CN103721223B - A kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof - Google Patents

A kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof Download PDF

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CN103721223B
CN103721223B CN201310678576.9A CN201310678576A CN103721223B CN 103721223 B CN103721223 B CN 103721223B CN 201310678576 A CN201310678576 A CN 201310678576A CN 103721223 B CN103721223 B CN 103721223B
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herba
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CN103721223A (en
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郑明立
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郑明立
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Abstract

The invention discloses a kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Concha Ostreae, Fluoritum, Herba Ecliptae, Carapax Trionycis, Folium Mori, Flos Celosiae Cristatae, Herba Agrimoniaes, the present invention has removing heat from blood, hemostasis, dissipating blood stasis, pain relieving, lowering the adverse flow of QI, the function in warm uterus, is used for the treatment of dysfunctional uterine hemorrhage instant effect, good effect, does not recur.

Description

A kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Dysfunctional uterine bleeding is called for short dysfunctional uterine hemorrhage or anovulatory dysfunctional uterine hemorrhage, is caused, instead of caused by gestation, endometrial tumors, infection or hematopathy etc. by neuroendocrine disorders.Often betide adolescence, be anovulatory dysfunctional metrorrhagia, also known as pubertal dysfunctional uterine bleeding.At present, because Western medicine effectively cannot treat dysfunctional uterine hemorrhage, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating dysfunctional uterine hemorrhage.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment dysfunctional uterine hemorrhage, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating dysfunctional uterine hemorrhage.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Concha Ostreae selected by medicine of the present invention, Fluoritum, Herba Ecliptae, Carapax Trionycis, Folium Mori, Flos Celosiae Cristatae, Herba Agrimoniae, Endoconcha Sepiae, Radix Patriniae heterophyllae, Exocarpium Litchi, Herba Cirsii, the Radix Pulsatillae, Fructus Mori, Os Draconis, Radix Notoginseng, Radix Ginseng Rubra, Radix Rumicis Japonici, Herba Chenopodii Hybridi, Herba Capsellae, Semen Ziziphi Spinosae, Flos Chrysanthemi Indici, Nodus Nelumbinis Rhizomatis, Terra Flava Usta, Semen Benincasae, Rhizoma Zingiberis Recens, Fructus Lycii, Rhizoma Paridis, Fructus Rosae Laevigatae, Cortex Ailanthi, Fructus Jujubae, Herba Pyrolae, Radix Angelicae Pubescentis, Fructus Schisandrae Chinensis, Herba Schizonepetae, Colla cornus cervi, Semen Cuscutae, Radix Codonopsis medicine carries out combining, each efficacy of drugs is made by these drug regimens to produce synergism, thus effectively can treat the recurrence of dysfunctional uterine hemorrhage.Wherein select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduce phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Fluoritum to be that temperature, enters the heart, Liver Channel, have relieving palpitation, calm the nerves, lowering the adverse flow of QI because its nature and flavor are sweet, the function in warm uterus, control asthenia palpitation with fear, cough with dyspnea, women's sea of blood deficiency and coldness is infertile.Select Herba Ecliptae to be because its nature and flavor picric acid, cool, enter liver, kidney channel, have removing heat from blood, hemostasis, the kidney invigorating, the function of tonifying YIN, controls haematemesis, hemoptysis, epistaxis, and hematuria is had blood in stool, dysentery, and knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly , mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select Flos Celosiae Cristatae to be because its nature and flavor are sweet, cool, enter liver channel of foot-Jueyin, have removing heat from blood, the function of hemostasis, control anal fistula hematochezia, red white dysentery, spit blood, hemoptysis, stranguria with blood, women's metrorrhagia, leucorrhea with red and white discharge.Select Herba Agrimoniae to be because its nature and flavor toil, flat, enter lung, liver, spleen channel, have hemostasis, the function of stomach invigorating, controls spitting of blood, and spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.Select Endoconcha Sepiae to be that tepor, enters liver, kidney channel, have dehumidifying, antacid because its nature and flavor are salty, hemostasis, the function of sore, treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.Select Radix Patriniae heterophyllae to be because its nature and flavor are pungent, warm in nature, enter the heart, liver two warp, control pyrexial malaria, women's metrorrhagia, leucorrhea with red and white discharge, traumatic injury.Exocarpium Litchi is selected to be because it controls dysentery, metrorrhagia, eczema.Select Herba Cirsii to be because its nature and flavor are pungent, temperature, enter spleen, stomach two warp, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, rapid digestion of food, the function of parasite killing, controls vomiting and diarrhoea, trusted subordinate's distending pain, furuncle toxic swelling skin ulcer, and poisonous insect flood dragon hinders.The Radix Pulsatillae is selected to be that cold, enter large intestine, liver, stomach warp, have clearing away heat and cooling blood, the function of removing toxic substances, controls toxic-heat and blood stasis, pyrexial malaria cold and heat, epistaxis, internal hemorrhoid with bleeding because its nature and flavor are bitter.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, have tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow the function of liquid, control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Os Draconis to be because its property sweet-puckery flavor, flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, control frightened Epilepsy demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select Radix Ginseng Rubra to be because sweet, the micro-hardship of its nature and flavor, temperature, returns spleen, lung, heart channel, has strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and the function of nourishing qi to stop, controls weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis, heart failure, cardiogenic shock.Select Radix Rumicis Japonici to be because its nature and flavor are bitter, cold, slightly poisonous, enter meridian of Hand-SHAO YIN, have heat clearing away, relieving constipation, diuretic, hemostasis, the function of parasite killing, controls constipation due to dry stool, stranguria with turbid discharge, jaundice, spits blood, hemorrhoidal hamorrhage, dysfunctional uterine hemorrhage, tinea alba, scabies, carbuncle, traumatic injury.Herba Chenopodii Hybridi is selected to be that flat, have hemostasis, the function of invigorating blood circulation, controls menoxenia, metrorrhagia because its nature and flavor are sweet, spitting of blood, epistaxis, hematuria, sore and toxic.Select Herba Capsellae to be because its nature and flavor are sweet, flat, enter meridian of Foot-JUE YIN, have and spleen, diuretic, hemostasis, the function of improving eyesight, controls dysentery, edema, gonorrhea, chyluria, spits blood, has blood in stool, metrorrhagia, menorrhagia, conjunctival congestion and pain of eye.Semen Ziziphi Spinosae is selected to be that flat, enter the heart, spleen, liver, gallbladder meridian, have nourishing the liver, mind calming, calm the nerves, the function of arresting sweating, controls restlessness of asrhenia type and insomnia because its nature and flavor are sweet, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Flos Chrysanthemi Indici is selected to be that cool, enter lung, Liver Channel, have wind and heat dispersing, the function of subduing swelling and detoxicating, controls anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters because its nature and flavor toil.Select Nodus Nelumbinis Rhizomatis to be because its property sweet-puckery flavor, flat, few the moon of starting with, foot sun is bright, and JUE YIN meridian, has hemostasis, and the function of dissipating blood stasis, controls hemoptysis, and spit blood, epistaxis, hematuria, has blood in stool, dysentery, metrorrhagia.Select Terra Flava Usta be because its nature and flavor pungent, temperature, enter spleen, stomach warp, have warming middle-JIAO dampness, preventing or arresting vomiting hemostasis function, stopping vomiting tells regurgitation, and stomachache is had loose bowels, haematemesis, epistaxis, have blood in stool, hematuria, forepart pregnant women malignant histocytosis, bleeding not during menses, carbuncle ulcer.Select Semen Benincasae to be that cool, enter lung, intestine and small intestine, urinary bladder channel, have diuretic, expectorant, heat clearing away, the function of removing toxic substances, harness the river swollen, distension, beriberi, gonorrhea, expectorant is shouted, cough with asthma because its property slightly sweet flavor, summer-heat is unhappy, quenches one's thirst, dysentery, carbuncle, anal fistula, and separates ichthyotoxin, alcoholism.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Fructus Lycii is selected to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, seminal emission.Select Rhizoma Paridis to be because its nature and flavor toil, cold, poisonous, enter the heart, Liver Channel, have heat-clearing and toxic substances removing, antiasthmatic-antitussive, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, and infantile convulsion is twitched, snake bite and insect sting.Select Fructus Rosae Laevigatae to be that flat, enter kidney, bladder, large intestine channel, have reinforcing the kidney and controlling nocturnal emission, the function of reducing urination and antidiarrheal, controls spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, and the deficiency of the lung is breathed with cough, spontaneous sweating because its nature and flavor are sour and astringent, bone leaks leukorrhagia.Cortex Ailanthi is selected to be that cold, return large intestine, stomach, Liver Channel, have heat clearing and damp drying, the function of astringent therapy leukorrhagia stopping, antidiarrheal, hemostasis, controls leucorrhea with red and white discharge, and damp-heat dysentery rushes down chronic dysentery outward, has blood in stool, metrorrhagia because its nature and flavor are bitter, puckery.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Herba Pyrolae to be because its nature and flavor sweetness and bitterness, temperature, enters liver, kidney two warp, has tonify deficiency, kidney tonifying, expelling wind and removing dampness, the function of promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage.Select Radix Angelicae Pubescentis to be that temperature, enters kidney, urinary bladder channel, dispel the wind because its nature and flavor are worked hard, victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select Colla cornus cervi to be because its property sweet-salty, temperature, enters liver, kidney channel, enriches blood, and the function of benefit essence, controls deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.Select Semen Cuscutae to be because its property acrid-sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Concha Ostreae 15-25 gram of Fluoritum 15-25 gram of Herba Ecliptae 15-25 gram
Carapax Trionycis 10-20 gram of Folium Mori 10-20 gram of Flos Celosiae Cristatae 10-20 gram
Herba Agrimoniae 10-20 gram of Endoconcha Sepiae 10-20 gram of Radix Patriniae heterophyllae 10-20 gram
Exocarpium Litchi 10-20 gram of Herba Cirsii 5-15 gram of Radix Pulsatillae 5-15 gram
Fructus Mori 5-15 cron bone 5-15 gram of Radix Notoginseng 5-15 gram
Radix Ginseng Rubra 5-15 gram of Radix Rumicis Japonici 5-15 gram of Herba Chenopodii Hybridi 5-15 gram
Herba Capsellae 15-25 gram of Semen Ziziphi Spinosae 15-25 gram of Flos Chrysanthemi Indici 15-25 gram
Nodus Nelumbinis Rhizomatis 15-25 gram of Terra Flava Usta 15-25 gram of Semen Benincasae 15-25 gram
Rhizoma Zingiberis Recens 15-25 gram of Fructus Lycii 15-25 gram of Rhizoma Paridis 15-25 gram
Fructus Rosae Laevigatae 10-20 gram of Cortex Ailanthi 10-20 gram of Fructus Jujubae 10-20 gram
Herba Pyrolae 15-25 gram of Radix Angelicae Pubescentis 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Herba Schizonepetae 5-15 gram of Colla cornus cervi 5-15 gram of Semen Cuscutae 5-15 gram
Radix Codonopsis 10-20 gram
Preferable amount is
Concha Ostreae 20 grams of Fluoritum 20 grams of Herba Ecliptaes 20 grams
Carapax Trionycis 15 grams of Folium Mori 15 grams of Flos Celosiae Cristataes 15 grams
Herba Agrimoniae 15 grams of Endoconcha Sepiaes 15 grams of Radix Patriniae heterophyllaes 15 grams
Exocarpium Litchi 15 grams of Herba Cirsiis 10 grams of Radix Pulsatillaes 10 grams
Fructus Mori 10 cron bone 10 grams of Radix Notoginseng 10 grams
Radix Ginseng Rubra 10 grams of Radix Rumicis Japonicis 10 grams of Herba Chenopodii Hybridis 10 grams
Herba Capsellae 20 grams of Semen Ziziphi Spinosaes 20 grams of Flos Chrysanthemi Indicis 20 grams
Nodus Nelumbinis Rhizomatis 20 grams of Terra Flava Ustas 20 grams of Semen Benincasaes 20 grams
Rhizoma Zingiberis Recens 20 grams of Fructus Lycii 20 grams of Rhizoma Paridis 20 grams
15 grams, Fructus Rosae Laevigatae 15 grams of Cortex Ailanthis 15 grams of Fructus Jujubaes
Herba Pyrolae 20 grams of Radix Angelicae Pubescentiss 20 grams of Fructus Schisandrae Chinensis 20 grams
Herba Schizonepetae 10 grams of Colla cornus cervis 10 grams of Semen Cuscutae 10 grams
Radix Codonopsis 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Concha Ostreae: clean, dry, pulverize use;
2, Fluoritum: clean earth, be pounded fritter;
3, Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
4, Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
5, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
6, Flos Celosiae Cristatae: pick clean impurity, removing stem and seed, be cut into small pieces;
7, Herba Agrimoniae: removing impurity undesirable root, cleans, runs through, cut off, dry;
8, Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;
9, Radix Patriniae heterophyllae: autumn excavates, removes stem Seedling and earth, dries;
10, Exocarpium Litchi: pick clean impurity, dry;
11, Herba Cirsii: pick clean impurity, remove root, washing runs through, tangent plane dries;
12, the Radix Pulsatillae: pick clean impurity, cleans, runs through rear section, dry;
13, Fructus Mori: wash, picks decontamination, extracts long handle, dries;
14, Os Draconis: outwash earth, smash;
15, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
16, Radix Ginseng Rubra: get crude drug, runs through, shave, dry;
17, Radix Rumicis Japonici: the 8-9 month gets, and picks decontamination, dries;
18, Herba Chenopodii Hybridi: the 6-8 month gathers, chopping, dries;
19, Herba Capsellae: the 3-5 month gathers, cleans, dries;
20, Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, is pulled out by Semen Ziziphi Spinosae, dries;
21, Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;
22, Nodus Nelumbinis Rhizomatis: get clean Nodus Nelumbinis Rhizomatis and put that to fry to outside in pot be black, innerly slightly spills clear water in strong yellow, takes out, drying;
23, Terra Flava Usta: removing impurity, breaks into fragment;
24, Semen Benincasae: pick clean impurity, the used time smashs to pieces;
25, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
26, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
27, Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;
28, Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
29, Cortex Ailanthi: removing rough bark, impurity, cleans, runs through, shredding or block, and dry, sieve removes chip;
30, Fructus Jujubae: pick clean impurity, dry;
31, Herba Pyrolae: pick decontamination, sieve removes silt, cleans, slightly moistens, chop up, dry;
32, Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;
33, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
34, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
35, Colla cornus cervi: get crude drug, removing impurity, the used time smashs to pieces or levigation;
36, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
37, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry.
Two, prepare
1, by the Concha Ostreae of described weight, Fluoritum, Herba Ecliptae, Carapax Trionycis, Folium Mori, Flos Celosiae Cristatae, Herba Agrimoniae, Endoconcha Sepiae, Radix Patriniae heterophyllae, Exocarpium Litchi, Herba Cirsii, the Radix Pulsatillae, Fructus Mori, Os Draconis, Radix Notoginseng, Radix Ginseng Rubra, Radix Rumicis Japonici, Herba Chenopodii Hybridi, Herba Capsellae, Semen Ziziphi Spinosae, Flos Chrysanthemi Indici, Nodus Nelumbinis Rhizomatis, Terra Flava Usta, Semen Benincasae, Rhizoma Zingiberis Recens, Fructus Lycii, Rhizoma Paridis, Fructus Rosae Laevigatae, Cortex Ailanthi, Fructus Jujubae, Herba Pyrolae, Radix Angelicae Pubescentis, Fructus Schisandrae Chinensis, Herba Schizonepetae, Colla cornus cervi, Semen Cuscutae, Radix Codonopsis medicine decocts with water secondary, add water 8 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 35 minutes, filter and to obtain second time decoction liquor.
3,6 doses are divided into take twice decoction liquor mixing.
Medicine of the present invention has removing heat from blood, hemostasis, dissipating blood stasis, analgesic therapy, lowering the adverse flow of QI, the effect in warm uterus, and treatment dysfunctional uterine hemorrhage instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 221 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
(1) at random metrorrhagia blood volume time many time few, or to increase suddenly.Amenorrhea time elder, amount of bleeding is many, and the sustainable several months is more than, time stream time only;
(2) health check-up edeoscopy is normal, or the slight increase in bilateral ovaries symmetry ground;
(3) basal body temperature is unipolar type;
(4) severe loss of blood can cause anemia, and severe patient can occur dizziness, has palpitation, breathes hard, weak, the phenomenon such as edema, inappetence;
(5) hormonosis is discharged, distending pain of the breast, lower abdomen falling inflation, excited etc.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: dysfunctional uterine hemorrhage is eliminated, without recurring after observing half a year;
Take a turn for the better: dysfunctional uterine hemorrhage symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy functional uterine bleeding 221 example of the present invention, effective 210 examples of result, obvious effective rate is 95.02%, and take a turn for the better 7 examples, and improvement rate is 3.17%, and invalid 4 examples, total effective rate is 98.19%.

Claims (3)

1. treat a medicine for dysfunctional uterine hemorrhage, it is characterized in that: it is made up of the crude drug in following weight range:
Concha Ostreae 15-25 gram of Fluoritum 15-25 gram of Herba Ecliptae 15-25 gram
Carapax Trionycis 10-20 gram of Folium Mori 10-20 gram of Flos Celosiae Cristatae 10-20 gram
Herba Agrimoniae 10-20 gram of Endoconcha Sepiae 10-20 gram of Radix Patriniae heterophyllae 10-20 gram
Exocarpium Litchi 10-20 gram of Herba Cirsii 5-15 gram of Radix Pulsatillae 5-15 gram
Fructus Mori 5-15 cron bone 5-15 gram of Radix Notoginseng 5-15 gram
Radix Ginseng Rubra 5-15 gram of Radix Rumicis Japonici 5-15 gram of Herba Chenopodii Hybridi 5-15 gram
Herba Capsellae 15-25 gram of Semen Ziziphi Spinosae 15-25 gram of Flos Chrysanthemi Indici 15-25 gram
Nodus Nelumbinis Rhizomatis 15-25 gram of Terra Flava Usta 15-25 gram of Semen Benincasae 15-25 gram
Rhizoma Zingiberis Recens 15-25 gram of Fructus Lycii 15-25 gram of Rhizoma Paridis 15-25 gram
Fructus Rosae Laevigatae 10-20 gram of Cortex Ailanthi 10-20 gram of Fructus Jujubae 10-20 gram
Herba Pyrolae 15-25 gram of Radix Angelicae Pubescentis 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Herba Schizonepetae 5-15 gram of Colla cornus cervi 5-15 gram of Semen Cuscutae 5-15 gram
Radix Codonopsis 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Concha Ostreae 20 grams of Fluoritum 20 grams of Herba Ecliptaes 20 grams
Carapax Trionycis 15 grams of Folium Mori 15 grams of Flos Celosiae Cristataes 15 grams
Herba Agrimoniae 15 grams of Endoconcha Sepiaes 15 grams of Radix Patriniae heterophyllaes 15 grams
Exocarpium Litchi 15 grams of Herba Cirsiis 10 grams of Radix Pulsatillaes 10 grams
Fructus Mori 10 cron bone 10 grams of Radix Notoginseng 10 grams
Radix Ginseng Rubra 10 grams of Radix Rumicis Japonicis 10 grams of Herba Chenopodii Hybridis 10 grams
Herba Capsellae 20 grams of Semen Ziziphi Spinosaes 20 grams of Flos Chrysanthemi Indicis 20 grams
Nodus Nelumbinis Rhizomatis 20 grams of Terra Flava Ustas 20 grams of Semen Benincasaes 20 grams
Rhizoma Zingiberis Recens 20 grams of Fructus Lycii 20 grams of Rhizoma Paridis 20 grams
15 grams, Fructus Rosae Laevigatae 15 grams of Cortex Ailanthis 15 grams of Fructus Jujubaes
Herba Pyrolae 20 grams of Radix Angelicae Pubescentiss 20 grams of Fructus Schisandrae Chinensis 20 grams
Herba Schizonepetae 10 grams of Colla cornus cervis 10 grams of Semen Cuscutae 10 grams
Radix Codonopsis 15 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Concha Ostreae: clean, dry, pulverize use;
(2) Fluoritum: clean earth, be pounded fritter;
(3) Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
(4) Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
(5) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
(6) Flos Celosiae Cristatae: pick clean impurity, removing stem and seed, be cut into small pieces;
(7) Herba Agrimoniae: removing impurity undesirable root, cleans, runs through, cut off, dry;
(8) Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;
(9) Radix Patriniae heterophyllae: autumn excavates, removes stem Seedling and earth, dries;
(10) Exocarpium Litchi: pick clean impurity, dry;
(11) Herba Cirsii: pick clean impurity, remove root, washing runs through, tangent plane dries;
(12) Radix Pulsatillae: pick clean impurity, cleans, runs through rear section, dry;
(13) Fructus Mori: wash, picks decontamination, extracts long handle, dries;
(14) Os Draconis: outwash earth, smash;
(15) Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
(16) Radix Ginseng Rubra: get crude drug, runs through, shave, dry;
(17) Radix Rumicis Japonici: the 8-9 month gets, and picks decontamination, dries;
(18) Herba Chenopodii Hybridi: the 6-8 month gathers, chopping, dries;
(19) Herba Capsellae: the 3-5 month gathers, cleans, dries;
(20) Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, is pulled out by Semen Ziziphi Spinosae, dries;
(21) Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;
(22) Nodus Nelumbinis Rhizomatis: get clean Nodus Nelumbinis Rhizomatis and put that to fry to outside in pot be black, innerly slightly spills clear water in strong yellow, takes out, drying;
(23) Terra Flava Usta: removing impurity, breaks into fragment;
(24) Semen Benincasae: pick clean impurity, the used time smashs to pieces;
(25) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
(26) Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
(27) Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;
(28) Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
(29) Cortex Ailanthi: removing rough bark, impurity, cleans, runs through, shredding or block, and dry, sieve removes chip;
(30) Fructus Jujubae: pick clean impurity, dry;
(31) Herba Pyrolae: pick decontamination, sieve removes silt, cleans, slightly moistens, chop up, dry;
(32) Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;
(33) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(34) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(35) Colla cornus cervi: get crude drug, removing impurity, the used time smashs to pieces or levigation;
(36) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
(37) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(2) prepare
(1) by the Concha Ostreae of described weight, Fluoritum, Herba Ecliptae, Carapax Trionycis, Folium Mori, Flos Celosiae Cristatae, Herba Agrimoniae, Endoconcha Sepiae, Radix Patriniae heterophyllae, Exocarpium Litchi, Herba Cirsii, the Radix Pulsatillae, Fructus Mori, Os Draconis, Radix Notoginseng, Radix Ginseng Rubra, Radix Rumicis Japonici, Herba Chenopodii Hybridi, Herba Capsellae, Semen Ziziphi Spinosae, Flos Chrysanthemi Indici, Nodus Nelumbinis Rhizomatis, Terra Flava Usta, Semen Benincasae, Rhizoma Zingiberis Recens, Fructus Lycii, Rhizoma Paridis, Fructus Rosae Laevigatae, Cortex Ailanthi, Fructus Jujubae, Herba Pyrolae, Radix Angelicae Pubescentis, Fructus Schisandrae Chinensis, Herba Schizonepetae, Colla cornus cervi, Semen Cuscutae, Radix Codonopsis medicine decocts with water secondary, add water 8 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,
(2) add water the medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 35 minutes, filter and to obtain second time decoction liquor;
(3) 6 doses are divided into take twice decoction liquor mixing.
CN201310678576.9A 2013-12-14 2013-12-14 A kind of medicine for the treatment of dysfunctional uterine hemorrhage and preparation method thereof Expired - Fee Related CN103721223B (en)

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