CN1334121A - A kind of Tongxinluo medicinal composition and its application - Google Patents

A kind of Tongxinluo medicinal composition and its application Download PDF

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CN1334121A
CN1334121A CN01131203A CN01131203A CN1334121A CN 1334121 A CN1334121 A CN 1334121A CN 01131203 A CN01131203 A CN 01131203A CN 01131203 A CN01131203 A CN 01131203A CN 1334121 A CN1334121 A CN 1334121A
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tongxinluo
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CN1124153C (en
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吴以岭
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Abstract

本发明提供一种以益气活血、搜风解痉的药物配伍的药物组合,改善心肌缺血程度,通络止痛。这种通心络药物组合物的组成包括临床上合理剂量的人参、党参、太子参、黄芪、白术、甘草、山药其中一种或几种;水蛭、丹参、川芎、红花、赤芍、降香、三七、郁金、桃仁、延胡索、土鳖虫、乳香、血竭、没药、鸡血藤、沉香、莪术、三棱、益母草、五灵脂、牛膝、瓜蒌、半夏、薤白、杏仁、枳壳、枳实、檀香、香附、木香、陈皮、桔梗、元胡、何首乌、当归、熟地黄、白芍、麦冬、黄精、冰片、石菖蒲、酸枣仁、远志、琥珀、细辛、附子、桂枝、淫羊藿、五味子、山楂、葛根、茯苓、白芷、柴胡、地龙、天麻其中一种或几种与全蝎、蝉蜕、蜈蚣其中一种或几种的组合制剂。The present invention provides a medicine combination with the medicine compatibility of replenishing qi and activating blood circulation, searching wind and relieving spasm, improving the degree of myocardial ischemia, dredging collaterals and relieving pain. The composition of this Tongxinluo pharmaceutical composition includes one or more of ginseng, Codonopsis pilosula, Radix Pseudostellariae, Radix Astragali, Atractylodes macrocephala, licorice, and yam in clinically reasonable doses; Incense, notoginseng, turmeric, peach kernel, corydalis, wood beetle, frankincense, dried blood, myrrh, milletus, agarwood, curcuma, trigonum, motherwort, wulingzhi, achyranthes bidentata, fennel, pinellia, scallion , almond, aurantium husk, citrus aurantium, sandalwood, Cyperus cyperus, woody fragrance, tangerine peel, bellflower, Yuanhu, Polygonum multiflorum, angelica, rehmannia glutinosa, white peony root, Ophiopogon japonicus, Polygonatum, borneol, Shichangpu, jujube seed, polygala, One or more of amber, asarum, aconite, cinnamon twig, epimedium, schisandra, hawthorn, kudzu root, poria cocos, angelica dahurica, Bupleurum, earthworm, gastrodia elata and one or more of scorpion, cicada slough, and centipede combination preparations.

Description

A kind of medicinal composition for restoring cardiac collaterals and application
Technical field
This utility model relates to a kind of medicinal composition for restoring cardiac collaterals and application, belongs to the Chinese herbal and crude drugs preparations technical field, is particularly useful for treating clinically angina pectoris.
Background technology
It is coronary atherosclerotic heart disease that the medicament composing prescription of present clinical treatment coronary heart disease is conceived to " blood stasis " mostly, based on benefiting QI and nourishing blood, promoting blood circulation to remove blood stasis, be aided with reduce phlegm, circulation of qi promoting, enrich blood, removing heat from blood, pain relieving, spleen invigorating, diuretic, have one's ideas straightened out, medicine such as heat clearing away, for being that the pathogenetic feeling of oppression and pain in the chest (angina pectoris) of outbreak repeatedly then has significant limitation with coronary vasospasm.
Summary of the invention
The present invention inquires into the medicine of angina pectoris with traditional Chinese medical science network ens morbi, provide a kind of with benefiting QI for activating blood circulation, search the drug regimen of the compatibility of drugs of wind spasmolytic, improve degree of myocardial ischemia, removing obstruction in the collateral to relieve pain.
Technical scheme of the present invention is achieved in that this medicinal composition for restoring cardiac collaterals, the Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae that its composition comprises clinically reasonable dosage wherein one or more; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more and Scorpio, Periostracum Cicadae, Scolopendra one or more combination preparation wherein wherein.
The ratio of the composition of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae be one or more 3-30 grams wherein; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more 1-20 grams wherein; Scorpio, Periostracum Cicadae, Scolopendra be one or more 1-15 grams wherein.
The best combination ratio of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng 3-10 gram, Hirudo 3-11 gram, Eupolyphaga Seu Steleophaga 5-10 gram, Olibanum (system) 1-5 gram, Radix Paeoniae Rubra 3-9 gram, Lignum Dalbergiae Odoriferae 1-5 gram, Lignum Santali Albi 1-5 gram, Scorpio 3-9 gram, Periostracum Cicadae 3-12 gram, Scolopendra 1-3 gram, Borneolum Syntheticum 1-7 gram, Semen Ziziphi Spinosae (stir-fry) 3-10 gram.
The application of this medicinal composition for restoring cardiac collaterals comprises the oral formulations form for the treatment of angina pectoris clinically that can be used as.
The application of described medicinal composition for restoring cardiac collaterals also comprises capsule, tablet, electuary, powder, the oral liquid formulations form for the treatment of angina pectoris clinically that can be used as.
The insect medicine that the present invention at first will search the wind spasmolytic is used for the treatment of cardiopathic drug regimen, trade name is a Tongxinluo, adopting the tall and erect ketone of sulfur ammonia to carry out pharmacological effect as the positive control medicine through Xiyuan Hospital, Chinese Medicine Academy of China studies show that: TONGXINLUO JIAONANG has the obvious effect that improves acute blood myocardial ischemia of experimental dog and myocardial infarction, alleviates degree of myocardial ischemia and ischemia scope by epicardial electrogram mapping.Obviously coronary blood flow increasing improves the blood supply oxygen supply of cardiac muscle; Improve the work done of left chamber, the pumping function of heart is strengthened.Clinical results shows through Guang-amen Hospital, China Traditional Chinese Medicine Instl: TONGXINLUO JIAONANG has obvious allevating angina pectoris, reduces seizure frequency, shortens the outbreak persistent period, improves the effect of clinical episodes symptom, sees Appendix 1.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention, The addition manner of dosage form of the present invention and relevant auxiliary materials and ratio and conventional formulation method are mutually With, no longer enumerate at this.
Embodiment: 1, ginseng 6 grams, leech 10 grams, ground bettle 7 grams, frankincense (system) 2 restrain, the radix paeoniae rubrathe 5 restrains, Dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, acid Jujube kernel (stir-fry) 5 grams. 2, Radix Codonopsis 3 grams, leech 5 grams, ground bettle 5 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 5 grams, cicada slough 4 grams, centipede 0.5 gram, borneol 3 grams, acid Jujube kernel (stir-fry) 5 grams. 3, radix pseudostellariae 5 grams, the red sage root 10 grams, ground bettle 7 grams, frankincense (system) 2 restrain, the radix paeoniae rubrathe 5 restrains, Dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, acid Jujube kernel (stir-fry) 5 grams. 4, ginseng 5 grams, the Radix Astragali 3 grams, leech 10 grams, ground bettle 7 grams, frankincense (system) 2 grams, red Chinese herbaceous peony 5 grams, dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 3 grams, centipede 1 gram, borneol 5 Gram, spina date seed (stir-fry) 5 grams. 5, ginseng 10 grams, leech 3 grams, ground bettle 7 grams, frankincense (system) 2 grams, scorpio 7 grams, Wu Centipede 1 gram, borneol 5 grams. 6, ginseng 6 grams, leech 11 grams, frankincense (system) 2 grams, dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, spina date seed (stir-fry) 5 grams. 7, ginseng 3 grams, leech 3 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, spina date seed (stir-fry) 5 grams. 8, ginseng 10 grams, leech 8 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 9 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, wild jujube Benevolence (stir-fry) 5 grams. 9, ginseng 6 grams, leech 11 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 3 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, wild jujube Benevolence (stir-fry) 5 grams. 10, ginseng 10 grams, leech 11 grams, ground bettle 7 grams, the radix paeoniae rubrathe 5 grams, scorpio 9 grams, cicada slough 7 Gram, centipede 1 gram, borneol 5 grams. 11, Radix Codonopsis 10 grams, the Radix Astragali 5 grams, the radix paeoniae rubrathe 10 grams, safflower 10 grams, hawthorn 6 grams, scorpio 5 Gram. 12, ginseng 10 restrains, restrain the tubers of dwarf lilyturf 30, the fruit of Chinese magnoliavine 9 restrains, scorpio 6 restrains, centipede 1 restrains, cicada slough 4 Gram. 13, Radix Codonopsis 30 grams, leech 10 grams, Radix Angelicae Sinensis 15 grams, root tuber of aromatic turmeric 10 grams, Longstamen Onion Bulb 10 grams, red Spend 6 grams, the red sage root 10 gram, reticulate millettia 6 grams, frankincense 10 grams, myrrh 6 grams, triangular 6 grams, Curcuma zedoary 6 grams, scorpio 7 grams, cicada slough 7 grams. 14, the red sage root 30 grams, Ligusticum wallichii 10 grams, peach kernel 10 grams, safflower 10 grams, Pollen Typhae 10 grams, five Spirit fat 10 grams, corydalis tuber 5-10 gram, the radix paeoniae rubrathe 10 grams, dalbergia wood 10 grams, scorpio 7 grams, centipede 1 gram. 15, the red sage root 20 grams, Ligusticum wallichii 20 grams, corydalis tuber 15 grams, root tuber of aromatic turmeric 10 grams, calamus 10 grams, trifoliate orange Real 9 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 16, ginseng 5 grams, the Radix Astragali 15 grams, the red sage root 15 grams, barrenwort 15 restrain, dogwood fruit 10 restrains, Sealwort 10 grams, cassia twig 9 grams, selfheal 10 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 17, the Radix Astragali 30 grams, Radix Codonopsis 15 grams, leech 10 grams, safflower 15 grams, the red sage root 10 grams, Ligusticum wallichii 10 grams, the radix paeoniae rubrathe 10 grams, amber 9 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 18, ginseng 10 grams, the root of large-flowered skullcap 9 grams, honey-fried licorice root 15 grams, Radix Angelicae Sinensis 15 grams, Ligusticum wallichii 25 grams, attached Son 15 grams, radix bupleuri 20 grams, the tuber of pinellia 15 grams, ginger 12 grams, 12 pieces in date, scorpio 7 restrain, Centipede 1 gram, cicada slough 7 grams. 19, radix pseudostellariae, each 30 gram of reticulate millettia, the red sage root 20 grams, Ligusticum wallichii, each 12 gram of the radix paeoniae rubrathe, Radix Notoginseng powder 10 grams (punching), root tuber of aromatic turmeric 15 grams, honey-fried licorice root 6 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 20, the Radix Astragali 40 gram, Radix Codonopsis 25 grams, the red sage root 25 grams, Ligusticum wallichii 25 grams, Radix Notoginseng powder 10 grams (punching), Hawthorn 15 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams, Radix Glycyrrhizae 6 grams. 21, Snakegourd Fruit 10 grams, Longstamen Onion Bulb 10 grams, the red sage root 9 grams, dalbergia wood 9 grams, rhizoma cyperi 6 grams, scorpio 5 Gram, centipede 3 grams. 22, the tuber of pinellia 10 grams, dried orange peel 20 grams, Poria cocos 20 grams, Snakegourd Fruit 25 grams, agalloch eaglewood 10 grams, dalbergia wood 10 grams, honey-fried licorice root 10 grams, centipede 2 grams, cicada slough 12 grams. 23, barrenwort 15 grams, dogwood fruit 10 grams, sealwort 10 grams, cassia twig 9 restrain, the red sage root 10 restrains, Root tuber of aromatic turmeric 9 grams, scorpio 3 grams. 24, radix bupleuri 18 grams, rhizoma cyperi 89 grams, Fructus Aurantii 12 grams, the root of herbaceous peony 12 grams, Ligusticum wallichii 12 grams, dried orange peel 10 grams, Radix Glycyrrhizae 6 grams, centipede 6 grams.

Claims (5)

1、一种通心络药物组合物，其组成包括临床上合理剂量的人参、党参、太子参、黄芪、白术、甘草、山药其中一种或几种；水蛭、丹参、川芎、红花、赤芍、降香、三七、郁金、桃仁、延胡索、土鳖虫、乳香、血竭、没药、鸡血藤、沉香、莪术、三棱、益母草、五灵脂、牛膝、瓜蒌、半夏、薤白、杏仁、枳壳、枳实、檀香、香附、木香、陈皮、桔梗、元胡、何首乌、当归、熟地黄、白芍、麦冬、黄精、冰片、石菖蒲、酸枣仁、远志、琥珀、细辛、附子、桂枝、淫羊藿、五味子、山楂、葛根、茯苓、白芷、柴胡、地龙、天麻其中一种或几种与全蝎、蝉蜕、蜈蚣其中一种或几种的组合制剂。1. A Tongxinluo medicinal composition, which comprises one or more of ginseng, codonopsis, heterophylla, astragalus, atractylodes macrocephala, licorice, and yam in clinically reasonable doses; Paeoniae, Dalbergia, Panax notoginseng, Turmeric, Peach Kernel, Corydalis Corydalis, Wood Beetle, Frankincense, Dried Blood, Myrrh, Millae Spatholobus, Agarwood, Curcuma, Sanleng, Motherwort, Wulingzhi, Achyranthes bidentata, Trichosanthes, Banana Summer, scallion, almond, citrus aurantium, citrus aurantii, sandalwood, Cyperus cyperi, woody, tangerine peel, platycodon grandiflorum, Yuanhu, Polygonum multiflorum, Angelica, rehmannia glutinosa, white peony root, Ophiopogon japonicus, Polygonatum, Borneol, Shichangpu, Suanzaoren , Polygala, Amber, Asarum, Aconite, Guizhi, Epimedium, Schisandra, Hawthorn, Pueraria, Poria, Angelica, Bupleurum, Earthworm, Tianma, one or more of them and Scorpion, Cicada, Centipede or a combination of several. 2、根据权利要求1所述的通心络药物组合物，其特征在于所述的组成的比例包括：人参、党参、太子参、黄芪、白术、甘草、山药其中一种或几种3-30克；水蛭、丹参、川芎、红花、赤芍、降香、三七、郁金、桃仁、延胡索、土鳖虫、乳香、血竭、没药、鸡血藤、沉香、莪术、三棱、益母草、五灵脂、牛膝、瓜蒌、半夏、薤白、杏仁、枳壳、枳实、檀香、香附、木香、陈皮、桔梗、元胡、何首乌、当归、熟地黄、白芍、麦冬、黄精、冰片、石菖蒲、酸枣仁、远志、琥珀、细辛、附子、桂枝、淫羊藿、五味子、山楂、葛根、茯苓、白芷、柴胡、地龙、天麻其中一种或几种1-20克；全蝎、蝉蜕、蜈蚣其中一种或几种1-15克。2. The Tongxinluo medicinal composition according to claim 1, characterized in that the ratio of the composition includes: one or more of 3-30 Grams: leech, salvia, chuanxiong, safflower, red peony, balsamic, notoginseng, turmeric, peach kernel, corydalis, wood beetle, frankincense, blood dried, myrrh, milletus, agarwood, curcuma, trigonum, motherwort , Wulingzhi, Achyranthes bidentata, Gualou, pinellia, scallion, almond, citrus aurantium, citrus aurantium, sandalwood, Cyperus cyperus, woody fragrance, tangerine peel, platycodon grandiflorum, Yuanhu, Polygonum multiflorum, Angelica, rehmannia glutinosa, peony root, Ophiopogon japonicus, sealwort, borneol, stone calamus, jujube seed, polygala, amber, asarum, aconite, cinnamon twig, epimedium, schisandra, hawthorn, kudzu root, poria cocos, angelica dahurica, bupleurum, earthworm, gastrodia elata or one of them 1-20 grams for several kinds; 1-15 grams for one or several kinds of scorpion, cicada slough, and centipede. 3、根据权利要求1或2所述的通心络药物组合物，其特征在于所述的组合物包括人参3-10克、水蛭3-11克、土鳖虫5-10克、乳香(制)1-5克、赤芍3-9克、降香1-5克、檀香1-5克、全蝎3-9克、蝉蜕3-12克、蜈蚣1-3克、冰片1-7克、酸枣仁(炒)3-10克。3. The Tongxinluo medicinal composition according to claim 1 or 2, characterized in that the composition comprises 3-10 grams of ginseng, 3-11 grams of leech, 5-10 grams of ground beetle, frankincense (manufactured) 1-5 grams, 3-9 grams of red peony, 1-5 grams of Jiangxiang, 1-5 grams of sandalwood, 3-9 grams of scorpion, 3-12 grams of cicada, 1-3 grams of centipede, 1-7 grams of borneol 3. Suanzaoren (fried) 3-10 grams. 4、一种通心络药物组合物的应用，其特征在于所述的组合物可以作为临床上治疗冠心病心绞痛的口服制剂形式。4. The application of a Tongxinluo pharmaceutical composition, characterized in that the composition can be used as an oral preparation for the clinical treatment of angina pectoris of coronary heart disease. 5、根据权利要求4所述的通心络药物组合物的应用，其特征在于所述的组合物可以作为临床上治疗冠心病心绞痛的胶囊、片剂、冲剂、散剂、口服液制剂形式。5. The application of the Tongxinluo pharmaceutical composition according to claim 4, characterized in that the composition can be used as capsules, tablets, granules, powders and oral liquid preparations for the clinical treatment of coronary heart disease and angina pectoris.
CN01131203A 2001-08-31 2001-08-31 Medicinal composition for restoring cardiac collaterals and its application Expired - Lifetime CN1124153C (en)

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