CN104547512B - A kind of pharmaceutical composition for treating disease of pharynx and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating disease of pharynx and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition for treating disease of pharynx and preparation method thereof, said composition is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through decocting extraction：32 50 parts of moutan bark, 0.1 0.5 parts of menthol, 32 50 parts of chrysanthemum, 32 50 parts of balloonflower root, 20 30 parts of the tuber of pinellia processed, 40 56 parts of glutinous rehmannia, 40 56 parts of radix scrophulariae, 20 30 parts of cicada slough, 32 50 parts of the root of Chinese clematis, 40 56 parts of the red sage root, 40 56 parts of Radix Angelicae Sinensis, 40 56 parts of the tuber of dwarf lilyturf, 32 50 parts of the fruit of Chinese magnoliavine, 32 50 parts of Poria cocos, 20 30 parts of radix glycyrrhizae.The medicine is evident in efficacy, safe, while treatment cost is low, is used suitable for medical condition in general basic unit clinical treatment.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of pharmaceutical composition for treating disease of pharynx and its preparation side
Method.
Background technology
Disease of pharynx includes pharyngalgia dry throat, pharyngeal scorching hot, a series of diseases such as dysphagia, pharynx foreign body sensation disease.Swallow foreign matter
Feel disease, also known as pharyngoneurosis, the traditional Chinese medical science claims " globus hysteriocus ", and referring to pharyngeal or bottleneck throat has foreign body sensation, obstruction sense, constriction, tightly
Beam sense etc., one group of neural body syndrome of spirit that self-induction unsmooth breath, collar can not link closely.Be with swallow it is relevant, but
One group of pharynx organ disease of these sensations and Without dysphagia is had no when feed and drinking-water, can also pass through the reflection and conduction of nerve
Effect makes pharyngeal generation abnormal sensory.Pharyngeal nerve is very abundant, and pharynx rear wall has pharyngeal plexus, contains vagus nerve, glossopharyngeal nerve, pair
Nerve, cervical sympathetic nerve branch and trigeminal neuralgia branch.It is to block throat like soft thing to swallow the most common main suit of foreign body sensation disease, but not
Feed is influenceed, can not swallow, that tells does not go out.Often with emotional change and weight differs, be often accompanied by it is uncomfortable in chest heave a deep sigh, but toposcopy sun
Property sign is few, and secretion is few, and tongue nature is light red, thin white fur of tongue.This sick generation can be using local factors such as pharyngeal, oesophaguses as trigger
Point or trigger area, some inappreciable factors can be stimulated in the sensory nerve ending of excited hyperfunction state, aggravate foreign body sensation,
So as to form certain vicious circle.
Doctor trained in Western medicine quite feels intractable in terms of this disease is treated, indefinite mainly due to this sick pathogenesis.The traditional Chinese medical science think it is more because
Feelings will is not smooth, stagnation of liver qi, and mechanism of qi, which rises, to be sent out not normal, cause dysfunction of the spleen in transportation, accumulatively wet raise phlegm, sick in non-return larynx；Its belong to it is invisible it
Phlegm, occurs without the disease of expectoration, and it is light during symptom with emotional change when weight.《Synopsis Golden Chamber》In it is often main with " banxia houpu decoction "
It.
The content of the invention
In view of inherent advantage existing for Chinese traditional treatment disease of pharynx, it is an object of the invention to by the big of drug component
Amount screening, restructuring, attempt, further through a large amount of clinical experimental studies, so as to provide a kind of drug regimen for treating disease of pharynx
Thing and preparation method thereof.
The object of the present invention is achieved like this：
A kind of pharmaceutical composition for treating disease of pharynx, the pharmaceutical composition is by the traditional Chinese medicinal material raw materials of following parts by weight through water
Pan-fried extraction is prepared：Moutan bark 32-50 parts, menthol 0.1-0.5 parts, chrysanthemum 32-50 parts, balloonflower root 32-50 parts, the tuber of pinellia processed
20-30 parts, glutinous rehmannia 40-56 parts, radix scrophulariae 40-56 parts, cicada slough 20-30 parts, root of Chinese clematis 32-50 parts, red sage root 40-56 parts, Radix Angelicae Sinensis 40-
56 parts, tuber of dwarf lilyturf 40-56 part, fruit of Chinese magnoliavine 32-50 parts, Poria cocos 32-50 parts, radix glycyrrhizae 20-30 parts.
Preferably, the pharmaceutical composition of above-mentioned treatment disease of pharynx, it is by the traditional Chinese medicinal material raw materials of following parts by weight through decocting
Extraction is prepared：Moutan bark 38-42 parts, menthol 0.1-0.3 parts, chrysanthemum 38-42 parts, balloonflower root 38-42 parts, tuber of pinellia 23- processed
25 parts, glutinous rehmannia 46-50 parts, radix scrophulariae 46-50 parts, cicada slough 23-25 parts, root of Chinese clematis 38-42 parts, red sage root 46-50 parts, Radix Angelicae Sinensis 46-50
Part, tuber of dwarf lilyturf 46-50 part, fruit of Chinese magnoliavine 38-42 parts, Poria cocos 38-42 parts, radix glycyrrhizae 23-25 parts.
In the most preferred embodiment of the present invention, the pharmaceutical composition of above-mentioned treatment disease of pharynx is by following weight
The traditional Chinese medicinal material raw materials of part are prepared through decocting extraction：It is prepared by the Chinese medicine of following parts by weight：40 parts of moutan bark, peppermint
0.2 part of brain, 40 parts of chrysanthemum, 40 parts of balloonflower root, 24 parts of the tuber of pinellia processed, 48 parts of glutinous rehmannia, 48 parts of radix scrophulariae, 24 parts of cicada slough, 40 parts of the root of Chinese clematis, pellet
48 parts of ginseng, 48 parts of Radix Angelicae Sinensis, 48 parts of the tuber of dwarf lilyturf, 40 parts of the fruit of Chinese magnoliavine, 40 parts of Poria cocos, 24 parts of radix glycyrrhizae.
Still further preferably, the pharmaceutical composition of described treatment disease of pharynx is oral liquid, granule, tablet, ball
Agent and capsule.Can be by traditional Chinese medicinal material raw materials after decocting extraction is prepared into Chinese medical extract and adds auxiliary material, according to this area
Common process be prepared into oral liquid, granule, tablet or capsule.
Present invention also offers the preparation method of the oral liquid of above-mentioned treatment disease of pharynx, this method comprises the following steps：
In addition to menthol, weigh other medicinal materials and merge, add water to cook 1-4 times, decocting liquid filtration, the menthol that addition is dissolved with ethanol, mix
It is even, filtration, embedding, sterilizing, produce.
Preferably, the preparation method of the oral liquid of disease of pharynx is treated as described above, wherein described other medicinal materials merge
After add water to cook 3 times, hour first time 0.8-1.2, second of 0.6-0.8 hour, third time 0.4-0.6 hours.
Found by clinical experimental study, the pharmaceutical composition nourishing Yin and clearing heat being prepared by above-mentioned Chinese medicine, blood-nourishing is driven
Wind, having the effect of notable in terms for the treatment of disease of pharynx, treated effect is up to more than 95%.Therefore, of the invention second
Purpose is to provide a kind of new pharmaceutical use, i.e., above-mentioned pharmaceutical composition answering in the medicine for preparing treatment disease of pharynx
With.Preferably, described disease of pharynx includes dry throat pharyngalgia, dysphagia and pharynx foreign body sensation disease.
According to the historical records of Chinese medicine, the traditional Chinese medicinal material raw materials selected by the present invention have following pharmacological activity and function master
Control：
Moutan bark：From ranunculaceae peony Paeonia suffruticosa Andr. dry root skin.Heat-clearing is cool
Blood is promoting blood circulation and removing blood stasis；For febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter wound
Bitterly.
Menthol is the cyclic alcohol of a kind of saturation extracted in labiate peppermint herb, character be colourless needles or
Prism-shaped crystallizes or white crystalline powder.Dispelling wind；Heat-clearing；Main anemopyretic cold；Headache；Hot eyes；Abscess of throat；Dentalgia；Skin
Itch.
Chrysanthemum：The effect of with dispelling wind, heat-clearing, improving eyesight, removing toxic substances；Primary treatment headache, dizziness, hot eyes, ambition dysphoria with smothery sensation, malignant boil
The diseases such as sore, pyogenic infections.Dry capitulum selected from feverfew chrysanthemum Chrysanthemum morifolium Ramat.
Balloonflower root：Open facilitaing lung gas, eliminating the phlegm apocenosis；Control exogenous cough, abscess of throat, suitable for catching cold, abscess of throat, lung
The diseases such as purulence ulcer, cough vomiting of pus and blood, dysentery phlegm stomachache.From dicotyledon Campanulaceae Campanulaceae balloonflower roots Platycodon
Grandiflorum (Jacq.) A.DC. root.
The tuber of pinellia：It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system head
Bitterly, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus.From aroid tuber of pinellia Pinellia ternata (Thunb.)
Breit. dry tuber.
Glutinous rehmannia：Clearing heat and cooling blood, yin-nourishing, promote the production of body fluid；Hot, the Heat Diabetes for the deep red polydipsia of pyreticosis tongue, yin asthenia generating intrinsic heat, hectic fever due to yin labor,
Spit blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.For the dry of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosa Libosch.
Dry root tuber, also referred to as radix rehmanniae recen.
Radix scrophulariae：Clearing heat and cooling blood, purging intense heat and detonicating, enriching yin；Warm heresy is cured mainly to join the army, cave in pericardium, febrile virulent maculae, consumption of YIN caused by febrile disease,
The deep red polydipsia of tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Selected from dicotyledon Scrophulariaceae
Scrophulariaceae radix scrophulariae Scrophularia ningpoensisHemsl. dry root.
Cicada slough：Wind is dissipated except heat, relieving sore-throat, promoting eruption, moves back screen, spasmolysis；It is mute for anemopyretic cold, pharyngalgia, sound, measles without adequate eruption, wind
Rash itch, cataract, convulsion, lockjaw.From the black grasshopper Cryptotympana pustulata of cicada
Exuviae shell when Fabricius larva sprouts wings.
The root of Chinese clematis：Dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain, dissolving phlegm water, dissipate the hypochondriac lump；Cure mainly stupid numbness of gout, arthralgia pain due to rheumatism, limbs fiber crops
Wood, waist and knee crymodynia, muscle arteries and veins contraction, joint stuffiness, tinea pedis, malaria, a lump in the abdomen causing distension and pain, lockjaw, tonsillitis, all bone sticking swallow.Choosing
With ranunculaceae plant root of Chinese clematis Clematis chinensis Osbeck drying root and rhizome.
The red sage root：From dicotyledon Labiatae Labiatae salvia reds sage root Salvia
MiltiorrhizaBge. dry root.With promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, the work(of nourishing blood and tranquilization
Effect；Irregular menstruation is cured mainly, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Liver and spleen swells
Greatly, angina pectoris.
Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, relax bowel；For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, Amenorrhea pain
Through, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.From umbelliferae angelica Angelica
Sinensis (Oliv.) Diels dry root.
The tuber of dwarf lilyturf：Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire；Disappear for dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, interior heat
Yearningly, vexed insomnia, dry constipation of intestines.Selected from Liliaceae Ophiopogon plant tuber of dwarf lilyturf Ophiopogon Japonicus (Thunb.)
Ker-Gawl. dried root.
The fruit of Chinese magnoliavine：Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming；For empty asthma of coughing long, emission, enuresis frequent micturition, chronic diarrhea
Incessantly, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.
Poria cocos：With Li Shui, the effect of excreting dampness diuresis；Cure mainly difficult urination；Oedema turgor；Phlegm and retained fluid cough is inverse；Vomiting；It is insufficiency of the spleen
Deficiency of food；Diarrhea；Palpitation and restlessness；Insomnia forgetfulness；Seminal emission gonorrhoea.From On Polyporaceae Poria cocos Poria cocos (Schw.)
Wolf dry sclerotia.
Radix glycyrrhizae：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.From for Shuangzi
Leaf plant pulse family Leguminosae radix glycyrrhizaes Glycyrrhiza uralensis Fisch., swollen fruit Radix G.inflata Bat.,
Or glycyrrhiza glabra G.glabra L. root and rhizome.
The pharmaceutical composition of the present invention is using the tuber of pinellia, balloonflower root as monarch drug in a prescription, with Poria cocos, menthol, cicada slough, chrysanthemum, the root of Chinese clematis, pellet
Ginseng, when being classified as ministerial drug, using moutan bark, glutinous rehmannia, radix scrophulariae, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine as adjutant, using radix glycyrrhizae to make medicine, the tuber of pinellia, balloonflower root in side
Share the inverse dissipating bind of drop, clearing lung and eliminating the phlegm；The sweet light excreting dampness invigorating the spleen of Poria cocos, to help tuber of pinellia lowering the adverse-rising QI and eliminating phlegm, menthol, cicada slough, chrysanthemum dispelling wind
Heat-clearing, root of Chinese clematis dehumidifying scattered plot, helps balloonflower root clearing lung and eliminating the phlegm, the red sage root, Radix Angelicae Sinensis promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, helps the tuber of pinellia, balloonflower root altogether altogether
Dissipating bind eliminating the phlegm；Moutan bark, glutinous rehmannia, radix scrophulariae, the tuber of dwarf lilyturf, fruit of Chinese magnoliavine clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, make stomach-Yin to support, and lung Tianjin is able to defeated
Cloth, from holding back, mental disorder disappears the fire of deficiency type certainly；Radix glycyrrhizae not only expelling phlegm and arresting coughing, and can also nourishing the stomach gas, reinforcing earth to generate metal, raw yin edema and fall fire is evil,
Coordinating the drug actions of a prescription, alleviate the adverse reaction of medicine.Compared with prior art, the invention has the advantages that and significantly improving：(1)
Good effect.After pharynx foreign body sensation disease patient takes the medicine composite for curing of the present invention, subjective symptoms disappears, foreign sense, no chest
It is vexed, heave a deep sigh, mood is happy, and treated effect is up to more than 95%.(2) it is safe.Because the medicine of the present invention is using in tradition
It is low that medicinal material is prepared toxicity, adverse reaction is few, and patient medication is safer, and without use antibiotic, will not resist patient
Raw element produces drug resistance.(3) treatment cost is low.Crude drug source is wide, and no rare medicinal herbs, preparation technology is simple, convenient to take, price
It is moderate, used suitable for medical condition in general basic unit clinical treatment.
Embodiment
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the explanation present invention, and
It is not limitation of the present invention, the simple modifications of prescription of the present invention and preparation method is belonged under the concept thereof of the present invention
The scope of protection of present invention.
The preparation of the traditional Chinese medicine oral liquid of embodiment 1
【Preparation method】The gomi herbs of the above ten, except menthol, add water to cook three times, for the first time plus water 7L and decoct 1 hour,
Second plus water 6L is simultaneously decocted 45 minutes, and third time plus water 5L are simultaneously decocted 30 minutes, and decocting liquid filters respectively, merges, is concentrated into
1000ml, the menthol dissolved with 1ml ethanol is added, mixed, filtration, by per bottled 250ml embeddings, sterilizing, produced.
Ureteral Calculus of the traditional Chinese medicine oral liquid of embodiment 2 to pharynx foreign body sensation disease patient
The pharynx foreign body sensation disease patient 192 of outpatient clinic in Qingdao Municipal Hospital, through throat, nose, ear, eye and neck
Made a definite diagnosis after inspection, the most common main suit of outpatient service is " foreign bodies in the larynx sense ", and other have throat's obstruction sense, food to stop throat's sense, phlegm
Stick sense or worm climbs the symptoms such as sense.In 192 patients diagnosed, man 87, female 105；20~63 years old age, average age (35
± 6.8) year；The course of disease 1 month to 2 years, average course of disease are (1.6 ± 0.3) individual month.It is randomly divided into pair by medical sequencing
According to group (96) and test group (96), sex, age, the difference of the course of disease are not statistically significant between two groups, have comparativity.
Control group uses oryzanol 20mg and vitamin B620mg takes, 3 times a day, one after each meal.And the food that avoids pungent food
Thing, tealeaves, coffee etc. have the food for stimulating excitation.Psychological counseling is given in outpatient service, and advises patient to pay attention to striking a proper balance between work and rest, transfer
Notice etc..Advise general symptom to be discontinued within 1 week after disappearing, take the course for the treatment of 2~4 weeks.Test group adds on the basis of control group treatment
Take traditional Chinese medicine oral liquid (being prepared by the prescription and preparation method of the embodiment of the present invention 1), a 80ml, 3 times a day, half an hour after meal
Warmly take, take the course for the treatment of 2~4 weeks.After treatment end, efficacy evaluation is carried out by following standard：Fully recover and disappeared for subjective symptoms, is no different
Thing sense, without uncomfortable in chest, heave a deep sigh, mood is happy；It is effective substantially to mitigate for subjective symptoms, without uncomfortable in chest, heave a deep sigh, mood is clearly better；Have
Imitate and mitigate for subjective symptoms, slightly uncomfortable in chest, mood is general；It is invalid to still suffer from for throat's paresthesia, with uncomfortable in chest, heave a deep sigh, it is depressed.Always
Efficient=(recovery from illness number of cases+effective number of cases+effective number of cases)/total number of cases × 100%.
Two groups of patients can be seen that after treatment according to the clinical efficacy statistical result of table 1, test group total effective rate is
96.9%；Control group total effective rate is 59.4%, is significantly better than control group the effect of test group, and this explanation is controlled with generally conventional
The traditional Chinese medicine oral liquid treated plus the present invention is substantially better than the alone in general conventional therapy of control group.
The test group of table 1 and the therapeutic effect of control group compare
Claims (6)
1. a kind of pharmaceutical composition for treating disease of pharynx, it is different that described disease of pharynx includes dry throat pharyngalgia, dysphagia and pharynx
Thing sense disease, it is characterised in that described pharmaceutical composition is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through decocting extraction：
Moutan bark 38-42 parts, menthol 0.1-0.3 parts, chrysanthemum 38-42 parts, balloonflower root 38-42 parts, tuber of pinellia 23-25 parts processed, glutinous rehmannia 46-50
Part, radix scrophulariae 46-50 parts, cicada slough 23-25 parts, root of Chinese clematis 38-42 parts, red sage root 46-50 parts, Radix Angelicae Sinensis 46-50 parts, tuber of dwarf lilyturf 46-50 part,
Fruit of Chinese magnoliavine 38-42 parts, Poria cocos 38-42 parts, radix glycyrrhizae 23-25 parts.
2. according to claim 1 treat disease of pharynx pharmaceutical composition, it is characterised in that described pharmaceutical composition by
The traditional Chinese medicinal material raw materials of following parts by weight are prepared through decocting extraction：40 parts of moutan bark, 0.2 part of menthol, 40 parts of chrysanthemum, balloonflower root
40 parts, 24 parts of the tuber of pinellia processed, 48 parts of glutinous rehmannia, 48 parts of radix scrophulariae, 24 parts of cicada slough, 40 parts of the root of Chinese clematis, 48 parts of the red sage root, 48 parts of Radix Angelicae Sinensis, the tuber of dwarf lilyturf
48 parts, 40 parts of the fruit of Chinese magnoliavine, 40 parts of Poria cocos, 24 parts of radix glycyrrhizae.
3. the pharmaceutical composition for the treatment of disease of pharynx according to claim 1 or claim 2, it is characterised in that described drug regimen
Thing is oral liquid, tablet, granule, capsule or pill.
A kind of 4. preparation method for the oral liquid for treating disease of pharynx according to claim 3, it is characterised in that this method bag
Include following steps：In addition to menthol, weigh other medicinal materials and merge, add water to cook 1-4 times, decocting liquid filtration, addition is dissolved with ethanol
Menthol, mix, filtration, embedding, sterilizing, produce.
5. the preparation method of the oral liquid of disease of pharynx is treated according to claim 4, it is characterised in that described other medicines
Material adds water to cook 3 times after merging, hour first time 0.8-1.2, second of 0.6-0.8 hour, third time 0.4-0.6 hours.
6. application of the pharmaceutical composition in the medicine for preparing treatment disease of pharynx described in claim 1 or 2, described is pharyngeal
Disease includes dry throat pharyngalgia, dysphagia and pharynx foreign body sensation disease.
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| CN103893527A (en) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | Traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat and preparation method thereof |
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| Title |
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| 玄麦甘桔汤加减治疗慢性咽炎48例;吴小彬;《河南中医学院学报》;20071130;第22卷(第6期);第69-70页，尤其是第69页左栏2治疗方法第2段和右栏4讨论 * |
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