CN101417087B - Medicine for treating gynecology postpartum disease and preparation method thereof - Google Patents

Medicine for treating gynecology postpartum disease and preparation method thereof Download PDF

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CN101417087B
CN101417087B CN2008101812769A CN200810181276A CN101417087B CN 101417087 B CN101417087 B CN 101417087B CN 2008101812769 A CN2008101812769 A CN 2008101812769A CN 200810181276 A CN200810181276 A CN 200810181276A CN 101417087 B CN101417087 B CN 101417087B
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王督
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王督
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Abstract

The invention discloses a medicine used for treating gynaecological postpartum diseases, which is prepared with rhizome gastrodiae, angelica, motherwort herb, rhizoma ligustici wallichii, rehmanniae vaporate and safflower by a certain weight ratio and the medicine can be prepared into any conventional internal-used preparation. The medicine has the functions of clearing heat to excrete water, enriching the blood to regulate menstruation and removing blood stasis to relieve pain; the medicine has quick curative effect and a high cure rate when being used for treating various gynaecological postpartum diseases.

Description

A kind of medicine for the treatment of gynaecologic postpartum disease and preparation method thereof
Technical field:
The present invention relates to a kind of medicine for the treatment of gynaecologic postpartum disease and preparation method thereof, belong to the field of Chinese medicines.
Background technology:
Puerperal blood faints, placenta retention, puerperal tripe abdomen pain around the clock, puerperal edema, postnatal borborygmus and driping leukorrhea, puerperal hundred, various disease conditions such as bone pain, postnatal pulseless of limbs and retention of dead fetus was a gynaecologic postpartum disease.The puerpera is through being ten months' pregnant to production, and physical demands is bigger, and is drained, as untimely treatment, will jeopardize life.At present the treatment gynaecologic postpartum disease is many based on western medical treatment, and the western medicine gynaecopathia can only be carried out part and alleviated or symptomatic treatment, stop blooding, relieve the pain, antiinflammatory, prevention infection, but the side effect of Western medicine is big, the course of treatment length still can not be satisfactory.
Summary of the invention:
Therefore, there is great demand in people's Chinese medicine preparation that curative effect is treated gynaecologic postpartum disease preferably.Up to now, also do not find the relevant report of relevant pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has worked out the oral medicinal herb medicine of the treatment gynaecologic postpartum disease with better curative effect finally on the basis of secret prescription handed down in the family from generation to generation, thereby has finished the present invention.
Purpose of the present invention just provides a kind of Chinese medicine composition of more effectively treating gynaecologic postpartum disease, and another object of the present invention has just provided the preparation method of this Chinese medicine composition.
Medicament selection Rhizoma Gastrodiae of the present invention, Radix Angelicae Sinensis, Herba Leonuri, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Flos Carthami, China ink make up.With these drug regimens, make each efficacy of drugs produce synergism, thereby can effectively treat gynecological's various diseases in puerperal.Wherein select for use Rhizoma Gastrodiae to be because the Rhizoma Gastrodiae nature and flavor are sweet, flat, go into Liver Channel.Endogenous wind stopping is arranged, the function of arresting convulsion.Control dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom.Selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel because of the sweet suffering of its nature and flavor.Benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation.Control menoxenia, amenorrhea stomachache, the lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; The dryness of the intestine dyschezia is heavy after the bloody dysentery; Ulcer sores, injury from falling down.Select for use Herba Leonuri to be because its nature and flavor are arduous, pericardium, Liver Channel are gone in cold.Invigorate blood circulation blood stasis dispelling, regulating menstruation, the function of the water that disappears.Control menoxenia, the vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria is rushed down blood, carbuncle, skin infection.Selecting Rhizoma Chuanxiong for use is that temperature is gone into liver, gallbladder meridian because of its nature and flavor suffering.Activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain.Controlling air-cooled headache changes dizzy, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Radix Rehmanniae Preparata for use, the different name Radix Rehmanniae Preparata is that tepor is gone into liver, kidney channel because its nature and flavor are sweet.YIN nourishing is arranged, the function of enriching blood.Control deficiency of YIN insufficiency of blood, the waist knee flaccidity, the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Selecting Flos Carthami for use is that temperature is gone into the heart, Liver Channel because of its nature and flavor suffering.Promoting blood circulation to restore menstrual flow is arranged, blood stasis removing analgesic function.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.Select China ink for use, different name coal, Chen Xuan, profound perfume (or spice), black beautiful piece are pine soot and go into the China ink that glue juice, spice etc. are processed into, and it is good that levigation is used as medicine with Chen Jiuzhe.Nature and flavor are hot flat, and the GUIXIN Liver Channel has hemostasis, repercussive function.Control haematemesis, epistaxis, metrorrhagia and metrostaxis, dysentery, carbuncle carbuncle on the back.
In order to reach the curative effect of better healing puerperal blood faints, medicine of the present invention also makes up with Flos Carthami, Cortex ulmi pumilae, urine of baby boys, and this is that temperature is gone into the heart, Liver Channel because of Flos Carthami nature and flavor suffering.Promoting blood circulation to restore menstrual flow is arranged, blood stasis removing analgesic function.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.The Cortex ulmi pumilae nature and flavor are sweet flat, return brothers' sun, meridian of Hand-YANG MING, and diuretic, treating stranguria, detumescence can be controlled urinary obstruction, stranguria with turbid discharge, edema, carbuncle carbuncle on the back, erysipelas scabies.Urine of baby boys with the urine of baby boys below 10 years old urine of baby boys, its salty in the mouth, cold in nature, can nourishing YIN to lower pathogenic fire, cool the blood dissipate blood stasis, and have treatment deficiency of YIN fire to rise the effect of the cough, haematemesis, epistaxis and the puerperal blood faints that cause.But urine of baby boys both can oral also external, external curing traumatic injury, conjunctival congestion and swelling pain, and curative effect is fabulous, orally taken for curing cough, haematemesis, epistaxis etc.In addition, the urokinase that extracts from urine has the effect of dissolving the heart, lung, optical fundus and intracranial thrombosis, and the treatment phlebothrombosis is had significant curative effect.Simultaneously, also be a kind of good medicine of treatment coronary heart disease.Chorionic-gonadotropin hormone extracts from anemia of pregnant woman urine, is used for the treatment of metrorrhagia, secondary amenorrhea, disease such as sterile clinically.
In order to reach the better curative effect of better healing placenta retention, medicine of the present invention also makes up with Pulvis Fumi Carbonisatus, the Radix Paeoniae Alba, and this is that temperature is gone into liver, lung, stomach warp because of Pulvis Fumi Carbonisatus nature and flavor suffering.Hemostasis is arranged, the function of removing food stagnancy.Control epistaxis, have blood in stool, metrorrhagia, leukorrhagia, dysentery, food stagnation, all skin ulcers of throat dispute.The Radix Paeoniae Alba has another name called Radix Paeoniae Alba, the nature and flavor picric acid, and liver, spleen channel are gone in cold.Nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
In order to reach the around-the-clock better curative effect of treatment tripe abdomen pain in puerperal, medicine of the present invention also makes up with Niu Xi, rhizoma sparganic, Flos Carthami, Lignum Sappan, and this is because of Niu Xi, the different name Radix Achyranthis Bidentatae, and the acid of nature and flavor sweetness and bitterness, flat, go into liver, kidney channel.Have to give birth to and use dissipating blood stasis blood, the function of subduing inflammation.Control gonorrhea, hematuria, amenorrhea, lump in the abdomen, difficult labour, corset is not following, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury.Rhizoma sparganic nature and flavor toil, flat, go into liver, spleen channel.Removing blood stasis is arranged, circulation of qi promoting, removing food stagnancy, analgesic function.Control lump in the abdomen, QI and blood is coagulated band, trusted subordinate's pain, and the side of body expands painful down, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer is swollen hard.Flos Carthami nature and flavor suffering, temperature is gone into the heart, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, blood stasis removing analgesic function.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.Lignum Sappan property sweet-salty, flat, go into the heart, Liver Channel.Promoting the circulation of blood is arranged, removing blood stasis with potent drugs, detumescence, pain relieving.Control married woman's vim and vigour cardiac and abdominal pain, amenorrhea, postnatal blood stasis distending pain dyspnea with rapid respiration, dysentery, tetanus, carbuncle is pounced on and is decreased the stasis of blood and stagnate and have a pain.
In order to reach the best curative effect of treatment puerperal edema, medicine of the present invention also makes up with Herba Dianthi, Cortex ulmi pumilae, and this is because Herba Dianthi nature and flavor hardship is cold, goes into the heart, kidney, small intestinal, urinary bladder channel.Clearing away heat and promoting diuresis is arranged, the function that removing blood stasis stimulates the menstrual flow.Control urinary obstruction, gonorrhea, edema, amenorrhea, carbuncle, conjunctival congestion is hidden from view, the contamination sore.The Cortex ulmi pumilae nature and flavor are sweet flat, return brothers' sun, meridian of Hand-YANG MING, and diuretic, treating stranguria, detumescence can be controlled urinary obstruction, stranguria with turbid discharge, edema, carbuncle carbuncle on the back, erysipelas scabies.
In order to reach the better effect of treatment postnatal borborygmus and driping leukorrhea, medicine of the present invention also with the combination of juice of white turnip, GUTONGQIAN, this is because white turnip is the main vegetable of root vegetables, is fresh of Cruciferae Rhaphanus Radix Raphani, one, biennial book on Chinese herbal medicine.White turnip is a kind of common vegetable, eat raw prepared food all can, its slightly acid of distinguishing the flavor of.Modern study thinks that white turnip contains mustard oil, amylase and crude fibre, has facilitating digestion, appetite strengthening, the effect of accelerate gastrointestinal wriggling and relieving cough and resolving phlegm.Theory of Chinese medical science is also thought this product acrid-sweet flavor, and is cool in nature, goes into lung stomach warp, is the dietetic therapy good merchantable brand, squeezes the juice and is used as medicine, and can treat or the multiple disease of auxiliary treatment, and Compendium of Materia Medica is referred to as " the most favourable person in the vegetables ".GUTONGQIAN is copper coin that ancient times, bronze was made.
In order to reach the best curative effect of treatment bone pain in puerperal hundred, medicine of the present invention also makes up with yellow wine, copper bell, and this is because yellow wine is a kind of beverage that rice, wheat, broomcorn millet, Sorghum vulgare Pers. etc. and song lead to, nature and flavor sweetness and bitterness, Xin Wen is poisonous, GUIXIN liver, lung, stomach warp have promoting blood circulation, resisting cold gas, the function of row medicine gesture, treatment wind and cold splenalgia, muscle arteries and veins contraction is anxious, the thoracic obstruction, trusted subordinate's cold type of pain.The copper bell is a wineglass made of copper.
In order to reach the best curative effect of treatment postnatal pulseless of limbs, medicine of the present invention also makes up with Rhizoma Cimicifugae, and this is that lung, spleen, stomach warp are gone in cold because of the little hardship of the sweet suffering of Rhizoma Cimicifugae nature and flavor.Yang invigorating is arranged, deliver, rash, antidotal function.Control seasonal epidemic pathogens epidemic disease scrofula, the headache cold and heat, laryngalgia, aphtha, macule are not saturating; Sinking of QI of middle-JIAO, the chronic diarrhea chronic dysentery, proctoptosis, the women is collapsed, band, uterus tenesmus; Carbuncle sore tumefacting virus.
In order to reach the best curative effect of treatment retention of dead fetus, medicine of the present invention also with Cortex Cinnamomi or Herba Dianthi, Flos Carthami, when being grouped into, this is because Cortex Cinnamomi, the different name Cortex Cinnamomi, the property acrid-sweet flavor, heat is gone into kidney, spleen, urinary bladder channel.The complement sun is arranged, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, chills and pain of the waist and kness, the amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, cold under the last gesture.Herba Dianthi: the nature and flavor hardship, cold, go into the heart, kidney, small intestinal, urinary bladder channel.Clearing away heat and promoting diuresis is arranged, the function that removing blood stasis stimulates the menstrual flow.Control urinary obstruction, gonorrhea, edema, amenorrhea, carbuncle, conjunctival congestion is hidden from view, the contamination sore.Flos Carthami: the nature and flavor suffering, temperature is gone into the heart, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, blood stasis removing analgesic function.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.The sweet suffering of Radix Angelicae Sinensis nature and flavor, temperature is gone into the heart, liver, spleen channel.Benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation.It is uncomfortable to control the moon, amenorrhea stomachache, and the lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; The dryness of the intestine dyschezia is heavy after the bloody dysentery; Ulcer sores, injury from falling down.
In order to reach the best curative effect of treatment puerperal alternation of chill and fever, medicine of the present invention also makes up with vinegar, urine of baby boys, and this is that temperature is gone into liver, stomach warp because the vinegar nature and flavor are bitter.Dissipating blood stasis is arranged, hemostasis, detoxifcation, parasiticidal function.Bruise after managing property, the mass beside the umbilicus lump in the abdomen, jaundice, yellowish perspiration is spitted blood, epistaxis, the stool hematochezia, pudendal pruritus, the carbuncle skin ulcer is swollen.Urine of baby boys be urine of baby boys below 10 years old urine of baby boys, its salty in the mouth, cold in nature, can nourishing YIN to lower pathogenic fire, cool the blood dissipate blood stasis, and have treatment deficiency of YIN fire to rise the effect of the cough, haematemesis, epistaxis and the puerperal blood faints that cause.But urine of baby boys both can oral also external, external curing traumatic injury, conjunctival congestion and swelling pain, and curative effect is fabulous, orally taken for curing cough, haematemesis, epistaxis etc.In addition, the urokinase that extracts from urine has the effect of dissolving the heart, lung, optical fundus and intracranial thrombosis, and the treatment phlebothrombosis is had significant curative effect.Simultaneously, also be a kind of good medicine of treatment coronary heart disease.Chorionic-gonadotropin hormone extracts from anemia of pregnant woman urine, is used for the treatment of metrorrhagia, secondary amenorrhea, disease such as sterile clinically.
In order to reach treatment puerperal blood faints falling into a swoon, medicine of the present invention also makes up with Herba Schizonepetae, Niu Xi, Radix Cirsii Japonici, Herba Kalimeridis, rhizoma sparganic, Rhizoma Chuanxiong, Lignum Sappan, urine of baby boys, yellow wine, and this is that tepor goes into to return lung, Liver Channel because of Herba Schizonepetae nature and flavor suffering.The diffusing wind that induces sweat, rash, the skin ulcer that disappears, hemostasis.The liver spleen channel is returned in the sweet cold of Radix Cirsii Japonici nature and flavor, cooling blood for hemostasis, and blood stasis dispelling is controlled haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, enterodynia, carbuncle and ulcer toxic swelling, furuncle.Herba Kalimeridis is pungent in flavor and cool in property, is included into positive bright blood system warp, and removing heat from blood is arranged, clearing away heat-damp and promoting diuresis, and the antidotal function is controlled haematemesis, epistaxis, dysentery, skin ulcer is hindered hemorrhage, Malaria jaundice, edema, stranguria with turbid discharge, hemorrhoid, carbuncle, erysipelas, venom.Yellow wine a kind of beverage that to be rice, wheat, broomcorn millet, Sorghum vulgare Pers. etc. lead to song, nature and flavor sweetness and bitterness, Xin Wen is poisonous, and GUIXIN liver, lung, stomach warp have promoting blood circulation, resisting cold gas, the function of row medicine gesture, treatment wind and cold splenalgia, muscle arteries and veins contraction is anxious, the thoracic obstruction, trusted subordinate's cold type of pain.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has curative effect preferably in following weight range.
Rhizoma Gastrodiae 200-250 gram Radix Angelicae Sinensis 150-200 gram Herba Leonuris 600-700 grams
Rhizoma Chuanxiong 150-200 gram Radix Rehmanniaes Preparata 200-250 gram Flos Carthamis 150-200 grams
Ink powder 300-400 grams
The optimum amount of medicine of the present invention is: Rhizoma Gastrodiae 220 grams, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 grams, ink powder 350 grams, Cortex Cinnamomi 10 grams, Cortex ulmi pumilae 10 grams, urine of baby boys 10 grams, cattle sunset 10 restrain, rhizoma sparganic 10 grams, Lignum Sappan 10 grams, Herba Dianthi 10 grams, juice of white turnip 10 grams, yellow wine 10 grams, Rhizoma Cimicifugae 10 grams, vinegar 10 grams, Radix Cirsii Japonici 10 grams, Herba Kalimeridis 10 grams.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the oral preparations of any routine, for example these crude drug pulverize mix homogeneously can be made pill swallows, the snap fit capsule of also these crude drug pulverizes can being packed into, or crude drug is ground into fine powder adds adjuvant and make the granule compacting in flakes.
The medicine that the present invention treats gynaecologic postpartum disease is divided into principal agent and accessory drugs two big classes, and accessory drugs is divided into 10 little types from A to J again, is essential drug with the principal agent when taking, and adds accessory drugs according to different disease types again, to reach better therapeutic effect.
The preparation method of medicine of the present invention is as follows, and it comprises the following steps:
One, get the raw materials ready:
1, Rhizoma Gastrodiae: choose decontamination, big or small stepping converges to seventy percent saturating with water logging, pulls out, dries in the air slightly, and profit is even to inside and outside humidity again, and section is dried.
2, Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to internal and external temperature when suitable, and section is dried.
3, Herba Leonuri: choose decontamination, clean, run through, cutting is dried.
4, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening.
5, Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, get Radix Rehmanniae and add yellow wine 30%, mix and stir, go in the steaming device, steam to inside and outside black profit, taking-up is dried.
6, Flos Carthami: choose decontamination, remove stem and leaf, base of a fruit head, dry.
7, China ink: grind to form ink powder and be used as medicine.
8, Cortex Cinnamomi: choose decontamination, scrape off rough bark, the time spent smashes, or scrapes off rough bark, carves with the section of eliminating cold for resuscitation water infiltration, and section is dried.
9, Herba Dianthi: choose decontamination, remove undesirable root, clean, stewing profit, cutting is dried.
10, Pulvis Fumi Carbonisatus: the grey black with in chimney or the chimney, scrape gently, sieve decontamination with dusting cover.
11, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying.
12, Cortex ulmi pumilae: spring or 8-9 cut off old branch between the month, strip endothelium immediately and dry.
13, urine of baby boys: get fresh urine of baby boys.
14, Niu Xi: choose clean impurity, clean, moisten softly, go reed, cutting is dried.
15, rhizoma sparganic: choose clean impurity, be soaked in water, pull out and run through, section is dried.
16, Lignum Sappan: remove crust and sapwood, dry, smooth file, hard ramming is mixed slice prunus mume (sieb.) sieb.et zucc. branch and is steamed, and from the sixth of the twelve Earthly Branches to the Shen, goes out, and dries in the shade.
17, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries.
18, Radix Cirsii Japonici: choose clean impurity, clear water is cleaned, and runs through, and cutting is dried.
19, Herba Kalimeridis: Xia Qiu gathers, and dries.
20, yellow wine: take by weighing according to quantity.
21, vinegar: take by weighing according to quantity.
22, Rhizoma Cimicifugae: choose clean impurity, slightly bubble is cleaned, and pulls out, runs through, and section is dried.
23, juice of white turnip, with fresh white Radix Raphani flush away earth, stripping and slicing is squeezed the juice.
24, GUTONGQIAN: extract according to quantity.
25, copper bell: clean standby.
Two, the preparation of principal agent
1, the preparation of pill:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into superfine powder.
B, the superfine powder of pulverizing is added ink powder 350 grams stir and add the pill that water is made the soybean grain size, every ball 0.10 gram.
2, the preparation of capsule:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into fine powder.
B, the fine powder of pulverizing is added ink powder 350 grams, stir, oven dry incapsulates.
3, the preparation of tablet:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into fine powder.
B, the fine powder of pulverizing is added ink powder 350 grams, stirring adds adjuvant and makes the granule compacting in flakes.
Three, the preparation of accessory drugs
The agent of A type: take by weighing Cortex ulmi pumilae 10 grams, Flos Carthami 10 grams, urine of baby boys 10 grams add water and decocted 20 minutes for 300 milliliters when taking.
The Type B agent: get Pulvis Fumi Carbonisatus 10 grams, the Radix Paeoniae Alba 10 grams add water and decocted 20 minutes for 300 milliliters when taking.
The agent of C type: get title cattle sunset 10 gram, rhizoma sparganic 10 grams, Flos Carthami 10 grams, Lignum Sappan 10 grams add 300 milliliters of decoctions of water 20 minutes when taking.
The agent of D type: take by weighing Herba Dianthi 10 grams, Cortex ulmi pumilae 10 grams add water and decocted 20 minutes for 300 milliliters when taking.
E dosage form: squeeze juice of white turnip 10 grams, get 7 pieces of GUTONGQIAN again, add water when taking and decocted 20 minutes for 250 milliliters.
The F dosage form: take by weighing yellow wine 100 gram, when taking with the copper bell yellow wine of heating.
G dosage form: get title Rhizoma Cimicifugae 10 grams, add water and decocted 15 minutes for 250 milliliters.
The H dosage form: take by weighing Cortex Cinnamomi 10 grams, Flos Carthami 10 grams, Radix Angelicae Sinensis 10 grams add water and decocted 20 minutes for 300 milliliters.
The I dosage form: take by weighing vinegar 10 grams, urine of baby boys 10 grams add water and decocted 15 minutes for 250 milliliters.
J dosage form: take by weighing Herba Schizonepetae, Niu Xi, Radix Cirsii Japonici, Herba Kalimeridis, rhizoma sparganic, Rhizoma Chuanxiong, Flos Carthami, Lignum Sappan, urine of baby boys, each 10 gram of yellow wine, add water and decocted 20 minutes for 300 milliliters.
Medicine of the present invention has clearing away heat and promoting diuresis, tonifying blood and regulating menstruation, blood stasis removing analgesic function, is used for the treatment of gynecological's all kinds of diseases in puerperal.
The specific embodiment:
Below further set forth the beneficial effect of medicine of the present invention by testing example, these test the routine viewing test that comprises animal experiment and clinical treatment effect.
The animal toxicity test report of [test example 1] medicine of the present invention
1, animal is selected
Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, every group 10 gram, wherein one group is the test group that normal amount is taken medicine, the matched group that another group is taken medicine for super quantity.
2, test method: adopt administration by gavage, test group is irritated every 0.06 gram of this medicament of stomach, serve on 7 days every day 2 times, and every of matched group is irritated this medicament of stomach 0.12 gram, serve on 7 days every day 2 times, observes medication reaction every day.
3, result of the test: 20 of test group and matched groups, after rabbit is taken medicine, physical agility, appetite is normal, and poisoning symptom and untoward reaction take place in none example, prove that medicine of the present invention has no side effect.
Clinical and the observation of [test example 2] Drug therapy gynaecologic postpartum disease of the present invention
1, physical data:
Treatment out-patient 679 examples, 20-35 years old ages wherein, 486 examples; 35-45 years old, 190 examples; 3 examples more than 45 years old
2, diagnostic criteria
1. puerperal blood faints: the patient is the body constitution collapse in 3-5 days puerperal, has a dizzy spell, and the physcial vigours of young people, pupil is flower earlier.
2. placenta retention: give birth to female blood because of tire and flow in the bag not down, so that pour in the abdomen, extremity are cold faints, and this is a danger disease.
3. puerperal tripe abdomen pain, around the clock: puerperal patient's arteries and veins blood not to the greatest extent, stream does not stagnate between the intestinal tripe, so that causes pain.
4. puerperal edema: blood vessels flowed in the vital organs of the human body and changeed in extremity puerperal, and stream stagnates not to return and causes the extremity edema.
5. postnatal borborygmus and driping leukorrhea: puerperal the patient's thing or unboiled water of raw and cold stick-slip of before full moon, eating and drinking, flow into large intestine, the time do borborygmus, it is unclear to let out dysentery.
6. puerperal hundred bone pain, patient's superficial heat of falling ill puerperal, hundred bones pain all from head to foot, waist can not change, brothers can not take action.
7. postnatal pulseless of limbs: it is dirty that patient's deteriorated blood flows into internal organs, looses and extremity, so blood vessels are low and deep, brothers are ice-cold.
8. retention of dead fetus, children's's tire is shaped, and the dirty heat of parent internal organs is dry, and children's but is heated, and fetus extremely occupies in the abdomen, puerpera's cold extremities, fingernail green grass or young crops, mouthful saliva.
9. puerperal alternation of chill and fever: puerperal asthenia, the vim and vigour migration is uncertain, injures spleen lung serious symptom, so xerostomia tongue hardship, cold and hot sensation appearing in turn.
10. puerperal blood faints, falling into a swoon: puerpera's body constitution extremely feeble, mental confusion is tired waste, vim and vigour upper punch, falling into a swoon syncope.
3, Therapeutic Method:
1. puerperal blood faints: obey principal agent 10 balls oral 3 times of every day at every turn, take with A type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment;
2. placenta retention: obey principal agent 10 balls oral 3 times of every day at every turn, take with Type B agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
3. puerperal edema around the clock: obey principal agent 10 balls oral 3 times of every day at every turn, obey principal agent 10 balls at every turn, take with C type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
4. puerperal edema: obey principal agent 10 balls oral 3 times of every day at every turn, take with D type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
5. postnatal borborygmus and driping leukorrhea: obey principal agent 10 balls oral 3 times of every day at every turn, take with E type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
6. puerperal hundred bone pain: obey principal agent 10 balls oral 3 times of every day at every turn, take with F type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
7. postnatal pulseless of limbs: obey principal agent 10 balls oral 3 times of every day at every turn, take with G type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
8. retention of dead fetus: obey principal agent 10 balls oral 3 times of every day at every turn, take with H type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
9. puerperal alternation of chill and fever: obey principal agent 10 balls oral 3 times of every day at every turn, take with I type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
10. puerperal blood faints falling into a swoon: obey principal agent 10 balls oral 3 times of every day at every turn, take with J type agent accessory drugs, 7 days is a course of treatment, serve on 1-2 courses of treatment.
4, imitate the treatment evaluation criteria
Produce effects: various gynaecopathias are after treatment, and physical rehabilitation is as usual, recover orthobiosis.
Take a turn for the better: patient's focus is eliminated, and health is recovered substantially.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In 2 course of therapy, with Drug therapy puerperal blood faints patient 162 examples of the present invention, produce effects 150 examples, 10 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 92.59%, and improvement rate is 6.17%, and aggregate efficiency is 98.77%; Treatment placenta retention patient 23 examples, produce effects 19 examples, 3 examples that take a turn for the better, invalid 1 example, obvious effective rate is 82.60%, and improvement rate is 13.04%, and total effective rate is 95.65%.Treatment tripe abdomen pain in puerperal is patient's 147 examples around the clock, produce effects 132 examples, and 12 examples that take a turn for the better, invalid 3 examples, obvious effective rate is 89.79%, and improvement rate is 8.16%, and total effective rate is 97.96%; Treatment puerperal edema patient 86 examples, produce effects 83 examples, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is that 96.51% improvement rate is 2.32%, total effective rate is 98.84%; Treatment postnatal borborygmus and driping leukorrhea patient 49 examples, produce effects 47 examples, 2 examples that take a turn for the better, total effective rate is 100%; Treatment hundred bone pain patients, 47 examples in puerperal, produce effects 44 examples, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is 93.61%, and improvement rate is 4.26%, and total effective rate is 97.87%; Treatment postnatal pulseless of limbs patient 58 examples, produce effects 55 examples, 1 example that takes a turn for the better, invalid 2 examples, obvious effective rate is 94.82%, and improvement rate is 1.72%, and total effective rate is 96.55%; Treatment retention of dead fetus patient 24 examples, produce effects 21 examples, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is 87.50%, and improvement rate is 8.33%, and total effective rate is 95.83%; Treatment puerperal alternation of chill and fever patient 55 examples, produce effects 50 examples, 5 examples that take a turn for the better, total effective rate is 100%; Treatment puerperal blood faints falling into a swoon patient 28 examples, produce effects 26 examples, 1 example that takes a turn for the better, invalid 1 example, obvious effective rate is 92.85%, improvement rate 3.57%, total effective rate are 96.43%.

Claims (1)

1. preparation method for the treatment of the gynaecologic postpartum disease medicine, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready:
(1) Rhizoma Gastrodiae: choose decontamination, big or small stepping converges to seventy percent saturating with water logging, pulls out, dries in the air slightly, and profit is even to inside and outside humidity again, and section is dried;
(2) Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to internal and external temperature when suitable, and section is dried;
(3) Herba Leonuri: choose decontamination, clean, run through, cutting is dried;
(4) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(5) Radix Rehmanniae Preparata: get Radix Rehmanniae and add yellow wine 30%, mix and stir, go in the steaming device, steam to inside and outside black profit, taking-up is dried;
(6) Flos Carthami: choose decontamination, remove stem and leaf, base of a fruit head, dry;
(7) China ink: grind to form ink powder and be used as medicine;
(8) Cortex Cinnamomi: choose decontamination, scrape off rough bark, the time spent smashes, or scrapes off rough bark, carves with the section of eliminating cold for resuscitation water infiltration, and section is dried;
(9) Herba Dianthi: choose decontamination, remove undesirable root, clean, stewing profit, cutting is dried;
(10) Pulvis Fumi Carbonisatus: the grey black with in chimney or the chimney, scrape gently, sieve decontamination with dusting cover;
(11) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(12) Cortex ulmi pumilae: spring or 8-9 cut off old branch between the month, strip endothelium immediately and dry;
(13) urine of baby boys: get fresh urine of baby boys;
(14) Radix Achyranthis Bidentatae: choose clean impurity, clean, moisten softly, go reed, cutting is dried;
(15) rhizoma sparganic: choose clean impurity, be soaked in water, pull out and run through, section is dried;
(16) Lignum Sappan: remove crust and sapwood, dry, smooth file, hard ramming is mixed slice prunus mume (sieb.) sieb.et zucc. branch and is steamed, and from the sixth of the twelve Earthly Branches to the Shen, goes out, and dries in the shade;
(17) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;
(18) Radix Cirsii Japonici: choose clean impurity, clear water is cleaned, and runs through, and cutting is dried;
(19) Herba Kalimeridis: Xia Qiu gathers, and dries;
(20) yellow wine: take by weighing according to quantity;
(21) vinegar: take by weighing according to quantity;
(22) Rhizoma Cimicifugae: choose clean impurity, slightly bubble is cleaned, and pulls out, runs through, and section is dried;
(23) juice of white turnip: with fresh white Radix Raphani flush away earth, stripping and slicing is squeezed the juice;
(24) GUTONGQIAN: extract according to quantity;
(25) copper bell: clean standby;
(2) preparation of principal agent
(1) preparation of pill:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into superfine powder;
B, the superfine powder of pulverizing is added ink powder 350 grams stir and add the pill that water is made the soybean grain size, every ball 0.10 gram;
(2) preparation of capsule:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into fine powder;
B, the fine powder of pulverizing is added ink powder 350 grams, stir, oven dry incapsulates;
(3) preparation of tablet:
A, with Rhizoma Gastrodiae 220 gram, Radix Angelicae Sinensis 180 grams, Herba Leonuri 650 grams, Rhizoma Chuanxiong 180 grams, Radix Rehmanniae Preparata 220 grams, Flos Carthami 180 gram mixed powders are broken into fine powder;
B, the fine powder of pulverizing is added ink powder 350 grams, stirring adds adjuvant and makes the granule compacting in flakes;
(3) preparation of accessory drugs
The agent of A type: take by weighing Cortex ulmi pumilae 10 grams, Flos Carthami 10 grams, urine of baby boys 10 grams add water and decocted 20 minutes for 300 milliliters when taking;
The Type B agent: get Pulvis Fumi Carbonisatus 10 grams, the Radix Paeoniae Alba 10 grams add water and decocted 20 minutes for 300 milliliters when taking;
The agent of C type: take by weighing Radix Achyranthis Bidentatae 10 grams, rhizoma sparganic 10 grams, Flos Carthami 10 grams, Lignum Sappan 10 grams add water and decocted 20 minutes for 300 milliliters when taking;
The agent of D type: take by weighing Herba Dianthi 10 grams, Cortex ulmi pumilae 10 grams add water and decocted 20 minutes for 300 milliliters when taking;
E type agent: squeeze juice of white turnip 10 grams, get 7 pieces of GUTONGQIAN again, add water when taking and decocted 20 minutes for 250 milliliters;
The agent of F type: take by weighing yellow wine 100 gram, when taking with the copper bell yellow wine of heating;
G type agent: take by weighing Rhizoma Cimicifugae 10 grams, add water and decocted 15 minutes for 250 milliliters;
The agent of H type: take by weighing Cortex Cinnamomi 10 grams, Flos Carthami 10 grams, Radix Angelicae Sinensis 10 grams add water and decocted 20 minutes for 300 milliliters;
The agent of I type: take by weighing vinegar 10 grams, urine of baby boys 10 grams add water and decocted 15 minutes for 250 milliliters;
J type agent: take by weighing Herba Schizonepetae, Radix Achyranthis Bidentatae, Radix Cirsii Japonici, Herba Kalimeridis, rhizoma sparganic, Rhizoma Chuanxiong, Flos Carthami, Lignum Sappan, urine of baby boys, each 10 gram of yellow wine, add water and decocted 20 minutes for 300 milliliters.
CN2008101812769A 2008-11-13 2008-11-13 Medicine for treating gynecology postpartum disease and preparation method thereof Expired - Fee Related CN101417087B (en)

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CN102085352B (en) * 2011-01-28 2012-05-23 浙江大学 Traditional Chinese medicine composition for preventing and controlling intrauterine residues after medicinal abortion and application thereof
CN102228634B (en) * 2011-06-27 2012-09-05 张永福 Traditional Chinese medicine for treating postpartum gynecological disease
CN104906519A (en) * 2015-07-01 2015-09-16 陈旭东 Medicine for treating female puerperal diseases
CN109865046B (en) * 2019-03-19 2021-07-20 四川大学华西第二医院 External plaster for treating postpartum body pain and preparation method thereof

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CN1695700A (en) * 2005-05-24 2005-11-16 李洪国 'Yimu' ointment and preparation method
CN1970048A (en) * 2006-12-12 2007-05-30 魏发荣 Chinese medicinal oral liquid for treating hypertension
CN101002906A (en) * 2006-01-16 2007-07-25 上海清风阁医药科技有限公司 Compounding traditional Chinese medicine, and its use

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Publication number Priority date Publication date Assignee Title
CN1695700A (en) * 2005-05-24 2005-11-16 李洪国 'Yimu' ointment and preparation method
CN101002906A (en) * 2006-01-16 2007-07-25 上海清风阁医药科技有限公司 Compounding traditional Chinese medicine, and its use
CN1970048A (en) * 2006-12-12 2007-05-30 魏发荣 Chinese medicinal oral liquid for treating hypertension

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