CN103638463B - Medicine for treating menopause and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating menopause and a preparation method of the medicine. The medicine is mainly prepared from verbena, longan pulp, moutan bark, peach seed, fructus aurantii immaturus, epimedium, radix codonopsis, raspberry, herba lycopi, Chinese rose and other medicines in a certain weight ratio. The medicine has the functions of tonifying middle-jiao and qi, activating blood and promoting circulation of body fluid, regulating menstruation to relieve pain, is quick in response and good in curative effect when used for treating menopause, and does not have toxic or side effect.

Description

A kind ofly treat medicine of woman's amenorrhea and preparation method thereof

Technical field

The present invention relates to and a kind ofly treat medicine of woman's amenorrhea and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Woman's amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause, menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Such differentiation is artificial to a great extent, because the Fundamentals causing former and secondary amenorrhea may be identical sometimes.But when providing the clue of the cause of disease and prognosis, this division is valuable, such as most birth defect, comprises the abnormal development of ovary or Seedling Le Shi tissue, the amenorrhea caused is put into primary amenorrhea, and secondary amenorrhea majority is caused by acquired disease.At present, western medicine woman amenorrhea poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand in the Chinese medicine of people to effectively treatment woman amenorrhea.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment woman amenorrhea, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating woman's amenorrhea.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Herba Verbenae, Arillus Longan, Cortex Moutan, Semen Persicae, Fructus Aurantii Immaturus, Herba Epimedii, Radix Codonopsis, Fructus Rubi, Herba Lycopi, Flos Rosae Chinensis, Cortex Magnoliae Officinalis, Eupolyphaga Seu Steleophaga, Herba Taxilli, Radix Asparagi, Semen sojae atricolor, Rhizoma Cibotii, Rhizoma Curcumae, Fructus Leonuri, Rhizoma Cyperi, Fructus Jujubae, Folium Photiniae (Folium Photiniae serrulatae), Pericarpium Granati, Rhizoma Curculiginis, Herba Leonuri, Fructus Trichosanthis, Flos Campsis, Cornu Cervi Degelatinatum, Radix Clematidis, Fluoritum, Fructus Schisandrae Chinensis, Bombyx mori L. medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating woman amenorrhea.Herba Verbenae is wherein selected to be that cool, enter liver, spleen channel, have heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, the function of inducing diuresis to remove edema, controls fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, amenorrhea ， mass in the abdomen, carbuncle sore tumefacting virus ulcerative gingivitis because its nature and flavor are bitter.Select Arillus Longan to be because its nature and flavor are sweet, temperature, enter the heart, spleen channel, have heart-spleen boosting, fill blood, the function of calming the nerves, controls virtual work thin and weak, insomnia, forgetful, palpitation with fear, severe palpitation.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, have dispelling the stagnated QI, loose painful abdominal mass, rush down expectorant, the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Select Fructus Rubi to be because its nature and flavor are sweet, acid, flat, enter liver, kidney two warp, have invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, the function of improving eyesight, controls sexual impotence, and seminal emission, frequency of micturition, incontinence of urine, asthenia, order is dark.Herba Lycopi is selected to be that tepor, enters liver, spleen channel, invigorate blood circulation, the function of row water, controls amenorrhea ， mass in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, carbuncle because its nature and flavor toil.Flos Rosae Chinensis is selected to be that temperature, enter Liver Channel, have promoting blood flow to regulate menstruation, the function of subduing swelling and detoxicating, controls menoxenia, menalgia, traumatic injury, and blood stasis swells and ache, swollen ulcer drug because its nature and flavor are sweet.Select Cortex Magnoliae Officinalis to be because its nature and flavor toil, temperature, enter spleen, stomach, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Eupolyphaga Seu Steleophaga is selected to be salty because of its nature and flavor, cold, slightly poisonous.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness, cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select Semen sojae atricolor to be because its nature and flavor are sweet, flat, enter spleen, kidney channel, invigorate blood circulation, diuretic, dispel the wind, the function of removing toxic substances, swelling of harnessing the river is full, pathogenic wind-toxic beriberi, jaundice clonic spasm of the muscle, puerperal puerperal tetanus, locked mouth, carbuncle sore tumefacting virus; Separate poison of drug.Select Rhizoma Cibotii to be because its property bitter but sweet flavor, temperature, enters liver, kidney channel, has invigorating the liver and kidney, and except rheumatism, strong waist foot, the function in sharp joint, controls back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, loses and drowns, frequent micturition, seminal emission, leucorrhea.Rhizoma Curcumae is selected to be because its nature and flavor acrid, bitter, warm.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma.Select Fructus Leonuri to be that enter heart born of the same parents, Liver Channel, have promoting blood flow to regulate menstruation, the function of wind and heat dispersing, controls menoxenia, metrorrhagia leukorrhagia, and postnatal blood stasis is had a pain because its nature and flavor are sweet pungent, cool, liver-heat is had a headache, conjunctival congestion and swelling pain, or raw nebula film.Rhizoma Cyperi is selected to be because the pungent micro-hard work of its nature and flavor, flat, enter liver, tri-jiao channel, resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Folium Photiniae (Folium Photiniae serrulatae) is selected to be that flat, enter liver, kidney channel, dispel the wind, dredging collateral, the function of kidney tonifying, controls migratory arthralgia, aching pain in waist and back, flaccidity of the lower limbs of suffering from a deficiency of the kidney, migraine, rubella because its nature and flavor are worked hard.Select Pericarpium Granati to be because its nature and flavor are sour and astringent, temperature, poisonous, enter large intestine, kidney channel, have astringing intestine to stop diarrhea, hemostasis, the function of anthelmintic, controls chronic diarrhea, and chronic dysentery is had blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.Select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, have the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Select Herba Leonuri to be that cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia because its nature and flavor are worked hard, control and Lou have difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Fructus Trichosanthis to be because sweet, the micro-hardship of its nature and flavor, cold, return lung, stomach, large intestine channel, have clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize the function of laxation, control cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, acute appendicitis, constipation.Flos Campsis is selected to be because its nature and flavor acid, cold, enter Liver Channel, have the function of removing heat from blood blood stasis removing, control amenorrhea due to stagnation of blood ， mass in the abdomen, heat in blood pruritus due to wind pathogen, rosacea.Select Cornu Cervi Degelatinatum to be because its nature and flavor are salty, temperature, enter liver, kidney channel, have tonify deficiency, supporing yang function, controls insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, have wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Fluoritum to be that temperature, enters the heart, Liver Channel, have relieving palpitation, calm the nerves, lowering the adverse flow of QI because its nature and flavor are sweet, the function in warm uterus, control asthenia palpitation with fear, cough with dyspnea, women's sea of blood deficiency and coldness is infertile.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid.Select Bombyx mori L. to be that return liver, spleen channel, have expelling wind and removing dampness, the function of analgesic therapy of invigorating blood circulation, dispelling the wind and dampness pathogens arthralgia pain, joint is unsuccessful, waist foot cold type of pain, rubella pruritus because its nature and flavor are sweet, pungent, warm, wind syndrome of head is had a headache, marginal blepharitis eye.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Herba Verbenae 5-15 gram of Arillus Longan 5-15 gram of Cortex Moutan 5-15 gram

Semen Persicae 5-15 gram of Fructus Aurantii Immaturus 15-25 gram of Herba Epimedii 15-25 gram

Radix Codonopsis 10-20 gram of Fructus Rubi 10-20 gram of Herba Lycopi 10-20 gram

Flos Rosae Chinensis 8-15 gram Cortex Magnoliae Officinalis 8-15 gram Eupolyphaga Seu Steleophaga 8-15 gram

Herba Taxilli 10-20 gram of Radix Asparagi 25-35 gram of Semen sojae atricolor 5-15 gram

Rhizoma Cibotii 3-9 gram of Rhizoma Curcumae 5-15 gram of Fructus Leonuri 15-25 gram

Rhizoma Cyperi 5-15 gram of Fructus Jujubae 5-15 gram of Folium Photiniae (Folium Photiniae serrulatae) 5-15 gram

Pericarpium Granati 10-20 gram of Rhizoma Curculiginis 3-9 gram of Herba Leonuri 3-9 gram

Fructus Trichosanthis 6-12 gram of Flos Campsis 5-15 gram of Cornu Cervi Degelatinatum 5-15 gram

Radix Clematidis 10-20 gram of Fluoritum 25-35 gram of Fructus Schisandrae Chinensis 5-15 gram

Bombyx mori L. 5-15 gram

Preferable amount is

Herba Verbenae 10 grams of Arillus Longans 10 grams of Cortex Moutans 10 grams

Semen Persicae 10 grams of Fructus Aurantii Immaturuss 20 grams of Herba Epimedii 20 grams

Radix Codonopsis 15 grams of Fructus Rubies 15 grams of Herba Lycopi 15 grams

Flos Rosae Chinensis 10 grams of Cortex Magnoliae Officinalis 10 grams of Eupolyphaga Seu Steleophagas 10 grams

Herba Taxilli 15 grams of Radix Asparagi 30 grams of Semen sojae atricolor 10 grams

Rhizoma Cibotii 6 grams of Rhizoma Curcumae 10 grams of Fructus Leonuris 20 grams

Rhizoma Cyperi 10 grams of Fructus Jujubaes 10 grams of Folium Photiniae (Folium Photiniae serrulatae)s 10 grams

Pericarpium Granati 15 grams of Rhizoma Curculiginises 6 grams of Herba Leonuris 6 grams

Fructus Trichosanthis 9 grams of Flos Campsiss 10 grams of Cornu Cervi Degelatinatums 10 grams

Radix Clematidis 15 grams of Fluoritum 30 grams of Fructus Schisandrae Chinensis 10 grams

Bombyx mori L. 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Herba Verbenae: pick clean impurity, cleans, softens cutting, dry;

2, Arillus Longan: get crude drug, removing impurity;

3, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

4, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

5, Fructus Aurantii Immaturus: pick clean impurity, be soaked in water to eighty per cant thoroughly, pull out, profit, to interior without hard-core, cut into slices, is dried;

6, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

7, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

8, Fructus Rubi: sieve dedust bits, pick clean impurity, remove handle;

9, Herba Lycopi: pick decontamination, removing undesirable root, water spray slightly moistens, and cutting is dried;

10, Flos Rosae Chinensis: summer, autumn gather semi-open flower, dry, or dry with low baking temperature;

11, Cortex Magnoliae Officinalis: get Rhizoma Zingiberis Recens section and decoct soup, add clean Cortex Magnoliae Officinalis, well-done altogether with ginger decoction, treat that soup exhausts, take out, cut into slices in time, dry, every Cortex Magnoliae Officinalis 100 jin, with 10 jin, Rhizoma Zingiberis Recens;

12, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

13, Herba Taxilli: wash, runs through, and cutting is dried;

14, Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;

15, Semen sojae atricolor: pick clean impurity, dry;

16, Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and pick clean Rhizoma Cibotii, fry to heaving and showing buff with high heat, take out, screen out sand, after wind dries in the air, hits or scraping Huang floss hair;

17, Rhizoma Curcumae: get crude drug, removing impurity, size stepping, cleans, and slightly soaks, and takes out, runs through, shave, dry, and sieve removes chip;

18, Fructus Leonuri: extract Herb during fruit maturation, dries, and lays fruit, picks debranching leaf, well sifted impurity;

19, Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;

20, Fructus Jujubae: pick clean impurity, dry;

21, Folium Photiniae (Folium Photiniae serrulatae): clean, micro-profit, shredding is dried;

22, Pericarpium Granati: pick decontamination, removes residual interior flesh and son, and clean, stripping and slicing, dries;

23, Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

24, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

25, Fructus Trichosanthis: get crude drug, removing impurity and fruit stem, clean, and flattens, shredding or fritter, dry;

26, Flos Campsis: 7-9 gathers between the month, selects fine day and takes just open flower, dry;

27, Cornu Cervi Degelatinatum: pick decontamination, hacks into fritter;

28, Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

29, Fluoritum: clean earth, be pounded fritter;

30, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;

31, Bombyx mori L.: removing impurity, sieve dedust bits.

Two, prepare

1, the Herba Verbenae of described weight, Arillus Longan, Cortex Moutan, Semen Persicae, Fructus Aurantii Immaturus, Herba Epimedii, Radix Codonopsis, Fructus Rubi, Herba Lycopi, Flos Rosae Chinensis, Cortex Magnoliae Officinalis, Eupolyphaga Seu Steleophaga, Herba Taxilli, Radix Asparagi, Semen sojae atricolor, Rhizoma Cibotii, Rhizoma Curcumae, Fructus Leonuri, Rhizoma Cyperi, Fructus Jujubae, Folium Photiniae (Folium Photiniae serrulatae), Pericarpium Granati, Rhizoma Curculiginis, Herba Leonuri, Fructus Trichosanthis, Flos Campsis, Cornu Cervi Degelatinatum, Radix Clematidis, Fluoritum, Fructus Schisandrae Chinensis, Bombyx mori L. medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 6 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into by medicinal liquid 4 doses to take.

Medicine of the present invention has invigorating the spleen and replenishing QI, and the function of invigorate blood circulation row water, menstruction regulating and pain relieving, is used for the treatment of woman's amenorrhea, short treating period, instant effect, has no side effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy woman of the present invention amenorrhea

1, physical data

Accept woman's amenorrhea patients totally 234 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation has ovarian amenorrhea, pituitary amenorrhea, maincenter and hypothalamic amenorrhea.

(1) ovarian amenorrhea: 1. Turners syndrome: A.16 after year, still menolipsis is risen; B. of short and small stature, secondary sex characteristics dysplasia, webbed neck, shield breast, the cubitus valgus; C. High gonadotropic hormone, low sex gland hormones; D. karyotype is 45, XO; 46, XX/45, XO; 45, XO/47, XXX.2. congenital gonad development is bad: normally, secondary sex characteristics is grown roughly normal for karyotype and height.Remaining same Turner ' s syndrome.3. premature ovarian failure: A.40 menopause before year; B. High gonadotropic hormone and low sex gland hormones; C. about about 20% has chromosome chromosome abnormalities; D. about 20% with other autoimmune diseasees; E. in pathologic finding prompting ovary without follicle or only there is few primordial follicle; F. laparoscopy is shown in ovarian atrophy; G. the medical history of iatrogenic damage ovary is had; H. stimulate reactionless to endogenous and exogenous gonadotrophin; I. Clomphid test, in the 5th day cycle, oral Clomphid 50 ~ 100mg, 1 time/d, totally 5 days.Serum FSH was surveyed respectively in the 3rd day and 10 days cycle, as the 10th day FSH value >20U/L, prompting ovarian hypofunction.4. syndrome is resisted: former of A. or secondary amenorrhea; B. High gonadotropic hormone and low sex gland hormones; C. volume primordial follicle and immaturity follicle is had in pathologic finding prompting ovary; D. laparoscopy is shown in that ovarian size is normal, but without growing follicle and ovulation vestige; E. stimulate reactionless to endogenous and exogenous gonadotrophin.5. polycystic ovarian syndrome: clinical manifestation has hypomenorrhea, amenorrhea, infertile chronic anovulation phenomenon as seen; The excessive androgen blood such as hirsutism, acne and acanthosis nigricans are had to levy phenomenon; Fat.

(2) pituitary amenorrhea: 1. pituitary tumor and hyperprolactinemia: the visible amenorrhea of clinical manifestation or menoxenia; Lactogenic; As pituitary tumor can cause more greatly headache and visual disorder; As can pulsatile headache be had for empty sella syndrome; Get rid of the hyperprolactinemia caused of taking medicine.2. pituitary function exhaustion: clinical manifestation has the medical history of postpartum hemorrhage or hypophysis operation as seen; Become thin, weak, fear of cold, pale, puerperal without galactopoiesis, asexual wish, without follicular development, reproductive tract atrophy; Check have the low and hypothyroidism of sex hormone level and low symptom, the sign of adrenal function.

(3) maincenter and hypothalamic amenorrhea: 1. single gonadotropin releasing hormone is low: A. primary amenorrhea, follicle exists but aplasia; B. the patient had has secondary sex characteristics dysplasia in various degree; C.Kallmann ' s patient accompanies anosmia; D.FSH, LH, E2 are all low; 5. GnRH treatment is responded; 6. the KAL genetic flaw of X chromosome (Xp22.3).2. functional hypothalamic amenorrhea: A. amenorrhea or irregular menstruation; B. be common in adolescence or young woman, have more go on a diet, psychentonia, strenuous exercise and irregular life cycle; C. how thin and weak build is; D.TSH level is normal, T3 and T4 is lower; E.FSH and LH is on the low side or close to normal, E2 level is on the low side; F. ultrasonic examination prompting ovary normal size, multiple little follicle is dispersed in distribution, and medullary substance is reflective not to be strengthened.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: woman's amenorrhea transference cure, observe half a year without bounce-back person;

Take a turn for the better: woman's amenorrhea symptom is obviously improved, and body constitution progressively strengthens;

Invalid: woman's amenorrhea symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy woman amenorrhea patients 234 example of the present invention, effective 222 examples of result, obvious effective rate is 94.87%, and take a turn for the better 9 examples, and improvement rate is 3.85%, and invalid 3 examples, total effective rate is 98.72%.

Claims (3)

1. treat a medicine for woman's amenorrhea, it is characterized in that: it is made up of the crude drug in following weight range:

Herba Verbenae 5-15 gram of Arillus Longan 5-15 gram of Cortex Moutan 5-15 gram

Semen Persicae 5-15 gram of Fructus Aurantii Immaturus 15-25 gram of Herba Epimedii 15-25 gram

Radix Codonopsis 10-20 gram of Fructus Rubi 10-20 gram of Herba Lycopi 10-20 gram

Flos Rosae Chinensis 8-15 gram Cortex Magnoliae Officinalis 8-15 gram Eupolyphaga Seu Steleophaga 8-15 gram

Herba Taxilli 10-20 gram of Radix Asparagi 25-35 gram of Semen sojae atricolor 5-15 gram

Rhizoma Cibotii 3-9 gram of Rhizoma Curcumae 5-15 gram of Fructus Leonuri 15-25 gram

Rhizoma Cyperi 5-15 gram of Fructus Jujubae 5-15 gram of Folium Photiniae (Folium Photiniae serrulatae) 5-15 gram

Pericarpium Granati 10-20 gram of Rhizoma Curculiginis 3-9 gram of Herba Leonuri 3-9 gram

Fructus Trichosanthis 6-12 gram of Flos Campsis 5-15 gram of Cornu Cervi Degelatinatum 5-15 gram

Radix Clematidis 10-20 gram of Fluoritum 25-35 gram of Fructus Schisandrae Chinensis 5-15 gram

Bombyx mori L. 5-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Herba Verbenae 10 grams of Arillus Longans 10 grams of Cortex Moutans 10 grams

Semen Persicae 10 grams of Fructus Aurantii Immaturuss 20 grams of Herba Epimedii 20 grams

Radix Codonopsis 15 grams of Fructus Rubies 15 grams of Herba Lycopi 15 grams

Flos Rosae Chinensis 10 grams of Cortex Magnoliae Officinalis 10 grams of Eupolyphaga Seu Steleophagas 10 grams

Herba Taxilli 15 grams of Radix Asparagi 30 grams of Semen sojae atricolor 10 grams

Rhizoma Cibotii 6 grams of Rhizoma Curcumae 10 grams of Fructus Leonuris 20 grams

Rhizoma Cyperi 10 grams of Fructus Jujubaes 10 grams of Folium Photiniae (Folium Photiniae serrulatae)s 10 grams

Pericarpium Granati 15 grams of Rhizoma Curculiginises 6 grams of Herba Leonuris 6 grams

Fructus Trichosanthis 9 grams of Flos Campsiss 10 grams of Cornu Cervi Degelatinatums 10 grams

Radix Clematidis 15 grams of Fluoritum 30 grams of Fructus Schisandrae Chinensis 10 grams

Bombyx mori L. 10 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Herba Verbenae: pick clean impurity, cleans, softens cutting, dry;

(2) Arillus Longan: get crude drug, removing impurity;

(3) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(4) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(5) Fructus Aurantii Immaturus: pick clean impurity, be soaked in water to eighty per cant thoroughly, pull out, profit, to interior without hard-core, cut into slices, is dried;

(6) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(7) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(8) Fructus Rubi: sieve dedust bits, pick clean impurity, remove handle;

(9) Herba Lycopi: pick decontamination, removing undesirable root, water spray slightly moistens, and cutting is dried;

(10) Flos Rosae Chinensis: summer, autumn gather semi-open flower, dry, or dry with low baking temperature;

(11) Cortex Magnoliae Officinalis: get Rhizoma Zingiberis Recens section and decoct soup, add clean Cortex Magnoliae Officinalis, well-done altogether with ginger decoction, treat that soup exhausts, take out, cut into slices in time, dry, every Cortex Magnoliae Officinalis 100 jin, with 10 jin, Rhizoma Zingiberis Recens;

(12) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(13) Herba Taxilli: wash, runs through, and cutting is dried;

(14) Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;

(15) Semen sojae atricolor: pick clean impurity, dry;

(16) Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and pick clean Rhizoma Cibotii, fry to heaving and showing buff with high heat, take out, screen out sand, after wind dries in the air, hits or scraping Huang floss hair;

(17) Rhizoma Curcumae: get crude drug, removing impurity, size stepping, cleans, and slightly soaks, and takes out, runs through, shave, dry, and sieve removes chip;

(18) Fructus Leonuri: extract Herb during fruit maturation, dries, and lays fruit, picks debranching leaf, well sifted impurity;

(19) Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;

(20) Fructus Jujubae: pick clean impurity, dry;

(21) Folium Photiniae (Folium Photiniae serrulatae): clean, micro-profit, shredding is dried;

(22) Pericarpium Granati: pick decontamination, removes residual interior flesh and son, and clean, stripping and slicing, dries;

(23) Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

(24) Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

(25) Fructus Trichosanthis: get crude drug, removing impurity and fruit stem, clean, and flattens, shredding or fritter, dry;

(26) Flos Campsis: 7-9 gathers between the month, selects fine day and takes just open flower, dry;

(27) Cornu Cervi Degelatinatum: pick decontamination, hacks into fritter;

(28) Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

(29) Fluoritum: clean earth, be pounded fritter;

(30) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;

(31) Bombyx mori L.: removing impurity, sieve dedust bits;

(2) prepare

(1) Herba Verbenae of described weight, Arillus Longan, Cortex Moutan, Semen Persicae, Fructus Aurantii Immaturus, Herba Epimedii, Radix Codonopsis, Fructus Rubi, Herba Lycopi, Flos Rosae Chinensis, Cortex Magnoliae Officinalis, Eupolyphaga Seu Steleophaga, Herba Taxilli, Radix Asparagi, Semen sojae atricolor, Rhizoma Cibotii, Rhizoma Curcumae, Fructus Leonuri, Rhizoma Cyperi, Fructus Jujubae, Folium Photiniae (Folium Photiniae serrulatae), Pericarpium Granati, Rhizoma Curculiginis, Herba Leonuri, Fructus Trichosanthis, Flos Campsis, Cornu Cervi Degelatinatum, Radix Clematidis, Fluoritum, Fructus Schisandrae Chinensis, Bombyx mori L. medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor;

(2) add water the medicinal residues of filtration 6 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

(3) merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into by medicinal liquid 4 doses to take.