CN104958626A - Medicine for treating colitis and preparation method thereof - Google Patents
Medicine for treating colitis and preparation method thereof Download PDFInfo
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- CN104958626A CN104958626A CN201510411143.6A CN201510411143A CN104958626A CN 104958626 A CN104958626 A CN 104958626A CN 201510411143 A CN201510411143 A CN 201510411143A CN 104958626 A CN104958626 A CN 104958626A
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Abstract
The invention discloses a medicine for treating colitis and a preparation method thereof. The medicine for treating colitis is prepared mainly by using smoked plum, atrina glass, golden thread, common aucklandia root, Chinese angelica, debark peony root, immature orange fruit, heterophylly falsestarwort root, largehead atractylodes rhizome, Indian bread and kudzuvine root according to certain weight proportions. The medicine disclosed by the invention has the efficacies of clearing heat and draining pus, tonifying spleen and excreting dampness, tonifying qi and checking diarrhea, and moisturizing pathogenic dryness to lubricate bowel, has a quick and good effect for treating colitis and can prevent the reoccurrence.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of colitis and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Colitis refers to that the colitis sexually transmitted disease (STD) that a variety of causes causes becomes.Pathological changes is confined to colorectal mucosa and Submucosa.Pathological changes multidigit, in sigmoid colon and rectum, also may extend to descending colon, even whole colon, and the course of disease is very long, normal recurrent exerbation.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating colitis in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment colitis, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment colitis.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Fructus Mume, Herba Patriniae, Rhizoma Coptidis, the Radix Aucklandiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Puerariae, Semen Coicis, Radix Glycyrrhizae to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat colitis.Fructus Mume is wherein selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.Herba Patriniae is selected to be that flat, enter liver, stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, controls acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies because its nature and flavor are bitter.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Select the Radix Aucklandiae to be that temperature, enters lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, the function of warming middle-JIAO for easing the stomach, control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain because its nature and flavor are worked hard, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, have dispelling the stagnated QI, loose painful abdominal mass, rush down expectorant, the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria, edema distension, phlegm retention cough with dyspnea, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Radix Puerariae to be that flat, enter spleen, stomach warp, have yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is only drunk, cure the wound cold, cure the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery because its nature and flavor are sweet pungent, skin eruption is not saturating, hypertension, and angina pectoris is deaf.Semen Coicis is selected to be because its nature and flavor are sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis, verruca plana.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, for controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Fructus Mume 13-16 gram, Herba Patriniae 10-14 gram, Rhizoma Coptidis 3-6 gram, Radix Aucklandiae 7-10 gram, Radix Angelicae Sinensis 8-12 gram, Radix Paeoniae Alba 10-14 gram, Fructus Aurantii Immaturus 8-12 gram, Radix Pseudostellariae 11-13 gram, Rhizoma Atractylodis Macrocephalae 9-11 gram, Poria 13-17 gram, Radix Puerariae 10-15 gram, Semen Coicis 7-12 gram, Radix Glycyrrhizae 4-8 gram.
Be preferably:
Fructus Mume 15 grams, Herba Patriniae 12 grams, Rhizoma Coptidis 5 grams, the Radix Aucklandiae 9 grams, Radix Angelicae Sinensis 10 grams, the Radix Paeoniae Alba 12 grams, Fructus Aurantii Immaturus 10 grams, Radix Pseudostellariae 12 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, 15 grams, Poria, Radix Puerariae 12 grams, Semen Coicis 10 grams, 6 grams, Radix Glycyrrhizae.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;
2, Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;
3, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
4, the Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
5, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
6, the Radix Paeoniae Alba: get Radix Paeoniae Alba sheet Testa Tritici and fry to micro-Huang, slightly focal spot with slow fire, sieve removes Testa Tritici, dries in the air cool;
7, Fructus Aurantii Immaturus: first wheat bran is removed even in the pot of heating, when marquis's cigarette is emerged, add Fructus Aurantii Immaturus sheet, stir to micro-in coke yellow, take out, sieve removes wheat bran, and cool, every Fructus Aurantii Immaturus sheet 50kg, uses wheat bran 5kg;
8, Radix Pseudostellariae: extract fibrous root, dry;
9, the Rhizoma Atractylodis Macrocephalae: wheat bran is sprinkled in hot pot, adds Rhizoma Atractylodis Macrocephalae sheet in time smoldering, fry to coke yellow, effusion burnt odor gas, take out, sieve removes wheat bran, and every 100kg Rhizoma Atractylodis Macrocephalae sheet, uses wheat bran 10kg;
10, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
11, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
12, Semen Coicis: get crude drug, removing residual cot, impurity;
13, Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin.
Two, prepare
1, the Fructus Mume of described weight, Herba Patriniae, Rhizoma Coptidis, the Radix Aucklandiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Puerariae, Semen Coicis, Radix Glycyrrhizae are put into decocting container, add water 6 times amount for the first time, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring, 2 doses are divided into take.
In prescription, Herba Patriniae has heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, is monarch drug; Semen Coicis spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus; Radix Angelicae Sinensis has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes the function of laxation, and the two is ministerial drug, three taste medicines play heat clearing away jointly, and blood, laxation, removing toxic substances, evacuation of pus, eliminating dampness by diuresis, spleen invigorating, the effect of antidiarrheal, treatment colitis effect is comprehensive, and with clearing away heat and discharging pus, spleen invigorating eliminating dampness by diuresis, moisturizing laxation is that master can be effected a permanent cure, Poria has eliminating dampness and diuresis, strengthening the spleen stomach function regulating, and the function of mind tranquilizing and the heart calming is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, for making medicine, is take stopgap measures with all medicines of remainder.
Medicine of the present invention has clearing away heat and discharging pus, spleen invigorating eliminating dampness by diuresis, and QI invigorating antidiarrheal is moisturized the function of laxation, is used for the treatment of colitis, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept colitis out-patient totally 30 examples for medical treatment.
2, diagnostic criteria
Classical symptom is diarrhoea, stomachache, mucus just and bloody purulent stool, tenesmus, very then constipation, stool in a few days, can not be led to, often weak with becoming thin.Patient often shows and loses weight and pale complexion, and in the disease activity phase, during abdomen examination, colon site often has tenderness; Stomachache companion tenesmus, continues or diarrhoea, row's mucus bloody purulent stool of recurrent exerbation, the lighter every day 3 ~ 4 times, and tens of times of severe one or diarrhoea and constipation alternately occur.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: colitis symptoms disappears, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient's stomachache, diarrhoea phenomenon alleviate, and colitis symptoms is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy colitis disease 30 example of the present invention, effective 22 examples of result, obvious effective rate is 73.33%, and take a turn for the better 6 examples, and improvement rate is 20%, and invalid 2 examples, total effective rate is 93.33%.
Claims (3)
1. treat a medicine for colitis, it is characterized in that: it is made up of the crude drug in following weight range:
Fructus Mume 13-16 gram, Herba Patriniae 10-14 gram, Rhizoma Coptidis 3-6 gram, Radix Aucklandiae 7-10 gram, Radix Angelicae Sinensis 8-12 gram, Radix Paeoniae Alba 10-14 gram, Fructus Aurantii Immaturus 8-12 gram, Radix Pseudostellariae 11-13 gram, Rhizoma Atractylodis Macrocephalae 9-11 gram, Poria 13-17 gram, Radix Puerariae 10-15 gram, Semen Coicis 7-12 gram, Radix Glycyrrhizae 4-8 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Fructus Mume 15 grams, Herba Patriniae 12 grams, Rhizoma Coptidis 5 grams, the Radix Aucklandiae 9 grams, Radix Angelicae Sinensis 10 grams, the Radix Paeoniae Alba 12 grams, Fructus Aurantii Immaturus 10 grams, Radix Pseudostellariae 12 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, 15 grams, Poria, Radix Puerariae 12 grams, Semen Coicis 10 grams, 6 grams, Radix Glycyrrhizae.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;
(2) Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;
(3) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
(4) Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
(5) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
(6) Radix Paeoniae Alba: get Radix Paeoniae Alba sheet bran and fry to micro-Huang, slightly focal spot with slow fire, sieve removes Testa Tritici, dries in the air cool;
(7) Fructus Aurantii Immaturus: Fructus Aurantii Immaturus: first wheat bran is removed even in the pot of heating, when marquis's cigarette is emerged, add Fructus Aurantii Immaturus sheet, stir to micro-in coke yellow, take out, sieve removes wheat bran, and cool, every Fructus Aurantii Immaturus sheet 50kg, uses wheat bran 5kg;
(8) Radix Pseudostellariae: extract fibrous root, dry;
(9) Rhizoma Atractylodis Macrocephalae: wheat bran is sprinkled in hot pot, adds Rhizoma Atractylodis Macrocephalae sheet in time smoldering, fry to coke yellow, effusion burnt odor gas, take out, sieve removes wheat bran, and every 100kg Rhizoma Atractylodis Macrocephalae sheet, uses wheat bran 10kg;
(10) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(11) Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
(12) Semen Coicis: get crude drug, removing residual cot, impurity;
(13) Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;
(2) prepare
(1) Fructus Mume of described weight, Herba Patriniae, Rhizoma Coptidis, the Radix Aucklandiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Puerariae, Semen Coicis, Radix Glycyrrhizae are put into decocting container, add water 6 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring, 2 doses are divided into take.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343462A (en) * | 2015-12-18 | 2016-02-24 | 张朝兰 | Medicine for treating osteomyelitis and preparation method of medicine |
| CN107714597A (en) * | 2017-09-26 | 2018-02-23 | 孟庆云 | A kind of skin whitening, moisturizing Essence and preparation method thereof |
| CN110833586A (en) * | 2018-08-16 | 2020-02-25 | 中国中医科学院望京医院 | A Chinese medicinal composition for treating colitis |
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| US20070160689A1 (en) * | 2006-01-12 | 2007-07-12 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| CN104367667A (en) * | 2013-08-14 | 2015-02-25 | 方戈 | Traditional Chinese medicine composition for treating chronic diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070160689A1 (en) * | 2006-01-12 | 2007-07-12 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| CN104367667A (en) * | 2013-08-14 | 2015-02-25 | 方戈 | Traditional Chinese medicine composition for treating chronic diarrhea |
Non-Patent Citations (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343462A (en) * | 2015-12-18 | 2016-02-24 | 张朝兰 | Medicine for treating osteomyelitis and preparation method of medicine |
| CN107714597A (en) * | 2017-09-26 | 2018-02-23 | 孟庆云 | A kind of skin whitening, moisturizing Essence and preparation method thereof |
| CN110833586A (en) * | 2018-08-16 | 2020-02-25 | 中国中医科学院望京医院 | A Chinese medicinal composition for treating colitis |
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Application publication date: 20151007 |