CN105012669A - Medicine for treating upper gastrointestinal hemorrhage and preparation method of medicine - Google Patents
Medicine for treating upper gastrointestinal hemorrhage and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses medicine for treating upper gastrointestinal hemorrhage and a preparation method of the medicine. The medicine is mainly prepared by radix astragali, radix pseudostellariae, bighead atractylodes rhizome, liquorice, angelica sinensis, white peony root, donkey-hide glue, sanguisorba officinalis, cacumen biotae, hairyvein agrimony, red peony root, poria cocos and radix ophiopogonis according to certain weight proportion. The medicine has functions of invigorating spleen and nourishing qi, nourishing the blood and stopping bleeding, relieving swelling and promoting granulation, harmonizing middle-jiao and relieving pain and tonifying stomach and promoting fluid and is fast to become effective, good in curative effect and capable of avoiding relapse during upper gastrointestinal hemorrhage treating.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of upper gastrointestinal hemorrhage and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Upper gastrointestinal hemorrhage refers to the digestive tract of more than Qu Shi ligament, and what comprise that the pathological changes such as esophagus, Stomach duodenum or pancreas gallbladder cause is hemorrhage, and the jejunum Lesion Hemorrhage after gastrojejunostomy also belongs to this scope; This disease belongs to the mass formed by blood stasis scope of the traditional Chinese medical science.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating upper gastrointestinal hemorrhage in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment upper gastrointestinal hemorrhage, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment upper gastrointestinal hemorrhage.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects the Radix Astragali, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Colla Corii Asini, Radix Sanguisorbae, Cacumen Platycladi, Herba Agrimoniae, Radix Paeoniae Rubra, Poria, Radix Ophiopogonis, Concha Ostreae, Os Draconis medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat upper gastrointestinal hemorrhage.Wherein, select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, and overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Colla Corii Asini to be that flat, enter lung, liver, kidney channel, have nourishing YIN and supplementing blood, antiabortive function, controls blood deficiency, cough due to consumptive disease because its nature and flavor are sweet, haematemesis, epistaxis, to have blood in stool, menoxenia, metrorrhagia, vaginal bleeding during pregnancy.Radix Sanguisorbae is selected to be because of its nature and flavor picric acid, to tremble with fear.Enter liver, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, collapse, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.Select Cacumen Platycladi to be because its nature and flavor are pained, cold, enter the heart, liver, large intestine channel, have removing heat from blood, hemostasis, wind-damp dispelling, the function of loose toxic swelling, controls haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, and mumps is scalded.Select Herba Agrimoniae to be because its nature and flavor toil, flat, enter lung, liver, spleen channel, have hemostasis, the function of stomach invigorating, controls spitting of blood, and spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduce phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Os Draconis are selected to be because its property sweet-puckery flavor, flat, enter the heart, liver, kidney, large intestine channel, there is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the function of promoting tissue regeneration and ulcer healing, Zhi Jing Epilepsy is demented, and palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, seminal emission stranguria with turbid discharge, tell nosebleed to have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Radix Astragali 10-20 gram, Radix Pseudostellariae 11-15 gram, Rhizoma Atractylodis Macrocephalae 5-9 gram, Radix Glycyrrhizae 4-8 gram, Radix Angelicae Sinensis 5-10 gram, Radix Paeoniae Alba 10-15 gram, Colla Corii Asini 9-15 gram, Radix Sanguisorbae 11-15 gram, Cacumen Platycladi 9-15 gram, Herba Agrimoniae 15-25 gram, Radix Paeoniae Rubra 8-12 gram, Poria 11-15 gram, Radix Ophiopogonis 8-12 gram, Concha Ostreae 13-16 gram, Os Draconis 14-17 gram.
Be preferably:
The Radix Astragali 15 grams, Radix Pseudostellariae 12 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, 6 grams, Radix Glycyrrhizae, Radix Angelicae Sinensis 6 grams, the Radix Paeoniae Alba 12 grams, 12 grams, Colla Corii Asini, Radix Sanguisorbae 12 grams, Cacumen Platycladi 12 grams, Herba Agrimoniae 20 grams, Radix Paeoniae Rubra 10 grams, 12 grams, Poria, Radix Ophiopogonis 10 grams, Concha Ostreae 15 grams, Os Draconis 15 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
2, Radix Pseudostellariae: extract fibrous root, dry;
3, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
4, Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;
5, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
6, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
7, Colla Corii Asini: smash use to pieces;
8, Radix Sanguisorbae: get pure land elm sheet, put in pot, fries to surface black, inner strong yellow, spray clear water, and taking-up is dried;
9, Cacumen Platycladi: get clean Cacumen Platycladi and put in pot, fry with high heat to surperficial pitchy, spray clear water, taking-up is dried;
10, Herba Agrimoniae: removing impurity undesirable root, cleans and runs through, cut off, dry;
11, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
12, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
13, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
14, Concha Ostreae: by the Concha Ostreae cleaned, put on smokeless stove fire and be calcined to canescence, taking-up cools, and pulverizes;
15, Os Draconis: the Os Draconis getting outwash, forge and are popular on smokeless stove fire or in crucible, take out, cool, pulverize.
Two, prepare
1, the Radix Astragali of described weight, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Colla Corii Asini, Radix Sanguisorbae, Cacumen Platycladi, Herba Agrimoniae, Radix Paeoniae Rubra, Poria, Radix Ophiopogonis, Concha Ostreae, Os Draconis are put into decocting container to add water 6 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring, 2 doses are divided into take.
In prescription, Os Draconis have tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, and the function of promoting tissue regeneration and ulcer healing is monarch drug; Cacumen Platycladi removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling; Herba Agrimoniae has hemostasis, the function of stomach invigorating, and the two is ministerial drug, and three taste medicines play removing heat from blood jointly, hemostasis, promoting tissue regeneration and ulcer healing, stomach invigorating, the effect of calming the nerves, treatment upper gastrointestinal hemorrhage effect is comprehensive, and with stomach invigorating, granulation promoting, hemostasis, sore is that master can be effected a permanent cure, and the Radix Astragali is useful defends consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the function of granulation promoting is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription is for making medicine, and all medicines take stopgap measures with being left.
Medicine of the present invention has invigorating the spleen and benefiting QI, nourishing blood and hemoslasis, detumescence and promoting granulation, and pain relieving in slow, reinforcing stomach reg fluid function, is used for the treatment of upper gastrointestinal hemorrhage, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept upper gastrointestinal hemorrhage out-patient totally 35 examples for medical treatment.
2, diagnostic criteria
Hematemesis and (or) melena are the characteristic performances of upper gastrointestinal hemorrhage.Often there are hematemesis and melena in bleeding part the above person of pylorus, and below pylorus, person only can show as melena.But the above pathological changes of the few and slow-footed pylorus of amount of bleeding can rarely seen melena, and the pathological changes below large, the fireballing pylorus of amount of bleeding can flow into stomach because of blood reflux, causes hematemesis.Patient often shows anemia or Progressive symmetric erythrokeratodermia anemia, dizziness, weakness, stand up suddenly can produce faint, thirsty, limbs creeping chill and blood pressure on the low side etc.Bleed profusely and reach whole body blood volume 30% ~ 50% and can produce shock, show as dysphoria or obnubilation, pale complexion, the limbs being moist and cold, lip cyanosis, dyspnea, blood pressure drops to not detecting, pulse pressure difference reduce and pulse fast and weak etc., if deal with improperly, death can be caused.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 12 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: upper gastrointestinal hemorrhage transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient is dizzy, hematemesis phenomenon alleviates, and upper gastrointestinal hemorrhage symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy Patients with Upper Gastrointestinal Hemorrhage 35 example of the present invention, effective 29 examples of result, obvious effective rate is 82.86%, and take a turn for the better 4 examples, and improvement rate is 11.43%, and invalid 2 examples, total effective rate is 94.29%.
Claims (3)
1. treat a medicine for upper gastrointestinal hemorrhage, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Astragali 10-20 gram, Radix Pseudostellariae 11-15 gram, Rhizoma Atractylodis Macrocephalae 5-9 gram, Radix Glycyrrhizae 4-8 gram, Radix Angelicae Sinensis 5-10 gram, Radix Paeoniae Alba 10-15 gram, Colla Corii Asini 9-15 gram, Radix Sanguisorbae 11-15 gram, Cacumen Platycladi 9-15 gram, Herba Agrimoniae 15-25 gram, Radix Paeoniae Rubra 8-12 gram, Poria 11-15 gram, Radix Ophiopogonis 8-12 gram, Concha Ostreae 13-16 gram, Os Draconis 14-17 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
The Radix Astragali 15 grams, Radix Pseudostellariae 12 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, 6 grams, Radix Glycyrrhizae, Radix Angelicae Sinensis 6 grams, the Radix Paeoniae Alba 12 grams, 12 grams, Colla Corii Asini, Radix Sanguisorbae 12 grams, Cacumen Platycladi 12 grams, Herba Agrimoniae 20 grams, Radix Paeoniae Rubra 10 grams, 12 grams, Poria, Radix Ophiopogonis 10 grams, Concha Ostreae 15 grams, Os Draconis 15 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(2) Radix Pseudostellariae: extract fibrous root, dry;
(3) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(4) Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;
(5) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
(6) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(7) Colla Corii Asini: smash use to pieces;
(8) Radix Sanguisorbae: get pure land elm sheet, put in pot, fries to surface black, inner strong yellow, spray clear water, and taking-up is dried;
(9) Cacumen Platycladi: get clean Cacumen Platycladi and put in pot, fry with high heat to surperficial pitchy, spray clear water, taking-up is dried;
(10) Herba Agrimoniae: removing impurity undesirable root, runs through, cut off, dry;
(11) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
(12) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(13) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
(14) Concha Ostreae: by the Concha Ostreae cleaned, put on smokeless stove fire and be calcined to canescence, taking-up cools, and pulverizes;
(15) Os Draconis: the Os Draconis getting outwash, forge and are popular on smokeless stove fire or in crucible, take out, cool, pulverize;
(2) prepare
(1) Radix Astragali of described weight, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Colla Corii Asini, Radix Sanguisorbae, Cacumen Platycladi, Herba Agrimoniae, Radix Paeoniae Rubra, Poria, Radix Ophiopogonis, Concha Ostreae, Os Draconis are put into decocting container to add water 6 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring, 2 doses are divided into take.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108686192A (en) * | 2018-08-13 | 2018-10-23 | 张晓玲 | A kind of Chinese medicine composition for treating recurrent upper gastrointestinal bleeding |
| RU2681851C1 (en) * | 2018-05-04 | 2019-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Anti-burn means |
| CN110934953A (en) * | 2019-12-05 | 2020-03-31 | 青岛大学附属医院 | Preparation method of radix pseudostellariae tonic soup for nasopharynx cancer radiotherapy adverse reaction conditioning |
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| CN102552694A (en) * | 2012-02-15 | 2012-07-11 | 西南交通大学 | Medicinal preparation for treating upper gastrointestinal hemorrhage and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2681851C1 (en) * | 2018-05-04 | 2019-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Anti-burn means |
| CN108686192A (en) * | 2018-08-13 | 2018-10-23 | 张晓玲 | A kind of Chinese medicine composition for treating recurrent upper gastrointestinal bleeding |
| CN110934953A (en) * | 2019-12-05 | 2020-03-31 | 青岛大学附属医院 | Preparation method of radix pseudostellariae tonic soup for nasopharynx cancer radiotherapy adverse reaction conditioning |
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Application publication date: 20151104 |