CN1334121A - Medicinal composition for restoring cardiac collaterals and its application - Google Patents

Medicinal composition for restoring cardiac collaterals and its application Download PDF

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CN1334121A
CN1334121A CN01131203A CN01131203A CN1334121A CN 1334121 A CN1334121 A CN 1334121A CN 01131203 A CN01131203 A CN 01131203A CN 01131203 A CN01131203 A CN 01131203A CN 1334121 A CN1334121 A CN 1334121A
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CN1124153C (en
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吴以岭
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Abstract

A medicine composition for treating myocardial ischemia and removing obstruction in circulation of channels and collaterals is prepared from at most 66 Chinese-medicinal materials including ginseng, leach, astragalus root, red sage root, scorpion, etc.

Description

A kind of medicinal composition for restoring cardiac collaterals and application
Technical field
This utility model relates to a kind of medicinal composition for restoring cardiac collaterals and application, belongs to the Chinese herbal and crude drugs preparations technical field, is particularly useful for treating clinically angina pectoris.
Background technology
It is coronary atherosclerotic heart disease that the medicament composing prescription of present clinical treatment coronary heart disease is conceived to " blood stasis " mostly, based on benefiting QI and nourishing blood, promoting blood circulation to remove blood stasis, be aided with reduce phlegm, circulation of qi promoting, enrich blood, removing heat from blood, pain relieving, spleen invigorating, diuretic, have one's ideas straightened out, medicine such as heat clearing away, for being that the pathogenetic feeling of oppression and pain in the chest (angina pectoris) of outbreak repeatedly then has significant limitation with coronary vasospasm.
Summary of the invention
The present invention inquires into the medicine of angina pectoris with traditional Chinese medical science network ens morbi, provide a kind of with benefiting QI for activating blood circulation, search the drug regimen of the compatibility of drugs of wind spasmolytic, improve degree of myocardial ischemia, removing obstruction in the collateral to relieve pain.
Technical scheme of the present invention is achieved in that this medicinal composition for restoring cardiac collaterals, the Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae that its composition comprises clinically reasonable dosage wherein one or more; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more and Scorpio, Periostracum Cicadae, Scolopendra one or more combination preparation wherein wherein.
The ratio of the composition of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae be one or more 3-30 grams wherein; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi.YANG invigorating: Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae be one or more 1-20 grams wherein; Scorpio, Periostracum Cicadae, Scolopendra be one or more 1-15 grams wherein.
The best combination ratio of described medicinal composition for restoring cardiac collaterals comprises: Radix Ginseng 3-10 gram, Hirudo 3-11 gram, Eupolyphaga Seu Steleophaga 5-10 gram, Olibanum (system) 1-5 gram, Radix Paeoniae Rubra 3-9 gram, Lignum Dalbergiae Odoriferae 1-5 gram, Lignum Santali Albi 1-5 gram, Scorpio 3-9 gram, Periostracum Cicadae 3-12 gram, Scolopendra 1-3 gram, Borneolum Syntheticum 1-7 gram, Semen Ziziphi Spinosae (stir-fry) 3-10 gram.
The application of this medicinal composition for restoring cardiac collaterals comprises the oral formulations form for the treatment of angina pectoris clinically that can be used as.
The application of described medicinal composition for restoring cardiac collaterals also comprises capsule, tablet, electuary, powder, the oral liquid formulations form for the treatment of angina pectoris clinically that can be used as.
The insect medicine that the present invention at first will search the wind spasmolytic is used for the treatment of cardiopathic drug regimen, trade name is a Tongxinluo, adopting the tall and erect ketone of sulfur ammonia to carry out pharmacological effect as the positive control medicine through Xiyuan Hospital, Chinese Medicine Academy of China studies show that: TONGXINLUO JIAONANG has the obvious effect that improves acute blood myocardial ischemia of experimental dog and myocardial infarction, alleviates degree of myocardial ischemia and ischemia scope by epicardial electrogram mapping.Obviously coronary blood flow increasing improves the blood supply oxygen supply of cardiac muscle; Improve the work done of left chamber, the pumping function of heart is strengthened.Clinical results shows through Guang-amen Hospital, China Traditional Chinese Medicine Instl: TONGXINLUO JIAONANG has obvious allevating angina pectoris, reduces seizure frequency, shortens the outbreak persistent period, improves the effect of clinical episodes symptom, sees Appendix 1.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention, The addition manner of dosage form of the present invention and relevant auxiliary materials and ratio and conventional formulation method are mutually With, no longer enumerate at this.
Embodiment: 1, ginseng 6 grams, leech 10 grams, ground bettle 7 grams, frankincense (system) 2 restrain, the radix paeoniae rubrathe 5 restrains, Dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, acid Jujube kernel (stir-fry) 5 grams. 2, Radix Codonopsis 3 grams, leech 5 grams, ground bettle 5 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 5 grams, cicada slough 4 grams, centipede 0.5 gram, borneol 3 grams, acid Jujube kernel (stir-fry) 5 grams. 3, radix pseudostellariae 5 grams, the red sage root 10 grams, ground bettle 7 grams, frankincense (system) 2 restrain, the radix paeoniae rubrathe 5 restrains, Dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, acid Jujube kernel (stir-fry) 5 grams. 4, ginseng 5 grams, the Radix Astragali 3 grams, leech 10 grams, ground bettle 7 grams, frankincense (system) 2 grams, red Chinese herbaceous peony 5 grams, dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 3 grams, centipede 1 gram, borneol 5 Gram, spina date seed (stir-fry) 5 grams. 5, ginseng 10 grams, leech 3 grams, ground bettle 7 grams, frankincense (system) 2 grams, scorpio 7 grams, Wu Centipede 1 gram, borneol 5 grams. 6, ginseng 6 grams, leech 11 grams, frankincense (system) 2 grams, dalbergia wood 2 grams, santal 2 grams, scorpio 7 grams, cicada slough 7 grams, spina date seed (stir-fry) 5 grams. 7, ginseng 3 grams, leech 3 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, spina date seed (stir-fry) 5 grams. 8, ginseng 10 grams, leech 8 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 9 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, wild jujube Benevolence (stir-fry) 5 grams. 9, ginseng 6 grams, leech 11 grams, ground bettle 7 grams, frankincense (system) 2 grams, the radix paeoniae rubrathe 5 restrain, fall Fragrant 2 grams, santal 2 grams, scorpio 3 grams, cicada slough 7 grams, centipede 1 gram, borneol 5 grams, wild jujube Benevolence (stir-fry) 5 grams. 10, ginseng 10 grams, leech 11 grams, ground bettle 7 grams, the radix paeoniae rubrathe 5 grams, scorpio 9 grams, cicada slough 7 Gram, centipede 1 gram, borneol 5 grams. 11, Radix Codonopsis 10 grams, the Radix Astragali 5 grams, the radix paeoniae rubrathe 10 grams, safflower 10 grams, hawthorn 6 grams, scorpio 5 Gram. 12, ginseng 10 restrains, restrain the tubers of dwarf lilyturf 30, the fruit of Chinese magnoliavine 9 restrains, scorpio 6 restrains, centipede 1 restrains, cicada slough 4 Gram. 13, Radix Codonopsis 30 grams, leech 10 grams, Radix Angelicae Sinensis 15 grams, root tuber of aromatic turmeric 10 grams, Longstamen Onion Bulb 10 grams, red Spend 6 grams, the red sage root 10 gram, reticulate millettia 6 grams, frankincense 10 grams, myrrh 6 grams, triangular 6 grams, Curcuma zedoary 6 grams, scorpio 7 grams, cicada slough 7 grams. 14, the red sage root 30 grams, Ligusticum wallichii 10 grams, peach kernel 10 grams, safflower 10 grams, Pollen Typhae 10 grams, five Spirit fat 10 grams, corydalis tuber 5-10 gram, the radix paeoniae rubrathe 10 grams, dalbergia wood 10 grams, scorpio 7 grams, centipede 1 gram. 15, the red sage root 20 grams, Ligusticum wallichii 20 grams, corydalis tuber 15 grams, root tuber of aromatic turmeric 10 grams, calamus 10 grams, trifoliate orange Real 9 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 16, ginseng 5 grams, the Radix Astragali 15 grams, the red sage root 15 grams, barrenwort 15 restrain, dogwood fruit 10 restrains, Sealwort 10 grams, cassia twig 9 grams, selfheal 10 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 17, the Radix Astragali 30 grams, Radix Codonopsis 15 grams, leech 10 grams, safflower 15 grams, the red sage root 10 grams, Ligusticum wallichii 10 grams, the radix paeoniae rubrathe 10 grams, amber 9 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 18, ginseng 10 grams, the root of large-flowered skullcap 9 grams, honey-fried licorice root 15 grams, Radix Angelicae Sinensis 15 grams, Ligusticum wallichii 25 grams, attached Son 15 grams, radix bupleuri 20 grams, the tuber of pinellia 15 grams, ginger 12 grams, 12 pieces in date, scorpio 7 restrain, Centipede 1 gram, cicada slough 7 grams. 19, radix pseudostellariae, each 30 gram of reticulate millettia, the red sage root 20 grams, Ligusticum wallichii, each 12 gram of the radix paeoniae rubrathe, Radix Notoginseng powder 10 grams (punching), root tuber of aromatic turmeric 15 grams, honey-fried licorice root 6 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams. 20, the Radix Astragali 40 gram, Radix Codonopsis 25 grams, the red sage root 25 grams, Ligusticum wallichii 25 grams, Radix Notoginseng powder 10 grams (punching), Hawthorn 15 grams, scorpio 7 grams, centipede 1 gram, cicada slough 7 grams, Radix Glycyrrhizae 6 grams. 21, Snakegourd Fruit 10 grams, Longstamen Onion Bulb 10 grams, the red sage root 9 grams, dalbergia wood 9 grams, rhizoma cyperi 6 grams, scorpio 5 Gram, centipede 3 grams. 22, the tuber of pinellia 10 grams, dried orange peel 20 grams, Poria cocos 20 grams, Snakegourd Fruit 25 grams, agalloch eaglewood 10 grams, dalbergia wood 10 grams, honey-fried licorice root 10 grams, centipede 2 grams, cicada slough 12 grams. 23, barrenwort 15 grams, dogwood fruit 10 grams, sealwort 10 grams, cassia twig 9 restrain, the red sage root 10 restrains, Root tuber of aromatic turmeric 9 grams, scorpio 3 grams. 24, radix bupleuri 18 grams, rhizoma cyperi 89 grams, Fructus Aurantii 12 grams, the root of herbaceous peony 12 grams, Ligusticum wallichii 12 grams, dried orange peel 10 grams, Radix Glycyrrhizae 6 grams, centipede 6 grams.

Claims (5)

1, the Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae that a kind of medicinal composition for restoring cardiac collaterals, its composition comprise clinically reasonable dosage wherein one or more; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae is one or more and Scorpio wherein, Periostracum Cicadae, Scolopendra is one or more combination preparation wherein.
2, medicinal composition for restoring cardiac collaterals according to claim 1 is characterized in that the ratio of described composition comprises: Radix Ginseng, Radix Codonopsis, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae be one or more 3-30 grams wherein; Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Curcumae, Semen Persicae, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Olibanum, Sanguis Draxonis, Myrrha, Caulis Spatholobi, Lignum Aquilariae Resinatum, Rhizoma Curcumae, rhizoma sparganic, Herba Leonuri, Oletum Trogopterori, Radix Achyranthis Bidentatae, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Fructus Aurantii, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Cyperi, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Corydalis, Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati, Borneolum Syntheticum, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Radix Polygalae, succinum, Herba Asari, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Crataegi, Radix Puerariae, Poria, the Radix Angelicae Dahuricae, Radix Bupleuri, Pheretima, Rhizoma Gastrodiae is one or more 1-20 grams wherein; Scorpio, Periostracum Cicadae, Scolopendra be one or more 1-15 grams wherein.
3, medicinal composition for restoring cardiac collaterals according to claim 1 and 2 is characterized in that described compositions comprises Radix Ginseng 3-10 gram, Hirudo 3-11 gram, Eupolyphaga Seu Steleophaga 5-10 gram, Olibanum (system) 1-5 gram, Radix Paeoniae Rubra 3-9 gram, Lignum Dalbergiae Odoriferae 1-5 gram, Lignum Santali Albi 1-5 gram, Scorpio 3-9 gram, Periostracum Cicadae 3-12 gram, Scolopendra 1-3 gram, Borneolum Syntheticum 1-7 gram, Semen Ziziphi Spinosae (stir-fry) 3-10 gram.
4, a kind of application of medicinal composition for restoring cardiac collaterals is characterized in that described compositions can be used as the oral formulations form for the treatment of angina pectoris clinically.
5, the application of medicinal composition for restoring cardiac collaterals according to claim 4 is characterized in that described compositions can be used as capsule, tablet, electuary, powder, the oral liquid formulations form for the treatment of angina pectoris clinically.
CN01131203A 2001-08-31 2001-08-31 Medicinal composition for restoring cardiac collaterals and its application Expired - Lifetime CN1124153C (en)

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CN114177229A (en) * 2021-12-14 2022-03-15 湖南农业大学 Medicine for influencing myocardial cell contraction or relaxation and determination method thereof
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CN115429836B (en) * 2022-08-31 2023-09-12 天津中医药大学第一附属医院 Traditional Chinese medicine preparation for treating arrhythmia
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