CN103393927B - Medicine for treating climacteric syndrome and preparation method thereof - Google Patents
Medicine for treating climacteric syndrome and preparation method thereof Download PDFInfo
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- CN103393927B CN103393927B CN201310318296.7A CN201310318296A CN103393927B CN 103393927 B CN103393927 B CN 103393927B CN 201310318296 A CN201310318296 A CN 201310318296A CN 103393927 B CN103393927 B CN 103393927B
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Abstract
The invention discloses a medicine for treating climacteric syndrome and a preparation method thereof. The medicine mainly comprises golden cypress, rhizoma anemarrhenae, rhizoma alismatis, poria, glossy privet fruit, radix ophiopogonis, schisandra chinensis and angelica sinensis according to a certain weight ratio. The medicine disclosed by the invention has the functions of nourishing yin and moistening the lung, clearing away the heart fire and relieving restlessness, enriching and adjusting blood, regulating menstruation and relieving pain, and nourishing yin to lessen fire, and has the advantages of rapid and good curative effect and favorable curative rate when being used for treating climacteric syndrome.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of climacteric syndrome and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Climacteric refers to the one section period of women from period of duration to geratic period transition, is the period that ovarian function fails gradually.Start from 40 years old, last 10-20, menopause is important symbol.During this period, because sex hormones secretion amount reduces, there is the syndrome based on autonomic nervous dysfunction, claim climacteric syndrome.Primary disease in malnutrition, spiritual emotional instability and operation, that radiotherapy makes ovarian function lose decrease in estrogen rapid person sickness rate is high, and symptom is also more serious.Because Western medicine effectively cannot treat climacteric syndrome, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of rapid, effective treatment climacteric syndrome.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment climacteric syndrome, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating climacteric syndrome.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Cortex Phellodendri, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, Radix Astragali medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of climacteric syndrome.Cortex Phellodendri is wherein selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria, edema distension, phlegm retention cough with dyspnea, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizzy, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Morindae Officinalis to be because its property acrid-sweet flavor, temperature, enter liver, kidney channel, have kidney-replenishing, strengthening bone and muscle, the function of wind-damp dispelling, controls sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.Radix Arnebiae (Radix Lithospermi) is selected to be because its nature and flavor earnestly, are trembled with fear, entered percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Semen Cuscutae to be because its property acrid-sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Cortex Phellodendri 8-15 grams of Rhizoma Anemarrhenaes 8-15 grams of Rhizoma Alismatis 10-20 grams
Poria 10-20 grams of Fructus Ligustri Lucidi 10-20 grams of Radix Ophiopogonis 10-20 grams
Fructus Schisandrae Chinensis 10-20 grams of Radix Angelicae Sinensis 8-15 grams of Radix Morindae Officinaliss 8-15 grams
Radix Arnebiae (Radix Lithospermi) 10-20 grams of Radix Paeoniae Albas 15-25 grams of Herba Epimedii 8-15 grams
Semen Cuscutae 15-25 grams of Radixs Astragali 8-15 grams
Preferable amount is
Cortex Phellodendri 10 grams of Rhizoma Anemarrhenaes 10 grams of Rhizoma Alismatis 15 grams
Poria 15 grams of Fructus Ligustri Lucidi 15 grams of Radix Ophiopogonis 15 grams
Fructus Schisandrae Chinensis 15 grams of Radix Angelicae Sinensis 10 grams of Radix Morindae Officinaliss 10 grams
Radix Arnebiae (Radix Lithospermi) 15 grams of Radix Paeoniae Albas 20 grams of Herba Epimedii 10 grams
Semen Cuscutae 20 grams of Radixs Astragali 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
2, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
3, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
4, Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
5, Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
6, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
7, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
8, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
9, Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;
10, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
11, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
12, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;
13, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
14, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry.
Two, prepare
1, the Cortex Phellodendri of described weight, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, the Radix Astragali are decocted with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, twice decoction liquor merged, intense fire boils, then uses slow fire boiling 10 minutes, decoction liquor is divided into 4 doses to take.
Medicine of the present invention has nourishing YIN and moistening the lung, and clear away heart-fire relieving restlessness, benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, effect of nourishing YIN to lower pathogenic fire, and treatment climacteric syndrome instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 20ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 300 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
(1) menoxenia: menstrual cycle extends, reduces gradually through amount; Or menstrual cycle shortens, menorrhagia; Or the cycle, menstrual period, through amount do not plan; Or menolipsis suddenly.
(2) paroxysmal hectic fever, perspiration, companioned with headache, dizziness, cardiopalmus, uncomfortable in chest, nauseating etc.
(3) absent-minded, emotional, have a sleepless night, worry too much, the Spirit nerve symptoms of disease such as depressed.
(4) genitals's atrophy in various degree.
(5) mastoptosis, atrophy, frequent micturition, urinary incontinence etc.
(6) osteoporosis, lumbago and backache, easily fracture.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 15 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: climacteric syndrome is eliminated, without recurring after observing half a year;
Take a turn for the better: climacteric syndrome symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy climacteric syndrome Patients with 300 Cases of the present invention, effective 290 examples of result, obvious effective rate is 96.67%, and take a turn for the better 6 examples, and improvement rate is 2%, and invalid 4 examples, total effective rate is 98%.
Claims (3)
1. treat a medicine for climacteric syndrome, it is characterized in that: it is made up of the crude drug in following weight range:
Cortex Phellodendri 8-15 grams of Rhizoma Anemarrhenaes 8-15 grams of Rhizoma Alismatis 10-20 grams
Poria 10-20 grams of Fructus Ligustri Lucidi 10-20 grams of Radix Ophiopogonis 10-20 grams
Fructus Schisandrae Chinensis 10-20 grams of Radix Angelicae Sinensis 8-15 grams of Radix Morindae Officinaliss 8-15 grams
Radix Arnebiae (Radix Lithospermi) 10-20 grams of Radix Paeoniae Albas 15-25 grams of Herba Epimedii 8-15 grams
Semen Cuscutae 15-25 grams of Radixs Astragali 8-15 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Cortex Phellodendri 10 grams of Rhizoma Anemarrhenaes 10 grams of Rhizoma Alismatis 15 grams
Poria 15 grams of Fructus Ligustri Lucidi 15 grams of Radix Ophiopogonis 15 grams
Fructus Schisandrae Chinensis 15 grams of Radix Angelicae Sinensis 10 grams of Radix Morindae Officinaliss 10 grams
Radix Arnebiae (Radix Lithospermi) 15 grams of Radix Paeoniae Albas 20 grams of Herba Epimedii 10 grams
Semen Cuscutae 20 grams of Radixs Astragali 10 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
(2) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
(3) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
(4) Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
(5) Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
(6) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
(7) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(8) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;
(9) Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;
(10) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
(11) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(12) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;
(13) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
(14) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(2) prepare
(1) Cortex Phellodendri of described weight, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, the Radix Astragali are decocted with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;
(3) twice decoction liquor merged, intense fire boils, then uses slow fire boiling 10 minutes, decoction liquor is divided into 4 doses to take.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310318296.7A CN103393927B (en) | 2013-07-26 | 2013-07-26 | Medicine for treating climacteric syndrome and preparation method thereof |
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| CN103393927B true CN103393927B (en) | 2015-02-11 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1735421A (en) * | 2002-12-04 | 2006-02-15 | 余仁生(香港)有限公司 | A kind of medicine for treating climacteric syndrome of women and preparation method thereof |
| CN1876096A (en) * | 2006-04-21 | 2006-12-13 | 韩志强 | Main component of Chinese medicinal capsule for treating climacteric syndrome and preparation method thereof |
| CN102406834A (en) * | 2011-12-05 | 2012-04-11 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating yang deficiency type climacteric syndrome of women |
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2013
- 2013-07-26 CN CN201310318296.7A patent/CN103393927B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1735421A (en) * | 2002-12-04 | 2006-02-15 | 余仁生(香港)有限公司 | A kind of medicine for treating climacteric syndrome of women and preparation method thereof |
| CN1876096A (en) * | 2006-04-21 | 2006-12-13 | 韩志强 | Main component of Chinese medicinal capsule for treating climacteric syndrome and preparation method thereof |
| CN102406834A (en) * | 2011-12-05 | 2012-04-11 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating yang deficiency type climacteric syndrome of women |
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