CN106421357A - Medicine for treating recurrent oral ulceration and preparing method thereof - Google Patents
Medicine for treating recurrent oral ulceration and preparing method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a medicine for treating recurrent oral ulceration and a preparing method thereof. The medicine is mainly prepared from prepared rehmannia root, radix paeoniae alba, angelica sinensis, rhizoma anemarrhenae, moutan bark, sealwort, ligusticum chuanxiong, and phellodendron amurense rupr according to a certain weight ratio. The medicine has the functions of nourishing yin, replenishing blood, nourishing blood and harmonizing liver, clearing hear, cooling blood, dispelling pathogenic wind and removing dampness and promoting qi and reliving qi depression; meanwhile, the medicine has a quick result and good curative effect in treating the recurrent oral ulceration, and guarantees that the oral ulceration does not recurs again.
Description
Technical field
The present invention relates to a kind of treat medicine of recurrent oral ulceration and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Recurrent oral ulceration is a kind of disease of sickness rate highest in oral keritonocytes, common cold, dyspepsia,
Psychentonia, gloomy discomfort situations such as all can accidentally cause the generation of the disease, be apt to occur in lip, cheek, lingual margin etc., in any of mucosa
Position can all occur, but completely attached gingiva and hard palate are then rare in keratinization.The traditional Chinese medical science then thinks recurrent oral ulceration with taste
Accumulated heat, flaming up of heart-fire, stagnation of QI due to depression of the liver, insufficiency of the spleen tired wet, hyperactivity of fire caused by deficiency of YIN is relevant.Due to western medicine large side effects, therefore people couple
There is great demand in the Chinese medicine of effectively treatment recurrent oral ulceration, up to now, it has not been found that with regard to the present invention
Relevant report.
Content of the invention
The present inventor have found effectively treatment recurrence finally according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial
The medicine of property oral ulcer, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment recurrent oral ulceration.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is to select Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae to carry out
Prepared by combination, these drug regimens are caused each efficacy of drugs to produce synergism such that it is able to effectively treatment recurrent mouth
Chamber ulcer.Wherein, it is because that its nature and flavor is sweet from Radix Rehmanniae Preparata, tepor, enter liver and kidney channel, have YIN nourishing, the function of enriching blood, control the deficiency of YIN
Insufficiency of blood, waist knee flaccidity, Cough osteopyrexia, seminal emission, metrorrhagia, menoxenia, quench one's thirst, frequency of micturition, deaf, blurred vision.It is because from the Radix Paeoniae Alba
Its nature and flavor picric acid, cool, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in delaying, yin fluid astringing receives the function of antiperspirant, controls chest and abdomen pain over the hypochondriac region, rushes down
Dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Its nature and flavor sweet, acrid, warm is because from Radix Angelicae Sinensis, enter the heart,
Liver, spleen channel, have a benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturize laxation, control menoxenia, and amenorrhea is suffered from abdominal pain, and abdominal mass knot is poly-, metrorrhagia,
Headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome, dryness of the intestine is difficult just, weight, ulcer sores, incised wound, injury from falling down after bloody dysentery.Which is because from the Rhizoma Anemarrhenae
Nature and flavor hardship, trembles with fear, enters lung, stomach, kidney channel, have a nourishing YIN to lower pathogenic fire, and the function of moisturize laxation is controlled dysphoria with smothery sensation and quenched one's thirst, hectic fever due to YIN-deficiency consumptive fever, and lung-heat is coughed
Cough, constipation due to dry stool, dysuria.It is because that its nature and flavor is worked hard from Cortex Moutan, cool, enter the heart, liver and kidney channel, there is a heat clearing away, removing heat from blood,
And blood, the function of repercussive, the pathogenic heat attacking blood system in febrile diseases is controlled, speckle is sent out, shy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea, abdominal mass, carbuncle and ulcer, flutter damage.
It is because that its nature and flavor is sweet flat from Rhizoma Polygonati, enters spleen, lung, kidney channel have an invigorating the spleen and replenishing QI, embellish lung, the function of bone and muscle strengthening, governance wasting is trembled with fear
Heat, tuberculosis hemoptysis, body void lack of appetite after being ill, muscles and bones weakness, rheumatalgia, wind favus disease.It is because that its nature and flavor is pungent from Rhizoma Chuanxiong,
Temperature, enter liver, gallbladder meridian, there is an activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control that air-cooled headache rotation is dizzy, hypochondriac pain abdomen aches, arthralgia due to cold
Clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Its nature and flavor hardship is because from Cortex Phellodendri, trembles with fear, enter lung, stomach, kidney channel,
There is a nourishing YIN to lower pathogenic fire, the function of moisturize laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.From
Radix Glycyrrhizae is because that its nature and flavor is sweet flat, enters spleen, stomach, lung meridian, has and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, processs with controlling
Weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer,
Ulcer sores, solution poison of drug and alimentary toxicosis.
Specific embodiment
The drug dose of instant component is also that inventor is drawn through groping in a large number to summarize, and the consumption of each component is following heavy
All there is in the range of amount preferable curative effect：
15-25 gram of Radix Rehmanniae Preparata, 10-20 gram of the Radix Paeoniae Alba, 10-20 gram of Radix Angelicae Sinensis, 10-20 gram of the Rhizoma Anemarrhenae, 10-20 gram of Cortex Moutan, Rhizoma Polygonati 5-15
Gram, 4-8 gram of Rhizoma Chuanxiong, 4-8 gram of Cortex Phellodendri, 3-5 gram of Radix Glycyrrhizae.
Preferable amount is：
20 grams of Radix Rehmanniae Preparata, 15 grams of the Radix Paeoniae Alba, 15 grams of Radix Angelicae Sinensis, 15 grams of the Rhizoma Anemarrhenae, 15 grams of Cortex Moutan, 10 grams of Rhizoma Polygonati, 6 grams of Rhizoma Chuanxiong, Cortex Phellodendri 6
Gram, 3 grams of Radix Glycyrrhizae.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Radix Rehmanniae Preparata：Take crude drug, steam to surface corvinuses, take out, shine to eighty per cant dry when, section, dry；
2nd, the Radix Paeoniae Alba：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, moisten to inside and outside humidity uniformly, cut
Piece, dries；
3rd, Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening, slightly dry in the air, section is dried；
4th, the Rhizoma Anemarrhenae：Net impurity is picked, is hit with water and wash, pull out, soften, section is dried；
5th, Cortex Moutan：Impurity is picked, core is removed, clean, run through, section, dry；
6th, Rhizoma Polygonati：Clean soil, slightly moistens, section, dries；
7th, Rhizoma Chuanxiong：Impurity is picked, is separated large and small, be soaked in water, solarization is dried in the air, cut into slices after moistening, dry；
8th, Cortex Phellodendri：Impurity is picked, is washed, pull out, run through, cut into slices or shredding, dry；
9th, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant saturating when, pull out, run through, section, dry.
2nd, prepare
1st, the Radix Rehmanniae Preparata after processing, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae are put into decocting container
Interior, add water 6 times amount for the first time, after soaking 100 minutes, fries by intense fire to boil and rises, then with being cooked by slow fire 20 minutes, filters for the first time
Decoction liquor, first time decoction liquor is poured in container；
2nd, the medicinal residues of filtration are added 4 times amount, boils by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.
In prescription, Radix Rehmanniae Preparata has YIN nourishing, and the function of enriching blood is monarch drug；The Radix Paeoniae Alba is nourishing blood to suppress the hyperactive liver, pain relieving in delaying, and yin fluid astringing receives antiperspirant；
Cortex Moutan has heat clearing away, removing heat from blood, and blood, the function of repercussive, and the two is that ministerial drug, three taste medicines play YIN nourishing jointly, enrich blood, and blood-nourishing is soft
Liver, heat clearing away, removing heat from blood, the effect of the silt that disappears, treatment recurrent oral ulceration effect is comprehensive, and with YIN nourishing, enriches blood, nourishing blood to suppress the hyperactive liver, clearly
Heat, can effect a permanent cure based on removing heat from blood, and Rhizoma Chuanxiong has an activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is adjuvant drug, Radix Glycyrrhizae have and in delay
Anxious, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, for making medicine, is to take stopgap measures with remaining all medicines.
Medicine of the present invention has YIN nourishing, enriches blood, nourishing blood to suppress the hyperactive liver, heat clearing away, removing heat from blood, dispeiling pathogenic wind and removing dampness, the function of activating QI to alleviate the depression, uses
In treatment recurrent oral ulceration, short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Take rabbit 30, male and female dual-purpose, 2.0 2.5kg of body weight, points two groups, per group 15, one of which is overdose test
Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is that 10ml/kg, administering mode is given for administration by gavage
Medicine, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is no bad
Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept recurrent oral ulceration out-patient totally 17 for medical treatment.
2nd, diagnostic criteria
Classical symptom is lesion sensitivity, congested, raw aphtha, has an intense pain and with headache, heating, regional glandular enlargement
Deng.
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, 1 dose is each taken, early daily, evening respectively takes 1 time, is within 7 days a course for the treatment of, continuously takes
With 3 courses for the treatment of.
4th, efficacy assessment standard
Effective：Recurrent oral ulceration symptom disappears, and recovers normal, recovery from illness；
Take a turn for the better：Patient affected part hyperemia, has a headache and fever, and the phenomenon of regional glandular enlargement mitigates, and recurrent oral ulceration symptom is bright
Aobvious improvement, progressively recovers；
Invalid：Improvement standard person is not reached.
5th, therapeutic outcome（See the table below）
In above-mentioned treatment, with Drug therapy Blood of Patients with Recurrent Oral of the present invention 17, as a result effective 13, obvious effective rate is
76.47%, take a turn for the better 3, improvement rate is 17.64%, invalid 1, and total effective rate is 94.11%.
Claims (3)
1. a kind of medicine for treating recurrent oral ulceration, it is characterised in that：It is by the crude drug system in following weight range
Become：
15-25 gram of Radix Rehmanniae Preparata, 10-20 gram of the Radix Paeoniae Alba, 10-20 gram of Radix Angelicae Sinensis, 10-20 gram of the Rhizoma Anemarrhenae, 10-20 gram of Cortex Moutan, Rhizoma Polygonati 5-15
Gram, 4-8 gram of Rhizoma Chuanxiong, 4-8 gram of Cortex Phellodendri, 3-5 gram of Radix Glycyrrhizae.
2. medicine according to claim 1, the consumption of wherein each crude drug is：
20 grams of Radix Rehmanniae Preparata, 15 grams of the Radix Paeoniae Alba, 15 grams of Radix Angelicae Sinensis, 15 grams of the Rhizoma Anemarrhenae, 15 grams of Cortex Moutan, 10 grams of Rhizoma Polygonati, 6 grams of Rhizoma Chuanxiong, Cortex Phellodendri 6
Gram, 3 grams of Radix Glycyrrhizae.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Radix Rehmanniae Preparata：Take crude drug, steam to surface corvinuses, take out, shine to eighty per cant dry when, section, dry；
（2）The Radix Paeoniae Alba：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, moisten to inside and outside humidity uniformly,
Section, dries；
（3）Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening, slightly dry in the air, section is dried；
（4）The Rhizoma Anemarrhenae：Net impurity is picked, is hit with water and wash, pull out, soften, section is dried；
（5）Cortex Moutan：Impurity is picked, core is removed, clean, run through, section, dry；
（6）Rhizoma Polygonati：Clean soil, slightly moistens, section, dries；
（7）Rhizoma Chuanxiong：Impurity is picked, is separated large and small, be soaked in water, solarization is dried in the air, cut into slices after moistening, dry；
（8）Cortex Phellodendri：Impurity is picked, is washed, pull out, run through, cut into slices or shredding, dry；
（9）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant saturating when, pull out, run through, section, dry；
（Two）Prepare
（1）Radix Rehmanniae Preparata after processing, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae are put into decocting container
Interior, add water 6 times amount, after soaking 100 minutes, fries by intense fire to boil and rises, then with being cooked by slow fire 20 minutes, filters to decoct for the first time
Liquid, first time decoction liquor is poured in container；
（2）The medicinal residues of filtration are added water 4 times amount, is boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and takes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620408A (en) * | 2017-03-27 | 2017-05-10 | 李少伦 | Medicine for treating malignant hydatid form moles and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031357A (en) * | 2015-08-20 | 2015-11-11 | 王莉 | Medicine for treating oral ulcer and preparation method thereof |
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2016
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031357A (en) * | 2015-08-20 | 2015-11-11 | 王莉 | Medicine for treating oral ulcer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 徐俊霞主编: "《中华药浴全书——学用药浴不生病》", 31 October 2013, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620408A (en) * | 2017-03-27 | 2017-05-10 | 李少伦 | Medicine for treating malignant hydatid form moles and preparation method thereof |
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