CN103432390B - Medicament for treating coronary heart disease and preparation method thereof - Google Patents

Medicament for treating coronary heart disease and preparation method thereof Download PDF

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CN103432390B
CN103432390B CN201310387322.1A CN201310387322A CN103432390B CN 103432390 B CN103432390 B CN 103432390B CN 201310387322 A CN201310387322 A CN 201310387322A CN 103432390 B CN103432390 B CN 103432390B
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董中影
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Abstract

The invention discloses a medicament for treating coronary heart disease and a preparation method thereof. The medicament is mainly prepared from astragalus root, prepared rehmannia root, radix polygonati officinalis, radix codonopsitis, tuckahoe, Chinese yam, ligusticum wallichii, radix bupleuri, costus root and other drugs according to certain weight ratios. The medicament has functions of activating blood circulation to stimulate meridians, calming the mind and nerves and tonifying middle-jiao and qi, and is used for treating coronary heart disease which can not relapse after cure.

Description

A kind of medicine for the treatment of coronary heart disease and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Coronary heart disease is called for short coronary heart disease.Refer to that, because lipid metabolism is abnormal, the lipid in blood is calm on the endarterium of otherwise smooth, pile up at the lipid material of some similar medicated porridge samples of endarterium and form white speckle, be called atherosclerotic lesion.These specklees gradually increase and cause lumen of artery narrow, blood flow is obstructed, causes heart ischemia, produce angina pectoris.At present, western medicine coronary heart disease poor effect, and have more side effect, therefore, there is very large demand to the Chinese medicine of rapid, effective treatment coronary heart disease in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment coronary heart disease, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating coronary heart disease.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Pericarpium Citri Reticulatae, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat coronary disease palindromia.Pericarpium Citri Reticulatae is wherein selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Rhizoma Polygonati Odorati to be that flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst because its nature and flavor are sweet, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforce the kidney, the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select the Radix Aucklandiae to be that temperature, enters lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, the function of warming middle-JIAO for easing the stomach, control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain because its nature and flavor are worked hard, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea , Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea , mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina cordis, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia , mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Adenophorae to be that cool, enter lung, Liver Channel, have nourishing YIN and clearing away lung-heat, the function of expelling phlegm for arresting cough, controls lung-heat type cough, chronic consumptive disease chronic cough because its property sweet and slightly bitter taste, the moon hinders dry pharynx laryngalgia.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Pericarpium Citri Reticulatae 8-15 gram of Radix Astragali 8-15 gram of Radix Rehmanniae Preparata 8-15 gram
Rhizoma Polygonati Odorati 8-15 gram of Radix Codonopsis 8-15 gram of Poria 8-15 gram
Rhizoma Dioscoreae 10-20 gram of Rhizoma Chuanxiong 15-25 gram of Radix Bupleuri 10-20 gram
Radix Aucklandiae 8-15 gram of Radix Rehmanniae 8-12 gram of Radix Paeoniae Rubra 8-12 gram
Fructus Aurantii 10-20 gram of Flos Carthami 10-20 gram of Radix Salviae Miltiorrhizae 8-12 gram
Radix Angelicae Sinensis 15-25 gram of Radix Adenophorae 8-15 gram of Semen Persicae 8-15 gram
Radix Ophiopogonis 8-15 gram of Ramulus Cinnamomi 15-25 gram Fructus Schisandrae Chinensis 10-20 gram
Preferable amount is
Pericarpium Citri Reticulatae 10 grams of Radixs Astragali 10 grams of Radix Rehmanniae Preparata 10 grams
10 grams, Rhizoma Polygonati Odorati 10 grams of Radix Codonopsis 10 grams of Poria
Rhizoma Dioscoreae 15 grams of Rhizoma Chuanxiongs 20 grams of Radix Bupleuri 15 grams
The Radix Aucklandiae 10 grams of Radix Rehmanniae 9 grams of Radix Paeoniae Rubra 9 grams
Fructus Aurantii 15 grams of Flos Carthamis 15 grams of Radix Salviae Miltiorrhizaes 9 grams
10 grams, Radix Angelicae Sinensis 20 grams of Radix Adenophoraes 10 grams of Semen Persicaes
10 grams of Ramulus Cinnamomi Radix Ophiopogonis, 20 grams of Fructus Schisandrae Chinensis 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
2, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water;
3, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
4, Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
5, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
6, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
7, Rhizoma Dioscoreae: pick clean impurity, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, pull out and slightly dry in the air, section is dried or is dried;
8, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
9, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
10, the Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
11, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
12, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
13, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
14, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
15, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
16, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
17, Radix Adenophorae: pick clean impurity, go reed, wash, slightly profit, section, well sifted dries;
18, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
19, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
20, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
21, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.
Two, prepare
1, the Pericarpium Citri Reticulatae of described weight, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine are decocted with water secondary, first time adds 6 times of water gagings and soaks, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 3 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 6 doses to take decoction medicinal liquid.
Medicine of the present invention has promoting blood circulation to restore menstrual flow, calming heart and tranquilizing mind, and effect of invigorating the spleen and replenishing QI, is used for the treatment of coronary heart disease, short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.2kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy coronary heart disease of the present invention
1, physical data
Accept out-patient's totally 150 examples for medical treatment, its male patient 90 example, female patient 60 example.
2, diagnostic criteria
Coronary heart disease clinical manifestation
Clinically be divided into conceal type, angina pectoris, myocardial infarction type, heart failure type (ischemic cardiomyopathy), sudden death type five types.Wherein modal is angina pectoris, the most seriously myocardial infarction and sudden death two types.
Angina pectoris be one group due to acute temporary myocardial ischemia, anoxia the syndrome that rises:
(1) chest compressing sensation of asphyxia, vexed swollen sense, violent burn sample pain, general pain lasts 1-5 minute, occasionally have and reach 15 minutes, can spontaneous remission;
(2) before pain is often radiated to left shoulder, left arm, inner side is until little finger of toe is with nameless;
(3) pain occurs in heart burden (such as physical exertion increases, excessive direct stimulation and catch cold) time, can disappear after rest or sublingual administration nitroglycerin number minute;
(4) during panic attacks, can with (also can without) collapse, perspiration, short of breath, worry, cardiopalmus, feel sick or dizziness.
Myocardial infarction is the critical disease of coronary heart disease, usually have more angina pectoris attacks frequently with increase the weight of based on, the case (this kind of situation is the most dangerous, and Chang Yin does not guard against and causes sudden death) of the myocardial infarction that also happens suddenly with or without History of angina pectoris.Showing as of myocardial infarction:
(1), during burst after breastbone or the severe pain of pareordia, take on left, left arm or elsewhere radiation, and more than pain lasts half an hour, through to have a rest and buccal nitroglycerin can not be alleviated;
(2) short of breath, dizziness, feel sick, hyperhidrosis, pulse be trickle;
(3) clammy, greyish white, the severe disease sickly complexion of skin;
(4) unique performance of patient of about 1/10th is fainted or suffers a shock.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 20 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: coronary heart disease symptom disappears, body constitution recovers normal, observes half a year without recidivist;
Take a turn for the better: coronary heart disease symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy patients with coronary heart disease 150 example of the present invention, effective 145 examples of result, obvious effective rate is 96.67%, and take a turn for the better 3 examples, and improvement rate is 2%, and invalid 2 examples, total effective rate is 98.67%.

Claims (3)

1. treat a medicine for coronary heart disease, it is characterized in that: it is made up of the crude drug in following weight range:
Pericarpium Citri Reticulatae 8-15 gram of Radix Astragali 8-15 gram of Radix Rehmanniae Preparata 8-15 gram
Rhizoma Polygonati Odorati 8-15 gram of Radix Codonopsis 8-15 gram of Poria 8-15 gram
Rhizoma Dioscoreae 10-20 gram of Rhizoma Chuanxiong 15-25 gram of Radix Bupleuri 10-20 gram
Radix Aucklandiae 8-15 gram of Radix Rehmanniae 8-12 gram of Radix Paeoniae Rubra 8-12 gram
Fructus Aurantii 10-20 gram of Flos Carthami 10-20 gram of Radix Salviae Miltiorrhizae 8-12 gram
Radix Angelicae Sinensis 15-25 gram of Radix Adenophorae 8-15 gram of Semen Persicae 8-15 gram
Radix Ophiopogonis 8-15 gram of Ramulus Cinnamomi 15-25 gram Fructus Schisandrae Chinensis 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Pericarpium Citri Reticulatae 10 grams of Radixs Astragali 10 grams of Radix Rehmanniae Preparata 10 grams
10 grams, Rhizoma Polygonati Odorati 10 grams of Radix Codonopsis 10 grams of Poria
Rhizoma Dioscoreae 15 grams of Rhizoma Chuanxiongs 20 grams of Radix Bupleuri 15 grams
The Radix Aucklandiae 10 grams of Radix Rehmanniae 9 grams of Radix Paeoniae Rubra 9 grams
Fructus Aurantii 15 grams of Flos Carthamis 15 grams of Radix Salviae Miltiorrhizaes 9 grams
10 grams, Radix Angelicae Sinensis 20 grams of Radix Adenophoraes 10 grams of Semen Persicaes
10 grams of Ramulus Cinnamomi Radix Ophiopogonis, 20 grams of Fructus Schisandrae Chinensis 15 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
(2) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water;
(3) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
(4) Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
(5) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(6) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(7) Rhizoma Dioscoreae: pick clean impurity, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, pull out and slightly dry in the air, section is dried or is dried;
(8) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(9) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
(10) Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
(11) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
(12) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
(13) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
(14) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(15) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
(16) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(17) Radix Adenophorae: pick clean impurity, go reed, wash, slightly profit, section, well sifted dries;
(18) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
(19) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
(20) Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
(21) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(2) prepare
(1) Pericarpium Citri Reticulatae of described weight, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Polygonati Odorati, Radix Codonopsis, Poria, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Bupleuri, the Radix Aucklandiae, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Aurantii, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Adenophorae, Semen Persicae, Radix Ophiopogonis, Ramulus Cinnamomi, Fructus Schisandrae Chinensis medicine are decocted with water secondary, first time adds 6 times of water gagings and soaks, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor;
(2) add water the medicinal residues of filtration 3 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 6 doses to take decoction medicinal liquid.
CN201310387322.1A 2013-08-30 2013-08-30 Medicament for treating coronary heart disease and preparation method thereof Expired - Fee Related CN103432390B (en)

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CN106492125A (en) * 2016-12-09 2017-03-15 冉兆斌 A kind of treat medicine of coronary heart disease and preparation method thereof
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