CN103623376A - Medication for treating prosopalgia and preparation method thereof - Google Patents
Medication for treating prosopalgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medication for treating prosopalgia and a preparation method thereof. The medication is mainly prepared by mixing the following medicine according to a proper weight ratio: fructus viticis, gentian, radix rehmanniae recen, chrysanthemum, radix paeoniae alba, folium mori, ligusticum wallichii, gypsum, and the like. The medication disclosed by the invention has the function of relieving nerve, promoting blood circulation to remove meridian obstruction, dispelling wind and spasmolysis, has a short course of treatment for treating prosopalgia, and takes effect quickly; the disease does not relapse once cured.
Description
Technical field
The present invention relates to a kind of prosopalgic medicine and preparation method thereof for the treatment of, belong to the field of Chinese medicines.
Technical background
Trigeminal neuralgia is one of modal cranial nerve diseases, and the violent pain of the paroxysmal of outbreak repeatedly of take in a side surface part nervi trigeminus areal area is main manifestations.The multiple middle-aged and elderly people of being born in of trigeminal neuralgia, R)L.This sick feature is: in Head And Face nervi trigeminus distributed areas, morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain in the time of all can causing paroxysmal while even walking.Pain is lasted several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.At present, western medicine trigeminal neuralgia poor effect, and long-term taking Western medicine has more side effect, and therefore, there is very large demand to the prosopalgic Chinese medicine of effective treatment in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the prosopalgic medicine of effective treatment, thereby has completed the present invention.
Object of the present invention is just to provide a kind ofly can effectively treat prosopalgic composition of medicine.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Fructus Viticis, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus can the prosopalgic recurrence of rapid, effective treatment.Wherein selecting Fructus Viticis is because its nature and flavor toil, cool, enters liver, stomach, and urinary bladder channel, has dispelling wind and heat pathogens, and the clear sharp head's function, controls anemopyretic cold, just, migraine, and toothache, pain in order eyeball.Select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, there is eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Select Flos Chrysanthemi to be because its nature and flavor sweetness and bitterness is cool, enter lung, Liver Channel, has dispelling wind, the heat that disappears, and improving eyesight, the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Folium Mori to be because its property bitter but sweet flavor is cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select Rhizoma Chuanxiong to be because its nature and flavor are pungent, temperature, enters liver, gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Gypsum Fibrosum to be because its property acrid-sweet flavor is cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, there is heat clearing away, pathogenic fire purging, the function of removing heat from blood, controls calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia, spits blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Radix Scutellariae to be because its nature and flavor bitter cold enters cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Rhizoma Coptidis to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, there is pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever while controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis, tells, nosebleed, hematochezia, quenches one's thirst, and infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Selecting Radix Saposhnikoviae is that temperature, enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.Select Radix Bupleuri to be because its nature and flavor are bitter, cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain, and bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Arisaema Cum Bile to be because its nature and flavor are bitter, cool in nature, enter the heart, liver, lung three warps, have clearing away fire and eliminating phlegm, the relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Selecting Fructus Aurantii is because its nature and flavor toil, cool, enters lung, spleen, large intestine channel, has dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, controls chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Bombyx Batryticatus to be because its nature and flavor are pungent, salty, flat, return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, there is heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enters lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, opens the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, there are and middle emergency lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, and carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Herba Schizonepetae to be because its nature and flavor are pungent, temperature, enters lung, Liver Channel, delivers, dispel the wind, and the function for the treatment of blood disorders, parch to black hemostasis, the heating that cures cold, headache, laryngopharynx swelling and pain, apoplexy locked mouth, spits blood, and epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select Rhizoma Cimicifugae to be because the sweet pungent micro-hardship of its nature and flavor is cool, enter lung, spleen, stomach warp, have yang invigorating, deliver rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, and laryngalgia, aphtha scar, macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, controls convulsion with spasms ， epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer is swollen.Select Rhizoma Typhonii to be because its nature and flavor are pungent, temperature, returns stomach, Liver Channel, the expectorant that dispels the wind, and antispasmodic function, controls apoplexy, facial hemiparalysis, facial paralysis, migraine, tetanus, tuberculous lymphadenitis, carbuncle.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, wards off dirtyly, and the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Select Rhizoma Et Radix Notopterygii to be because its nature and flavor are arduous, temperature, enters bladder, kidney channel, has loose exterior cold, wind-damp dispelling, and the function in sharp joint, the wind and cold that cures cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.Select Herba Asari to be because its nature and flavor are pungent, temperature, enters lung, kidney channel, dispel the wind, and cold expelling, row water, opens the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.
The consumption of drug component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
10-20 gram of Radix Rehmanniae 10-20 gram of Fructus Viticis 10-20 cron gallbladder
Flos Chrysanthemi 10-20 gram of Radix Paeoniae Alba 10-20 gram of Folium Mori 10-20 gram
Rhizoma Chuanxiong 10-20 gram of Gypsum Fibrosum 25-35 gram of Fructus Gardeniae 5-15 gram
Radix Scutellariae 5-15 gram of Rhizoma Coptidis 5-15 gram of Cortex Moutan 5-15 gram
Radix Saposhnikoviae 5-15 gram of Radix Bupleuri 5-15 gram of Arisaema Cum Bile 5-15 gram
Rhizoma Pinelliae 5-15 gram of Poria 5-15 gram of Fructus Aurantii 5-15 gram
Flos Carthami 3-9 gram of Bombyx Batryticatus 3-9 gram of Lumbricus 3-9 gram
Rhizoma Zingiberis Recens 3-9 gram of Semen Persicae 3-9 gram of Radix Glycyrrhizae 3-9 gram
Radix Angelicae Dahuricae 3-9 gram of Radix Paeoniae Rubra 3-9 gram of Herba Schizonepetae 3-9 gram
Rhizoma Cimicifugae 3-9 gram of Scorpio 3-9 gram of Rhizoma Typhonii 3-9 gram
Herba Menthae 3-9 gram of Rhizoma Et Radix Notopterygii 8-15 gram of Herba Asari 8-15 gram.
Preferable amount is
15 grams of 15 grams of Radix Rehmanniae of Fructus Viticis 15 cron gallbladder
15 grams, 15 grams of Folium Mori of 15 grams of Radix Paeoniae Albas of Flos Chrysanthemi
10 grams of 30 grams of Fructus Gardeniaes of 15 grams of Gypsum Fibrosum of Rhizoma Chuanxiong
10 grams of 10 grams of Cortex Moutans of 10 grams of Rhizoma Coptidis of Radix Scutellariae
10 grams of 10 grams of Arisaema Cum Bile of 10 grams of Radix Bupleuri of Radix Saposhnikoviae
10 grams of 10 grams of Fructus Aurantiis of 10 grams of Poria of the Rhizoma Pinelliae
8 grams of 8 grams of Lumbricuss of 8 grams of Bombyx Batryticatus of Flos Carthami
8 grams, 8 grams of Radix Glycyrrhizaes of 8 grams of Semen Persicaes of Rhizoma Zingiberis Recens
8 grams of 8 grams of Herba Schizonepetae of 8 grams of Radix Paeoniae Rubra of the Radix Angelicae Dahuricae
8 grams of 8 grams of Rhizoma Typhoniis of 8 grams of Scorpios of Rhizoma Cimicifugae
10 grams of 10 grams of Herba Asaris of 8 grams of Rhizoma Et Radix Notopterygiis of Herba Menthae.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;
2, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
3, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
4, Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
5, the Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
6, Folium Mori: choose decontamination, rub with the hands brokenly, winnow with a dustpan destemming, sieve removes spare;
7, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
8, Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
9, Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
10, Radix Scutellariae: choose decontamination, remove residual stem, infiltrate or put in boiled water and slightly soak and pull out with cold water, section, dries;
11, Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section, dries in the shade;
12, Cortex Moutan: choose decontamination, clean, run through, section, dries;
13, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
14, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
15, Arisaema Cum Bile: get crude drug, choose decontamination;
16, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
17, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
18, Fructus Aurantii: remove flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
19, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
20, Bombyx Batryticatus: get crude drug, remove residual silk, impurity;
21, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
22, Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
23, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
24, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;
25, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
26, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
27, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;
28, Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
29, Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
30, Rhizoma Typhonii: get crude drug, remove impurity, cleaning, drying;
31, Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
32, Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dries;
33, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries.
Two, preparation
1, by the Fructus Viticis of described weight, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine decocts with water twice, add for the first time 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time.
3, merge decoction liquor twice, mixing and stirring, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 3 doses.
Medicine of the present invention has mind tranquilizing and the heart calming, promoting blood circulation to remove obstruction in the collateral, and the function of expelling wind to relieve convulsion, is used for the treatment of trigeminal neuralgia, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The prosopalgic clinical observation material of [test example 2] Drug therapy of the present invention
1, physical data
Accept out-patient's totally 215 examples for medical treatment.
2, diagnostic criteria
Painful area: R)L, it is one or more that pain a bit starts to be diffused into nervi trigeminus by certain of face, oral cavity or lower jaw, and the most common with second, the 3rd morbidity, first person is rare.Its pain dimensions surmounts facial center line anything but, is also no more than nervi trigeminus distributed areas.There is once in a while bilateral trigeminal neuralgia person, account for 3%;
Characteristic of pain: as cut, acupuncture, tear, burn or the violent pain unbearably of the sample that shocks by electricity, even overwhelmed with sorrow;
The rule of pain: prosopalgic outbreak is often without omen, and pain outbreak is generally regular.Each pain duration of seizure stops suddenly by only continuing several seconds to 1～2 minute.Initial stage during onset attack times less, the intermission is also long, not etc., with PD, do not show effect frequent gradually in several minutes, a few hours, the intermission shortens gradually, pain also increases the weight of and violent gradually.Night, pain outbreak reduced.Intermission is without any discomfort; 5, risk factor: speak, have a meal, wash one's face, shave, brush teeth and wind etc. all can be shown effect by Provocative pain, so that patient's lethargy is depressed, takes action overcautious, even dare not wash one's face, brushes teeth, take food, and speaks also careful, lest cause outbreak;
Expression and facial area change: the activities such as cut is often spoken, feed show effect, pain side surface part can present spasm, i.e. " cramp ", frown and grit one's teeth, dehisce to cover order, or firmly rub face so that local skin is coarse, thicken, milphae, conjunctival congestion, shed tears and sialorrhea with palm.Expression is psychentonia, anxiety state;
Neurologic check: absence of signs, minority has facial perception to go down.This type of patient should further inquire medical history, and especially whether inquiry previously has hypertension history, carries out comprehensive neurologic check, comprises if desired that waist is worn, basis cranii and interior auditory canal take the photograph the inspections such as sheet, cranium brain CT, MRI, to help with secondary trigeminal neuralgia, differentiates.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 4 courses for the treatment of.
4, efficacy assessment standard
Effective: transference cure, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy affected nerves of patients with trigeminal neuralgia 215 examples of the present invention, effective 206 examples of result, obvious effective rate is 95.81%, 6 examples that take a turn for the better, and improvement rate is 2.79%, invalid 3 examples, total effective rate is 98.6%.
Claims (3)
1. treat a prosopalgic medicine, it is characterized in that: it is to be made by the crude drug in following weight range:
10-20 gram of Radix Rehmanniae 10-20 gram of Fructus Viticis 10-20 cron gallbladder
Flos Chrysanthemi 10-20 gram of Radix Paeoniae Alba 10-20 gram of Folium Mori 10-20 gram
Rhizoma Chuanxiong 10-20 gram of Gypsum Fibrosum 25-35 gram of Fructus Gardeniae 5-15 gram
Radix Scutellariae 5-15 gram of Rhizoma Coptidis 5-15 gram of Cortex Moutan 5-15 gram
Radix Saposhnikoviae 5-15 gram of Radix Bupleuri 5-15 gram of Arisaema Cum Bile 5-15 gram
Rhizoma Pinelliae 5-15 gram of Poria 5-15 gram of Fructus Aurantii 5-15 gram
Flos Carthami 3-9 gram of Bombyx Batryticatus 3-9 gram of Lumbricus 3-9 gram
Rhizoma Zingiberis Recens 3-9 gram of Semen Persicae 3-9 gram of Radix Glycyrrhizae 3-9 gram
Radix Angelicae Dahuricae 3-9 gram of Radix Paeoniae Rubra 3-9 gram of Herba Schizonepetae 3-9 gram
Rhizoma Cimicifugae 3-9 gram of Scorpio 3-9 gram of Rhizoma Typhonii 3-9 gram
Herba Menthae 3-9 gram of Rhizoma Et Radix Notopterygii 8-15 gram of Herba Asari 8-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
15 grams of 15 grams of Radix Rehmanniae of Fructus Viticis 15 cron gallbladder
15 grams, 15 grams of Folium Mori of 15 grams of Radix Paeoniae Albas of Flos Chrysanthemi
10 grams of 30 grams of Fructus Gardeniaes of 15 grams of Gypsum Fibrosum of Rhizoma Chuanxiong
10 grams of 10 grams of Cortex Moutans of 10 grams of Rhizoma Coptidis of Radix Scutellariae
10 grams of 10 grams of Arisaema Cum Bile of 10 grams of Radix Bupleuri of Radix Saposhnikoviae
10 grams of 10 grams of Fructus Aurantiis of 10 grams of Poria of the Rhizoma Pinelliae
8 grams of 8 grams of Lumbricuss of 8 grams of Bombyx Batryticatus of Flos Carthami
8 grams, 8 grams of Radix Glycyrrhizaes of 8 grams of Semen Persicaes of Rhizoma Zingiberis Recens
8 grams of 8 grams of Herba Schizonepetae of 8 grams of Radix Paeoniae Rubra of the Radix Angelicae Dahuricae
8 grams of 8 grams of Rhizoma Typhoniis of 8 grams of Scorpios of Rhizoma Cimicifugae
10 grams of 10 grams of Herba Asaris of 8 grams of Rhizoma Et Radix Notopterygiis of Herba Menthae.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;
(2) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(3) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
(4) Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
(5) Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(6) Folium Mori: choose decontamination, rub with the hands brokenly, winnow with a dustpan destemming, sieve removes spare;
(7) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(8) Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
(9) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(10) Radix Scutellariae: choose decontamination, remove residual stem, infiltrate or put in boiled water and slightly soak and pull out with cold water, section, dries;
(11) Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section, dries in the shade;
(12) Cortex Moutan: choose decontamination, clean, run through, section, dries;
(13) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(14) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
(15) Arisaema Cum Bile: get crude drug, choose decontamination;
(16) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(17) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(18) Fructus Aurantii: remove flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;
(19) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(20) Bombyx Batryticatus: get crude drug, remove residual silk, impurity;
(21) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
(22) Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
(23) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
(24) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;
(25) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
(26) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
(27) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;
(28) Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(29) Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
(30) Rhizoma Typhonii: get crude drug, remove impurity, cleaning, drying;
(31) Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
(32) Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dries;
(33) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;
(2) preparation
(1) by the Fructus Viticis of described weight, Radix Gentianae, Radix Rehmanniae, Flos Chrysanthemi, the Radix Paeoniae Alba, Folium Mori, Rhizoma Chuanxiong, Gypsum Fibrosum, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Moutan, Radix Saposhnikoviae, Radix Bupleuri, Arisaema Cum Bile, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Flos Carthami, Bombyx Batryticatus, Lumbricus, Rhizoma Zingiberis Recens, Semen Persicae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Herba Schizonepetae, Rhizoma Cimicifugae, Scorpio, Rhizoma Typhonii, Herba Menthae, Rhizoma Et Radix Notopterygii, Herba Asari medicine decocts with water secondary, add for the first time 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time,
(2) medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time;
(3) merge decoction liquor twice, mixing and stirring, then with slow fire boiling 10 minutes and get final product.
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| CN104173517A (en) * | 2014-09-03 | 2014-12-03 | 张士远 | Traditional Chinese medicine preparation for treating primary trigeminal neuralgia and preparation methods |
| CN104208308A (en) * | 2014-08-19 | 2014-12-17 | 李新民 | Formula treating trigeminal neuralgia |
| CN104800788A (en) * | 2015-04-20 | 2015-07-29 | 郭巍 | Traditional Chinese medicine formula for treating postoperative prosopalgia |
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| CN103028018A (en) * | 2011-09-29 | 2013-04-10 | 刘清友 | Preparation method of traditional Chinese medicine prescription for treating prosopalgia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104208308A (en) * | 2014-08-19 | 2014-12-17 | 李新民 | Formula treating trigeminal neuralgia |
| CN104173517A (en) * | 2014-09-03 | 2014-12-03 | 张士远 | Traditional Chinese medicine preparation for treating primary trigeminal neuralgia and preparation methods |
| CN104800788A (en) * | 2015-04-20 | 2015-07-29 | 郭巍 | Traditional Chinese medicine formula for treating postoperative prosopalgia |
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