CN103977256A

CN103977256A - Medicine composition for treating cancer

Info

Publication number: CN103977256A
Application number: CN201410221604.9A
Authority: CN
Inventors: 李绍华
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-23
Filing date: 2014-05-23
Publication date: 2014-08-13

Abstract

The invention discloses a medicine composition for treating cancer. The medicine composition is prepared from the following raw materials in parts by weight: 12-24 parts of cockroach, 12-24 parts of nightshade, 12-24 parts of paniculate swallowwort root, 12-24 parts of Indian strawberry, 12-24 parts of solanum lyratum, 12-24 parts of sapindus mukorossi gaertn root, 12-24 parts of Chinese gooseberry root, 12-24 parts of edible tulip, 12-24 parts of sculellaria barbata, 12-24 parts of selfheal, 12-24 parts of hedyotis diffusa, 12-24 parts of indigo naturalis, 12-24 parts of calomel, 9-21 parts of manyleaf paris rhizome, 9-21 parts of radix semiaquilegiae, 9-21 parts of brucea javanica, 9-21 parts of subprostrate sophora, 9-21 parts of rabdosia rubescens, 9-21 parts of long-noded pit viper, 9-21 parts of thunder god vine, 9-21 parts of radix ophiopogonis, 9-21 parts of borneol, 9-21 parts of salvia miltiorrhiza, 9-21 parts of ligusticum wallichii, 9-21 parts of ginseng and 9-21 parts of monkshood. The medicine composition in the takes the combination of materials as the active ingredients and has good effect on treating cancer and an application thereof.

Description

A kind of pharmaceutical composition for the treatment of cancer

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of cancer.

Background technology

Cancer (Cancer), also claims malignant tumor (Malignant neoplasm), serves as reasons and controls the not normal and disease that causes of growth and proliferation of cell mechanism.Cancerous cell except grow out of control, arround also can local invading, normal structure is even transferred to other parts of health via body-internal-circulation system or lymphsystem.Cancer is the general designation of a large class malignant tumor.The feature of cancerous cell be unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, makes human body produce series of symptoms; Cancerous cell also can be transferred to whole body growth and breeding everywhere, cause that human body is become thin, unable, anemia, inappetence, heating and serious organ function impaired etc.Cancer (malignant tumor) also can disorganize, the 26S Proteasome Structure and Function of organ, causes downright bad hemorrhage concurrent infection, and patient is finally dead due to organ failure.

At present, treatment cancer, doctor trained in Western medicine generally adopts chemotherapy, radiotherapy, and the toxic and side effects that Radiotherapy chemotherapy produces is to human body infringement greatly, patient often can not get satisfied effect, but causes on the contrary the adverse consequencess such as health immunologic hypofunction.For avoiding western medical treatment defect, in China medical circles once someone released the scheme that treats from disorders of blood with herbal composite treatment.Chinese traditional treatment cancer is approved by domestic and international Medical Technologist now widely, the effect of Chinese traditional treatment cancer that a large amount of clinical trials and scientific research are verified.As the patent of invention that the number of opening is CN101214331B, a kind of pharmaceutical composition for the treatment of leukemia or cancer is disclosed, said composition is made up of Herba Ephedrae, Ramulus Cinnamomi, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Poria and Rhizoma Pinelliae Preparatum.To treatment leukemia, gastric cancer, breast carcinoma, uterus carcinoma need not change bone marrow, do not operate on, patient's success rate of early and middle portion reaches more than 95%, particularly Acute Hepatic splenomegaly phosphorus bar chronic myeloid leukemia effect is better, and has no side effect.And for example CN103055255A, discloses a kind of medicine for the treatment of cancer.It forms, is mainly used in treating the cancers such as gastric cancer, esophageal carcinoma, nasopharyngeal carcinoma, breast carcinoma, pulmonary carcinoma, ovarian cancer, rectal cancer, renal carcinoma, skin carcinoma, the brain cancer, lymphatic cancer, laryngeal carcinoma by Oldenlandia diffusa Roxb, Rhizoma Curcumae, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Semen Persicae, the worm that wriggles, Sargassum, Thallus Laminariae (Thallus Eckloniae), astragalus, speckle Meng, joy clam, Scorpio, Carapax Trionycis, Flos Carthami, Rhizoma Sparganii, Hylarana guentheri, flea body, snakeworm, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Flos Genkwa.Current also useful Indigo Naturalis, Calomelas are applied in the research report of cancer, but the traditional Chinese medical science is to have no limits to the research of cancer, develops very necessary for the Traditional Chinese medicine composition of cancer.

Summary of the invention

The technical problem to be solved in the present invention is to provide one and treats the good pharmaceutical composition of cancer effect.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, is made up of the raw material of following weight parts:

Preferably, it is to be made up by weight of following raw materials according:

More preferably, it is to be made up by weight of following raw materials according:

The medically acceptable dosage forms such as the preferred pill of dosage form of pharmaceutical composition of the present invention, tablet, dispersible tablet, their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in preparation treatment cancer drug.

In pharmaceutical composition prescription of the present invention:

Qiang roach--there is removing blood stasis with potent drugs arresting convulsion, pathogenic fire purging counteracting toxic substances, anticancer swollen protein, Lymphocytic leukemia is had to edge activity;

Herba Solani Nigri--there is heat-clearing and toxic substances removing, removing heat from blood suppuration, anticancer swollen;

Radix Cynanchi Paniculati--there is heat-clearing and toxic substances removing, removing heat from blood suppuration, anticancer swollen;

Herba Duchesneae Indicae--there is heat-clearing and toxic substances removing, cooling blood for hemostasis treatment skin ulcer, anticancer swollen;

Herba Solani Lyrati--have that the diarrhea of heat type of disappearing is wet, subduing swelling and detoxicating, anticancer swollen;

The fruit root of washing one's hands--there is heat clearing and blood cooling, detumescence eliminate indigestion, anticancer swollen;

Macaque Radix Persicae--there is heat-clearing and toxic substances removing, removing heat from blood moistening and cleaning throat, anticancer swollen;

Pseudobulbus Cremastrae Seu Pleiones--there is removing toxic substances removing dampness, reducing swelling and alleviating pain, anticancer swollen;

Herba Scutellariae Barbatae--there is heat-clearing and toxic substances removing, dampness removing anticancer swollen;

Spica Prunellae--there is heat-clearing and toxic substances removing, removing heat from blood is soothing the liver;

Herba Hedyotidis Diffusae--there is clearing away heat and cooling blood, change swollen dampness removing;

Indigo Naturalis--there is removing heat from blood arresting convulsion, heat-clearing and toxic substances removing, hemostasia and promoting granulation;

Calomelas--there is removing the necrotic tissue and promoting granulation, evacuation of pus, anticancer;

Rhizoma Paridis--heat-clearing and toxic substances removing, antiasthmatic-antitussive, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., detumescence hemostasis;

Radix Semiaquilegiae--heat clearing away, removing toxic substances, detumescence, eliminating stagnation, diuresis;

Fructus Bruceae--there is removing pathogenic heat from blood and toxic substance from the body, change cancer removing mass, anticancer swollen;

Radix Sophorae Tonkinensis--there is heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, anticancer swollen;

Rabdosia rubescens--there is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, anticancer swollen;

Agkistrodon--there is dredging collateral eliminate indigestion, anticancer swollen;

Radix Tripterygii Wilfordii--there is promoting blood circulation to remove obstruction in the collateral, subduing swelling and detoxicating;

Radix Ophiopogonis--there are removing heat from blood arresting convulsion, clearing heat and moistening lung;

Borneolum Syntheticum--there is coma inducing resuscitation, dredging collateral nerve, granulation promoting;

Radix Salviae Miltiorrhizae--there is promoting the circulation of QI to relieve pain, promotion ideas-straightening, relieving accumulation of pathogens promoting the circulation of blood;

Rhizoma Chuanxiong--there is promoting the circulation of QI to relieve pain, warming the kidney to activate YANG, removing mass;

Radix Ginseng--there is invigorating primordial QI, rescue up reversal sun;

Radix Aconiti Lateralis Preparata--there is yang invigorating wet, rescue contrary return to life from the nether world, solid and gas eliminate indigestion.

Pharmaceutical composition of the present invention is on Indigo Naturalis, the basis of Calomelas as anticancer pharmaceutical composition, add other components, compare simple use Indigo Naturalis, Calomelas, can increase cancerous cell diffusion transfer sexually transmitted disease (STD) is become to inhibitory action, Lymphocytic leukemia is had to edge activity, anticancer cell, has promoting flow of QI and blood, pain relieving blood stasis dispelling evacuation of pus, heat-clearing and toxic substances removing, the detumescence of having one's ideas straightened out, rushes down scorching counteracting toxic substances, removing the necrotic tissue and promoting granulation, reparation entity cytoactive, treating the poisonous disease with poisonous drugs effect.

Pharmaceutical composition of the present invention is to most of cancers such as treatment leukemia, gastric cancer, esophageal carcinoma, nasopharyngeal carcinoma, breast carcinoma, uterus carcinoma, pulmonary carcinoma, ovarian cancer, rectal cancer, renal carcinoma, skin carcinoma, the brain cancer, lymphatic cancer, laryngeal carcinoma, mature preparation process, produce simple, cost is low, easy to use, curative effect experimental results show that effectively through crowd widely.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1

Above-mentioned raw materials is smashed, crossed 80 mesh sieves, add making pellets by mixing medical powder with honey, obtain pill.

Embodiment 2

Above-mentioned raw materials is added to appropriate cane sugar powder, routinely the agent of technique granulation.

Embodiment 3

Above-mentioned raw materials is mixed, pulverized 80 mesh sieves, obtain powder.

Embodiment 4

After above-mentioned raw materials is mixed, smash, cross 80 mesh sieves, add the magnesium stearate adjuvant of conventional amount used, technique is made tablet routinely, 0.5 part/sheet of specification.

Embodiment 5

After above-mentioned raw materials is mixed, smash, cross 80 mesh sieves, pack capsulae vacuus into, make capsule, 0.5 part/.

Experimental example: the inhibitory action of pharmaceutical composition of the present invention to cancerous cell

1, experiment material: pharmaceutical composition prepared by the embodiment of the present invention 3, embodiment 5.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

2, tumor cell line: people's lung source adenocarcinoma cell SPCA-1, Bel7402 Hep part 2 and people's chronic myelogenous leukemia cell K562, use RPMI-1649 culture fluid, 37 DEG C, 5%C0 ₂, relative humidity 100% is cultivated, and attached cell 0.25% trypsinization goes down to posterity.

3, the inhibitory action of method MTT colorimetric method for determining extract to growth of tumour cell.The trophophase cell of taking the logarithm, is mixed with cell suspension, suspension cell 1X10 with fresh RPMI-1640 culture fluid ⁵individual/ml attached cell 0.8X10 ⁵individual/ml.Suspension cell is inoculated in 96 well culture plates after adding respectively variable concentrations Experimental agents; Attached cell is first inoculated in 96 well culture plates, and every hole 90 μ l, add respectively variable concentrations Experimental agents after 24h.Final volume is that every hole 100 μ l and every group are established 3 parallel holes, establishes altogether 4 groups: be subject to reagent group T (culture fluid+cell suspension+variable concentrations is subject to reagent), negative control group N (culture fluid+cell suspension), medicine color matched group TC (culture fluid+variable concentrations is subject to reagent), blank group B (culture fluid+normal saline).Tested concentration is followed successively by 10 μ part/m1,30 μ part/m1,50 μ part/ml.Put 37 DEG C, 5%C0 ₂in incubator, cultivate after 72h, after adding the 10 μ l concussions of MTT solution to mix to every hole, continue to cultivate 4h, add SDS90 μ l to stop cultivating, 37 DEG C are spent the night, then under room temperature, on micro oscillator, shake 10min, microplate reader is measured the absorbance (OD value) at 570nm wavelength place, and experiment repeats 3 times.

Calculate as follows growth inhibition ratio:

Growth inhibition ratio (%)=[(N group OD average-B group OD average)-(T group OD average-TC group OD average)]/[N group OD average-B group OD average] X100%.

4, medicine to the suppression ratio of people's lung source adenocarcinoma cell SPCA-1, Bel7402 Hep part 2 and people's chronic myelogenous leukemia cell K562 the results are shown in Table 1, table 2, table 3.

Table 1: to the suppression ratio result of SPCA-1

Table 2: to the suppression ratio result of Hep part 2

Table 3: to the suppression ratio result of K562

Result shows, pharmaceutical composition prepared by embodiment 3, embodiment 5 is to SPCA-l, Hep part 2, and the propagation of K562 cell all has inhibitory action, and embodiment 5 curative effects are better than embodiment 3.

Clinical effectiveness

For many years, medicine composite for curing leukemia of the present invention and cancer clinical observation 95 examples, all obtain promising result, is now reported as follows:

1, physical data

95 routine patients are all outpatient.Wherein male 51 examples, female's 44 examples; The oldest 73 years old, minimum 24 years old; The course of disease is the longest 3 years, the shortest half a year; Comprise leukemia, gastric cancer, esophageal carcinoma, nasopharyngeal carcinoma, breast carcinoma, uterus carcinoma, pulmonary carcinoma, ovarian cancer, rectal cancer, renal carcinoma, skin carcinoma, the brain cancer, lymphatic cancer, laryngeal carcinoma etc.

2, diagnostic criteria

Western medicine diagnose standard: 1, leukocyte is high; 2, platelet exceedes normal number;

Tcm diagnosis standard: with reference to doctor trained in Western medicine blood examination.

3, criterion of therapeutical effect

Effective: blood routine examination leukocyte recovers normal, and cancerous cell disappears.

Effective: blood routine examination leukocyte normal, cancerous cell reduces.

Invalid: blood routine examination leukocyte is unchanged, cancerous cell is without obviously reducing.

4, therapeutic outcome

Claims

1. a pharmaceutical composition for the treatment of cancer, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

2. the pharmaceutical composition for the treatment of cancer according to claim 1, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

3. the pharmaceutical composition for the treatment of cancer according to claim 1, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment cancer in claim 1-3.