CN103623376B - Medication for treating prosopalgia and preparation method thereof - Google Patents

Medication for treating prosopalgia and preparation method thereof Download PDF

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CN103623376B
CN103623376B CN201310642832.9A CN201310642832A CN103623376B CN 103623376 B CN103623376 B CN 103623376B CN 201310642832 A CN201310642832 A CN 201310642832A CN 103623376 B CN103623376 B CN 103623376B
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rhizoma
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侯青兰
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侯青兰
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Abstract

The invention discloses a medication for treating prosopalgia and a preparation method thereof. The medication is mainly prepared by mixing the following medicine according to a proper weight ratio: fructus viticis, gentian, radix rehmanniae recen, chrysanthemum, radix paeoniae alba, folium mori, ligusticum wallichii, gypsum, and the like. The medication disclosed by the invention has the function of relieving nerve, promoting blood circulation to remove meridian obstruction, dispelling wind and spasmolysis, has a short course of treatment for treating prosopalgia, and takes effect quickly; the disease does not relapse once cured.

Description

One treats prosopalgic medicine and preparation method thereof
Technical field
The present invention relates to one and treat prosopalgic medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Trigeminal neuralgia is one of modal cranial nerve diseases, with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations.Trigeminal neuralgia is multiple is born in middle-aged and elderly people, R)L.The feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking.Pain lasts several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.At present, western medicine trigeminal neuralgia poor effect, and long-term taking Western medicine has more side effect, and therefore, the demand that people are very large to effectively treatment prosopalgic Chinese medicine existence.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the effectively prosopalgic medicine for the treatment of, thus completes the present invention.
Object of the present invention is just to provide one can effectively treat prosopalgic composition of medicine.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Fructus Viticis, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the prosopalgic recurrence of rapid, effective treatment.Wherein select Fructus Viticis to be because its nature and flavor toil, cool, enter liver, stomach, urinary bladder channel, have dispelling wind and heat pathogens, the function of the clear sharp head, controls anemopyretic cold, just, migraine, and toothache, pain in order eyeball.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat , Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle , Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Arisaema Cum Bile is selected to be that cool in nature, enter the heart, liver, lung three warp, have clearing away fire and eliminating phlegm, relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and coughed, phlegm-accumulating vertigo because its nature and flavor are bitter.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea , mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Bombyx Batryticatus is selected to be because its nature and flavor are pungent, salty, flat, return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Radix Glycyrrhizae is selected to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus , Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea , Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, control convulsion with spasms , epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells.Rhizoma Typhonii is selected to be that temperature, return stomach, Liver Channel, dispel the wind expectorant, and antispasmodic function controls apoplexy, facial hemiparalysis, facial paralysis, migraine, tetanus, tuberculous lymphadenitis, carbuncle because its nature and flavor are pungent.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Rhizoma Et Radix Notopterygii is selected to be that temperature, enter bladder, kidney channel, have loose exterior cold, wind-damp dispelling, the function in sharp joint, cure cold wind and cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore because its nature and flavor are worked hard.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.
The consumption of drug component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Fructus Viticis 10-20 cron gallbladder 10-20 gram of Radix Rehmanniae 10-20 gram
Flos Chrysanthemi 10-20 gram of Radix Paeoniae Alba 10-20 gram of Folium Mori 10-20 gram
Rhizoma Chuanxiong 10-20 gram of Gypsum Fibrosum 25-35 gram of Fructus Gardeniae 5-15 gram
Radix Scutellariae 5-15 gram of Rhizoma Coptidis 5-15 gram of Cortex Moutan 5-15 gram
Radix Saposhnikoviae 5-15 gram of Radix Bupleuri 5-15 gram of Arisaema Cum Bile 5-15 gram
Rhizoma Pinelliae 5-15 gram of Poria 5-15 gram of Fructus Aurantii 5-15 gram
Flos Carthami 3-9 gram of Bombyx Batryticatus 3-9 gram of Lumbricus 3-9 gram
Rhizoma Zingiberis Recens 3-9 gram of Semen Persicae 3-9 gram of Radix Glycyrrhizae 3-9 gram
Radix Angelicae Dahuricae 3-9 gram of Radix Paeoniae Rubra 3-9 gram of Herba Schizonepetae 3-9 gram
Rhizoma Cimicifugae 3-9 gram of Scorpio 3-9 gram of Rhizoma Typhonii 3-9 gram
Herba Menthae 3-9 gram of Rhizoma Et Radix Notopterygii 8-15 gram of Herba Asari 8-15 gram.
Preferable amount is
Fructus Viticis 15 cron gallbladder 15 grams of Radix Rehmanniae 15 grams
15 grams, Flos Chrysanthemi 15 grams of Radix Paeoniae Albas 15 grams of Folium Mori
Rhizoma Chuanxiong 15 grams of Gypsum Fibrosum 30 grams of Fructus Gardeniaes 10 grams
Radix Scutellariae 10 grams of Rhizoma Coptidis 10 grams of Cortex Moutans 10 grams
Radix Saposhnikoviae 10 grams of Radix Bupleuri 10 grams of Arisaema Cum Bile 10 grams
The Rhizoma Pinelliae 10 grams of Poria 10 grams of Fructus Aurantiis 10 grams
Flos Carthami 8 grams of Bombyx Batryticatus 8 grams of Lumbricuss 8 grams
8 grams, Rhizoma Zingiberis Recens 8 grams of Semen Persicaes 8 grams of Radix Glycyrrhizaes
The Radix Angelicae Dahuricae 8 grams of Radix Paeoniae Rubra 8 grams of Herba Schizonepetae 8 grams
Rhizoma Cimicifugae 8 grams of Scorpios 8 grams of Rhizoma Typhoniis 8 grams
Herba Menthae 8 grams of Rhizoma Et Radix Notopterygiis 10 grams of Herba Asaris 10 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;
2, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
3, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
4, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;
5, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
6, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
7, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
8, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;
9, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;
10, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
11, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
12, Cortex Moutan: pick decontamination, cleans, runs through, and section, dries;
13, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
14, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
15, Arisaema Cum Bile: get crude drug, picks decontamination;
16, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
17, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
18, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
19, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
20, Bombyx Batryticatus: get crude drug, removes residual silk, impurity;
21, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
22, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
23, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
24, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;
25, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
26, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
27, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
28, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
29, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
30, Rhizoma Typhonii: get crude drug, removing impurity, cleaning, drying;
31, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;
32, Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;
33, Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries.
Two, prepare
1, by the Fructus Viticis of described weight, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine decocts with water twice, add water 8 times amount for the first time, soak after 150 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor.
3, merge twice decoction liquor, mixing and stirring, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 3 doses.
Medicine of the present invention has mind tranquilizing and the heart calming, promoting blood circulation to remove obstruction in the collateral, and the function of expelling wind to relieve convulsion, is used for the treatment of trigeminal neuralgia, short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The prosopalgic clinical observation material of [test example 2] Drug therapy of the present invention
1, physical data
Accept out-patient's totally 215 examples for medical treatment.
2, diagnostic criteria
Painful area: R)L, pain by face, oral cavity or lower jaw certain a bit to be diffused into nervi trigeminus one or more, the most common with second, the 3rd morbidity, first person is rare.Its pain dimensions absolutely not surmounts facial center line, is also no more than nervi trigeminus distributed areas.There is bilateral trigeminal neuralgia person once in a while, account for 3%;
Characteristic of pain: as cut, acupuncture, the violent pain unbearably of sample of tearing, burn or shock by electricity, even overwhelmed with sorrow;
The rule of pain: prosopalgic outbreak is normal without omen, and panic attacks is generally regular.Each panic attacks time is stopped by 1 ~ 2 minute suddenly by only last for several seconds.During initial stage onset, attack times is less, and the intermission is also long, several minutes, a few hours, not etc. with PD, outbreak was not frequent gradually, and the intermission shortens gradually, and pain also increases the weight of and violent gradually.Night, panic attacks reduced.Intermission is without any discomfort; 5, risk factor: speak, have a meal, wash one's face, shave, brush teeth and wind etc. all can be shown effect by Provocative pain, so that patient's lethargy is depressed, takes action overcautious, even dare not wash one's face, brushes teeth, take food, speaks also careful, lest cause outbreak;
Expression and facial area change: the activities such as outbreak pipes down suddenly often, feed, pain side surface part can present spasm, i.e. " cramp ", frown and grit one's teeth, dehisce to cover order, or firmly rub face with palm so that local skin is coarse, thicken, milphae, conjunctival congestion, shed tears and sialorrhea.Expression is in psychentonia, anxiety state;
Neurologic check: absence of signs, minority has facial perception to go down.This type of patient should inquire medical history further, and especially whether inquiry previously has hypertension history, carries out comprehensive neurologic check, comprises that waist is worn if desired, basis cranii and lnner stripe take the photograph the inspections such as sheet, cerebral CT, MRI, differentiate to help with secondary trigeminal neuralgia.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, body constitution recovers normal, observes half a year without recidivist;
Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy affected nerves of patients with trigeminal neuralgia 215 example of the present invention, effective 206 examples of result, obvious effective rate is 95.81%, and take a turn for the better 6 examples, and improvement rate is 2.79%, and invalid 3 examples, total effective rate is 98.6%.

Claims (3)

1. treat a prosopalgic medicine, it is characterized in that: it is made up of the crude drug in following weight range:
Fructus Viticis 10-20 cron gallbladder 10-20 gram of Radix Rehmanniae 10-20 gram
Flos Chrysanthemi 10-20 gram of Radix Paeoniae Alba 10-20 gram of Folium Mori 10-20 gram
Rhizoma Chuanxiong 10-20 gram of Gypsum Fibrosum 25-35 gram of Fructus Gardeniae 5-15 gram
Radix Scutellariae 5-15 gram of Rhizoma Coptidis 5-15 gram of Cortex Moutan 5-15 gram
Radix Saposhnikoviae 5-15 gram of Radix Bupleuri 5-15 gram of Arisaema Cum Bile 5-15 gram
Rhizoma Pinelliae 5-15 gram of Poria 5-15 gram of Fructus Aurantii 5-15 gram
Flos Carthami 3-9 gram of Bombyx Batryticatus 3-9 gram of Lumbricus 3-9 gram
Rhizoma Zingiberis Recens 3-9 gram of Semen Persicae 3-9 gram of Radix Glycyrrhizae 3-9 gram
Radix Angelicae Dahuricae 3-9 gram of Radix Paeoniae Rubra 3-9 gram of Herba Schizonepetae 3-9 gram
Rhizoma Cimicifugae 3-9 gram of Scorpio 3-9 gram of Rhizoma Typhonii 3-9 gram
Herba Menthae 3-9 gram of Rhizoma Et Radix Notopterygii 8-15 gram of Herba Asari 8-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Fructus Viticis 15 cron gallbladder 15 grams of Radix Rehmanniae 15 grams
15 grams, Flos Chrysanthemi 15 grams of Radix Paeoniae Albas 15 grams of Folium Mori
Rhizoma Chuanxiong 15 grams of Gypsum Fibrosum 30 grams of Fructus Gardeniaes 10 grams
Radix Scutellariae 10 grams of Rhizoma Coptidis 10 grams of Cortex Moutans 10 grams
Radix Saposhnikoviae 10 grams of Radix Bupleuri 10 grams of Arisaema Cum Bile 10 grams
The Rhizoma Pinelliae 10 grams of Poria 10 grams of Fructus Aurantiis 10 grams
Flos Carthami 8 grams of Bombyx Batryticatus 8 grams of Lumbricuss 8 grams
8 grams, Rhizoma Zingiberis Recens 8 grams of Semen Persicaes 8 grams of Radix Glycyrrhizaes
The Radix Angelicae Dahuricae 8 grams of Radix Paeoniae Rubra 8 grams of Herba Schizonepetae 8 grams
Rhizoma Cimicifugae 8 grams of Scorpios 8 grams of Rhizoma Typhoniis 8 grams
Herba Menthae 8 grams of Rhizoma Et Radix Notopterygiis 10 grams of Herba Asaris 10 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;
(2) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
(3) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
(4) Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;
(5) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(6) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
(7) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(8) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;
(9) Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;
(10) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
(11) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
(12) Cortex Moutan: pick decontamination, cleans, runs through, and section, dries;
(13) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(14) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
(15) Arisaema Cum Bile: get crude drug, picks decontamination;
(16) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
(17) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(18) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
(19) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(20) Bombyx Batryticatus: get crude drug, removes residual silk, impurity;
(21) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
(22) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
(23) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
(24) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;
(25) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
(26) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
(27) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(28) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(29) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
(30) Rhizoma Typhonii: get crude drug, removing impurity, cleaning, drying;
(31) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;
(32) Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;
(33) Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;
(2) prepare
(1) by the Fructus Viticis of described weight, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine decocts with water secondary, add water 8 times amount for the first time, soak after 150 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,
(2) add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor;
(3) twice decoction liquor is merged, mixing and stirring, then with slow fire boiling 10 minutes and get final product.
CN201310642832.9A 2013-12-05 2013-12-05 Medication for treating prosopalgia and preparation method thereof Expired - Fee Related CN103623376B (en)

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