CN103301385A - Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof Download PDFInfo
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- CN103301385A CN103301385A CN2013101959745A CN201310195974A CN103301385A CN 103301385 A CN103301385 A CN 103301385A CN 2013101959745 A CN2013101959745 A CN 2013101959745A CN 201310195974 A CN201310195974 A CN 201310195974A CN 103301385 A CN103301385 A CN 103301385A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating animal diarrhea and a preparation method thereof, and belongs to the field of traditional Chinese medicine for treating animal diarrhea. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of roxburgh rose root, 10-30 parts of desmodium triquetrum, 20-40 parts of Brucea javanica, 8-25 parts of myrobalan, 6-15 parts of Schisandra chinensis, 6-15 parts of honeysuckle and 4-10 parts of Amomum tsao-ko. The traditional Chinese medicine composition disclosed by the invention has the functions of clearing away heat and toxic materials and astringing to arrest diarrhea and antisepsis and anti-inflammation function. Clinical curative effect observation verifies that the traditional Chinese medicine composition disclosed by the invention has remarkable curative effect on diarrhea of animal such as cattle, sheep, hogs and livestock, and is quick in effect, exact, reliable and true in curative effect. The traditional Chinese medicine composition disclosed by the invention is non-toxic and harmless to animals and safe and reliable. No adverse reactions of animals are found in clinical using process, so that the traditional Chinese medicine composition is clinically safe to use.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of animal diarrhoea, relate in particular to a kind of Chinese medicine composition for the treatment of animal diarrhoea and preparation method thereof that relates to, belong to the treatment by Chinese herbs field of animal diarrhoea.
Background technology
Animal diarrhoea is a kind of long-term puzzlement raiser's commonly encountered diseases, frequently-occurring disease and epidemic diseases, and ill livestock and poultry mortality rate is high, causes very large economic loss to the raiser.Cause the reason of animal diarrhoea a lot, the cause of disease of infectious diarrhea relates to virus, antibacterial, parasite etc., and the leak in temperature, humidity, nutrition and the feeding process etc. also is the inducement that the non-infectious property of animal diarrhoea occurs.In addition, the life habit of the basic physiological structure of the toleration of animal itself, anti-adversity, self-regeneration function, animal and animal also with animal easily suffer from diarrhoea relevant.
In production practices, normal with antiviral and antibacterials, replenish body fluid etc. way treat animal and suffer from diarrhoea, the primary demand of usually having ignored animal, the basic inducement and the route of transmission that cause these problems have also been ignored, a lot of problems has appearred in therapeutic process, for example: the resistance of animal own descends, and easily brings out other mixed infections; The speed of growth is slow, and intestinal regulating liver-QI kidney injury is too serious, and the intestinal thalline is unbalance, and the intestinal villi damage is serious; Harmful substance accumulates in a large number in the body, and organ is impaired, animal physiological dysfunction.Usually performance is exactly that therapeutic effect is not good, recovers after being ill slowly, and the pathogenic microorganism Drug resistance increases, aggravation even death etc.
Chinese patent medicine has certain curative effect for the diarrhoea of animal, but the existing Chinese patent medicine that is used for the treatment of animal diarrhoea all in various degree exist slow, the defective such as curative effect is remarkable not that takes effect, have much room for improvement.
Summary of the invention
The present invention's technical problem at first to be solved is Chinese medicine composition existing take effect slow, the inapparent defective of curative effect that overcomes existing treatment animal diarrhoea, and the Chinese medicine composition of the treatment animal diarrhoea of a kind of instant effect, determined curative effect is provided.
Another technical problem to be solved by this invention provides a kind of method for preparing the Chinese medicine composition of described treatment animal diarrhoea.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of animal diarrhoea comprises each component of following weight portion:
Fructus Bruceae 20-40 part, Radix Rosae Normalis 10-30 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-30 part, Fructus Chebulae 8-25 part, Fructus Schisandrae Chinensis 6-15 part, Flos Lonicerae 6-15 part, Fructus Tsaoko 4-10 part.
Preferably, the weight portion of each component is: Fructus Bruceae 20-35 part, Radix Rosae Normalis 10-20 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part, Fructus Chebulae 8-15 part, Fructus Schisandrae Chinensis 6-10 part, Flos Lonicerae 6-10 part, Fructus Tsaoko 4-8 part.
Preferred, the weight portion of each component is: 25 parts of Fructus Bruceaes, 15 parts of Radix Rosae Normaliss, 15 parts of Herba Desmodii Triquetri (Herba Tadehagi Triquetri)s, 10 parts of Fructus Chebulaes, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Flos Loniceraes, 6 parts of Fructus Tsaokos.
Chinese medicine composition of the present invention is based on the inventor to research and the Therapeutic Principle thereof of the deep layer pathogenesis of animal diarrhoea, simultaneously according to inventor for many years clinical experience and pharmaceutical research achievement, filter out the crude drug of heat-clearing and toxic substances removing, astringing to arrest diarrhea, anti-inflammation, form according to certain weight proportion prescription.
Radix Rosae Normalis: different name thatch Herba chenopodii daughter root, thatch Herba chenopodii root.Root for rosaceous plant Fructus Rosae Normalis Rosa roxburghii Tratt.f.normalis Rehd.et Wils..Gather between 7～August.Root, stem all contain tannin.The root bark that produce in Sichuan contains tannin.Contain again vitamin B-2 .4%, Citrin-2.8%.Nature and flavor: sweet acid, flat.Function cures mainly: stomach invigorating helps digestion antidiarrheal, arresting seminal emission.Treat for stomachache, have loose bowels, dysentery, seminal emission, metrorrhagia, leukorrhagia, chronic cough.
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): the leguminous plant Herba Desmodii Triquetri (Herba Tadehagi Triquetri) Desmodium triquetrum(L.) herb of DC..Xia Qiu gathers, and cleans to chop up, and dries.Using fresh herb can be adopted at any time.Nature and flavor: bitterness, cold.Function cures mainly: heat-clearing and toxic substances removing, and the removing food stagnancy dampness removing disappears stagnant, and parasite killing is anticorrosion.The heating that cures cold, laryngopharynx swelling and pain, pneumonopathy hemoptysis, enteritis, dysentery, jaundice, rheumatic arthritis, ancylostomiasis, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, infantile malnutrition, skin ulcer scabies.
Fructus Bruceae: another name crow gallbladder, refined dawn etc.Fruit for quassia Fructus Bruceae Brucea javanica (L.) Merr..Gather during fruit maturation autumn, and Ex-all branch and leaf impurity is cleaned, and dries.Time spent is peelled off shell, rounds core and gives birth to usefulness.Nature and flavor: hardship, cold, slightly poisonous.Function cures mainly: heat clearing away, dampness, parasite killing, detoxifcation.Control dysentery, chronic diarrhea, malaria, hemorrhoid, furunculosis, wart, clavus.
The Fructus Chebulae: the another name chebule, scold multitude, with the wind the son.Fruit for Combretum Racemosum plant Fructus Chebulae Terminalia chebula Retz..Pluck during fruit maturation at the beginning of winter in autumn, dry.Nature and flavor: picric acid is puckery, temperature.Return lung meridian, stomach warp, large intestine channel.Function cures mainly: astringe the lung astringing intestine to stop diarrhea, the therapeutic method to keep the adverse QI flowing downwards.Control chronic cough aphonia, chronic diarrhea, chronic dysentery, proctoptosis is had blood in stool, metrorrhagia, leukorrhagia, seminal emission, frequent micturition.
Fructus Schisandrae Chinensis: be the fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Nature and flavor: acid, temperature.Return lung meridian, kidney channel.Function cures mainly: astringe the lung, nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Flos Lonicerae: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function cures mainly: heat clearing away, detoxifcation.Control the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Fructus Tsaoko: another name Fructus Tsaoko, SEMEN TSAOKO.Fruit for zingiberaceous plant Fructus Tsaoko Amomum tsao-koCrevost et Lem..Nature and flavor: acrid in the mouth, warm in nature, nontoxic.Return spleen channel, stomach warp.Function cures mainly: dampness is removed cold, the preventing the attack (or recurrence) of malaria that eliminates the phlegm, and relieving dyspepsia helps digestion.The treating malaria disease, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.
Suffer from diarrhoea for animal when further adding in the present invention the raw material of following weight portion in the drug composition and have better therapeutic efficiency: Herba polygoni hydropiperis 8-25 part, Herba Andrographis 3-8 part, Folium Isatidis 3-8 part, Cortex Querci Mongolicae 4-10 part; Preferably, the consumption of each component is: 10 parts of Herba polygoni hydropiperiss, 4 parts of Herba Andrographis, 4 parts of Folium Isatidiss, 6 parts of Cortex Querci Mongolicaes.
Herba Andrographis: be acanthaceous plant Herba Andrographis (Andrographis paniculata(Burm.f.) Nees) herb or leaf.Have another name called Chun Lianqiuliu, Herba Andrographitis, olive nuclear lotus, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Nature and flavor: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood detumescence.Control acute dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pneumonia, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, burn due to hot liquid or fire, furuncle carbuncle, venom.
Folium Isatidis: be leaf or the branch and leaf of Verbenaceae Herba Diclipterae Chinensis, few section plant polygonum tinctorium ait., cruciferae isatis, careless Folium Isatidis or acanthaceous vegetable acanthaceous indigo etc.Nature and flavor: hardship, cold.Return Liver Channel, heart channel, stomach warp.Function cures mainly: heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Cortex Querci Mongolicae: be the bark of Fagaceae Mongolian oak (Quercus mongolica Fisch.).Spring, autumn adopt, and scrape off outer rough bark, dry or cineration.Mildly bitter flavor, puckery; Property is put down.Function cures mainly: dampness removing, heat clearing away, detoxifcation.Control enteritis, diarrhea, dysentery, jaundice, hemorrhoid.
Herba polygoni hydropiperis: the dry herb of polygonaceae plant Folium Salicis Babylonicae knotweed Polygonum lapathifolium L.var.salicifolium Sibth..Summer, two seasons of autumn gather, and remove impurity, cleaning, drying.The property hot, temperature.Return lung, liver, large intestine channel.Function cures mainly: reducing swelling and alleviating pain.Control swollen intestinal, dysentery stomachache.
Animal described in the present invention is preferably cattle, sheep, pig or poultry; Described poultry is preferably chicken, duck or goose.
The crude drug of respectively distinguishing the flavor of that the present invention is used can be bought at pharmacy and obtain.
Required various adjuvants were prepared into any oral formulations that is suitable for clinically animal with the method for Chinese medicinal of routine when medicine activity component of the present invention can add the dosage form for preparing oral formulations, such as being powder, granule or oral liquid etc.
Thus, the invention provides a kind of method for preparing described Chinese medicine composition, comprising:
(1) takes by weighing each component by described weight portion;
(2) with each component mix homogeneously, pulverize, sieve (can be the 60-800 mesh sieve for example, be preferably the 80-200 order), and get final product.
The another kind of preparation method of Chinese medicine composition of the present invention:
(1) takes by weighing each component by described weight portion;
(2) water behind the component crushing screening is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and get final product.
Wherein will boil 2-4 time with 3-8 times of weight decocting behind each component crushing screening in the step (2), decocted 1.5 hours at every turn.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as the diarrhoea degree of concrete dosage form, animal and kind.As guidance: for powder, the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 0.5g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not consisted of any restriction.It will be understood by those skilled in the art that lower without departing from the spirit and scope of the present invention and can make amendment or replace the details of technical solution of the present invention and form, but these modifications and replacing all fall within the scope of protection of the present invention.
The preparation of embodiment 1 powder
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Bruceae 25, the Fructus Chebulae 10, Fructus Tsaoko 6, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8;
(2) with each component mix homogeneously, pulverize, cross 100 mesh sieves, and get final product.
The preparation of embodiment 2 powders
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Bruceae 20, the Fructus Chebulae 8, Fructus Tsaoko 4, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6;
(2) with each component mix homogeneously, pulverize, cross 80 mesh sieves, and get final product.
The preparation of embodiment 3 powders
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Bruceae 40, the Fructus Chebulae 25, Fructus Tsaoko 10, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15;
(2) with each component mix homogeneously, pulverize, cross 120 mesh sieves, and get final product.
The preparation of embodiment 4 powders
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 20, Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, the Fructus Chebulae 8, Herba polygoni hydropiperis 8, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6, Cortex Querci Mongolicae 4, Fructus Tsaoko 4, Herba Andrographis 3, Folium Isatidis 3;
(2) with each component mix homogeneously, pulverize, cross 120 mesh sieves, and get final product.
The preparation of embodiment 5 powders
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 40, Radix Rosae Normalis 10-30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, the Fructus Chebulae 25, Herba polygoni hydropiperis 25, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15, Cortex Querci Mongolicae 10, Fructus Tsaoko 10, Herba Andrographis 8, Folium Isatidis 8;
(2) with each component mix homogeneously, pulverize, cross 80 mesh sieves, and get final product.
The preparation of embodiment 6 powders
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 25, Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, the Fructus Chebulae 10, Herba polygoni hydropiperis 10, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8, Cortex Querci Mongolicae 6, Fructus Tsaoko 6, Herba Andrographis 4, Folium Isatidis 4;
(2) with each component mix homogeneously, pulverize, cross 120 mesh sieves, and get final product.
The preparation of embodiment 7 granules
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, Fructus Bruceae 25, the Fructus Chebulae 10, Fructus Tsaoko 6, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8;
(2) with each component mix homogeneously, boil 3 times with the decocting of 6 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The preparation of embodiment 8 granules
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Fructus Bruceae 20, the Fructus Chebulae 8, Fructus Tsaoko 4, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6;
(2) with each component mix homogeneously, boil 2 times with the decocting of 8 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The preparation of embodiment 9 granules
(1) by described weight take by weighing each component (unit: g): Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, Fructus Bruceae 40, the Fructus Chebulae 25, Fructus Tsaoko 10, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15;
(2) with each component mix homogeneously, boil 3 times with the decocting of 5 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The preparation of embodiment 10 granules
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 20, Radix Rosae Normalis 10, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, the Fructus Chebulae 8, Herba polygoni hydropiperis 8, Fructus Schisandrae Chinensis 6, Flos Lonicerae 6, Cortex Querci Mongolicae 4, Fructus Tsaoko 4, Herba Andrographis 3, Folium Isatidis 3;
(2) with each component mix homogeneously, boil 3 times with the decocting of 5 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The preparation of embodiment 11 granules
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 40, Radix Rosae Normalis 30, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 30, the Fructus Chebulae 25, Herba polygoni hydropiperis 25, Fructus Schisandrae Chinensis 15, Flos Lonicerae 15, Cortex Querci Mongolicae 10, Fructus Tsaoko 10, Herba Andrographis 8, Folium Isatidis 8;
(2) with each component mix homogeneously, boil 3 times with the decocting of 5 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The preparation of embodiment 12 granules
(1) by described weight take by weighing each component (unit: g): Fructus Bruceae 25, Radix Rosae Normalis 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15, the Fructus Chebulae 10, Herba polygoni hydropiperis 10, Fructus Schisandrae Chinensis 8, Flos Lonicerae 8, Cortex Querci Mongolicae 6, Fructus Tsaoko 6, Herba Andrographis 4, Folium Isatidis 4;
(2) with each component mix homogeneously, boil 3 times with the decocting of 5 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, will obtain dried cream powder after the thick paste spray drying, adds the adjuvant of preparations shaping, granulation, and get final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating animal diarrhoea of the present invention
One, physical data: accepted the pig that 160 examples suffer from diarrhoea for medical treatment.The 160 routine pigs of accepting for medical treatment all in various degree show that lassitude, loss of appetite, body temperature change, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meet the diagnostic criteria of clinical animal diarrhoea.160 routine pigs are divided into two groups at random, every group of each 80 example.
Two, trial drug
The medicine that embodiment of the invention 1-12 is prepared.
Three, Therapeutic Method
160 pigs that suffer from diarrhoea are divided into 2 groups at random, that is: test 2 groups of 1 group and tests, every group of each 80 example.Test 1 group and adopt the prepared Drug therapy of embodiment 1-3, test 2 groups and adopt the prepared Drug therapy of embodiment 4-6.Inactive other related drugs and other treatment during the treatment.
Powder: the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 0.5g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get and gavage the corresponding 1kg infected animal of 0.5g medicated powder body weight after the granule boiled water soaks; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, the symptom of diarrhea complete obiteration, it is normal that function is recovered fully.
Significantly: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and it is normal that function is recovered substantially.
Effectively: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result sees Table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating diarrhea of pigs of the present invention
With 2-3 days of traditional Chinese medicine composition for treating pig of the present invention, the symptom that great majority are treated diarrhea of pigs all had obviously and alleviates; Treated 3-4 days, and treated the symptom of diarrhea of pigs and significantly improve; By the 5th day for the treatment of, the symptom of diarrhea of pigs disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention is evident in efficacy for diarrhea of pigs; In whole therapeutic process, do not observe the animal that is treated and any untoward reaction occurs, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 2 traditional Chinese medicine composition for treating chicken diarrheas of the present invention
One, physical data: accepted the chicken that 196 examples suffer from diarrhoea for medical treatment.The 196 routine chickens of accepting for medical treatment all in various degree show that lassitude, loss of appetite, body temperature change, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meet the diagnostic criteria of clinical animal diarrhoea.196 chickens are divided into two groups at random, every group of each 98 example.
Two, trial drug
The medicine that embodiment of the invention 1-12 is prepared.
Three, Therapeutic Method
Every kind of animal is divided into 2 groups at random, that is: tests 2 groups of 1 group and tests, each 98 example of every group of chicken.Test 1 group and adopt embodiment 1-3(or embodiment 7-9) prepared Drug therapy, test 2 groups and adopt embodiment 4-6(or embodiment 10-12) prepared Drug therapy.Inactive other related drugs and other treatment during the treatment.
Powder: the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 0.5g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get and gavage the corresponding 1kg infected animal of 0.5g medicated powder body weight after the granule boiled water soaks; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, the symptom of diarrhea complete obiteration, it is normal that function is recovered fully.
Significantly: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and it is normal that function is recovered substantially.
Effectively: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result sees Table 2.
The clinical observation on the therapeutic effect result of the test of table 2 traditional Chinese medicine composition for treating chicken diarrhea of the present invention
With the 2nd day of traditional Chinese medicine composition for treating animal of the present invention, the symptom that great majority are treated chicken diarrhea all had obviously and alleviates; Treated 3-4 days, and treated the symptom of chicken diarrhea and significantly improve; By the 5th day for the treatment of, the symptom of chicken diarrhea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention is evident in efficacy for chicken diarrhea; In whole therapeutic process, do not observe the animal that is treated and any untoward reaction occurs, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 3 traditional Chinese medicine composition for treating animal diarrhoea of the present invention
One, physical data: accepted the cattle that 120 examples suffer from diarrhoea for medical treatment.The 120 routine cattle of accepting for medical treatment all in various degree show that lassitude, loss of appetite, body temperature change, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meet the diagnostic criteria of clinical animal diarrhoea.The Niu Suiji that 120 examples is suffered from diarrhoea is divided into two groups, every group of each 60 example.
Two, trial drug
The medicine that embodiment of the invention 1-12 is prepared.
Three, Therapeutic Method
Every kind of animal is divided into 2 groups at random, that is: tests 2 groups of 1 group and tests, each 60 example of every group of cattle.Test 1 group and adopt embodiment 1-3(or embodiment 7-9) prepared Drug therapy, test 2 groups and adopt embodiment 4-6(or embodiment 10-12) prepared Drug therapy.Inactive other related drugs and other treatment during the treatment.
Powder: the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 0.5g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get and gavage the corresponding 1kg infected animal of 0.5g medicated powder body weight after the granule boiled water soaks; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, the symptom of diarrhea complete obiteration, it is normal that function is recovered fully.
Significantly: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and it is normal that function is recovered substantially.
Effectively: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result sees Table 3.
The clinical observation on the therapeutic effect result of the test of table 3 traditional Chinese medicine composition for treating cattle diarrhoea of the present invention
With the 2nd day of traditional Chinese medicine composition for treating cattle of the present invention, the symptom that great majority are treated cattle diarrhoea all had obviously and alleviates; Treated the 3rd day, and treated the symptom of cattle diarrhoea and significantly improve; By the 5th day for the treatment of, the symptom of cattle diarrhoea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention is evident in efficacy for cattle diarrhoea; In whole therapeutic process, do not observe the animal cattle that is treated and any untoward reaction occurs, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The clinical observation on the therapeutic effect test of test example 4 traditional Chinese medicine composition for treating sheep diarrheas of the present invention
One, physical data: accepted the sheep that 120 examples suffer from diarrhoea for medical treatment.The 120 routine sheep of accepting for medical treatment all in various degree show that lassitude, loss of appetite, body temperature change, Excreta is magma sample or water sample or is mixed with mucus, blood etc., meet the diagnostic criteria of clinical animal diarrhoea.120 routine sheep are divided into 2 groups at random, every group of each 60 example.
Two, trial drug
The medicine that embodiment of the invention 1-12 is prepared.
Three, Therapeutic Method
Every kind of animal is divided into 2 groups at random, that is: tests 2 groups of 1 group and tests, each 60 example of every group of sheep.Test 1 group and adopt embodiment 1-3(or embodiment 7-9) prepared Drug therapy, test 2 groups and adopt embodiment 4-6(or embodiment 10-12) prepared Drug therapy.Inactive other related drugs and other treatment during the treatment.
Powder: the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 0.5g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of; Granule: get and gavage the corresponding 1kg infected animal of 0.5g medicated powder body weight after the granule boiled water soaks; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: after treating 2 courses for the treatment of, the symptom of diarrhea complete obiteration, it is normal that function is recovered fully.
Significantly: after treating 2 courses for the treatment of, symptom of diarrhea disappears substantially, and it is normal that function is recovered substantially.
Effectively: after treating 2 courses for the treatment of, symptom of diarrhea alleviates to some extent, and function is recovered to some extent.
Invalid: after treating 2 courses for the treatment of, symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result sees Table 4.
The clinical observation on the therapeutic effect result of the test of table 4 traditional Chinese medicine composition for treating sheep diarrhea of the present invention
Suffer from diarrhoea the 2nd day of sheep with traditional Chinese medicine composition for treating of the present invention, the symptom that great majority are treated sheep diarrhea all has obviously and alleviates; Treated the 3rd day, and treated the symptom of sheep diarrhea and significantly improve; By the 5th day for the treatment of, the symptom of sheep diarrhea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention is evident in efficacy for sheep diarrhea; In whole therapeutic process, do not observe the sheep that is treated and any untoward reaction occurs, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (10)
1. a Chinese medicine composition for the treatment of animal diarrhoea is characterized in that, comprises that each component of following weight portion forms: Fructus Bruceae 20-40 part, Radix Rosae Normalis 10-30 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-30 part, Fructus Chebulae 8-25 part, Fructus Schisandrae Chinensis 6-15 part, Flos Lonicerae 6-15 part, Fructus Tsaoko 4-10 part.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that, the weight portion of each component is: Fructus Bruceae 20-35 part, Radix Rosae Normalis 10-20 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part, Fructus Chebulae 8-15 part, Fructus Schisandrae Chinensis 6-10 part, Flos Lonicerae 6-10 part, Fructus Tsaoko 4-8 part.
3. according to Chinese medicine composition claimed in claim 1, it is characterized in that, the weight portion of each component is: 25 parts of Fructus Bruceaes, 15 parts of Radix Rosae Normaliss, 15 parts of Herba Desmodii Triquetri (Herba Tadehagi Triquetri)s, 10 parts of Fructus Chebulaes, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Flos Loniceraes, 6 parts of Fructus Tsaokos.
4. treat the Chinese medicine composition that animal is suffered from diarrhoea for one kind, each component that comprises following weight portion forms: Radix Rosae Normalis 10-30 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-30 part, Herba Andrographis 3-8 part, Folium Isatidis 3-8 part, Fructus Bruceae 20-40 part, Fructus Chebulae 8-25 part, Herba polygoni hydropiperis 8-25 part, Fructus Schisandrae Chinensis 6-15 part, Flos Lonicerae 6-15 part, Cortex Querci Mongolicae 4-10 part and Fructus Tsaoko 4-10 part.
5. according to Chinese medicine composition claimed in claim 4, it is characterized in that, the weight portion of each component is: 15 parts of Radix Rosae Normaliss, 15 parts of Herba Desmodii Triquetri (Herba Tadehagi Triquetri)s, 4 parts of Herba Andrographis, 4 parts of Folium Isatidiss, 25 parts of Fructus Bruceaes, 10 parts of Fructus Chebulaes, 10 parts of Herba polygoni hydropiperiss, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Flos Loniceraes, 6 parts of Cortex Querci Mongolicaes, 6 parts of Fructus Tsaokos.
6. according to any one described Chinese medicine composition of claim 1-5, it is characterized in that: it is prepared into clinically acceptable suitable for oral administration preparation of any animal; Preferably, described oral formulations is powder, granule or oral liquid.
7. method for preparing any one described Chinese medicine composition of claim 1-5 may further comprise the steps:
(1) takes by weighing each component by described weight portion;
(2) each component is pulverized, sieved, and get final product.
8. method for preparing any one described Chinese medicine composition of claim 1-5 may further comprise the steps:
(1) takes by weighing each component by described weight portion;
(2) water behind the component crushing screening is decocted, decoction liquor is filtered, and filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and get final product.
9. any one described Chinese medicine composition of claim 1-5 is preparing the purposes for the treatment of in the animal diarrhoea medicine.
10. according to purposes claimed in claim 9, it is characterized in that: described animal is cattle, sheep, pig or poultry; Described poultry is chicken, duck or goose.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013746A (en) * | 2014-06-05 | 2014-09-03 | 湖州天健兽药有限公司 | Traditional Chinese medicine composition for treating piglet diarrhea |
| CN105560403A (en) * | 2014-10-14 | 2016-05-11 | 天津中敖生物科技有限公司 | Chinese medicinal composition for treatment of animal diarrhea and preparation method thereof |
| CN106804953A (en) * | 2017-03-14 | 2017-06-09 | 韦煜康 | Prevent and treat the feed addictive and preparation method of pig epidemic diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641445A (en) * | 2012-04-08 | 2012-08-22 | 张红 | Medicine for treating dysentery and preparing method thereof |
| CN103041048A (en) * | 2012-12-21 | 2013-04-17 | 姜凤丽 | Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641445A (en) * | 2012-04-08 | 2012-08-22 | 张红 | Medicine for treating dysentery and preparing method thereof |
| CN103041048A (en) * | 2012-12-21 | 2013-04-17 | 姜凤丽 | Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013746A (en) * | 2014-06-05 | 2014-09-03 | 湖州天健兽药有限公司 | Traditional Chinese medicine composition for treating piglet diarrhea |
| CN105560403A (en) * | 2014-10-14 | 2016-05-11 | 天津中敖生物科技有限公司 | Chinese medicinal composition for treatment of animal diarrhea and preparation method thereof |
| CN106804953A (en) * | 2017-03-14 | 2017-06-09 | 韦煜康 | Prevent and treat the feed addictive and preparation method of pig epidemic diarrhea |
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