CN102631655B - Medicine for treating coronary heart disease and preparation method for medicine - Google Patents
Medicine for treating coronary heart disease and preparation method for medicine Download PDFInfo
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Abstract
The invention discloses a medicine for treating a coronary heart disease and a preparation method for the medicine. The medicine is mainly prepared by dangshen, medical stones, radix curcumae, radix astragali, safflower carthamus, Chinese angelica, immature bitter orange, bamboo shavings, glossy ganoderma, corydalis tuber, rhizoma ligustici wallichii, mistletoe, cassia seeds, lignum dalbergiae odoriferae, allium macrostemon bunge, epimedium, fleece-flower roots, fushen, cinnabar and white mustard by weight. The medicine has functions of relieving chest stuffiness and regulating vital energy, promoting blood circulation to remove blood stasis, activating meridians to stop pain, benefiting vital energy and nourishing heart and recuperating intestines and stomach, is used for treating the coronary heart disease, is short in treatment course and free of toxic and side effects, and takes effects fast. The coronary heart disease does not have a relapse after curing.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Coronary heart disease is a kind of modal heart disease, refers to the myocardial dysfunction and the organic disease that cause because of coronary stricture, blood supply insufficiency, so claim again ischemic heart desease.A kind of pain of squeezing property occurs in Symptoms thoracic cavity central authorities, and can delay to neck, chin, arm, back and stomach.Other of outbreak may symptoms have dizzy, tachypnea, perspire, shiver, feel sick and faint.Severe patient may the death because of heart failure.At present, western medicine coronary heart disease poor effect, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of effective treatment coronary heart disease.
Summary of the invention
The inventor has finally found the Chinese medicine of effective treatment coronary heart disease, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of Chinese medicine composition that can effectively treat coronary heart disease.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Codonopsis, Maifanitum, Radix Curcumae, the Radix Astragali, Flos Carthami, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Ganoderma lucidum seu Japonicum, Rhizoma Corydalis, Rhizoma Chuanxiong, Herba Taxilli, Semen Cassiae, Lignum Dalbergiae Odoriferae, Bulbus Allii Macrostemonis, Herba Epimedii, Radix Polygoni Multiflori, Poria cum Radix Pini, Radix Aristolochiae Kaempferi, Herba Asari, Radix Notoginseng, Rhizoma Zingiberis, succinum, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Angelicae Pubescentis, Radix Asparagi, Herba Leonuri, Radix Aconiti Lateralis Preparata, Caulis Spatholobi, Semen Trichosanthis, Fructus Jujubae, Radix Glycyrrhizae, Semen Sinapis Albae medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can fast treating coronary disease palindromia.Wherein select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Maifanitum to be because its nature and flavor are sweet, temperature is returned liver, kidney, stomach warp, detoxicating and resolving stagnation of pathogens is arranged, removing the necrotic tissue and promoting granulation, dry the liver benefiting stomach invigorating, blood circulation promoting and blood stasis dispelling, diuresis fossil, the function of life lengthening except cold, control the carbuncle carbuncle on the back, acne, eczema, beriberi, toothache, oral ulcer, rheumatism arthromyodynia, lumbago and backache, the Chronic Liver sclerosis is scorching, gastritis, diabetes, neurasthenia, wound is red and swollen, hypertension, tumor, lithangiuria.Select Radix Curcumae to be because its nature and flavor are arduous, cold enters the heart, lung, Liver Channel, have the circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs is controlled all pains of breast abdomen side of body rib, it is demented to lose the heart, the calentura coma is spitted blood epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select the Radix Astragali, the different name Radix Astragali, its nature and flavor are sweet, and tepor enters lung, spleen channel, gives birth to the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Flos Carthami to be because its nature and flavor are hot, temperature enters the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, dispelling the stagnated QI is arranged, loose painful abdominal mass is rushed down expectorant, and the function of removing food stagnancy is controlled chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cold enters stomach, gallbladder meridian, and heat clearing away is arranged, and removing heat from blood reduces phlegm, and the function of emesis is controlled dysphoria with smothery sensation vomiting, singultus, and the expectorant heat syndrome cough is breathed heavily, and spits blood epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select Ganoderma lucidum seu Japonicum to be because its nature and flavor are sweet, flat, control asthenia, cough, asthma, insomnia, dyspepsia.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis is regulated the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature enters liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Herba Taxilli to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, invigorating the liver and kidney is arranged, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function is controlled soreness of waist and knee joint, and is hemiplegia a little less than the muscles and bones flaccidity, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Selecting Semen Cassiae is that cold enters liver, kidney channel, and liver heat removing is arranged because of its property bitter but sweet flavor, make eye bright, and diuretic, the function of relieving constipation is controlled the wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, liver cirrhosis abdomen, habitual constipation.Select Lignum Dalbergiae Odoriferae to be because its nature and flavor are hot, temperature enters liver, spleen channel, regulate the flow of vital energy, and hemostasis, clots absorbing, the function of analgesic therapy is controlled haematemesis, spitting of blood, incised wound is hemorrhage, traumatic injury, the carbuncle skin ulcer is swollen, lumbago, skelalgia of rheumatism, heart peratodynia.Select Bulbus Allii Macrostemonis to be because its nature and flavor are arduous, temperature enters meridian of Hand-YANG MING, regulates the flow of vital energy, and the chest stuffiness relieving activates yang, and the function of eliminating stagnation is controlled the thorough back of the body of obstruction of qi in the chest and cardialgia, and the gastral cavity painful abdominal mass is not relaxed, and retches, and is heavy behind the dysentery, furuncle.Selecting Herba Epimedii is that temperature enters liver, kidney channel, and kidney invigorating and YANG supporting is arranged because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled the sexual impotence erectile problem, dribbling urination, and the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Radix Polygoni Multiflori to be because its property bitter but sweet flavor is puckery, tepor enters liver, kidney channel, and tonifying liver is arranged, and kidney tonifying nourishes blood, the function of dispeling the wind, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and the waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Poria cum Radix Pini to be because its property slightly sweet flavor is flat, enter the heart, spleen channel, mind calming is arranged, calm the nerves, the function of diuretic is controlled the palpitation with fear of having a guilty conscience, and is forgetful, insomnia, frightened Epilepsy, dysuria.Select Radix Aristolochiae Kaempferi to be because its nature and flavor toil is cold in nature, nontoxic, enter the heart, lung, Liver Channel, the detumescence of relieving inflammation or internal heat, loose blood and relieving pain, the function that antidotes against snake bite is controlled red-white dysentery, breast, abdomen, laryngalgia, venom.Select Herba Asari to be because its nature and flavor are hot, temperature enters lung, kidney channel, dispel the wind, and cold expelling, row water is opened the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Selecting Radix Notoginseng is that temperature enters liver, stomach, large intestine channel, and hemostasis is arranged because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy is controlled haematemesis, hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain.Select Rhizoma Zingiberis to be because its nature and flavor are hot, heat enters spleen, stomach, lung meridian, and there have warming middle-JIAO to pursue to be cold, and the function that recuperating depleted YANG is promoted blood circulation is controlled trusted subordinate's cold type of pain, vomit and diarrhoea, and the cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Select succinum to be because its nature and flavor are sweet, flat, enter the heart, liver, small intestine meridian, tranquillizing the mind by relieving convulsion is arranged, the dissipating blood stasis hemostasis, the function of relieving stranguria by diuresis is controlled the infantile convulsion epilepsy, the palpitation with fear insomnia, the stranguria with blood hematuria, urinary obstruction, women's amenorrhea stops the stasis of blood stomachache puerperal, skin sore, traumatic injuries.Selecting Ramulus Cinnamomi is that temperature enters bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature enters kidney, urinary bladder channel, dispels the wind, and win and wet, cold expelling, the function of pain relieving is controlled anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, YIN nourishing is arranged, moisturize, lung heat clearing, the function of pathogenic fire reducing is controlled fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain is quenched one's thirst, constipation.Select Herba Leonuri to be because its nature and flavor are arduous, cold enters pericardium, Liver Channel, invigorate blood circulation, and blood stasis dispelling, regulating menstruation, the function of the water that disappears is controlled menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria is rushed down blood, the carbuncle skin infection.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature enters the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Semen Trichosanthis to be because its nature and flavor are sweet, cold, return lung, stomach, large intestine channel, moistening the lung and resolving phlegm is arranged, the function of laxation relieving constipation, it is glutinous to control cough caused by dryness expectorant, the dryness of the intestine constipation.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature enters spleen, stomach warp, and the spleen reinforcing stomach function regulating is arranged, and supplementing QI for promoting the production of body fluid transfers battalion to defend, and separates the function of poison of drug, controls the insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Semen Sinapis Albae to be because its nature and flavor are hot, temperature enters lung, stomach warp, and the promoting the circulation of QI eliminating phlegm is arranged, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain is controlled the phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, the regurgitation vomiting, aphasia due to apoplexy, the limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope:
Radix Codonopsis 8-12 gram Maifanitums 6-10 gram Radix Curcumaes 6-10 grams
The Radix Astragali 6-10 gram Flos Carthamis 6-10 gram Radix Angelicae Sinensis 6-10 grams
Fructus Aurantii Immaturus 5-15 gram Caulis Bambusae In Taenia 5-15 kairine Ganoderma lucidum seu Japonicum 5-15 grams
Rhizoma Corydalis 15-25 gram Rhizoma Chuanxiongs 15-25 gram Herba Taxillis 15-25 grams
Semen Cassiae 6-10 gram Lignum Dalbergiae Odoriferaes 6-10 gram Bulbus Allii Macrostemonis 6-10 grams
Herba Epimedii 3-7 gram Radix Polygoni Multiflori 3-7 gram Poria cum Radix Pinis 3-7 grams
Radix Aristolochiae Kaempferi 6-10 gram Herba Asaris 3-7 gram Radix Notoginseng 6-10 grams
Rhizoma Zingiberis 5-15 gram succinums 5-15 gram Ramulus Cinnamomi 8-12 grams
Radix Salviae Miltiorrhizae 8-12 gram Radix Angelicae Pubescentiss 8-12 gram Radix Asparagi 3-7 grams
Herba Leonuri 5-15 gram Radix Aconiti Lateralis Preparatas 5-15 gram Caulis Spatholobis 3-7 grams
Semen Trichosanthis 6-10 gram Fructus Jujubaes 6-10 gram Radix Glycyrrhizaes 5-15 grams
Semen Sinapis Albae 6-10 grams.
Preferable amount is:
Radix Codonopsis 10 gram Maifanitums 8 gram Radix Curcumaes 8 grams
The Radix Astragali 8 gram Flos Carthamis 8 gram Radix Angelicae Sinensis 8 grams
Fructus Aurantii Immaturus 10 gram Caulis Bambusae In Taenia 10 kairine Ganoderma lucidum seu Japonicum 10 grams
Rhizoma Corydalis 20 gram Rhizoma Chuanxiongs 20 gram Herba Taxillis 20 grams
Semen Cassiae 8 gram Lignum Dalbergiae Odoriferaes 8 gram Bulbus Allii Macrostemonis 8 grams
Herba Epimedii 5 gram Radix Polygoni Multiflori 5 gram Poria cum Radix Pinis 5 grams
Radix Aristolochiae Kaempferi 8 gram Herba Asaris 5 gram Radix Notoginseng 8 grams
Rhizoma Zingiberis 10 gram succinums 10 gram Ramulus Cinnamomi 10 grams
Radix Salviae Miltiorrhizae 10 gram Radix Angelicae Pubescentiss 10 gram Radix Asparagi 5 grams
Herba Leonuri 10 gram Radix Aconiti Lateralis Preparatas 10 gram Caulis Spatholobis 5 grams
Semen Trichosanthis 8 gram Fructus Jujubaes 8 gram Radix Glycyrrhizaes 10 grams
Semen Sinapis Albae 8 grams.
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
2, Maifanitum: remove impurity, cleaning, drying break into fragment;
3, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section is dried;
4, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
5, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
6, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
7, Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section is dried;
8, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shake off the ash bits, rub Cheng Xiaotuan or cutting;
9, Ganoderma lucidum seu Japonicum: remove impurity, clean, moisten softly, cut sheet, drying is sieved and is removed chip;
10, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
11, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
12, Herba Taxilli: wash, run through, cutting is dried;
13, Semen Cassiae: get clean Semen Cassiae, put and fry extremely little fragrance that has in the pot, take out, cool;
14, Lignum Dalbergiae Odoriferae: after the water logging, steam to appropriateness, pound sheet or flaking dry;
15, Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
16, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
17, Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice dry;
18, Poria cum Radix Pini: former medicine is removed impurity, sieve dedust bits.
19, Radix Aristolochiae Kaempferi: get crude drug, remove residual stem and fibrous root, clean and dry.
20, Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
21, Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;
22, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
23, succinum: choose clean impurity, the time spent smashs to pieces and is ground into fine powder;
24, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;
25, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
26, Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through rear section, drying;
27, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;
28, Herba Leonuri: choose decontamination, clean, run through, cutting is dried;
29, Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section is dried;
30, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;
31, Semen Trichosanthis: get crude drug, remove shrivelled seed, impurity, the time spent smashs to pieces;
32, Fructus Jujubae: choose clean impurity, dry;
33, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry.
34, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product.
Two, preparation
1, Radix Codonopsis with described weight, Maifanitum, Radix Curcumae, the Radix Astragali, Flos Carthami, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Ganoderma lucidum seu Japonicum, Rhizoma Corydalis, Rhizoma Chuanxiong, Herba Taxilli, Semen Cassiae, Lignum Dalbergiae Odoriferae, Bulbus Allii Macrostemonis, Herba Epimedii, Radix Polygoni Multiflori, Poria cum Radix Pini, Radix Aristolochiae Kaempferi, Herba Asari, Radix Notoginseng, Rhizoma Zingiberis, succinum, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Angelicae Pubescentis, Radix Asparagi, Herba Leonuri, Radix Aconiti Lateralis Preparata, Caulis Spatholobi, Semen Trichosanthis, Fructus Jujubae, Radix Glycyrrhizae, the Semen Sinapis Albae medicine decocts with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 20 minutes, namely got for the first time decoction liquor in 15 minutes with slow fire boiling again, decoction liquor is poured in the container for the first time.
2, the medicinal residues after for the first time filtration add 2 times of amounts of water, boil with high heat first, use slow fire boiling 20 minutes again, and decoction liquor is poured in the container for the second time.
3, twice decoction liquor carried out mixing and stirring, used again slow fire boiling 20 minutes, be divided into 4 doses and take.
Medicine of the present invention has that the chest stuffiness relieving is regulated the flow of vital energy, the function of blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, Qi-benefiting and heart-nourishing, the intestines and stomach coordinating, is used for the treatment of coronary heart disease, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.4kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day three times, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy coronary heart disease of the present invention:
1, physical data
Accept out-patient's totally 200 examples for medical treatment, early stage patient 150 examples wherein, middle late patient's 50 examples.
2, diagnostic criteria
The coronary heart disease early symptom:
(1) when fatigue or psychentonia, show as breastbone after or precordial fullness pain, or tighten sample pain, and shoulder, left upper arm radiation left, continue 3-5 minute, spontaneous remission after having a rest.
(2) early symptom of coronary heart disease when physical exertion, have nervous, breathe hard, fatigue and dyspnea sense.
(3) heavy meal, can feel cardiopalmus, chest pain when cold.
(4) in public places or in the meeting-place, or when climbing the mountain, before own, feel that than others is easy uncomfortable in chest, cardiopalmus, hypopnea and air are inadequate especially upstairs.
When (5) night, sleep pillow was low, feel to feel suffocated, need the high pillow clinostatism; Sleep soundly or the nightmare process in wake up with a start suddenly, feel cardiopalmus, uncomfortable in chest, hypopnea, need to sit up and just take a turn for the better afterwards.
(6) hear that the sound of drums and gongs or other noises on every side just causes nervous, uncomfortable in chest.
(7) headache, toothache, the skelalgia relevant with motion appear.
(8) early symptom of coronary heart disease also shows as the left shoulder pain of long-term outbreak, does not repeatedly heal through general treatment.
Coronary heart disease to middle and advanced stage except above sx↑, repeatedly occur pulse uneven, overrun or excessively slow.
3, Therapeutic Method
Select above-mentioned medicament, take to the patient, early stage patient is each serving with 1 dose, and every day early, respectively take 1 evening, and 20 days is a course for the treatment of, takes continuously 2 courses for the treatment of.The middle and advanced stage patient is each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 20 days is a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: clinical symptom disappearance after the treatment, body constitution recover normal, observe half a year without the recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;
Invalid: clinical partial symptoms disappears or without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy patients with coronary heart disease 200 examples of the present invention, early stage patient 150 examples wherein, produce effects 145 examples as a result, obvious effective rate is 96.67%, 4 examples that take a turn for the better, improvement rate is 2.67%, invalid 1 example, total effective rate is 99.34%.Middle and advanced stage patient 50 examples, produce effects 42 examples as a result, obvious effective rate is 84%, 5 examples that take a turn for the better, improvement rate is 10%, invalid 3 examples, total effective rate is 94%.
Claims (3)
1. medicine for the treatment of coronary heart disease, it is characterized in that: it is to be made by the crude drug in the following weight range:
Radix Codonopsis 8-12 gram Maifanitums 6-10 gram Radix Curcumaes 6-10 grams
The Radix Astragali 6-10 gram Flos Carthamis 6-10 gram Radix Angelicae Sinensis 6-10 grams
Fructus Aurantii Immaturus 5-15 gram Caulis Bambusae In Taenia 5-15 kairine Ganoderma lucidum seu Japonicum 5-15 grams
Rhizoma Corydalis 15-25 gram Rhizoma Chuanxiongs 15-25 gram Herba Taxillis 15-25 grams
Semen Cassiae 6-10 gram Lignum Dalbergiae Odoriferaes 6-10 gram Bulbus Allii Macrostemonis 6-10 grams
Herba Epimedii 3-7 gram Radix Polygoni Multiflori 3-7 gram Poria cum Radix Pinis 3-7 grams
Radix Aristolochiae Kaempferi 6-10 gram Herba Asaris 3-7 gram Radix Notoginseng 6-10 grams
Rhizoma Zingiberis 5-15 gram succinums 5-15 gram Ramulus Cinnamomi 8-12 grams
Radix Salviae Miltiorrhizae 8-12 gram Radix Angelicae Pubescentiss 8-12 gram Radix Asparagi 3-7 grams
Herba Leonuri 5-15 gram Radix Aconiti Lateralis Preparatas 5-15 gram Caulis Spatholobis 3-7 grams
Semen Trichosanthis 6-10 gram Fructus Jujubaes 6-10 gram Radix Glycyrrhizaes 5-15 grams
Semen Sinapis Albae 6-10 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Codonopsis 10 gram Maifanitums 8 gram Radix Curcumaes 8 grams
The Radix Astragali 8 gram Flos Carthamis 8 gram Radix Angelicae Sinensis 8 grams
Fructus Aurantii Immaturus 10 gram Caulis Bambusae In Taenia 10 kairine Ganoderma lucidum seu Japonicum 10 grams
Rhizoma Corydalis 20 gram Rhizoma Chuanxiongs 20 gram Herba Taxillis 20 grams
Semen Cassiae 8 gram Lignum Dalbergiae Odoriferaes 8 gram Bulbus Allii Macrostemonis 8 grams
Herba Epimedii 5 gram Radix Polygoni Multiflori 5 gram Poria cum Radix Pinis 5 grams
Radix Aristolochiae Kaempferi 8 gram Herba Asaris 5 gram Radix Notoginseng 8 grams
Rhizoma Zingiberis 10 gram succinums 10 gram Ramulus Cinnamomi 10 grams
Radix Salviae Miltiorrhizae 10 gram Radix Angelicae Pubescentiss 10 gram Radix Asparagi 5 grams
Herba Leonuri 10 gram Radix Aconiti Lateralis Preparatas 10 gram Caulis Spatholobis 5 grams
Semen Trichosanthis 8 gram Fructus Jujubaes 8 gram Radix Glycyrrhizaes 10 grams
Semen Sinapis Albae 8 grams.
3. the preparation method of described medicine according to claim 1, it comprises the following steps:
(1) gets the raw materials ready
(1) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
(2) Maifanitum: remove impurity, cleaning, drying break into fragment;
(3) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section is dried;
(4) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(5) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(6) Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(7) Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section is dried;
(8) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shake off the ash bits, rub Cheng Xiaotuan or cutting;
(9) Ganoderma lucidum seu Japonicum: remove impurity, clean, moisten softly, cut sheet, drying is sieved and is removed chip;
(10) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(11) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(12) Herba Taxilli: wash, run through, cutting is dried;
(13) Semen Cassiae: get clean Semen Cassiae, put and fry extremely little fragrance that has in the pot, take out, cool;
(14) Lignum Dalbergiae Odoriferae: after the water logging, steam to appropriateness, pound sheet or flaking dry;
(15) Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
(16) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
(17) Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice dry;
(18) Poria cum Radix Pini: former medicine is removed impurity, sieve dedust bits;
(19) Radix Aristolochiae Kaempferi: get crude drug, remove residual stem and fibrous root, clean and dry;
(20) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
(21) Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;
(22) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
(23) succinum: choose clean impurity, the time spent smashs to pieces and is ground into fine powder;
(24) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;
(25) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(26) Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through rear section, drying;
(27) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;
(28) Herba Leonuri: choose decontamination, clean, run through, cutting is dried;
(29) Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section is dried;
(30) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;
(31) Semen Trichosanthis: get crude drug, remove shrivelled seed, impurity, the time spent smashs to pieces;
(32) Fructus Jujubae: choose clean impurity, dry;
(33) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
(34) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product;
(2) preparation
(1) with the Radix Codonopsis of described weight, Maifanitum, Radix Curcumae, the Radix Astragali, Flos Carthami, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Ganoderma lucidum seu Japonicum, Rhizoma Corydalis, Rhizoma Chuanxiong, Herba Taxilli, Semen Cassiae, Lignum Dalbergiae Odoriferae, Bulbus Allii Macrostemonis, Herba Epimedii, Radix Polygoni Multiflori, Poria cum Radix Pini, Radix Aristolochiae Kaempferi, Herba Asari, Radix Notoginseng, Rhizoma Zingiberis, succinum, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Angelicae Pubescentis, Radix Asparagi, Herba Leonuri, Radix Aconiti Lateralis Preparata, Caulis Spatholobi, Semen Trichosanthis, Fructus Jujubae, Radix Glycyrrhizae, the Semen Sinapis Albae medicine decocts with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 20 minutes, namely got for the first time decoction liquor in 15 minutes with slow fire boiling again, decoction liquor is poured in the container for the first time;
(2) medicinal residues after for the first time filtration add 2 times of amounts of water, boil with high heat first, use slow fire boiling 20 minutes again, and decoction liquor is poured in the container for the second time;
(3) twice decoction liquor carried out mixing and stirring, used again slow fire boiling 20 minutes, be divided into 4 doses.
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| CN103071115B (en) * | 2013-01-06 | 2014-06-25 | 陈明荣 | Traditional Chinese medicine preparation for treating coronary sclerosis |
| CN103638462A (en) * | 2013-12-05 | 2014-03-19 | 青岛友铭辰生物技术有限公司 | Chinese medicinal liquor for treating coronary heart disease and preparation method thereof |
| CN103784690B (en) * | 2014-02-27 | 2016-03-30 | 蒋佩瑄 | One treats cardiopathic Chinese medicine composition |
| CN105456710B (en) * | 2016-01-07 | 2017-11-21 | 孟寒 | A kind of blood activating and fat reducing medicine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101062263A (en) * | 2007-05-18 | 2007-10-31 | 杨庆朝 | Medicine for treating coronary heart disease |
| CN101181600A (en) * | 2007-11-20 | 2008-05-21 | 王振才 | Traditional chinese medicine composition for curing cardiovascular and cerebrovascular diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101062263A (en) * | 2007-05-18 | 2007-10-31 | 杨庆朝 | Medicine for treating coronary heart disease |
| CN101181600A (en) * | 2007-11-20 | 2008-05-21 | 王振才 | Traditional chinese medicine composition for curing cardiovascular and cerebrovascular diseases |
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