CN104013916A

CN104013916A - Pharmaceutical composition for treating metrocarcinoma

Info

Publication number: CN104013916A
Application number: CN201410279685.8A
Authority: CN
Inventors: 邱福琴
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-20
Filing date: 2014-06-20
Publication date: 2014-09-03

Abstract

The invention discloses a pharmaceutical composition for treating metrocarcinoma. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 12-24 parts of air potato, 12-24 parts of rhizoma sparganii, 12-24 parts of curcuma zedoary, 12-24 parts of alum, 12-24 parts of manyleaf paris rhizome, 12-24 parts of arisaema elephas buchet, 12-24 parts of radix sophorae subprostratae, 12-24 parts of brucea javanica, 12-24 parts of centipede, 9-21 parts of long-noded pit viper, 9-21 parts of indigo naturalis, 9-21 parts of pangolin scale, 9-21 parts of calomel, 9-21 parts of radix notoginseng, 9-21 parts of edible tulip, 9-21 parts of musk, 9-21 parts of rheum officinale and 9-21 parts of safflower carthamus. The invention discloses a pharmaceutical composition with relatively good effect on treating metrocarcinoma and an application thereof.

Description

A kind of pharmaceutical composition for the treatment of uterus carcinoma

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of uterus carcinoma.

Background technology

Cancer (Cancer), also claims malignant tumor (Malignant neoplasm), serves as reasons and controls the not normal and disease that causes of growth and proliferation of cell mechanism.Cancerous cell except grow out of control, arround also can local invading, normal structure is even transferred to other parts of health via body-internal-circulation system or lymphsystem.Cancer is the general designation of a large class malignant tumor.The feature of cancerous cell be unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, makes human body produce series of symptoms; Cancerous cell also can be transferred to whole body growth and breeding everywhere, cause that human body is become thin, unable, anemia, inappetence, heating and serious organ function impaired etc.Cancer (malignant tumor) also can disorganize, the 26S Proteasome Structure and Function of organ, causes downright bad hemorrhage concurrent infection, and patient is finally dead due to organ failure.

Uterus carcinoma (carcinoma of uterus, metrocarcinoma) cervical cancer is one of modal malignant tumor of gynecological, refer to the malignant tumor that occurs in utero vaginal portion and cervical canal, the cancer that the most common intrauterine occurs is carcinoma of endometrium and cervical cancer.In the world, approximately there are every year more than 20 ten thousand women to die from cervical cancer.In developing country, cervical cancer belongs to common multiple gynecological tumor, the seniority among brothers and sisters umber one.The annual newfound case of China is 13.15 ten thousand, and the area that mortality rate is the highest is Shanxi, and minimum is Tibet.Total trend be rural area higher than city, mountain area is higher than Plain.

At present, treatment cancer, doctor trained in Western medicine generally adopts operation, chemotherapy, radiotherapy, and the toxic and side effects that Radiotherapy chemotherapy produces is to human body infringement greatly, patient often can not get satisfied effect, but causes on the contrary the adverse consequencess such as health immunologic hypofunction.In early days, cancer can reach by operation the object of healing in conjunction with the method for Chinese medicine; But arrived the late period of cancer, operation method has been difficult to reach the object of healing, can only treat by chemicotherapy or with Chinese medicine.For avoiding western medical treatment defect, in China medical circles once someone released the scheme that treats with herbal composite treatment cancer.Chinese traditional treatment cancer is approved by domestic and international Medical Technologist now widely, the effect of Chinese traditional treatment cancer that a large amount of clinical trials and scientific research are verified.As the patent of invention of Chinese patent CN102389557B, a kind of Chinese medicine composition, Chinese medicine medicine ball and application for the treatment of uterus carcinoma disclosed, described Chinese medicine composition is made up of Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Radix Trichosanthis, Rhizoma Curcumae Longae, Cortex Phellodendri, thick fore-telling, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Radix Glycyrrhizae.Current also useful Indigo Naturalis, Calomelas are applied in the research report of cancer, but the traditional Chinese medical science is to have no limits to the research of cancer, develops very necessary for the Traditional Chinese medicine composition of cancer.

Summary of the invention

The technical problem to be solved in the present invention is to provide one and treats the good pharmaceutical composition of uterus carcinoma effect.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, is made up of the raw material of following weight parts:

Preferably, it is to be made up by weight of following raw materials according:

More preferably, it is to be made up by weight of following raw materials according:

The medically acceptable dosage forms such as the preferred pill of dosage form of pharmaceutical composition of the present invention, tablet, dispersible tablet, their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in preparation treatment uterus carcinoma medicine.

In pharmaceutical composition prescription of the present invention:

Rhizoma Dioscoreae Bulbiferae--there is suppuration, eliminating stagnation, detumescence antitumaous effect;

Rhizoma Sparganii--there is promoting flow of QI and blood, the stagnant effect of removing food stagnancyization;

Rhizoma Curcumae--there is circulation of qi promoting removing blood stasis, removing food stagnancy analgesic effect;

Alumen--the hot dispersing tumor of Ju You Cheongju, antitumor action;

Rhizoma Paridis--there is clearing away heat to alleviate pain, antitumor action;

Rhizoma Arisaematis--there is dispersing swelling and dissipating binds, antitumaous effect;

Radix Sophorae Tonkinensis--there is detumescence antitumaous effect;

Fructus Bruceae--there is removing pathogenic heat from blood and toxic substance from the body, change tumor effect;

Scolopendra--there is tuberculosis, dispersing tumor resistant effect;

Agkistrodon--there is dredging collateral eliminate indigestion, antitumaous effect;

Indigo Naturalis--there is purging fire and cooling blood, antitumaous effect;

Squama Manis--there is the scrofula of stimulating the menstrual flow disease, the skin ulcer that disappears effect;

Calomelas--there is removing the necrotic tissue and promoting granulation, the anticancer swollen effect of evacuation of pus;

Moschus--there is the coma of having one's ideas straightened out, refreshment, the anticancer swollen effect of evacuation of pus;

Pseudobulbus Cremastrae Seu Pleiones--Ju You Cheongju thermal detoxification, the pain that disappears antitumaous effect;

Radix Notoginseng--have invigorate blood circulation, removing heat from blood, detumescenceization become silted up, analgesic therapy effect;

Radix Et Rhizoma Rhei--have and attack under long-pending rushing down, removing heat from blood and promoting blood circulation effect;

Flos Carthami--there is promoting blood circulation to remove obstruction in the collateral, change the bolt silt effect that disappears.

Pharmaceutical composition of the present invention is on Indigo Naturalis, the basis of Calomelas as anticancer pharmaceutical composition; add other components; compare simple use Indigo Naturalis, Calomelas; there is removing the necrotic tissue and promoting granulation, anticancer toxin expelling, dispersing tumorization silt; softening the hard mass evacuation of pus, protects each organ not destroyed by cancerous cell fast, improves red blood cell and platelet immunologic function; treating the poisonous disease with poisonous drugs, the effect of for cancerization corruption.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1

Above-mentioned raw materials is smashed, crossed 80 mesh sieves, add making pellets by mixing medical powder with honey, obtain pill.

Embodiment 2

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), add appropriate cane sugar powder, routinely the agent of technique granulation.

Embodiment 3

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), the magnesium stearate adjuvant that adds conventional amount used, technique is made tablet routinely, 0.5 part/sheet of specification.

Embodiment 4

Above-mentioned raw materials is mixed, pulverized 80 mesh sieves, obtain powder.

Embodiment 5

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), add the magnesium stearate adjuvant of conventional amount used, make capsule, 0.5g/ grain.

Experimental example: the inhibitory action of pharmaceutical composition of the present invention to cancerous cell

1, experiment material: pharmaceutical composition prepared by the embodiment of the present invention 3, embodiment 5.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

2, tumor cell line: cervical cancer cell HeLa, use RPMI-1649 culture fluid, 37 DEG C, 5%C0 ₂, relative humidity 100% is cultivated, and attached cell 0.25% trypsinization goes down to posterity.

3, the inhibitory action of method MTT colorimetric method for determining extract to growth of tumour cell.The trophophase cell of taking the logarithm, is mixed with cell suspension, suspension cell 1X10 with fresh RPMI-1640 culture fluid ⁵individual/ml attached cell 0.8X10 ⁵individual/ml.Suspension cell is inoculated in 96 well culture plates after adding respectively variable concentrations Experimental agents; Attached cell is first inoculated in 96 well culture plates, and every hole 90 μ l, add respectively variable concentrations Experimental agents after 24h.Final volume is that every hole 100 μ l and every group are established 3 parallel holes, establishes altogether 4 groups: be subject to reagent group T (culture fluid+cell suspension+variable concentrations is subject to reagent), negative control group N (culture fluid+cell suspension), medicine color matched group TC (culture fluid+variable concentrations is subject to reagent), blank group B (culture fluid+normal saline).Tested concentration is followed successively by 10 μ part/m1,30 μ part/m1,50 μ part/ml.Put 37 DEG C, in 5%C02 incubator, cultivate after 72h, after adding the 10 μ l concussions of MTT solution to mix to every hole, continue to cultivate 4h, add SDS90 μ l to stop cultivating, 37 DEG C are spent the night, and then under room temperature, on micro oscillator, shake 10min, microplate reader is measured the absorbance (OD value) at 570nm wavelength place, and experiment repeats 3 times.

Calculate as follows growth inhibition ratio:

Growth inhibition ratio (%)=[(N group OD average-B group OD average)-(T group OD average-TC group OD average)]/[N group OD average-B group OD average] X100%.

4, medicine the results are shown in Table 1 to the suppression ratio of cervical cancer cell HeLa.

Table 1: to the suppression ratio result of HeLa

Result shows, pharmaceutical composition prepared by embodiment 3, embodiment 5 has inhibitory action to the propagation of HeLa cell, and embodiment 5 curative effects are better than embodiment 3.

Clinical effectiveness

For many years, medicine composite for curing uterus carcinoma of the present invention clinical observation, all obtains promising result, is now reported as follows:

1, physical data

87 routine patients all hitch institute and out-patient, and the oldest 78 years old, minimum 36 years old; The course of disease is the longest 3 years, the shortest half a year.

2, diagnostic criteria

Selecting tcm diagnosis uterus carcinoma is standard: limb is soft unable, deficient serious, and lower abdomen tenesmus, suppresses swollen pain, the visible tumor of uterus CT.As above symptom, can make a definite diagnosis.

Take the capsule that the embodiment of the present invention 5 obtains, every day 3 times, each 2,30 days courses for the treatment of, take 3 courses for the treatment of.

3, criterion of therapeutical effect

Effective: body constitution strengthens, and extremity are strong, lower abdomen is uncomfortable obviously to be alleviated, and CT shows that uterus tumor tumor body dwindles, and newborn tumor is not found at other position.

Effective: with it energetically, lower abdomen discomfort is alleviated to some extent, uterus tumor tumor body has no growth, and newborn tumor is not found at other position.

Invalid: disease is unchanged, uterus tumor tumor body increases, or newborn tumor is found at other position.

4, therapeutic outcome

Claims

1. a pharmaceutical composition for the treatment of uterus carcinoma, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

2. the pharmaceutical composition for the treatment of uterus carcinoma according to claim 1, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

3. the pharmaceutical composition for the treatment of uterus carcinoma according to claim 1, is characterized in that: this pharmaceutical composition is to be made up of the raw material of following weight parts:

4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment uterus carcinoma in claim 1-3.