CN1695700A - 'Yimu' ointment and preparation method - Google Patents
'Yimu' ointment and preparation method Download PDFInfo
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- CN1695700A CN1695700A CN 200510017608 CN200510017608A CN1695700A CN 1695700 A CN1695700 A CN 1695700A CN 200510017608 CN200510017608 CN 200510017608 CN 200510017608 A CN200510017608 A CN 200510017608A CN 1695700 A CN1695700 A CN 1695700A
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Abstract
A Chinese medicine 'Yumugao' for treating gynopathy, rheumatism, cardiovascular disease, tumor etc is prepared from 17 Chinese-medicinal materials including motherwort, red sage root, Chinese angelica root, Chuan-xiong rhizome, etc.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of to cure mainly gynaecopathia, double low disease, kidney disease, cardiovascular diseases and the antineoplastic ointment controlled.
Background technology
The disease of gynecological be unable to do without " blood " word in brief, and, depression foster towards wantonly two arteries and veins mistake is the source and course that causes all diseases of gynecological.The woman is congenital with liver, and Liver Channel strongly fragrant (heat) is long-pending, dystrophy of both the heart and spleen, and kidney qi is not filled, and day invisible water is not good, dashes and appoints an obstructed Sheng, and vessels of the uterus is full etc., is to cause gynopathic main cause.In addition, gynecological diseases is often easily accompanied wasting diseases (tumor, cancer etc.); Existing Herba Leonuri paste, few during medicine, therapeutic effect is not good enough, and treatment cycle is long; However, curative effect still can not be satisfactory.
Summary of the invention
Therefore, people better treat gynopathic Chinese medicine preparation to curative effect and still have demand, up to now, also do not find the report of any relevant pharmaceutical composition of the present invention, the inventor is through research repeatedly, finally find the gynopathic Chinese medicine preparation of treatment of better efficacy, thereby finished the present invention.
The purpose of this invention is to provide a kind of gynaecopathia Chinese medicine preparation of more effectively treating.
Another object of the present invention provides this preparation method of Chinese medicine.
The consumption of drug component of the present invention is that the inventor gets through groping in a large number to sum up, and each amounts of components all has curative effect preferably in following weight parts:
Herba Leonuri 15--50 part, Radix Salviae Miltiorrhizae 15--50 part, Radix Angelicae Sinensis 12--50 part, Rhizoma Chuanxiong 10--50 part, Flos Carthami 15--50 part, Squama Manis 10--15 part, Radix Astragali 12--50 part, Rhizoma Dioscoreae 15--50 part, Rhizoma Cyperi 10--45 part, Radix Rehmanniae 12--50 part, Radix Paeoniae Alba 10--30 part, Radix Rubiae 15--45 part, Fructus Corni 15--30 part, Rhizoma Gastrodiae 10--25 part, Scorpio 10--15 part, Herba Scutellariae Barbatae 10--15 part, Herba Hedyotidis Diffusae 10--25 part;
The consumption of drug component of the present invention can also be Herba Leonuri 15--50 part, Radix Salviae Miltiorrhizae 15--50 part, Radix Angelicae Sinensis 12--50 part, Rhizoma Chuanxiong 10--50 part, Flos Carthami 15--50 part, Squama Manis 10--15 part, Radix Astragali 12--50 part, Rhizoma Dioscoreae 15--50 part, Rhizoma Cyperi 10--45 part, Radix Rehmanniae 12--50 part, Radix Paeoniae Alba 10--30 part, Radix Rubiae 15--45 part, Fructus Corni 15--30 part, Rhizoma Gastrodiae 10--25 part, Scorpio 10--15 part, Herba Scutellariae Barbatae 10--15 part, Herba Hedyotidis Diffusae 10--25 part, Radix Rehmanniae Preparata 12--50 part, Rhizoma Atractylodis Macrocephalae 12--45 part, Fructus Lycii 12--35 part, Radix Achyranthis Bidentatae 10--20 part;
The preparation method of medicine of the present invention is as follows:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae with described weight proportion decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicine of the present invention can also prepare with following method:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae of described weight proportion are used twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
If also add Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae; The preparation method of medicine of the present invention is as follows:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Achyranthis Bidentatae with described weight proportion decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicine of the present invention can also prepare with following method:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) with the Herba Leonuri of described weight proportion, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae with twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicament selection Herba Leonuri of the present invention, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae make up, make each efficacy of drugs produce synergism these drug regimens, thereby effectively treat gynaecopathia; Wherein selecting Herba Leonuri for use, is because its major function of Herba Leonuri is regulating menstruation and activating blood, promoting tissue regeneration by removing blood stasis, inducing diuresis to remove edema; Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving; Radix Angelicae Sinensis: the affair alive of enriching blood, menstruction regulating and pain relieving, moisturize laxation, cure mainly diseases such as menoxenia; Rhizoma Chuanxiong: activating QI to alleviate the depression, promoting blood circulation and stopping pain, dispeiling pathogenic wind and removing dampness; Flos Carthami: promoting blood flow to regulate menstruation, blood stasis removing pain relieving, be treatment women's passages through which vital energy circulates obstructed choice drug; Squama Manis: detumescence burst carbuncle, the stimulating milk secretion of stimulating the menstrual flow, to search wind active; The Radix Astragali: benefit is defended consolidating superficial resistance, invigorating the spleen and replenishing QI, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Rhizoma Dioscoreae: strengthening the spleen and tonifying the lung, beneficial essence is reinforced the kidney; The Radix Rehmanniae Preparata nature and flavor are sweet, tepor; GUIXIN, Liver Channel; The YIN nourishing of enriching blood; Rhizoma Cyperi: the gas in the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation, the outlet conditioning blood; Radix Rehmanniae: clearing away heat and promoting production of body fluid, nourishing the liver and kidney, tonifying blood and regulating menstruation; The Radix Paeoniae Alba: suppressing liver-YANG, the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain; Rhizoma Atractylodis Macrocephalae bitter but sweet flavor, temperature are returned spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis; Radix Rubiae: cure mainly haematemesis, epistaxis, disease such as the hematuria of having blood in stool, amenorrhea stomachache, menoxenia; Fructus Lycii has another name called fructus lycii, and nature and flavor are sweet, warm, returns liver, kidney channel, nourishing the liver and kidney, replenishing vital essence to improve eyesight; Fructus Corni: invigorating the liver and kidney, arresting seminal emission gas, solid collapse; Rhizoma Gastrodiae: dispelling wind and relieving convulsion, cure mainly headache wind syndrome of head, numb limbs and tense tendons, hemiplegia, disease such as have a dizzy spell; Radix Achyranthis Bidentatae nature and flavor hardship, acid, temperature are returned liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards; Scorpio: dispelling wind and removing obstruction in the collateral, relieving convulsion detoxify, cure mainly diseases such as apoplexy and hemiplegia; Herba Scutellariae Barbatae: heat-clearing and toxic substances removing, hemostasis dissipating blood stasis; Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, diuresis, antiinflammatory.
Blood system animal drugs such as Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis are principal agent in the side, and tool QI invigorating such as the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, circulation of qi promoting function, auxiliary principal agent make QI and blood two prosperous, qi and blood tonifying.Assistant is with quiet medicine Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, taro meat etc. in the blood, and nourishing essence and blood, kidney tonifying add essence, call with refuge: the fraud of " person of walking walks very much, the person of keeping procurator ", and to mend the deficiency of principal agent.Be equipped with ailment said due to cold or exposure and wasting diseases (tumor, cancer etc.) that Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae etc. thanks to cause to control cloudy blood deficiency in the side.
Make a general survey of this side and be the compound recipe that a kinds of traditional Chinese medicines is formed, rigorous, all medicine of medicine share, brings out the best in each other, effect is remarkable owing to select.Starting with from conscience, spleen kidney four dirty physiological characteristicies, based on the treatment gynaecopathia, is aim with YIN and YANG balance regulating, strengthening vital QI to eliminate pathogenic factors, has possessed that nourishing blood and promoting blood circulation, Yiqi and vein recovery, enriching yin and nourishing kidney, spleen invigorating are damp proof, the effect of suppressing the hyperactive liver to relieve the wind syndrome, strengthening vital QI to eliminate pathogenic factors.
The specific embodiment
The present invention is mainly made by following bulk drugs: Herba Leonuri 15--50 part, Radix Salviae Miltiorrhizae 15--50 part, Radix Angelicae Sinensis 12--50 part, Rhizoma Chuanxiong 10--50 part, Flos Carthami 15--50 part, Squama Manis 10--15 part, Radix Astragali 12--50 part, Rhizoma Dioscoreae 15--50 part, Rhizoma Cyperi 10--45 part, Radix Rehmanniae 12--50 part, Radix Paeoniae Alba 10--30 part, Radix Rubiae 15--45 part, Fructus Corni 15--30 part, Rhizoma Gastrodiae 10--25 part, Scorpio 10--15 part, Herba Scutellariae Barbatae 10--15 part, Herba Hedyotidis Diffusae 10--25 part;
The consumption of drug component of the present invention can also be Herba Leonuri 15--50 part, Radix Salviae Miltiorrhizae 15--50 part, Radix Angelicae Sinensis 12--50 part, Rhizoma Chuanxiong 10--50 part, Flos Carthami 15--50 part, Squama Manis 10--15 part, Radix Astragali 12--50 part, Rhizoma Dioscoreae 15--50 part, Rhizoma Cyperi 10--45 part, Radix Rehmanniae 12--50 part, Radix Paeoniae Alba 10--30 part, Radix Rubiae 15--45 part, Fructus Corni 15--30 part, Rhizoma Gastrodiae 10--25 part, Scorpio 10--15 part, Herba Scutellariae Barbatae 10--15 part, Herba Hedyotidis Diffusae 10--25 part, Radix Rehmanniae Preparata 12--50 part, Rhizoma Atractylodis Macrocephalae 12--45 part, Fructus Lycii 12--35 part, Radix Achyranthis Bidentatae 10--20 part;
Embodiment 1:
If drug main of the present invention is made by following bulk drugs: 15 parts of Herba Leonuris, 15 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts on Flos Carthami, 10 parts of Squama Maniss, 12 parts of the Radixs Astragali, 15 parts of Rhizoma Dioscoreaes, 10 parts of Rhizoma Cyperis, 12 parts of Radix Rehmanniae, 10 parts of the Radix Paeoniae Albas, 15 parts of Radix Rubiae, 15 parts of Fructus Corni, 10 parts in Rhizoma Gastrodiae, 10 parts of Scorpios, 10 parts of Herba Scutellariae Barbataes, 10 parts of Herba Hedyotidis Diffusaes;
Embodiment 2:
If drug main of the present invention is made by following bulk drugs: 30 parts of Herba Leonuris, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 30 parts on Flos Carthami, 12 parts of Squama Maniss, 30 parts of the Radixs Astragali, 30 parts of Rhizoma Dioscoreaes, 25 parts of Rhizoma Cyperis, 30 parts of Radix Rehmanniae, 20 parts of the Radix Paeoniae Albas, 25 parts of Radix Rubiae, 25 parts of Fructus Corni, 18 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 12 parts of Herba Scutellariae Barbataes, 18 parts of Herba Hedyotidis Diffusaes;
Embodiment 3:
If drug main of the present invention is made by following bulk drugs: 50 parts of Herba Leonuris, 50 parts of Radix Salviae Miltiorrhizaes, 50 parts of Radix Angelicae Sinensis, 50 parts of Rhizoma Chuanxiongs, 50 parts on Flos Carthami, 15 parts of Squama Maniss, 50 parts of the Radixs Astragali, 50 parts of Rhizoma Dioscoreaes, 45 parts of Rhizoma Cyperis, 50 parts of Radix Rehmanniae, 30 parts of the Radix Paeoniae Albas, 45 parts of Radix Rubiae, 30 parts of Fructus Corni, 25 parts in Rhizoma Gastrodiae, 15 parts of Scorpios, 15 parts of Herba Scutellariae Barbataes, 25 parts of Herba Hedyotidis Diffusaes;
Embodiment 4:
The consumption of drug component of the present invention can also be 15 parts of Herba Leonuris, 15 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts on Flos Carthami, 10 parts of Squama Maniss, 12 parts of the Radixs Astragali, 15 parts of Rhizoma Dioscoreaes, 10 parts of Rhizoma Cyperis, 12 parts of Radix Rehmanniae, 10 parts of the Radix Paeoniae Albas, 15 parts of Radix Rubiae, 15 parts of Fructus Corni, 10 parts in Rhizoma Gastrodiae, 10 parts of Scorpios, 10 parts of Herba Scutellariae Barbataes, 10 parts of Herba Hedyotidis Diffusaes, 12 parts in Radix Rehmanniae Preparata, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Fructus Lyciis, 10 parts of Radix Achyranthis Bidentataes;
Embodiment 5:
The consumption of drug component of the present invention can also be 30 parts of Herba Leonuris, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 30 parts on Flos Carthami, 12 parts of Squama Maniss, 30 parts of the Radixs Astragali, 30 parts of Rhizoma Dioscoreaes, 25 parts of Rhizoma Cyperis, 30 parts of Radix Rehmanniae, 20 parts of the Radix Paeoniae Albas, 25 parts of Radix Rubiae, 25 parts of Fructus Corni, 18 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 12 parts of Herba Scutellariae Barbataes, 18 parts of Herba Hedyotidis Diffusaes, 30 parts in Radix Rehmanniae Preparata, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Fructus Lyciis, 15 parts of Radix Achyranthis Bidentataes;
Embodiment 6:
The consumption of drug component of the present invention can also be 50 parts of Herba Leonuris, 50 parts of Radix Salviae Miltiorrhizaes, 50 parts of Radix Angelicae Sinensis, 50 parts of Rhizoma Chuanxiongs, 50 parts on Flos Carthami, 15 parts of Squama Maniss, 50 parts of the Radixs Astragali, 50 parts of Rhizoma Dioscoreaes, 45 parts of Rhizoma Cyperis, 50 parts of Radix Rehmanniae, 30 parts of the Radix Paeoniae Albas, 45 parts of Radix Rubiae, 30 parts of Fructus Corni, 25 parts in Rhizoma Gastrodiae, 15 parts of Scorpios, 15 parts of Herba Scutellariae Barbataes, 25 parts of Herba Hedyotidis Diffusaes, 50 parts in Radix Rehmanniae Preparata, 45 parts of the Rhizoma Atractylodis Macrocephalaes, 35 parts of Fructus Lyciis, 20 parts of Radix Achyranthis Bidentataes;
The preparation method of medicine of the present invention is as follows:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae with described weight proportion decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is injected jacketed pan and boil decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicine of the present invention can also prepare with following method:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae of described weight proportion are used twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is injected jacketed pan and boil decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
If also add Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae; The preparation method of medicine of the present invention is as follows:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Achyranthis Bidentatae with described weight proportion decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is injected jacketed pan and boil decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicine of the present invention can also prepare with following method:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) with the Herba Leonuri of described weight proportion, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, with twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is injected jacketed pan and boil decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
Medicine of the present invention can also be made pill according to conventional method.
One, medicine major function of the present invention and therapeutic domain
1, major function:
Blood circulation promoting and blood stasis dispelling, promote blood circulation, benefiting QI and nourishing blood, kidney invigorating and YANG supporting, spleen invigorating dehumidifying, nourishing YIN to relieve dryness, eliminating phlegm and calming wind, vessel softening, thrombus, reducing swelling and alleviating pain, anticancer.
2, therapeutic domain:
(1) gynaecopathia: menstrual pain (dysmenorrhea, amenorrhea, menstrual period be successively indefinite, through amount what are indefinite, the mastalgia of passing through, edema etc.) intrauterine intimitis, dysfunctional uterine hemorrhage, uterine erosion, cyclomastopathy, mastitis, breast carcinoma, hysteromyoma, fervid leukorrhagia, infertility, puerperal difficult miscellaneous diseases.
(2) disease: numb limbs and tense tendons, the whole body are painful, lumbago and skelalgia, rheumatism and rheumatoid, sciatica.
(3) apoplectic hemiplegia: hemiplegia, hypertension, cerebral thrombosis, cerebral arteriosclerosis.
(4) heart disease: heart disease, coronary heart disease, hypertensive cardiopathy, rheumatic heart disease, myocardial ischemia, pulmonary heart disease etc.
(5) kidney disease: neurasthenia, anemia, hepatitis, cirrhotic ascites, chronic edema.
(6) wasting diseases: gynecological tumor and other tumor treatment, and have certain anticancer effect.
(7) preserve youthful looks: external application can be treated the sacrificial meat cheek.
3, usage and consumption:
Oral every day three times, each 10-15 gram.It is an amount of to take the circumstances into consideration sugaring, takes after mixing it with water with wet boiled water.Take before the breakfast supper.Be a course of treatment January, and the severe case must 2-3 the course of treatment.
Two, the clinical observation of medicine of the present invention
1, physical data
Accept out-patient's 300 examples for medical treatment, be the women, the patient is divided into two groups at random, 230 examples are organized in treatment, give Drug therapy of the present invention, and matched group 70 examples have the Herba Leonuri paste treatment; Be gynaecopathia, minimum 16 years old of age wherein, maximum 76 years old, the longest 25 years the course of disease the shortest half a year, clinical treatment observation, the shortest 2 months, the longest 5 years.51 examples below 40 years old in the treatment group, 40--49 year 103 examples, 50--59 year 52 examples, 26 examples more than 60 years old; The course of disease is 55 examples below 1 year, 2--5 94 examples, 6--10 55 examples, 18 examples more than 10 years; 15 examples below 40 years old in the matched group, 40--49 year 40 examples, 50--59 year 12 examples, 3 examples more than 60 years old; The course of disease is 18 examples below 1 year, 2--5 31 examples, 6--10 16 examples, 5 examples more than 10 years; Two groups of patients are aspect mean age, the course of disease, the state of an illness, and are in a basic balance, have comparability.
2, diagnostic criteria
All case is that diagnosis is determined in diagnostic criteria by the gynaecopathia clinical manifestation all.
(1), menopathy: menoxenia after the preceded menstrual cycle mistake, or successively indefinite, surpasses more than 7 days; Many or few through measuring, through preceding, menstrual period, postmenstrual abdominal pain or amenorrhea; The continuous person more than 3 months of above-mentioned disease.
(2), leukorrheal diseases: leukorrhagia is red white, and amount is many, with stench or the pudendum scabies is overworked, or lower abdomen pain.
(3), infertility: matrimonial cohabitation was not practised contraception and the person that do not become pregnant more than 2 years after marriage.
(4), breast disease: mastitis, cyclomastopathy can (breast rise logical, one-sided or bilateral 1 or several cakings that differ in size are arranged).
(5), hysteromyoma: the single or multiple tuberositys that differ in size appear in intrauterine, with irregular bleeding, abdominal mass, pain etc.
3, Therapeutic Method
Therapeutic Method is under the voluntary prerequisite of patient, patient is divided into 2 groups at random, and 230 examples are organized in treatment, take medicine of the present invention, each 10--15 gram, every day 3 times, warm boiled water, it is an amount of to take the circumstances into consideration sugaring, 30 days is a course of treatment, 7 days at interval per course of treatment, minimum taking 2 courses of treatment, the longest taking 6 courses of treatment.Matched group is totally 70 examples, takes existing " Herba Leonuri paste ", each 15 grams, and every day 2--3 time, 30 days is a course of treatment, 7 days at interval per course of treatment, minimum taking 2 courses of treatment, the longest taking 8 courses of treatment.
4, efficacy assessment standard (being as the criterion) with clinical symptom disappearance
Cure:
(1), menstrual cycle recovers normal, through amount, all normal, disappear through preceding, menstrual period, postmenstrual abdominal pain through color.
(2), leucorrhea with red and white discharge disappears, unusual odor, the pudendum scabies is overworked or lower abdomen pain disappears, gynecologial examination is normal.
(3), conceived or given birth to child.
(4), mastalgia disappears the disappearance of breast caking.
(5), hysteromyoma disappears, menstrual cycle is normal, abdominal mass, pain disappear.
Produce effects:
(1), menstrual cycle, amount, this recoverys of color base normally alleviate greatly through preceding, menstrual period, postmenstrual abdominal pain.
(2), the leukorrhagia amount obviously reduces, stench flavor, pruritus vulvae alleviates or with lower abdomen pain.
(3), mastalgia reduces, the breast caking diminishes, deliquescing or minimizing.
(4), hysteromyoma diminishes or growth is not arranged, menstrual cycle is normal substantially, amount of bleeding obviously reduces.
Effectively:
(1), menstrual cycle recovers normally to have during menstrual blood volume more or less substantially, during stomachache or generation, or pain alleviates to some extent.
(2), the leukorrhagia amount reduces, stench flavor, pruritus vulvae alleviates or lower abdomen pain, all alleviates to some extent.
(3), mastalgia alleviates the deliquescing of breast caking.
(4), the hysteromyoma size do not change, but menstrual cycle is normal substantially, amount of bleeding reduces.
Difference (invalid):
Various symptoms do not have the changer.
5, result and analysis (seeing Table 1)
Table 1 liang group curative effect relatively
| Group | The example number | Cure | Produce effects | Effectively | Difference | Effective percentage (%) |
| The treatment group | ???230 | ??100 | ???86 | ???42 | ????2 | ?????99.1 |
| Matched group | ???70 | ??10 | ???18 | ???23 | ????19 | ?????72.9 |
The curative effect of treatment group as can be seen from Table 1 obviously is better than matched group, and its total effective rate, cure rate (99.1%, 43.5%) are all apparently higher than matched group (72.9%, 14.3%).
Claims (8)
1, a kind of Extractum Herba Leonuri is characterized in that it is mainly made by following bulk drugs: Herba Leonuri 15--50 part, Radix Salviae Miltiorrhizae 15--50 part, Radix Angelicae Sinensis 12--50 part, Rhizoma Chuanxiong 10--50 part, Flos Carthami 15--50 part, Squama Manis 10--15 part, Radix Astragali 12--50 part, Rhizoma Dioscoreae 15--50 part, Rhizoma Cyperi 10--45 part, Radix Rehmanniae 12--50 part, Radix Paeoniae Alba 10--30 part, Radix Rubiae 15-45 part, Fructus Corni 15--30 part, Rhizoma Gastrodiae 10--25 part, Scorpio 10--15 part, Herba Scutellariae Barbatae 10-15 part, Herba Hedyotidis Diffusae 10--25 part.
2, Extractum Herba Leonuri according to claim 1, wherein the consumption of a crude drug is: 30 parts of Herba Leonuris, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 30 parts on Flos Carthami, 12 parts of Squama Maniss, 30 parts of the Radixs Astragali, 30 parts of Rhizoma Dioscoreaes, 25 parts of Rhizoma Cyperis, 30 parts of Radix Rehmanniae, 20 parts of the Radix Paeoniae Albas, 25 parts of Radix Rubiae, 25 parts of Fructus Corni, 18 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 12 parts of Herba Scutellariae Barbataes, 18 parts of Herba Hedyotidis Diffusaes.
3, the preparation method of claim 1 or 2 described Extractum Herba Leonuri, it comprises the following steps:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae with described weight proportion decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
4, the preparation method of claim 1 or 2 described Extractum Herba Leonuri, it comprises the following steps:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, standby;
B) Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, the Herba Hedyotidis Diffusae of described weight proportion are used twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
5, Extractum Herba Leonuri according to claim 1, wherein crude drug also has: Radix Rehmanniae Preparata 12--50 part, Rhizoma Atractylodis Macrocephalae 12--45 part, Fructus Lycii 12-35 part, Radix Achyranthis Bidentatae 10--20 part.
6, Extractum Herba Leonuri according to claim 5, wherein the consumption of each component is: 30 parts of Herba Leonuris, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiongs, 30 parts on Flos Carthami, 12 parts of Squama Maniss, 30 parts of the Radixs Astragali, 30 parts of Rhizoma Dioscoreaes, 25 parts of Rhizoma Cyperis, 30 parts of Radix Rehmanniae, 20 parts of the Radix Paeoniae Albas, 25 parts of Radix Rubiae, 25 parts of Fructus Corni, 18 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 12 parts of Herba Scutellariae Barbataes, 18 parts of Herba Hedyotidis Diffusaes, 30 parts in Radix Rehmanniae Preparata, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Fructus Lyciis, 15 parts of Radix Achyranthis Bidentataes.
7, the preparation method of claim 5 or 6 described Extractum Herba Leonuri, it comprises the following steps:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) with Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, the Radix Rehmanniae Preparata of described weight proportion, decoct with water twice from art, Fructus Lycii, Radix Achyranthis Bidentatae, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
8, the preparation method of claim 5 or 6 described Extractum Herba Leonuri, it comprises the following steps:
A) take by weighing each crude drug Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae, standby;
B) with the Herba Leonuri of described weight proportion, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Squama Manis, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Rubiae, Fructus Corni, Rhizoma Gastrodiae, Scorpio, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Achyranthis Bidentatae with twice of 90%--95% ethanol extraction, merge ethanol extract, reclaim ethanol, filter to get filtrate;
C) filtrate is boiled decoction, evaporate moisture, obtain extractum;
D) in extractum, add pure Mel, correctives and 0.03% ethyl p-hydroxybenzoate, be thick paste and stir evenly, filter canned getting final product.
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| CN1994416B (en) * | 2006-12-28 | 2010-05-12 | 王玉秀 | Orally administered Chinese medicine for treating amenorrhvea |
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