CN103263654A

CN103263654A - Medicine for treating lobar pneumonia and preparation method thereof

Info

Publication number: CN103263654A
Application number: CN2013102129031A
Authority: CN
Inventors: 肖变化
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-06-03
Filing date: 2013-06-03
Publication date: 2013-08-28
Anticipated expiration: 2033-06-03
Also published as: CN103263654B

Abstract

The invention discloses a medicine for treating lobar pneumonia and a preparation method thereof. The medicine disclosed by the invention is mainly prepared from the following medicines according to a certain weight ratio: folia perillae acutae, dried tangerine or orange peel, ephedra, almond, cinnamon, mint, pericarpium arecae, convolvulate asiabell root and the like. The medicine disclosed by the invention has the functions of dispelling the wind, benefiting lung, clearing heat, moistening dryness, warming lung, reducing phlegm, nourishing yin, decreasing internal heat, tonifying qi and nourishing yin; in addition, for treating lobar pneumonia, the medicine disclosed by the invention is quick-acting, high in curative rate and free from recurrence.

Description

A kind of medicine for the treatment of lobar pneumonia and preparation method thereof

Technical field

The present invention relates to medicine of a kind of lobar pneumonia and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Pneumonopathy refers under factor affecting such as diseases caused by exogenous pathogenic factor or internal injury, causes a class disease of lungs functional disorder and pathological change.Lung is the canopy of the five internal organs, and its position is the highest, closes fur outward, lung being a delicate viscus, and cold-resistant heat be again clear respectful dirty, does not allow foreign body, so diseases caused by exogenous pathogenic factor and internal injury factor easy trauma lungs and cause pathological changes all.Lung governing qi, department breathes, so pneumonopathy is many based on the not normal syndrome of ascending or descending movement of vital Qi, its common syndrome has lung qi, and thanks to void, cloudy body fluid deficiency consumption, pathogenic cold attacking the lung, pathogenic heat are taken advantage of lung, turbid phlegm obstructing in the lung etc.Pneumonopathy brings serious harm for people's physical and mental health, has had a strong impact on people's daily life and work.At present, because Western medicine can't effectively be treated lobar pneumonia, and has a lot of side effect, therefore, there is very big demand in people to the Chinese medicine of effectively treating lobar pneumonia fast.

Summary of the invention

The inventor has found the medicine of effective treatment lobar pneumonia finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provides a kind of composition of medicine of effective treatment lobar pneumonia.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicine of the present invention selects Folium Perillae, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae and Rhizoma Zingiberis greatly makes up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of lobar pneumonia.Wherein selecting Folium Perillae for use is that temperature is gone into lung, spleen channel because of its nature and flavor suffering, deliver, and cold expelling, the function of regulating the flow of vital energy and seeking, the wind and cold that cures cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement, and can solving toxin of fish and crab.Selecting Pericarpium Citri Reticulatae for use is that temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged because of its nature and flavor hardship, suffering, and the function of drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select for use Herba Ephedrae to be because its nature and flavor are arduous, temperature is gone into lung, urinary bladder channel, and diaphoresis is arranged, and relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Selecting Semen Armeniacae Amarum for use is because of its nature and flavor hardship, and temperature is poisonous, goes into lung, large intestine channel, and expelling phlegm for arresting cough is arranged, and relievings asthma, and the function of intestine moistening is controlled the exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Selecting Cortex Cinnamomi for use is that heat is gone into kidney, spleen, urinary bladder channel, and the complement sun is arranged, warming the spleen and stomach, removing accumulated cold because of its property acrid-sweet flavor, the function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Selecting Herba Menthae for use is because its nature and flavor suffering, and lung, Liver Channel are gone in cold, and dispelling wind is arranged, and heat radiation is warded off dirtyly, and the function of detoxifcation is controlled affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Selecting Pericarpium Arecae for use is that tepor is gone into spleen, stomach, intestine and small intestine warp, and therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO is arranged because of its nature and flavor suffering, and the function of row water is controlled gastral cavity abdomen painful abdominal mass and expanded beriberi, edema.Select for use Cortex Mori to be because its nature and flavor are sweet, cold, go into lung, spleen channel, eliminating pathogen from the lung for relieving asthma is arranged, the function of line water detumescence is controlled dyspnea and cough due to lung-heat, spits blood edema, beriberi, dysuria.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Selecting Fructus Mume for use is that temperature is gone into liver because of its nature and flavor acid, spleen, and lung, large intestine channel has convergence to promote the production of body fluid, and the function of relieving colic caused by ascaris anthelmintic is controlled chronic cough, the deficiency-heat excessive thirst, chronic malaria, dysentery is had blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Selecting for use and flying poplar greatly is because its nature and flavor bitterness is done, and clearing heat and moistening lung are arranged, and the function of dehumidifying parasite killing is controlled pertussis, cardiopalmus, insomnia.Select for use Radix Codonopsis convolvulaceae to be because its nature and flavor are sweet, flat, lung moistening is arranged, the function of promoting the production of body fluid is controlled pulmonary tuberculosis, tracheitis.Select for use Herba Stachydis Japonicae to be because its property and flavor of peppery and warm has dispelling wind to regulate the flow of vital energy, hemostasis, the function of antiinflammatory is controlled consumptive lung disease, lung abscess, halitosis, pharyngalgia.Selecting Rhizoma Zingiberis for use is because its nature and flavor suffering, and heat is gone into spleen, stomach, lung meridian, and there have warming middle-JIAO to pursue to be cold, and the function that recuperating depleted YANG is promoted blood circulation is controlled trusted subordinate's cold type of pain, vomit and diarrhoea, and the cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.

The specific embodiment

The drug dose of component of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range

Folium Perillae 10-15 gram Pericarpium Citri Reticulatae 8-12 gram Herba Ephedrae 6-10 gram

Semen Armeniacae Amarum 8-12 gram Cortex Cinnamomi 8-12 gram Herba Menthae 8-12 gram

Pericarpium Arecae 12-20 gram Cortex Mori 15-25 gram Radix Glycyrrhizae 8-12 gram

Fructus Mume 12-16 gram flies poplar 15-25 Keshan egg 15-25 gram greatly

Herba Stachydis Japonicae 10-20 gram Rhizoma Zingiberis 6-10 gram

Wherein, be preferably

Folium Perillae 12 gram Pericarpium Citri Reticulataes 10 gram Herba Ephedraes 8 grams

Semen Armeniacae Amarum 10 gram Cortex Cinnamomis 10 gram Herba Menthaes 10 grams

Pericarpium Arecae 18 gram Cortex Mori 20 gram Radix Glycyrrhizaes 10 grams

Fructus Mume 15 grams fly poplar 20 Keshan eggs 20 grams greatly

Herba Stachydis Japonicae 15 gram Rhizoma Zingiberiss 8 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Folium Perillae: choose decontamination, dry;

2, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;

3, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;

4, Semen Armeniacae Amarum: choose clean impurity, put in the boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

5, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

6, Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put earlier, then stem is sprayed clear water, run through the back cutting, dry, again with leaf and even;

7, Pericarpium Arecae: choose clean impurity, backing makes soft, beats, and sieve removes spare;

8, Cortex Mori: brush away the ash bits, clean, run through the back shredding, dry;

9, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;

10, Fructus Mume: choose clean impurity, sieve dedust bits are cleaned, and dry;

11, fly poplar greatly: Xia Qiu gathers, and dries;

12, Radix Codonopsis convolvulaceae: gather winter, cleans, and dries;

13, Herba Stachydis Japonicae: the 7-8 month gathers, and dries;

14, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hour, pull out, cut into slices behind the moistening, dry.

Two, preparation

1, with the Folium Perillae of described weight, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae, Rhizoma Zingiberis greatly and decoct with water, add for the first time 6 times of amounts of water, soak after 90 minutes, intense fire decocts boiling 10 minutes, reuse slow fire boiling 20 minutes, time decoction liquor of namely winning.

2, will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling namely got decoction liquor for the second time in 20 minutes.

3, twice decoction liquor mixed, simmered in water again 10 minutes, will boil liquid and be divided into 2 doses and get final product.

Medicine of the present invention has the easy lung that dispels the wind, clearing heat and moistening dryness, and warming the lung for resolving phlegm, nourishing YIN to lower pathogenic fire, the effect of supplementing QI and nourishing YIN, treatment lobar pneumonia instant effect, the cure rate height does not recur.

Below further set forth the beneficial effect of medicine of the present invention by testing example, these tests comprise that the animal toxicity test of medicine of the present invention and clinical observation test.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 20 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 200 examples for medical treatment, its mild or moderate lobar pneumonia 80 examples, middle severe lobar pneumonia 120 examples.

2, diagnostic criteria

Slight lobar pneumonia: whistling sound in the throat when main performance is outbreak, tachypnea and dyspnea, very then failing to lie flat due to dyspnea.Clinical with the cough, coughing up phlegm is main performance.

In the severe lobar pneumonia: with cough, spitting of blood, chest pain, heating, out of breath serve as the malignant disease that mainly shows.Clinical manifestation is the tachypnea of panting, and cough is coughed up phlegm, and chest is swollen full, feel oppressed as plug, or cyanosis of the lips and nails, cardiopalmus edema etc.

3, Therapeutic Method

Select above-mentioned medicament for use, take to the patient, slight lobar pneumonia is taken 1 dose at every turn, every day early, respectively obey 1 time evening, 20 days is a course for the treatment of, takes two courses for the treatment of continuously.The severe lobar pneumonia is taken 1 dose at every turn, and every day is early, middle and late respectively obeys 1 time, and 20 days is a course for the treatment of, takes four courses for the treatment of continuously.

4, efficacy assessment standard

Produce effects: treatment back clinical symptom disappearance, it is normal that body constitution is recovered, and observes and do not have the recidivist half a year;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with Drug therapy of the present invention slight lobar pneumonia patient's 80 examples, produce effects 75 examples wherein, 4 examples that take a turn for the better, invalid 1 example, obvious effective rate is 93.75%, and improvement rate is 5%, and total effective rate is 98.75%.Severe lobar pneumonia patient 120 examples in the treatment, produce effects 110 examples wherein, 4 examples that take a turn for the better, invalid 6 examples, obvious effective rate is 91.67%, and improvement rate is 3.33%, and total effective rate is 95%.

Claims

1. medicine for the treatment of lobar pneumonia, it is characterized in that: it is to be made by the crude drug in the following weight range:

Fructus Mume 12-16 gram flies poplar 15-25 Keshan egg 15-25 gram greatly

Herba Stachydis Japonicae 10-20 gram Rhizoma Zingiberis 6-10 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Pericarpium Arecae 18 gram Cortex Mori 20 gram Radix Glycyrrhizaes 10 grams

Fructus Mume 15 grams fly poplar 20 Keshan eggs 20 grams greatly

Herba Stachydis Japonicae 15 gram Rhizoma Zingiberiss 8 grams.

3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:

(1) gets the raw materials ready

(1) Folium Perillae: choose decontamination, dry;

(2) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;

(3) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;

(4) Semen Armeniacae Amarum: choose clean impurity, put in the boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

(5) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

(6) Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put earlier, then stem is sprayed clear water, run through the back cutting, dry, again with leaf and even;

(7) Pericarpium Arecae: choose clean impurity, backing makes soft, beats, and sieve removes spare;

(8) Cortex Mori: brush away the ash bits, clean, run through the back shredding, dry;

(9) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;

(10) Fructus Mume: choose clean impurity, sieve dedust bits are cleaned, and dry;

(11) fly poplar greatly: Xia Qiu gathers, and dries;

(12) Radix Codonopsis convolvulaceae: gather winter, cleans, and dries;

(13) Herba Stachydis Japonicae: the 7-8 month gathers, and dries;

(14) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hour, pull out, cut into slices behind the moistening, dry;

(2) preparation

(1) with the Folium Perillae of described weight, Pericarpium Citri Reticulatae, Herba Ephedrae, Semen Armeniacae Amarum, Cortex Cinnamomi, Herba Menthae, Pericarpium Arecae, Cortex Mori, Radix Glycyrrhizae, Fructus Mume, fly poplar, Radix Codonopsis convolvulaceae, Herba Stachydis Japonicae, Rhizoma Zingiberis greatly and decoct with water, add for the first time 6 times of amounts of water, soak after 90 minutes, intense fire decocts boiling 10 minutes, reuse slow fire boiling 20 minutes, time decoction liquor of namely winning;

(2) will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling namely got decoction liquor for the second time in 20 minutes;

(3) twice decoction liquor mixed, simmered in water again 10 minutes, will boil liquid and be divided into 2 doses.