15 grams of Fructus Aurantiis 10 grams
The Radix Astragali 20 grams of Radix Sophorae Flavescentiss 30 grams of Cortex Dictamni 10 grams
Herba Portulacae 10 grams of Rhizoma Atractylodis 15 grams of Cortex Phellodendris 15 grams
Lumbricus 10 grams of Radix Paeoniae Rubra 10 grams of Radix Bupleuri 8 grams
Rhizoma Chuanxiong 10 grams of Radix Angelicae Sinensis 15 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
(2) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(3) Fructus Aurantii: removing flesh, core, cleans, slightly soaks, pull out, soften, and can pinch doubling for degree with hands, section, dries;
(4) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(5) Radix Sophorae Flavescentis: pick clean impurity, removes residual stem, cleans earth, is soaked in water, pulls out, run through, and section, dries;
(6) Cortex Dictamni: pick clean impurity, removing rough bark, cleans, slightly moistens, and section, dries;
(7) Herba Portulacae: pick clean impurity, removing undesirable root, slightly moisten with water, cutting is dried;
(8) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;
(9) Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
(10) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
(11) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
(12) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
(13) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(14) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(2) prepare
(1) Radix Rehmanniae of described weight, Flos Carthami, Fructus Aurantii, the Radix Astragali, Radix Sophorae Flavescentis, Cortex Dictamni, Herba Portulacae, Rhizoma Atractylodis, Cortex Phellodendri, Lumbricus, Radix Paeoniae Rubra, Radix Bupleuri, Rhizoma Chuanxiong, angelica medicament are decocted with water twice, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;
(2) add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 25 minutes, filters to obtain second time decoction liquor;
(3) twice decoction liquor is carried out mixing and stirring, then use slow fire boiling 15 minutes, be divided into by medicinal liquid 6 doses to take.
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| CN201310317486.7A CN103330780B (en) | 2013-07-26 | 2013-07-26 | Medicine for curing varicose vein of lower limb and preparation method thereof |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840641A (en) * | 2015-04-23 | 2015-08-19 | 梁文荣 | Foot bath traditional Chinese medicine for treating obesity induced varicosity |
| CN107198763A (en) * | 2016-03-12 | 2017-09-26 | 杨甫进 | A kind of external application Chinese medicine for preventing and treating shank vein varicose and preparation method thereof |
| CN105853822A (en) * | 2016-04-29 | 2016-08-17 | 张彬彬 | Drug for treating varicose vein of lower limbs |
| CN106110253A (en) * | 2016-07-21 | 2016-11-16 | 马千里 | A kind of Chinese medicine composition treating varicose veins of the lower extremity |
| CN105999208A (en) * | 2016-08-17 | 2016-10-12 | 张彬彬 | Traditional Chinese medicine composition for treating varicose veins of lower limbs |
| CN106110215A (en) * | 2016-08-17 | 2016-11-16 | 张彬彬 | A kind of medicine treating varicose veins of the lower extremity |
| CN106139110A (en) * | 2016-09-01 | 2016-11-23 | 马千里 | A kind of Chinese medicine composition for treating varicose veins of the lower extremity |
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| CN101199642A (en) * | 2007-12-19 | 2008-06-18 | 于殿安 | Chinese medicine agent for treating lower limbs vein curves |
| CN102370768A (en) * | 2010-08-20 | 2012-03-14 | 高英豪 | Traditional Chinese medicinal composition for treating varicose veins |
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Patent Citations (2)
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|---|---|---|---|---|
| CN101199642A (en) * | 2007-12-19 | 2008-06-18 | 于殿安 | Chinese medicine agent for treating lower limbs vein curves |
| CN102370768A (en) * | 2010-08-20 | 2012-03-14 | 高英豪 | Traditional Chinese medicinal composition for treating varicose veins |
Non-Patent Citations (2)
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| 周围血管病的外治法与体位疗法;张学颖;《四川中医》;20021231;第20卷(第9期);17-18 * |
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