CN104547512A - Pharmaceutical composition for treating pharyngeal diseases, as well as preparation method thereof - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating pharyngeal diseases, as well as a preparation method thereof. The composition is prepared by decocting and extracting the following traditional Chinese medicinal materials in parts by weight: 32-50 parts of cortex moutan radicis, 0.1-0.5 part of menthol, 32-50 parts of flos chrysanthemi, 32-50 parts of radix platycodonis, 20-30 parts of prepared pinellia tuber, 40-56 parts of radix rehmanniae recens, 40-56 parts of radix scrophulariae, 20-30 parts of periostracum cicadae, 32-50 parts of radix clematidis, 40-56 parts of radix salviae miltiorrhizae, 40-56 parts of radix angelicae sinensis, 40-56 parts of radix ophiopogonis, 32-50 parts of fructus schisandrae chinensis, 32-50 parts of poria, 20-30 parts of radix glycyrrhizae. The pharmaceutical composition is significant in efficacy, high in safety, and in addition, the treatment cost is low, so that the pharmaceutical composition is applicable to use in the clinical treatment of primary levels having common medical conditions.

Description

A kind of pharmaceutical composition for the treatment of disease of pharynx and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of disease of pharynx and preparation method thereof.

Background technology

Disease of pharynx comprises pharyngalgia dry pharynx, pharyngeal scorching hot, a series of diseases such as dysphagia, pharynx foreign body sensation disease.Pharynx foreign body sensation disease, also known as pharyngoneurosis, the traditional Chinese medical science claims " globus hystericus ", refers to that pharyngeal or bottleneck throat has foreign body sensation, obstruction sense, constriction, tight bundle sense etc., one group of neural body syndrome of spirit that self-induction hypopnea, collar can not link closely.With swallow relevant, but on the feed and drinking-water time there is no these sensations and one of Without dysphagia group of pharynx organ disease, also make pharyngeal generation abnormal sensory by the reflection of nerve and conduction.Pharyngeal nerve is very abundant, and pharynx rear wall has pharyngeal plexus, containing vagus nerve, nervus glossopharyngeus, accessory nerve, cervical sympathetic nerve branch and nervi trigeminus branch.The pharynx modal main suit of foreign body sensation disease is like soft thing blocking throat, but does not affect feed, and can not swallow, that tells does not go out.Normal with emotion changes, weight differs, and often heave a deep sigh with uncomfortable in chest, but toposcopy positive sign is few, secretions is few, and body of the tongue is light red, thin white fur of tongue.The generation of primary disease can with local factors such as pharyngeal, esophaguses for trigger point or trigger district, and some inappreciable factors can stimulate the sensory nerve ending in excited hyperfunction state, increase the weight of foreign body sensation, thus form certain vicious cycle.

Doctor trained in Western medicine quite feels thorny in this disease for the treatment of, and the pathogeny mainly due to primary disease is indefinite.The traditional Chinese medical science think many because of feelings will smooth, depression of liver-QI, mechanism of qi rises to be sent out not normal, causes dysfunction of the spleen in transportation, accumulatively wet raise phlegm, sick in non-return larynx; It belongs to insubstantial phlegm, does not occur the disease of expectoration, and heavy time light during symptom with emotion changes.Normal with " BANXIA HOUPU TANG " master's in " Medical Treasures of the Golden Chamber ".

Summary of the invention

In view of the inherent advantage that Chinese traditional treatment disease of pharynx exists, the object of the invention is to through a large amount of screenings to drug component, restructuring, trial, again by a large amount of clinical experimental study, thus provide a kind of pharmaceutical composition for the treatment of disease of pharynx and preparation method thereof.

The object of the present invention is achieved like this:

Treat a pharmaceutical composition for disease of pharynx, this pharmaceutical composition by following weight portion traditional Chinese medicinal material raw materials through decocting extract be prepared from: Cortex Moutan 32-50 part, Mentholum 0.1-0.5 part, Flos Chrysanthemi 32-50 part, Radix Platycodonis 32-50 part, Rhizoma Pinelliae Preparata 20-30 part, Radix Rehmanniae 40-56 part, Radix Scrophulariae 40-56 part, Periostracum Cicadae 20-30 part, Radix Clematidis 32-50 part, Radix Salviae Miltiorrhizae 40-56 part, Radix Angelicae Sinensis 40-56 part, Radix Ophiopogonis 40-56 part, Fructus Schisandrae Chinensis 32-50 part, Poria 32-50 part, Radix Glycyrrhizae 20-30 part.

Preferably, the pharmaceutical composition of above-mentioned treatment disease of pharynx, its by following weight portion traditional Chinese medicinal material raw materials through decocting extract be prepared from: Cortex Moutan 38-42 part, Mentholum 0.1-0.3 part, Flos Chrysanthemi 38-42 part, Radix Platycodonis 38-42 part, Rhizoma Pinelliae Preparata 23-25 part, Radix Rehmanniae 46-50 part, Radix Scrophulariae 46-50 part, Periostracum Cicadae 23-25 part, Radix Clematidis 38-42 part, Radix Salviae Miltiorrhizae 46-50 part, Radix Angelicae Sinensis 46-50 part, Radix Ophiopogonis 46-50 part, Fructus Schisandrae Chinensis 38-42 part, Poria 38-42 part, Radix Glycyrrhizae 23-25 part.

In a most preferred embodiment of the present invention, the pharmaceutical composition of above-mentioned treatment disease of pharynx is prepared from through decocting extraction by the traditional Chinese medicinal material raw materials of following weight portion: be prepared from by the Chinese crude drug of following weight portion: Cortex Moutan 40 parts, Mentholum 0.2 part, Flos Chrysanthemi 40 parts, Radix Platycodonis 40 parts, Rhizoma Pinelliae Preparata 24 parts, Radix Rehmanniae 48 parts, Radix Scrophulariae 48 parts, Periostracum Cicadae 24 parts, Radix Clematidis 40 parts, Radix Salviae Miltiorrhizae 48 parts, Radix Angelicae Sinensis 48 parts, Radix Ophiopogonis 48 parts, Fructus Schisandrae Chinensis 40 parts, 40 parts, Poria, 24 parts, Radix Glycyrrhizae.

Again further preferably, the pharmaceutical composition of described treatment disease of pharynx is oral liquid, granule, tablet, pill and capsule.By traditional Chinese medicinal material raw materials after decocting extraction is prepared into Chinese medicine extract and adds adjuvant, oral liquid, granule, tablet or capsule can be prepared into according to the common process of this area.

Present invention also offers the preparation method of the oral liquid of above-mentioned treatment disease of pharynx, the method comprises the steps: except Mentholum, takes other medical material and merges, decoct with water 1-4 time, decocting liquid filters, and adds the Mentholum with dissolve with ethanol, and mixing filters, embedding, sterilizing, to obtain final product.

Preferably, the preparation method of the oral liquid for the treatment of disease of pharynx as mentioned above, other wherein said medical material decocts with water 3 times after merging, first time 0.8-1.2 hour, second time 0.6-0.8 hour, third time 0.4-0.6 hour.

Found by clinical experimental study, the pharmaceutical composition nourishing YIN and clearing away heat be prepared from by above-mentioned Chinese crude drug, nourish blood wind dispelling, and in treatment disease of pharynx, have significant curative effect, treated effect reaches more than 95%.Therefore, second object of the present invention is to provide a kind of new pharmaceutical use, the application of namely above-mentioned pharmaceutical composition in the medicine of preparation treatment disease of pharynx.Preferably, described disease of pharynx comprises dry pharynx pharyngalgia, dysphagia and pharynx foreign body sensation disease.

According to Chinese medicine Historical Data Data About, the traditional Chinese medicinal material raw materials selected by the present invention has following pharmacologically active and function cures mainly:

Cortex Moutan: the dry root bark selecting ranunculaceae peony Paeonia suffruticosa Andr..Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Mentholum is a kind of saturated cyclic alcohol extracted in labiate Herba Menthae herb, and character is colourless needles or prism-shaped crystallization or white crystalline powder.Dispelling wind; Heat clearing away; Main anemopyretic cold; Headache; Conjunctival congestion; Laryngopharynx swelling and pain; Toothache; Skin pruritus.

Flos Chrysanthemi: the effect with dispelling wind, heat clearing away, improving eyesight, removing toxic substances; The disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Be selected from the dry capitulum of feverfew Flos Chrysanthemi Chrysanthemum morifolium Ramat.

Radix Platycodonis: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm; Control exogenous cough, laryngopharynx swelling and pain, be applicable to affection of exogenous wind-cold, laryngopharynx swelling and pain, lung abscess, cough vomiting bloody pus, the diseases such as dysentery expectorant stomachache.Select the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC..

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.Select the dry tuber of aroid Rhizoma Pinelliae Pinelliaternata (Thunb.) Breit..

Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid; For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.For the tuber of the drying of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmanniaglutinosa Libosch., also claim Radix Rehmanniae.

Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing; Cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Be selected from the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..

Periostracum Cicadae: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic; For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.Exuviae shell when selecting the larva of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius to sprout wings.

Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump; Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck.

Radix Salviae Miltiorrhizae: the dry root selecting dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhizaBge..Have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, effect of nourishing blood to tranquillize the mind; Cure mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Select the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.

Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Be selected from the dried root of Liliaceae Ophiopogon plant OphiopogonJaponicus Radix Ophiopogonis (Thunb.) Ker-Gawl..

Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Poria: there is diuretic, effect of eliminating dampness by diuresis diuresis; Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.Select the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select as dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. G.inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G.glabra L..

Pharmaceutical composition of the present invention with the Rhizoma Pinelliae, Radix Platycodonis for monarch drug, with Poria, Mentholum, Periostracum Cicadae, Flos Chrysanthemi, Radix Clematidis, Radix Salviae Miltiorrhizae, when being classified as ministerial drug, with Cortex Moutan, Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Schisandrae Chinensis for adjuvant drug, with Radix Glycyrrhizae for making medicine, in side, the Rhizoma Pinelliae, Radix Platycodonis share sending down the abnormal ascending QI eliminating stagnation, and lung qi dispersing eliminates the phlegm; The sweet light eliminating dampness by diuresis spleen invigorating of Poria, to help Rhizoma Pinelliae lowering the adverse-rising QI and eliminating phlegm, Mentholum, Periostracum Cicadae, Flos Chrysanthemi wind and heat dispersing, Radix Clematidis dehumidifying is loose long-pending, helps Radix Platycodonis lung qi dispersing to eliminate the phlegm altogether, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, helps the Rhizoma Pinelliae altogether, Radix Platycodonis eliminating stagnation eliminates the phlegm; Cortex Moutan, Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Schisandrae Chinensis clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, stomach-Yin must be supported, and lung Tianjin is able to defeated cloth, and asthenic fire is from holding back, and mental disorder is from disappearing; Radix Glycyrrhizae is expelling phlegm for arresting cough not only, and can also nourishing the stomach gas, building up the spleen to supplement the lung, raw YIN edema and pathogenic fire reducing is evil, coordinating the actions of various ingredients in a prescription, the untoward reaction of cushion.Compared with prior art, tool of the present invention has the following advantages and progress significantly: (1) good effect.After pharynx foreign body sensation disease patient takes medicine composite for curing of the present invention, subjective symptoms disappears, and foreign sense, without uncomfortable in chest, heaves a deep sigh, and emotion is happy, and treated effect reaches more than 95%.(2) safety is high.Due to medicine of the present invention, to adopt Chinese medicine material to be prepared from toxicity low, untoward reaction is few, and patient medication is safer, and without the need to antibiotic, patient can not be made to produce drug resistance to antibiotic.(3) treatment cost is low.Crude drug source is wide, and without rare medicinal herbs, preparation technology is simple, taking convenience, moderate, and the basic unit's clinical treatment being applicable to medical condition general uses.

Detailed description of the invention

The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the present invention is described, instead of limitation of the present invention, under concept thereof of the present invention, all belong to the scope of protection of present invention to the simple modifications of prescription of the present invention and preparation method.

The preparation of embodiment 1 Chinese medicine oral liquid

Ten gomi herbs more than [method for making], except Mentholum, decoct with water three times, first time adds water 7L decoct 1 hour, and second time adds water 6L decoct 45 minutes, and third time adds water 5L decoct 30 minutes, decocting liquid filters respectively, merges, is concentrated into 1000ml, add the Mentholum with 1ml dissolve with ethanol, mixing, filters, by every bottled 250ml embedding, sterilizing, to obtain final product.

Embodiment 2 Chinese medicine oral liquid is to the Ureteral Calculus of pharynx foreign body sensation disease patient

In pharynx foreign body sensation disease patient 192 example of Qingdao Municipal Hospital outpatient clinic, all make a definite diagnosis after throat, nose, ear, eye and cervical region inspection, the modal main suit of outpatient service is " foreign bodies in the larynx sense ", and other have, and throat blocks sense, food stops throat's sense, expectorant sticks sense or worm climbs the symptoms such as sense.In 192 routine patients diagnosed, man 87 example, female 105 example; 20 ~ 63 years old age, year mean age (35 ± 6.8); Not etc., average course of disease is not (1.6 ± 0.3) individual month for the course of disease 1 month to 2 years.Be divided into matched group (96 example) and test group (96 example) at random by medical sequencing, between two groups, the equal not statistically significant of the difference of sex, age, the course of disease, has comparability.

Matched group adopts oryzanol 20mg and vitamin B ₆20mg takes, every day 3 times, one after each meal.And the food that avoids pungent food, Folium Camelliae sinensis, coffee etc. have the food stimulating excitation.Outpatient service gives psychological counseling, and advises patient to note striking a proper balance between work and rest, and distracts attention.Advise drug withdrawal in 1 week after general transference cure, take 2 ~ 4 weeks courses for the treatment of.Test group adds Chinese medicine oral liquid (obtaining by the prescription of the embodiment of the present invention 1 and method for making preparation) on the basis for the treatment of of control group, a 80ml, every day 3 times, after meal half an hour decoction being taken warmly, take 2 ~ 4 weeks courses for the treatment of.After treatment terminates, carry out efficacy evaluation by following standard: fully recover for subjective symptoms disappears, foreign sense, without uncomfortable in chest, heaves a deep sigh, and emotion is happy; Effectively obviously alleviate for subjective symptoms, without uncomfortable in chest, heave a deep sigh, emotion is clearly better; Effectively for subjective symptoms alleviates, slightly uncomfortable in chest, emotion is general; Invalid still exist for throat's paresthesia, accompanies uncomfortable in chest, heave a deep sigh, depressed.Total effective rate=(recovery from illness number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%.

Clinical efficacy statistical result according to table 1 can be found out, two groups of patients are after treatment, and test group total effective rate is 96.9%; Matched group total effective rate is 59.4%, and the evident in efficacy of test group is better than matched group, and this illustrates and uses general conventional therapy to add that Chinese medicine oral liquid of the present invention is obviously better than the alone general conventional therapy of matched group.

The therapeutic effect of table 1 test group and matched group compares

Claims (8)

1. treat the pharmaceutical composition of disease of pharynx for one kind, it is characterized in that, described pharmaceutical composition by following weight portion traditional Chinese medicinal material raw materials through decocting extract be prepared from: Cortex Moutan 32-50 part, Mentholum 0.1-0.5 part, Flos Chrysanthemi 32-50 part, Radix Platycodonis 32-50 part, Rhizoma Pinelliae Preparata 20-30 part, Radix Rehmanniae 40-56 part, Radix Scrophulariae 40-56 part, Periostracum Cicadae 20-30 part, Radix Clematidis 32-50 part, Radix Salviae Miltiorrhizae 40-56 part, Radix Angelicae Sinensis 40-56 part, Radix Ophiopogonis 40-56 part, Fructus Schisandrae Chinensis 32-50 part, Poria 32-50 part, Radix Glycyrrhizae 20-30 part.

2. treat the pharmaceutical composition of disease of pharynx according to claim 1, it is characterized in that, described pharmaceutical composition by following weight portion traditional Chinese medicinal material raw materials through decocting extract be prepared from: Cortex Moutan 38-42 part, Mentholum 0.1-0.3 part, Flos Chrysanthemi 38-42 part, Radix Platycodonis 38-42 part, Rhizoma Pinelliae Preparata 23-25 part, Radix Rehmanniae 46-50 part, Radix Scrophulariae 46-50 part, Periostracum Cicadae 23-25 part, Radix Clematidis 38-42 part, Radix Salviae Miltiorrhizae 46-50 part, Radix Angelicae Sinensis 46-50 part, Radix Ophiopogonis 46-50 part, Fructus Schisandrae Chinensis 38-42 part, Poria 38-42 part, Radix Glycyrrhizae 23-25 part.

3. treat the pharmaceutical composition of disease of pharynx according to claim 1, it is characterized in that, described pharmaceutical composition is prepared from through decocting extraction by the traditional Chinese medicinal material raw materials of following weight portion: Cortex Moutan 40 parts, Mentholum 0.2 part, Flos Chrysanthemi 40 parts, Radix Platycodonis 40 parts, Rhizoma Pinelliae Preparata 24 parts, Radix Rehmanniae 48 parts, Radix Scrophulariae 48 parts, Periostracum Cicadae 24 parts, Radix Clematidis 40 parts, Radix Salviae Miltiorrhizae 48 parts, Radix Angelicae Sinensis 48 parts, Radix Ophiopogonis 48 parts, Fructus Schisandrae Chinensis 40 parts, 40 parts, Poria, 24 parts, Radix Glycyrrhizae.

4. according to claim 1 or 2 or 3, treat the pharmaceutical composition of disease of pharynx, it is characterized in that, described pharmaceutical composition is oral liquid, tablet, granule, capsule or pill.

5. treat the preparation method of the oral liquid of disease of pharynx according to claim 4 for one kind, it is characterized in that the method comprises the steps: except Mentholum, take other medical material to merge, decoct with water 1-4 time, decocting liquid filters, add the Mentholum with dissolve with ethanol, mixing, filters, embedding, sterilizing, to obtain final product.

6. treat the preparation method of the oral liquid of disease of pharynx according to claim 5, it is characterized in that, other described medical material decocts with water 3 times after merging, first time 0.8-1.2 hour, second time 0.6-0.8 hour, third time 0.4-0.6 hour.

7. claim 1 or the pharmaceutical composition described in 2 or 3 application in the medicine of preparation treatment disease of pharynx.

8. application according to claim 7, is characterized in that, described disease of pharynx comprises dry pharynx pharyngalgia, dysphagia and pharynx foreign body sensation disease.