CN104383148A - Phlegm dissolving and stasis removing powder for treating esophagus cancer and preparation - Google Patents
Phlegm dissolving and stasis removing powder for treating esophagus cancer and preparation Download PDFInfo
- Publication number
- CN104383148A CN104383148A CN201410760918.6A CN201410760918A CN104383148A CN 104383148 A CN104383148 A CN 104383148A CN 201410760918 A CN201410760918 A CN 201410760918A CN 104383148 A CN104383148 A CN 104383148A
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- CN
- China
- Prior art keywords
- powder
- treatment
- esophageal carcinoma
- preparation
- fructus bruceae
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Abstract
The invention discloses a phlegm dissolving and stasis removing powder for treating esophagus cancer. The powder is mainly prepared from the following raw materials in parts by weight: 10 to 20 of white silkworm, 2 to 4 of realgar, 10 to 20 of scorpion, 10 to 20 of excrementum pteropi, 4 to 6 of periwinkle, 5 to 10 of pardanthus, 9 to 15 of fructus bruceae, 6 to 9 of natural indigo, 4 to 9 of air bladder, and a defined amount of fresh dog gall. According to the invention, all the raw materials are traditional Chinese medicinal plants and have no toxic or side effects; the prescription completely conforms to the principle of traditional Chinese medicine; the medicine has the effects of dissolving phlegm, dispersing blood stasis, regulating the flow of qi, relieving pains, warming the spleen and invigorating stomach, is obvious in clinical test and curative effect and can effectively inhibit the activity of cancer cells.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma and preparation method thereof.
Background technology
The esophageal carcinoma means the malignant change formed by esophagus squameous epithelium or epithelioglandular paraplasm.Its development is general through stages such as epithelial dysplasia, cancer in situ, infiltrating carcinomas.Esophagus squameous epithelial dysplasia is the important precancerous lesion of the esophageal carcinoma, generally needs several years even more than ten years by atypical hyperplasia to canceration.Therefore, if some esophageal carcinoma early discoverys can be cured completely.For swallow smooth or have the patient of foreign body sensation should row gastroscopy as early as possible to find the early stage esophageal carcinoma or precancerous lesion.The esophageal carcinoma is the common malignant tumor of the mankind, accounts for more than 90% of esophageal neoplasm, is only second to gastric cancer and occupies the 2nd in whole mortality of malignant tumors retrospective survey.According to estimates the whole world every year nearly 200,000 people die from the esophageal carcinoma, be to one of very harmful modal malignant tumor of the life and health of the people.Clinical symptoms shows because of the difference of the many factors such as disease, pathomorphism, body reaction and is not quite similar, and early esophageal cancer principal character symptom is uncomfortable after breastbone or swallows pain; Mid-term, the classical symptom of esophageal carcinoma was Progressive symmetric erythrokeratodermia dysphagia; The esophageal lesion section of advanced esophageal cancer has ulcer, inflammation or Invasion of cancer, then produce after breastbone or the symptom of back persistence dull pain.Treatment for esophageal carcinoma has operation, chemotherapy, and the methods such as treatment by Chinese herbs and electrochemistry intervention+particle support, according to the type of esophageal carcinoma, can select different treatment meanss.The treatment that the esophageal carcinoma is early stage is advised more to the Comprehensive Treatment mode adopting operation, chemicotherapy, Chinese medicine to combine, middle and advanced stage will adopt traditional Chinese medical science expectant treatment.The traditional Chinese medical science is thought, the basic of esophageal carcinoma pathogenesis is yang-energy weakness, and body function declines, the suitable warming YANG and invigorating QI of main strong treatment, and reinforcing body resistance, improves body function, so treatment main formula will embody this Chinese traditional treatment principle.A point card about the esophageal carcinoma is had nothing in common with each other, and establishment of the therapeutic methods and Applying Medicine is also thereupon different.But method for the treatment of total not from depressed liver-energy dispersing and QI regulating, sending down the abnormal ascending QI blood stasis dispelling, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the body resistance strengthening and constitution consolidating, promote the production of body fluid moisturize, heat-clearing and toxic substances removing, anticancer analgetic, warming YANG and invigorating QI etc.Publication number CN 102114116 A(application number 201010614022.9) Chinese patent literature disclose a kind of Chinese medicine for the treatment of esophageal carcinoma, be made up of Radix Cirsii Japonici 0.5-2 part, Radix Rhodiolae 0.5-2 part, Rhizoma Coptidis 0.5-2 part, tender Folium Pterocaryae 1-3 part and Japanese pagodatree leaf 1-3 part.Publication number CN 104107399 A(application number 201410396505.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of esophageal carcinoma, consist of Spica Prunellae 6-12 part, Radix Aconiti Kusnezoffii 6-12 part, Rhizoma Sparganii 6-12 part, Rhizoma Curcumae 3-6 part, Radix Glycyrrhizae 15-30 part, Cornu rhinocerotis 1.5-3 part, Radix Cirsii Japonici 4-7 weight portion.Publication number CN 102416083 A(application number 201110410618.1) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of esophageal carcinoma, comprising Radix Ginseng Rubra 3-6 part, Fructus Arctii 10-15 part, Rhizoma Pinelliae Preparatum 8-12 part, Scolopendra 4-8 part, Cortex Magnoliae Officinalis 8-12 part, Calculus Bovis 4-6 part, Radix Angelicae Sinensis 10-15 part, Fructus Forsythiae 15-20 part, Radix Salviae Miltiorrhizae 15-20 part.
Chinese traditional treatment is relative to Western medicine, pure natural obtains, have no side effect, safer, the traditional Chinese medical science is relatively more secure for the treatment of esophageal carcinoma, among the people also existing many formula about this disease for the treatment of, but the curative effect of most formula lacks the checking of clinical trial, is therefore necessary to work out a kind of stable curative effect reliably Chinese prescription.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of vanishing sputum and dispelling knot powder and the preparation of preparing simple, portable treatment esophageal carcinoma.
Technical scheme of the present invention is:
The vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, is prepared from primarily of following bulk drugs, is weight portion: Bombyx Batryticatus 10-20, Realgar 2-4, Scorpio 10-20, Oletum Trogopterori 10-20, Herba Catharanthi Rosei 4-6, Rhizoma Belamcandae 5-10, Fructus Bruceae 9-15, Indigo Naturalis 6-9, Air Bladder pseudosciaenae seu Acipenser 4-9, fresh Fel Canitis juice is appropriate.
In preferred scheme, Bombyx Batryticatus 13-17, Realgar 2.5-3.5, Scorpio 14-16, Oletum Trogopterori 14-16, Herba Catharanthi Rosei 4.5-5.5, Rhizoma Belamcandae 6-9, Fructus Bruceae 10-14, Indigo Naturalis 7-8, Air Bladder pseudosciaenae seu Acipenser 5-8, fresh Fel Canitis juice is appropriate.
Be more preferably, Bombyx Batryticatus 15, Realgar 3, Scorpio 15, Oletum Trogopterori 15, Herba Catharanthi Rosei 5, Rhizoma Belamcandae 7.5, Fructus Bruceae 12, Indigo Naturalis 7.5, Air Bladder pseudosciaenae seu Acipenser 6.5, fresh Fel Canitis juice is appropriate.
The preparation method of described powder is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis respectively water fly, dry, be ground into impalpable powder;
(3) get rice to be placed in pot and to heat, add Fructus Bruceae and Scorpio, little fire is fried, and frying to rice be yellowish-brown, and taking-up, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, sieve, be then placed in ethanol, flood at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverize and sieve together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
The preparation method of the vanishing sputum and dispelling knot powder of described treatment esophageal carcinoma, the amount of step (3) rice is 0.2 times of quality of medicinal material.
The preparation method of the vanishing sputum and dispelling knot powder of described treatment esophageal carcinoma, the order number that step (4) is sieved is that (preferred, the order number of sieve is 60-90 order to 50-100 order; Be more preferably, the order number of sieve is 80 orders).
The preparation method of the vanishing sputum and dispelling knot powder of described treatment esophageal carcinoma, the consumption of step (4) ethanol is 5 times of medical material weight.
The preparation method of the vanishing sputum and dispelling knot powder of described treatment esophageal carcinoma, step (4) dip time is that (preferred, dip time was 16-21 hour in 15-22 hour; Be more preferably, dip time is 18 hours).
The preparation method of the vanishing sputum and dispelling knot powder of described treatment esophageal carcinoma, step (5) was pulverized 80-140 order and (preferably, was pulverized 90-130 order; Be more preferably, pulverized 110 orders).
Present invention also offers the application of vanishing sputum and dispelling knot powder when preparing the medicine for the treatment of esophageal carcinoma of described treatment esophageal carcinoma.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Bombyx Batryticatus: base is former: for the larva of Bombycidae insecticide bombyx mori infects muscardine and ossified dry Scorpio.Nature and flavor: acrid in the mouth; Salty; Property is put down.Gui Jing: liver; Lung; Stomach warp.Function cures mainly: expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.Main frightened epilepsy is twitched; stroke facial paralysis; Migraine and general headache; Abscess of throat; Scrofula; Mumps; Rubella; Sore.
Realgar: base is former: be sulfide-based mineral Realgar race Realgar, main containing realgar (As
2s
2).Nature and flavor: pungent, temperature; Poisonous.Gui Jing: return liver, large intestine channel.Function cures mainly: removing toxic substances parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.For carbuncle furuncle, snake bite and insect sting, abdominal pain due to worm stagnation, infantile convulsion, malaria.
Scorpio: base is former: be the dry body of Buthidae animal Scorpio.Nature and flavor: pungent are flat; Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Oletum Trogopterori: base is former: be flying squirrel section animal trogopterus xanthipes or the dry feces flying the little flying squirrel of murine.Nature and flavor: sweet, temperature.Function cures mainly: promoting blood circulation to remove blood stasis, and parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.
Rhizoma Belamcandae: base is former: be the dry rhizome of irides Rhizoma Belamcandae.Nature and flavor: bitter, cold.Gui Jing: return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Fructus Bruceae: base is former: be the dry mature fruit of quassia Fructus Bruceae.Nature and flavor: bitter, cold; Slightly poisonous.Gui Jing: return large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving, corrosion wart.For dysentery, malaria; External treatment wart, clavus.
Indigo Naturalis: base is former: for the leaf of acanthaceous vegetable acanthaceous indigo, polygonaceae plant polygonum tinctorium ait. or cruciferae isatis or stem and leaf are through processing obtained dried powder or agglomerate.Nature and flavor: salty, cold.Gui Jing: return Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Air Bladder pseudosciaenae seu Acipenser: base is former: for Perciformes Sciaenidae Channa argus belongs to the Air Bladder pseudosciaenae seu Acipenser of animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet are flat.Gui Jing: enter kidney channel.Function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.
Fel Canitis: base is former: be the gallbladder of Canis animals Canis familiaris L..Nature and flavor: bitter in the mouth; Cold in nature.Gui Jing: liver; Liver Channel.Effect: liver heat removing and eyesight improving, hemostasis is invigorated blood circulation.For wind heat ophthalmalgia; Conjunctival congestion is puckery itches; Spit blood; Epistaxis; Ting ear; Skin infection scabies.Fresh Fel Canitis juice: base is former: after Canis familiaris L. is slaughtered, peeling is cut open the belly, and takes out gallbladder, beats juice.
The vanishing sputum and dispelling knot powder scientific formula for the treatment of esophageal carcinoma provided by the invention, preparation is simple, and taking convenience.In addition, excellent results of the present invention also shows:
1, selected materials is all Chinese medicine material, without any side effects;
2, this prescription meets Chinese medicine principle completely, has expectorant blood stasis dispelling, regulating the flow of QI to dissipate blood stasis relieves the pain, warming the spleen stomach invigorating effect;
3, clinical trial is evident in efficacy, can the activity of effective anticancer.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, be prepared from primarily of following bulk drugs: Bombyx Batryticatus 10g, Realgar 2g, Scorpio 10g, Oletum Trogopterori 10g, Herba Catharanthi Rosei 4g, Rhizoma Belamcandae 5g, Fructus Bruceae 9g, Indigo Naturalis 6g, Air Bladder pseudosciaenae seu Acipenser 4g, fresh Fel Canitis juice is appropriate.
The preparation method of the vanishing sputum and dispelling knot powder of above-mentioned treatment esophageal carcinoma is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) rice getting quality of medicinal material 0.2 times is placed in pot and heats, and adds Fructus Bruceae and Scorpio, and little fire is fried, and frying to rice is yellowish-brown, takes out, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, cross 50 mesh sieves, be then placed in the ethanol of medical material weight 5 times, flood 15 hours at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverized 80 mesh sieves together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
embodiment 2the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, be prepared from primarily of following bulk drugs: Bombyx Batryticatus 20g, Realgar 4g, Scorpio 20g, Oletum Trogopterori 20g, Herba Catharanthi Rosei 6g, Rhizoma Belamcandae 10g, Fructus Bruceae 15g, Indigo Naturalis 9g, Air Bladder pseudosciaenae seu Acipenser 9g, fresh Fel Canitis juice is appropriate.
The preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) rice getting quality of medicinal material 0.2 times is placed in pot and heats, and adds Fructus Bruceae and Scorpio, and little fire is fried, and frying to rice is yellowish-brown, takes out, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, cross 100 mesh sieves, be then placed in the ethanol of medical material weight 5 times, flood 22 hours at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverized 140 mesh sieves together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
Model case: xxx, man, 57 years old.Often dine out, diet is irregular, and dinner party is more usually, drink and add smoking, before three months, prominent sense chest pain, dysphagia, originally dry things is difficult to swallow, and saliva all can not be swallowed then, burn pain after breastbone, then arrive examination in hospital, be finally diagnosed as esophageal carcinoma in mid-term, carry out chemotherapy and radiation treatment, after stable disease takes a turn for the better, recuperation of going home, take medicine half a year, health is more weak, listless.
Take the vanishing sputum and dispelling knot powder powder of the present embodiment gained treatment esophageal carcinoma, taken three times a day, each 5-10 gram, 20 days courses for the treatment of.After taking one month, spirit takes a turn for the better, and the state of an illness takes a turn for the better to some extent, and continue to take after two months, patient mental is in good condition, and appetite is normal, and Hou Qu hospital check half a year, cancer cell number recovers normal value, without malaise symptoms.
embodiment 3the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, be prepared from primarily of following bulk drugs: Bombyx Batryticatus 13g, Realgar 2.5g, Scorpio 14g, Oletum Trogopterori 14g, Herba Catharanthi Rosei 4.5g, Rhizoma Belamcandae 6g, Fructus Bruceae 10g, Indigo Naturalis 7g, Air Bladder pseudosciaenae seu Acipenser 5g, fresh Fel Canitis juice is appropriate.
The preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) rice getting quality of medicinal material 0.2 times is placed in pot and heats, and adds Fructus Bruceae and Scorpio, and little fire is fried, and frying to rice is yellowish-brown, takes out, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, cross 60 mesh sieves, be then placed in the ethanol of medical material weight 5 times, flood 16 hours at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverized 90 mesh sieves together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
Model case: xxx, female, 53 years old.Before 3 months, feel pharyngalgia, have choking feeling, vexed swollen discomfort after breastbone, front pain, belch etc., the rear state of an illness constantly increases the weight of, appetite decline, figure is become thin, and is hard and dry, after can only eat liquid meal, to examination in hospital, x-ray shows, and tumor body is covered with whole esophagus, and size, as Semen phaseoli radiati, is diagnosed as esophageal carcinoma.
Take the vanishing sputum and dispelling knot powder of the present embodiment gained treatment esophageal carcinoma, taken three times a day, each 5-10 gram, 20 days courses for the treatment of.After taking one month, patient's symptom that feels uneasy takes a turn for the better to some extent, and rear continuation takes two courses for the treatment of, in good condition, and recover normal, check to hospital, tumor body loses, and nubbin is calcification, takes up organ no abnormality seen, follows up a case by regular visits to and do not recur so far.
embodiment 4the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, be prepared from primarily of following bulk drugs: Bombyx Batryticatus 17g, Realgar 3.5g, Scorpio 16g, Oletum Trogopterori 16g, Herba Catharanthi Rosei 5.5g, Rhizoma Belamcandae 9g, Fructus Bruceae 14g, Indigo Naturalis 8g, Air Bladder pseudosciaenae seu Acipenser 8g, fresh Fel Canitis juice is appropriate.
The preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) rice getting quality of medicinal material 0.2 times is placed in pot and heats, and adds Fructus Bruceae and Scorpio, and little fire is fried, and frying to rice is yellowish-brown, takes out, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, cross 90 mesh sieves, be then placed in the ethanol of medical material weight 5 times, flood 21 hours at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverized 130 mesh sieves together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
embodiment 5the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma, be prepared from primarily of following bulk drugs: Bombyx Batryticatus 15g, Realgar 3g, Scorpio 15g, Oletum Trogopterori 15g, Herba Catharanthi Rosei 5g, Rhizoma Belamcandae 7.5g, Fructus Bruceae 12g, Indigo Naturalis 7.5g, Air Bladder pseudosciaenae seu Acipenser 6.5g, fresh Fel Canitis juice is appropriate.
The preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) rice getting quality of medicinal material 0.2 times is placed in pot and heats, and adds Fructus Bruceae and Scorpio, and little fire is fried, and frying to rice is yellowish-brown, takes out, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, cross 80 mesh sieves, be then placed in the ethanol of medical material weight 5 times, flood 18 hours at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverized 110 mesh sieves together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
test example 1the clinical practice of the vanishing sputum and dispelling knot powder of embodiment 5 gained treatment esophageal carcinoma:
Subjects: filter out 384 routine esophageal cancer patients from tumour hospital's outpatient service, wherein women 168 example, male 216 example, oldest 70 years old, minimal ages 23 years old, 49.6 years old mean age, the course of disease five months-10 years, average course of disease 4.8 years, these patients are all early metaphase, advanced esophageal cancer by CT and check pathological section.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, takes every day twice (warm), each 5-10 gram (adjusting to some extent depending on concrete condition), 20 days courses for the treatment of, and matched group takes other medicine (WEIFUCHUN PIAN, XIAOAIPING PIAN, esophagus put down the conventional medication such as loose).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: esophageal carcinoma transference cure, electronic gastroscopy and check pathological section result are all normal, and body constitution recovers normal, observe half a year without recidivist; Effective: all or part of disappearance of clinical symptoms or electronic gastroscope show that cancerous protuberance has the change reduced, and digestive function recovers to some extent, and spirit is recovered to some extent, the state of an illness can be stablized; Invalid: before and after taking, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1 liang component group situation and patient treatment outcome
As shown in Table 1: through the treatment of 4 months, take the experimental group patient of embodiment 5 gained powder, early metaphase has 109 routine patients to cure, patients with terminal has 75 examples to be cured, and the state of an illness obtains stable patient and always has 89 examples, experimental group total effective rate 96.1%, it is 49 examples that matched group always cures number of cases, total effectively number of cases is 30 examples, and total effective rate is 79%, and its therapeutic effect is not as good as experimental group as seen.Illustrate thus, the present embodiment gained powder has significant curative effect to esophageal carcinoma.
The Bombyx Batryticatus that the present invention uses has dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat effect; Realgar has removing dampness and eliminating phlegm effect; Scorpio has dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain effect; Oletum Trogopterori has promoting blood circulation to remove blood stasis, anastalsis; Herba Catharanthi Rosei has detoxicating and fighting cancer, the effect of heat clearing away suppressing the hyperactive liver; Rhizoma Belamcandae has expectorant sore-throat relieving, antipyretic and antidote functions; Indigo Naturalis and Fructus Bruceae have heat-clearing and toxic substances removing, removing heat from blood effect; Fel Canitis has liver heat removing and eyesight improving, promoting blood circulation and hemostasis effect, multiple effective material, reasonably combined, synergism, to realize the effect of curing esophageal carcinoma.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the vanishing sputum and dispelling knot powder of esophageal carcinoma, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Bombyx Batryticatus 10-20, Realgar 2-4, Scorpio 10-20, Oletum Trogopterori 10-20, Herba Catharanthi Rosei 4-6, Rhizoma Belamcandae 5-10, Fructus Bruceae 9-15, Indigo Naturalis 6-9, Air Bladder pseudosciaenae seu Acipenser 4-9, fresh Fel Canitis juice is appropriate.
2. the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 1, is characterized in that, Bombyx Batryticatus 13-17, Realgar 2.5-3.5, Scorpio 14-16, Oletum Trogopterori 14-16, Herba Catharanthi Rosei 4.5-5.5, Rhizoma Belamcandae 6-9, Fructus Bruceae 10-14, Indigo Naturalis 7-8, Air Bladder pseudosciaenae seu Acipenser 5-8, fresh Fel Canitis juice is appropriate.
3. the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 1, it is characterized in that, Bombyx Batryticatus 15, Realgar 3, Scorpio 15, Oletum Trogopterori 15, Herba Catharanthi Rosei 5, Rhizoma Belamcandae 7.5, Fructus Bruceae 12, Indigo Naturalis 7.5, Air Bladder pseudosciaenae seu Acipenser 6.5, fresh Fel Canitis juice is appropriate.
4. the preparation method of the vanishing sputum and dispelling knot powder of the treatment esophageal carcinoma as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) get Air Bladder pseudosciaenae seu Acipenser to clean, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, be placed in cold-bottling, for subsequent use;
(2) get Realgar and Indigo Naturalis is ground into powder respectively, water flies, and dries, and is ground into impalpable powder;
(3) get rice to be placed in pot and to heat, add Fructus Bruceae and Scorpio, little fire is fried, and frying to rice be yellowish-brown, and taking-up, peels off the shell of Fructus Bruceae;
(4) by Herba Catharanthi Rosei and step (3) institute rice milling Fructus Bruceae, pulverize together, sieve, be then placed in ethanol, flood at constant temperature 50 DEG C, constantly stir while dipping, filter, concentrated, dry;
(5) will remain medical material decontamination, dry, pulverize and sieve together with the made medical material of above-mentioned steps, and mix with the fresh Fel Canitis juice of total medicated powder quality 0.2 times, lyophilization, pulverize, sterilizing, subpackage, obtains powder.
5. the preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 4, it is characterized in that, the amount of step (3) rice is 0.2 times of quality of medicinal material.
6. the preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 4, is characterized in that, the order number that step (4) is sieved is that (preferred, the order number of sieve is 60-90 order to 50-100 order; Be more preferably, the order number of sieve is 80 orders).
7. the preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 4, it is characterized in that, the consumption of step (4) ethanol is 5 times of medical material weight.
8. the preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 4, is characterized in that, step (4) dip time is that (preferred, dip time was 16-21 hour in 15-22 hour; Be more preferably, dip time is 18 hours).
9. the preparation method of the vanishing sputum and dispelling knot powder for the treatment of esophageal carcinoma as claimed in claim 4, it is characterized in that, step (5) was pulverized 80-140 order and (preferably, was pulverized 90-130 order; Be more preferably, pulverized 110 orders).
10. the application of vanishing sputum and dispelling knot powder when preparing the medicine for the treatment of esophageal carcinoma of the treatment esophageal carcinoma as described in as arbitrary in claim 1-3.
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Citations (2)
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| CN1270040A (en) * | 2000-03-13 | 2000-10-18 | 徐忠廷 | Anti-cancer Chinese-medicinal pill |
| CN103977256A (en) * | 2014-05-23 | 2014-08-13 | 李绍华 | Medicine composition for treating cancer |
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2014
- 2014-12-13 CN CN201410760918.6A patent/CN104383148A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270040A (en) * | 2000-03-13 | 2000-10-18 | 徐忠廷 | Anti-cancer Chinese-medicinal pill |
| CN103977256A (en) * | 2014-05-23 | 2014-08-13 | 李绍华 | Medicine composition for treating cancer |
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| 王文萍: "《肿瘤的中医诊疗》", 31 July 2007, 中国中医药出版社 * |
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Address after: The 830000 Xinjiang Midong District of Urumqi Miquan Road No. 790 Building No. 3 1-402 Applicant after: Li Fei Address before: 250014 Shandong city in Ji'nan Province, Lixia District, Dongguan Street No. 38 Applicant before: Li Fei |
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Application publication date: 20150304 |