CN105031310A

CN105031310A - Medicine for treating wind-cold-dampness arthralgia and preparation method thereof

Info

Publication number: CN105031310A
Application number: CN201510510369.1A
Authority: CN
Inventors: 王莉
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-08-20
Filing date: 2015-08-20
Publication date: 2015-11-11

Abstract

The invention discloses a medicine for treating wind-cold-dampness arthralgia and a preparation method thereof. The medicine is mainly prepared from pinellia ternata, rhizoma cimicifugae, rhizoma atractylodis macrocephalae, rhizoma smilacis glabrae, frankincense, herba taxilli, spatholobus suberctu, radix clematidis, radix angelicae pubescentis, schizophragma integrifolium and lycopodium clavatum in a certain weight ratio. The medicine has functions of clearing heat, removing toxicity, resolving mass, diminishing swelling, strengthening tendons and bones, removing wind-dampness, clearing and activating the channels and collaterals, and has the advantages of quick acting, short course of treatment and no side effect when used for treating wind-cold-dampness arthralgia.

Description

A kind of medicine for the treatment of anemofrigid-damp arthralgia and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of anemofrigid-damp arthralgia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Anemofrigid-damp arthralgia is exopathogen invasion and attack meridians, and QI and blood impatency is smooth, cause the place such as joint, limbs occur acid, bitterly, fiber crops, the symptom such as heavy and joint stuffiness.Rheumatic fever, rheumatic arthritis, rheumatoid arthritis, fibrositis and neuralgia etc. can be comprised.At present, western medicine anemofrigid-damp arthralgia poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating anemofrigid-damp arthralgia in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment anemofrigid-damp arthralgia, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating anemofrigid-damp arthralgia.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Olibanum, Herba Taxilli, Caulis Spatholobi, Radix Clematidis, Radix Angelicae Pubescentis, Cortex schizophragmatis integrifolii radicis, Herba Lycopodii, Radix Aconiti Lateralis Preparata, Caulis Piperis Kadsurae, Herba Pyrolae, Herba speranskiae tuberculatae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Lignum Pini Nodi, Rhizoma Gastrodiae, Stigma Croci, Radix Rubiae, Agkistrodon, Flos Lonicerae, Folium Cinnamomi burmannii, Foliumet Ramulus Evodiae, Fructus Forsythiae, Cortex Phellodendri medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating anemofrigid-damp arthralgia.Wherein select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Rhizoma Smilacis Glabrae to be because its property slightly sweet flavor, flat, enter liver, stomach warp, have removing toxic substances, dehumidifying, the function in sharp joint, controls syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle, carbuncle, scrofula.Select Olibanum to be that temperature, enters the heart, liver, spleen channel, have regulating qi and activating blood, analgesic therapy because its nature and flavor are worked hard, chase after the function of poison, control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, have wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Radix Angelicae Pubescentis to be that temperature, enters kidney, urinary bladder channel, dispel the wind because its nature and flavor are worked hard, victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Cortex schizophragmatis integrifolii radicis is selected to be that dispelling the wind and dampness pathogens beriberi, extremities joint is ached because it is cool in nature, lightly seasoned.Select Herba Lycopodii to be because its nature and flavor toil, temperature, enters liver, stomach, kidney three warp, has expelling wind and cold, and dehumidifying detumescence, the function of relaxing muscles and tendons to promote blood circulation, controls anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.Radix Aconiti Lateralis Preparata is selected to be because its property acrid-sweet flavor, heat, poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Caulis Piperis Kadsurae is selected to be that tepor, enter the heart, kidney two warp, have wind-damp dispelling, the meridian dredging, the function of regulating the flow of vital energy, controls anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough because its nature and flavor are worked hard.Select Herba Pyrolae to be because its nature and flavor sweetness and bitterness, temperature, enters liver, kidney two warp, has tonify deficiency, kidney tonifying, expelling wind and removing dampness, the function of promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage.Select Herba speranskiae tuberculatae to be because its property and flavor of peppery and warm, dispel the wind, dehumidifying, relaxing muscles and tendons, invigorates blood circulation, the function of pain relieving, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, skin ulcer tinea toxic swelling.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, life uses dissipating blood stasis blood, subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Radix Gentianae Macrophyllae is selected to be because its nature and flavor toil, flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Rhizoma Et Radix Notopterygii is selected to be that temperature, enter bladder, kidney channel, have loose exterior cold, wind-damp dispelling, the function in sharp joint, cure cold wind and cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore because its nature and flavor are worked hard.Select Lignum Pini Nodi to be that temperature, enters the heart, lung two warp, dispel the wind, dampness, relaxing muscles and tendons, the function of dredging collateral because its nature and flavor are bitter, control severe and migratory arthralgia pain, convulsion contraction is anxious, and beriberi flaccidity is soft, the arthroncus of knee, falls damage blood stasis.Select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, have endogenous wind stopping, the function of arresting convulsion, control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, little Jing Epilepsy wind symptom.Select Stigma Croci to be that flat, enter the heart, Liver Channel, have blood circulation promoting and blood stasis dispelling, the function of dispersing stagnation and relieving accumulation of pathogens, control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed because its nature and flavor are sweet, spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.Radix Rubiae is selected to be that cold, enter the heart, Liver Channel, have promoting the circulation of blood to stop blooding, dredge the meridian passage, eliminating phlegm and stopping cough, control haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, property tracheitis because its nature and flavor are bitter.Agkistrodon is selected to be that temperature, poisonous, return Liver Channel, dispel the wind, active, spasmolytic, the function of counteracting toxic substances, controls hemiplegia, numb limbs and tense tendons, tic spasm, tetanus, rheumatoid arthritis stubborn, arthralgia, poliomyelitis convalescent period because its nature and flavor are sweet, salty.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Folium Cinnamomi burmannii is selected to be because its nature and flavor are pungent, dispelling the wind and dampness pathogens osteodynia, cold-damp dysentery, stomachache.Select Foliumet Ramulus Evodiae to be because its nature and flavor are bitter, cold, have heat clearing away, removing toxic substances, dispel the wind, the function of dehumidifying, controls laryngopharynx swelling and pain, malaria, icterohepatitis, rheumatic ostalgia, eczema, dermatitis, skin infection.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Cortex Phellodendri is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Rhizoma Pinelliae 5-15 gram liter fiber crops 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram

Rhizoma Smilacis Glabrae 25-35 gram of Olibanum 10-20 gram of Herba Taxilli 10-20 gram

Caulis Spatholobi 5-15 gram of Radix Clematidis 15-25 gram of Radix Angelicae Pubescentis 25-35 gram

Cortex schizophragmatis integrifolii radicis 5-15 gram of Herba Lycopodii 10-20 gram of Radix Aconiti Lateralis Preparata 10-20 gram

Caulis Piperis Kadsurae 5-15 gram of Herba Pyrolae 10-20 gram of Herba speranskiae tuberculatae 15-25 gram

Radix Achyranthis Bidentatae 25-35 gram of Radix Gentianae Macrophyllae 15-25 gram of Radix Paeoniae Rubra 15-25 gram

Rhizoma Et Radix Notopterygii 10-20 gram of Lignum Pini Nodi 15-25 gram of Rhizoma Gastrodiae 5-15 gram

Stigma Croci 5-15 gram of Radix Rubiae 10-20 gram of Agkistrodon 6-10 gram

Flos Lonicerae 10-20 gram of Folium Cinnamomi burmannii 15-25 gram of Foliumet Ramulus Evodiae 20-30 gram

Fructus Forsythiae 5-15 gram of Cortex Phellodendri 5-15 gram

Preferable amount is

The Rhizoma Pinelliae 10 gram liter fiber crops 20 grams of Rhizoma Atractylodis Macrocephalaes 20 grams

Rhizoma Smilacis Glabrae 30 grams of Olibanums 15 grams of Herba Taxillis 15 grams

Caulis Spatholobi 10 grams of Radix Clematidis 20 grams of Radix Angelicae Pubescentiss 30 grams

Cortex schizophragmatis integrifolii radicis 10 grams of Herba Lycopodiis 15 grams of Radix Aconiti Lateralis Preparatas 15 grams

Caulis Piperis Kadsurae 10 grams of Herba Pyrolaes 15 grams of Herba speranskiae tuberculataes 20 grams

Radix Achyranthis Bidentatae 30 grams of Radix Gentianae Macrophyllae 20 grams of Radix Paeoniae Rubra 20 grams

10 grams, Rhizoma Et Radix Notopterygii 15 grams of Lignum Pini Nodis 20 grams of Rhizoma Gastrodiaes

Stigma Croci 10 grams of Radix Rubiae 15 grams of Agkistrodons 8 grams

Flos Lonicerae 15 grams of Folium Cinnamomi burmanniis 20 grams of Foliumet Ramulus Evodiaes 25 grams

Fructus Forsythiae 10 grams of Cortex Phellodendris 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

2, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

3, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

4, Rhizoma Smilacis Glabrae: with water logging drift, change water every day in summer 1 time, spring, every 2 days of autumn change water 1 time, and winter can change water on the 3rd 1 time, prevents smelly, till soaking, pulls section out, dry in time;

5, Olibanum: pick the sub-impurity of shakeout;

6, Herba Taxilli: wash, runs through, and cutting is dried;

7, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

8, Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

9, Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;

10, Cortex schizophragmatis integrifolii radicis: the whole year can adopt, and takes root, strips root bark, dries;

11, Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment;

12, Radix Aconiti Lateralis Preparata: be soaked in water, pulls out, and section, dries;

13, Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, take out and put profit 16-24 hour in square-bottomed bamboo basket, section, dries;

14, Herba Pyrolae: pick decontamination, sieve removes silt, cleans, slightly moistens, chop up, dry;

15, Herba speranskiae tuberculatae: pick clean impurity, cutting;

16, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

17, Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;

18, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

19, Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;

20, Lignum Pini Nodi: thumb is broken, washes, and soaks, pulls out, run through, treat soft section, dry;

21, Rhizoma Gastrodiae: be laid in by Rhizoma Gastrodiae slice and sprayed on the watch core paper of water, put in pot, burns sallow to paper color with slow fire, is constantly stirred by tablet to the strong yellow of two sides;

22, Stigma Croci: pick decontamination, and remove yellow feeler;

23, Radix Rubiae: pick clean impurity, cleans, runs through rear timely section, dry;

24, Agkistrodon: get crude drug, brush away ash bits, the used time decaptitates, squama, cutting;

25, Flos Lonicerae: sieve removes silt, picks clean impurity;

26, Folium Cinnamomi burmannii: pick clean impurity, dry;

27, Foliumet Ramulus Evodiae: pick clean impurity, dry;

28, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

29, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;

Two, prepare

1, the Rhizoma Pinelliae of described weight, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Olibanum, Herba Taxilli, Caulis Spatholobi, Radix Clematidis, Radix Angelicae Pubescentis, Cortex schizophragmatis integrifolii radicis, Herba Lycopodii, Radix Aconiti Lateralis Preparata, Caulis Piperis Kadsurae, Herba Pyrolae, Herba speranskiae tuberculatae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Lignum Pini Nodi, Rhizoma Gastrodiae, Stigma Croci, Radix Rubiae, Agkistrodon, Flos Lonicerae, Folium Cinnamomi burmannii, Foliumet Ramulus Evodiae, Fructus Forsythiae, Cortex Phellodendri are decocted secondary, add water 8 times amount for the first time, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor;

2, add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

3, merge twice and decoct medicinal liquid, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 6 doses to take decoction medicinal liquid.

Medicine of the present invention has heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, bone and muscle strengthening, and except rheumatism, the function of dredge the meridian passage, is used for the treatment of anemofrigid-damp arthralgia, short treating period, instant effect, has no side effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 15 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy anemofrigid-damp arthralgia of the present invention

1, physical data

Accept anemofrigid-damp arthralgia patient totally 38 examples for medical treatment.

2, diagnostic criteria

Anemofrigid-damp arthralgia clinical manifestation: joint aches or the heavy numbness of part muscle acid, with the passing of time delay can cause limbs contracture, very then arthroncus.

Following three types can be divided into

Migratory arthralgia: limbs joint is walked to alter pain, migratory pain has cold and heat concurrently sometimes, yellowish fur, floating pulse.

Arthralgia aggravated by cold: all over or local arthralgia, localized pain, obtains hot slightly slow, meets cold then acute, tongue the lung-pulse stringy and tense pulse.

: joint aches, numbness of the skin, localized pain, wet weather is air-cooled often can make it show effect, and tongue is greasy in vain, relaxed and soft pulse.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 15 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: anemofrigid-damp arthralgia symptom disappears, observe half a year without bounce-back person;

Take a turn for the better: arthralgia alleviates, feeling of numbness disappears, and anemofrigid-damp arthralgia symptom is obviously improved, and body constitution progressively strengthens;

Invalid: anemofrigid-damp arthralgia symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy anemofrigid-damp arthralgia patient 38 example of the present invention, effective 33 examples of result, obvious effective rate is 86.84%, and take a turn for the better 4 examples, and improvement rate is 10.53%, and invalid 1 example, total effective rate is 97.37%.

Claims

1. treat a medicine for anemofrigid-damp arthralgia, it is characterized in that: it is made up of the crude drug in following weight range: