CN110638955A

CN110638955A - Chinese medicinal composition for treating arthralgia

Info

Publication number: CN110638955A
Application number: CN201910998806.7A
Authority: CN
Inventors: 贺君; 杨培丹; 李婷
Original assignee: First Affiliated Hospital of Guangzhou University of Chinese Medicine
Current assignee: First Affiliated Hospital of Guangzhou University of Chinese Medicine
Priority date: 2019-10-21
Filing date: 2019-10-21
Publication date: 2020-01-03

Abstract

The invention discloses a traditional Chinese medicine composition for treating arthralgia, which comprises raw material medicines of notopterygium root, large-leaved gentian, divaricate saposhnikovia root, kudzuvine root, Chinese thorowax root, vinegar-processed nutgrass galingale rhizome, Chinese angelica, red paeony root, szechuan lovage rhizome, membranous milkvetch root, pilose asiabell root, largehead atractylodes rhizome, coix seed, largehead atractylodes rhizome, tangerine peel, rhizoma pinellinae praeparata, safflower, blanched peach seed. The Chinese herbal medicine has the characteristics of wide source, low cost, easy preparation and remarkable treatment effect; the prescription does not contain medicinal materials with larger toxic and side effects such as tripterygium wilfordii, nux vomica and the like, and has small stimulation to gastrointestinal tracts after long-term use; starts from two aspects of replenishing qi and blood and promoting blood circulation to remove blood stasis, can improve the immunity of the human body and prevent the bone destruction. Has unique curative effect on rheumatic arthritis, compression fracture, scapulohumeral periarthritis and limb pain after stroke which belong to qi deficiency and blood stasis type or liver and kidney deficiency type according to syndrome differentiation, has no obvious adverse reaction, and is suitable for popularization and application.

Description

Chinese medicinal composition for treating arthralgia

Technical Field

The invention relates to a traditional Chinese medicine composition for treating arthralgia, in particular to a traditional Chinese medicine composition for treating arthralgia caused by qi deficiency and blood stasis or liver and kidney deficiency, such as rheumatic arthritis, compression fracture, scapulohumeral periarthritis, post-stroke limb pain and the like according to traditional Chinese medicine differentiation.

Background

The arthralgia syndrome has a wide range, and can comprise various muscle and joint pain diseases such as rheumatoid arthritis, gout, scapulohumeral periarthritis, tenosynovitis, fibrositis, bony spur, compression fracture and the like in modern medicine. The theory of traditional Chinese medicine considers that: after the human body suffers from wind, cold, dampness and evil, the circulation of qi and blood is not smooth, which causes the symptoms of aching pain, numbness, heavy weight, difficult flexion or swollen joints of muscles and joints, and the traditional Chinese medicine is generally called arthralgia. Arthralgia syndrome is a common chronic disease, and is more related to patients.

In the case of rheumatic arthritis, the rheumatic arthritis is manifested by joint pain and movement disorder, and if the treatment is not performed in time, the heart can be seriously injured, so that heart valves are adhered, scars are formed, and finally, the chronic rheumatic heart disease is developed. Research shows that the total incidence rate of the rheumatoid arthritis in people can reach 9.56 percent, the incidence rate of the rheumatoid arthritis in old people is higher than 50 percent and is far higher than the incidence rate of the rheumatoid arthritis by 3 percent. Once a patient with compression fracture fractures, the probability of fracture again is increased, and in addition, the vertebral column deformity also causes the chest and abdomen to be pressed to influence respiration and appetite and also causes the sleep quality to be reduced, so that the vicious circle causes various complications. The incidence of osteoporotic vertebral compression fracture is high and increases year by year with aging, mainly seen in elderly women. It is estimated that up to 890 new osteoporotic fractures occur worldwide each year, with vertebral compression fractures accounting for about half. The investigation of 2002 year-old regions in China shows that the incidence rate of vertebral compression fracture in people over 50 years old is 16.2%. With age, the incidence rate is increasing, reaching 37% by age 80. The scapulohumeral periarthritis has shoulder joint pain and inconvenient movement as main symptoms, can seriously affect the functional movement of shoulder joints, and causes the atrophy of deltoid muscles. Scapulohumeral periarthritis mostly occurs in middle-aged and later-aged people, with the peak of attack at 50-60 years old and the disease rarely occurs in people under 40 years old. According to foreign statistics, the incidence rate of scapulohumeral periarthritis accounts for 2% -5% of the general population, the female prevalence rate is higher than that of the male, and about 40% of patients with one-side scapulohumeral periarthritis can also have the opposite-side scapulohumeral periarthritis within 5-7 years. The prevalence rate of hemiplegic side limb pain caused by stroke is increased year by year, and the continuous and unbearable pain brings great pain to the mind and body of a patient.

Modern medicine is mainly used for treating the diseases by adopting non-steroidal anti-inflammatory drugs, hormones, immunosuppressants and the like, is mainly used for symptomatic treatment, treats symptoms and root causes, has limited treatment effect, needs long-term administration, has great side effect and is easy to form dependence. Clinical practice proves that the traditional Chinese medicine has more advantages than western medicines when being used for treating diseases such as the chronic viral hepatitis type virus, avoids toxic and side effects of chemical medicines, is suitable for long-term administration, shows the treatment advantages of the traditional Chinese medicine, and shows that the traditional Chinese medicine preparation has huge market.

The rheumatic arthritis, the compression fracture, the scapulohumeral periarthritis and the limb pain after stroke are 4 different diseases, for example, the rheumatic arthritis is characterized by pain, inflammation and pain of big joints and muscle wandering of limbs, the compression fracture is most common by osteoporosis centrum compression fracture and mainly shows intractable low back pain, the scapulohumeral periarthritis is a common disease which takes shoulder pain and limited shoulder joint movement as main symptoms, and the stroke patient has symptoms of unbearable limb pain on the hemiplegia side; however, the four herbs are mainly characterized by pain in muscles, bones and joints and difficulty in flexion and extension, and belong to arthralgia syndrome in Chinese medicine, so they can treat different diseases at the same time. The disease belongs to the syndrome of deficient origin and marked excess, the deficiency of origin is mainly caused by deficiency of qi and blood, deficiency of liver and kidney, and marked excess is caused by invasion of wind-cold-dampness, which causes various symptoms such as meridian obstruction of pathogenic qi, stagnation of qi and blood, transformation of damp pathogen into turbid, and obstructed blood circulation. Following the principle of treating both syndromes and treating different syndromes, the treatment should be based on the principle of dispelling wind and removing dampness, promoting blood circulation to remove blood stasis, strengthening the body resistance and eliminating pathogenic factors. At present, people are limited to using pungent and warm herbs, mainly for dispelling wind and cold, dredging collaterals and relieving pain.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, and develops a novel traditional Chinese medicine composition for treating arthralgia syndrome by summarizing the experience and good prescription related to treating the arthralgia syndrome from ancient times and present times under the guidance of the theory of traditional Chinese medicine. The traditional Chinese medicine composition has unique curative effects on rheumatic arthritis, compression fracture, scapulohumeral periarthritis and limb pain after stroke which belong to qi deficiency and blood stasis type or liver and kidney deficiency type according to syndrome differentiation, has no obvious adverse reaction, and is suitable for popularization and application.

The technical scheme adopted by the invention is as follows:

the active ingredients of the traditional Chinese medicine composition for treating the arthralgia comprise the following raw materials in parts by weight: notopterygium root: 1-3 parts of gentiana macrophylla: 1-6 parts, 1-3 parts of divaricate saposhnikovia root, 2-10 parts of kudzuvine root and radix bupleuri: 1-4 parts of vinegar rhizoma cyperi: 1-3 parts of Chinese angelica: 1-5 parts of red peony root: 1-4 parts of ligusticum wallichii: 1-4 parts of astragalus: 2-10 parts of codonopsis pilosula: 2-8 parts of bighead atractylodes rhizome: 1-6 parts of coix seed: 2-10 parts of bran-fried bighead atractylodes rhizome: 1-6 parts of dried orange peel: 1-4 parts of rhizoma pinelliae preparata: 1-3 parts of safflower: 1-6 parts of blanched peach kernel: 1-4 parts of loofah sponge: 1-4 parts of cassia twig: 1-3 parts of saline achyranthes root: 1-6 parts of teasel root: 2-6 parts.

In some examples of the traditional Chinese medicine composition, the raw material medicines comprise the following components in parts by weight: notopterygium root: 1-2 parts of gentiana macrophylla: 3-6 parts, 2-3 parts of divaricate saposhnikovia root, 6-8 parts of kudzuvine root and radix bupleuri: 2-4 parts of vinegar rhizoma cyperi: 1-2 parts of Chinese angelica: 3-5 parts of red peony root: 2-4 parts of ligusticum wallichii: 2-4 parts of astragalus: 6-10 parts of codonopsis pilosula: 3-8 parts of bighead atractylodes rhizome: 3-6 parts of coix seeds: 4-8 parts of bran-fried bighead atractylodes rhizome: 3-6 parts of dried orange peel: 2-4 parts of rhizoma pinelliae preparata: 2-3 parts of safflower: 2-6 parts of blanched peach kernel: 2-4 parts of loofah sponge: 2-4 parts of cassia twig: 2-3 parts of saline achyranthes root: 3-6 parts of teasel root: 3-6 parts.

In some examples of the traditional Chinese medicine composition, the raw material medicines comprise the following components in parts by weight: notopterygium root: 2 parts of gentiana macrophylla: 3 parts of radix sileris: 2 parts of kudzu root: 6 parts of radix bupleuri: 2 parts, vinegar rhizoma cyperi: 2 parts of Chinese angelica: 3 parts and red peony root: 3 parts of ligusticum wallichii: 3 parts of astragalus root: 6 parts of radix codonopsis: 3 parts of bighead atractylodes rhizome: 3 parts of coix seeds: 6 parts of bran-fried bighead atractylodes rhizome: 3 parts of dried orange peel: 2 parts and rhizoma pinellinae praeparata: 2 parts of safflower: 2, soaking peach kernels: 2 parts of loofah sponge: 2 parts of cassia twig: 2 parts of saline achyranthes root: 3 parts of teasel root: and 3 parts.

In some examples of the Chinese medicinal composition, the dosage form of the Chinese medicinal composition is an oral preparation.

In some examples of the traditional Chinese medicine composition, the oral agent is decoction, powder, granules, honeyed pills, capsules or soft capsules.

In some examples of the traditional Chinese medicine composition, the active ingredient of the bulk drug is an aqueous extract thereof.

In some examples of the Chinese medicinal composition, the arthralgia syndrome is caused by qi deficiency, blood stasis or liver and kidney deficiency.

In some examples of the Chinese medicinal composition, the arthromyodynia is selected from rheumatoid arthritis, compression fracture, scapulohumeral periarthritis or post-stroke limb pain.

In some examples of the composition of the traditional Chinese medicine,

the rheumatic arthritis is selected from the rheumatic arthritis of qi deficiency and blood stasis or liver and kidney deficiency type;

the compression fracture is selected from compression fracture of qi deficiency and blood stasis or liver and kidney deficiency type;

the scapulohumeral periarthritis is scapulohumeral periarthritis due to qi deficiency and blood stasis or liver and kidney deficiency;

the post-stroke limb pain is selected from post-stroke limb pain of qi deficiency and blood stasis or liver and kidney deficiency type.

The invention has the beneficial effects that:

some examples of the invention have unique curative effects on rheumatic arthritis, compression fracture, scapulohumeral periarthritis and limb pain after stroke which belong to qi deficiency and blood stasis type or liver and kidney deficiency type according to syndrome differentiation, have no obvious adverse reaction, and are suitable for popularization and application.

Some embodiments of the invention have better treatment effect on specific population which is diagnosed as arthralgia but is easy to relapse due to deficiency of vital qi.

Some examples of the invention, first, adopt the more common Chinese herbal medicine on the market as raw materials, have low cost, easy to make, the characteristic with apparent therapeutic effect; secondly, the prescription does not contain medicinal materials with larger toxic and side effects such as tripterygium wilfordii, nux vomica and the like, and has small stimulation to gastrointestinal tracts after long-term use; thirdly, starting from two aspects of replenishing qi and blood and promoting blood circulation to remove blood stasis, the health-care food can improve the immunity of human bodies and prevent the bone destruction.

Detailed Description

Based on the theory of syndrome differentiation and treatment of 'pathogenic qi deficiency', 'wind-cold-dampness mixed qi, arthralgia' and 'long-term disease-stasis' in traditional Chinese medicine, the inventor refers to a large number of ancient and modern documents, and prepares an oral traditional Chinese medicine preparation by combining the wind-damp-dispelling medicines, the blood-activating medicines and the tonifying medicines according to the traditional Chinese medicine formula theory and the advanced achievement of modern research of traditional Chinese medicines according to years of clinical research and skillfully according to the characteristics and the effects of different medicines.

In the recipe, Ge Gen and Yi ren are monarch drugs, Ge Gen issues and dispels pathogens, relieves muscles and promotes the production of body fluid, and is recorded in Ben Cao Jing Shu: kudzuvine root, radix Puerariae, also has the main action of resolving heat pathogen of yangming-warm disease, so it is indicated for diabetes, fever, heat accumulation in chest and diaphragm and vomiting. It is also indicated for arthralgia due to its divergent and ascending nature and wind-herbs property. "Yi ren is good at promoting diuresis, invigorating spleen and relaxing muscles and tendons", Ben Jing: the main tendons are spasm, unable to bend and stretch, arthralgia due to wind-dampness and descending qi. The combination of kudzu root and coix seed has more remarkable effect of eliminating dampness and removing arthralgia; radix astragali, radix gentianae macrophyllae, salted achyranthes bidentata, radix euphorbiae lathyris, angelica sinensis, radix paeoniae rubra and ligusticum wallichii are used as ministers, wherein the radix astragali is used in a large amount to tonify qi and strengthen exterior, and the section of famous medical records: the product has effects in invigorating qi, tonifying deficiency of male and female, and removing blood stasis of viscera. ' Qin jiao dispel wind-damp, clear damp-heat and relieve arthralgia, in this Jing, cloud: it is mainly indicated for cold and heat pathogen, arthralgia due to wind-cold-dampness, arthralgia of limbs, water discharge and diuresis. According to the theories of 'liver governing tendons' and 'kidney governing bones', the achyranthes root with salt and the teasel root are added to tonify the liver and the kidney and strengthen the bones and muscles, and according to the theories of 'blood stasis after long-term illness' and 'wind-treatment and blood-treatment first' in the traditional Chinese medicine, the angelica, the red paeony root, the Szechuan lovage rhizome and the safflower are taken, and the semen persicae which is blanched in boiled water is; retinervus Luffae fructus, ramulus Cinnamomi, rhizoma Atractylodis Macrocephalae Preparata with bran, pericarpium Citri Reticulatae, rhizoma Pinelliae Preparata, rhizoma Et radix Notopterygii, radix Saposhnikoviae, radix Codonopsis Preparata, and rhizoma Atractylodis Macrocephalae as adjuvant drugs, wherein retinervus Luffae fructus dispels pathogenic wind and unblocks collaterals, ramulus Cinnamomi warms channels, rhizoma Atractylodis Macrocephalae Preparata strengthens spleen and relieves distension, pericarpium Citri Reticulatae and rhizoma Pinelliae Preparata invigorate spleen and eliminate dampness, rhizoma Et radix Notopterygii and radix Saposhnikoviae dispel pathogenic wind and eliminate dampness, and radix astragali strengthens the effects of invigorating spleen and replenishing qi by adding radix Codonopsis Preparata; the bupleurum chinense and the vinegar-processed rhizoma cyperi are used for promoting qi circulation and relieving depression, so that the medicines are moved without stagnation, and the medicines are used together to play the effects of dispelling wind and removing dampness, promoting blood circulation and removing blood stasis, and strengthening body resistance and eliminating evil.

The modern traditional Chinese medicine pharmacological research shows that the traditional Chinese medicine can effectively control the development and the progress of diseases and achieve certain treatment effect when the traditional Chinese medicine is used for treating the rheumatic immune diseases such as the mandatory spondylitis, the rheumatism and the rheumatoid arthritis by regulating the cellular immunity and the humoral immunity. The pure traditional Chinese medicine preparation with obvious analgesic, anti-inflammatory and anticoagulant effects, invented by the inventor, can effectively improve blood circulation and reduce blood viscosity, thereby playing a role in regulating the immune function of an organism.

Kudzu root: sweet, pungent and cool, relieving the muscles and allaying fever, promoting the production of body fluid, promoting eruption, invigorating yang and stopping diarrhea. Is dried root of Pueraria lobata (Willd.) Ohwi or Pueraria thomsonii Benth. It is commonly indicated for exterior syndrome with fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency. Modern Chinese medicine researches believe that the kudzuvine root contains flavone or has the function of relieving spasm of smooth muscles and striated muscles.

Coix seed: sweet, light and cool, spleen-invigorating and dampness-excreting, arthralgia-relieving and diarrhea-checking, heat-clearing and pus-discharging, and is a dry mature seed kernel of Coix lacryma-jobil, var. ma-yuen (Roman.) Stapf which is a gramineous plant. Can be used for treating rheumatalgia, damp-heat loempe, damp-heat spasm of tendons, damp arthralgia, edema, lung atrophy, pulmonary abscess, cough with purulent blood, pharyngitis, carbuncle, and intestinal abscess with stranguria due to heat.

Astragalus root: sweet in flavor, warm in nature, tonifying qi and consolidating superficial resistance, inducing diuresis and expelling pus, healing sores and promoting granulation, which is the dry root of Astragalus membranaceus (Fisch.) Bge. of Leguminosae Astragasumsmbrannacus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Can be used for treating qi deficiency, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, prolapse of sub-organs, and unhealed wound. Modern pharmacological studies show that: radix astragali can enhance organism immunity and influence on anoxia tolerance and cold tolerance; can obviously reduce thrombosis and platelet adhesion rate, and has anti-inflammatory and antibacterial effects.

Large-leaved gentian: pungent, bitter and mild effects, expelling wind-damp, clearing damp-heat and relieving arthralgia, and is the dried root of Gentiana macrophylla pall.of Gentiana of Gentianaceae, Gentiana straminea Maxim.A.twist, Gentiana macrophylla Gentiana crassicaulis Duthie ex Burk. or Gentiana minifera Dahurica Fisch. Can be used for treating rheumatic arthralgia, spasm of tendons and vessels, soreness of bone joints, hectic fever after the day, and infantile malnutrition with fever. Modern research shows that: the gentiana macrophylla has obvious effects of easing pain, reducing swelling, abating fever and recovering joint functions on rheumatic arthritis and rheumatoid arthritis.

Salt achyranthes root: bitter, sour and neutral. Removing blood stasis, dredging channels, healing wound, nourishing liver and kidney, strengthening tendons and bones, drawing blood downward, promoting diuresis, and treating stranguria, and is root of Cyathula officinalis Kuan or Achyranthus bidentabl. It is mainly used for treating soreness and pain of waist and knees, flaccidity and weakness of lower limbs, amenorrhea due to blood stagnation, dysmenorrhea, postpartum blood stasis and abdominal pain, stranguria with blood due to heat-evil, traumatic injury, carbuncle, swelling and sore, and sore throat.

Teasel root: bitter and pungent with slight warm property, tonify liver and kidney, strengthen tendons and bones, continue fracture and stop metrorrhagia and metrostaxis. Is the dried root of Dipsacus asperoides C.Y.Cheng et T.M.ai (or Dipsacus asper Wall) of Dipsacaceae. Can be used for treating soreness of waist and knees, rheumatalgia, metrorrhagia, fetal leakage, and traumatic injury. Jiu xue Duan is mainly used for arthralgia due to wind-dampness and traumatic injury. Salted xu Duan is mostly used for soreness and weakness of waist and knees.

Chinese angelica: sweet and pungent with warm and warm properties, tonify blood and activate blood, regulate menstruation and alleviate pain, moisten intestines to relieve constipation. Is dried root of Angelica sinensis (Oliv.) Diels) belonging to family Umbelliferae. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. Modern pharmacological research shows that the angelica has the functions of inhibiting platelet aggregation, resisting thrombus, tranquilizing, relieving pain, resisting inflammation and protecting liver.

Red peony root: bitter and slightly cold, clear heat and cool blood, dissipate blood stasis and alleviate pain. Is dried root of Paeonia lactiflora pall or Paeonia veitchii Lynch of Ranunculaceae. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease. Modern pharmacological research shows that it has the functions of resisting thrombosis and resisting platelet aggregation.

Ligusticum wallichii: pungent and warm in flavor, promoting blood circulation and qi circulation, dispelling wind and relieving pain, and is dried rhizome of Ligusticum chuanxiong Hort (or Ligusticum wallichi Franch.) belonging to Umbelliferae. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia. Modern medical research shows that: rhizoma Ligustici Chuanxiong has effects of tranquilizing and relieving smooth muscle spasm, and the rhizoma Ligustici Chuanxiong alkaloid, ferulic acid and ligustilide have spasmolytic effects, and ligustilide is the main ingredient of spasmolytic

Cooked codonopsis pilosula: sweet, neutral, middle-jiao and qi-replenishing, spleen-invigorating and lung-benefiting, and is the dried root of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (West Codonopsis) of Campanulaceae, Codonopsis pilosula Nannf., var. modesta (Nannf.), L.T.Shen or Codonopsis tandshen Oliv. Can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes.

White atractylodes rhizome: bitter and sweet, warm, spleen-invigorating, qi-replenishing, dampness-drying, diuresis-inducing, antiperspirant, miscarriage-preventing, is the dried rhizome of Atractylodes macrocephala Koldz. Modern researches show that the bighead atractylodes rhizome can obviously enhance the capability of white blood cells to phagocytize staphylococcus aureus and enhance the immunity of organisms. In addition, it has anticoagulant effect, and after the healthy people take the water decoction or ethanol leaching solution of the white atractylodes rhizome, the prothrombin time and the blood coagulation time of the white atractylodes rhizome are both obviously prolonged.

Stir-frying white atractylodes rhizome with bran: bitter and sweet, warm, spleen-invigorating, qi-replenishing, dampness-drying, diuresis-inducing, sweating-suppressing, miscarriage-preventing, is a dried rhizome of Atractylodes macrocephala Koldz of Compositae, wherein Atractylodes macrocephala Koldz stir-fried with bran can alleviate dryness, strengthen spleen-invigorating and flatulence-relieving effects by being added into the middle with bran, and can be used for treating incoordination between spleen and stomach, transport and transformation disorder, anorexia, fullness and tiredness, asthenia, exterior deficiency and spontaneous perspiration.

Loofah sponge: sweet and mild, dispel wind, dredge collaterals, activate blood circulation, and promote lactation, which are the vascular bundles of dried mature fruits of Luffa cylindrica (L.) Roem. Can be used for treating arthralgia and spasm, distending pain in chest and hypochondrium, and galactostasis.

Dried orange peel: bitter and pungent, warm, qi-regulating, spleen-invigorating, dampness-drying, and phlegm-resolving, is the dried mature pericarp of Citrus reticulata Blanco of Rutaceae and its cultivar. Can be used for treating qi stagnation of spleen and stomach, abdominal distention, nausea, emesis, anorexia, cough, excessive phlegm, fullness and distress in chest and diaphragm, and globus hystericus. The research shows that the pharmacological effects are as follows: 1. eliminating phlegm and relieving asthma; 2. anti-inflammatory and anti-allergic effects; 3. resisting pathogenic microorganism.

Rhizoma pinelliae preparata: pungent and warm in flavor and warm in property, dry dampness and resolve phlegm, check adverse rise of qi and stop vomiting, relieve distension and fullness and dissipate stagnation, and is a dry tuber of a plant Pinellia ternate Pinellia ternata (Thunb.) Breit. It is mainly used for eliminating dampness and phlegm. Can be used for treating cough and asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, phlegm syncope and headache.

Safflower: pungent and warm, promoting blood circulation and dredging meridians, removing blood stasis and relieving pain, is dried flower of Carthamus tinctorius L. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, and traumatic injury. Pharmacological research shows that: it has antifatigue, antiinflammatory, tranquilizing and analgesic effects, and the safflower yellow contained in the medicine has obvious anticoagulant effect in rabbit experiment.

Blanching the peach kernels: bitter, sweet and mild, has the functions of promoting blood circulation to remove blood stasis and relaxing bowel, and is dry mature seeds of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma. Amygdalin contained in semen Persicae can absorb inflammation. Experiments prove that the water extract of the peach kernel can inhibit the generation of skin allergic antibodies and hemolytic cells in serum and has anti-inflammatory and anti-allergic effects.

Cassia twig: pungent, warm and sweet, inducing sweat to relieve muscle weakness, warming and dredging channels and collaterals, supporting yang and regulating qi, and calming and descending qi, and is the dry twig of Cinnamomum Cassia Presl of Lauraceae. Can be used for treating exterior syndrome due to affection of exogenous wind-cold, rheumatalgia, stomach cold, abdominal pain, amenorrhea, dysmenorrhea, phlegm and fluid retention in bladder. The cassia twig has the following pharmacological effects: expanding blood vessels and promoting sweating; relieving fever and pain; sedation, anticonvulsant; anti-inflammatory and anti-allergic; antibacterial and antiviral effects.

Notopterygium root: pungent and bitter with warm nature, dispel cold, dispel wind, remove dampness and alleviate pain. Is dried rhizome and root of Notopterygium incisum of Umbelliferae family or Notopterygium forbesii Boiss. It can be used for treating wind-cold type common cold, arthralgia due to wind-cold-dampness, neck stiffness, spasm of muscles, soreness of bone joints, edema due to wind-damp, superficial infection, and skin sore.

Wind prevention: pungent, warm and sweet, exterior syndrome relieving, pathogenic wind expelling, dampness eliminating, and spasmolytic, and is dried root of Saposhnikovia divaricata (Turcz.) Schischk. Can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.

Bupleurum chinense nakai: bitter and slightly cold, and relieving exterior and interior, soothing liver and invigorating yang, and is the dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia. Modern pharmacological research proves that: bupleuri radix has effects of relieving fever, and tranquilizing and relieving pain.

Vinegar processed nutgrass galingale rhizome: pungent, slightly bitter, slightly sweet, mild, promoting qi circulation, resolving stagnation, regulating menstruation and relieving pain, and is dried rhizome of Cyperus rotundus L. Can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea, and dysmenorrhea.

The present invention is further illustrated by the following examples.

Example 1: decoction preparation

The traditional Chinese medicine comprises the following active ingredients in parts by weight: notopterygium root: 2. large-leaved gentian: 3. wind prevention: 2. kudzu root: 6. bupleurum root: 2. vinegar processed nutgrass galingale rhizome: 2. chinese angelica: 3. red peony root: 3. ligusticum wallichii: 3. astragalus root: 6. codonopsis pilosula: 3. white atractylodes rhizome: 3. coix seed: 6. stir-frying white atractylodes rhizome with bran: 3. dried orange peel: 2. rhizoma pinelliae preparata: 2. safflower: 2. blanching the peach kernels: 2. loofah sponge: 2. cassia twig: 2. salt achyranthes root: 3. teasel root: 3.

wherein, one dose of decoction comprises the following components: notopterygium root: 20g, gentiana macrophylla: 30g, radix sileris: 20g, kudzu root: 60g, radix bupleuri: 20g, vinegar-processed rhizoma cyperi: 20g, Chinese angelica: 30g, red peony root: 30g, Ligusticum wallichii: 30g, radix astragali: 60g, radix codonopsis: 30g, white atractylodes rhizome: 30g, coix seed: 60g, bran-fried bighead atractylodes rhizome: 30g, dried orange peel: 20g, rhizoma pinelliae preparata: 20g, safflower: 20g, heating peach kernels: 20g, loofah sponge: 20g, cassia twig: 20g, 30g of salt achyranthes root, teasel root: 30 g. The decoction is prepared by the following steps:

soaking a dose of the traditional Chinese medicine in 1000ml of water for about 30 minutes, then decocting with strong fire for 20 minutes, decocting with slow fire for 20 minutes, filtering to remove residues, and obtaining the decocted liquid medicine which is the required traditional Chinese medicine. Decocting one dose for 2 times, and decocting 400-600 ml of liquid medicine.

Example 2: powder preparation

The traditional Chinese medicine comprises the following active ingredients in parts by weight: notopterygium root: 1. large-leaved gentian: 6. wind prevention: 1. kudzu root: 2. bupleurum root: 3. vinegar processed nutgrass galingale rhizome: 1. chinese angelica: 3. red peony root: 4. ligusticum wallichii: 1. astragalus root: 8. codonopsis pilosula: 5. white atractylodes rhizome: 5. coix seed: 8. stir-frying white atractylodes rhizome with bran: 2. dried orange peel: 1. rhizoma pinelliae preparata: 2. safflower: 4. blanching the peach kernels: 1. loofah sponge: 3. cassia twig: 1. salt achyranthes root: 6. teasel root: 6.

grinding the Chinese medicinal materials into fine powder, mixing the above fine powders, sieving, and packaging.

Example 3: granules

The traditional Chinese medicine comprises the following active ingredients in parts by weight: notopterygium root: 3. large-leaved gentian: 1. wind prevention: 3. kudzu root: 8. bupleurum root: 2. vinegar processed nutgrass galingale rhizome: 2. chinese angelica: 5. red peony root: 2. ligusticum wallichii: 3. astragalus root: 2. cooked codonopsis pilosula: 8. white atractylodes rhizome: 2. coix seed: 2. stir-frying white atractylodes rhizome with bran: 4. dried orange peel: 3. rhizoma pinelliae preparata: 3. safflower: 6. blanching the peach kernels: 4. loofah sponge: 2. cassia twig: 2. salt achyranthes root: 4. teasel root: 4.

extracting the above materials at appropriate ratio by percolation method with 60% ethanol or Chinese liquor as solvent, recovering ethanol from the extractive solution, evaporating and concentrating to obtain soft extract, adding appropriate adjuvant, making soft mass, granulating, drying, grading, and packaging.

Example 4: honey pill

The traditional Chinese medicine comprises the following active ingredients in parts by weight: notopterygium root: 2. large-leaved gentian: 3. wind prevention: 2. kudzu root: 10. bupleurum root: 1. vinegar processed nutgrass galingale rhizome: 1. chinese angelica: 3. red peony root: 3. ligusticum wallichii: 2. astragalus root: 7. codonopsis pilosula: 6. white atractylodes rhizome: 6. coix seed: 10. stir-frying white atractylodes rhizome with bran: 1. dried orange peel: 4. rhizoma pinelliae preparata: 1. safflower: 3. blanching the peach kernels: 3. loofah sponge: 1. cassia twig: 2. salt achyranthes root: 1, teasel root: 2.

drying the above materials by insolation, pulverizing into fine powder with a pulverizer, mixing with Mel at a weight ratio of 1: 1.2-1.5, decocting Mel with slow fire and then with strong fire, pouring Mel into the medicinal powder when it is hot, stirring until the medicinal Mel is mixed, and standing to warm until it is hot and then making into pill.

Example 5: capsule preparation

The traditional Chinese medicine comprises the following active ingredients in parts by weight: notopterygium root: 2. large-leaved gentian: 4. wind prevention: 2. kudzu root: 7. bupleurum root: 4. vinegar processed nutgrass galingale rhizome: 3. chinese angelica: 1. red peony root: 1. ligusticum wallichii: 4. astragalus root: 10. codonopsis pilosula: 2. white atractylodes rhizome: 1. coix seed: 7. stir-frying white atractylodes rhizome with bran: 6. dried orange peel: 2. rhizoma pinelliae preparata: 2. safflower: 1. blanching the peach kernels: 2. loofah sponge: 4. cassia twig: 3. salt achyranthes root: 3. teasel root: 3.

preparing the above Chinese medicinal materials into medicinal liquid, mixing and dissolving gelatin, glycerol and water by pressing method to obtain uniform adhesive tape, placing the medicinal liquid between two layers of adhesive tapes, and pressing with steel plate mold or rotary mold.

The invention is applicable to:

1) rheumatic arthritis of qi deficiency and blood stasis type or liver and kidney deficiency type;

2) compression fracture of qi deficiency and blood stasis type or liver and kidney deficiency type;

3) scapulohumeral periarthritis due to qi deficiency and blood stasis or deficiency of liver and kidney;

4) limb pain after stroke of qi deficiency and blood stasis type or liver and kidney deficiency type.

It is contraindicated for arthralgia due to wind-heat and pregnant women.

The composition has the following treatment effects on the rheumatic arthritis:

the evaluation table of the clinical symptom curative effect of the rheumatoid arthritis patient in this embodiment is formulated by referring to "standard of curative effect for diagnosis of traditional Chinese medicine syndrome", the sum of the clinical symptom and the physical sign score of the patient is counted according to the evaluation table of the clinical symptom curative effect, and the improvement percentage evaluates the curative effect according to the following formula:

the reduction rate is (total fraction before treatment-total fraction after treatment)/total fraction before treatment x 100%

And (3) clinical control: the reduction rate is more than or equal to 90 percent, and the effect is shown: the reduction rate is more than or equal to 70% and less than 90%, and the effect is as follows: the reduction rate is more than or equal to 30% and less than 70%, and the method is ineffective: the reduction rate was < 30%.

The patients with rheumatic arthritis are clinically analyzed and index evaluated according to the syndrome differentiation of traditional Chinese medicine (qi deficiency and blood stasis type, liver and kidney deficiency type).

The 86 patients with the qi deficiency and blood stasis type rheumatoid arthritis are randomly divided into 43 cases of an observation group and a control group, wherein the observation group comprises 20 men and 23 women, the average age (40.3 +/-1.4) years and the average course (4.4 +/-0.5) years; 25 men and 18 women in the control group, mean age (39.3 + -3.2) years, mean course of disease (5.2 + -0.4); the observation group is treated by the main drug in the embodiment 1 (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the medicine is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment course is 1 month; the control group is given conventional oral diclofenac sodium sustained release tablets with the dosage of 75mg/d and the treatment course of 1 month; after the treatment course is finished, the effective reduction rate of the observation group is 85 percent and is obviously higher than that of the control group by 70.3 percent, and meanwhile, the scores of the quality of life comprehensive assessment questionnaires before and after two groups of treatment are observed.

The 64 patients with the liver-kidney deficiency type rheumatoid arthritis are randomly divided into 34 observation groups and 30 control groups, wherein 42 men and 22 women are 22 women, the ages of the two groups are 35-85 years old, and the average (62.5 +/-7.3) years old; the control group is given diclofenac sodium sustained-release tablets at 75mg/d for 4 weeks; the observation group is treated by the main drug of the embodiment 1 on the basis of the control group (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the main drug is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment lasts for 4 weeks; after the treatment course is finished, 8 cases are cured, 9 cases with obvious effect, 14 cases with effect and 3 cases with no effect are cured in a treatment group, and the total effective rate is 90%; the control group has 3 cured cases, 7 obvious effects, 14 effective cases and 6 ineffective cases, and the total effective rate is 80 percent.

The composition has the following effects on the treatment of the compression fracture:

the evaluation table of the clinical symptom curative effect of the compression fracture patient in this embodiment is formulated by referring to "standard of curative effect for diagnosis of traditional Chinese medicine syndrome", the sum of the clinical symptom and the physical sign score of the patient is counted according to the evaluation table of the clinical symptom curative effect, and the curative effect is evaluated according to the following formula of the improvement percentage, wherein the calculation formula is as follows:

The compression fracture patients are clinically analyzed and index evaluated according to the syndrome differentiation of traditional Chinese medicine (qi deficiency and blood stasis type, liver and kidney deficiency type).

56 patients with the qi deficiency and blood stasis type compression fracture are randomly divided into an observation group and a control group, wherein the observation group comprises 10 men and 18 women, the average age (57.7 +/-5.4) years and the average course (2.8 +/-1.4) years; 11 men and 17 women in the control group, mean age (60.2 +/-7.1) years and mean course of disease (3.1 +/-0.5); the observation group is treated by the main drug in the embodiment 1 (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the medicine is taken 2 times in the morning and at night, and about 200 ml and 300 ml are taken every time), and the treatment course is 3 months; the control group adopts the cushion pillow to be over-extended and is used for bed and the lumbar and back muscle function exercise treatment for 3 months; after the treatment course is finished, the effective reduction rate of the observation group is 89.5 percent and is obviously higher than 78.56 percent of the control group, and meanwhile, the scores of the quality of life comprehensive assessment questionnaires before and after two groups of treatment are observed.

60 patients with liver-kidney deficiency type compression fracture are randomly divided into 35 observation groups and 25 control groups, wherein 34 men and 26 women have the age of 66-83 years, and the average (69.4 +/-2.5) years is old; the control group is subjected to the functional exercise treatment of the over-extended bolster bed and the lumbar and back muscles for 16 weeks; the observation group is treated by the main drug of the embodiment 1 on the basis of the control group (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the main drug is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment period is 16 weeks; after the treatment course is finished, 8 cases are cured in a treatment group, 10 cases are obviously effective, 15 cases are effective, 2 cases are ineffective, and the total effective rate is 95%; the control group cures 1 case, has obvious effect of 7 cases, has 13 cases and no effect of 4 cases, and has a total effective rate of 85 percent.

The composition has the following treatment effects on scapulohumeral periarthritis:

the evaluation table of the clinical symptom curative effect of the scapulohumeral periarthritis patient is formulated according to the standard of traditional Chinese medicine disease diagnosis curative effect, the sum of the clinical symptom and the physical sign score of the patient is counted according to the evaluation table of the clinical symptom curative effect, the improvement percentage is evaluated according to the following formula, and the calculation formula is as follows:

Clinical analysis and index evaluation are carried out on patients with scapulohumeral periarthritis according to the traditional Chinese medicine syndrome differentiation (qi deficiency and blood stasis type, liver and kidney deficiency type).

80 patients with qi deficiency and blood stasis type scapulohumeral periarthritis are randomly divided into 40 cases of observation group and control group, wherein the observation group comprises 24 men and 16 women, the average age (36.8 + -2.1) years and the average course (3.1 + -5.2) years; 21 men and 19 women in the control group, mean age (38.1 +/-2.5) years and mean course of disease (2.8 +/-3.8); the observation group is treated by the main drug in the embodiment 1 (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the medicine is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment course is 1 month; the control group is administered ibuprofen sustained release capsule 0.3g/qd each time, and is orally taken, with a treatment course of 1 month; after the treatment course is finished, the effective reduction rate of the observation group is 96.4 percent and is obviously higher than that of the control group by 90.1 percent, and meanwhile, the scores of the comprehensive assessment questionnaires of the quality of life before and after two groups of treatment are observed.

106 patients with liver and kidney deficiency type scapulohumeral periarthritis are randomly divided into 56 observation groups and 50 control groups, wherein 66 men and 40 women are aged 38-75 years, and the average (43.2 +/-2.7) year is old; the control group is administered with ibuprofen sustained release capsule 0.3g/qd each time, and is orally taken for 4 weeks; the observation group is treated by the main drug of the embodiment 1 on the basis of the control group (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the main drug is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment lasts for 4 weeks; after the treatment course is finished, 10 cases are cured in a treatment group, 28 cases are obviously effective, 17 cases are effective, 1 case is ineffective, and the total effective rate is 98%; the control group has 5 cured cases, 13 obvious effects, 27 effective cases and 5 ineffective cases, and the total effective rate is 90.2 percent.

The composition has the following effects on treating limb pain after stroke:

the evaluation table of the clinical symptom curative effect of the post-stroke limb pain patient in the embodiment is formulated according to the standard of the traditional Chinese medicine disease diagnosis curative effect, the sum of the clinical symptom and the physical sign score of the patient is counted according to the evaluation table of the clinical symptom curative effect, the improvement percentage is evaluated according to the following formula, and the calculation formula is as follows:

Clinical analysis and index evaluation are carried out on patients with limb pain after stroke according to the syndrome differentiation of traditional Chinese medicine (qi deficiency and blood stasis type, liver and kidney deficiency type).

112 patients suffering from limb pain after qi deficiency and blood stasis type stroke are randomly divided into an observation group and a control group, wherein the observation group comprises 30 men and 26 women, the average age (37.1 +/-3.7) years and the average course (5.7 +/-2.7) years; 27 men and 29 women in the control group, mean age (36.1 +/-1.8) and mean course of disease (4.1 +/-5.8); the observation group is treated by the main drug in the embodiment 1 (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the medicine is taken 2 times in the morning and at night, and about 200 ml and 300 ml are taken every time), and the treatment course is 3 months; mecobalamin of the control group is dripped for 1 time/day, and the treatment course is 3 months; after the treatment course is finished, the effective reduction rate of the observation group is 91.2 percent and is obviously higher than that of the control group by 87.8 percent, and meanwhile, the scores of the comprehensive assessment questionnaires of the quality of life before and after two groups of treatment are observed.

250 patients with liver and kidney deficiency type post-stroke limb pain are randomly divided into 150 observation groups and 100 control groups, wherein 130 male patients and 120 female patients are aged 33-86 years, and the average (47.7 +/-1.2) years is aged; the control group was administered mecobalamin 1 time/day, and was administered by intravenous drip for 3 months; the observation group is treated by the main drug of the embodiment 1 on the basis of the control group (the traditional Chinese medicine is decocted and orally taken, one dose is taken every day, the main drug is taken 2 times in the morning and at the evening, and about 200 ml and 300 ml are taken every time), and the treatment period is 3 months; after the treatment course is finished, the treatment group cures 20 cases, has obvious effect of 56 cases, has 70 cases and 16 cases of no effect, and has total effective rate of 89.6 percent; the control group has 8 cured cases, 28 obvious effects, 36 effective cases and 6 ineffective cases, and the total effective rate is 83.5 percent.

Claims

1. The active ingredients of the traditional Chinese medicine composition for treating the arthralgia comprise the following raw materials in parts by weight: notopterygium root: 1-3 parts of gentiana macrophylla: 1-6 parts, 1-3 parts of divaricate saposhnikovia root, 2-10 parts of kudzuvine root and radix bupleuri: 1-4 parts of vinegar rhizoma cyperi: 1-3 parts of Chinese angelica: 1-5 parts of red peony root: 1-4 parts of ligusticum wallichii: 1-4 parts of astragalus: 2-10 parts of codonopsis pilosula: 2-8 parts of bighead atractylodes rhizome: 1-6 parts of coix seed: 2-10 parts of bran-fried bighead atractylodes rhizome: 1-6 parts of dried orange peel: 1-4 parts of rhizoma pinelliae preparata: 1-3 parts of safflower: 1-6 parts of blanched peach kernel: 1-4 parts of loofah sponge: 1-4 parts of cassia twig: 1-3 parts of saline achyranthes root: 1-6 parts of teasel root: 2-6 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: the traditional Chinese medicine comprises the following raw materials in parts by weight: notopterygium root: 1-2 parts of gentiana macrophylla: 3-6 parts, 2-3 parts of divaricate saposhnikovia root, 6-8 parts of kudzuvine root and radix bupleuri: 2-4 parts of vinegar rhizoma cyperi: 1-2 parts of Chinese angelica: 3-5 parts of red peony root: 2-4 parts of ligusticum wallichii: 2-4 parts of astragalus: 6-10 parts of codonopsis pilosula: 3-8 parts of bighead atractylodes rhizome: 3-6 parts of coix seeds: 4-8 parts of bran-fried bighead atractylodes rhizome: 3-6 parts of dried orange peel: 2-4 parts of rhizoma pinelliae preparata: 2-3 parts of safflower: 2-6 parts of blanched peach kernel: 2-4 parts of loofah sponge: 2-4 parts of cassia twig: 2-3 parts of saline achyranthes root: 3-6 parts of teasel root: 3-6 parts.

3. The traditional Chinese medicine composition according to claim 2, characterized in that: the traditional Chinese medicine comprises the following raw materials in parts by weight: notopterygium root: 2 parts of gentiana macrophylla: 3 parts of radix sileris: 2 parts of kudzu root: 6 parts of radix bupleuri: 2 parts, vinegar rhizoma cyperi: 2 parts of Chinese angelica: 3 parts and red peony root: 3 parts of ligusticum wallichii: 3 parts of astragalus root: 6 parts of radix codonopsis: 3 parts of bighead atractylodes rhizome: 3 parts of coix seeds: 6 parts of bran-fried bighead atractylodes rhizome: 3 parts of dried orange peel: 2 parts and rhizoma pinellinae praeparata: 2 parts of safflower: 2, soaking peach kernels: 2 parts of loofah sponge: 2 parts of cassia twig: 2 parts of saline achyranthes root: 3 parts of teasel root: and 3 parts.

4. The traditional Chinese medicine composition according to claim 1, characterized in that: the dosage form of the traditional Chinese medicine composition is oral preparation.

5. The traditional Chinese medicine composition according to claim 4, wherein: the oral preparation is decoction, powder, granule, honeyed pill, capsule or soft capsule.

6. The Chinese medicinal composition according to any one of claims 1 to 3, wherein: the active ingredients of the raw material medicines are aqueous extracts thereof.

7. The Chinese medicinal composition according to any one of claims 1 to 5, wherein: the arthralgia syndrome is caused by qi deficiency and blood stasis or liver and kidney deficiency.

8. The traditional Chinese medicine composition according to claim 7, wherein: the arthromyodynia is selected from rheumatic arthritis, compression fracture, scapulohumeral periarthritis or limb pain after stroke.

9. The traditional Chinese medicine composition according to claim 8, wherein: