CN103638448B - Medicine used for treating rheumatoid arthritis, and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine used for treating rheumatoid arthritis, and a preparation method thereof. The medicine is prepared form medical ingredients such asligusticum, siegesbeckia orientalis, cortex cinnamomi, radix clematidis, rhizoma bletillae, chloranthus serratus, pungent litse fruit root, camphor tree fruit, folium artemisiae argyi, and stiff silkworm according to a certain weight ratio. The medicine is capable of activating blood circulation and dredging collaterals, dispelling wind and eliminating dampness, replenishing blood and relaxing muscles and tendons, and dispelling cold and relieving pain. Treatment effect on rheumatoid arthritis is realized quickly, treatment course is short, and rheumatoid arthritis is prevented from relapsing.

Description

A kind of medicine for the treatment of rheumatic arthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of rheumatic arthritis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Rheumatic arthritis is a kind of common acute or chronic ICT.Can recurrent exerbation involve heart.Clinical with joint and muscle migrans miserable, heavily work, pain is for feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.Typical performance is slight or moderate heating, migratory polyarthritis, affected joints mostly is the large joint such as knee joint, ankle, shoulder, elbow, wrist, is commonly transferred to another joint by a joint; pathological changes local presents red, swollen, scorching hot, severe pain, and some patients also has several joint to fall ill simultaneously.Atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappeared in 2 ~ 4 weeks, did not stay sequela, but normal recurrent exerbation.If active rheumatism affects heart, then can there is myocarditis, even leave over valve disorder.Because Western medicine effectively cannot treat rheumatic arthritis, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating rheumatic arthritis.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment rheumatic arthritis, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating rheumatic arthritis.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Rhizoma Ligustici, Herba Siegesbeckiae, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, Herba Epimedii medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of rheumatic arthritis.Rhizoma Ligustici is wherein selected to be that temperature, returns urinary bladder channel, have cold expelling to dispel the wind, the function of removing damp and stopping pain because its nature and flavor are pungent, for anemofrigid cold, top, mountain peak pain.Xuan Herba Siegesbeckiae is that cold, enter liver,spleen,kidney warp, have wind-damp dispelling, relieving rigidity of muscles and joints, the function of blood pressure lowering, controls quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin, traumatic hemorrhage because its nature and flavor are bitter.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, have wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor, cool, enter lung meridian, have tonifying the lung, hemostasis, detumescence, raw sight, the function of sore, control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.Caulis et Folium chloranthi serrati is selected to be that flat, poisonous, have expelling wind and cold, promoting blood circulation and detumescence, the function of removing toxic substances, cures cold because its nature and flavor are pungent, cough, rheumatalgia, traumatic injury, carbuncle furuncle, menoxenia.Select Radix Litseae pungentis to be because its nature and flavor are pungent, hot in nature, nontoxic, have expelling wind and cold, the function that warming middle-JIAO is regulated the flow of vital energy, control stomachache with cool feeling, Fengshi Guanjie pain.Select Fructus litseae rubescentis to be that acrid in the mouth, has expelling wind and cold, and the function of relieving dyspepsia, controls gastroenteritis because its slightly warm in nature, cold syndrome of the stomach is suffered from abdominal pain, dyspepsia, abdominal distention.Folium Artemisiae Argyi is because its nature and flavor toil, temperature.Enter spleen, liver, kidney channel.To regulate the flow of vital energy blood, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.Bombyx Batryticatus is selected to be because its nature and flavor are pungent, salty, flat, return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Fructus Cnidii is selected to be that temperature, enter kidney, spleen channel, have warming the kidney to activate YANG, dispel the wind, dampness, the function of parasite killing, controls impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, and cold uterus is infertile, rheumatic arthralgia, scabies eczema because its nature and flavor are worked hard.Fructus Psoraleae is selected to be because its nature and flavor are pungent, temperature.Enter kidney channel.Reinforcing the kidney and supporting YANG.Control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Select the Radix Linderae to be that temperature, enters spleen, lung, kidney, urinary bladder channel, have pleasant, dissipating depression of QI, cold expelling, the function of pain relieving, control QI rising in reverse order chest and abdomen swelling and pain because its nature and flavor are pungent, dyspepsia is discontented with, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Caulis Piperis Kadsurae is selected to be that tepor, enter the heart, kidney two warp, have wind-damp dispelling, the meridian dredging, the function of regulating the flow of vital energy, controls anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough because its nature and flavor are worked hard.Rhizoma Et Radix Notopterygii is selected to be that temperature, enter bladder, kidney channel, have loose exterior cold, wind-damp dispelling, the function in sharp joint, cure cold wind and cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore because its nature and flavor are worked hard.Radix Curcumae is selected to be because its nature and flavor are worked hard, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Fructus Evodiae to be because its nature and flavor are worked hard, temperature, poisonous, enter liver, stomach warp, have warming middle-JIAO, pain relieving, regulate the flow of vital energy, the function of dampness, stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Select Oletum Trogopterori to be because its property bitter but sweet flavor, temperature, enters liver, spleen channel, and raw by the function having promoting the circulation of blood pain relieving, control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, stir-fry is stopped blooding, and control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.Select Radix Morindae Officinalis to be because its property acrid-sweet flavor, temperature, enter liver, kidney channel, have kidney-replenishing, strengthening bone and muscle, the function of wind-damp dispelling, controls sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.Select Radix Dipsaci to be that tepor, enters liver, kidney channel, have invigorating the liver and kidney, reuniting the fractured tendons and bones, and the function of blood circulation regulating, controls aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia because its nature and flavor toil, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swells.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, life uses dissipating blood stasis blood, subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Gentianae Macrophyllae is selected to be because its nature and flavor toil, flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select Semen Litchi to be because its property sweet-puckery flavor, temperature, enter liver, kidney channel, have warming middle-JIAO, regulate the flow of vital energy, the function of pain relieving, controls gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.Caulis Trachelospermi is selected to be because its nature and flavor are bitter, cool, enter liver, kidney channel, dispel the wind, dredging collateral, hemostasis, the function of repercussive, dispelling the wind and dampness pathogens arthralgia pain, the contracture of muscle arteries and veins, carbuncle, sore throat, spit blood, traumatic injury, disease that postpartum lochia can't go.Select Rhizoma Homalomenae to be because its nature and flavor are bitter, pungent, temperature, return liver, kidney channel, have wind-damp dispelling, the function of muscle reinforcing and bone strengthening, controls anemofrigid-damp arthralgia, chills and pain of the waist and kness, and lower limb contracture is numb.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Rhizoma Ligustici 10-20 Ke pig Xian 10-20 gram of Cortex Cinnamomi 10-20 gram

Radix Clematidis 10-20 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram of Caulis et Folium chloranthi serrati 10-20 gram

Radix Litseae pungentis 10-20 gram of Fructus litseae rubescentis 5-15 gram of Folium Artemisiae Argyi 5-15 gram

Bombyx Batryticatus 5-15 gram of Fructus Cnidii 5-15 gram of Fructus Psoraleae 5-15 gram

Radix Linderae 5-15 gram of Caulis Piperis Kadsurae 5-15 gram of Rhizoma Et Radix Notopterygii 5-15 gram

Radix Curcumae 15-25 gram of Fructus Evodiae 15-25 gram of Oletum Trogopterori 15-25 gram

Radix Morindae Officinalis 15-25 gram of Radix Dipsaci 15-25 gram of Rhizoma Corydalis 15-25 gram

Radix Achyranthis Bidentatae 15-25 gram of Rhizoma Atractylodis 15-25 gram of Radix Paeoniae Rubra 15-25 gram

Radix Gentianae Macrophyllae 10-20 gram of Semen Litchi 10-20 gram of Caulis Trachelospermi 10-20 gram

Rhizoma Homalomenae 10-20 gram of Herba Epimedii 10-20 gram

Preferable amount is

Rhizoma Ligustici 15 Ke pig Xian 15 grams of Cortex Cinnamomis 15 grams

Radix Clematidis 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams of Caulis et Folium chloranthi serratis 15 grams

Radix Litseae pungentis 15 grams of Fructus litseae rubescentis 10 grams of Folium Artemisiae Argyis 10 grams

Bombyx Batryticatus 10 grams of Fructus Cnidiis 10 grams of Fructus Psoraleaes 10 grams

The Radix Linderae 10 grams of Caulis Piperis Kadsuraes 10 grams of Rhizoma Et Radix Notopterygiis 10 grams

Radix Curcumae 20 grams of Fructus Evodiaes 20 grams of Oletum Trogopteroris 20 grams

Radix Morindae Officinalis 20 grams of Radix Dipsacis 20 grams of Rhizoma Corydalis 20 grams

Radix Achyranthis Bidentatae 20 grams of Rhizoma Atractylodis 20 grams of Radix Paeoniae Rubra 20 grams

Radix Gentianae Macrophyllae 15 grams of Semen Litchis 15 grams of Caulis Trachelospermis 15 grams

Rhizoma Homalomenae 15 grams of Herba Epimedii 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Ligustici: get crude drug, removing impurity, size stepping, wash quickly is clean, runs through, and section, dries;

2, Herba Siegesbeckiae: pick decontamination, removing undesirable root with always obstruct, first tremble inferior lobe and separately put, stalk is clean, be soaked in water, pull out, run through rear section, dry, then with leaf and even;

3, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

4, Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

5, Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, dries in the air even to inside and outside humidity, and section is dry;

6, Caulis et Folium chloranthi serrati: spring, summer gather, and pick decontamination, dry;

7, Radix Litseae pungentis: the 8-10 month excavates, cleans, and section, dries;

8, Fructus litseae rubescentis: the 8-9 month plucks, and picks decontamination, dries;

9, Folium Artemisiae Argyi: pick decontamination, destemming, sieve dedust bits;

10, Bombyx Batryticatus: get crude drug, removes residual silk, impurity;

11, Fructus Cnidii: pick decontamination, sieve removes silt particle, cleans, dries;

12, Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;

13, the Radix Linderae: pick decontamination, separately size bar, saturating with blister, changing water according to noting season, preventing smelly, pulling section out in time, sieve dedust bits;

14, Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, take out and put profit 16-24 hour in square-bottomed bamboo basket, section, dries;

15, Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;

16, Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;

17, Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;

18, Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

19, Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;

20, Radix Dipsaci: clean silt, removing retained root head, runs through rear section and dries, sieve anti-dandruff;

21, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

22, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

23, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

24, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

25, Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;

26, Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

27, Caulis Trachelospermi: wash earth with water, picks clean impurity, slightly soaks, run through, and cuts off, dries;

28, Rhizoma Homalomenae: removing impurity, cleans, runs through, shave, and dry, sieve removes chip;

29, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip.

Two, prepare

1, the Rhizoma Ligustici, Herba Siegesbeckiae of described weight, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, Herba Epimedii medicine are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 15 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor.

2, add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 30 minutes, filter and to obtain second time decoction liquor.

3, by twice decoction liquor mixing, 6 doses are divided into take.

Medicine of the present invention has promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness, and blood relaxing muscles and tendons, effect of dispersing cold for relieving pain, and treatment rheumatic arthritis instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 230 example for medical treatment.

2, diagnostic criteria

Clinical manifestation: rheumatic arthritis is the one performance of rheumatic fever.Rheumatic fever is the whole body allergic disease caused by A group beta hemolytic streptococcus infects, and onset of disease has erysipelas etc. to infect medical history often.Rheumatic fever onset is anxious, and is more common in teenager.Rheumatic arthritis can invade heart, causes rheumatic heart disease, and has the performances such as heating, subcutaneous nodule and erythra.Rheumatic arthritis has two features: one is that joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change is usually the large joints of lower limb such as knee joint, hip, ankle, and be secondly shoulder, elbow, carpal joint, the Minor articulus of brothers is rare; Two is that pain migration is indefinite, and a period of time is the outbreak of this joint, and a period of time is that joint is uncomfortable, and blood chemical examination erythrocyte sedimentation rate is accelerated, and anti-" 0 " titre raises, rheumatoid factor negative.Some patients can leave over heart change.Arthralgia is the modal symptom of rheumatism, and general joint all likely pain occurs, but the pain of limbs and metastomium and internal organs and neural pathological changes may be caused.Muscle also there will be pain symptom, but also may occur the rising of myasthenia, creatase, Myopathic lesion etc., as systemic lupus erythematosus (sle), mixed connective tissue disease, dermatomyositis etc.Rheumatism there will be irregular fever phenomenon before occurring, there will not be phenomenon of shivering, invalid with antibiotic therapy, also there will be erythrocyte sedimentation rate fast, as systemic lupus erythematosus (sle), acute neutrophilia heat generation skin disease, be grown up this Supreme Being you disease, panniculitis etc. all can generate heat for onset symptoms simultaneously.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 5 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: rheumatic arthritis is eliminated, without recurring after observing half a year;

Take a turn for the better: rheumatic arthritis symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy rheumatoid arthritis patients 170 example of the present invention, effective 222 examples of result, obvious effective rate is 96.52%, and take a turn for the better 5 examples, and improvement rate is 2.17%, and invalid 3 examples, total effective rate is 98.69%.

Claims (3)

1. treat a medicine for rheumatic arthritis, it is characterized in that: it is made up of the crude drug in following weight range:

Rhizoma Ligustici 10-20 Ke pig Xian 10-20 gram of Cortex Cinnamomi 10-20 gram

Radix Clematidis 10-20 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram of Caulis et Folium chloranthi serrati 10-20 gram

Radix Litseae pungentis 10-20 gram of Fructus litseae rubescentis 5-15 gram of Folium Artemisiae Argyi 5-15 gram

Bombyx Batryticatus 5-15 gram of Fructus Cnidii 5-15 gram of Fructus Psoraleae 5-15 gram

Radix Linderae 5-15 gram of Caulis Piperis Kadsurae 5-15 gram of Rhizoma Et Radix Notopterygii 5-15 gram

Radix Curcumae 15-25 gram of Fructus Evodiae 15-25 gram of Oletum Trogopterori 15-25 gram

Radix Morindae Officinalis 15-25 gram of Radix Dipsaci 15-25 gram of Rhizoma Corydalis 15-25 gram

Radix Achyranthis Bidentatae 15-25 gram of Rhizoma Atractylodis 15-25 gram of Radix Paeoniae Rubra 15-25 gram

Radix Gentianae Macrophyllae 10-20 gram of Semen Litchi 10-20 gram of Caulis Trachelospermi 10-20 gram

Rhizoma Homalomenae 10-20 gram of Herba Epimedii 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Rhizoma Ligustici 15 Ke pig Xian 15 grams of Cortex Cinnamomis 15 grams

Radix Clematidis 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams of Caulis et Folium chloranthi serratis 15 grams

Radix Litseae pungentis 15 grams of Fructus litseae rubescentis 10 grams of Folium Artemisiae Argyis 10 grams

Bombyx Batryticatus 10 grams of Fructus Cnidiis 10 grams of Fructus Psoraleaes 10 grams

The Radix Linderae 10 grams of Caulis Piperis Kadsuraes 10 grams of Rhizoma Et Radix Notopterygiis 10 grams

Radix Curcumae 20 grams of Fructus Evodiaes 20 grams of Oletum Trogopteroris 20 grams

Radix Morindae Officinalis 20 grams of Radix Dipsacis 20 grams of Rhizoma Corydalis 20 grams

Radix Achyranthis Bidentatae 20 grams of Rhizoma Atractylodis 20 grams of Radix Paeoniae Rubra 20 grams

Radix Gentianae Macrophyllae 15 grams of Semen Litchis 15 grams of Caulis Trachelospermis 15 grams

Rhizoma Homalomenae 15 grams of Herba Epimedii 15 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Ligustici: get crude drug, removing impurity, size stepping, wash quickly is clean, runs through, and section, dries;

(2) Herba Siegesbeckiae: pick decontamination, removing undesirable root with always obstruct, first tremble inferior lobe and separately put, stalk is clean, be soaked in water, pull out, run through rear section, dry, then with leaf and even;

(3) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

(4) Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

(5) Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, dries in the air even to inside and outside humidity, and section is dry;

(6) Caulis et Folium chloranthi serrati: spring, summer gather, and pick decontamination, dry;

(7) Radix Litseae pungentis: the 8-10 month excavates, cleans, and section, dries;

(8) Fructus litseae rubescentis: the 8-9 month plucks, and picks decontamination, dries;

(9) Folium Artemisiae Argyi: pick decontamination, destemming, sieve dedust bits;

(10) Bombyx Batryticatus: get crude drug, removes residual silk, impurity;

(11) Fructus Cnidii: pick decontamination, sieve removes silt particle, cleans, dries;

(12) Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;

(13) Radix Linderae: pick decontamination, separately size bar, saturating with blister, changing water according to noting season, preventing smelly, pulling section out in time, sieve dedust bits;

(14) Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, take out and put profit 16-24 hour in square-bottomed bamboo basket, section, dries;

(15) Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;

(16) Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;

(17) Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;

(18) Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

(19) Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;

(20) Radix Dipsaci: clean silt, removing retained root head, runs through rear section and dries, sieve anti-dandruff;

(21) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(22) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(23) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

(24) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

(25) Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;

(26) Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

(27) Caulis Trachelospermi: wash earth with water, picks clean impurity, slightly soaks, run through, and cuts off, dries;

(28) Rhizoma Homalomenae: removing impurity, cleans, runs through, shave, and dry, sieve removes chip;

(29) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(2) prepare

(1) the Rhizoma Ligustici, Herba Siegesbeckiae of described weight, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, Herba Epimedii medicine are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 15 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor;

(2) add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 30 minutes, filter and to obtain second time decoction liquor;

(3) by twice decoction liquor mixing, 6 doses are divided into take.