CN103638448A - Medicine used for treating rheumatoid arthritis, and preparation method thereof - Google Patents
Medicine used for treating rheumatoid arthritis, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine used for treating rheumatoid arthritis, and a preparation method thereof. The medicine is prepared form medical ingredients such asligusticum, siegesbeckia orientalis, cortex cinnamomi, radix clematidis, rhizoma bletillae, chloranthus serratus, pungent litse fruit root, camphor tree fruit, folium artemisiae argyi, and stiff silkworm according to a certain weight ratio. The medicine is capable of activating blood circulation and dredging collaterals, dispelling wind and eliminating dampness, replenishing blood and relaxing muscles and tendons, and dispelling cold and relieving pain. Treatment effect on rheumatoid arthritis is realized quickly, treatment course is short, and rheumatoid arthritis is prevented from relapsing.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatic arthritis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Rheumatic arthritis is a kind of common acute or chronic ICT.Can repeatedly show effect and involve heart.Clinical take joint and muscle migration is miserable, heavily work, pain is feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.Typical case's performance is slight or moderate heating, migratory polyarthritis, the joint of getting involved mostly is the large joint such as knee joint, ankle, shoulder, elbow, wrist, commonly by a joint, is transferred to another joint; pathological changes part presents red, swollen, scorching hot, severe pain, and part patient also has several joints to fall ill simultaneously.Atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappeared in 2～4 weeks, did not stay sequela, but Chang Fanfu outbreak.If active rheumatism affects heart, can there is myocarditis, even leave over valve disorder.Because Western medicine cannot effectively be treated rheumatic arthritis, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment rheumatic arthritis.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment rheumatic arthritis, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat rheumatic arthritis.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Rhizoma Ligustici, Herba Siegesbeckiae, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, Herba Epimedii medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of rheumatic arthritis.Wherein select Rhizoma Ligustici to be because its nature and flavor are pungent, temperature, returns urinary bladder channel, has cold expelling to dispel the wind, the function of removing damp and stopping pain, and for anemofrigid cold, top, mountain peak pain.Xuan Herba Siegesbeckiae is because its nature and flavor are bitter, cold, enters liver,spleen,kidney warp, has wind-damp dispelling, relieving rigidity of muscles and joints, and the function of blood pressure lowering, controls quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin, traumatic hemorrhage.Selecting Cortex Cinnamomi is that heat, enters kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, there is wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor is cool, enter lung meridian, have tonifying the lung, hemostasis, detumescence, raw sight, the function of sore, controls lung and hinders hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, soup fire is burnt, rhagadia manus et pedis.Select Caulis et Folium chloranthi serrati to be because its nature and flavor are pungent, flat, poisonous, there is expelling wind and cold, promoting blood circulation and detumescence, the function of removing toxic substances, cures cold, cough, rheumatalgia, traumatic injury, carbuncle furuncle, menoxenia.Select Radix Litseae pungentis to be because its nature and flavor are pungent, hot in nature, nontoxic, have expelling wind and cold, the function that warming middle-JIAO is regulated the flow of vital energy, controls stomachache with cool feeling, Fengshi Guanjie pain.Selecting Fructus litseae rubescentis is that acrid in the mouth, has expelling wind and cold because of its slightly warm in nature, and the function of relieving dyspepsia, controls gastroenteritis, cold syndrome of the stomach stomachache, dyspepsia, abdominal distention.Folium Artemisiae Argyi is because of its nature and flavor toil, temperature.Enter spleen, liver, kidney channel.The blood of regulating the flow of vital energy, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, the convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.Select Bombyx Batryticatus to be because its nature and flavor are pungent, salty, flat, return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Select Fructus Cnidii to be because its nature and flavor are arduous, temperature, enters kidney, spleen channel, has warming the kidney to activate YANG, dispel the wind, and dampness, the function of parasite killing, controls impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.Select Fructus Psoraleae to be because its nature and flavor are pungent, temperature.Enter kidney channel.Reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Select the Radix Linderae to be because its nature and flavor are pungent, temperature, enters spleen, lung, kidney, urinary bladder channel, have pleasant, dissipating depression of QI, cold expelling, the function of pain relieving, controls QI rising in reverse order chest and abdomen swelling and pain, dyspepsia is discontented, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Select Caulis Piperis Kadsurae to be because its nature and flavor are arduous, tepor, enters the heart, kidney two warps, has wind-damp dispelling, the meridian dredging, and the function of regulating the flow of vital energy, controls anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.Select Rhizoma Et Radix Notopterygii to be because its nature and flavor are arduous, temperature, enters bladder, kidney channel, has loose exterior cold, wind-damp dispelling, and the function in sharp joint, the wind and cold that cures cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.Select Radix Curcumae to be because its nature and flavor are arduous, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Fructus Evodiae to be because its nature and flavor are arduous, temperature, poisonous, enter liver, stomach warp, there is warming middle-JIAO, pain relieving, regulates the flow of vital energy, the function of dampness, stopping vomiting is against acid regurgitation, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Selecting Oletum Trogopterori is that temperature, enters liver, spleen channel because of its property bitter but sweet flavor, and the raw function with there being promoting the circulation of blood pain relieving, controls all pains of trusted subordinate's vim and vigour, women's amenorrhea, and postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, fry with hemostasis, controls metrorrhagia, menorrhagia, and leucorrhea with bloody discharge is without cease.Selecting Radix Morindae Officinalis is that temperature, enters liver, kidney channel, has kidney-replenishing because of its property acrid-sweet flavor, strengthening bone and muscle, and the function of wind-damp dispelling, controls sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.Selecting Radix Dipsaci is that tepor, enters liver, kidney channel, has invigorating the liver and kidney because of its nature and flavor toil, reuniting the fractured tendons and bones, and the function of blood circulation regulating, controls aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer is swollen.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulates the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enters spleen, stomach warp, has spleen invigorating, dampness, and resolving depression, wards off dirty function, control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Radix Gentianae Macrophyllae to be because its nature and flavor toil is flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Selecting Semen Litchi is that temperature, enters liver, kidney channel, has warming middle-JIAO, regulates the flow of vital energy because of its property sweet-puckery flavor, and the function of pain relieving, controls gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.Select Caulis Trachelospermi to be because its nature and flavor are bitter, cool, enter liver, kidney channel, dispel the wind, dredging collateral, hemostasis, the function of repercussive, dispelling the wind and dampness pathogens arthralgia pain, the contracture of muscle arteries and veins, carbuncle, sore throat, spits blood, traumatic injury, disease that postpartum lochia can't go.Select Rhizoma Homalomenae to be because its nature and flavor are bitter, pungent, temperature, returns liver, kidney channel, has wind-damp dispelling, and the function of muscle reinforcing and bone strengthening, controls anemofrigid-damp arthralgia, chills and pain of the waist and kness, and lower limb contracture is numb.Selecting Herba Epimedii is that temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.
The specific embodiment
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
10-20 gram of Cortex Cinnamomi 10-20 gram of Rhizoma Ligustici 10-20 Ke pig Xian
Radix Clematidis 10-20 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram of Caulis et Folium chloranthi serrati 10-20 gram
Radix Litseae pungentis 10-20 gram of Fructus litseae rubescentis 5-15 gram of Folium Artemisiae Argyi 5-15 gram
Bombyx Batryticatus 5-15 gram of Fructus Cnidii 5-15 gram of Fructus Psoraleae 5-15 gram
Radix Linderae 5-15 gram of Caulis Piperis Kadsurae 5-15 gram of Rhizoma Et Radix Notopterygii 5-15 gram
Radix Curcumae 15-25 gram of Fructus Evodiae 15-25 gram of Oletum Trogopterori 15-25 gram
Radix Morindae Officinalis 15-25 gram of Radix Dipsaci 15-25 gram of Rhizoma Corydalis 15-25 gram
Radix Achyranthis Bidentatae 15-25 gram of Rhizoma Atractylodis 15-25 gram of Radix Paeoniae Rubra 15-25 gram
Radix Gentianae Macrophyllae 10-20 gram of Semen Litchi 10-20 gram of Caulis Trachelospermi 10-20 gram
Rhizoma Homalomenae 10-20 gram of Herba Epimedii 10-20 gram
Preferable amount is
15 grams of 15 grams of Cortex Cinnamomis of Rhizoma Ligustici 15 Ke pig Xian
15 grams of 15 grams of Caulis et Folium chloranthi serratis of 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) of Radix Clematidis
10 grams of 10 grams of Folium Artemisiae Argyis of 15 grams of Fructus litseae rubescentis of Radix Litseae pungentis
10 grams of 10 grams of Fructus Psoraleaes of 10 grams of Fructus Cnidiis of Bombyx Batryticatus
10 grams of 10 grams of Rhizoma Et Radix Notopterygiis of 10 grams of Caulis Piperis Kadsuraes of the Radix Linderae
20 grams of 20 grams of Oletum Trogopteroris of 20 grams of Fructus Evodiaes of Radix Curcumae
20 grams of 20 grams of Rhizoma Corydalis of 20 grams of Radix Dipsacis of Radix Morindae Officinalis
20 grams of 20 grams of Radix Paeoniae Rubra of 20 grams of Rhizoma Atractylodis of Radix Achyranthis Bidentatae
15 grams of 15 grams of Caulis Trachelospermis of 15 grams of Semen Litchis of Radix Gentianae Macrophyllae
15 grams of 15 grams of Herba Epimedii of Rhizoma Homalomenae
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Rhizoma Ligustici: get crude drug, remove impurity, big or small stepping, wash quickly is clean, runs through, and section, dries;
2,, Herba Siegesbeckiae: choose decontamination, remove undesirable root and old stalk, first tremble inferior lobe and separately put, will obstruct cleanly, be soaked in water, pull out, run through rear section, dry, then with leaf and even;
3, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, by warm water, infiltrating a moment, section, dries;
4, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dries;
5, Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, dry in the air even to inside and outside humidity, section, dry;
6, Caulis et Folium chloranthi serrati: spring, summer gather, and choose decontamination, dry;
7, Radix Litseae pungentis: the 8-10 month excavates, cleans, and section, dries;
8, Fructus litseae rubescentis: the 8-9 month plucks, and chooses decontamination, dries;
9, Folium Artemisiae Argyi: choose decontamination, destemming, sieve dedust bits;
10, Bombyx Batryticatus: get crude drug, remove residual silk, impurity;
11, Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;
12, Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
13, the Radix Linderae: choose decontamination, size bar separately, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, sieve dedust bits;
14, Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, takes out and puts profit 16-24 hour in square-bottomed bamboo basket, and section, dries;
15, Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dries;
16, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
17, Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;
18, Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
19, Radix Morindae Officinalis: choose decontamination, after soaking, pump while hot core with hot water, cutting, dries;
20, Radix Dipsaci: clean silt, remove retained root head, run through rear section and dry, sieve anti-dandruff;
21, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
22, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
23, Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
24, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
25, Radix Gentianae Macrophyllae: choose decontamination, except removing LU, slightly soak, run through section, dry;
26, Semen Litchi: get crude drug, remove impurity, the used time smashs to pieces;
27, Caulis Trachelospermi: water washes away earth, chooses clean impurity, slightly soaks, and runs through, and cuts off, and dries;
28, Rhizoma Homalomenae: remove impurity, clean, run through, shave, dry, sieve removes chip;
29, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip.
Two, preparation
1, Rhizoma Ligustici, Herba Siegesbeckiae, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, the Herba Epimedii medicine of described weight are decocted with water twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 15 minutes, use again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time.
2, will filter for the first time rear medicinal residues and add 4 times of amounts of water, and decoct boiling, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time.
3, twice decoction liquor mixed, be divided into 6 doses and take.
Medicine of the present invention has promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness, and blood relaxing muscles and tendons, and the effect of dispersing cold for relieving pain, treatment rheumatic arthritis instant effect, short treating period, do not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 230 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation: rheumatic arthritis is a kind of performance of rheumatic fever.Rheumatic fever is that onset of disease has the infection medical histories such as erysipelas often by the whole body allergic disease due to the infection of A group beta hemolytic streptococcus.Rheumatic fever onset is anxious, and is more common in teenager.Rheumatic arthritis can be invaded heart, causes rheumatic heart disease, and has the performances such as heating, subcutaneous nodule and erythra.Rheumatic arthritis has two features: the one, and joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change is usually the large joints of lower limb such as knee joint, hip, ankle, is secondly shoulder, elbow, carpal joint, and brothers' little joint is rare; The 2nd, pain migration is indefinite, and a period of time is this joint outbreak, and a period of time is that joint is uncomfortable, and blood chemical examination erythrocyte sedimentation rate is accelerated, and anti-" 0 " titre raises, rheumatoid factor negative.Some patients can leave over heart change.Arthralgia is the modal symptom of rheumatism, and pain all likely occurs in whole body joint, but the pain of limbs and metastomium and may cause internal organs and neural pathological changes.Muscle also there will be pain symptom, but also may occur myasthenia, creatase rising, muscle-derived infringement etc., as systemic lupus erythematosus (sle), mixed connective tissue disease, dermatomyositis etc.Rheumatism there will be irregular fever phenomenon before occurring, there will not be the phenomenon of shivering, invalid with antibiotic therapy, also there will be erythrocyte sedimentation rate fast, as systemic lupus erythematosus (sle), acute neutrophilia heat generation skin disease, be grown up this Supreme Being's that disease, panniculitis etc. all can generate heat for onset symptoms simultaneously.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 5 courses for the treatment of.
4, efficacy assessment standard
Effective: rheumatic arthritis is eliminated, observe after half a year without recurrence;
Take a turn for the better: rheumatic arthritis symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy rheumatic arthritis patient of the present invention 170 examples, effective 222 examples of result, obvious effective rate is 96.52%, 5 examples that take a turn for the better, and improvement rate is 2.17%, invalid 3 examples, total effective rate is 98.69%.
Claims (3)
1. a medicine for the treatment of rheumatic arthritis, is characterized in that: it is to be made by the crude drug in following weight range:
10-20 gram of Cortex Cinnamomi 10-20 gram of Rhizoma Ligustici 10-20 Ke pig Xian
Radix Clematidis 10-20 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram of Caulis et Folium chloranthi serrati 10-20 gram
Radix Litseae pungentis 10-20 gram of Fructus litseae rubescentis 5-15 gram of Folium Artemisiae Argyi 5-15 gram
Bombyx Batryticatus 5-15 gram of Fructus Cnidii 5-15 gram of Fructus Psoraleae 5-15 gram
Radix Linderae 5-15 gram of Caulis Piperis Kadsurae 5-15 gram of Rhizoma Et Radix Notopterygii 5-15 gram
Radix Curcumae 15-25 gram of Fructus Evodiae 15-25 gram of Oletum Trogopterori 15-25 gram
Radix Morindae Officinalis 15-25 gram of Radix Dipsaci 15-25 gram of Rhizoma Corydalis 15-25 gram
Radix Achyranthis Bidentatae 15-25 gram of Rhizoma Atractylodis 15-25 gram of Radix Paeoniae Rubra 15-25 gram
Radix Gentianae Macrophyllae 10-20 gram of Semen Litchi 10-20 gram of Caulis Trachelospermi 10-20 gram
Rhizoma Homalomenae 10-20 gram of Herba Epimedii 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
15 grams of 15 grams of Cortex Cinnamomis of Rhizoma Ligustici 15 Ke pig Xian
15 grams of 15 grams of Caulis et Folium chloranthi serratis of 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) of Radix Clematidis
10 grams of 10 grams of Folium Artemisiae Argyis of 15 grams of Fructus litseae rubescentis of Radix Litseae pungentis
10 grams of 10 grams of Fructus Psoraleaes of 10 grams of Fructus Cnidiis of Bombyx Batryticatus
10 grams of 10 grams of Rhizoma Et Radix Notopterygiis of 10 grams of Caulis Piperis Kadsuraes of the Radix Linderae
20 grams of 20 grams of Oletum Trogopteroris of 20 grams of Fructus Evodiaes of Radix Curcumae
20 grams of 20 grams of Rhizoma Corydalis of 20 grams of Radix Dipsacis of Radix Morindae Officinalis
20 grams of 20 grams of Radix Paeoniae Rubra of 20 grams of Rhizoma Atractylodis of Radix Achyranthis Bidentatae
15 grams of 15 grams of Caulis Trachelospermis of 15 grams of Semen Litchis of Radix Gentianae Macrophyllae
15 grams of 15 grams of Herba Epimedii of Rhizoma Homalomenae.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Rhizoma Ligustici: get crude drug, remove impurity, big or small stepping, wash quickly is clean, runs through, and section, dries;
(2) Herba Siegesbeckiae: choose decontamination, remove undesirable root and old stalk, first tremble inferior lobe and separately put, will obstruct cleanly, be soaked in water, pull out, run through rear section, dry, then with leaf and even;
(3) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, by warm water, infiltrating a moment, section, dries;
(4) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dries;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, dry in the air even to inside and outside humidity, section, dry;
(6) Caulis et Folium chloranthi serrati: spring, summer gather, and choose decontamination, dry;
(7) Radix Litseae pungentis: the 8-10 month excavates, cleans, and section, dries;
(8) Fructus litseae rubescentis: the 8-9 month plucks, and chooses decontamination, dries;
(9) Folium Artemisiae Argyi: choose decontamination, destemming, sieve dedust bits;
(10) Bombyx Batryticatus: get crude drug, remove residual silk, impurity;
(11) Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;
(12) Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
(13) Radix Linderae: choose decontamination, size bar separately, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, sieve dedust bits;
(14) Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, takes out and puts profit 16-24 hour in square-bottomed bamboo basket, and section, dries;
(15) Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dries;
(16) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
(17) Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;
(18) Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
(19) Radix Morindae Officinalis: choose decontamination, after soaking, pump while hot core with hot water, cutting, dries;
(20) Radix Dipsaci: clean silt, remove retained root head, run through rear section and dry, sieve anti-dandruff;
(21) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(22) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(23) Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
(24) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
(25) Radix Gentianae Macrophyllae: choose decontamination, except removing LU, slightly soak, run through section, dry;
(26) Semen Litchi: get crude drug, remove impurity, the used time smashs to pieces;
(27) Caulis Trachelospermi: water washes away earth, chooses clean impurity, slightly soaks, and runs through, and cuts off, and dries;
(28) Rhizoma Homalomenae: remove impurity, clean, run through, shave, dry, sieve removes chip;
(29) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
(2) preparation
(1) Rhizoma Ligustici, Herba Siegesbeckiae, Cortex Cinnamomi, Radix Clematidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis et Folium chloranthi serrati, Radix Litseae pungentis, Fructus litseae rubescentis, Folium Artemisiae Argyi, Bombyx Batryticatus, Fructus Cnidii, Fructus Psoraleae, the Radix Linderae, Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Curcumae, Fructus Evodiae, Oletum Trogopterori, Radix Morindae Officinalis, Radix Dipsaci, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Radix Paeoniae Rubra, Radix Gentianae Macrophyllae, Semen Litchi, Caulis Trachelospermi, Rhizoma Homalomenae, the Herba Epimedii medicine of described weight are decocted with water twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 15 minutes, use again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time;
(2) will filter for the first time rear medicinal residues and add 4 times of amounts of water, and decoct boiling, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time;
(3) twice decoction liquor mixed, be divided into 6 doses and take.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310582055.3A CN103638448B (en) | 2013-11-20 | 2013-11-20 | Medicine used for treating rheumatoid arthritis, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310582055.3A CN103638448B (en) | 2013-11-20 | 2013-11-20 | Medicine used for treating rheumatoid arthritis, and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106306113A (en) * | 2015-03-26 | 2017-01-11 | 周森荣 | Camphor tree fruit vegetable oil |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN1446558A (en) * | 2002-05-26 | 2003-10-08 | 吴立让 | Blaster for treating rheumatoid arthritis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN1446558A (en) * | 2002-05-26 | 2003-10-08 | 吴立让 | Blaster for treating rheumatoid arthritis |
Non-Patent Citations (1)
| Title |
|---|
| 刘淑清: "中医药治疗类风湿关节炎概况", 《辽宁中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106306113A (en) * | 2015-03-26 | 2017-01-11 | 周森荣 | Camphor tree fruit vegetable oil |
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| CN103638448B (en) | 2015-06-03 |
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