CN106421573A - Drug for treating cough and preparation method thereof - Google Patents

Drug for treating cough and preparation method thereof Download PDF

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Publication number
CN106421573A
CN106421573A CN201611145400.7A CN201611145400A CN106421573A CN 106421573 A CN106421573 A CN 106421573A CN 201611145400 A CN201611145400 A CN 201611145400A CN 106421573 A CN106421573 A CN 106421573A
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radix
gram
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dry
impurity
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兰恒才
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a drug for treating cough and a preparation method thereof; the drug is prepared mainly from Radix Ledebouriellae, Folium Perillae, Herba Schizonepetae, Radix Platycodonis, Radix Asteris, Radix Stemonae and Rhizoma Cynanchi Stauntonii at a certain weight ratio. The drug of the invention has the functions of moistening lung qi, drying dampness and removing phlegm, purging lung and decreasing qi, regulating qi and strengthening spleen, regulating middle warmer and relieving urgency, and dispelling wind and removing dampness, and has high acting speed and good effect for treating cough, with zero recurrence.

Description

A kind of treat medicine of cough and preparation method thereof
Technical field
The present invention relates to a kind of treat medicine of cough and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Cough be human body remove respiratory tract in secretions or foreign body protectiveness respiratory reflex action.Although there being it favourable One side, but violent chronic cough may result in respiratory tract hemorrhage.The traditional Chinese medical science then thinks that cough and the factor such as diseases caused by exogenous pathogenic factor or internal injury lead to lung Lose and declare respectful, abnormal rising of lung-QI, impact air flue, send and cough sound or relevant with coughing up phlegm.Due to western medicine large side effects, therefore people couple There is great demand in the Chinese medicine of effectively cough-relieving, up to now, also do not find the relevant report with regard to the present invention.
Content of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, have found the medicine of effective cough-relieving finally Thing, thus complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment cough.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Radix Saposhnikoviae, Folium Perillae, Herba Schizonepetae, Radix Platycodoniss, Radix Asteriss, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae to carry out group Close preparation, these drug regimens are made each efficacy of drugs produce synergism such that it is able to effective cough-relieving.Wherein, select Radix Saposhnikoviae is because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, and wind-dispelling wins wet, the function of pain relieving, controls diseases caused by exogenous pathogenic factor wind Cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, extremity contraction is anxious, tetanus.It is because that its nature and flavor is pungent from Folium Perillae, Temperature, enters lung, spleen channel, delivers, cold expelling, qi-regulating, and the function of battalion, and cure cold wind and cold, fever with aversion to cold, cough, asthma, and chest and abdomen are swollen Full, frequent fetal movement, and can solving toxin of fish and crab.It is because that its nature and flavor is pungent from Herba Schizonepetae, temperature, enter lung, Liver Channel, deliver, wind-dispelling, treating blood disorderss Function, fries charcoal hemostasis, cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, spit blood, epistaxis, have blood in stool, metrorrhagia, puerperal blood Dizzy, carbuncle, sore scabies, scrofula.It is because its nature and flavor toil from Radix Platycodoniss, put down, enter lung, stomach, have out lung qi dispersing gas, eliminating the phlegm evacuation of pus Function, controls exogenous cough, laryngopharynx swelling and pain, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.It is because that its nature and flavor is bitter from Radix Asteriss, Temperature, enters lung meridian, has warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, the function of antitussive, controls cough due to wind and cold's asthma, and asthenia coughs vomiting bloody pus, sore throat, and urine is not Profit.It is because its nature and flavor sweetness and bitterness, tepor from the Radix Stemonae, enters lung meridian have gentle lung qi, cough-relieving, the function of parasite killing, control wind and cold and cough Cough, pertussis, pulmonary tuberculosis, old cough with asthma, ascarid, enterobiasiss, skin scabies, eczema.It is because its property acrid-sweet flavor from Rhizoma Cynanchi Stauntonii, Tepor, return lung warp, there are eliminating the pathogens from the lung sending down the abnormal ascending QI, the function of lower phlegm and relieving cough, control excess of the lung dyspnea with fullness of the chest, cough, excessive phlegm, gastralgia.From Pericarpium Citri Reticulatae It is because that its nature and flavor is bitter, pungent, temperature, return lung, spleen channel, there are regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, control fullness in the epigastrium and chest, lack of appetite and vomiting, Cough with copious phlegm.It is because that its nature and flavor is sweet flat from Radix Glycyrrhizae, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription Function, process with controlling weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling swelling throat Bitterly, peptic ulcer, ulcer sores, solution poison of drug and alimentary toxicosis.
Specific embodiment
The drug dose of instant component is also that inventor draws through groping in a large number to summarize, and the consumption of each component is following heavy All there is in the range of amount preferable curative effect：
5-15 gram of Radix Saposhnikoviae, 5-15 gram of Folium Perillae, 5-15 gram of Herba Schizonepetae, 5-15 gram of Radix Platycodoniss, 10-20 gram of Radix Asteriss, 10-20 gram of the Radix Stemonae, in vain First 5-15 gram, 5-15 gram of Pericarpium Citri Reticulatae, 3-7 gram of Radix Glycyrrhizae.
It is preferably：
10 grams of Radix Saposhnikoviae, 10 grams of Folium Perillae, 10 grams of Herba Schizonepetae, 10 grams of Radix Platycodoniss, 15 grams of Radix Asteriss, 15 grams of the Radix Stemonae, 10 grams of Rhizoma Cynanchi Stauntonii, Pericarpium Citri Reticulatae 10 Gram, 5 grams of Radix Glycyrrhizae.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Radix Saposhnikoviae：Remove residual stem, be soaked in water, pull out, run through section, dry；
2nd, Folium Perillae：Pick impurity, dry；
3rd, Herba Schizonepetae：Pick net impurity, slightly steeped with water, pull cutting out, dry；
4th, Radix Platycodoniss：Pick net impurity, except removing LU, clean and pull out, cut into slices after running through, dry；
5th, Radix Asteriss：Pick impurity, remove residual stem, clean, slightly moistening, be cut into segment and dry；
6th, the Radix Stemonae：Pick net impurity, remove fibrous root, clean, run through rear cutting, dry；
7th, Rhizoma Cynanchi Stauntonii：Pick impurity, clean soil, pull out after slightly soaking, run through, cutting, dry；
8th, Pericarpium Citri Reticulatae：Take crude drug, remove the peel of impurity and blackening, wash quickly is net, softens, shredding, dries or cold drying, sieve Dedusting is considered to be worth doing；
9th, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant saturating when, pull out, run through, section, dry.
2nd, prepare
1st, the Radix Saposhnikoviae after processing, Folium Perillae, Herba Schizonepetae, Radix Platycodoniss, Radix Asteriss, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are put in decocting container, Add water 6 times amount for the first time, after soaking 60 minutes, fries by intense fire to boil and rises, then with boiling by slow fire 20 minutes, filters to decoct for the first time Liquid, first time decoction liquor is poured in container；
2nd, the medicinal residues of filtration are added 4 times amount, boil by intense fire, then with boiling by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses to take.
In prescription, the Radix Stemonae has gentle lung qi, cough-relieving, and the function of parasite killing is monarch drug；Rhizoma Cynanchi Stauntonii eliminating the pathogens from the lung sending down the abnormal ascending QI, lower phlegm and relieving cough；Pericarpium Citri Reticulatae There are regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, the two is ministerial drug, three taste medicines play gentle lung qi, drying dampness to eliminate phlegm jointly, and eliminating the pathogens from the lung is dropped Gas, the effect of regulating qi-flowing for strengthening spleen, cough-relieving effect comprehensively, and with gentle lung qi, drying dampness to eliminate phlegm, can effect a permanent cure based on eliminating the pathogens from the lung sending down the abnormal ascending QI, Radix Glycyrrhizae Have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription is adjuvant drug, Radix Saposhnikoviae is delivered, wind-dispelling, winning wet function is to make medicine, and remaining Under all medicines be to take stopgap measures.
Medicine of the present invention has gentle lung qi, drying dampness to eliminate phlegm, eliminating the pathogens from the lung sending down the abnormal ascending QI, regulating qi-flowing for strengthening spleen, and middle emergency, expelling wind and dampness Function, for cough-relieving, short treating period, instant effect, non-relapse after healing.
The beneficial effect of of the present invention medicine is expanded on further below by way of test example, these test examples include this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Take rabbit 30, male and female dual-purpose, body weight 2.0 2.5kg, divide two groups, every group 15, one of which is that overdose is tested Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, serve on 7 days, and daily observation is administered reaction, and result shows that two groups of rabbit activities, diet are normal, and medicine is no bad Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept cough out-patient totally 31 for medical treatment.
2nd, diagnostic criteria
Classical symptom is foreign body in bronchus, and abundant expectoration show bubble is uncomfortable in chest, the symptom such as asthma.
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 10 days a course for the treatment of, continuously Take 1 course for the treatment of.
4th, efficacy assessment standard
Effective：Cough symptom disappears, and body constitution recovers normal, recovery from illness；
Take a turn for the better：Patients bronchial's foreign body, abundant expectoration, uncomfortable in chest, the symptom mitigation of asthma, the symptom of cough is clearly better, and body constitution is progressively Recover；
Invalid：Do not reach improvement standard person.
5th, therapeutic outcome（See table）
In above-mentioned treatment, with medicine cough-relieving patient of the present invention 31, effective 27 of result, obvious effective rate is 87.10%, takes a turn for the better 3 Example, improvement rate is 9.67%, invalid 1, and total effective rate is 96.77%.

Claims (3)

1. a kind of medicine treating cough it is characterised in that：It is made up of the crude drug in following weight range：
5-15 gram of Radix Saposhnikoviae, 5-15 gram of Folium Perillae, 5-15 gram of Herba Schizonepetae, 5-15 gram of Radix Platycodoniss, 10-20 gram of Radix Asteriss, 10-20 gram of the Radix Stemonae, in vain First 5-15 gram, 5-15 gram of Pericarpium Citri Reticulatae, 3-7 gram of Radix Glycyrrhizae.
2. medicine according to claim 1, the consumption of wherein each crude drug is：
10 grams of Radix Saposhnikoviae, 10 grams of Folium Perillae, 10 grams of Herba Schizonepetae, 10 grams of Radix Platycodoniss, 15 grams of Radix Asteriss, 15 grams of the Radix Stemonae, 10 grams of Rhizoma Cynanchi Stauntonii. Pericarpium Citri Reticulatae 10 Gram, 5 grams of Radix Glycyrrhizae.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Radix Saposhnikoviae：Remove residual stem, be soaked in water, pull out, run through section, dry；
（2）Folium Perillae：Pick impurity, dry；
（3）Herba Schizonepetae：Pick net impurity, slightly steeped with water, pull cutting out, dry；
（4）Radix Platycodoniss：Pick net impurity, except removing LU, clean and pull out, cut into slices after running through, dry；
（5）Radix Asteriss：Pick impurity, remove residual stem, clean, slightly moistening, be cut into segment and dry；
（6）The Radix Stemonae：Pick net impurity, remove fibrous root, clean, run through rear cutting, dry；
（7）Rhizoma Cynanchi Stauntonii：Pick impurity, clean soil, pull out after slightly soaking, run through, cutting, dry；
（8）Pericarpium Citri Reticulatae：Take crude drug, remove the peel of impurity and blackening, wash quickly is net, softens, shredding, dries or cold drying, Weed out ash bits；
（9）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant saturating when, pull out, run through, section, dry；
（Two）Preparation
（1）Radix Saposhnikoviae after processing, Folium Perillae, Herba Schizonepetae, Radix Platycodoniss, Radix Asteriss, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are put into decocting container Interior, add water 6 times amount, after soaking 60 minutes, fries by intense fire to boil and rises, then with boiling by slow fire 20 minutes, filters to obtain first time decoction liquor, First time decoction liquor is poured in container；
（2）The medicinal residues of filtration are added water 4 times amount, boils by intense fire, then with boiling by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）To decoction liquor mixing and stirring twice, be divided into 2 doses to take.
CN201611145400.7A 2016-12-13 2016-12-13 Drug for treating cough and preparation method thereof Withdrawn CN106421573A (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603975A (en) * 2021-01-13 2021-04-06 湘潭市中心医院 Traditional Chinese medicine granule for clearing lung heat and relieving cough, preparation method and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101077401A (en) * 2006-05-22 2007-11-28 霍承宝 Method for treating exogenous cough
CN102657804A (en) * 2012-05-21 2012-09-12 深圳市齐旺投资有限公司 Traditional Chinese medical composition for treatment of viral influenza and preparation method thereof
CN104186861A (en) * 2014-09-13 2014-12-10 刘秀珠 Chinese herbal tea for treating wind-cold caused cough

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101077401A (en) * 2006-05-22 2007-11-28 霍承宝 Method for treating exogenous cough
CN102657804A (en) * 2012-05-21 2012-09-12 深圳市齐旺投资有限公司 Traditional Chinese medical composition for treatment of viral influenza and preparation method thereof
CN104186861A (en) * 2014-09-13 2014-12-10 刘秀珠 Chinese herbal tea for treating wind-cold caused cough

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张杰等: "《中医痰证与方药》", 31 March 2016 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603975A (en) * 2021-01-13 2021-04-06 湘潭市中心医院 Traditional Chinese medicine granule for clearing lung heat and relieving cough, preparation method and application

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