CN103263654B - Medicine for treating lobar pneumonia and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating lobar pneumonia and a preparation method thereof. The medicine disclosed by the invention is mainly prepared from the following medicines according to a certain weight ratio: folia perillae acutae, dried tangerine or orange peel, ephedra, almond, cinnamon, mint, pericarpium arecae, convolvulate asiabell root and the like. The medicine disclosed by the invention has the functions of dispelling the wind, benefiting lung, clearing heat, moistening dryness, warming lung, reducing phlegm, nourishing yin, decreasing internal heat, tonifying qi and nourishing yin; in addition, for treating lobar pneumonia, the medicine disclosed by the invention is quick-acting, high in curative rate and free from recurrence.

Description

A kind of medicine for the treatment of lobar pneumonia and preparation method thereof

Technical field

The present invention relates to medicine of a kind of lobar pneumonia and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Pneumonopathy refers under the impact of the factor such as diseases caused by exogenous pathogenic factor or internal injury, causes a class disease of lungs functional disorder and pathological change.Lung is the canopy of the five internal organs, and its position is the highest, outer conjunction fur, lung being a delicate viscus, not resistance to cold and heat, is again respectful clearly dirty, does not allow foreign body, therefore diseases caused by exogenous pathogenic factor and internal injury factor all easily trauma lungs and cause pathological changes.Lung governing qi, department breathes, therefore pneumonopathy is main mainly with the syndrome that ascending or descending movement of vital Qi is not normal, and its common syndrome has lung qi virtual loss, cloudy body fluid deficiency consumption, pathogenic cold attacking the lung, pathogenic heat to take advantage of lung, turbid phlegm obstructing in the lung etc.Pneumonopathy brings serious harm to people's physical and mental health, has had a strong impact on people's daily life and work.At present, because Western medicine effectively cannot treat lobar pneumonia, and have a lot of side effect, therefore, there is very large demand to the Chinese medicine of rapid, effective treatment lobar pneumonia in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment lobar pneumonia, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine of effective treatment lobar pneumonia.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Folium Perillae, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae and Rhizoma Zingiberis greatly combines, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of lobar pneumonia.Folium Perillae is wherein selected to be that temperature, enters lung, spleen channel, deliver, cold expelling, regulate the flow of vital energy because its nature and flavor are pungent, and the function of battalion, cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement, and can solving toxin of fish and crab.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Herba Ephedrae is selected to be that temperature, enters lung, urinary bladder channel, have diaphoresis, relieving asthma because its nature and flavor are worked hard, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache nasal obstruction, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Semen Armeniacae Amarum is selected to be that temperature, poisonous, enter lung, large intestine channel, have expelling phlegm for arresting cough, relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation because its nature and flavor are bitter.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Fructus Mume is selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.Selecting and flying greatly poplar is because its nature and flavor are pained, and dry, have clearing heat and moistening lung, the function of dehumidifying parasite killing, controls pertussis, cardiopalmus, insomnia.Radix Codonopsis convolvulaceae is selected to be that flat, have lung moistening, the function of promoting the production of body fluid, controls pulmonary tuberculosis, tracheitis because its nature and flavor are sweet.Select Herba Stachydis Japonicae to be because its property and flavor of peppery and warm, have dispelling wind to regulate the flow of vital energy, hemostasis, the function of antiinflammatory, controls consumptive lung disease, lung abscess, halitosis, pharyngalgia.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Folium Perillae 10-15 gram of Pericarpium Citri Reticulatae 8-12 gram of Herba Ephedrae 6-10 gram

Semen Armeniacae Amarum 8-12 gram of Cortex Cinnamomi 8-12 gram of Herba Menthae 8-12 gram

Pericarpium Arecae 12-20 gram of Cortex Mori 15-25 gram of Radix Glycyrrhizae 8-12 gram

Fructus Mume 12-16 gram flies greatly poplar 15-25 Keshan egg 15-25 gram

Herba Stachydis Japonicae 10-20 gram of Rhizoma Zingiberis 6-10 gram

Wherein, be preferably

8 grams, Folium Perillae 12 grams of Pericarpium Citri Reticulataes 10 grams of Herba Ephedraes

Semen Armeniacae Amarum 10 grams of Cortex Cinnamomis 10 grams of Herba Menthaes 10 grams

10 grams, Pericarpium Arecae 18 grams of Cortex Mori 20 grams of Radix Glycyrrhizaes

Fructus Mume 15 grams flies greatly 20 grams, poplar 20 Keshan egg

Herba Stachydis Japonicae 15 grams of Rhizoma Zingiberiss 8 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Folium Perillae: pick decontamination, dries;

2, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

3, Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, and cutting after micro-profit, is drying to obtain;

4, Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

5, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

6, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

7, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;

8, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

9, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

10, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

11, fly poplar greatly: Xia Qiu gathers, dry;

12, Radix Codonopsis convolvulaceae: winter gathers, cleans, dries;

13, Herba Stachydis Japonicae: the 7-8 month gathers, and dries;

14, Rhizoma Zingiberis: pick clean impurity, be soaked in water 3-6 hour, pulls out, cuts into slices after moistening, dries.

Two, prepare

1, by the Folium Perillae of described weight, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar greatly, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae, Rhizoma Zingiberis decoct with water, add water 6 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, obtain first time decoction liquor.

2, add water medicinal residues after first time filtration 3 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling.

3, by twice decoction liquor mixing, then simmer in water 10 minutes, liquid will be boiled and be divided into 2 doses.

Medicine of the present invention has the easy lung that dispels the wind, clearing heat and moistening dryness, warming the lung for resolving phlegm, nourishing YIN to lower pathogenic fire, effect of supplementing QI and nourishing YIN, and treatment lobar pneumonia instant effect, cure rate is high, does not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 10, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 200 example for medical treatment, its mild or moderate lobar pneumonia 80 example, middle severe lobar pneumonia 120 example.

2, diagnostic criteria

Slight lobar pneumonia: whistling sound in the throat when main manifestations is outbreak, tachypnea and dyspnea, very then failing to lie flat due to dyspnea.Clinical in cough, to cough up phlegm as main manifestations.

Middle severe lobar pneumonia: to cough, to spit blood, chest pain, heating, the malignant disease for main manifestations out of breath.Clinical manifestation is tachypnea of panting, cough, and cough up phlegm, chest is swollen full, feels oppressed as plug, or cyanosis of the lips and nails, cardiopalmus edema etc.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, slight lobar pneumonia is each serving with 1 dose, and every day early, evening respectively takes 1 time, within 20 days, is a course for the treatment of, takes two courses for the treatment of continuously.Severe lobar pneumonia is each serving with 1 dose, and every day is early, middle and late respectively takes 1 time, within 20 days, is a course for the treatment of, takes four courses for the treatment of continuously.

4, efficacy assessment standard

Effective: clinical symptom disappearance after treatment, body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical part transference cure or without change, do not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by slight lobar pneumonia patient 80 example of Drug therapy of the present invention, wherein effective 75 examples, take a turn for the better 4 examples, and invalid 1 example, obvious effective rate is 93.75%, and improvement rate is 5%, and total effective rate is 98.75%.Severe lobar pneumonia patient 120 example in treatment, wherein effective 110 examples, take a turn for the better 4 examples, and invalid 6 examples, obvious effective rate is 91.67%, and improvement rate is 3.33%, and total effective rate is 95%.

Claims (3)

1. treat a medicine for lobar pneumonia, it is characterized in that: it is made up of the crude drug in following weight range:

Folium Perillae 10-15 gram of Pericarpium Citri Reticulatae 8-12 gram of Herba Ephedrae 6-10 gram

Semen Armeniacae Amarum 8-12 gram of Cortex Cinnamomi 8-12 gram of Herba Menthae 8-12 gram

Pericarpium Arecae 12-20 gram of Cortex Mori 15-25 gram of Radix Glycyrrhizae 8-12 gram

Fructus Mume 12-16 gram flies greatly poplar 15-25 Keshan egg 15-25 gram

Herba Stachydis Japonicae 10-20 gram of Rhizoma Zingiberis 6-10 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

8 grams, Folium Perillae 12 grams of Pericarpium Citri Reticulataes 10 grams of Herba Ephedraes

Semen Armeniacae Amarum 10 grams of Cortex Cinnamomis 10 grams of Herba Menthaes 10 grams

10 grams, Pericarpium Arecae 18 grams of Cortex Mori 20 grams of Radix Glycyrrhizaes

Fructus Mume 15 grams flies greatly 20 grams, poplar 20 Keshan egg

Herba Stachydis Japonicae 15 grams of Rhizoma Zingiberiss 8 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Folium Perillae: pick decontamination, dries;

(2) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(3) Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, and cutting after micro-profit, is drying to obtain;

(4) Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

(5) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

(6) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

(7) Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;

(8) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

(9) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

(10) Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

(11) fly poplar greatly: Xia Qiu gathers, dry;

(12) Radix Codonopsis convolvulaceae: winter gathers, cleans, dries;

(13) Herba Stachydis Japonicae: the 7-8 month gathers, and dries;

(14) Rhizoma Zingiberis: pick clean impurity, be soaked in water 3-6 hour, pulls out, cuts into slices after moistening, dries;

(2) prepare

(1) by the Folium Perillae of described weight, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar greatly, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae, Rhizoma Zingiberis decoct with water, add water 6 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, obtain first time decoction liquor;

(2) add water medicinal residues after first time filtration 3 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling;

(3) by twice decoction liquor mixing, then simmer in water 10 minutes, liquid will be boiled and be divided into 2 doses.