CN104056194A - Medicine for treating polycythemia vera and preparation method thereof - Google Patents
Medicine for treating polycythemia vera and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating polycythemia vera and a preparation method thereof. The medicine for treating polycythemia vera is prepared by Chinese gentian, mulberry, Chinese garlic, spine date seed, cremastra, tree peony bark, red sage root, spatholobus stem, magnolia cortex, dendrobium, chrysanthemum and scorpion according to certain weight ratio. The medicine for treating polycythemia vera has the functions of clearing heat and detoxifying, and cooling the blood to resolve stagnation, and can be used for treating polycythemia vera with fast effectiveness, good curative effect and no recurrence.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of polycythemia vera and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Polycythemia vera is the not bright hematopoietic stem cell clone property disease of a kind of reason, belongs to myeloproliferative diseases category.Clinically take RBC number and capacity and significantly increase as feature, occur the performance due to plethora and high viscid mass formed by blood stasis, often accompany splenomegaly.Polycythemia vera insidious onset, makes slow progress, and late period, various conversions can occur.The remarkable purple of skin and mucosa, especially with buccal, lip, tongue, ear, nose, cervical region and limb end for very.Eye binding film is significantly congested.Approximately 2/3 patient often has hepatomegaly, is mostly slight.Later stage can cause liver cirrhosis.Patient has splenomegaly more, mostly more obvious, and infarction of spleen can occur, and causes perisplenitis.At present, because Western medicine cannot effectively be treated polycythemia vera, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment polycythemia vera.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment polycythemia vera, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat polycythemia vera.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Gentianae, Fructus Mori, Bulbus Allii Macrostemonis, Semen Ziziphi Spinosae, Pseudobulbus cremastrae seu pleiones, Cortex Moutan, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Dendrobii, Flos Chrysanthemi, Scorpio, Indigo Naturalis, Cornu Bubali, Fructus Trichosanthis, Radix Sanguisorbae, Squama Manis, Herba Euphorbiae Helioscopiae, Rhizoma Curcumae, Caulis Polygoni Multiflori, Oletum Trogopterori, Fructus Ligustri Lucidi, Scolopendra, Aloe, Herba Artemisiae Scopariae, honeysuckle to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of polycythemia vera.Wherein select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, there is eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, there is tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows the function of liquid, controls hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Bulbus Allii Macrostemonis to be because its nature and flavor are arduous, temperature, enters meridian of Hand-YANG MING, regulates the flow of vital energy, and the chest stuffiness relieving, activates yang, and the function of eliminating stagnation is controlled the thorough back of the body of obstruction of qi in the chest and cardialgia, and gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Select Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, enter the heart, spleen, liver, gallbladder meridian, there is nourishing the liver, mind calming, calms the nerves, and the function of arresting sweating, controls restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select Pseudobulbus cremastrae seu pleiones to be because its nature and flavor are sweet micro-pungent, cold, enter liver, spleen channel, there is detumescence, eliminating stagnation, reduces phlegm, and the function of removing toxic substances is controlled carbuncle furuncle swollen, scrofula, sore throat swells and ache, Serpentis, worm, mad dog wound.Select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature, enters the heart, spleen two warps, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Semen Trichosanthis to be because its nature and flavor are sweet, cold, return lung, stomach, large intestine channel, there is moistening the lung and resolving phlegm, the function of laxation relieving constipation, controls cough caused by dryness expectorant glutinous, dryness of the intestine constipation.Selecting Cortex Magnoliae Officinalis is that temperature, enters spleen, stomach, large intestine channel, has warming middle-JIAO because of its nature and flavor toil, the therapeutic method to keep the adverse QI flowing downwards, and dampness, the function of expectorant, controls breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, there is the stomach reinforcing of promoting the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, it is dark that the moon is hindered order.Select Flos Chrysanthemi to be because its nature and flavor sweetness and bitterness is cool, enter lung, Liver Channel, has dispelling wind, the heat that disappears, and improving eyesight, the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, controls convulsion with spasms ， epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer is swollen.Select Indigo Naturalis to be because its nature and flavor are salty, cold, enter liver, lung, stomach warp, there is heat clearing away, removing heat from blood, the function of removing toxic substances, controls epidemic febrile disease intenseness of heat, and macule is spitted blood, is spat blood, little Jing Epilepsy, skin ulcer is swollen, erysipelas, snake bite and insect sting.Select Cornu Bubali to be because its nature and flavor hardship is salty, tremble with fear, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Fructus Trichosanthis to be because sweet, the micro-hardship of its nature and flavor is cold, return lung, stomach, large intestine channel, have clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the function of moisturizing laxation, controls cough due to lung-heat, and the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, acute appendicitis, constipation.Select Radix Sanguisorbae to be because its nature and flavor picric acid is cold, enter liver, large intestine channel, have cooling blood for hemostasis, the function of heat-clearing and toxic substances removing, controls haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, controls carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Herba Euphorbiae Helioscopiae to be because its nature and flavor are arduous, cool, poisonous, enter large and small intestinal, spleen, has row water, expectorant, parasite killing, and the function of removing toxic substances, controls edematous asthma, and phlegm retention is breathed with cough, malaria, scrofula, tinea skin ulcer, Tuberculous flaccidity pipe, osteomyelitis.Select Rhizoma Curcumae to be because its nature and flavor acrid, bitter, warm.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma.Select Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste is flat, enter the heart, Liver Channel, nourish heart, calm the nerves, dredging collateral, the function of dispeling the wind, controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Selecting Oletum Trogopterori is that temperature, enters liver, spleen channel because of its property bitter but sweet flavor, and the raw function with there being promoting the circulation of blood pain relieving, controls all pains of trusted subordinate's vim and vigour, women's amenorrhea, and postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, fry with hemostasis, controls metrorrhagia, menorrhagia, and leucorrhea with bloody discharge is without cease.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Scolopendra to be because its nature and flavor are pungent, temperature, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, counteracting toxic substances, the function of eliminating stagnation, controls apoplexy ， Jing Epilepsy, tetanus, pertussis, scrofula, tuberculosis ， mass in the abdomen tumor piece, sore swollen toxin, tinea corporis, bald in vain, anal fistula, scalds.Select Aloe to be because its nature and flavor are bitter, cold, enter liver, the heart, spleen channel, there is heat clearing away, relieving constipation, the function of parasite killing, controls constipation with heat retention, women's amenorrhea, little Jing Epilepsy, infantile malnutrition with fever malnutrition due to parasitic infestation, tinea skin ulcer, hemorrhoid complicated by anal fistula, atrophic rhinitis, scrofula.Select Herba Artemisiae Scopariae to be because its nature and flavor toil is cool, enter liver, spleen, urinary bladder channel, have the function of clearing away heat-damp and promoting diuresis, control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Gentianae 5-10 gram of Fructus Mori 15-25 gram of Bulbus Allii Macrostemonis 5-10 gram
5-15 gram of Cortex Moutan 5-10 gram of Semen Ziziphi Spinosae 5-15 Keshan Rhizoma sagittariae sagittifoliae
Radix Salviae Miltiorrhizae 5-15 gram of Caulis Spatholobi 15-25 gram of Cortex Magnoliae Officinalis 10-14 gram
Herba Dendrobii 5-15 gram of Flos Chrysanthemi 5-10 gram of Scorpio 2-10 gram
Indigo Naturalis 5-10 gram of Cornu Bubali 10-20 gram of Fructus Trichosanthis 5-10 gram
Radix Sanguisorbae 10-14 gram of Squama Manis 3-9 gram of Herba Euphorbiae Helioscopiae 5-15 gram
Rhizoma Curcumae 10-14 gram of Caulis Polygoni Multiflori 10-20 gram of Oletum Trogopterori 2-6 gram
Fructus Ligustri Lucidi 5-15 gram of Scolopendra 2-6 gram of Aloe 5-10 gram
Herba Artemisiae Scopariae 10-20 gram of Flos Lonicerae 10-14 gram.
Preferable amount is
8 grams of 20 grams of Bulbus Allii Macrostemonis of 8 grams of Fructus Moris of Radix Gentianae
8 grams of 10 grams of Cortex Moutans of Semen Ziziphi Spinosae 10 Keshan Rhizoma sagittariae sagittifoliae
12 grams of 20 grams of Cortex Magnoliae Officinalis of 10 grams of Caulis Spatholobis of Radix Salviae Miltiorrhizae
5 grams of 8 grams of Scorpios of 10 grams of Flos Chrysanthemis of Herba Dendrobii
8 grams of 15 grams of Fructus Trichosanthis of 8 grams of Cornu Bubalis of Indigo Naturalis
10 grams of 6 grams of Herba Euphorbiae Helioscopiae of 12 grams of Squama Maniss of Radix Sanguisorbae
4 grams of 15 grams of Oletum Trogopteroris of 12 grams of Caulis Polygoni Multiflori of Rhizoma Curcumae
8 grams of 4 grams of Aloes of 10 grams of Scolopendras of Fructus Ligustri Lucidi
12 grams of 15 grams of Flos Loniceraes of Herba Artemisiae Scopariae.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
2, Fructus Mori: wash, choose decontamination, extract long handle, dry;
3, Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
4, Semen Ziziphi Spinosae: former medicine is put into bamboo square-bottomed bamboo basket, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;
5, Pseudobulbus cremastrae seu pleiones: eliminate fibrous root, clean, clear water soaks 2-4 hour, and taking-up runs through, and section, dries;
6, Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
7, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
8, Caulis Spatholobi: water runs through, section, or steam soft after while hot section, dry;
9, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding, dries;
10, Herba Dendrobii: get dry Herba Dendrobii, saturating with blister to eighty per cant, stewing profit, removes undesirable root and black branch, and cutting, removes thin film, dries;
11, Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
12, Scorpio: clear water floats the matter that desalts, dries;
13, Indigo Naturalis: choose decontamination, cross square-bottomed bamboo basket;
14, Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;
15, Fructus Trichosanthis: get crude drug, remove impurity and fruit stem, clean, flatten, shredding or fritter, dry;
16, Radix Sanguisorbae: choose decontamination, wash, slightly soak, run through, be cut into sheet, dry;
17, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
18, Herba Euphorbiae Helioscopiae: get crude drug, remove undesirable root, impurity, cleans, slightly moistens, and cutting is dry;
19, Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping, cleans, and slightly soaks, and takes out, runs through, shave, and dry, sieve removes chip;
20, Caulis Polygoni Multiflori: clear water is cleaned, slightly soaks, and pulls out, and after running through, cutting, dries;
21, Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
22, Fructus Ligustri Lucidi: choose decontamination, clean, dry;
23, Scolopendra: wipe away only, remove cephalopodium, cut off use;
24, Aloe: choose decontamination, hack into fritter;
25, Herba Artemisiae Scopariae: sieve, choose decontamination, remove undesirable root, pulverize, remove spare after sieve;
26, Flos Lonicerae: sieve removes silt, chooses clean impurity.
Two, preparation
1, the Radix Gentianae of described weight, Fructus Mori, Bulbus Allii Macrostemonis, Semen Ziziphi Spinosae, Pseudobulbus cremastrae seu pleiones, Cortex Moutan, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Dendrobii, Flos Chrysanthemi, Scorpio, Indigo Naturalis, Cornu Bubali, Fructus Trichosanthis, Radix Sanguisorbae, Squama Manis, Herba Euphorbiae Helioscopiae, Rhizoma Curcumae, Caulis Polygoni Multiflori, Oletum Trogopterori, Fructus Ligustri Lucidi, Scolopendra, Aloe, Herba Artemisiae Scopariae, honeysuckle are decocted with water twice, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, will filter for the first time rear medicinal residues and add 6 times of amounts of water, and decoct boiling, then within 30 minutes, obtain decoction liquor for the second time with slow fire boiling.
3, twice decoction liquor mixed and be get final product, decoction liquor being divided into 6 doses and taking.
Medicine of the present invention has heat clearing away, removing toxic substances, and removing heat from blood, and blood, the effect of repercussive, treatment polycythemia vera instant effect, short treating period, do not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.3kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 30 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation:
(1) blood vessel and neurological symptom
Because blood volume increases, blood viscosity increases, and causes whole body each internal organs slow blood flow and tissue ischemia.Can there is in early days headache, dizzy, tired, tinnitus, dim eyesight, the similar neurosis symptom such as forgetful.Severe one diplopia, blurred vision.
(2) thrombosis, thromboembolism or phlebitis
Significantly slow when blood flow, during especially with thrombocytosis, can there be thrombosis and infarction.Thrombosis is most commonly in extremity, mesentery, brain and coronary vasodilator.When serious, there is paralysis symptom.
(3) bleeding tendency
Due to reasons such as the congestion of blood vessel, inner film injury and platelet the 3rd factor reduce, clot retraction is bad, can there is bleeding tendency.Be most commonly in skin ecchymosis, gingival hemorrhage, visible wound or postoperative hemorrhage are more than sometimes.
(4) skin pruritus and peptic ulcer
Primary disease basophilic granulocyte also increases, and basophilic granule is rich in histamine, and a large amount of release stimulates gastric gland parietal cell, can cause peptic ulcer, and irritating skin has obvious pruritus.
(5) hyperuricemia
Can produce secondary gout, renal calculus and renal function injury.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively taking 1 time, 7 days was a course for the treatment of, took continuously 7 courses for the treatment of.
4, efficacy assessment standard
Effective: polycythemia vera recovery from illness, observe after half a year without recurrence;
Take a turn for the better: polycythemia vera symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy Patients with Polycythemia Vera 30 examples of the present invention, effective 25 examples of result, obvious effective rate is 83.33%, 3 examples that take a turn for the better, and improvement rate is 10%, invalid 2 examples, total effective rate is 93.33%.
Claims (3)
1. a medicine for the treatment of polycythemia vera, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Gentianae 5-10 gram of Fructus Mori 15-25 gram of Bulbus Allii Macrostemonis 5-10 gram
5-15 gram of Cortex Moutan 5-10 gram of Semen Ziziphi Spinosae 5-15 Keshan Rhizoma sagittariae sagittifoliae
Radix Salviae Miltiorrhizae 5-15 gram of Caulis Spatholobi 15-25 gram of Cortex Magnoliae Officinalis 10-14 gram
Herba Dendrobii 5-15 gram of Flos Chrysanthemi 5-10 gram of Scorpio 2-10 gram
Indigo Naturalis 5-10 gram of Cornu Bubali 10-20 gram of Fructus Trichosanthis 5-10 gram
Radix Sanguisorbae 10-14 gram of Squama Manis 3-9 gram of Herba Euphorbiae Helioscopiae 5-15 gram
Rhizoma Curcumae 10-14 gram of Caulis Polygoni Multiflori 10-20 gram of Oletum Trogopterori 2-6 gram
Fructus Ligustri Lucidi 5-15 gram of Scolopendra 2-6 gram of Aloe 5-10 gram
Herba Artemisiae Scopariae 10-20 gram of Flos Lonicerae 10-14 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
8 grams of 20 grams of Bulbus Allii Macrostemonis of 8 grams of Fructus Moris of Radix Gentianae
8 grams of 10 grams of Cortex Moutans of Semen Ziziphi Spinosae 10 Keshan Rhizoma sagittariae sagittifoliae
12 grams of 20 grams of Cortex Magnoliae Officinalis of 10 grams of Caulis Spatholobis of Radix Salviae Miltiorrhizae
5 grams of 8 grams of Scorpios of 10 grams of Flos Chrysanthemis of Herba Dendrobii
8 grams of 15 grams of Fructus Trichosanthis of 8 grams of Cornu Bubalis of Indigo Naturalis
10 grams of 6 grams of Herba Euphorbiae Helioscopiae of 12 grams of Squama Maniss of Radix Sanguisorbae
4 grams of 15 grams of Oletum Trogopteroris of 12 grams of Caulis Polygoni Multiflori of Rhizoma Curcumae
8 grams of 4 grams of Aloes of 10 grams of Scolopendras of Fructus Ligustri Lucidi
12 grams of 15 grams of Flos Loniceraes of Herba Artemisiae Scopariae.
3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(2) Fructus Mori: wash, choose decontamination, extract long handle, dry;
(3) Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
(4) Semen Ziziphi Spinosae: former medicine is put into bamboo square-bottomed bamboo basket, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;
(5) Pseudobulbus cremastrae seu pleiones: eliminate fibrous root, clean, clear water soaks 2-4 hour, and taking-up runs through, and section, dries;
(6) Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
(7) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(8) Caulis Spatholobi: water runs through, section, or steam soft after while hot section, dry;
(9) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding, dries;
(10) Herba Dendrobii: get dry Herba Dendrobii, saturating with blister to eighty per cant, stewing profit, removes undesirable root and black branch, and cutting, removes thin film, dries;
(11) Flos Chrysanthemi: choose clean leaf stalk, anthocaulus and spare impurity;
(12) Scorpio: clear water floats the matter that desalts, dries;
(13) Indigo Naturalis: choose decontamination, cross square-bottomed bamboo basket;
(14) Cornu Bubali: rive, with hot-water soak, pull out, pound sheet, dries;
(15) Fructus Trichosanthis: get crude drug, remove impurity and fruit stem, clean, flatten, shredding or fritter, dry;
(16) Radix Sanguisorbae: choose decontamination, wash, slightly soak, run through, be cut into sheet, dry;
(17) Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
(18) Herba Euphorbiae Helioscopiae: get crude drug, remove undesirable root, impurity, cleans, slightly moistens, and cutting is dry;
(19) Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping, cleans, and slightly soaks, and takes out, runs through, shave, and dry, sieve removes chip;
(20) Caulis Polygoni Multiflori: clear water is cleaned, slightly soaks, and pulls out, and after running through, cutting, dries;
(21) Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;
(22) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(23) Scolopendra: wipe away only, remove cephalopodium, cut off use;
(24) Aloe: choose decontamination, hack into fritter;
(25) Herba Artemisiae Scopariae: sieve, choose decontamination, remove undesirable root, pulverize, remove spare after sieve;
(26) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(2) preparation
(1) Radix Gentianae of described weight, Fructus Mori, Bulbus Allii Macrostemonis, Semen Ziziphi Spinosae, Pseudobulbus cremastrae seu pleiones, Cortex Moutan, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Dendrobii, Flos Chrysanthemi, Scorpio, Indigo Naturalis, Cornu Bubali, Fructus Trichosanthis, Radix Sanguisorbae, Squama Manis, Herba Euphorbiae Helioscopiae, Rhizoma Curcumae, Caulis Polygoni Multiflori, Oletum Trogopterori, Fructus Ligustri Lucidi, Scolopendra, Aloe, Herba Artemisiae Scopariae, honeysuckle are decocted with water twice, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;
(2) will filter for the first time rear medicinal residues and add 6 times of amounts of water, and decoct boiling, then within 30 minutes, obtain decoction liquor for the second time with slow fire boiling;
(3) twice decoction liquor mixed and be get final product.
Priority Applications (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258222A (en) * | 2014-10-20 | 2015-01-07 | 侯云珍 | Traditional Chinese medicine composition for treating polycythemia vera |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009230A1 (en) * | 2009-07-24 | 2011-01-27 | 河北以岭医药研究院有限公司 | Pharmaceutical for treating idiopathic edema and preparation methods thereof |
| CN102283997A (en) * | 2011-07-28 | 2011-12-21 | 北京中科血康血液病医学研究院 | Medicament for treating polycythemia vera, thrombocytosis and aplastic anemia |
| CN102631518A (en) * | 2012-04-01 | 2012-08-15 | 湖南创新中医药研究有限公司 | New medicament for treating leukemia |
-
2014
- 2014-06-25 CN CN201410286376.3A patent/CN104056194A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009230A1 (en) * | 2009-07-24 | 2011-01-27 | 河北以岭医药研究院有限公司 | Pharmaceutical for treating idiopathic edema and preparation methods thereof |
| CN102283997A (en) * | 2011-07-28 | 2011-12-21 | 北京中科血康血液病医学研究院 | Medicament for treating polycythemia vera, thrombocytosis and aplastic anemia |
| CN102631518A (en) * | 2012-04-01 | 2012-08-15 | 湖南创新中医药研究有限公司 | New medicament for treating leukemia |
Non-Patent Citations (2)
| Title |
|---|
| 庞翠莲等: "《中医辨证施治血液系统疑难病》", 28 February 2007, 科学技术文献出版社 * |
| 马东梅等: "真性红细胞增多症的中医治疗纂要", 《中医药学刊》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258222A (en) * | 2014-10-20 | 2015-01-07 | 侯云珍 | Traditional Chinese medicine composition for treating polycythemia vera |
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