CN103301385B - Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating animal diarrhea and a preparation method thereof, and belongs to the field of traditional Chinese medicine for treating animal diarrhea. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of roxburgh rose root, 10-30 parts of desmodium triquetrum, 20-40 parts of Brucea javanica, 8-25 parts of myrobalan, 6-15 parts of Schisandra chinensis, 6-15 parts of honeysuckle and 4-10 parts of Amomum tsao-ko. The traditional Chinese medicine composition disclosed by the invention has the functions of clearing away heat and toxic materials and astringing to arrest diarrhea and antisepsis and anti-inflammation function. Clinical curative effect observation verifies that the traditional Chinese medicine composition disclosed by the invention has remarkable curative effect on diarrhea of animal such as cattle, sheep, hogs and livestock, and is quick in effect, exact, reliable and true in curative effect. The traditional Chinese medicine composition disclosed by the invention is non-toxic and harmless to animals and safe and reliable. No adverse reactions of animals are found in clinical using process, so that the traditional Chinese medicine composition is clinically safe to use.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of animal diarrhea, particularly relate to and a kind ofly relate to Chinese medicine composition for the treatment of animal diarrhea and preparation method thereof, belong to the treatment by Chinese herbs field of animal diarrhea.
Background technology
Animal diarrhea is the commonly encountered diseases of a kind of long-standing problem raiser, frequently-occurring disease and epidemic diseases, and ill livestock and poultry mortality rate is high, causes very large economic loss to raiser.Cause the reason of animal diarrhea a lot, the cause of disease of infectious diarrhea relates to virus, antibacterial, parasite etc., and the leak etc. in temperature, humidity, nutrition and feeding process is also the inducement that the non-infectious property diarrhoea of animal occurs.In addition, the toleration of animal itself, anti-adversity, self-regeneration function, the basic physiological structure of animal and the life habit of animal also easily suffer from animal suffer from diarrhoea relevant.
In production practices; normal use antiviral and antibacterials, supplement body fluid etc. way treat animal diarrhea; usually have ignored the primary demand of animal; also the basic inducement and route of transmission that cause these problems is ignored; there is a lot of problems over the course for the treatment of; such as: the resistance of animal own declines, and easily brings out other mixed infections; The speed of growth is slow, and intestinal regulating liver-QI kidney injury is too serious, and intestinal thalline is unbalance, and intestinal villi damage is serious; In body, harmful substance accumulates in a large number, impaired organ, animal physiological dysfunction.What usually show is exactly that therapeutic effect is not good, and recover slowly after being ill, pathogenic microorganism Drug resistance increases, and aggravation is even dead.
Chinese patent medicine has certain curative effect for the diarrhoea of animal, and slow, the defect such as curative effect is remarkable not but the existing Chinese patent medicine being used for the treatment of animal diarrhea also existing all is in various degree taken effect, haves much room for improvement.
Summary of the invention
The present invention's technical problem first to be solved is slow, the inapparent defect of curative effect that takes effect existing for Chinese medicine composition overcoming existing treatment animal diarrhea, provides the Chinese medicine composition of the treatment animal diarrhea of a kind of instant effect, determined curative effect.
Another technical problem to be solved by this invention is to provide a kind of method preparing the Chinese medicine composition of described treatment animal diarrhea.
Technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for animal diarrhea, comprise each component of following weight portion:
Fructus Bruceae 20-40 part, Radix Rosae Normalis 10-30 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-30 part, Fructus Chebulae 8-25 part, Fructus Schisandrae Chinensis 6-15 part, Flos Lonicerae 6-15 part, Fructus Tsaoko 4-10 part.
Preferably, the weight portion of each component is: Fructus Bruceae 20-35 part, Radix Rosae Normalis 10-20 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part, Fructus Chebulae 8-15 part, Fructus Schisandrae Chinensis 6-10 part, Flos Lonicerae 6-10 part, Fructus Tsaoko 4-8 part.
Preferred, the weight portion of each component is: Fructus Bruceae 25 parts, Radix Rosae Normalis 15 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 parts, Fructus Chebulae 10 parts, Fructus Schisandrae Chinensis 8 parts, Flos Lonicerae 8 parts, Fructus Tsaoko 6 parts.
Chinese medicine composition of the present invention is to the research of the deep layer pathogenesis of animal diarrhea and Therapeutic Principle thereof based on inventor, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug of heat-clearing and toxic substances removing, astringing to arrest diarrhea, anti-inflammation, form according to certain weight proportion prescription.
Radix Rosae Normalis: different name thatch Herba chenopodii daughter root, thatch Herba chenopodii root.For the root of rosaceous plant Fructus Rosae Normalis Rosa roxburghiiTratt.f.normalis Rehd.et Wils..Gather between 7 ~ August.Root, stem are all containing tannin.The root bark that is produced from Sichuan is containing tannin.Again containing vitamin B-2 .4%, Citrin-2.8%.Nature and flavor: sweet acid are flat.Function cures mainly: stomach invigorating, helps digestion, antidiarrheal, arresting seminal emission.Treat for stomachache, have loose bowels, dysentery, seminal emission, metrorrhagia, leukorrhagia, chronic cough.
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): leguminous plant Herba Desmodii Triquetri (Herba Tadehagi Triquetri) Desmodium triquetrum(L.) herb of DC..Xia Qiu gathers, and cleans and chops up, dry.Using fresh herb can be adopted at any time.Nature and flavor: pained, cool.Function cures mainly: heat-clearing and toxic substances removing, removing food stagnancy dampness removing, and disappear stagnant, parasite killing is anticorrosion.Cure cold heating, laryngopharynx swelling and pain, pneumonopathy hemoptysis, enteritis, dysentery, jaundice, rheumatic arthritis, ancylostomiasis, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, infantile malnutrition, skin ulcer scabies.
Fructus Bruceae: another name crow gallbladder, of refined dawn etc.For the fruit of quassia Fructus Bruceae Brucea javanica (L.) Merr..Gather during fruit maturation in autumn, Ex-all branch and leaf impurity, cleans, dries.Used time peels off shell, rounds the raw use of core.Nature and flavor: bitter, cold, slightly poisonous.Function cures mainly: heat clearing away, dampness, parasite killing, removing toxic substances.Control dysentery, chronic diarrhea, malaria, hemorrhoid, furunculosis, wart, clavus.
Fructus Chebulae: another name chebule, scold multitude, with the wind son.For the fruit of Combretum Racemosum plant Fructus Chebulae Terminaliachebula Retz..Pluck during fruit maturation at the beginning of winter in autumn, dry.Nature and flavor: picric acid is puckery, temperature.Return lung meridian, stomach warp, large intestine channel.Function cures mainly: astringe the lung, astringing intestine to stop diarrhea, the therapeutic method to keep the adverse QI flowing downwards.Control chronic cough aphonia, chronic diarrhea, chronic dysentery, proctoptosis, have blood in stool, metrorrhagia, leukorrhagia, seminal emission, frequent micturition.
Fructus Schisandrae Chinensis: be the fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Nature and flavor: acid, temperature.Return lung meridian, kidney channel.Function cures mainly: astringe the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Flos Lonicerae: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Fructus Tsaoko: another name Fructus Tsaoko, SEMEN TSAOKO.For the fruit of zingiberaceous plant Fructus Tsaoko Amomum tsao-koCrevostet Lem..Nature and flavor: acrid in the mouth, warm in nature, nontoxic.Return spleen channel, stomach warp.Function cures mainly: dampness is except cold, and eliminate the phlegm preventing the attack (or recurrence) of malaria, and help digestion relieving dyspepsia.Treating malaria disease, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.
For animal diarrhea, there is better therapeutic efficiency when adding the raw material of following weight portion in the present invention in drug composition further: Herba polygoni hydropiperis 8-25 part, Herba Andrographis 3-8 part, Folium Isatidis 3-8 part, Cortex Querci Mongolicae 4-10 part; Preferably, the consumption of each component is: Herba polygoni hydropiperis 10 parts, Herba Andrographis 4 parts, Folium Isatidis 4 parts, Cortex Querci Mongolicae 6 parts.
Herba Andrographis: be acanthaceous plant Herba Andrographis (Andrographis paniculata(Burm.f.) Nees) herb or leaf.Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Nature and flavor: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pneumonia, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, burn due to hot liquid or fire, furuncle carbuncle, venom.
Folium Isatidis: be leaf or the branch and leaf of Verbenaceae Herba Diclipterae Chinensis, few section plant polygonum tinctorium ait., cruciferae isatis, careless Folium Isatidis or acanthaceous vegetable acanthaceous indigo etc.Nature and flavor: bitter, cold.Return Liver Channel, heart channel, stomach warp.Function cures mainly: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Cortex Querci Mongolicae: be the bark of Fagaceae Mongolian oak (Quercus mongolica Fisch.).Spring, autumn adopt, and scrape off outer rough bark, dry or cineration.Mildly bitter flavor, puckery; Property is put down.Function cures mainly: dampness removing, heat clearing away, removing toxic substances.Control enteritis, diarrhea, dysentery, jaundice, hemorrhoid.
Herba polygoni hydropiperis: the dry herb of polygonaceae plant Folium Salicis Babylonicae knotweed Polygonum lapathifolium L.var.salicifoliumSibth..Summer, season in autumn two gather, removing impurity, cleaning, drying.Property pungent, temperature.Return lung, liver, large intestine channel.Function cures mainly: reducing swelling and alleviating pain.Control swollen intestinal, dysentery is suffered from abdominal pain.
Animal described in the present invention is preferably cattle, sheep, pig or poultry; Described poultry is preferably chicken, duck or goose.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
Various adjuvants required when medicine activity component of the present invention can add the dosage form preparing oral formulations are prepared into the method for Chinese medicinal of routine the oral formulations that any one is suitable for animal clinically, such as, can be powder, granule or oral liquid etc.
Thus, the invention provides a kind of method preparing described Chinese medicine composition, comprising:
(1) each component is taken by described weight portion;
(2) by each component mix homogeneously, pulverize, sieve (can be such as 60-800 mesh sieve, be preferably 80-200 order), to obtain final product.
The another kind of preparation method of Chinese medicine composition of the present invention:
(1) each component is taken by described weight portion;
(2) component is pulverized and sieved rear soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, to obtain final product.
The rear 3-8 times of weight water that wherein each component pulverized and sieved in step (2) decocts 2-4 time, each decoction 1.5 hours.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as diarrhoea degree and kind of concrete dosage form, animal.As guidance: for powder, powder boiled water of getting it filled gavages after soaking, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiments are only exemplary, do not form any restriction to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 powder
(1) by described weight take each component (unit: g): Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Bruceae 25, Fructus Chebulae 10, Fructus Tsaoko 6, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8;
(2) by each component mix homogeneously, pulverize, cross 100 mesh sieves, to obtain final product.
The preparation of embodiment 2 powder
(1) by described weight take each component (unit: g): Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Bruceae 20, Fructus Chebulae 8, Fructus Tsaoko 4, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6;
(2) by each component mix homogeneously, pulverize, cross 80 mesh sieves, to obtain final product.
The preparation of embodiment 3 powder
(1) by described weight take each component (unit: g): Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Bruceae 40, Fructus Chebulae 25, Fructus Tsaoko 10, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15;
(2) by each component mix homogeneously, pulverize, cross 120 mesh sieves, to obtain final product.
The preparation of embodiment 4 powder
(1) by described weight take each component (unit: g): Fructus Bruceae 20, Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Chebulae 8, Herba polygoni hydropiperis 8, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6, Cortex Querci Mongolicae 4, Fructus Tsaoko 4, Herba Andrographis 3, Folium Isatidis 3;
(2) by each component mix homogeneously, pulverize, cross 120 mesh sieves, to obtain final product.
The preparation of embodiment 5 powder
(1) by described weight take each component (unit: g): Fructus Bruceae 40, Radix Rosae Normalis 10-30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Chebulae 25, Herba polygoni hydropiperis 25, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15, Cortex Querci Mongolicae 10, Fructus Tsaoko 10, Herba Andrographis 8, Folium Isatidis 8;
(2) by each component mix homogeneously, pulverize, cross 80 mesh sieves, to obtain final product.
The preparation of embodiment 6 powder
(1) by described weight take each component (unit: g): Fructus Bruceae 25, Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Chebulae 10, Herba polygoni hydropiperis 10, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8, Cortex Querci Mongolicae 6, Fructus Tsaoko 6, Herba Andrographis 4, Folium Isatidis 4;
(2) by each component mix homogeneously, pulverize, cross 120 mesh sieves, to obtain final product.
The preparation of embodiment 7 granule
(1) by described weight take each component (unit: g): Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Bruceae 25, Fructus Chebulae 10, Fructus Tsaoko 6, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8;
(2) by each component mix homogeneously, with the soak by water 3 times of 6 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The preparation of embodiment 8 granule
(1) by described weight take each component (unit: g): Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Bruceae 20, Fructus Chebulae 8, Fructus Tsaoko 4, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6;
(2) by each component mix homogeneously, with the soak by water 2 times of 8 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The preparation of embodiment 9 granule
(1) by described weight take each component (unit: g): Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Bruceae 40, Fructus Chebulae 25, Fructus Tsaoko 10, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15;
(2) by each component mix homogeneously, with the soak by water 3 times of 5 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The preparation of embodiment 10 granule
(1) by described weight take each component (unit: g): Fructus Bruceae 20, Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Chebulae 8, Herba polygoni hydropiperis 8, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6, Cortex Querci Mongolicae 4, Fructus Tsaoko 4, Herba Andrographis 3, Folium Isatidis 3;
(2) by each component mix homogeneously, with the soak by water 3 times of 5 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The preparation of embodiment 11 granule
(1) by described weight take each component (unit: g): Fructus Bruceae 40, Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Chebulae 25, Herba polygoni hydropiperis 25, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15, Cortex Querci Mongolicae 10, Fructus Tsaoko 10, Herba Andrographis 8, Folium Isatidis 8;
(2) by each component mix homogeneously, with the soak by water 3 times of 5 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The preparation of embodiment 12 granule
(1) by described weight take each component (unit: g): Fructus Bruceae 25, Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Chebulae 10, Herba polygoni hydropiperis 10, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8, Cortex Querci Mongolicae 6, Fructus Tsaoko 6, Herba Andrographis 4, Folium Isatidis 4;
(2) by each component mix homogeneously, with the soak by water 3 times of 5 times of weight, decoction liquor filtered, filtrate is condensed into thick paste, obtains dried cream powder by after thick paste spraying dry, adds the adjuvant of preparations shaping, makes granule, to obtain final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating animal diarrhea of the present invention
One, physical data: accepted the pig that 160 examples suffer from diarrhoea for medical treatment.Accepted for medical treatment 160 routine pigs all in various degree show lassitude, loss of appetite, body temperature changes, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meets clinical animal diarrhea diagnostic criteria.160 routine pigs are divided into two groups at random, often organize each 80 examples.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-12.
Three, Therapeutic Method
The pig suffering from diarrhoea by 160 is divided into 2 groups at random, that is: test 1 group and test 2 groups, often organizes each 80 examples.Test the Drug therapy of 1 group of employing prepared by embodiment 1-3, test the Drug therapy of 2 groups of employings prepared by embodiment 4-6.Treatments period stop using other related drugs and other treatment.
Powder: powder boiled water of getting it filled gavages after soaking, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get after granule boiled water soaks and gavage, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, symptom of diarrhea disappears completely, and function recovers normal completely.
Remarkable: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and function recovers normal substantially.
Effective: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result is in table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating diarrhea of pigs of the present invention
With the 2-3 days of traditional Chinese medicine composition for treating pig of the present invention, great majority all have obviously alleviate by the symptoms for the treatment of diarrhea of pigs; Treat 3-4 days, the symptom by treatment diarrhea of pigs is significantly improved; By the 5th day for the treatment of, the symptom of diarrhea of pigs disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect result shows, evident in efficacy for diarrhea of pigs of Chinese medicine composition of the present invention; In whole therapeutic process, do not observe the animal be treated occur any untoward reaction, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 2 traditional Chinese medicine composition for treating chicken diarrhea of the present invention
One, physical data: accepted the chicken that 196 examples suffer from diarrhoea for medical treatment.Accepted for medical treatment 196 routine chickens all in various degree show lassitude, loss of appetite, body temperature changes, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meets clinical animal diarrhea diagnostic criteria.196 chickens are divided into two groups at random, often organize each 98 examples.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-12.
Three, Therapeutic Method
Often kind of animal is divided into 2 groups at random, that is: tests 1 group and test 2 groups, often organize each 98 examples of chicken.Test 1 group adopt embodiment 1-3(or embodiment 7-9) prepared by Drug therapy, test 2 groups adopt embodiment 4-6(or embodiment 10-12) prepared by Drug therapy.Treatments period stop using other related drugs and other treatment.
Powder: powder boiled water of getting it filled gavages after soaking, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get after granule boiled water soaks and gavage, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, symptom of diarrhea disappears completely, and function recovers normal completely.
Remarkable: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and function recovers normal substantially.
Effective: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result is in table 2.
The clinical observation on the therapeutic effect result of the test of table 2 traditional Chinese medicine composition for treating chicken diarrhea of the present invention
With the 2nd day of traditional Chinese medicine composition for treating animal of the present invention, great majority all had obviously alleviate by the symptoms for the treatment of chicken diarrhea; Treat 3-4 days, the symptom by treatment chicken diarrhea is significantly improved; By the 5th day for the treatment of, the symptom of chicken diarrhea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect result shows, evident in efficacy for chicken diarrhea of Chinese medicine composition of the present invention; In whole therapeutic process, do not observe the animal be treated occur any untoward reaction, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 3 traditional Chinese medicine composition for treating animal diarrhea of the present invention
One, physical data: accepted the cattle that 120 examples suffer from diarrhoea for medical treatment.Accepted for medical treatment 120 routine cattle all in various degree show lassitude, loss of appetite, body temperature changes, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meets clinical animal diarrhea diagnostic criteria.The Niu Suiji 120 examples being suffered from diarrhoea is divided into two groups, often organizes each 60 examples.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-12.
Three, Therapeutic Method
Often kind of animal is divided into 2 groups at random, that is: tests 1 group and test 2 groups, often organize each 60 examples of cattle.Test 1 group adopt embodiment 1-3(or embodiment 7-9) prepared by Drug therapy, test 2 groups adopt embodiment 4-6(or embodiment 10-12) prepared by Drug therapy.Treatments period stop using other related drugs and other treatment.
Powder: powder boiled water of getting it filled gavages after soaking, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get after granule boiled water soaks and gavage, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, symptom of diarrhea disappears completely, and function recovers normal completely.
Remarkable: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and function recovers normal substantially.
Effective: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result is in table 3.
The clinical observation on the therapeutic effect result of the test of table 3 traditional Chinese medicine composition for treating cattle diarrhoea of the present invention
With the 2nd day of traditional Chinese medicine composition for treating cattle of the present invention, great majority all had obviously alleviate by the symptoms for the treatment of cattle diarrhoea; Treat the 3rd day, the symptom by treatment cattle diarrhoea is significantly improved; By the 5th day for the treatment of, the symptom of cattle diarrhoea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention for cattle suffer from diarrhoea evident in efficacy; In whole therapeutic process, do not observe the animal cattle be treated occur any untoward reaction, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 4 traditional Chinese medicine composition for treating sheep diarrhea of the present invention
One, physical data: accepted the sheep that 120 examples suffer from diarrhoea for medical treatment.Accepted for medical treatment 120 routine sheep all in various degree show lassitude, loss of appetite, body temperature changes, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meets clinical animal diarrhea diagnostic criteria.120 routine sheep are divided into 2 groups at random, often organize each 60 examples.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-12.
Three, Therapeutic Method
Often kind of animal is divided into 2 groups at random, that is: tests 1 group and test 2 groups, often organize each 60 examples of sheep.Test 1 group adopt embodiment 1-3(or embodiment 7-9) prepared by Drug therapy, test 2 groups adopt embodiment 4-6(or embodiment 10-12) prepared by Drug therapy.Treatments period stop using other related drugs and other treatment.
Powder: powder boiled water of getting it filled gavages after soaking, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get after granule boiled water soaks and gavage, 0.5g medicated powder corresponding 1kg infected animal body weight; Every day 2 times 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, symptom of diarrhea disappears completely, and function recovers normal completely.
Remarkable: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and function recovers normal substantially.
Effective: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result is in table 4.
The clinical observation on the therapeutic effect result of the test of table 4 traditional Chinese medicine composition for treating sheep diarrhea of the present invention
Suffer from diarrhoea the 2nd day of sheep by traditional Chinese medicine composition for treating of the present invention, great majority all have by the symptom for the treatment of sheep diarrhea and obviously alleviate; Treat the 3rd day, the symptom by treatment sheep diarrhea is significantly improved; By the 5th day for the treatment of, the symptom of sheep diarrhea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect result shows, evident in efficacy for sheep diarrhea of Chinese medicine composition of the present invention; In whole therapeutic process, do not observe the sheep be treated occur any untoward reaction, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (6)
1. treat the Chinese medicine composition of animal diarrhea for one kind, be made up of each crude drug of following weight portion: Radix Rosae Normalis 10-30 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-30 part, Herba Andrographis 3-8 part, Folium Isatidis 3-8 part, Fructus Bruceae 20-40 part, Fructus Chebulae 8-25 part, Herba polygoni hydropiperis 8-25 part, Fructus Schisandrae Chinensis 6-15 part, Flos Lonicerae 6-15 part, Cortex Querci Mongolicae 4-10 part and Fructus Tsaoko 4-10 part; Described animal is cattle, sheep, pig or poultry; Described poultry is chicken, duck or goose.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Radix Rosae Normalis 15 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 parts, Herba Andrographis 4 parts, Folium Isatidis 4 parts, Fructus Bruceae 25 parts, Fructus Chebulae 10 parts, Herba polygoni hydropiperis 10 parts, Fructus Schisandrae Chinensis 8 parts, Flos Lonicerae 8 parts, Cortex Querci Mongolicae 6 parts, Fructus Tsaoko 6 parts.
3. according to the Chinese medicine composition described in claim 1 or 2, it is characterized in that: be prepared into powder, granule or oral liquid.
4. prepare a method for Chinese medicine composition described in claim 1 or 2, comprise the following steps:
(1) each crude drug is taken by described weight portion;
(2) each crude drug is pulverized, sieve, to obtain final product.
5. prepare a method for Chinese medicine composition described in claim 1 or 2, comprise the following steps:
(1) each crude drug is taken by described weight portion;
(2) crude drug is pulverized and sieved rear soak by water, decoction liquor is filtered, and filtrate is condensed into clear paste, adds the adjuvant of preparations shaping, to obtain final product.
6. the purposes of Chinese medicine composition described in claim 1 or 2 in preparation treatment animal diarrhea medicine; Described animal is cattle, sheep, pig or poultry; Described poultry is chicken, duck or goose.
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| CN102641445A (en) * | 2012-04-08 | 2012-08-22 | 张红 | Medicine for treating dysentery and preparing method thereof |
| CN103041048A (en) * | 2012-12-21 | 2013-04-17 | 姜凤丽 | Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same |
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| CN102641445A (en) * | 2012-04-08 | 2012-08-22 | 张红 | Medicine for treating dysentery and preparing method thereof |
| CN103041048A (en) * | 2012-12-21 | 2013-04-17 | 姜凤丽 | Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same |
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