CN103735792A

CN103735792A - Medicament for treating abnormal menstruation and preparation method for medicament

Info

Publication number: CN103735792A
Application number: CN201410040772.8A
Authority: CN
Inventors: 张怀胜
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-01-28
Filing date: 2014-01-28
Publication date: 2014-04-23
Anticipated expiration: 2034-01-28
Also published as: CN103735792B

Abstract

The invention discloses a medicament for treating abnormal menstruation and a preparation method for the medicament. The medicament is mainly prepared from white peony root, semen cuscutae, yams, fructus lycii, dipsacus asperoids, rhizoma curculiginis, herba epimedii, polygonum multiflorum and the like according to a certain weight ratio. The medicament disclosed by the invention has the functions of breaking and removing blood stasis, moistening dryness and activating blood circulation, can take quick effect on treatment of the abnormal menstruation and has a good treating effect; the abnormal menstruation cannot relapse after being cured.

Description

A kind of medicine for the treatment of menoxenia and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of menoxenia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Menoxenia also claims menoxenia, is a kind of common gynecological disease.Show as the abnormal of menstrual cycle or amount of bleeding, or stomachache and General Symptoms during month premenstrual, menstrual period.The cause of disease may be organic disease or malfunction.At present, because Western medicine cannot effectively be treated menoxenia, and long-term taking Western medicine has more side effect, and therefore, people exist great demand to the Chinese medicine of effective treatment menoxenia.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment menoxenia, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can effectively treat menoxenia.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects the Radix Paeoniae Alba, Semen Cuscutae, Rhizoma Dioscoreae, Fructus Lycii, Radix Dipsaci, Rhizoma Curculiginis, Herba Epimedii, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Semen Persicae, Radix Cyathulae, Herba Leonuri, Caulis Spatholobi, Rhizoma Corydalis, Radix Linderae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of menoxenia.Wherein select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Select Rhizoma Dioscoreae to be because its property bitter but sweet flavor is flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforces the kidney, and the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, and cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Fructus Lycii to be because its nature and flavor are sweet, flat, there is nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, and loses clear.Selecting Radix Dipsaci is that tepor, enters liver, kidney channel, has invigorating the liver and kidney because of its nature and flavor toil, reuniting the fractured tendons and bones, and the function of blood circulation regulating, controls aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer is swollen.Select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, there is the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Selecting Herba Epimedii is that temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Radix Polygoni Multiflori to be because its property bitter but sweet flavor is puckery, tepor, enters liver, kidney channel, has tonifying liver, and kidney tonifying, nourishes blood, the function of dispeling the wind, control hepatic and renal YIN deficiency, sending out must be early white, blood deficiency dizziness, and waist knee joint weakness, muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Radix Paeoniae Rubra to be because its nature and flavor hardship is slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Radix Cyathulae to be because its nature and flavor are flat, the micro-hardship of bitter in the mouth, nontoxic, enter liver, kidney two warps, dispel the wind, dampness removing, stimulates the menstrual flow, the function of invigorating blood circulation, dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen.Select Herba Leonuri to be because its nature and flavor are arduous, cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature, enters the heart, spleen two warps, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulates the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select the Radix Linderae to be because its nature and flavor are pungent, temperature, enters spleen, lung, kidney, urinary bladder channel, have pleasant, dissipating depression of QI, cold expelling, the function of pain relieving, controls QI rising in reverse order chest and abdomen swelling and pain, dyspepsia is discontented, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Paeoniae Alba 10-20 gram of Semen Cuscutae 10-20 Keshan medicine 15-25 gram

Fructus Lycii 5-15 gram of Radix Dipsaci 5-15 gram of Rhizoma Curculiginis 10-20 gram

Herba Epimedii 10-20 gram of Radix Polygoni Multiflori 10-20 gram of Fructus Ligustri Lucidi 15-25 gram

Radix Paeoniae Rubra 10-20 gram of Semen Persicae 10-15 gram of Radix Cyathulae 5-15 gram

Herba Leonuri 5-15 gram of Caulis Spatholobi 5-15 gram of Rhizoma Corydalis 10-20 gram

Radix Linderae 6-12 gram

Preferable amount is

20 grams of 15 grams of Semen Cuscutae of the Radix Paeoniae Alba, 15 Keshan medicines

15 grams of 10 grams of Rhizoma Curculiginises of 10 grams of Radix Dipsacis of Fructus Lycii

20 grams of 15 grams of Fructus Ligustri Lucidi of 15 grams of Radix Polygoni Multiflori of Herba Epimedii

10 grams of 12 grams of Radix Cyathulaes of 15 grams of Semen Persicaes of Radix Paeoniae Rubra

15 grams of 10 grams of Rhizoma Corydalis of 10 grams of Caulis Spatholobis of Herba Leonuri

9 grams of the Radixs Linderae

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Radix Paeoniae Alba: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and section, dries;

2, Semen Cuscutae: sieve and remove impurity, clean, dry;

3, Rhizoma Dioscoreae: choose clean impurity, be soaked in water while softening to Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or dried;

4, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

5, Radix Dipsaci: clean silt, remove impurity, run through rear section and dry, sieve removes chip;

6, Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, put pot interior micro-stir-fry to dry, take out, dry, 100 jin of every Rhizoma Curculiginises, with yellow wine 10-20 jin;

7, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;

8, Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;

9, Fructus Ligustri Lucidi: choose decontamination, clean, dry;

10, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;

11, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

12, Radix Cyathulae: choose decontamination, dry;

13, Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

14, Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

15, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, section;

16, the Radix Linderae: choose decontamination, separately size bar, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, sieve dedust bits.

Two, preparation

1, the Radix Paeoniae Alba of described weight, Semen Cuscutae, Rhizoma Dioscoreae, Fructus Lycii, Radix Dipsaci, Rhizoma Curculiginis, Herba Epimedii, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Semen Persicae, Radix Cyathulae, Herba Leonuri, Caulis Spatholobi, Rhizoma Corydalis, the Radix Linderae are decocted with water to secondary, add for the first time 8 times of amounts of water, intense fire decocts boiling 25 minutes, use again slow fire boiling 35 minutes, obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.

2, will filter for the first time rear medicinal residues and add 6 times of amounts of water, decoct boiling, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time.

3,, by twice decoction liquor mix homogeneously, be divided into 4 doses and take.

Medicine of the present invention has nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and blood circulation promoting and blood stasis dispelling, the effect of regulating menstruation, treatment menoxenia instant effect, short treating period, do not recur.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 269 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation

The disorder that shows as menstrual cycle or amount of bleeding has following several situation

(1) irregular metrorrhagia

Comprise: menorrhagia or persistent period are long.

(2) dysfunctional uterine bleeding

Refer to that interior external genitalia is without significant organic pathological changes, and by the caused metrorrhagia of endocrine regulation unbalance of system.Be modal one in menoxenia, be common in adolescence and climacteric.Be divided into ovulation property and anovulatory two classes, approximately 85% case belongs to anovulatory bleeding.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, each 1 dose, take every day 2 times, within 15 days, be a course for the treatment of, take continuously 2 courses for the treatment of.

4, efficacy assessment standard

Effective: menoxenia is eliminated, observe after half a year without recurrence;

Take a turn for the better: menoxenia symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

Figure 2014100407728100002DEST_PATH_IMAGE001

In above-mentioned treatment, by Drug therapy menoxenia patient of the present invention 269 examples, effective 256 examples of result, obvious effective rate is 95.17%, 10 examples that take a turn for the better, and improvement rate is 3.72%, invalid 3 examples, total effective rate is 98.89%.

Claims

1. a medicine for the treatment of menoxenia, is characterized in that: it is to be made by the crude drug in following weight range:

Radix Linderae 6-12 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is

9 grams of the Radixs Linderae.

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Paeoniae Alba: choose decontamination, separately size, is soaked in water to eighty per cant saturating, pulls out, and section, dries;

(2) Semen Cuscutae: sieve and remove impurity, clean, dry;

(3) Rhizoma Dioscoreae: choose clean impurity, be soaked in water while softening to Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or dried;

(4) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(5) Radix Dipsaci: clean silt, remove impurity, run through rear section and dry, sieve removes chip;

(6) Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, put pot interior micro-stir-fry to dry, take out, dry, 100 jin of every Rhizoma Curculiginises, with yellow wine 10-20 jin;

(7) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;

(8) Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;

(9) Fructus Ligustri Lucidi: choose decontamination, clean, dry;

(10) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;

(11) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(12) Radix Cyathulae: choose decontamination, dry;

(13) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

(14) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

(15) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, section;

(16) Radix Linderae: choose decontamination, separately size bar, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, sieve dedust bits;

(2) preparation

(1) Radix Paeoniae Alba of described weight, Semen Cuscutae, Rhizoma Dioscoreae, Fructus Lycii, Radix Dipsaci, Rhizoma Curculiginis, Herba Epimedii, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Semen Persicae, Radix Cyathulae, Herba Leonuri, Caulis Spatholobi, Rhizoma Corydalis, the Radix Linderae are decocted with water to secondary, add for the first time 8 times of amounts of water, intense fire decocts boiling 25 minutes, use again slow fire boiling 35 minutes, obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;

(2) will filter for the first time rear medicinal residues and add 6 times of amounts of water, decoct boiling, then use slow fire boiling 30 minutes, filter to obtain decoction liquor for the second time;

(3), by twice decoction liquor mix homogeneously, be divided into 4 doses and take.