CN112370521A - Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery and preparation method and application thereof - Google Patents

Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery and preparation method and application thereof Download PDF

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Publication number
CN112370521A
CN112370521A CN202011548027.6A CN202011548027A CN112370521A CN 112370521 A CN112370521 A CN 112370521A CN 202011548027 A CN202011548027 A CN 202011548027A CN 112370521 A CN112370521 A CN 112370521A
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parts
amino acid
formula
chinese
radix
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CN202011548027.6A
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王福才
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Wuxi Ruinian Juyuantang National Medical Museum Co ltd
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Wuxi Ruinian Juyuantang National Medical Museum Co ltd
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Priority to CN202011548027.6A priority Critical patent/CN112370521A/en
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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Abstract

The invention relates to a Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery and a preparation method and application thereof, the Chinese medicine composition comprises a first formula, a second formula and compound amino acid, the mass ratio of the first formula to the second formula is 50:1, the addition amount of the amino acid is 1-2% of the mass of the first formula and the second formula, the formula in the invention is combined by a classical formula and modern medicines, the addition of the compound amino acid can enhance the immunity of human bodies, the whole formula has better effects on dredging, softening and dilating blood vessels, can play a role in quickly eliminating the soft and hard plaque of the artery wall and enhancing the myocardial contractility, and has better popularization and application prospects.

Description

Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery and preparation method and application thereof
Technical Field
The invention relates to a Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard arterial plaque, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions.
Background
The main reason for the stasis of the heart and cerebral vessels is the soft and hard spots with different sizes formed on the inner wall of the artery vessel. The blood stasis in the blood vessels influences the running of the blood, so that the blood flow is slow, and the blood cannot flow after some blood vessels are blocked by the blood vessels, thereby easily causing cerebral thrombosis. The stasis is a viscous substance, when the stasis is too much and the soft and hard spots formed in the blood vessel wall are thicker, the elasticity of the blood vessel is gradually reduced when the blood vessel is heavier, and when a person is accidentally stimulated, the blood vessel losing the elasticity is easy to block, infarct or crack, and finally, the stroke symptoms such as coronary heart disease, myocardial infarction, cerebral hemorrhage and the like are caused.
In recent years, with the improvement of living standard of people and the aging of population structure, the incidence rate and the fatality rate of cardiovascular and cerebrovascular congestion also show a rapid rising trend, and the incidence age also shows a young trend. It is reported that the death rate of China is about 110 ten thousand per year. Therefore, the traditional Chinese medicine and the western medicine are both hot spots for research in resolving soft and hard spots in blood vessels. However, the efficacy of the traditional Chinese medicine in the classical formula of the traditional Chinese medicine cannot achieve the effect of dissolving soft and hard spots, and the traditional Chinese medicine is too complicated to achieve the obvious effect; in the field of western medicine, although the problems of partial thrombolysis, crown protection and vessel softening can be solved, the effect of eliminating soft and hard spots to a large extent can not be achieved, so that only heart operation can be adopted after the final disease occurs, and the damage to the human body is large.
Disclosure of Invention
The invention aims to solve the problems, develops a Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard arterial plaque, and a preparation method and application thereof, and achieves the purpose of reversing the blood stasis state of the cardiovascular and cerebrovascular system by applying the improved classical traditional Chinese medicine and the biological principle in modern medicine and organically combining combined medication.
The invention adopts the following technical scheme: a Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery comprises a first prescription, a second prescription and compound amino acid, wherein the mass ratio of the first prescription to the second prescription is 50:1, and the addition amount of the compound amino acid is 1-2% of the total mass of the first prescription and the second prescription;
the first formula comprises the following components in parts by weight: 2-5 parts of codonopsis pilosula, 1-3 parts of dried orange peel, 1-2 parts of myrrh, 2-5 parts of radix curcumae, 2-5 parts of mistletoe, 1-2 parts of frankincense, 1-3 parts of divaricate saposhnikovia root, 2-5 parts of salvia miltiorrhiza, 1-2 parts of ground beetle, 1-3 parts of safflower, 2-5 parts of radix achyranthis bidentatae, 2-5 parts of red paeony root, 2-5 parts of ligusticum wallichii, 2-5 parts of radix bupleuri, 2-5 parts of fructus aurantii, 2-5 parts of platycodon grandiflorum, 1-3 parts of liquorice, 2-5 parts of angelica, 2-5 parts of radix rehmanniae, 5-8 parts of astragalus mongholicus, 1-3 parts of earthworm, 1-5 parts of prepared rehmannia root, 1-2 parts of peach kernel, 1-3 parts of pulp of dogwood fruit, 1-2 parts of rhizoma alismatis, 1-3 parts of, 2-5 parts of dipsacus root;
the second formula comprises the following components in parts by weight: 1-2 parts of musk, 3-6 parts of plum slice, 20-40 parts of saffron crocus, 1-3 parts of pearl, 3-6 parts of hippocampus, 15-25 parts of hawthorn total ketone, 3-6 parts of stiff silkworm, 8-12 parts of ginseng, 15-25 parts of dendrobium, 15-25 parts of gastrodia elata, 15-25 parts of pseudo-ginseng and 15-25 parts of American ginseng.
Further, the compound amino acid comprises the following components in parts by weight: 8-10 parts of silkworm pupa amino acid powder, 0.5-1 part of tryptophan, 1-2 parts of arginine, 1-2 parts of taurine, 1-2 parts of three-branched-chain amino acid, 1-2 parts of ornithine and 0.5-1 part of glutamine.
Further, the Chinese and western medicine composition also comprises one or more auxiliary materials which are acceptable in dietetics or pharmacy.
The preparation method of the Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery comprises the following steps:
(1) weighing the components in the first formula according to the weight ratio, preparing codonopsis pilosula, dried orange peel, myrrh, curcuma aromatica, mistletoe, frankincense, divaricate saposhnikovia root, red sage root, ground beetle, safflower, achyranthes bidentata, red peony root, ligusticum wallichii, radix bupleuri, fructus aurantii, platycodon grandiflorum, liquorice, angelica, radix rehmanniae, astragalus mongholicus, earthworm, prepared rehmannia root, peach kernel, dogwood fruit, rhizoma alismatis, Chinese yam, cortex moutan, poria cocos, eucommia ulmoides and dipsacus root into coarse powder, adding 95% alcohol for soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1h with slow fire, filtering to;
(2) weighing musk, plum slice, saffron, pearl, hippocampus, hawthorn total ketone, stiff silkworm, ginseng, dendrobe, gastrodia elata, pseudo-ginseng and American ginseng according to the weight ratio, preparing the components into fine powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, and drying the liquid medicine to obtain fine powder 2;
(3) preparing the compound amino acid according to the weight ratio to obtain fine powder 3.
The Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery is applied and is prepared into water-bindered pills after being uniformly stirred.
The Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery is added with one or more dietetic or pharmaceutically acceptable auxiliary materials and prepared into beverage, oral liquid, granules or tablets according to the conventional process.
In the formula, the sources, the properties and the tastes, the meridian tropism effects and the like of the raw materials are described as follows:
dang Shen is neutral in nature and sweet in flavor. It enters spleen and lung meridians. Tonify middle-jiao and Qi, invigorate spleen and benefit lung. It is indicated for spleen and lung deficiency, shortness of breath, palpitation, poor appetite, loose stool, dyspnea due to deficiency, cough, internal heat, and diabetes.
Tangerine peel, pericarpium Citri Reticulatae is pungent, bitter and warm in nature. Enter spleen and lung meridians, regulate qi and stimulate appetite, dry dampness and resolve phlegm, and treat spleen and stomach diseases.
Mo Yao, neutral in nature, pungent and bitter in flavor. They enter heart, liver and spleen meridians. Dispel stasis, relieve pain, resolve swelling and promote tissue regeneration.
Yu jin has the actions of moving qi and relieving depression, cooling blood and removing blood stasis. It is indicated for pain in chest, abdomen and hypochondrium, mania due to loss of heart, coma due to fever, hematemesis, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, and jaundice.
Parasitic, mild in nature and bitter in taste. Enter liver and kidney meridians, dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, lower blood pressure, prevent abortion and promote lactation.
Frankincense, radix astragali, rhizoma anemarrhenae, radix astragali.
Fang Feng, warm in nature, sweet and pungent in flavor. It enters bladder meridian, liver meridian and spleen meridian, and has the actions of relieving exterior syndrome, dispelling wind-evil and removing dampness.
Salvia miltiorrhiza, bitter in taste and slightly cold in nature, enters pericardium and liver channel, can pass through blood vessels, promote blood circulation to regulate menstruation, has mild drug properties, removes blood stasis to promote tissue regeneration without damaging vital qi, and is a common medicine for promoting blood circulation and regulating menstruation in gynecology.
Eupolyphaga seu Steleophaga, cold in nature, salty in taste, and slightly toxic. Entering liver meridian, breaking blood stasis and reuniting tendons and bones.
Safflower, warm in nature and pungent in flavor. Enter heart and liver meridians, activate blood and dredge meridian, dissipate blood stasis and alleviate pain.
Niu xi is neutral in nature, bitter and sour in taste. Enter liver and kidney meridians, tonify liver and kidney, strengthen tendons and bones, remove blood stasis and dredge meridians, and draw blood downward.
Chi Yao is slightly cold in nature and bitter in taste. Enter liver and spleen meridians, clear heat and cool blood, dissipate blood stasis and relieve pain.
The ligusticum wallichii has the effects of clearing heat and cooling blood, dissipating blood stasis and relieving pain, activating blood and qi, and dispelling wind and relieving pain.
Bupleurum root, radix bupleuri, with slightly cold nature, is bitter in taste. They enter liver, gallbladder and lung meridians, and harmonize exterior and interior, sooth liver and raise yang.
Fructus Aurantii is warm in nature, bitter, pungent and sour in flavor. Enter spleen and stomach meridians, regulate qi to relieve epigastric distention, and remove food stagnation.
Platycodon grandiflorum, mild in nature, bitter and pungent in flavor, enters lung meridian. Dispersing lung qi, eliminating phlegm, relieving sore throat, and expelling pus. Can be used for treating cough with excessive phlegm, fullness and oppression of chest and diaphragm, pharyngalgia, hoarseness, pulmonary abscess, and purulence.
Licorice root, radix Glycyrrhizae is neutral in nature and sweet in taste. Enter heart meridian, stomach meridian, spleen meridian and lung meridian, tonify spleen and qi, relieve cough and eliminate phlegm, relieve spasm and relieve pain, and harmonize property of the medicine.
Dang Gui is warm in nature, sweet and pungent in flavor. Enter liver meridian, heart meridian and spleen meridian, nourish blood and activate blood, regulate menstruation and relieve pain, moisten intestines and relieve constipation.
Sheng Di Huang is cold in nature and sweet in taste. Enter heart, liver and kidney meridians, clear heat and cool blood, nourish yin and promote the production of body fluid.
Huang Qi is sweet in flavor and slightly warm. It enters spleen and lung meridians. Has the functions of invigorating spleen and lung qi, consolidating superficial resistance, and treating exterior deficiency and spontaneous perspiration due to defensive qi deficiency and muscle surface weakness.
Di Long is cold in nature and salty in taste. It enters liver meridian, spleen meridian and bladder meridian, and has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma and promoting urination.
Prepared rehmannia root, radix rehmanniae Praeparata, with slightly warm nature and sweet taste, enters liver and kidney meridians, and has the effects of enriching blood, nourishing yin, replenishing vital essence and replenishing marrow.
Tao ren is bitter and sweet in flavor and neutral in nature. It enters heart, liver and large intestine meridians. Blood stasis dispelling, intestine moistening and constipation relieving. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, traumatic injury, intestinal dryness and constipation.
Dogwood fruit, fructus Corni, being slightly warm in nature and sour and astringent in taste, enters liver and kidney meridians, tonifies liver and kidney, astringes and relieves depletion.
Alisma orientale, rhizoma Alismatis, with cold nature and sweet and bland taste, enters kidney and bladder meridians, induces diuresis and clears away damp-heat.
Yam, neutral in nature and sweet in taste, enters spleen, lung and kidney meridians, tonifies spleen and stomach, promotes the production of body fluid and benefits lung, tonifies kidney and astringes essence
Cortex moutan, being slightly cold in nature, bitter and pungent in taste, enters heart, liver and kidney meridians, clears heat and cools blood, and activates blood circulation to dissipate blood stasis.
Poria cocos, sweet and bland in flavor, mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Du Zhong is warm in nature and sweet in flavor, and enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, and prevent miscarriage.
Chuan Di Huang can nourish liver and kidney, reunite tendons and bones, and regulate blood vessels. It is indicated for soreness of waist and back, weakness of foot and knee, fetal leakage, metrorrhagia, leukorrhagia, spermatorrhea, traumatic injury, incised wound, anal fistula, carbuncle, abscess, sore and swelling.
Saffron, neutral in nature and sweet in taste. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, cooling blood, removing toxic substance, resolving stagnation, and tranquilizing mind.
Pearl is cold in nature, sweet and salty in taste. It enters heart and liver meridians. Tranquilizing, arresting convulsion, improving eyesight, removing nebula, removing toxic substance, and promoting granulation.
Hippocampus, warm in nature, sweet and salty in taste. It enters liver and kidney meridians. Warming kidney, strengthening yang, dissipating nodulation and relieving swelling.
Haw fruit Total Ketone, slightly warm in nature, sour and sweet in taste. It enters spleen, stomach and liver meridians. Promoting digestion, invigorating spleen, promoting qi circulation, and removing blood stasis.
Jiang Can, neutral in nature, salty and pungent in flavor. It enters liver meridian, lung meridian and stomach meridian. Dispel wind, arresting convulsion, resolving phlegm and resolving masses.
Ginseng, radix Ginseng is warm in nature, sweet and slightly bitter in taste. They enter heart, lung, spleen and kidney meridians. Tonify primordial qi, recover pulse to arrest collapse, tonify spleen and lung, promote fluid production and induce tranquilization.
Dendrobe is slightly cold in nature and sweet in taste. It enters stomach meridian and kidney meridian. Benefiting stomach, promoting fluid production, nourishing yin and clearing heat.
Tian Ma is neutral in nature and sweet in flavor. It enters liver meridian. Pacify liver, extinguish wind and stop spasm.
Notoginseng, radix is warm in nature, sweet and slightly bitter in taste. It enters liver meridian and stomach meridian. Dissipating blood stasis, stopping bleeding, relieving swelling and alleviating pain.
American ginseng, cool in nature, sweet in taste and slightly bitter. They enter heart, lung and kidney meridians. Invigorating qi, nourishing yin, clearing away heat, and promoting salivation. Belongs to the field of medicine.
The Borneolum, Borneolum Syntheticum, has effects of dredging orifices, dispelling stagnated fire, removing nebula, clearing eyes, and rapidly relieving swelling, and also has effects of dredging orifices, refreshing mind, clearing heat, promoting diuresis, removing toxic substance, diminishing inflammation, relieving pain, removing necrotic tissue, promoting granulation, dispelling pathogenic wind, relieving cough, and eliminating phlegm. Especially has obvious or special effect on cerebral pain, throat, mouth and teeth non-swelling pain, diffuse bronchitis, scald and the like.
The compound amino acid is composed of a plurality of amino acids required by human body, particularly arginine is an important source for generating nitric oxide in the human body, the nitric oxide generated in the human body can increase the elasticity of blood vessels, expand the blood vessels, and reduce the deposition of soft and hard spots, and in addition, the amino acid can promote the update of the fiber layer of the blood vessel wall and has the functions of softening and keeping the elasticity and toughness of the blood vessel wall.
The Chinese and western medicine composition is convenient to take and carry, waste in the Chinese medicine components is reduced on the basis of ensuring the medicine effect, the immunity can be improved, the blood vessel can be permeated, the aggregation and the attachment of blood platelets are reduced, the deposition of soft and hard arterial plaque on the blood vessel wall is slowed, and the Chinese and western medicine composition has a good market application prospect.
Detailed Description
The present invention will be further described with reference to specific embodiments.
The first embodiment is as follows: preparation of watered pill of Chinese and western medicinal composition
1. Raw materials: the first formula comprises the following components in parts by weight: 2 parts of codonopsis pilosula, 1 part of dried orange peel, 1 part of myrrh, 2 parts of curcuma aromatica, 5 parts of mistletoe, 1 part of frankincense, 3 parts of divaricate saposhnikovia root, 2 parts of salvia miltiorrhiza, 2 parts of ground beetle, 3 parts of safflower, 2 parts of achyranthes bidentata, 2 parts of red peony root, 5 parts of ligusticum chuanxiong hort, 2 parts of radix bupleuri, 5 parts of fructus aurantii, 2 parts of platycodon grandiflorum, 1 part of liquorice, 2 parts of angelica, 2 parts of radix rehmanniae, 8 parts of astragalus membranaceus, 1 part of earthworm, 1 part of prepared rehmannia root, 2 parts of peach kernel, 1 part of pulp of dogwood fruit, 1 part of rhizoma alismatis;
the second formula comprises the following components in parts by weight: 2 parts of musk, 3 parts of sliced plum, 40 parts of saffron, 1 part of pearl, 6 parts of hippocampus, 15 parts of hawthorn total ketone, 6 parts of stiff silkworm, 8 parts of ginseng, 15 parts of dendrobium, 25 parts of gastrodia elata, 15 parts of pseudo-ginseng and 15 parts of American ginseng.
The compound amino acid comprises the following components in parts by weight: 8 parts of silkworm pupa amino acid powder, 1 part of tryptophan, 1 part of arginine, 1 part of taurine, 2 parts of three-branched-chain amino acid, 1 part of ornithine and 0.5 part of glutamine.
2. The preparation method comprises the following steps: (1) weighing the components in the first formula according to the weight ratio, preparing codonopsis pilosula, dried orange peel, myrrh, curcuma aromatica, mistletoe, frankincense, divaricate saposhnikovia root, red sage root, ground beetle, safflower, achyranthes bidentata, red peony root, ligusticum wallichii, radix bupleuri, fructus aurantii, platycodon grandiflorum, liquorice, angelica, radix rehmanniae, astragalus mongholicus, earthworm, prepared rehmannia root, peach kernel, dogwood fruit, rhizoma alismatis, Chinese yam, cortex moutan, poria cocos, eucommia ulmoides and dipsacus root into coarse powder, adding 95% alcohol for soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1h with slow fire, filtering to;
(2) weighing musk, plum slice, saffron, pearl, hippocampus, hawthorn total ketone, stiff silkworm, ginseng, dendrobe, gastrodia elata, pseudo-ginseng and American ginseng according to the weight ratio, preparing the components into fine powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, and drying the liquid medicine to obtain fine powder 2;
(3) preparing the compound amino acid according to the weight ratio to obtain fine powder 3.
3. Pelleting: mixing the three fine powders according to the mass ratio of the first formula to the second formula of 50:1, wherein the addition amount of the compound amino acid is 1% of the total mass of the first formula and the second formula, spreading the mixture in a coating pot, spraying water while rotating the coating pot to enable the fine powders to be completely wet small particles, adding a small amount of fine powders, continuously rolling for a certain time to enable the small particles to be firm and micro-dense, spraying water to scatter the powders, repeatedly performing the operation in such a way to form regular pill molds, selecting pills, drying and packaging into pills.
Example two: preparation of granules of Chinese and western medicine composition
1. Raw materials: the first formula comprises the following components in parts by weight: 3 parts of codonopsis pilosula, 2 parts of dried orange peel, 1 part of myrrh, 3 parts of curcuma aromatica, 3 parts of mistletoe, 1 part of frankincense, 2 parts of divaricate saposhnikovia root, 3 parts of salvia miltiorrhiza, 1 part of ground beetle, 2 parts of safflower, 3 parts of achyranthes bidentata, 3 parts of red peony root, 3 parts of ligusticum chuanxiong hort, 3 parts of radix bupleuri, 3 parts of fructus aurantii, 3 parts of platycodon grandiflorum, 2 parts of liquorice, 3 parts of angelica, 3 parts of radix rehmanniae, 6 parts of astragalus membranaceus, 2 parts of earthworm, 4 parts of prepared rehmannia root, 1 part of peach kernel, 2 parts of pulp of dogwood fruit, 1 part of rhizoma alismatis;
the second formula comprises the following components in parts by weight: 1 part of musk, x pieces, 5 parts of saffron, 20-40 parts of saffron, 2 parts of pearl, 5 parts of hippocampus, 20 parts of hawthorn total ketone, 5 parts of stiff silkworm, 10 parts of ginseng, 20 parts of dendrobium, 20 parts of gastrodia elata, 20 parts of pseudo-ginseng and 20 parts of American ginseng;
compound amino acid: 10 parts of silkworm pupa amino acid powder, 0.5 part of tryptophan, 2 parts of arginine, 2 parts of taurine, 2 parts of three-branched-chain amino acid, 2 parts of ornithine and 1 part of glutamine.
2. The preparation method comprises the following steps: (1) weighing the components in the first formula according to the weight ratio, preparing codonopsis pilosula, dried orange peel, myrrh, curcuma aromatica, mistletoe, frankincense, divaricate saposhnikovia root, red sage root, ground beetle, safflower, achyranthes bidentata, red peony root, ligusticum wallichii, radix bupleuri, fructus aurantii, platycodon grandiflorum, liquorice, angelica, radix rehmanniae, astragalus mongholicus, earthworm, prepared rehmannia root, peach kernel, dogwood fruit, rhizoma alismatis, Chinese yam, cortex moutan, poria cocos, eucommia ulmoides and dipsacus root into coarse powder, adding 95% alcohol for soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1h with slow fire, filtering to;
(2) weighing musk, plum slice, saffron, pearl, hippocampus, hawthorn total ketone, stiff silkworm, ginseng, dendrobe, gastrodia elata, pseudo-ginseng and American ginseng according to the weight ratio, preparing the components into fine powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, and drying the liquid medicine to obtain fine powder 2;
(3) preparing the compound amino acid according to the weight ratio to obtain fine powder 3.
3. Granulating, forming and packaging: mixing the three fine powders according to the mass ratio of the first formula to the second formula of 50:1, wherein the addition amount of the compound amino acid is 1% of the total mass of the first formula and the second formula, adding 40% of sugar powder, boiling, granulating, sieving, and subpackaging to obtain the finished granule.
Example three: preparation of chewable tablet of Chinese and western medicinal composition
1. Raw materials: the first formula comprises the following components in parts by weight: 5 parts of codonopsis pilosula, 3 parts of dried orange peel, 2 parts of myrrh, 5 parts of curcuma aromatica, 2 parts of mistletoe, 2 parts of frankincense, 1 part of divaricate saposhnikovia root, 5 parts of salvia miltiorrhiza, 1 part of ground beetle, 1 part of safflower, 5 parts of achyranthes bidentata, 5 parts of red paeony root, 2 parts of ligusticum chuanxiong hort, 5 parts of radix bupleuri, 2 parts of fructus aurantii, 5 parts of platycodon grandiflorum, 3 parts of liquorice, 5 parts of angelica, 5 parts of radix rehmanniae, 5 parts of astragalus membranaceus, 3 parts of earthworm, 5 parts of prepared rehmannia root, 1 part of peach kernel, 3 parts of pulp of dogwood fruit, 2 parts of rhizoma alismatis;
the second formula comprises the following components in parts by weight: 1 part of musk, 6 parts of plum slice, 20 parts of saffron, 3 parts of pearl, 3 parts of sea horse, 25 parts of hawthorn total ketone, 3 parts of stiff silkworm, 12 parts of ginseng, 15 parts of dendrobium, 15 parts of gastrodia elata, 25 parts of pseudo-ginseng and 25 parts of American ginseng.
The compound amino acid comprises the following components in parts by weight: 10 parts of silkworm pupa amino acid powder, 0.5 part of tryptophan, 1 part of arginine, 2 parts of taurine, 1 part of three-branched-chain amino acid, 2 parts of ornithine and 1 part of glutamine.
2. The preparation method comprises the following steps: (1) weighing the components in the first formula according to the weight ratio, preparing codonopsis pilosula, dried orange peel, myrrh, curcuma aromatica, mistletoe, frankincense, divaricate saposhnikovia root, red sage root, ground beetle, safflower, achyranthes bidentata, red peony root, ligusticum wallichii, radix bupleuri, fructus aurantii, platycodon grandiflorum, liquorice, angelica, radix rehmanniae, astragalus mongholicus, earthworm, prepared rehmannia root, peach kernel, dogwood fruit, rhizoma alismatis, Chinese yam, cortex moutan, poria cocos, eucommia ulmoides and dipsacus root into coarse powder, adding 95% alcohol for soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1h with slow fire, filtering to;
(2) weighing musk, plum slice, saffron, pearl, hippocampus, hawthorn total ketone, stiff silkworm, ginseng, dendrobe, gastrodia elata, pseudo-ginseng and American ginseng according to the weight ratio, preparing the components into fine powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, and drying the liquid medicine to obtain fine powder 2;
(3) preparing the compound amino acid according to the weight ratio to obtain fine powder 3.
3. And (3) granulating: mixing the three fine powders according to the mass ratio of the first formula to the second formula of 50:1, wherein the addition amount of the compound amino acid is 1% of the total mass of the first formula and the second formula, adding 30% of sugar powder, 10% of pregelatinized starch and 0.1% of aspartame, boiling, granulating, and sieving to obtain granules;
4. tabletting and subpackaging: adding 1.5% of superfine silica gel powder into the granules, tabletting and subpackaging to obtain finished tablets.

Claims (6)

1. A Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery is characterized in that: the Chinese and western medicine composition comprises a first prescription, a second prescription and compound amino acid, wherein the mass ratio of the first prescription to the second prescription is 50:1, and the addition amount of the compound amino acid is 1-2% of the total mass of the first prescription and the second prescription;
the first formula comprises the following components in parts by weight: 2-5 parts of codonopsis pilosula, 1-3 parts of dried orange peel, 1-2 parts of myrrh, 2-5 parts of radix curcumae, 2-5 parts of mistletoe, 1-2 parts of frankincense, 1-3 parts of divaricate saposhnikovia root, 2-5 parts of salvia miltiorrhiza, 1-2 parts of ground beetle, 1-3 parts of safflower, 2-5 parts of radix achyranthis bidentatae, 2-5 parts of red paeony root, 2-5 parts of ligusticum wallichii, 2-5 parts of radix bupleuri, 2-5 parts of fructus aurantii, 2-5 parts of platycodon grandiflorum, 1-3 parts of liquorice, 2-5 parts of angelica, 2-5 parts of radix rehmanniae, 5-8 parts of astragalus mongholicus, 1-3 parts of earthworm, 1-5 parts of prepared rehmannia root, 1-2 parts of peach kernel, 1-3 parts of pulp of dogwood fruit, 1-2 parts of rhizoma alismatis, 1-3 parts of, 2-5 parts of dipsacus root;
the second formula comprises the following components in parts by weight: 1-2 parts of musk, 3-6 parts of plum slice, 20-40 parts of saffron crocus, 1-3 parts of pearl, 3-6 parts of hippocampus, 15-25 parts of hawthorn total ketone, 3-6 parts of stiff silkworm, 8-12 parts of ginseng, 15-25 parts of dendrobium, 15-25 parts of gastrodia elata, 15-25 parts of pseudo-ginseng and 15-25 parts of American ginseng.
2. The pharmaceutical composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque in artery according to claim 1, wherein: the compound amino acid comprises the following components in parts by weight: 8-10 parts of silkworm pupa amino acid powder, 0.5-1 part of tryptophan, 1-2 parts of arginine, 1-2 parts of taurine, 1-2 parts of three-branched-chain amino acid, 1-2 parts of ornithine and 0.5-1 part of glutamine.
3. The pharmaceutical composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque in artery according to claim 1, wherein: the Chinese and western medicine composition also comprises one or more auxiliary materials which are acceptable in dietetics or pharmacy.
4. A preparation method of a Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery is characterized in that: the method comprises the following steps:
(1) weighing 2-5 parts of codonopsis pilosula, 1-3 parts of dried orange peel, 1-2 parts of myrrh, 2-5 parts of radix curcumae, 2-5 parts of parasitic loranthus, 1-2 parts of frankincense, 1-3 parts of radix sileris, 2-5 parts of salvia miltiorrhiza, 1-2 parts of ground beetle, 1-3 parts of safflower, 2-5 parts of radix achyranthis bidentatae, 2-5 parts of radix paeoniae rubra, 2-5 parts of ligusticum chuanxiong hort, 2-5 parts of radix bupleuri, 2-5 parts of fructus aurantii, 2-5 parts of platycodon grandiflorum, 1-3 parts of liquorice, 2-5 parts of angelica, 2-5 parts of radix rehmanniae, 5-8 parts of astragalus membranaceus, 1-3 parts of earthworm, 1-5 parts of prepared rehmannia root, 1-2 parts of peach kernel, 1-3 parts of cornus pulp, 1-2 parts of rhizoma alismatis, 1-, 1-2 parts of poria cocos, 2-5 parts of eucommia ulmoides and 2-5 parts of dipsacus root, preparing all the components into coarse powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, filtering to obtain a liquid medicine, drying and concentrating to obtain fine powder 1;
(2) weighing 1-2 parts of musk, 3-6 parts of sliced plum, 20-40 parts of saffron, 1-3 parts of pearl, 3-6 parts of sea horse, 15-25 parts of hawthorn total ketone, 3-6 parts of stiff silkworm, 8-12 parts of ginseng, 15-25 parts of dendrobe, 15-25 parts of gastrodia elata, 15-25 parts of pseudo-ginseng and 15-25 parts of American ginseng according to the weight ratio, preparing the components into fine powder, adding 95% alcohol, soaking for 15 days, adding purified water with the volume of 20% of the alcohol, decocting for 1 hour with slow fire, and drying the liquid medicine to obtain fine powder 2;
(3) mixing the fine powder 1 and the fine powder 2 according to a mass ratio of 50:1, and preparing the compound amino acid according to a weight ratio, wherein the addition amount of the compound amino acid is 1-2% of the total mass of the fine powder 1 and the fine powder 2, so as to obtain fine powder 3.
5. The use of the pharmaceutical composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque in arteries of claim 1, wherein: stirring and making into watered pill.
6. The use of a pharmaceutical composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque in arteries according to claim 1, wherein the pharmaceutical composition comprises: adding one or more of dietetic or pharmaceutically acceptable adjuvants, and making into beverage, oral liquid, granule or tablet by conventional method.
CN202011548027.6A 2020-12-24 2020-12-24 Chinese and western medicine composition for promoting blood circulation to remove blood stasis and eliminating soft and hard plaque of artery and preparation method and application thereof Pending CN112370521A (en)

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