CN103330861B - Medicine for curing cholera and preparation method thereof - Google Patents
Medicine for curing cholera and preparation method thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses medicine for curing cholera and a preparation method thereof. The medicine is mainly prepared from the following raw materials in a certain weight proportion: agastache rugosus, fructus perillae, radix angelicae, platycodon roots, pericarpium arecae and mangnolia officinalis. The medicine has the functions of regulating qi-flowing for strengthening spleen, drying dampness for resolving phlegm, eliminating dampness for diuresis and removing pathogenic heat from blood, is used for curing cholera, and has the advantages of instant effect, good curative effect and high curative ratio.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cholera and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Cholera is with vomiting and dirarrhea, stomachache or not bitterly for the disease of feature, this disease is mainly in summer and autumn, experiences heat-damp in summer, the foul gas of cold temperature and unhygienic diet, cause taste injured, disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, qi-movement disturbance and vomit and diarrhoea hand over do, there is the excessive forfeiture of body fluid at short notice and cause.At present, western medicine cholera poor effect, and have more side effect.Therefore, there is very large demand to the Chinese medicine of rapid, effective treatment cholera in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment cholera, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating cholera.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Pogostemonis, Fructus Perillae, the Radix Angelicae Dahuricae, Radix Platycodonis, Pericarpium Arecae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Caulis Bambusae In Taenia, Semen Lablab Album, Radix Paeoniae Alba, Radix Rehmanniae medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of cholera.Herba Pogostemonis is wherein selected to be that tepor, enters lung, spleen, stomach warp, have fast gas because its nature and flavor are pungent, and in, ward off dirty, the function of damp eliminating, cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.Fructus Perillae is selected to be that temperature, enter lung, large intestine channel, have the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation because its nature and flavor are pungent.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Select Cortex Magnoliae Officinalis to be because its nature and flavor toil, temperature, enter spleen, stomach, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria, edema distension, phlegm retention cough with dyspnea, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select Semen Lablab Album to be that tepor, returns spleen, stomach warp, have invigorating the spleen for eliminating dampness because its nature and flavor are sweet, and in the function of relieving summer heat, control weakness of the spleen and stomach, inappetence, diarrhea, leukorrhagia, heat-damp in summer is vomited and diarrhoea, abdominal distention uncomfortable in chest.Select Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Herba Pogostemonis 10-20 gram of Fructus Perillae 10-20 gram of Radix Angelicae Dahuricae 10-20 gram
Radix Platycodonis 10-20 gram of Pericarpium Arecae 8-12 gram Cortex Magnoliae Officinalis 8-12 gram
Pericarpium Citri Reticulatae 8-12 gram of Rhizoma Pinelliae 8-12 gram of Poria 10-20 gram
Rhizoma Atractylodis Macrocephalae 10-20 gram of Radix Glycyrrhizae 8-12 gram of Caulis Bambusae In Taenia 10-20 gram
Semen Lablab Album 8-12 gram of Radix Paeoniae Alba 8-12 gram of Radix Rehmanniae 8-12 gram
Preferable amount is
Herba Pogostemonis 15 grams of Fructus Perillaes 15 grams of Radixs Angelicae Dahuricae 15 grams
Radix Platycodonis 15 grams of Pericarpium Arecae 10 grams of Cortex Magnoliae Officinalis 10 grams
15 grams, Pericarpium Citri Reticulatae 10 grams of Rhizoma Pinelliaes 10 grams of Poria
The Rhizoma Atractylodis Macrocephalae 15 grams of Radix Glycyrrhizaes 10 grams of Caulis Bambusae In Taenia 15 grams
Semen Lablab Album 10 grams of Radix Paeoniae Alba 10 grams of Radix Rehmanniae 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;
2, Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;
3, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
4, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;
5, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
6, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;
7, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
8, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
9, Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
10, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
11, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
12, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;
13, Semen Lablab Album: get crude drug, remove mould, moth Semen Lablab Album grain and impurity, the used time smashs to pieces;
14, Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
15, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip.
Two, prepare
1, the Herba Pogostemonis of described weight, Fructus Perillae, the Radix Angelicae Dahuricae, Radix Platycodonis, Pericarpium Arecae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Caulis Bambusae In Taenia, Semen Lablab Album, Radix Paeoniae Alba, Radix Rehmanniae 15 herbal medicine are decocted with water secondary, each amount of water was advisable not have powder, merge twice decoction liquor, filter to get filtrate, be condensed into the extractum that proportion is 1.35, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract.
2, dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule, be divided into two doses to take.
Medicine of the present invention has heat-clearing and toxic substances removing, and warming spleen and stomach for dispelling cold dispels the wind, and dehumidifying, effect of pain relieving, is used for the treatment of cholera short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy cholera of the present invention
1, physical data
Accept out-patient's totally 280 examples for medical treatment, its male patient 120 example, female patient 160 example.
2, diagnostic criteria
Clinical manifestation: limbs of patient asthenia, tastelessness lack of appetite, stomachache is vomited and diarrhoea, and not yearningly, hot urination, lassitude, pale tongue with white fur is sliding, and deep-slow pulse is unable.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 5 days, is a course for the treatment of, takes 2 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: cholera transference cure, body constitution recovers normal;
Take a turn for the better: cholera symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy cholera patients 280 example of the present invention, effective 270 examples of result, obvious effective rate is 96.43%, and take a turn for the better 6 examples, and improvement rate is 2.14%, and invalid 4 examples, total effective rate is 98.57%.
Claims (3)
1. treat a medicine for cholera, it is characterized in that: it is made up of the crude drug in following weight range:
Herba Pogostemonis 10-20 gram of Fructus Perillae 10-20 gram of Radix Angelicae Dahuricae 10-20 gram
Radix Platycodonis 10-20 gram of Pericarpium Arecae 8-12 gram Cortex Magnoliae Officinalis 8-12 gram
Pericarpium Citri Reticulatae 8-12 gram of Rhizoma Pinelliae 8-12 gram of Poria 10-20 gram
Rhizoma Atractylodis Macrocephalae 10-20 gram of Radix Glycyrrhizae 8-12 gram of Caulis Bambusae In Taenia 10-20 gram
Semen Lablab Album 8-12 gram of Radix Paeoniae Alba 8-12 gram of Radix Rehmanniae 8-12 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Pogostemonis 15 grams of Fructus Perillaes 15 grams of Radixs Angelicae Dahuricae 15 grams
Radix Platycodonis 15 grams of Pericarpium Arecae 10 grams of Cortex Magnoliae Officinalis 10 grams
15 grams, Pericarpium Citri Reticulatae 10 grams of Rhizoma Pinelliaes 10 grams of Poria
The Rhizoma Atractylodis Macrocephalae 15 grams of Radix Glycyrrhizaes 10 grams of Caulis Bambusae In Taenia 15 grams
Semen Lablab Album 10 grams of Radix Paeoniae Alba 10 grams of Radix Rehmanniae 10 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;
(2) Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;
(3) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
(4) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;
(5) Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
(6) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;
(7) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
(8) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
(9) Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
(10) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(11) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(12) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;
(13) Semen Lablab Album: get crude drug, remove mould, moth Semen Lablab Album grain and impurity, the used time smashs to pieces;
(14) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(15) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
(2) prepare
(1) Herba Pogostemonis of described weight, Fructus Perillae, the Radix Angelicae Dahuricae, Radix Platycodonis, Pericarpium Arecae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Caulis Bambusae In Taenia, Semen Lablab Album, Radix Paeoniae Alba, Radix Rehmanniae 15 herbal medicine are decocted with water secondary, each amount of water was advisable not have powder, merge twice decoction liquor, filter to get filtrate, be condensed into the extractum that proportion is 1.35, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(2) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule, be divided into two doses to take.
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