CN1124153C - Medicinal composition for restoring cardiac collaterals and its application - Google Patents

Medicinal composition for restoring cardiac collaterals and its application Download PDF

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CN1124153C
CN1124153C CN01131203A CN01131203A CN1124153C CN 1124153 C CN1124153 C CN 1124153C CN 01131203 A CN01131203 A CN 01131203A CN 01131203 A CN01131203 A CN 01131203A CN 1124153 C CN1124153 C CN 1124153C
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CN1334121A (en
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吴以岭
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Abstract

The present invention provides the medicinal composition of medicinal compatibility with the functions of qi supplement, blood circulation activation, wind removal and spasmolysis, which aims to improve myocardial ischemia degrees and activate meridians to stop pain. The medical composition for restoring cardiac collaterals comprises one or several kinds of ginseng, pilose asiabell root, pseudostellaria root, astragalus root, white atractylodes rhizome, licorice root and Chinese yam, which clinically have reasonable dosage. Besides, the combination preparation comprises one or several kinds of leech, red sage root, chuanxiong rhizome, safflower, red peony root, lignum dalbergiae odoriferae, notoginseng, curcuma root, peach kernels, corydalis tuber, cockroach, frankincense, dragon blood, myrrh, spatholobus stem, eaglewood, zedoary, prism tuber, motherwort, trogopterus dung, achyranthes root, trichosanthis, pinellia tuber, allii, almond, aurantii, aurantii immaturus, sandalwood, nutagrass flatsedge rhizome, aucklandia root, orange peel, platycodon root, rhizoma corydalis, fleece-flower root, Chinese angelica, prepared rehmannia root, radix paeoniae alba, lilyturf root, solomonseal rhizome, borneol, grassleaved sweetflag rhizome, jujube seed, senega, amber, asarum herb, aconite root, cassia twig, epimedium, schisandra, haw, pueraria root, tuckahoe, dahurian angelica root, bupleurum root, earthworm and gastrodia tuber and one or several kinds of scorpion, periostracum cicada and centipede.

Description

A kind of treatment treating coronary heart disease and angina pectoris compositions
Technical field
The present invention relates to a kind of pharmaceutical composition, belong to the Chinese herbal and crude drugs preparations technical field, be particularly useful for treating clinically angina pectoris.
Background technology
It is coronary atherosclerotic heart disease that the medicament composing prescription of present clinical treatment coronary heart disease is conceived to " blood stasis " mostly, based on benefiting QI and nourishing blood, promoting blood circulation to remove blood stasis, be aided with reduce phlegm, circulation of qi promoting, enrich blood, removing heat from blood, pain relieving, spleen invigorating, diuretic, have one's ideas straightened out, medicine such as heat clearing away, for being that the pathogenetic feeling of oppression and pain in the chest (angina pectoris) of outbreak repeatedly then has significant limitation with coronary vasospasm.
Summary of the invention
The present invention inquires into the medicine of angina pectoris with traditional Chinese medical science network ens morbi, provide a kind of with benefiting QI for activating blood circulation, search the drug regimen of the compatibility of drugs of wind spasmolytic, improve degree of myocardial ischemia, removing obstruction in the collateral to relieve pain.
Technical scheme of the present invention is achieved in that this medicinal composition for restoring cardiac collaterals, the Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae that its composition comprises clinically reasonable dosage wherein one or more; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more and Scorpio, Periostracum Cicadae, Scolopendra one or more combination preparation wherein wherein
The ratio of the composition of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae be one or more 3-30 grams wherein; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more 1-20 grams wherein; Scorpio, Periostracum Cicadae, Scolopendra be one or more 1-15 grams wherein.
The best combination ratio of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng 3-10 gram, Hirudo 3-11 gram, Eupolyphaga Seu Steleophaga 5-10 gram, Olibanum (system) 1-5 gram, Radix Paeoniae Rubra 3-9 gram, Lignum Dalbergiae Odoriferae 1-5 gram, Lignum Santali Albi 1-5 gram, Scorpio 3-9 gram, Periostracum Cicadae 3-12 gram, Scolopendra 1-3 gram, Borneolum Syntheticum 1-7 gram, Semen Ziziphi Spinosae (stir-fry) 3-10 gram.
The application of this medicinal composition for restoring cardiac collaterals comprises the oral formulations form for the treatment of angina pectoris clinically that can be used as.
The application of described medicinal composition for restoring cardiac collaterals also comprises capsule, tablet, electuary, powder, the oral liquid formulations form for the treatment of angina pectoris clinically that can be used as.
The insect medicine that the present invention at first will search the wind spasmolytic is used for the treatment of cardiopathic drug regimen, trade name is a Tongxinluo, adopting the tall and erect ketone of sulfur ammonia to carry out pharmacological effect as the positive control medicine through Xiyuan Hospital, Chinese Medicine Academy of China studies show that: TONGXINLUO JIAONANG has the obvious effect that improves acute blood myocardial ischemia of experimental dog and myocardial infarction, alleviates degree of myocardial ischemia and ischemia scope by epicardial electrogram mapping.Obviously coronary blood flow increasing improves the blood supply oxygen supply of cardiac muscle; Improve the work done of left chamber, the pumping function of heart is strengthened.Clinical results shows through Guang-amen Hospital, China Traditional Chinese Medicine Instl: TONGXINLUO JIAONANG has obvious allevating angina pectoris, reduces seizure frequency, shortens the outbreak persistent period, improves the effect of clinical episodes symptom, sees Appendix 1.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention, and the addition manner of dosage form of the present invention and relevant auxiliary materials is identical with the conventional formulation method with ratio, no longer enumerates at this.
Embodiment: 1, Radix Ginseng 6 grams, Hirudo 10 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.2, Radix Codonopsis 3 grams, Hirudo 5 grams, Eupolyphaga Seu Steleophaga 5 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 5 grams, Periostracum Cicadae 4 grams, Scolopendra 0.5 gram, Borneolum Syntheticum 3 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.3, Radix Pseudostellariae 5 grams, Radix Salviae Miltiorrhizae 10 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.4, Radix Ginseng 5 grams, the Radix Astragali 3 grams, Hirudo 10 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 3 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.5, Radix Ginseng 10 grams, Hirudo 3 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Scorpio 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams.6, Radix Ginseng 6 grams, Hirudo 11 grams, Olibanum (system) 2 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 7 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.7, Radix Ginseng 3 grams, Hirudo 3 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.8, Radix Ginseng 10 grams, Hirudo 8 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 9 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.9, Radix Ginseng 6 grams, Hirudo 11 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (system) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 3 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (stir-fry) 5 grams.10, Radix Ginseng 10 grams, Hirudo 11 grams, Eupolyphaga Seu Steleophaga 7 grams, Radix Paeoniae Rubra 5 grams, Scorpio 9 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams.11, Radix Codonopsis 10 grams, the Radix Astragali 5 grams, Radix Paeoniae Rubra 10 grams, Flos Carthami 10 grams, Fructus Crataegi 6 grams, Scorpio 5 grams.12, Radix Ginseng 10 restrains, restrain Radix Ophiopogonis 30, Fructus Schisandrae Chinensis 9 restrains, Scorpio 6 restrains, Scolopendra 1 restrains, Periostracum Cicadae 4 restrains.13, Radix Codonopsis 30 grams, Hirudo 10 grams, Radix Angelicae Sinensis 15 grams, Radix Curcumae 10 grams, Bulbus Allii Macrostemonis 10 grams, Flos Carthami 6 grams, Radix Salviae Miltiorrhizae 10 grams, Caulis Spatholobi 6 grams, Olibanum 10 grams, Myrrha 6 grams, rhizoma sparganic 6 grams, Rhizoma Curcumae 6 grams, Scorpio 7 grams, Periostracum Cicadae 7 grams.14, Radix Salviae Miltiorrhizae 30 grams, Rhizoma Chuanxiong 10 grams, Semen Persicae 10 grams, Flos Carthami 10 grams, Pollen Tyjphae 10 grams, Oletum Trogopterori 10 grams, Rhizoma Corydalis 5-10 gram, Radix Paeoniae Rubra 10 grams, Lignum Dalbergiae Odoriferae 10 grams, Scorpio 7 grams, Scolopendra 1 gram.15, Radix Salviae Miltiorrhizae 20 grams, Rhizoma Chuanxiong 20 grams, Rhizoma Corydalis 15 grams, Radix Curcumae 10 grams, Rhizoma Acori Graminei 10 grams, Fructus Aurantii Immaturus 9 grams, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams.16, Radix Ginseng 5 grams, the Radix Astragali 15 grams, Radix Salviae Miltiorrhizae 15 grams, Herba Epimedii 15 grams, Fructus Corni 10 grams, Rhizoma Polygonati 10 grams, Ramulus Cinnamomi 9 grams, Spica Prunellae 10 grams, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams.17, the Radix Astragali 30 grams, Radix Codonopsis 15 grams, Hirudo 10 grams, Flos Carthami 15 grams, Radix Salviae Miltiorrhizae 10 grams, Rhizoma Chuanxiong 10 grams, Radix Paeoniae Rubra 10 grams, succinum 9 grams, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams.18, Radix Ginseng 10 grams, Radix Scutellariae 9 grams, Radix Glycyrrhizae Preparata 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 25 grams, Radix Aconiti Lateralis Preparata 15 grams, Radix Bupleuri 20 grams, the Rhizoma Pinelliae 15 grams, Rhizoma Zingiberis Recens 12 grams, 12 pieces in Fructus Jujubae, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams.19, Radix Pseudostellariae, each 30 gram of Caulis Spatholobi, Radix Salviae Miltiorrhizae 20 grams, Rhizoma Chuanxiong, each 12 gram of Radix Paeoniae Rubra, Radix Notoginseng powder 10 grams (dashing), Radix Curcumae 15 grams, Radix Glycyrrhizae Preparata 6 grams, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams.20, the Radix Astragali 40 grams, Radix Codonopsis 25 grams, Radix Salviae Miltiorrhizae 25 grams, Rhizoma Chuanxiong 25 grams, Radix Notoginseng powder 10 grams (dashing), Fructus Crataegi 15 grams, Scorpio 7 grams, Scolopendra 1 gram, Periostracum Cicadae 7 grams, Radix Glycyrrhizae 6 grams.21, Fructus Trichosanthis 10 grams, Bulbus Allii Macrostemonis 10 grams, Radix Salviae Miltiorrhizae 9 grams, Lignum Dalbergiae Odoriferae 9 grams, Rhizoma Cyperi 6 grams, Scorpio 5 grams, Scolopendra 3 grams.22, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 20 grams, Poria 20 grams, Fructus Trichosanthis 25 grams, Lignum Aquilariae Resinatum 10 grams, Lignum Dalbergiae Odoriferae 10 grams, Radix Glycyrrhizae Preparata 10 grams, Scolopendra 2 grams, Periostracum Cicadae 12 grams.23, Herba Epimedii 15 grams, Fructus Corni 10 grams, Rhizoma Polygonati 10 grams, Ramulus Cinnamomi 9 grams, Radix Salviae Miltiorrhizae 10 grams, Radix Curcumae 9 grams, Scorpio 3 grams.24, Radix Bupleuri 18 grams, Rhizoma Cyperi 89 grams, Fructus Aurantii 12 grams, the Radix Paeoniae Alba 12 grams, Rhizoma Chuanxiong 12 grams, Pericarpium Citri Reticulatae 10 grams, Radix Glycyrrhizae 6 grams, Scolopendra 6 grams.

Claims (7)

1, a kind of treatment treating coronary heart disease and angina pectoris compositions is characterized in that the raw material for preparing its active ingredient comprises: Radix Ginseng 3-10 gram, Hirudo 3-11 gram, Eupolyphaga Seu Steleophaga 5-10 gram, Olibanum (processed) 1-5 gram, Radix Paeoniae Rubra 3-9 gram, Lignum Dalbergiae Odoriferae 1-5 gram, Lignum Santali Albi 1-5 gram, Scorpio 3-9 gram, Periostracum Cicadae 3-12 gram, Scolopendra 1-3 gram, Borneolum Syntheticum 1-7 gram, Semen Ziziphi Spinosae (parched) 3-10 gram.
2, extensively treating according to claim 1 is treated the treating coronary heart disease and angina pectoris compositions, and the raw material that wherein prepares its active ingredient comprises: Radix Ginseng 6 grams, Hirudo 10 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (processed) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (parched) 5 grams.
3, extensively treating according to claim 1 is treated the treating coronary heart disease and angina pectoris compositions, and the raw material that wherein prepares its active ingredient comprises: Radix Ginseng 10 grams, Hirudo 8 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (processed) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 9 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (parched) 5 grams.
4, extensively treating according to claim 1 is treated the treating coronary heart disease and angina pectoris compositions, and the raw material that wherein prepares its active ingredient comprises: Radix Ginseng 6 grams, Hirudo 11 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (processed) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 3 grams, Periostracum Cicadae 7 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (parched) 5 grams.
5, extensively treating according to claim 1 is treated the treating coronary heart disease and angina pectoris compositions, and the raw material that wherein prepares its active ingredient comprises: Radix Ginseng 5 grams, the Radix Astragali 3 grams, Hirudo 10 grams, Eupolyphaga Seu Steleophaga 7 grams, Olibanum (processed) 2 grams, Radix Paeoniae Rubra 5 grams, Lignum Dalbergiae Odoriferae 2 grams, Lignum Santali Albi 2 grams, Scorpio 7 grams, Periostracum Cicadae 3 grams, Scolopendra 1 gram, Borneolum Syntheticum 5 grams, Semen Ziziphi Spinosae (parched) 5 grams.
6, according to any one described treatment treating coronary heart disease and angina pectoris compositions among the claim 1-6, it is characterized in that described compositions is the oral formulations form.
7, treatment treating coronary heart disease and angina pectoris compositions according to claim 6 is characterized in that described compositions is capsule, tablet, electuary, powder, oral liquid formulations form.
CN01131203A 2001-08-31 2001-08-31 Medicinal composition for restoring cardiac collaterals and its application Expired - Lifetime CN1124153C (en)

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