CN103432274B - Medicament for treating migraine and preparation method thereof - Google Patents
Medicament for treating migraine and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating migraine and a preparation method thereof. The medicament is mainly prepared from drugs including ginseng, rhizoma atractylodis alba, tuckahoe, licorice, angelica, ligusticum wallichii and the like according to certain weight ratios. The medicament has the effects of promoting the circulation of qi to alleviate mental depression, promoting blood circulation to stop pain and relieving mental stress, and is high in effect taking speed and high in cure rate when used for treating migraine.
Description
Technical field
The present invention relates to one and treat migrainous medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Migraine is lopsided cephalic pain, often more obstinate, may regularly show effect, often with diseases such as E Xin ﹑ vomiting, eyes referred pains.Frequent Migraine outbreak will affect the life and work of patient, be exactly the most directly affect sleep, because do not have enough sleep, daytime, work was also greatly affected just out of spirits.And have some patients to be usually once the outbreak that works, extremely delay thing.Meanwhile, people suffers from headaches disease for a long time, and personality changes, and often disposition becomes irascible.Again because obstinate, life is subject to significant impact, and weak in mind, lose confidence, the time has been grown and will have a negative impact to the cardiovascular and cerebrovascular vessel of people, cerebral thrombosis after Headache attacks clinically, hypertension, and cerebral hemorrhage is clinical also more common.At present, because Western medicine cannot rapid, effective treatment migraine, and have more side effect, therefore, there is very large demand to the migrainous Chinese medicine of rapid, effective treatment in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the effectively migrainous medicine for the treatment of, thus completes the present invention.
Object of the present invention is just to provide one can effectively treat migrainous composition of medicine.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Gentianae Macrophyllae, Fructus Perillae medicine to combine, and is made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat migraine.Radix Ginseng is wherein selected to be that temperature, enters spleen, lung meridian, have strongly invigorating primordial QI because its nature and flavor are sweet micro-sweet, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizzy migraine, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and blood deficiency migraine is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled migraine and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Radix Gentianae Macrophyllae is selected to be because its nature and flavor toil, flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Fructus Perillae is selected to be that temperature, enter lung, large intestine channel, have the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation because its nature and flavor are pungent.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Ginseng 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Poria 15-25 gram
Radix Glycyrrhizae 25-35 gram of Radix Angelicae Sinensis 25-35 gram of Rhizoma Chuanxiong 25-35 gram
Radix Paeoniae Alba 10-20 gram of Radix Rehmanniae Preparata 10-20 gram of Radix Gentianae Macrophyllae 10-20 gram
Fructus Perillae 10-20 gram
Preferable amount is
20 grams, Radix Ginseng 20 grams of Rhizoma Atractylodis Macrocephalaes 20 grams of Poria
Radix Glycyrrhizae 30 grams of Radix Angelicae Sinensis 30 grams of Rhizoma Chuanxiongs 30 grams
The Radix Paeoniae Alba 15 grams of Radix Rehmanniae Preparata 15 grams of Radix Gentianae Macrophyllae 15 grams
Fructus Perillae 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Ginseng: except removing LU, cutting;
2, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
3, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
4, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
5, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
6, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
7, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
8, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
9, Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
10, Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries.
Two, prepare
By the Radix Ginseng of described weight, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Gentianae Macrophyllae, Fructus Perillae medicine, add water 8 times amount, soaks after 200 minutes, intense fire decocts boiling 35 minutes, use slow fire boiling again 35 minutes, filter and get final product, the medicinal liquid of filtration is divided into 3 doses and takes.
Medicine of the present invention has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain, effect of mind tranquilizing and the heart calming, and treatment migraine instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, often organize 15, wherein one group is normal amount toxicity test, another group is super quantity toxicity test, and normal amount group is 10ml/kg, and excess group is 20ml/kg, administering mode is administration by gavage administration, every day 2 times, be used in conjunction 7 days, observe administration reaction every day, result of the test shows that two groups of families exempt from diet activity normally, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 190 example for medical treatment, male patient 80 example, female patient 110 example.
2, diagnostic criteria
Migraine is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%.
Migraine main Types and clinical manifestation:
Migraine without aura is modal migraines, accounts for 80%.Premorbid can not have obvious premonitory symptom, also have some patients in performances such as premorbid spiritedness obstacle, fatigue, yawn, inappetence, general malaises, feminine menstrual risen, drink, on an empty stomach hungry time also can Provocative pain.Headache is many in slowly increasing the weight of, the side of recurrent exerbation or bilateral frontal temporal part pain, and in pulsation, durantedolore companion cervical muscle shrinks and can make complicated symptoms.Normal with symptoms such as Nausea and vomiting, photophobia, phonophobia, perspiration, general malaise, Scalp tenderness.Compared with migraine without aura, Migraine without aura has higher seizure frequency, can have a strong impact on patient work and life.
Migraine without aura accounts for migraineur's 10%.Before outbreak, can there be asthenia, the absent minded and prodrome such as to yawn a few hours to a few days.Have a headache before or headache occur time, often with reversible focal neurological symptom for tendency, the most common is visual aura, as blurred vision, dim spot, flash of light, bright spot bright line or metamorphopsia; Secondly be sensory aura, sensory symptoms is many in face-hands area distribution; Speech and motor aura rare.Premonitory symptom was generally formed gradually in 5 ~ 20 minutes, continued to be no more than 60 minutes; Different tendency can occur in succession.Headache occurs in 60 minutes in tendency simultaneously or after tendency, show as pulsatile headache after side or bilateral frontal temporal part or socket of the eye, normal with Nausea and vomiting, photophobia or phonophobia, pale or perspiration, polyuria, irritability, osmophobia and feeling of fatigue etc., visible Head And Face edema, Temporal Artery are outstanding.Activity can make headache increase the weight of, and can alleviate headache after sleep.Pain generally peaked at 1-2 hour, and continue 4-6 hour or tens hours, severe one can last a couple of days, and headache often has fatigue, asthenia, agitation, unable and appetite poor after disappearing.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 5 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, body constitution recovers normal, observes 1 year without recidivist;
Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered.
Invalid: not reach improvement standard person.
In above-mentioned treatment, by Drug therapy migraineur 190 example of the present invention, effective 183 examples of result, obvious effective rate is 96.32%, and take a turn for the better 5 examples, and improvement rate is 2.63%, and invalid 2 examples, total effective rate is 98.95%.
Claims (3)
1. treat a migrainous medicine, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Ginseng 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Poria 15-25 gram
Radix Glycyrrhizae 25-35 gram of Radix Angelicae Sinensis 25-35 gram of Rhizoma Chuanxiong 25-35 gram
Radix Paeoniae Alba 10-20 gram of Radix Rehmanniae Preparata 10-20 gram of Radix Gentianae Macrophyllae 10-20 gram
Fructus Perillae 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
20 grams, Radix Ginseng 20 grams of Rhizoma Atractylodis Macrocephalaes 20 grams of Poria
Radix Glycyrrhizae 30 grams of Radix Angelicae Sinensis 30 grams of Rhizoma Chuanxiongs 30 grams
The Radix Paeoniae Alba 15 grams of Radix Rehmanniae Preparata 15 grams of Radix Gentianae Macrophyllae 15 grams
Fructus Perillae 15 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Ginseng: except removing LU, cutting;
(2) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(3) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(4) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(5) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(6) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(7) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(8) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
(9) Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
(10) Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;
(2) prepare
By the Radix Ginseng of described weight, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Gentianae Macrophyllae, Fructus Perillae medicine, add water 8 times amount, soaks after 200 minutes, intense fire decocts boiling 35 minutes, use slow fire boiling again 35 minutes, filter and get final product, the medicinal liquid of filtration is divided into 3 doses and takes.
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