CN104383495A - Drug for treating neural injury caused by chemotherapy and preparation method of drug - Google Patents

Drug for treating neural injury caused by chemotherapy and preparation method of drug Download PDF

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Publication number
CN104383495A
CN104383495A CN201410693397.7A CN201410693397A CN104383495A CN 104383495 A CN104383495 A CN 104383495A CN 201410693397 A CN201410693397 A CN 201410693397A CN 104383495 A CN104383495 A CN 104383495A
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parts
radix
rhizoma
ginseng
herba
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CN201410693397.7A
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唐国永
唐绪坤
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Individual
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Abstract

The invention discloses a drug for treating neural injury caused by chemotherapy. The drug comprises astragalus, angelica sinensis, asarum, sun-dried ginseng, lycopodium clavatum, radix clematidis, radix paeoniae alba, fresh ginger, safflowers, scorpions, earthworms, ginseng, ligusticum wallichii, salvia miltiorrhiza, peach blossoms, fructus trichosanthis, rheum officinale, epimedium herbs, ginkgo leaves, velvet antlers, radix puerariae, stiff silkworms, rhodiola rosea, leeches, tinospora sinensis, mulberry twigs, centipedes, cassia twigs, peach kernels, caulis spatholobi, liquorice, myrobalan, radix aconite kusnezoffii, rhizoma acori graminei, radix aucklandiae, musk, coral, pearls, clove, semen myristicae, agilawood, limonite and magnetite. The effects of regulating qi and blood of the whole body and dredging collaterals to remove the obstruction of qi and blood circulation are achieved according to the principles of dredging in replenishing, replenishing in dredging, replenishing and dredging combination as well as static and dynamic combination, so that the symptoms including coldness, numbness, pain and flaccidity are gradually relieved until disappearing. The drug is capable of promoting blood circulation and ensuring proper downward flow of the blood, has a remarkable effect of promoting blood circulation to remove meridian obstruction for a patient suffering from neural injury caused by chemotherapy and can also take the effects of replenishing qi and enriching the blood as well as strengthening muscles and relieving pain, so that the survival quality of the patient is improved, and the life of the patient is prolonged.

Description

A kind ofly treat medicine of nerve injury caused by chemotherapy and preparation method thereof
Technical field
The present invention relates to a kind of medicine of nerve injury, specifically, relate to and a kind ofly treat medicine of nerve injury caused by chemotherapy and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Along with the prolongation of human survival phase and the raising of medical diagnosis level, tumor has become the first reason of human death at present.China newly send out every year tumor cases be about 3,120,000 example, wherein middle and advanced stage lose surgical engine can patient be about 1,920,000 example.
Clinical treatment Advanced cancers is mainly based on antineoplastic chemotherapy medicine treatment.The nervous lesion that antineoplastic chemotherapy medicine can cause, it is almost present in the middle of all chemotherapeutic drug therapy processes.Serious neurotoxicity usually makes patient face to lower chemotherapeutics the dosage even predicament of drug withdrawal, all may produce infringement to the psychology of patient, physiology and quality of life simultaneously.The neurotoxicity of chemotherapeutics can involve any position of nervous system, cause brain, spinal cord, peripheral nerve and muscle damage, show as the tatanic muscle contraction, leg cramps etc. in the insensitive or paraesthesia in acra and (or) mouth week, acral or jaw portion.
At present, treatment caused by chemotherapeutic medicines nerve injury main method has the perfusion of calcium magnesium, glutamine, glutathion and N-acetylcystein, vitamin E, Neurotropin etc., and above drug effect is slow and curative effect is very micro-.Although also there is the report adopting nerve injury caused by treatment by Chinese herbs chemotherapy, therapeutic effect is also not obvious, and relapse rate is high.
Summary of the invention
The technical problem to be solved in the present invention is for above deficiency, a kind of medicine for the treatment of nerve injury caused by chemotherapy is provided, overcome the side effect of prior art Chinese medicine and western medicine larger, onset is slower, effect is undesirable, the defect that relapse rate is high, adopt nerve injury successful caused by described Drug therapy chemotherapy, relapse rate is low.
Another object of the present invention is to provide a kind of preparation method for the treatment of nerve injury medicine caused by chemotherapy.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of medicine for the treatment of nerve injury caused by chemotherapy, is characterized in that, its curative effect composition comprises the raw material of following weight portion:
Radix Astragali 25-30 part, Radix Angelicae Sinensis 5-10 part, Herba Asari 5-10 part, Radix Ginseng 5-10 part, Herba Lycopodii 30-40 part, Radix Clematidis 30-40 part, Radix Paeoniae Alba 20-30 part, Rhizoma Zingiberis Recens 10-15 part, Flos Carthami 5-10 part, Scorpio 10-15 part, Pheretima 20-25 part, Radix Ginseng (Xinkai River ginseng) 15-20 part, Rhizoma Chuanxiong 10-15 part, Radix Salviae Miltiorrhizae 20-25 part, Flos persicae 20-25 part, Fructus Trichosanthis 20-25 part, Radix Et Rhizoma Rhei 5-10 part, Herba Epimedii 20-25 part, Folium Ginkgo 20-25 part, Cornu Cervi Pantotrichum 5-10 part, Radix Puerariae 20-25 part, Bombyx Batryticatus 10-15 part, Radix Rhodiolae 20-25 part, Hirudo 5-10 part, Herba Lycopodii 20-25 part, Ramulus Mori 20-25 part, Scolopendra 15-20 part, Ramulus Cinnamomi 5-10 part, Semen Persicae 20-25 part, Caulis Spatholobi 10-15 part, Radix Glycyrrhizae 20-25 part, Fructus Chebulae 10-15 part, Radix Aconiti Kusnezoffii 20-25 part, Rhizoma Acori Graminei 20-25 part, Radix Aucklandiae 10-15 part, Moschus 5-10 part, Corallium Japonicum Kishinouye 20-25 part, Margarita 10-15 part, Flos Caryophylli 20-25 part, Semen Myristicae 10-15 part, Lignum Aquilariae Resinatum 20-25 part, Limonitum 5-10 part and Magnetitum 5-10 part.
A kind of prioritization scheme, the curative effect composition of described medicine comprises the raw material of following weight portion: Radix Astragali 25-28 part, Radix Angelicae Sinensis 5-8 part, Herba Asari 5-8 part, Radix Ginseng 5-8 part, Herba Lycopodii 30-35 part, Radix Clematidis 30-35 part, Radix Paeoniae Alba 20-28 part, Rhizoma Zingiberis Recens 10-12 part, Flos Carthami 5-8 part, Scorpio 10-12 part, Pheretima 20-22 part, Radix Ginseng (Xinkai River ginseng) 15-18 part, Rhizoma Chuanxiong 10-12 part, Radix Salviae Miltiorrhizae 20-22 part, Flos persicae 20-22 part, Fructus Trichosanthis 20-22 part, Radix Et Rhizoma Rhei 5-8 part, Herba Epimedii 20-22 part, Folium Ginkgo 20-22 part, Cornu Cervi Pantotrichum 5-8 part, Radix Puerariae 20-22 part, Bombyx Batryticatus 10-12 part, Radix Rhodiolae 20-22 part, Hirudo 5-8 part, Herba Lycopodii 20-22 part, Ramulus Mori 20-22 part, Scolopendra 15-18 part, Ramulus Cinnamomi 5-8 part, Semen Persicae 20-22 part, Caulis Spatholobi 10-12 part, Radix Glycyrrhizae 20-22 part, Fructus Chebulae 10-12 part, Radix Aconiti Kusnezoffii 20-22 part, Rhizoma Acori Graminei 20-22 part, Radix Aucklandiae 10-12 part, Moschus 5-8 part, Corallium Japonicum Kishinouye 20-22 part, Margarita 10-12 part, Flos Caryophylli 20-22 part, Semen Myristicae 10-12 part, Lignum Aquilariae Resinatum 20-22 part, Limonitum 5-8 part and Magnetitum 5-8 part.
A kind of prioritization scheme, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 28 parts, Radix Angelicae Sinensis 9 parts, Herba Asari 5 parts, Radix Ginseng 8 parts, Herba Lycopodii 35 parts, Radix Clematidis 30 parts, the Radix Paeoniae Alba 22 parts, 12 parts, Rhizoma Zingiberis Recens, 10 parts, Flos Carthami, Scorpio 12 parts, Pheretima 20 parts, Radix Ginseng (Xinkai River ginseng) 16 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 25 parts, 24 parts, Flos persicae, Fructus Trichosanthis 22 parts, Radix Et Rhizoma Rhei 6 parts, Herba Epimedii 24 parts, Folium Ginkgo 25 parts, 5 parts, Cornu Cervi Pantotrichum, Radix Puerariae 25 parts, Bombyx Batryticatus 14 parts, Radix Rhodiolae 24 parts, Hirudo 5 parts, Herba Lycopodii 24 parts, Ramulus Mori 24 parts, Scolopendra 17 parts, Ramulus Cinnamomi 6 parts, 23 parts, Semen Persicae, Caulis Spatholobi 13 parts, 24 parts, Radix Glycyrrhizae, Fructus Chebulae 13 parts, Radix Aconiti Kusnezoffii 21 parts, Rhizoma Acori Graminei 23 parts, the Radix Aucklandiae 13 parts, 6 parts, Moschus, 25 parts, Corallium Japonicum Kishinouye, Margarita 15 parts, Flos Caryophylli 24 parts, Semen Myristicae 15 parts, Lignum Aquilariae Resinatum 23 parts, Limonitum 7 parts and Magnetitum 6 parts.
Based on above medicine, its preparation method comprises the following steps:
A, take each raw material respectively according to weight portion;
B, salt, bran Radix Astragali (processed): get after wheat bran makes popular, add astragalus mongholicus tablet and make popular, sieve removes wheat bran, adds saline spray even, dries with low baking temperature;
C, butter Herba Epimedii (processed): get butter, put slow fire heat fused in pot, then poured into by above-mentioned Herba Epimedii silk, fries and mix evenly, take out, spread out, dry in the air cool;
D, Radix Rehmanniae Testa Tritici Bombyx Batryticatus: get the Radix Rehmanniae and add water boil 2 hours, to free in ground water leaching 1 hour, clean and dry, then get Testa Tritici and make popular, add Bombyx Batryticatus, fry to faint yellow, sift out Testa Tritici by Bombyx Batryticatus;
E, Radix Aconiti Kusnezoffii Preparata: get the Radix Aconiti Kusnezoffii of steeping and slightly shine to half-dried, the extract soaking and stirring of decocting together with the Radix Rehmanniae, Rhizoma Gastrodiae, Semen sojae atricolor is even, steam and make for 4 hours, take out to interior nothing from the heart, slightly shine to half-dried, separately distillate in pot and the remaining Radix Rehmanniae, Rhizoma Gastrodiae, decoction of black soybean are merged concentrated, admix in Radix Aconiti Kusnezoffii, run through and use up, section is dried;
Semen Myristicae is wrapped up in f, face: wrapped up one by one by Semen Myristicae with dough sheet, or as water pill parcel 3 ~ 4 layers, flour, drop in the Pulvis Talci of heat and stir, take out when dough cover is coke yellow, the used time peels off face;
G, stewing Fructus Chebulae processed: wrap up in stewing method with face, simmering sallow to dough cover is degree, peels off dough cover, faces the used time and smash.
H, Sucus Chaenomelis wine spray Hirudo: Hirudo is exploded and heaves to sallow in Adeps Sus domestica, sprays appropriate Sucus Chaenomelis and yellow wine while hot, with slow fire to dry, add a small amount of Pericarpium Zanthoxyli and mix taking-up thoroughly;
J, by Radix Angelicae Sinensis, Herba Asari, Radix Ginseng, Herba Lycopodii, Radix Clematidis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Flos Carthami, Scorpio, Pheretima, Radix Ginseng (Xinkai River ginseng), Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Flos persicae, Fructus Trichosanthis, Radix Et Rhizoma Rhei, Folium Ginkgo, Cornu Cervi Pantotrichum, Radix Puerariae, Radix Rhodiolae, Herba Lycopodii, Ramulus Mori, Scolopendra, Ramulus Cinnamomi, Semen Persicae, Caulis Spatholobi, Radix Glycyrrhizae, Rhizoma Acori Graminei, the Radix Aucklandiae, Moschus moschiferous is fragrant, Corallium Japonicum Kishinouye, Margarita, Flos Caryophylli, Lignum Aquilariae Resinatum, Limonitum and salt, bran Radix Astragali (processed), butter Herba Epimedii (processed), Radix Rehmanniae Testa Tritici Bombyx Batryticatus, Radix Aconiti Kusnezoffii Preparata, simmer Fructus Chebulae processed, Sucus Chaenomelis wine spray Hirudo, Semen Myristicae mixing is wrapped up in face, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
K, then by smalls with mud tank sealing after, be embedded in, 1 meter, underground, take out after 2 years;
L, point bag hermetic package.
Caused by treatment chemotherapy, the using method of nerve injury Chinese medicine comprises the following steps:
A, Chinese medicine smalls and the Mel of tempering to be mixed by 1: 1.5, rubbing and ball, every pill 0.3g.
B, one time 30, every day three times is oral.
Extremity are soaked in c, external: take the 30 parts+Herba speranskiae tuberculatae of the medicinal residues after medicinal liquid, 50 parts+dry maxima skin, 10 parts+Radix Aconiti 15 parts and get 1000ml with 1300ml decocting, soak 30min, every day 3 times at every turn.
The neuropathy such as the traditional Chinese medical science is meciless by numb limbs and tense tendons, paraesthesia, the dyskinesia are attributed to arthromyodynia, and therefore caused by chemotherapy, nerve injury belongs to Chinese medical ' arthralgia syndrome ' category.Its pathogenesis is chemotherapy damage healthy energy, and the deficiency of vital energy promotes weak, hematogenous blockage, causes muscle arteries and veins to lose and supports, channels stasis blocking.Control suitable inrigorating qi and promoting blood circulation, disperse blood stasis and dredge collateral.In side, effect that Semen Myristicae has benefiting QI and nourishing blood is wrapped up in Radix Astragali (processed), Radix Angelicae Sinensis, Radix Ginseng, Radix Ginseng, the Radix Paeoniae Alba, Folium Ginkgo, face; Caulis Spatholobi, Herba Asari, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Flos persicae, Radix Puerariae, Radix Rhodiolae, Moschus have the effect of invigorating blood circulation; Hirudo (processed), Ramulus Cinnamomi, Rhizoma Chuanxiong, Flos Carthami, Pheretima, Semen Persicae, Ramulus Mori, Scorpio have effect of removing blood stasis with potent drugs dredging collateral; Cornu Cervi Pantotrichum, Radix Aconiti Kusnezoffii Preparata, Herba Epimedii (processed), Herba Lycopodii, Herba Lycopodii, Bombyx Batryticatus processed and Magnetitum have effect of strengthening the tendons and bones; Radix Clematidis, Scolopendra, Rhizoma Acori Graminei, the Radix Aucklandiae, Limonitum have effect of numbness relieving and pain relieving; Fructus Trichosanthis, Radix Et Rhizoma Rhei, Fructus Chebulae processed have effect of removing pathogenic heat from blood and toxic substance from the body; Corallium Japonicum Kishinouye, Margarita, Flos Caryophylli, Lignum Aquilariae Resinatum warming middle-JIAO for easing the stomach are altogether for making medicine, take a broad view of full side, embody " with lead to for mend ", " with lead to for " principle, get invigorating middle warmer have logical, logical in have benefit, fill out the justice of lean phase Ji, quiet dynamic combination, whole body QI and blood is adjusted reach, ruton numbness is declared, then cool, numb, bitterly, flaccidity gradually delays to disappearing.To invigorate blood circulation conducting blood to flow downwards.
The present invention adopts above technical scheme, has obvious promoting blood circulation to remove obstruction in the collateral effect to patient with nerve damage caused by chemotherapy, simultaneously can vigorate qi and replenish the blood, strong muscle pain relieving effect, thus improve quality of life of patients, extending life, through test, effective percentage reaches more than 87.5%.
Below in conjunction with detailed description of the invention to technical scheme further instruction of the present invention.
Detailed description of the invention
Embodiment 1, a kind of medicine for the treatment of nerve injury caused by chemotherapy, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 30 parts, Radix Angelicae Sinensis 10 parts, Herba Asari 10 parts, Radix Ginseng 10 parts, Herba Lycopodii 40 parts, Radix Clematidis 40 parts, the Radix Paeoniae Alba 30 parts, 15 parts, Rhizoma Zingiberis Recens, 5 parts, Flos Carthami, Scorpio 15 parts, Pheretima 23 parts, Radix Ginseng (Xinkai River ginseng) 20 parts, Rhizoma Chuanxiong 11 parts, Radix Salviae Miltiorrhizae 20 parts, 20 parts, Flos persicae, Fructus Trichosanthis 25 parts, Radix Et Rhizoma Rhei 10 parts, Herba Epimedii 21 parts, Folium Ginkgo 20 parts, 10 parts, Cornu Cervi Pantotrichum, Radix Puerariae 21 parts, Bombyx Batryticatus 10 parts, Radix Rhodiolae 25 parts, Hirudo 10 parts, Herba Lycopodii 25 parts, Ramulus Mori 20 parts, Scolopendra 20 parts, Ramulus Cinnamomi 10 parts, 25 parts, Semen Persicae, Caulis Spatholobi 15 parts, 25 parts, Radix Glycyrrhizae, Fructus Chebulae 15 parts, Radix Aconiti Kusnezoffii 20 parts, Rhizoma Acori Graminei 25 parts, the Radix Aucklandiae 15 parts, 10 parts, Moschus, 20 parts, Corallium Japonicum Kishinouye, Margarita 13 parts, Flos Caryophylli 25 parts, Semen Myristicae 10 parts, Lignum Aquilariae Resinatum 25 parts, Limonitum 10 parts and Magnetitum 10 parts.
Embodiment 2, a kind of medicine for the treatment of nerve injury caused by chemotherapy, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 29 parts, Radix Angelicae Sinensis 5 parts, Herba Asari 6 parts, Radix Ginseng 5 parts, Herba Lycopodii 37 parts, Radix Clematidis 38 parts, the Radix Paeoniae Alba 28 parts, 11 parts, Rhizoma Zingiberis Recens, 7 parts, Flos Carthami, Scorpio 13 parts, Pheretima 24 parts, Radix Ginseng (Xinkai River ginseng) 19 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 24 parts, 23 parts, Flos persicae, Fructus Trichosanthis 24 parts, Radix Et Rhizoma Rhei 7 parts, Herba Epimedii 22 parts, Folium Ginkgo 24 parts, 7 parts, Cornu Cervi Pantotrichum, Radix Puerariae 22 parts, Bombyx Batryticatus 13 parts, Radix Rhodiolae 22 parts, Hirudo 7 parts, Herba Lycopodii 22 parts, Ramulus Mori 25 parts, Scolopendra 18 parts, Ramulus Cinnamomi 10 parts, 22 parts, Semen Persicae, Caulis Spatholobi 12 parts, 23 parts, Radix Glycyrrhizae, Fructus Chebulae 14 parts, Radix Aconiti Kusnezoffii 25 parts, Rhizoma Acori Graminei 22 parts, the Radix Aucklandiae 11 parts, 8 parts, Moschus, 24 parts, Corallium Japonicum Kishinouye, Margarita 12 parts, Flos Caryophylli 20 parts, Semen Myristicae 13 parts, Lignum Aquilariae Resinatum 22 parts, Limonitum 9 parts and Magnetitum 8 parts.
Embodiment 3, a kind of medicine for the treatment of nerve injury caused by chemotherapy, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 26 parts, Radix Angelicae Sinensis 8 parts, Herba Asari 8 parts, Radix Ginseng 6 parts, Herba Lycopodii 30 parts, Radix Clematidis 35 parts, the Radix Paeoniae Alba 20 parts, 10 parts, Rhizoma Zingiberis Recens, 8 parts, Flos Carthami, Scorpio 10 parts, Pheretima 22 parts, Radix Ginseng (Xinkai River ginseng) 15 parts, Rhizoma Chuanxiong 10 parts, Radix Salviae Miltiorrhizae 22 parts, 22 parts, Flos persicae, Fructus Trichosanthis 20 parts, Radix Et Rhizoma Rhei 5 parts, Herba Epimedii 20 parts, Folium Ginkgo 22 parts, 8 parts, Cornu Cervi Pantotrichum, Radix Puerariae 20 parts, Bombyx Batryticatus 12 parts, Radix Rhodiolae 20 parts, Hirudo 8 parts, Herba Lycopodii 20 parts, Ramulus Mori 22 parts, Scolopendra 15 parts, Ramulus Cinnamomi 8 parts, 22 parts, Semen Persicae, Caulis Spatholobi 10 parts, 22 parts, Radix Glycyrrhizae, Fructus Chebulae 10 parts, Radix Aconiti Kusnezoffii 22 parts, Rhizoma Acori Graminei 20 parts, the Radix Aucklandiae 10 parts, 5 parts, Moschus, 22 parts, Corallium Japonicum Kishinouye, Margarita 10 parts, Flos Caryophylli 22 parts, Semen Myristicae 12 parts, Lignum Aquilariae Resinatum 20 parts, Limonitum 5 parts and Magnetitum 5 parts.
Embodiment 4, a kind of medicine for the treatment of nerve injury caused by chemotherapy, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 28 parts, Radix Angelicae Sinensis 9 parts, Herba Asari 5 parts, Radix Ginseng 8 parts, Herba Lycopodii 35 parts, Radix Clematidis 30 parts, the Radix Paeoniae Alba 22 parts, 12 parts, Rhizoma Zingiberis Recens, 10 parts, Flos Carthami, Scorpio 12 parts, Pheretima 20 parts, Radix Ginseng (Xinkai River ginseng) 16 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 25 parts, 24 parts, Flos persicae, Fructus Trichosanthis 22 parts, Radix Et Rhizoma Rhei 6 parts, Herba Epimedii 24 parts, Folium Ginkgo 25 parts, 5 parts, Cornu Cervi Pantotrichum, Radix Puerariae 25 parts, Bombyx Batryticatus 14 parts, Radix Rhodiolae 24 parts, Hirudo 5 parts, Herba Lycopodii 24 parts, Ramulus Mori 24 parts, Scolopendra 17 parts, Ramulus Cinnamomi 6 parts, 23 parts, Semen Persicae, Caulis Spatholobi 13 parts, 24 parts, Radix Glycyrrhizae, Fructus Chebulae 13 parts, Radix Aconiti Kusnezoffii 21 parts, Rhizoma Acori Graminei 23 parts, the Radix Aucklandiae 13 parts, 6 parts, Moschus, 25 parts, Corallium Japonicum Kishinouye, Margarita 15 parts, Flos Caryophylli 24 parts, Semen Myristicae 15 parts, Lignum Aquilariae Resinatum 23 parts, Limonitum 7 parts and Magnetitum 6 parts.
Embodiment 5, a kind of medicine for the treatment of nerve injury caused by chemotherapy, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 25 parts, Radix Angelicae Sinensis 7 parts, Herba Asari 7 parts, Radix Ginseng 7 parts, Herba Lycopodii 32 parts, Radix Clematidis 32 parts, the Radix Paeoniae Alba 25 parts, 14 parts, Rhizoma Zingiberis Recens, 9 parts, Flos Carthami, Scorpio 14 parts, Pheretima 25 parts, Radix Ginseng (Xinkai River ginseng) 18 parts, Rhizoma Chuanxiong 13 parts, Radix Salviae Miltiorrhizae 23 parts, 25 parts, Flos persicae, Fructus Trichosanthis 21 parts, Radix Et Rhizoma Rhei 8 parts, Herba Epimedii 25 parts, Folium Ginkgo 23 parts, 9 parts, Cornu Cervi Pantotrichum, Radix Puerariae 24 parts, Bombyx Batryticatus 15 parts, Radix Rhodiolae 21 parts, Hirudo 9 parts, Herba Lycopodii 23 parts, Ramulus Mori 24 parts, Scolopendra 16 parts, Ramulus Cinnamomi 9 parts, 21 parts, Semen Persicae, Caulis Spatholobi 14 parts, 20 parts, Radix Glycyrrhizae, Fructus Chebulae 12 parts, Radix Aconiti Kusnezoffii 24 parts, Rhizoma Acori Graminei 24 parts, the Radix Aucklandiae 12 parts, 7 parts, Moschus, 23 parts, Corallium Japonicum Kishinouye, Margarita 14 parts, Flos Caryophylli 23 parts, Semen Myristicae 21 parts, Lignum Aquilariae Resinatum 23 parts, Limonitum 8 parts and Magnetitum 7 parts.
The medicine of above five embodiments is prepared according to following steps respectively:
A, take each raw material respectively according to weight portion;
B, salt, bran Radix Astragali (processed): get after wheat bran makes popular, add astragalus mongholicus tablet and make popular, sieve removes wheat bran, adds saline spray even, dries with low baking temperature.(every Radix Astragali 500g, uses Sal 186g, water and wheat bran appropriate)
C, butter Herba Epimedii (processed): get butter, put slow fire heat fused in pot, then poured into by above-mentioned Herba Epimedii silk, fries and mix evenly, take out, spread out, dry in the air cool.(every Herba Epimedii 100kg, uses butter 25kg)
D, Radix Rehmanniae Testa Tritici Bombyx Batryticatus: get the Radix Rehmanniae and add water boil 2 hours, to free in ground water leaching 1 hour, clean and dry, then get Testa Tritici and make popular, add Bombyx Batryticatus, fry to faint yellow, sift out Testa Tritici by Bombyx Batryticatus.(every Bombyx Batryticatus 500g, uses Radix Rehmanniae 30g, Testa Tritici 60g).
E, Radix Aconiti Kusnezoffii Preparata: get the Radix Aconiti Kusnezoffii of steeping and slightly shine to half-dried, the extract soaking and stirring of decocting together with the Radix Rehmanniae, Rhizoma Gastrodiae, Semen sojae atricolor is even, steam and make for 4 hours, take out to interior nothing from the heart, slightly shine to half-dried, separately distillate in pot and the remaining Radix Rehmanniae, Rhizoma Gastrodiae, decoction of black soybean are merged concentrated, admix in Radix Aconiti Kusnezoffii, run through and use up, section is dried.(every Radix Aconiti Kusnezoffii 200kg, uses Radix Rehmanniae 10kg, Rhizoma Gastrodiae 20kg, Semen sojae atricolor 10kg).
Semen Myristicae is wrapped up in f, face: wrapped up one by one by Semen Myristicae with dough sheet, or as water pill parcel 3 ~ 4 layers, flour, drop in the Pulvis Talci of heat and stir, take out when dough cover is coke yellow, the used time peels off face.(every 100 jin of Semen Myristicaes, with 50 jin, flour).
G, stewing Fructus Chebulae processed: wrap up in stewing method with face, simmering sallow to dough cover is degree, peels off dough cover, faces the used time and smash.
H, Sucus Chaenomelis wine spray Hirudo: Hirudo is exploded and heaves to sallow in Adeps Sus domestica, sprays appropriate Sucus Chaenomelis and yellow wine while hot, with slow fire to dry, add a small amount of Pericarpium Zanthoxyli and mix taking-up thoroughly.
J, by Radix Angelicae Sinensis, Herba Asari, Radix Ginseng, Herba Lycopodii, Radix Clematidis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Flos Carthami, Scorpio, Pheretima, Radix Ginseng (Xinkai River ginseng), Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Flos persicae, Fructus Trichosanthis, Radix Et Rhizoma Rhei, Folium Ginkgo, Cornu Cervi Pantotrichum, Radix Puerariae, Radix Rhodiolae, Herba Lycopodii, Ramulus Mori, Scolopendra, Ramulus Cinnamomi, Semen Persicae, Caulis Spatholobi, Radix Glycyrrhizae, Rhizoma Acori Graminei, the Radix Aucklandiae, Moschus moschiferous is fragrant, Corallium Japonicum Kishinouye, Margarita, Flos Caryophylli, Lignum Aquilariae Resinatum, Limonitum and salt, bran Radix Astragali (processed), butter Herba Epimedii (processed), Radix Rehmanniae Testa Tritici Bombyx Batryticatus, Radix Aconiti Kusnezoffii Preparata, simmer Fructus Chebulae processed, Sucus Chaenomelis wine spray Hirudo, Semen Myristicae mixing is wrapped up in face, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
K, then by smalls with mud tank sealing after, be embedded in, 1 meter, underground, take out after 2 years;
L, point bag hermetic package.
Caused by treatment chemotherapy, the using method of nerve injury Chinese medicine comprises the following steps:
A, Chinese medicine smalls and the Mel of tempering to be mixed by 1: 1.5, rubbing and ball, every pill 0.3g.
B, one time 30, every day three times is oral.
Extremity are soaked in c, external: take the 30 parts+Herba speranskiae tuberculatae of the medicinal residues after medicinal liquid, 50 parts+dry maxima skin, 10 parts+Radix Aconiti 15 parts and get 1000ml with 1300ml decocting, soak 30min, every day 3 times at every turn.
Above five embodiment gained medicines are used for the treatment of the test of nerve injury caused by chemotherapy, use efficacy assessment standard is:
Recovery from illness: the transference cures such as the paraesthesia in acra and (or) mouth week, acral muscle cramp.
Effective: the transference cures such as the paraesthesia in acra and (or) mouth week, acral muscle cramp, occasionally there is this symptom.
Effective: the symptoms such as the paraesthesia in acra and (or) mouth week, acral muscle cramp alleviate, and often occur this symptom, but number of times obviously reduce.
Invalid: the symptoms such as the paraesthesia in acra and (or) mouth week, acral muscle cramp are without obvious change.
Patient with nerve damage caused by the 240 routine chemotherapy that year October in July, 2010 to 2014 seeks medical advice, patient condition meets nerve injury diagnostic criteria caused by " Internal Medicine-Oncology " the 3rd edition chemotherapy.240 examples all have application antitumor drug history, man 91 example, female 149 example, age 40-80 year, the course of disease 1 month to 2 years.
Arrange 1 matched group and 5 test group altogether, stochastic averagina distributes patient and treats.Test group 1 uses the Drug therapy of embodiment 1 gained, test group 2 uses the Drug therapy of embodiment 2 gained, test group 3 uses the Drug therapy of embodiment 3 gained, test group 4 uses the Drug therapy of embodiment 4 gained, test group 5 uses the Drug therapy of the embodiment of the present invention 5 gained, and matched group adopts the method treatment of the perfusion of doctor trained in Western medicine calcium magnesium, glutamine, vitamin E, Neurotropin.
The result that test obtains is as following table:
Find out from above data, the medicine of nerve injury caused by gained treatment chemotherapy of the present invention, effective percentage can reach more than 87.5%, and relapse rate is low, and in the embodiment above, embodiment 4 is preferred plan, and cure rate reaches 60%, and effective percentage reaches 95%.
Those skilled in the art will recognize that; above-mentioned detailed description of the invention is exemplary; to enable those skilled in the art better understand content of the present invention; should not be understood as limiting the scope of the invention; as long as according to the improvement that technical solution of the present invention is done; and realize and identical effect of the present invention, all fall into protection scope of the present invention.

Claims (4)

1. treat a medicine for nerve injury caused by chemotherapy, it is characterized in that, its curative effect composition comprises the raw material of following weight portion:
Radix Astragali 25-30 part, Radix Angelicae Sinensis 5-10 part, Herba Asari 5-10 part, Radix Ginseng 5-10 part, Herba Lycopodii 30-40 part, Radix Clematidis 30-40 part, Radix Paeoniae Alba 20-30 part, Rhizoma Zingiberis Recens 10-15 part, Flos Carthami 5-10 part, Scorpio 10-15 part, Pheretima 20-25 part, Radix Ginseng (Xinkai River ginseng) 15-20 part, Rhizoma Chuanxiong 10-15 part, Radix Salviae Miltiorrhizae 20-25 part, Flos persicae 20-25 part, Fructus Trichosanthis 20-25 part, Radix Et Rhizoma Rhei 5-10 part, Herba Epimedii 20-25 part, Folium Ginkgo 20-25 part, Cornu Cervi Pantotrichum 5-10 part, Radix Puerariae 20-25 part, Bombyx Batryticatus 10-15 part, Radix Rhodiolae 20-25 part, Hirudo 5-10 part, Herba Lycopodii 20-25 part, Ramulus Mori 20-25 part, Scolopendra 15-20 part, Ramulus Cinnamomi 5-10 part, Semen Persicae 20-25 part, Caulis Spatholobi 10-15 part, Radix Glycyrrhizae 20-25 part, Fructus Chebulae 10-15 part, Radix Aconiti Kusnezoffii 20-25 part, Rhizoma Acori Graminei 20-25 part, Radix Aucklandiae 10-15 part, Moschus 5-10 part, Corallium Japonicum Kishinouye 20-25 part, Margarita 10-15 part, Flos Caryophylli 20-25 part, Semen Myristicae 10-15 part, Lignum Aquilariae Resinatum 20-25 part, Limonitum 5-10 part and Magnetitum 5-10 part.
2. medicine as claimed in claim 1, it is characterized in that, the curative effect composition of described medicine comprises the raw material of following weight portion: Radix Astragali 25-28 part, Radix Angelicae Sinensis 5-8 part, Herba Asari 5-8 part, Radix Ginseng 5-8 part, Herba Lycopodii 30-35 part, Radix Clematidis 30-35 part, Radix Paeoniae Alba 20-28 part, Rhizoma Zingiberis Recens 10-12 part, Flos Carthami 5-8 part, Scorpio 10-12 part, Pheretima 20-22 part, Radix Ginseng (Xinkai River ginseng) 15-18 part, Rhizoma Chuanxiong 10-12 part, Radix Salviae Miltiorrhizae 20-22 part, Flos persicae 20-22 part, Fructus Trichosanthis 20-22 part, Radix Et Rhizoma Rhei 5-8 part, Herba Epimedii 20-22 part, Folium Ginkgo 20-22 part, Cornu Cervi Pantotrichum 5-8 part, Radix Puerariae 20-22 part, Bombyx Batryticatus 10-12 part, Radix Rhodiolae 20-22 part, Hirudo 5-8 part, Herba Lycopodii 20-22 part, Ramulus Mori 20-22 part, Scolopendra 15-18 part, Ramulus Cinnamomi 5-8 part, Semen Persicae 20-22 part, Caulis Spatholobi 10-12 part, Radix Glycyrrhizae 20-22 part, Fructus Chebulae 10-12 part, Radix Aconiti Kusnezoffii 20-22 part, Rhizoma Acori Graminei 20-22 part, Radix Aucklandiae 10-12 part, Moschus 5-8 part, Corallium Japonicum Kishinouye 20-22 part, Margarita 10-12 part, Flos Caryophylli 20-22 part, Semen Myristicae 10-12 part, Lignum Aquilariae Resinatum 20-22 part, Limonitum 5-8 part and Magnetitum 5-8 part.
3. medicine as claimed in claim 1, it is characterized in that, its curative effect composition comprises the raw material of following weight portion:
The Radix Astragali 28 parts, Radix Angelicae Sinensis 9 parts, Herba Asari 5 parts, Radix Ginseng 8 parts, Herba Lycopodii 35 parts, Radix Clematidis 30 parts, the Radix Paeoniae Alba 22 parts, 12 parts, Rhizoma Zingiberis Recens, 10 parts, Flos Carthami, Scorpio 12 parts, Pheretima 20 parts, Radix Ginseng (Xinkai River ginseng) 16 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 25 parts, 24 parts, Flos persicae, Fructus Trichosanthis 22 parts, Radix Et Rhizoma Rhei 6 parts, Herba Epimedii 24 parts, Folium Ginkgo 25 parts, 5 parts, Cornu Cervi Pantotrichum, Radix Puerariae 25 parts, Bombyx Batryticatus 14 parts, Radix Rhodiolae 24 parts, Hirudo 5 parts, Herba Lycopodii 24 parts, Ramulus Mori 24 parts, Scolopendra 17 parts, Ramulus Cinnamomi 6 parts, 23 parts, Semen Persicae, Caulis Spatholobi 13 parts, 24 parts, Radix Glycyrrhizae, Fructus Chebulae 13 parts, Radix Aconiti Kusnezoffii 21 parts, Rhizoma Acori Graminei 23 parts, the Radix Aucklandiae 13 parts, 6 parts, Moschus, 25 parts, Corallium Japonicum Kishinouye, Margarita 15 parts, Flos Caryophylli 24 parts, Semen Myristicae 15 parts, Lignum Aquilariae Resinatum 23 parts, Limonitum 7 parts and Magnetitum 6 parts.
4. the preparation method of medicine as claimed in claim 1, is characterized in that, comprise the following steps:
A, take each raw material respectively according to weight portion;
B, salt, bran Radix Astragali (processed): get after wheat bran makes popular, add astragalus mongholicus tablet and make popular, sieve removes wheat bran, adds saline spray even, dries with low baking temperature;
C, butter Herba Epimedii (processed): get butter, put slow fire heat fused in pot, then poured into by above-mentioned Herba Epimedii silk, fries and mix evenly, take out, spread out, dry in the air cool;
D, Radix Rehmanniae Testa Tritici Bombyx Batryticatus: get the Radix Rehmanniae and add water boil 2 hours, to free in ground water leaching 1 hour, clean and dry, then get Testa Tritici and make popular, add Bombyx Batryticatus, fry to faint yellow, sift out Testa Tritici by Bombyx Batryticatus;
E, Radix Aconiti Kusnezoffii Preparata: get the Radix Aconiti Kusnezoffii of steeping and slightly shine to half-dried, the extract soaking and stirring of decocting together with the Radix Rehmanniae, Rhizoma Gastrodiae, Semen sojae atricolor is even, steam and make for 4 hours, take out to interior nothing from the heart, slightly shine to half-dried, separately distillate in pot and the remaining Radix Rehmanniae, Rhizoma Gastrodiae, decoction of black soybean are merged concentrated, admix in Radix Aconiti Kusnezoffii, run through and use up, section is dried;
Semen Myristicae is wrapped up in f, face: wrapped up one by one by Semen Myristicae with dough sheet, or as water pill parcel 3 ~ 4 layers, flour, drop in the Pulvis Talci of heat and stir, take out when dough cover is coke yellow, the used time peels off face;
G, stewing Fructus Chebulae processed: wrap up in stewing method with face, simmering sallow to dough cover is degree, peels off dough cover, faces the used time and smash.
H, Sucus Chaenomelis wine spray Hirudo: Hirudo is exploded and heaves to sallow in Adeps Sus domestica, sprays appropriate Sucus Chaenomelis and yellow wine while hot, with slow fire to dry, add a small amount of Pericarpium Zanthoxyli and mix taking-up thoroughly;
J, by Radix Angelicae Sinensis, Herba Asari, Radix Ginseng, Herba Lycopodii, Radix Clematidis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Flos Carthami, Scorpio, Pheretima, Radix Ginseng (Xinkai River ginseng), Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Flos persicae, Fructus Trichosanthis, Radix Et Rhizoma Rhei, Folium Ginkgo, Cornu Cervi Pantotrichum, Radix Puerariae, Radix Rhodiolae, Herba Lycopodii, Ramulus Mori, Scolopendra, Ramulus Cinnamomi, Semen Persicae, Caulis Spatholobi, Radix Glycyrrhizae, Rhizoma Acori Graminei, the Radix Aucklandiae, Moschus moschiferous is fragrant, Corallium Japonicum Kishinouye, Margarita, Flos Caryophylli, Lignum Aquilariae Resinatum, Limonitum and salt, bran Radix Astragali (processed), butter Herba Epimedii (processed), Radix Rehmanniae Testa Tritici Bombyx Batryticatus, Radix Aconiti Kusnezoffii Preparata, simmer Fructus Chebulae processed, Sucus Chaenomelis wine spray Hirudo, Semen Myristicae mixing is wrapped up in face, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
K, then by smalls with mud tank sealing after, be embedded in, 1 meter, underground, take out after 2 years.
CN201410693397.7A 2014-11-15 2014-11-15 Drug for treating neural injury caused by chemotherapy and preparation method of drug Pending CN104383495A (en)

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CN107308498A (en) * 2017-06-23 2017-11-03 武汉康华世纪药业有限公司 A kind of preparation method of composite nano fiber Nerve Scaffold
CN108815194A (en) * 2018-09-11 2018-11-16 四川聚元药业集团有限公司 A kind of frying production method of stir-baked BOMBYX BATRYTICATUS in bran
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CN108853365B (en) * 2018-09-17 2021-05-04 蔺莉 Medicine for preventing and treating peripherial neurotoxicity caused by vincristine
CN112691143A (en) * 2021-02-07 2021-04-23 新乡医学院第一附属医院 A topical Chinese medicinal lotion for preventing and treating peripheral nerve injury caused by chemotherapy, and its preparation method

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Application publication date: 20150304