CN103263642B - Medicine for treating irregular menstrual period and preparation method thereof - Google Patents
Medicine for treating irregular menstrual period and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating the irregular menstrual period and a preparation method thereof. The medicine is prepared from angelica sinensis, cinnamon, rhizoma cyperi, turmeric, red flower, hematoxylon, sunflower, codonopsis pilosula and moutan bark according to a certain weight proportion. The medicine has the effects of nourishing yin, clearing the heat, promoting qi to activate blood, dissipating blood stasis to stop pain, tonifying kidneys, stopping bleeding and adjusting the menstrual period, has a quick response of treating the irregular menstrual period and is short in treatment period.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of irregular menstrual period and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Irregular menstrual period, also known as delay of menstrual cycle, menoxenia is a kind of common gynaecopathia.Show as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.Hematopathy, hypertension, hepatopathy, endocrinopathy, miscarriage, ectopic pregnancy, hydatidiform mole, reproductive tract infection, tumor (as ovarian tumor, hysteromyoma) etc. all can cause menoxenia.Menoxenia shows as the disorder of menstrual cycle or amount of bleeding, has following several situation: Irregular uterine bleeding, menorrhagia or the persistent period long.Dysfunctional uterine hemorrhage, refers to that interior external genitalia is without significant organic pathological changes, and the metrorrhagia caused by endocrine regulation unbalance of system.Menoxenia has had a strong impact on daily life and the work of women, and endangers the healthy of women.At present, because Western medicine effectively cannot treat menoxenia, and certain side effect is had.
Summary of the invention:
Therefore there is great demand in the Chinese medicine of people to special effect.The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment irregular menstrual period, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine for the treatment of irregular menstrual period.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat menoxenia.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Rhizoma Cyperi is selected to be because the pungent micro-hard work of its nature and flavor, flat, enter liver, tri-jiao channel, resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Rhizoma Curcumae Longae to be that temperature, enters spleen, Liver Channel, have removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, the function of pain relieving, control trusted subordinate's feeling of fullness distending pain, brachialgia ， mass in the abdomen, women's blood stasis amenorrhea because its nature and flavor are worked hard, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Lignum Sappan to be because its nature and flavor are sweet, salty, flat, have promoting the circulation of blood, removing blood stasis with potent drugs, detumescence, the function of pain relieving, controls married woman's vim and vigour cardiac and abdominal pain, amenorrhea, postnatal blood stasis, distending pain dyspnea with rapid respiration, dysentery, tetanus.Medulla Tetrapanacis is selected to be that cool, have eliminating the pathogens from the lung, diuresis, the function of lower milk, controls dysuria, gonorrhea, edema, puerpera's galactostasis because its property slightly sweet flavor.Select Herba Leonuri to be that cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia because its nature and flavor are worked hard, control and Lou have difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select sunflower, different name Flos Helianthi, it is sweet in flavor and warm in property, nontoxic, dispels the wind, and the function of improving eyesight, controls headache, blurred vision, swelling of the face, can expedite the emergence of again.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Select Colla Corii Asini to be that flat, enter lung, liver, kidney channel, have nourishing YIN and supplementing blood, antiabortive function, controls blood deficiency, cough due to consumptive disease because its nature and flavor are sweet, haematemesis, epistaxis, to have blood in stool, menoxenia, metrorrhagia, vaginal bleeding during pregnancy.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Angelicae Sinensis 15-25 gram of Rhizoma Chuanxiong 10-20 gram of Radix Rehmanniae Preparata 15-25 gram
Radix Paeoniae Alba 8-15 gram of Cortex Cinnamomi 8-15 gram of Rhizoma Cyperi 10-20 gram
Rhizoma Curcumae Longae 10-20 gram of Flos Carthami 8-15 gram of Lignum Sappan 8-15 gram
Medulla Tetrapanacis 8-15 gram of Herba Leonuri 15-25 gram of Radix Glycyrrhizae 8-15 gram
Sunflower 10-20 gram of Radix Codonopsis 10-15 gram of Colla Corii Asini 8-12 gram
Cortex Moutan 8-12 gram of Radix Bupleuri 10-15 gram
Wherein, be preferably
Radix Angelicae Sinensis 20 grams of Rhizoma Chuanxiongs 15 grams of Radix Rehmanniae Preparata 20 grams
The Radix Paeoniae Alba 10 grams of Cortex Cinnamomis 10 grams of Rhizoma Cyperis 15 grams
Rhizoma Curcumae Longae 15 grams of Flos Carthamis 10 grams of Lignum Sappans 10 grams
10 grams, Medulla Tetrapanacis 10 grams of Herba Leonuris 20 grams of Radix Glycyrrhizaes
10 grams, sunflower 15 grams of Radix Codonopsis 12 grams of Colla Corii Asini
Cortex Moutan 10 grams of Radix Bupleuri 12 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Angelicae Sinensis: pick roguing and sanction, clean, moistening, slightly dry in the air when being suitable for inside and outside humidity, section is dried;
2, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
3, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
4, the Radix Paeoniae Alba: pick roguing and sanction, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
5, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;
6, Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;
7, Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;
8, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
9, Lignum Sappan: get crude drug, is sawn into short section, then is split into fragment or pound sheet;
10, Medulla Tetrapanacis: get crude drug, removing impurity, section;
11, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;
12, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
13, sunflower: pick clean impurity, dry;
14, Radix Codonopsis: clean silt, run through reed, section, dries;
15, Colla Corii Asini: smash use to pieces;
16, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
17, Radix Bupleuri: pick decontamination, cleans silt, pulls out, run through rear section, dry.
Two, prepare
1, the Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri are decocted with water, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, obtain first time decoction liquor.
2, add water medicinal residues after first time filtration 3 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling.
3, by twice decoction liquor mixing, then simmer in water 15 minutes, medicinal liquid is divided into 2 doses.
Medicine of the present invention has nourishing YIN and clearing away heat, promoting flow of QI and blood, scattered silt pain relieving, reinforcing the kidney and arresting hemorrhage, regulates effect of menstrual cycle, and treatment irregular menstrual period instant effect, short treating period, cure rate is high.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test and the clinical observation test of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 10, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 150 example for medical treatment, 20-30 years old 40 age example, 30-40 years old 70 example, 40-50 years old 40 example.
2, diagnostic criteria
Menoxenia shows as the disorder of menstrual cycle or amount of bleeding, has following several situation:
Irregular uterine bleeding.Comprise: menorrhagia or the persistent period long.Be common in hysteromyoma, endometrial polyp, endometrial hyperplasia, endometriosis etc.; Hypomenorrhea, through amount and menstrual period all few; Polymenorrhea and menstruation interval are less than 25 days; Menstrual cycle prolongation and menstruation interval are longer than 35 days; Irregular bleeding, can be caused by a variety of causes, hemorrhage irregular.Several situation can be caused by local cause, endocrine reason or systemic disease above.
Dysfunctional uterine hemorrhage.In referring to, external genitalia is without significant organic pathological changes, and the metrorrhagia caused by endocrine regulation unbalance of system.Be modal one in menoxenia, be common in adolescence and climacteric.Be divided into ovulatory and anovulatory two class, about 85% case belongs to anovulatory function.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 20 days, is a course for the treatment of, takes two courses for the treatment of continuously.
4, efficacy assessment standard
Effective: clinical symptom disappearance after treatment, menstrual cycle recovers normal, observes half a year without recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and menstrual cycle progressively recovers normal;
Invalid: clinical part transference cure or without change, do not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy irregular menstrual period patient 150 example of the present invention, effective 144 examples of result, obvious effective rate is 96%, and take a turn for the better 4 examples, and improvement rate is 2.67%, and invalid 2 examples, total effective rate is 98.67%.
Claims (3)
1. treat a medicine for irregular menstrual period, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Angelicae Sinensis 15-25 gram of Rhizoma Chuanxiong 10-20 gram of Radix Rehmanniae Preparata 15-25 gram
Radix Paeoniae Alba 8-15 gram of Cortex Cinnamomi 8-15 gram of Rhizoma Cyperi 10-20 gram
Rhizoma Curcumae Longae 10-20 gram of Flos Carthami 8-15 gram of Lignum Sappan 8-15 gram
Medulla Tetrapanacis 8-15 gram of Herba Leonuri 15-25 gram of Radix Glycyrrhizae 8-15 gram
Sunflower 10-20 gram of Radix Codonopsis 10-15 gram of Colla Corii Asini 8-12 gram
Cortex Moutan 8-12 gram of Radix Bupleuri 10-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Angelicae Sinensis 20 grams of Rhizoma Chuanxiongs 15 grams of Radix Rehmanniae Preparata 20 grams
The Radix Paeoniae Alba 10 grams of Cortex Cinnamomis 10 grams of Rhizoma Cyperis 15 grams
Rhizoma Curcumae Longae 15 grams of Flos Carthamis 10 grams of Lignum Sappans 10 grams
10 grams, Medulla Tetrapanacis 10 grams of Herba Leonuris 20 grams of Radix Glycyrrhizaes
10 grams, sunflower 15 grams of Radix Codonopsis 12 grams of Colla Corii Asini
Cortex Moutan 10 grams of Radix Bupleuri 12 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(2) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(3) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
(4) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(5) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or infiltrate a moment by warm water, section, dries;
(6) Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;
(7) Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;
(8) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(9) Lignum Sappan: get crude drug, is sawn into short section, then is split into fragment or pound sheet;
(10) Medulla Tetrapanacis: get crude drug, removing impurity, section;
(11) Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;
(12) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(13) sunflower: pick clean impurity, dry;
(14) Radix Codonopsis: clean silt, run through reed, section, dries;
(15) Colla Corii Asini: smash use to pieces;
(16) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
(17) Radix Bupleuri: pick decontamination, cleans silt, pulls out, run through rear section, dry;
(2) prepare
(1) Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri are decocted with water, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, obtain first time decoction liquor;
(2) add water medicinal residues after first time filtration 3 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling;
(3) by twice decoction liquor mixing, then simmer in water 15 minutes, medicinal liquid is divided into 2 doses.
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| CN103520673B (en) * | 2013-10-12 | 2015-05-27 | 神艳 | Traditional Chinese medicine for treating deficiency of Qi and blood syndrome type of menopathy |
| CN103536887B (en) * | 2013-10-30 | 2015-05-13 | 贾贵玲 | Traditional Chinese medicament for treating hypomenorrhea with symptoms of blood stasis and channel blockage |
| CN105288011A (en) * | 2015-10-29 | 2016-02-03 | 丁芬 | Traditional Chinese medicine composition for treating irregular menstruation and pelvic inflammation |
| CN106377669A (en) * | 2016-12-08 | 2017-02-08 | 张云侠 | Medicament for treating female amenorrhea and preparation method of medicament |
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| CN1440776A (en) * | 2003-04-09 | 2003-09-10 | 江西汇仁药业有限公司 | Chinese medicine for regulating menstruation and nourishing blood |
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| 姚五达治疗月经病的特点;于丽军;《北京中医杂志》;19941231(第2期);3-4 * |
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