CN103735916B

CN103735916B - A kind of medicine for the treatment of the nephrotic syndrome and preparation method thereof

Info

Publication number: CN103735916B
Application number: CN201410035670.7A
Authority: CN
Inventors: 王莉
Original assignee: 王莉
Priority date: 2014-01-26
Filing date: 2014-01-26
Publication date: 2015-10-21
Anticipated expiration: 2034-01-26
Also published as: CN103735916A

Abstract

The invention discloses a kind of medicine for the treatment of the nephrotic syndrome and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as the Cortex Eucommiae, Ramulus Cinnamomi, the Radix Astragali, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Pseudostellariae, Radix Rehmanniae Preparata, Herba Leonuri, Rhizoma Curculiginises, medicine of the present invention has kidney invigorating and YANG supporting, expelling wind and removing dampness, effect of diuresis eliminating dampness by diuresis, be used for the treatment of nephrotic syndrome instant effect, good effect, have no side effect.

Description

A kind of medicine for the treatment of the nephrotic syndrome and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of the nephrotic syndrome and preparation method thereof, belong to the field of Chinese medicines.

Background technology

The nephrotic syndrome is called for short nephropathy, and be the disease increased based on glomerular basement membrane permeability, can be caused by Different types of etiopathogenises, its clinical special disease is High-grade Proteinuria, hypoproteinemia, hypercholesterolemia and hydrosarca.Primary disease is comparatively common in kidney disease, and treatment not in time, often easily causes renal failure.At present, because Western medicine effectively cannot treat nephropathy, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating nephropathy.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment nephropathy, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating nephropathy.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects the Cortex Eucommiae, Ramulus Cinnamomi, the Radix Astragali, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Pseudostellariae, Radix Rehmanniae Preparata, Herba Leonuri, Rhizoma Curculiginis, Pericarpium Citri Reticulatae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Achyranthis Bidentatae, Fructus Mori, Herba Epimedii, Semen Cuscutae, Radix Et Rhizoma Rhei, Caulis Bambusae In Taenia, the Rhizoma Atractylodis Macrocephalae, Colla Plastri Testudinis, Colla cornus cervi, Polyporus, Fructus Corni, Rhizoma Atractylodis, Radix Puerariae, Semen Plantaginis, Radix Dipsaci, Cortex Moutan medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat kidney palindromia.Wherein select the Cortex Eucommiae be because its nature and flavor sweet micro-pungent, temperature, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, hypertension.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Radix Aconiti Lateralis Preparata is selected to be because its property acrid-sweet flavor, heat, poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Radix Ginseng is selected to be that temperature, enters spleen, lung meridian, have strongly invigorating primordial QI because its nature and flavor are sweet micro-sweet, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Herba Leonuri to be that cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia because its nature and flavor are worked hard, control and Lou have difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, have the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, have tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow the function of liquid, control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Semen Cuscutae to be because its property acrid-sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Colla Plastri Testudinis to be because its property sweet-salty, flat, have YIN nourishing, enrich blood, the function of hemostasis, control deficiency of YIN anemia, consumptive fever hectic fever due to YIN-deficiency, spit blood, epistaxis, dysphoria with smothery sensation is palpitated with fear, lumbago due to renal deficiency, flaccidity of feet and knees, metrorrhagia, leukorrhagia.Select Colla cornus cervi to be because its property sweet-salty, temperature, enters liver, kidney channel, enriches blood, and the function of benefit essence, controls deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.Select Polyporus to be because its property slightly sweet flavor, flat, enter spleen, kidney, urinary bladder channel, have the function of diuresis eliminating dampness by diuresis, control dysuria, edema distension, beriberi, has loose bowels, and drenches, turbid, leukorrhagia.Fructus Corni is selected to be that tepor, enters liver, kidney channel, have invigorating the liver and kidney, arresting seminal emission gas, Gu the function of collapse, controls soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, and seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse because its nature and flavor acid.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Radix Puerariae to be because its nature and flavor are sweet pungent, flat, enter spleen, stomach warp, have yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, cure the wound cold, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, and has loose bowels, dysentery, and abnormal pigmentary deposit on the skin is examined not saturating, hypertension, and angina pectoris is deaf.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Select Radix Dipsaci to be that tepor, enters liver, kidney channel, have invigorating the liver and kidney, reuniting the fractured tendons and bones, and the function of blood circulation regulating, controls aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia because its nature and flavor toil, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swells.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Cortex Eucommiae 5-15 gram of Ramulus Cinnamomi 5-15 gram of Radix Astragali 10-20 gram

Radix Aconiti Lateralis Preparata 5-15 gram of Radix Ginseng 5-15 gram of Radix Pseudostellariae 5-15 gram

Radix Rehmanniae Preparata 5-15 gram of Herba Leonuri 5-15 gram of Rhizoma Curculiginis 5-15 gram

Pericarpium Citri Reticulatae 15-25 gram Rhizoma Anemarrhenae 15-25 gram Radix Ophiopogonis 15-25 gram

Radix Achyranthis Bidentatae 10-20 gram of Fructus Mori 10-20 gram of Herba Epimedii 10-20 gram

Semen Cuscutae 10-20 gram of Radix Et Rhizoma Rhei 10-20 gram of Caulis Bambusae In Taenia 10-20 gram

Rhizoma Atractylodis Macrocephalae 15-25 gram of Colla Plastri Testudinis 15-25 gram of Colla cornus cervi 15-25 gram

Polyporus 15-25 Keshan Fructus Evodiae 15-25 gram of Rhizoma Atractylodis 10-20 gram

Radix Puerariae 10-20 gram of Semen Plantaginis 10-20 gram of Radix Dipsaci 10-20 gram

Cortex Moutan 10-20 gram

Preferable amount is

The Cortex Eucommiae 10 grams of Ramulus Cinnamomi 10 grams of Radixs Astragali 15 grams

Radix Aconiti Lateralis Preparata 10 grams of Radix Ginsengs 10 grams of Radix Pseudostellariaes 10 grams

Radix Rehmanniae Preparata 10 grams of Herba Leonuris 10 grams of Rhizoma Curculiginises 10 grams

Pericarpium Citri Reticulatae 20 grams of Rhizoma Anemarrhenaes 20 grams of Radix Ophiopogonis 20 grams

Radix Achyranthis Bidentatae 15 grams of Fructus Moris 15 grams of Herba Epimedii 15 grams

Semen Cuscutae 15 grams of Radix Et Rhizoma Rhei 15 grams of Caulis Bambusae In Taenia 15 grams

The Rhizoma Atractylodis Macrocephalae 20 grams of Colla Plastri Testudinis 20 grams of Colla cornus cervis 20 grams

The Polyporus 20 Keshan Fructus Evodiae 20 grams of Rhizoma Atractylodis 15 grams

Radix Puerariae 15 grams of Semen Plantaginiss 15 grams of Radix Dipsacis 15 grams

Cortex Moutan 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;

2, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

3, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

4, Radix Aconiti Lateralis Preparata: be soaked in water, pulls out, and section, dries;

5, Radix Ginseng: except removing LU, cutting;

6, Radix Pseudostellariae: extract fibrous root, dry;

7, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

8, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

9, Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

10, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

11, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

12, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

13, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

14, Fructus Mori: wash, picks decontamination, extracts long handle, dries;

15, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

16, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

17, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;

18, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

19, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

20, Colla Plastri Testudinis: get the clean Carapax et Plastrum Testudinis after drift bubble, puts decocting in pot and for several times, decocts to colloid most, go dregs, by repeatedly fried glue, filter and merge, add a little alum powder, leave standstill, the glue of leaching clarification, concentrate with slow fire or add appropriate yellow wine, crystal sugar in paste, in impouring gel groove, take out after making its condensation, be cut into small pieces, dry in the shade;

21, Colla cornus cervi: get crude drug, removing impurity, the used time smashs to pieces or levigation;

22, Polyporus: clean silt particle, soften section, dry;

23, Fructus Corni: clean, except removal core and impurity, dry;

24, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

25, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;

26, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;

27, Radix Dipsaci: clean silt, removing retained root head, runs through rear section and dries, sieve anti-dandruff;

28, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries.

Two, prepare

1, the Cortex Eucommiae of described weight, Ramulus Cinnamomi, the Radix Astragali, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Pseudostellariae, Radix Rehmanniae Preparata, Herba Leonuri, Rhizoma Curculiginis, Pericarpium Citri Reticulatae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Achyranthis Bidentatae, Fructus Mori, Herba Epimedii, Semen Cuscutae, Radix Et Rhizoma Rhei, Caulis Bambusae In Taenia, the Rhizoma Atractylodis Macrocephalae, Polyporus, Fructus Corni, Rhizoma Atractylodis, Radix Puerariae, Semen Plantaginis, Radix Dipsaci, Cortex Moutan medicine are decocted with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 30 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 40 minutes, filter and to obtain second time decoction liquor.

3, by twice decoction liquor mixing, the Colla Plastri Testudinis and the Colla cornus cervi that add described weight are while hot dissolved in decoction medicinal liquid, stir, are divided into 4 doses to take.

Medicine of the present invention has kidney invigorating and YANG supporting, expelling wind and removing dampness, effect of diuresis eliminating dampness by diuresis, and treatment nephropathy instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 187 example for medical treatment.

2, diagnostic criteria

Clinical manifestation

(1) anasarca: start to see eyelid and face, gradually throughout whole body, severe patient can have thoracic cavity, seroperitoneum and scrotum, penis, labia edema;

(2) blood pressure is normal or increase;

(3) oliguria or hematuria can be had.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 10 days, is a course for the treatment of, takes 6 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: the nephrotic syndrome is eliminated, without recurring after observing half a year;

Take a turn for the better: nephropathy symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy nephrotic 187 example of the present invention, effective 180 examples of result, obvious effective rate is 96.26%, and take a turn for the better 5 examples, and improvement rate is 2.67%, and invalid 2 examples, total effective rate is 98.93%.

Claims

1. treat a medicine for the nephrotic syndrome, it is characterized in that: it is made up of the crude drug in following weight range:

Cortex Moutan 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

The Rhizoma Atractylodis Macrocephalae 20 grams of Colla Plastri Testudiniss 20 grams of Colla cornus cervis 20 grams

Cortex Moutan 15 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;

(2) Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

(3) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

(4) Radix Aconiti Lateralis Preparata: be soaked in water, pulls out, and section, dries;

(5) Radix Ginseng: except removing LU, cutting;

(6) Radix Pseudostellariae: extract fibrous root, dry;

(7) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

(8) Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

(9) Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

(10) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(11) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(12) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

(13) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(14) Fructus Mori: wash, picks decontamination, extracts long handle, dries;

(15) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(16) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

(17) Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;

(18) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

(19) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

(20) Colla Plastri Testudinis: get the clean Carapax et Plastrum Testudinis after drift bubble, puts decocting in pot and for several times, decocts to colloid most, go dregs, by repeatedly fried glue, filter and merge, add a little alum powder, leave standstill, the glue of leaching clarification, concentrate with slow fire or add appropriate yellow wine, crystal sugar in paste, in impouring gel groove, take out after making its condensation, be cut into small pieces, dry in the shade;

(21) Colla cornus cervi: get crude drug, removing impurity, the used time smashs to pieces or levigation;

(22) Polyporus: clean silt particle, soften section, dry;

(23) Fructus Corni: clean, except removal core and impurity, dry;

(24) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

(25) Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;

(26) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;

(27) Radix Dipsaci: clean silt, removing retained root head, runs through rear section and dries, sieve anti-dandruff;

(28) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(2) prepare

(1) Cortex Eucommiae of described weight, Ramulus Cinnamomi, the Radix Astragali, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Pseudostellariae, Radix Rehmanniae Preparata, Herba Leonuri, Rhizoma Curculiginis, Pericarpium Citri Reticulatae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Achyranthis Bidentatae, Fructus Mori, Herba Epimedii, Semen Cuscutae, Radix Et Rhizoma Rhei, Caulis Bambusae In Taenia, the Rhizoma Atractylodis Macrocephalae, Polyporus, Fructus Corni, Rhizoma Atractylodis, Radix Puerariae, Semen Plantaginis, Radix Dipsaci, Cortex Moutan medicine are decocted with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 30 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

(2) add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 40 minutes, filter and to obtain second time decoction liquor;

(3) by twice decoction liquor mixing, the Colla Plastri Testudinis and the Colla cornus cervi that add described weight are while hot dissolved in decoction medicinal liquid, stir, are divided into 4 doses to take.