CN102872443B - Drug for treating migraine and preparation method thereof - Google Patents

Drug for treating migraine and preparation method thereof Download PDF

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CN102872443B
CN102872443B CN2012104166223A CN201210416622A CN102872443B CN 102872443 B CN102872443 B CN 102872443B CN 2012104166223 A CN2012104166223 A CN 2012104166223A CN 201210416622 A CN201210416622 A CN 201210416622A CN 102872443 B CN102872443 B CN 102872443B
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radix
rhizoma
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CN102872443A (en
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牛健坤
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Abstract

The invention discloses a drug for treating migraine and a preparation method thereof. The drug for treating the migraine is mainly prepared from the following traditional Chinese medicines in a certain weight ratio: radix rehmanniae recen, gastrodia elata, earthworm, safflower carthamus, Radix Paeoniae Rubra, Ligusticum wallichii, notopterygium root, chrysanthemum, radix gentianae, lithospermum, plantain seed, radix paeoniae alba, Ledebouriella seseloides Wolff, asarum, cinnamon and the like. The drug disclosed by the invention has functions of tonifying spleen and harmonizing stomach and calming heart to soothe the nerves. The drug is fast in effect when being used for treating the migraine; the course of treatment is short; the migraine cannot relapse; and the cure rate is high.

Description

A kind of migrainous medicine and preparation method thereof for the treatment of
Technical field
The present invention relates to a kind of migrainous medicine and preparation method thereof for the treatment of, belong to the field of Chinese medicines.
Background technology
Migraine is a kind of pulsation headache of repeatedly showing effect, and belongs to " rich and influential family " in numerous headache types.Before its outbreak, the tendencys such as flash of light, blurred vision, numb limbs and tense tendons are often arranged, approximate number minute the pain that a side head one is jumped occurred to about 1 hour, and aggravation gradually, until after occurring feeling sick, vomitting, sensation just have take a turn for the better, in quiet, dark surrounds or headache alleviation after sleep.Can be with nerve, mental function disorder before headache occurs or during outbreak.At present, doctor trained in Western medicine adopts analgesics and tranquilizer alleviating pain more, but the side effect of Western medicine is large.Therefore, there is great demand in people to the migrainous Chinese medicine of effective treatment.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the migrainous medicine of effective treatment, thereby has completed the present invention.
Purpose of the present invention just is to provide a kind ofly can treat migrainous composition of medicine.
Another object of the present invention just has been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Rehmanniae, Rhizoma Gastrodiae, Lumbricus, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Flos Chrysanthemi, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Semen Plantaginis, the Radix Paeoniae Alba, Radix Saposhnikoviae, Herba Asari, Cortex Cinnamomi, Radix Puerariae, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Ginseng, Poria, the Radix Astragali, Fructus Hordei Germinatus, Semen Platycladi, Radix Rehmanniae Preparata, Massa Medicata Fermentata, Herba Menthae, Herba Schizonepetae, Rhizoma Corydalis, Scorpio, Radix Bupleuri, Semen Persicae, Rhizoma Zingiberis Recens medicine to be combined, make each efficacy of drugs produce synergism these drug regimens, thus can the migrainous recurrence of fast treating.Wherein select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, control the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, send out the speckle dermexanthesis.Select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, endogenous wind stopping is arranged, the function of arresting convulsion, control dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, little Jing Epilepsy wind symptom.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, heat clearing away is arranged, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Selecting Flos Carthami is that temperature, enter the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged because of its nature and flavor suffering, and the function of blood stasis removing pain relieving is controlled amenorrhea , mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Radix Paeoniae Rubra to be because its nature and flavor hardship is slightly cold, return Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea , Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Selecting Rhizoma Chuanxiong is because its nature and flavor suffering, and temperature, enter liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Rhizoma Et Radix Notopterygii to be because its nature and flavor are arduous, temperature, enter bladder, kidney channel, and loose exterior cold is arranged, wind-damp dispelling, and the function in sharp joint, the wind and cold that cures cold, have a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.Select Flos Chrysanthemi to be because its nature and flavor sweetness and bitterness is cool, enter lung, Liver Channel, have dispelling wind, the heat that disappears, and improving eyesight, the function of removing toxic substances, control headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Select Radix Gentianae to be because its nature and flavor hardship is cold, enter liver, gallbladder meridian, the eliminating pathogen in the liver excess-fire is arranged, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat , Jing Epilepsy, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the carbuncle skin infection, scrotum swells and ache, the pudendum pruritus due to damp pathogen.Selecting Radix Arnebiae (Radix Lithospermi) is because its nature and flavor hardship, cold, enters percardium, Liver Channel, and removing heat from blood is arranged, and invigorates blood circulation, and the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, and purpura, tell, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, diuretic is arranged, heat clearing away, improving eyesight, the function of eliminating the phlegm, control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Selecting Radix Saposhnikoviae is that temperature, enter bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, control affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Selecting Herba Asari is that temperature, enter lung, kidney channel because of its nature and flavor suffering, dispel the wind, and cold expelling, row water, open the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Selecting Cortex Cinnamomi is that heat, enter kidney, spleen, urinary bladder channel, and the complement sun is arranged, warming the spleen and stomach, removing accumulated cold because of its property acrid-sweet flavor, the function of promoting blood circulation, control decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, enter spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, cure the wound cold, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, has loose bowels, dysentery, abnormal pigmentary deposit on the skin is examined not saturating, hypertension, angina pectoris, deafness.Select Rhizoma Cyperi to be because the hot micro-hard work of its nature and flavor is flat, enter liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, the dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Ginseng to be because its nature and flavor are sweet micro-sweet, temperature, enter spleen, lung meridian, and strongly invigorating primordial QI is arranged, Gu de-, promote the production of body fluid, the function of calming the nerves, control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enter lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor, enter spleen, stomach warp, and have and help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, control food stagnation and do not disappear, distension and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Semen Platycladi to be because its nature and flavor are sweet, flat, enter the heart, liver, spleen channel, tranquilizing by nourishing the heart is arranged, the function of loosening bowel to relieve constipation, control palpitation with fear, insomnia, seminal emission, night sweat, the function of constipation.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enter liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quench one's thirst, frequency of micturition, deafness, blurred vision.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm enters spleen, stomach warp, invigorating the spleen and regulating the stomach is arranged, the function helped digestion in adjusting, control retention of food and drink, feeling of stuffiness in chest abdominal distention, and vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.Selecting Herba Menthae is because its nature and flavor suffering, cool, enters lung, Liver Channel, and dispelling wind is arranged, and heat radiation is warded off dirtyly, and the function of removing toxic substances, control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Selecting Herba Schizonepetae is that temperature, enter lung, Liver Channel, delivers because of its nature and flavor suffering, dispel the wind, and the function for the treatment of blood disorders, the parch to black hemostasis, the heating that cures cold, headache, laryngopharynx swelling and pain, the apoplexy locked mouth, spit blood, and epistaxis, have blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enter liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulate the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia , mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select scorpio to be because the salty suffering of its nature and flavor is flat, poisonous, dispel the wind, stop convulsion, dredging collateral, the function of removing toxic substances, control convulsion , Dian Epilepsy, apoplexy, hemiplegia, Kou Yan is oblique, antimigraine, arthralgia due to wind-dampness, lockjaw, scrofula, the rubella sore is swollen.Select Radix Bupleuri to be because its nature and flavor hardship is cool, enter liver, gallbladder meridian, reconciling superficies and interior is arranged, soothing the liver, the function of yang invigorating, control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selecting Rhizoma Zingiberis Recens is because its nature and flavor suffering, and temperature, enter lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, open the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breath with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.
The specific embodiment
The drug dose of component of the present invention is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Radix Rehmanniae 10-30 gram Rhizoma Gastrodiae 8-22 gram Lumbricus 10-20 gram
Flos Carthami 4-12 gram Radix Paeoniae Rubra 10-22 gram Rhizoma Chuanxiong 4-12 gram
Rhizoma Et Radix Notopterygii 8-18 gram Flos Chrysanthemi 10-20 cron gallbladder 4-12 gram
Radix Arnebiae (Radix Lithospermi) 10-20 gram Semen Plantaginis 10-22 gram Radix Paeoniae Alba 10-20 gram
Radix Saposhnikoviae 10-28 gram Herba Asari 2-8 gram Cortex Cinnamomi 3-12 gram
Radix Puerariae 10-20 gram Rhizoma Cyperi 8-12 gram Radix Angelicae Sinensis 4-15 gram
Radix Ginseng 10-20 gram Poria 8-15 gram Radix Astragali 6-22 gram
Fructus Hordei Germinatus 6-18 gram Semen Platycladi 10-20 gram Radix Rehmanniae Preparata 10-22 gram
Massa Medicata Fermentata 5-12 gram Herba Menthae 12-22 gram Herba Schizonepetae 10-20 gram
Rhizoma Corydalis 8-22 gram Scorpio 8-15 gram Radix Bupleuri 8-17 gram
Semen Persicae 8-22 gram Rhizoma Zingiberis Recens 8-14 gram
Wherein, be preferably
Radix Rehmanniae 20 gram Rhizoma Gastrodiae 15 gram Lumbricus 15 grams
Flos Carthami 8 gram Radix Paeoniae Rubra 15 gram Rhizoma Chuanxiong 8 grams
Rhizoma Et Radix Notopterygii 10 gram Flos Chrysanthemi 15 cron gallbladder 8 grams
The Radix Arnebiae (Radix Lithospermi) 15 gram Semen Plantaginis 13 gram Radix Paeoniae Alba 20 grams
Radix Saposhnikoviae 15 gram Herba Asari 6 gram Cortex Cinnamomi 10 grams
Radix Puerariae 15 gram Rhizoma Cyperi 10 gram Radix Angelicae Sinensis 10 grams
The Radix Ginseng 15 gram Poria 9 gram Radix Astragali 13 grams
Fructus Hordei Germinatus 10 gram Semen Platycladi 15 gram Radix Rehmanniae Preparata 15 grams
Massa Medicata Fermentata 10 gram Herba Menthae 15 gram Herba Schizonepetae 15 grams
Rhizoma Corydalis 12 gram Scorpio 10 gram Radix Bupleuri 10 grams
Semen Persicae 10 gram Rhizoma Zingiberis Recens 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
2, Rhizoma Gastrodiae: Rhizoma Gastrodiae slice is laid on the watch core paper that sprayed water, puts in pot, with slow fire, burn to the paper color sallow, constantly tablet is stirred to the two sides strong yellow for the degree;
3, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
4, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
5, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, clean, runs through, and shave, drying, sieve removes chip;
6, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;
7, Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;
8, Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
9, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
10, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dry;
11, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
12, the Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
13, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
14, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dry;
15, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, by warm water, infiltrates a moment, and section, dry;
16, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dry in time;
17, Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;
18, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
19, Radix Ginseng: except removing LU, cutting;
20, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
21, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
22, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;
23, Semen Platycladi: choose clean impurity, remove residual shell and plant skin;
24, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, cut into slices, drying;
25, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in the heat pot, the cigarette of having waited, pour Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
26, Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
27, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;
28, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
29, Scorpio: clear water floats the matter that desalts, and dry, or the low baking temperature roasting is used;
30, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
31, Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
32, Rhizoma Zingiberis Recens: choose decontamination, clean earth, the used time section.
Two, preparation
The Radix Rehmanniae of described weight, Rhizoma Gastrodiae, Lumbricus, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Flos Chrysanthemi, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Semen Plantaginis, the Radix Paeoniae Alba, Radix Saposhnikoviae, Herba Asari, Cortex Cinnamomi, Radix Puerariae, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Ginseng, Poria, the Radix Astragali, Fructus Hordei Germinatus, Semen Platycladi, Radix Rehmanniae Preparata, Massa Medicata Fermentata, Herba Menthae, Herba Schizonepetae, Rhizoma Corydalis, Scorpio, Radix Bupleuri, Semen Persicae, Rhizoma Zingiberis Recens are added to 6 times of water gagings, intense fire decocts boiling 25 minutes, the water that adds again 4 times of amounts, use again slow fire boiling 20 minutes, must take medicinal liquid, will take medicinal liquid and be divided into 4 doses.
Medicine of the present invention has the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, and treatment migraine instant effect, short treating period, do not recur, and cure rate is high.
Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 20 of rabbit, the male and female dual-purpose, body weight 2.3-2.5kg, divide two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 25ml/kg, and normal amount is 15ml/kg, and administering mode is the administration by gavage administration, once a day, serve on 20 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 300 examples for medical treatment.
2, diagnostic criteria
Ictal moderate is to the severe pulsatile headache, and the companion feels sick, vomiting or photophobia.Physical exertion makes the headache aggravation.Outbreak is only light dull pain or sense of discomfort to moderate while starting, and reaches serious throbbing pain or jumping pain after a few minutes to several hours.Approximately 2/3 is a side headache, also can be bilatenal headache, and pain is radiated to cervical region and shoulder sometimes.
3, Therapeutic Method
Select above-mentioned medicament, each serving with 1 dose, every day early, middle and late respectively taking 1 time.Within 14 days, be a course for the treatment of, take continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: clinical symptom disappearance after treatment, the patient recovers normally, observes half a year without the recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and migraine is progressively recovered;
Invalid: clinical partial symptoms disappears or, without change, does not reach improvement standard person.
5, therapeutic outcome
Figure 839367DEST_PATH_IMAGE001
In above-mentioned treatment, by Drug therapy migraineur's 460 examples of the present invention, produce effects 422 examples as a result, obvious effective rate is 91.74%, 28 examples that take a turn for the better, improvement rate is 6.09%, invalid 10 examples, total effective rate is 97.83%.

Claims (3)

1. treat migrainous medicine for one kind, it is characterized in that: it is to be made by the crude drug in the following weight scope:
Radix Rehmanniae 10-30 gram Rhizoma Gastrodiae 8-22 gram Lumbricus 10-20 gram
Flos Carthami 4-12 gram Radix Paeoniae Rubra 10-22 gram Rhizoma Chuanxiong 4-12 gram
Rhizoma Et Radix Notopterygii 8-18 gram Flos Chrysanthemi 10-20 cron gallbladder 4-12 gram
Radix Arnebiae (Radix Lithospermi) 10-20 gram Semen Plantaginis 10-22 gram Radix Paeoniae Alba 10-20 gram
Radix Saposhnikoviae 10-28 gram Herba Asari 2-8 gram Cortex Cinnamomi 3-12 gram
Radix Puerariae 10-20 gram Rhizoma Cyperi 8-12 gram Radix Angelicae Sinensis 4-15 gram
Radix Ginseng 10-20 gram Poria 8-15 gram Radix Astragali 6-22 gram
Fructus Hordei Germinatus 6-18 gram Semen Platycladi 10-20 gram Radix Rehmanniae Preparata 10-22 gram
Massa Medicata Fermentata 5-12 gram Herba Menthae 12-22 gram Herba Schizonepetae 10-20 gram
Rhizoma Corydalis 8-22 gram Scorpio 8-15 gram Radix Bupleuri 8-17 gram
Semen Persicae 8-22 gram Rhizoma Zingiberis Recens 8-14 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Rehmanniae 20 gram Rhizoma Gastrodiae 15 gram Lumbricus 15 grams
Flos Carthami 8 gram Radix Paeoniae Rubra 15 gram Rhizoma Chuanxiong 8 grams
Rhizoma Et Radix Notopterygii 10 gram Flos Chrysanthemi 15 cron gallbladder 8 grams
The Radix Arnebiae (Radix Lithospermi) 15 gram Semen Plantaginis 13 gram Radix Paeoniae Alba 20 grams
Radix Saposhnikoviae 15 gram Herba Asari 6 gram Cortex Cinnamomi 10 grams
Radix Puerariae 15 gram Rhizoma Cyperi 10 gram Radix Angelicae Sinensis 10 grams
The Radix Ginseng 15 gram Poria 9 gram Radix Astragali 13 grams
Fructus Hordei Germinatus 10 gram Semen Platycladi 15 gram Radix Rehmanniae Preparata 15 grams
Massa Medicata Fermentata 10 gram Herba Menthae 15 gram Herba Schizonepetae 15 grams
Rhizoma Corydalis 12 gram Scorpio 10 gram Radix Bupleuri 10 grams
Semen Persicae 10 gram Rhizoma Zingiberis Recens 10 grams.
3. according to the preparation method of claim 1 or 2 described medicine, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
(2) Rhizoma Gastrodiae: Rhizoma Gastrodiae slice is laid on the watch core paper that sprayed water, puts in pot, with slow fire, burn to the paper color sallow, constantly tablet is stirred to the two sides strong yellow for the degree;
(3) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
(4) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(5) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, clean, runs through, and shave, drying, sieve removes chip;
(6) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;
(7) Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;
(8) Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
(9) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(10) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dry;
(11) Semen Plantaginis: choose decontamination, sieve removes spare and empty grain;
(12) Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(13) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(14) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dry;
(15) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, by warm water, infiltrates a moment, and section, dry;
(16) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dry in time;
(17) Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;
(18) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
(19) Radix Ginseng: except removing LU, cutting;
(20) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(21) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(22) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;
(23) Semen Platycladi: choose clean impurity, remove residual shell and plant skin;
(24) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, cut into slices, drying;
(25) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in the heat pot, the cigarette of having waited, pour Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
(26) Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
(27) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;
(28) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(29) Scorpio: clear water floats the matter that desalts, and dry, or the low baking temperature roasting is used;
(30) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
(31) Semen Persicae: remove duricrust impurity, put in the boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
(32) Rhizoma Zingiberis Recens: choose decontamination, clean earth, the used time section;
(2) preparation
The Radix Rehmanniae of described weight, Rhizoma Gastrodiae, Lumbricus, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Flos Chrysanthemi, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Semen Plantaginis, the Radix Paeoniae Alba, Radix Saposhnikoviae, Herba Asari, Cortex Cinnamomi, Radix Puerariae, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Ginseng, Poria, the Radix Astragali, Fructus Hordei Germinatus, Semen Platycladi, Radix Rehmanniae Preparata, Massa Medicata Fermentata, Herba Menthae, Herba Schizonepetae, Rhizoma Corydalis, Scorpio, Radix Bupleuri, Semen Persicae, Rhizoma Zingiberis Recens are added to 6 times of water gagings, intense fire decocts boiling 25 minutes, the water that adds again 4 times of amounts, use again slow fire boiling 20 minutes, must take medicinal liquid, will take medicinal liquid and be divided into 4 doses.
CN2012104166223A 2012-10-28 2012-10-28 Drug for treating migraine and preparation method thereof Expired - Fee Related CN102872443B (en)

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CN103349692B (en) * 2013-05-13 2015-04-01 中国人民解放军第三七一医院 Traditional Chinese medicine preparation for treating migraine and trigeminal neuralgia
CN103751407B (en) * 2013-12-23 2015-07-08 青岛市市立医院 Traditional Chinese medicine for treating exopathogenic cold-wind type prosopalgia
CN106943490A (en) * 2017-04-28 2017-07-14 董早霞 Wind-expelling pain-stopping Huayu Tang

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CN101708315A (en) * 2009-12-04 2010-05-19 卢速江 Chinese medicinal preparation for treating headache and preparation method thereof
CN101850097A (en) * 2010-01-19 2010-10-06 泰一和浦(北京)中医药研究院有限公司 Chinese medicinal composition for treating medial headache and migraine and preparation method thereof
CN102120023A (en) * 2010-01-11 2011-07-13 王继红 Chinese medicinal preparation for treating migraine and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101708315A (en) * 2009-12-04 2010-05-19 卢速江 Chinese medicinal preparation for treating headache and preparation method thereof
CN102120023A (en) * 2010-01-11 2011-07-13 王继红 Chinese medicinal preparation for treating migraine and preparation method thereof
CN101850097A (en) * 2010-01-19 2010-10-06 泰一和浦(北京)中医药研究院有限公司 Chinese medicinal composition for treating medial headache and migraine and preparation method thereof

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